@prefix rdf: . @prefix : . @prefix dc: . @prefix hp: . @prefix hp1: . @prefix obo: . @prefix owl: . @prefix xml: . @prefix xsd: . @prefix rdfs: . @prefix skos: . @prefix oboInOwl: . oboInOwl:hasDbXref "ERO:0001964" . obo:APOLLO_SV_00000241 obo:IAO_0000115 "An information content entity specifying the upper and lower limit of a range of ages of continuants." ; obo:SCDO_0000340 obo:APOLLO_SV_00000241 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000403" ; oboInOwl:hasDbXref "APOLLO_SV:00000241" ; a owl:Class ; rdfs:label "Age Range Category" ; rdfs:subClassOf obo:SCDO_0300005 . obo:ARO_0000006 obo:IAO_0000115 "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ARO_0000006" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003119" ; oboInOwl:hasDbXref "ARO:0000006" ; oboInOwl:hasExactSynonym "Abomacetin", "Emgel", "Eritromicina", "Erymax", "Erythrocin", "Erythromycin A", "Erythromycine", "Erythromycinum", "N-methylerythromycin A" ; a owl:Class ; rdfs:label "Erythromycin" ; rdfs:subClassOf obo:NCIT_C258, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:ARO_0000054 obo:IAO_0000115 "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." ; obo:SCDO_0000340 obo:ARO_0000054 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000880" ; oboInOwl:hasDbXref "ARO:0000054" ; oboInOwl:hasExactSynonym "PCN", "Penicillins" ; a owl:Class ; rdfs:label "Penicillin" ; rdfs:subClassOf obo:NCIT_C258, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ] . obo:ARO_0000064 obo:IAO_0000115 "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ARO_0000064" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002381" ; oboInOwl:hasDbXref "ARO:0000064" ; oboInOwl:hasExactSynonym "AMX", "Amolin", "Amopenixin", "Amoxicilina", "Amoxicilline", "Amoxicillinum", "Clamoxyl", "D-Amoxicillin", "Moxal" ; a owl:Class ; rdfs:label "Amoxycillin" ; rdfs:subClassOf obo:ARO_0000054, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:CHEBI_23888 obo:IAO_0000115 "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." ; obo:SCDO_0000303 """Add sub-class \"Iron Chelator\" with sub-classes \"Deferoxamine\" and \"Deferiprone\" (see wikipedia page for \"Beta Thalassemia\"...mentions how they're used to treat beta thalassemia major). Also add \"Deferoxamine\" and \"Deferiprone\" below \"Iron Chelation Therapy\".""" ; obo:SCDO_0000340 obo:CHEBI_23888 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000200" ; oboInOwl:hasDbXref "CHEBI:23888" ; a owl:Class ; rdfs:label "Drug" ; rdfs:subClassOf obo:SCDO_0001152 . obo:CHEBI_35475 obo:IAO_0000115 "An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_35475" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005809" ; oboInOwl:hasDbXref "CHEBI:35475" ; oboInOwl:hasExactSynonym "Non-Steroidal Anti-Inflammatory Agent" ; a owl:Class ; rdfs:label "Non-Steroidal Anti-Inflammatory Drug" ; rdfs:subClassOf obo:SCDO_0000057, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:CHEBI_35482 obo:IAO_0000115 "A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_35482" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000836" ; oboInOwl:hasDbXref "CHEBI:35482" ; oboInOwl:hasExactSynonym "Opioid Analgesic" ; a owl:Class ; rdfs:label "Opioid" ; rdfs:subClassOf obo:SCDO_0000050, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:CHEBI_35493 obo:IAO_0000115 "A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_35493" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005335" ; oboInOwl:hasDbXref "CHEBI:35493" ; oboInOwl:hasExactSynonym "Anti-Pyretic" ; a owl:Class ; rdfs:label "Antipyretic" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:CHEBI_42797 obo:IAO_0000115 "A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_42797" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007493" ; oboInOwl:hasDbXref "CHEBI:42797" ; oboInOwl:hasExactSynonym "1-(Aminomethyl)cyclohexaneacetic acid", "Neurontin" ; a owl:Class ; rdfs:label "Gabapentin" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:CHEBI_50858 obo:IAO_0000115 "A natural or synthetic analogue of the hormones secreted by the adrenal gland." ; obo:SCDO_0000340 obo:CHEBI_50858 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003901" ; oboInOwl:hasDbXref "CHEBI:50858" ; oboInOwl:hasExactSynonym "Corticoides", "Corticosteroides", "Corticosteroids" ; a owl:Class ; rdfs:label "Corticosteroid" ; rdfs:subClassOf obo:SCDO_0000057 . obo:CHEBI_5790 obo:IAO_0000115 "An opioid analgesic derived from morphine and used mainly as an analgesic. It has a shorter duration of action and is more potent than morphine." ; obo:SCDO_0000340 "http://www.drugbank.ca/drugs/DB00327" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000577" ; oboInOwl:hasDbXref "CHEBI:5790" ; oboInOwl:hasExactSynonym "3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one" ; a owl:Class ; rdfs:label "Hydromorphone" ; rdfs:subClassOf obo:CHEBI_35482 . obo:CHEBI_60809 obo:IAO_0000115 "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_60809" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000025" ; oboInOwl:hasDbXref "CHEBI:60809" ; oboInOwl:hasExactSynonym "Adjuvant Medicine" ; a owl:Class ; rdfs:label "Adjuvant" ; rdfs:subClassOf obo:SCDO_0001152, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C39547 ] . obo:CHEBI_6807 obo:IAO_0000115 "A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence." ; obo:SCDO_0000340 "http://www.drugbank.ca/drugs/DB00333" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000752" ; oboInOwl:hasDbXref "CHEBI:6807" ; oboInOwl:hasExactSynonym "6-(dimethylamino)-4,4-diphenylheptan-3-one", "Physeptone" ; a owl:Class ; rdfs:label "Methadone" ; rdfs:subClassOf obo:CHEBI_35482, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:CHEBI_6909 obo:IAO_0000115 "A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_6909" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002912" ; oboInOwl:hasDbXref "CHEBI:6909" ; oboInOwl:hasExactSynonym "Satric", "Trichazol" ; a owl:Class ; rdfs:label "Metronidazole" ; rdfs:subClassOf obo:NCIT_C258, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:CHEBI_7852 obo:IAO_0000115 "A semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine." ; obo:SCDO_0000340 "http://www.drugbank.ca/drugs/DB00497" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000847" ; oboInOwl:hasDbXref "CHEBI:7852" ; oboInOwl:hasExactSynonym "14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one", "Dihydrone" ; a owl:Class ; rdfs:comment "An extended-release (ER) form of oxycodone (Xtampza ER) was approved for the management of daily, around-the-clock pain management in April, 2016." ; rdfs:label "Oxycodone" ; rdfs:subClassOf obo:CHEBI_35482, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:CHMO_0001009 obo:IAO_0000115 "Column chromatography where the mobile phase is a liquid, the stationary phase consists of very small particles and the inlet pressure is relatively high." ; obo:SCDO_0000303 "Perhaps change label to \"Hemoglobin by High Performance Liquid Chromatography\"? See dc:source provided." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHMO_0001009" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000563" ; dc:source ; oboInOwl:hasDbXref "CHMO:0001009" ; oboInOwl:hasExactSynonym "HPLC", "High Performance Liquid Chromatography", "High Pressure Liquid Chromatography", "High-Pressure Liquid Chromatography" ; a owl:Class ; rdfs:label "High-Performance Liquid Chromatography" ; rdfs:subClassOf obo:SCDO_0000216, obo:SCDO_1000577 . obo:CHMO_0002580 obo:IAO_0000115 "A test which produces colour change in the sample." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHMO_0002580" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000264" ; oboInOwl:hasDbXref "CHMO:0002580" ; a owl:Class ; rdfs:label "Colorimetric Test" ; rdfs:subClassOf obo:SCDO_0000120 . obo:CMO_0000001 obo:IAO_0000115 "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000001" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000186" ; oboInOwl:hasDbXref "CMO:0000001" ; a owl:Class ; rdfs:label "Cardiovascular Measurement" ; rdfs:subClassOf obo:SCDO_0000728 . obo:CMO_0000003 obo:IAO_0000115 "Measurement of the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood." ; obo:SCDO_0000303 "There are many more specific sub-classes in the CMO. Are there any we want to include here?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000003" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000144" ; oboInOwl:hasDbXref "CMO:0000003" ; a owl:Class ; rdfs:label "Blood Pressure Measurement" ; rdfs:subClassOf obo:CMO_0000001, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0001097 ] . obo:CMO_0000011 obo:IAO_0000115 "Morphological measurement involving the entire body of an organism." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000011" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001245" ; oboInOwl:hasDbXref "CMO:0000011" ; a owl:Class ; rdfs:label "Whole Body Morphological Measurement" ; rdfs:subClassOf obo:CMO_0000021 . obo:CMO_0000015 obo:IAO_0000115 "The level of heat in an organism." ; obo:SCDO_0000340 obo:CMO_0000015 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000151" ; oboInOwl:hasDbXref "CMO:0000015" ; a owl:Class ; rdfs:label "Body Temperature" ; rdfs:subClassOf obo:SCDO_0000728, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:OBI_0002140 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0005533 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0005534 ] . obo:CMO_0000021 obo:IAO_0000115 "Measurement of the structure or forms of the entire body or parts of the body of an organism." ; obo:SCDO_0000303 "Include the term \"Body Composition\" from PhenX? -- -- Any other relevant terms missing as sub-classes here?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000021" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000150" ; oboInOwl:hasDbXref "CMO:0000021" ; oboInOwl:hasExactSynonym "Anthropometric Measurement", "Anthropometrics", "Morphometry" ; a owl:Class ; rdfs:label "Body Morphological Measurement" ; rdfs:subClassOf obo:SCDO_0000728 . obo:CMO_0000023 obo:IAO_0000115 "A quantification of a parameter of the chemical composition of blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000023" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000136" ; oboInOwl:hasDbXref "CMO:0000023" ; a owl:Class ; rdfs:label "Blood Chemistry Measurement" ; rdfs:subClassOf obo:CMO_0000035 . obo:CMO_0000025 obo:IAO_0000115 "The number of red blood cells in a specified volume of blood most commonly 1 cubic millimeter (i.e. 1 microliter) of peripheral venous blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000025" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000973" ; oboInOwl:hasDbXref "CMO:0000025" ; oboInOwl:hasExactSynonym "Erythrocyte Count", "Erythrocyte Number", "Erythrocyte Numbers", "Red Blood Count" ; a owl:Class ; rdfs:label "Red Blood Cell Count" ; rdfs:subClassOf obo:CMO_0001356, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0000504 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0020059 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0020060 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000822 ] . obo:CMO_0000027 obo:IAO_0000115 "The number of white blood cells in a specified volume of blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000027" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001243" ; oboInOwl:hasDbXref "CMO:0000027" ; oboInOwl:hasExactSynonym "Leukocyte Count", "White Corpuscle Count" ; a owl:Class ; rdfs:label "White Blood Cell Count" ; rdfs:subClassOf obo:CMO_0002341, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0000504 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0001882 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0001974 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000823 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:CMO_0000029 obo:IAO_0000115 "The number of platelets (thrombocytes) in a specified volume of blood, usually expressed as platelets per cubic millimeter of whole blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000029" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000906" ; oboInOwl:hasDbXref "CMO:0000029" ; oboInOwl:hasExactSynonym "Blood Platelet Number", "Blood Platelet count", "Platelet Number" ; a owl:Class ; rdfs:label "Platelet Count" ; rdfs:subClassOf obo:CMO_0000921, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0000504 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0001873 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0001894 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000824 ] . obo:CMO_0000030 obo:IAO_0000115 "The number of granulocytes categorized as neutrophils in a specified volume of blood. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes." ; obo:SCDO_0000340 obo:CMO_0000030 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000442" ; oboInOwl:hasDbXref "CMO:0000030" ; oboInOwl:hasExactSynonym "Neutrophil Granulocyte Count" ; a owl:Class ; rdfs:label "Blood Neutrophil Count" ; rdfs:subClassOf obo:CMO_0000111 . obo:CMO_0000035 obo:IAO_0000115 "A measurement of the blood, it's contents, cells or other factors contained within the blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000035" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000143" ; oboInOwl:hasDbXref "CMO:0000035" ; a owl:Class ; rdfs:label "Blood Measurement" ; rdfs:subClassOf obo:SCDO_0000728 . obo:CMO_0000036 obo:IAO_0000115 "A value resulting from the quantification of a morphological or physiological parameter of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning." ; obo:SCDO_0000303 "Perhaps include missing sub-classes of \"Blood Cell Measurement\" from the Clinical Measurement Ontology?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000036" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000135" ; oboInOwl:hasDbXref "CMO:0000036" ; a owl:Class ; rdfs:label "Blood Cell Measurement" ; rdfs:subClassOf obo:CMO_0000035 . obo:CMO_0000037 obo:IAO_0000115 "Percentage of total blood volume that is made up of red blood cells." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000037" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000503" ; oboInOwl:hasDbXref "CMO:0000037" ; oboInOwl:hasExactSynonym "Hct", "Packed Cell Volume", "Packed Red Blood Cell Volume" ; a owl:Class ; rdfs:label "Hematocrit" ; rdfs:subClassOf obo:CMO_0001356, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:CMO_0000038 obo:IAO_0000115 "A measure of the average volume or size of a single red blood cell. It is derived by dividing the total volume of packed red blood cells by the total red blood cell count." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000038" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000723" ; oboInOwl:hasDbXref "CMO:0000038" ; oboInOwl:hasExactSynonym "MCV", "Mean Cell Volume" ; a owl:Class ; rdfs:label "Mean Corpuscular Volume" ; rdfs:subClassOf obo:CMO_0001356, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0005518 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0025066 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000825 ] . obo:CMO_0000057 obo:IAO_0000115 "The amount of creatinine, a catabolic product of creatine phosphate used in skeletal muscle contraction found in a specified volume of serum." ; obo:SCDO_0000303 "Link to \"Glomerular Filtration Rate\"... which object property? Create a new one and suggest to RO? \"used to calculate\"?" ; obo:SCDO_0000340 obo:CMO_0000057 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001042" ; oboInOwl:hasDbXref "CMO:0000057" ; oboInOwl:hasExactSynonym "Creatinine Level" ; a owl:Class ; rdfs:label "Serum Creatinine Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000570 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000296 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0012101 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000649 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000829 ] . obo:CMO_0000094 obo:IAO_0000115 "A measurement to assess the morphological or physiological state of the respiratory system or portion of the respiratory system." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000094" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000995" ; oboInOwl:hasDbXref "CMO:0000094" ; a owl:Class ; rdfs:label "Respiratory System Measurement" ; rdfs:subClassOf obo:SCDO_0000728 . obo:CMO_0000111 obo:IAO_0000115 "The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter." ; obo:SCDO_0000340 obo:CMO_0000111 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000441" ; oboInOwl:hasDbXref "CMO:0000111" ; a owl:Class ; rdfs:label "Blood Granulocyte Count" ; rdfs:subClassOf obo:CMO_0000366 . obo:CMO_0000123 obo:IAO_0000115 "The amount of bilirubin found in a specific volume of blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000123" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000134" ; oboInOwl:hasDbXref "CMO:0000123" ; oboInOwl:hasExactSynonym "Bilirubin Level" ; a owl:Class ; rdfs:label "Blood Bilirubin Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000119 ] . obo:CMO_0000195 obo:IAO_0000115 "Any measurement of the movement of blood through the heart and blood vessels." ; obo:SCDO_0000303 """Add any more from below \"circulation measurement\" in the CMO? Suggest to CMO \"Blood Flow Measurement\" be an exact synonym of \"Circulation Measurement\", as we have made it here. Suggest to CRISP that their \"blood flow measurement\" instead be \"Blood Flow Test\".""" ; obo:SCDO_0000340 obo:CMO_0000195 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000142" ; oboInOwl:hasDbXref "CMO:0000195" ; oboInOwl:hasExactSynonym "Circulation Measurement" ; a owl:Class ; rdfs:label "Blood Flow Measurement" ; rdfs:subClassOf obo:CMO_0000001 . obo:CMO_0000204 obo:IAO_0000115 "Measurement to assess the sequential process through which multiple factors of the blood interact to form an insoluble fibrin clot." ; obo:SCDO_0000303 """Add other sub-classes of \"Blood Coagulation Measurement\" from the CMO? blood fibrinogen level? thrombin time? activated clotting time (ACT)? platelet aggregation measurement? bleeding time (BT)?""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000204" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000137" ; oboInOwl:hasDbXref "CMO:0000204" ; a owl:Class ; rdfs:label "Blood Coagulation Measurement" ; rdfs:subClassOf obo:CMO_0000035 . obo:CMO_0000210 obo:IAO_0000115 "The time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent. It is used to evaluate the intrinsic clotting system." ; obo:SCDO_0000340 obo:CMO_0000210 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000014" ; oboInOwl:hasDbXref "CMO:0000210" ; oboInOwl:hasExactSynonym "APTT; Quick" ; a owl:Class ; rdfs:label "Activated Partial Thromboplastin Time" ; rdfs:subClassOf obo:CMO_0000204 . obo:CMO_0000211 obo:IAO_0000115 "Measurement of the clotting ability of fibrinogen, prothrombin, proaccelerin, proconvertin and Stuart factor, usually given in seconds to formation of clot after the addition of a tissue factor or thromboplastin." ; obo:SCDO_0000340 obo:CMO_0000211 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000933" ; oboInOwl:hasDbXref "CMO:0000211" ; oboInOwl:hasExactSynonym "PTT" ; a owl:Class ; rdfs:label "Prothrombin Time" ; rdfs:subClassOf obo:CMO_0000204 . obo:CMO_0000225 obo:IAO_0000115 "Any measurement of a gas or gases dissolved in arterial blood, that is, blood which has absorbed oxygen in the lungs, including oxygen, nitrogen carbon dioxide and/or hydrogen." ; obo:SCDO_0000340 obo:CMO_0000225 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000718" ; oboInOwl:hasDbXref "CMO:0000225" ; a owl:Class ; rdfs:label "Arterial Blood Gas Measurement" ; rdfs:subClassOf obo:CMO_0001321 . obo:CMO_0000256 obo:IAO_0000115 "Any measurement of urine, the fluid waste product excreted by the kidneys, or its components." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000256" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001214" ; oboInOwl:hasDbXref "CMO:0000256" ; a owl:Class ; rdfs:label "Urine Measurement" ; rdfs:subClassOf obo:SCDO_0000728 . obo:CMO_0000283 obo:IAO_0000115 "The force per unit area attributable to the carbon dioxide, a colorless, odorless, incombustible gas formed during respiration and composed of one atom of carbon and two atoms of oxygen, dissolved in a specified volume of blood, defined as the force per unit area exerted by carbon dioxide in a mixture of gases in equilibrium with such a sample of blood at the same temperature." ; obo:SCDO_0000340 obo:CMO_0000283 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000719" ; oboInOwl:hasDbXref "CMO:0000283" ; oboInOwl:hasExactSynonym "PaCO2", "Partial Pressure of Blood Carbon Dioxide", "Partial Pressure of Blood Carbon Dioxide (Pco2)", "Partial Pressure of Carbon Dioxide (PaCO2)", "Pco2" ; a owl:Class ; rdfs:label "Partial Pressure of Carbon Dioxide" ; rdfs:subClassOf obo:CMO_0000225, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000839 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000840 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000841 ] . obo:CMO_0000290 obo:IAO_0000115 "The average amount of hemoglobin per red blood cell calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000290" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000722" ; oboInOwl:hasDbXref "CMO:0000290" ; oboInOwl:hasExactSynonym "MCH", "Mean Cell Hemoglobin", "Mean Cell Hemoglobin Level", "Mean Corpuscular Haemoglobin", "Mean Corpuscular Haemoglobin Level", "Mean Corpuscular Hemoglobin" ; a owl:Class ; rdfs:label "Mean Corpuscular Hemoglobin Level" ; rdfs:subClassOf obo:CMO_0001356, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0005561 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0005562 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000826 ] . obo:CMO_0000291 obo:IAO_0000115 "The amount of hemoglobin in a given volume of packed red blood cells and is often calculated by dividing the hemoglobin concentration by the hematocrit." ; obo:SCDO_0000303 "Add the sub-class \"mean corpuscular sickle hemoglobin concentration (MCSHC)\"? (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC290884/pdf/jcinvest00309-0076.pdf)" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000291" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000721" ; oboInOwl:hasDbXref "CMO:0000291" ; oboInOwl:hasExactSynonym "MCHC", "Mean Cell Hemoglobin Concentration", "Mean Corpuscular Haemoglobin Concentration" ; a owl:Class ; rdfs:label "Mean Corpuscular Hemoglobin Concentration" ; rdfs:subClassOf obo:CMO_0001356, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0025547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0025548 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000827 ] . obo:CMO_0000364 obo:IAO_0000115 "The calculation of the cellular elements of the blood, usually including cell counts for white and red blood cells and platelets." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000364" ; obo:SCDO_0000479 , "PhenX protocol: Complete Blood Count #220501" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000270" ; oboInOwl:hasDbXref "CMO:0000364" ; oboInOwl:hasExactSynonym "Blood Cell Count", "Blood Cell Number", "CBC", "FBC", "Full Blood Count" ; a owl:Class ; rdfs:label "Complete Blood Count" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000740 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_1000342 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:CMO_0000365 obo:IAO_0000115 "The total number of leukocytes in 1 cubic millimeter of peripheral venous blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000365" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001163" ; oboInOwl:hasDbXref "CMO:0000365" ; a owl:Class ; rdfs:label "Total White Blood Cell Count" ; rdfs:subClassOf obo:CMO_0000027, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:CMO_0000366 obo:IAO_0000115 "The number of each type of leukocyte present in a specific volume of blood, usually 1 cubic millimeter." ; obo:SCDO_0000303 "Perhaps add sub-classes from \"Clinical Measurement Ontology\"?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000366" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000140" ; oboInOwl:hasDbXref "CMO:0000366" ; oboInOwl:hasExactSynonym "Blood Differential Leukocyte Count", "Blood Differential WBC Count", "WBC Differential Count" ; a owl:Class ; rdfs:label "Blood Differential White Blood Cell Count" ; rdfs:subClassOf obo:CMO_0000027 . obo:CMO_0000376 obo:IAO_0000115 "The complete or entire amount of bilirubin in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Bilirubin is the bile pigment produced by breakdown of heme and reduction of biliverdin." ; obo:SCDO_0000340 obo:CMO_0000376 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000500" ; oboInOwl:hasDbXref "CMO:0000376" ; a owl:Class ; rdfs:label "Total Serum Bilirubin Level" ; rdfs:subClassOf obo:CMO_0000123, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000119 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0003573 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000835 ] . obo:CMO_0000506 obo:IAO_0000115 "The amount of hemoglobin, the red oxygen-carrying pigment of erythrocytes, in a specified volume of blood, as calculated from the optical density of a solution of lysed red cells in which hemoglobin has been converted to cyanomethemoglobin and measured with a spectrophotometer." ; obo:SCDO_0000340 obo:CMO_0000506 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000523" ; oboInOwl:hasDbXref "CMO:0000506" ; oboInOwl:hasExactSynonym "Hbtotal", "Hemoglobin Level", "Total Hemoglobin", "Total Hemoglobin (Hbtotal)", "ctHB" ; a owl:Class ; rdfs:label "Hemoglobin Concentration" ; rdfs:subClassOf obo:CMO_0000508, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0020062 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0020063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000783 ] . obo:CMO_0000507 obo:IAO_0000115 "The optical density as calculated from the intensity of light at a specified wavelength as it passes through a solution of lysed red blood cells." ; obo:SCDO_0000340 obo:CMO_0000507 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000249" ; oboInOwl:hasDbXref "CMO:0000507" ; a owl:Class ; rdfs:label "Hemoglobin Absorbance" ; rdfs:subClassOf obo:CMO_0000508 . obo:CMO_0000508 obo:IAO_0000115 "A measure of the oxygen carrying pigment of erythrocytes." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000508" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000543" ; oboInOwl:hasDbXref "CMO:0000508" ; a owl:Class ; rdfs:label "Hemoglobin Measurement" ; rdfs:subClassOf obo:CMO_0000036 . obo:CMO_0000665 obo:IAO_0000115 "Pressure exerted by the heart muscle in its maximally contracted state." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000665" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000499" ; oboInOwl:hasDbXref "CMO:0000665" ; a owl:Class ; rdfs:label "Heart Contraction Pressure" ; rdfs:subClassOf obo:SCDO_1000317 . obo:CMO_0000921 obo:IAO_0000115 "Any measurement of platelets, the disk-shaped structures found in the blood of mammals which play a vital role in blood coagulation. Platelets lack nuclei and DNA but contain active enzymes and mitochondria." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000921" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000907" ; oboInOwl:hasDbXref "CMO:0000921" ; a owl:Class ; rdfs:label "Platelet Measurement" ; rdfs:subClassOf obo:CMO_0000036 . obo:CMO_0001321 obo:IAO_0000115 "Any measurement of a gas or gases dissolved in the blood, including oxygen, nitrogen carbon dioxide and/or hydrogen." ; obo:SCDO_0000340 obo:CMO_0001321 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000312" ; oboInOwl:hasDbXref "CMO:0001321" ; a owl:Class ; rdfs:label "Blood Gas Measurement" ; rdfs:subClassOf obo:CMO_0000035 . obo:CMO_0001324 obo:IAO_0000115 "The amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity." ; obo:SCDO_0000340 obo:CMO_0001324 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000848" ; oboInOwl:hasDbXref "CMO:0001324" ; oboInOwl:hasExactSynonym "HbO2", "Oxyhemoglobin Saturation", "Oxyhemoglobin Saturation (HbO2)", "SO2", "SaO2", "Sats" ; a owl:Class ; rdfs:label "Oxygen Saturation" ; rdfs:subClassOf obo:CMO_0001321 . obo:CMO_0001356 obo:IAO_0000115 "Any measurement of a single red blood cell, one of the hemoglobin-containing blood cells that transport oxygen and carbon dioxide to and from the tissues, or of all of the red blood cells in a sample of blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0001356" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000974" ; oboInOwl:hasDbXref "CMO:0001356" ; oboInOwl:hasExactSynonym "Erythrocyte Measurement" ; a owl:Class ; rdfs:label "Red Blood Cell Measurement" ; rdfs:subClassOf obo:CMO_0000036 . obo:CMO_0002079 obo:IAO_0000115 "The heaviness or degree to which the entire body of an organism at the point of or shortly after birth is drawn to the earth by gravity." ; obo:SCDO_0000340 obo:CMO_0002079 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000311" ; oboInOwl:hasDbXref "CMO:0002079" ; oboInOwl:hasExactSynonym "Body Weight of Neonate", "Neonatal Body Weight" ; a owl:Class ; rdfs:label "Birth Weight" ; rdfs:subClassOf obo:SCDO_0000152 . obo:CMO_0002341 obo:IAO_0000115 "Any value resulting from the quantification of a morphological or physiological parameter of leukocytes, largely colorless blood corpuscles capable of ameboid movement, whose chief function is to protect the body against microorganisms and other disease-causing entities." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0002341" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001244" ; oboInOwl:hasDbXref "CMO:0002341" ; a owl:Class ; rdfs:label "White Blood Cell Measurement" ; rdfs:subClassOf obo:CMO_0000036 . obo:CMO_0002520 obo:IAO_0000115 "Measurement of the amount of haptoglobin in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Haptoglobin is a serum alpha2 globulin glycoprotein, produced by the liver, that functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin." ; obo:SCDO_0000340 obo:CMO_0002520 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000467" ; oboInOwl:hasDbXref "CMO:0002520" ; oboInOwl:hasExactSynonym "Haptoglobin Level", "Haptoglobin Levels" ; a owl:Class ; rdfs:label "Serum Haptoglobin Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000466 ] . obo:CMO_0002876 obo:IAO_0000115 "The amount of N-terminal (NT)-pro hormone BNP (Nppb) in a specified volume of blood." ; obo:SCDO_0000303 """Value given as 1 Decimal Place Nanogram per Liter (according to PhenX https://www.phenxtoolkit.org/protocols/view/810501) associated with acute congestive heart failure (http://www.ebi.ac.uk/efo/EFO_0004745)""" ; obo:SCDO_0000340 obo:CMO_0002876 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000786" ; oboInOwl:hasDbXref "CMO:0002876" ; oboInOwl:hasExactSynonym "BNPT Level", "Blood NH2-Terminal pro-B-Type Natriuretic Peptide Level", "N-Terminal Prohormone of Brain Natriuretic Peptide Level", "NT-proBNP Level", "NT-proBNP Measurement" ; a owl:Class ; rdfs:label "N-Terminal Pro-Brain Natriuretic Peptide Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000787 ] . obo:DOID_0050731 obo:IAO_0000115 "A vitamin metabolic disorder that results from low blood levels of vitamin B12." ; obo:SCDO_0000340 obo:DOID_0050731 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005733" ; oboInOwl:hasDbXref "DOID:0050731" ; oboInOwl:hasExactSynonym "Cobalamin Deficiency", "Hypocobalaminemia" ; a owl:Class ; rdfs:label "Vitamin B12 Deficiency" ; rdfs:subClassOf obo:SCDO_1000261 . obo:DOID_0060181 obo:IAO_0000115 "A colitis caused by inadequate blood supply to the colon." ; obo:SCDO_0000303 "Is diagnosed by: abdominal computed tomography scan" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/DOID_0060181" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002870" ; oboInOwl:hasDbXref "DOID:0060181" ; a owl:Class ; rdfs:label "Ischemic Cholitis" ; rdfs:subClassOf obo:HP_0025031, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ] . obo:DOID_0111033 obo:IAO_0000115 "A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums." ; obo:SCDO_0000340 obo:DOID_0111033 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000282" ; oboInOwl:hasDbXref "DOID:0111033" ; oboInOwl:hasExactSynonym "Bantu Siderosis", "Iron Overload in Africa" ; a owl:Class ; rdfs:label "African Iron Overload" ; rdfs:subClassOf obo:SCDO_1000281 . obo:DOID_1188 obo:IAO_0000115 "A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve." ; obo:SCDO_0000340 obo:DOID_1188 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000769" ; oboInOwl:hasDbXref "DOID:1188" ; oboInOwl:hasExactSynonym "Single Damaged Nerve" ; a owl:Class ; rdfs:label "Mononeuropathy" ; rdfs:subClassOf obo:HP_0012639, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000963 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000822 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:DOID_1584 obo:IAO_0000115 "A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion." ; obo:SCDO_0000303 """This definition was given by the WG: 'Acute onset of respiratory symptoms and/or signs and an X-ray consistent with alveolar consolidation but not atelectasis, involving at least one complete lung segment.\" With this definition source:The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. O. Castro, D. J. Brambilla, B. Thorington, C. A. Reindorf, R. B. Scott, P. Gillette, J. C. Vera, P. S. Levy Blood. 1994 Jul 15; 84(2): 643–649. However, the definition did not seem to come from this source, so the DO term was used instead.""" ; obo:SCDO_0000340 obo:DOID_1584 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000015" ; oboInOwl:hasDbXref "DOID:1584" ; oboInOwl:hasExactSynonym "Acute Chest Syndrome in Sickle Cell Disease" ; a owl:Class ; rdfs:comment "From the DO: The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph." ; rdfs:label "Acute Chest Syndrome" ; rdfs:subClassOf obo:HP_0002086, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C15238 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000576 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:DOID_1826 obo:IAO_0000115 "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/DOID_1826" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008484" ; oboInOwl:hasDbXref "DOID:1826" ; a owl:Class ; rdfs:label "Epilepsy" ; rdfs:subClassOf obo:HP_0000708, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:DOID_2326 obo:IAO_0000115 "A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/DOID_2326" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007198" ; oboInOwl:hasDbXref "DOID:2326" ; a owl:Class ; rdfs:label "Gastroenteritis" ; rdfs:subClassOf obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:DOID_4 obo:IAO_0000115 "A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/DOID_4" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001365" ; oboInOwl:hasDbXref "DOID:4" ; a owl:Class ; rdfs:label "Disease" ; rdfs:subClassOf obo:SCDO_0001000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C17047 ] . obo:DOID_813 obo:IAO_0000115 "An arthritis that involves infection by a pathogen located in a joint." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/DOID_813" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002067" ; oboInOwl:hasDbXref "DOID:813" ; oboInOwl:hasExactSynonym "Infected Joint", "Infectious Arthritis" ; a owl:Class ; rdfs:label "Septic Arthritis" ; rdfs:subClassOf obo:HP_0000924, obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:DOID_9220 obo:IAO_0000115 "A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/DOID_9220" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000200" ; oboInOwl:hasDbXref "DOID:9220" ; oboInOwl:hasExactSynonym "Primary Central Sleep Apnea" ; a owl:Class ; rdfs:label "Central Sleep Apnea" ; rdfs:subClassOf obo:HP_0000708 . obo:DRON_00017565 obo:IAO_0000115 "A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion." ; obo:SCDO_0000340 "http://www.drugbank.ca/drugs/DB06694" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001254" ; oboInOwl:hasDbXref "DRON:00017565" ; oboInOwl:hasExactSynonym "Balminil", "Otrivin", "Xylomethazoline" ; a owl:Class ; rdfs:label "Xylometazoline" ; rdfs:subClassOf obo:SCDO_0000791 . obo:DUO_0000018 obo:IAO_0000115 "This requirement indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use." ; obo:SCDO_0000340 obo:DUO_0000018 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000413" ; oboInOwl:hasDbXref "DUO:0000018" ; a owl:Class ; rdfs:label "Not for Profit Use Only" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000019 obo:IAO_0000115 "This requirement indicates that requestor agrees to make results of studies using the data available to the larger scientific community." ; obo:SCDO_0000340 obo:DUO_0000019 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000416" ; oboInOwl:hasDbXref "DUO:0000019" ; a owl:Class ; rdfs:label "Publication Required" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000020 obo:IAO_0000115 "This could be coupled with a string describing the primary study investigator(s)." ; obo:SCDO_0000340 obo:DUO_0000020 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000409" ; oboInOwl:hasDbXref "DUO:0000020" ; a owl:Class ; rdfs:label "Collaboration Required" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000021 obo:IAO_0000115 "This requirement indicates that the requestor must provide documentation of local IRB/ERB approval." ; obo:SCDO_0000340 obo:DUO_0000021 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000410" ; oboInOwl:hasDbXref "DUO:0000021" ; a owl:Class ; rdfs:label "Ethics Approval Required" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000022 obo:IAO_0000115 "This should be coupled with an ontology term describing the geographical location the restriction applies to." ; obo:SCDO_0000340 obo:DUO_0000022 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000411" ; oboInOwl:hasDbXref "DUO:0000022" ; a owl:Class ; rdfs:label "Geographical Restriction" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000024 obo:IAO_0000115 "This should be coupled with a date specified as ISO8601" ; obo:SCDO_0000340 obo:DUO_0000024 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000415" ; oboInOwl:hasDbXref "DUO:0000024" ; a owl:Class ; rdfs:label "Publication Moratorium" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000025 obo:IAO_0000115 "This should be coupled with an integer value indicating the number of months." ; obo:SCDO_0000340 obo:DUO_0000025 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000418" ; oboInOwl:hasDbXref "DUO:0000025" ; a owl:Class ; rdfs:label "Time Limit on Use" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000026 obo:IAO_0000115 "This requirement indicates that use is limited to use by approved users." ; obo:SCDO_0000340 obo:DUO_0000026 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000419" ; oboInOwl:hasDbXref "DUO:0000026" ; a owl:Class ; rdfs:label "User Specific Restriction" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000027 obo:IAO_0000115 "This requirement indicates that use is limited to use within an approved project." ; obo:SCDO_0000340 obo:DUO_0000027 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000414" ; oboInOwl:hasDbXref "DUO:0000027" ; a owl:Class ; rdfs:label "Project Specific Restriction" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000028 obo:IAO_0000115 "This requirement indicates that use is limited to use within an approved institution." ; obo:SCDO_0000340 obo:DUO_0000028 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000412" ; oboInOwl:hasDbXref "DUO:0000028" ; a owl:Class ; rdfs:label "Institution Specific Restriction" ; rdfs:subClassOf obo:SCDO_1000408 . obo:DUO_0000029 obo:IAO_0000115 "This requirement indicates that the requestor must return derived/enriched data to the database/resource." ; obo:SCDO_0000340 obo:DUO_0000029 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000417" ; oboInOwl:hasDbXref "DUO:0000029" ; a owl:Class ; rdfs:label "Return to Database or Resource" ; rdfs:subClassOf obo:SCDO_1000408 . obo:ENVO_02500036 obo:IAO_0000115 "An environmental system process that results in the introduction of contaminants into an environment." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ENVO_02500036" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000912" ; oboInOwl:hasDbXref "ENVO:02500036" ; oboInOwl:hasExactSynonym "Environmental Pollution" ; a owl:Class ; rdfs:label "Pollution" ; rdfs:subClassOf obo:SCDO_0000897 . obo:EUPATH_0000034 obo:IAO_0000115 "A genotype information which is about the presence and degree of alpha-thalassemia, a form of thalassemia involving the number of functional HBA1 and HBA2 genes." ; obo:SCDO_0000340 obo:EUPATH_0000034 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000216" ; oboInOwl:hasDbXref "EUPATH:0000034" ; a owl:Class ; rdfs:label "Alpha Thalassemia Genotype" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C95504 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C95535 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000240 ] . obo:EUPATH_0000050 obo:IAO_0000115 "A clinical visit that is primarily for a regular examination." ; obo:SCDO_0000340 obo:EUPATH_0000050 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000848" ; oboInOwl:hasDbXref "EUPATH:0000050" ; a owl:Class ; rdfs:label "Routine Clinical Visit" ; rdfs:subClassOf obo:NCIT_C103165 . obo:EUPATH_0000215 obo:IAO_0000115 "An anemia with hemoglobin levels less than 5 gm/dL." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/EUPATH_0000215" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000055" ; oboInOwl:hasDbXref "EUPATH:0000215" ; a owl:Class ; rdfs:label "Severe Anemia" ; rdfs:subClassOf obo:HP_0001903, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C15238 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000771 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001329 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0008888 ] . obo:EUPATH_0000310 obo:IAO_0000115 "An information content entity that is about a clinical visit." ; obo:SCDO_0000340 obo:EUPATH_0000310 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000851" ; oboInOwl:hasDbXref "EUPATH:0000310" ; a owl:Class ; rdfs:label "Information on Observation Details" ; rdfs:subClassOf obo:SCDO_0006339 . obo:EUPATH_0021227 obo:IAO_0000115 "A scalar measurement datum of the concentration of urea in blood that is a specified output of a blood test." ; obo:SCDO_0000340 obo:EUPATH_0021227 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000603" ; oboInOwl:hasDbXref "EUPATH:0021227" ; oboInOwl:hasExactSynonym "Serum Urea Concentration" ; a owl:Class ; rdfs:label "Blood Urea Concentration" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000605 ] . obo:ExO_0000034 obo:IAO_0000115 "An individual attribute that is the usual or principal work or business of an individual." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ExO_0000034" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000821" ; oboInOwl:hasDbXref "ExO:0000034" ; oboInOwl:hasExactSynonym "Career", "Employment", "Job", "Vocation" ; a owl:Class ; rdfs:label "Occupation" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_0001090, obo:SCDO_1000157 . obo:ExO_0000048 obo:IAO_0000115 "Human-made surroundings that provide the setting for human activity, ranging in scale from personal shelter and buildings to neighborhoods and cite, and can often include their supporting infrastructure, such as water supply or energy networks." ; obo:SCDO_0000340 obo:ExO_0000048 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000167" ; oboInOwl:hasDbXref "ExO:0000048" ; a owl:Class ; rdfs:label "Built Environment" ; rdfs:subClassOf obo:SCDO_0000897 . obo:GAZ_00000448 obo:IAO_0000115 "A reference to a place on the Earth, by its name or by its geographical location." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/GAZ_00000448" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000451" ; oboInOwl:hasDbXref "GAZ:00000448" ; oboInOwl:hasExactSynonym "Geographic Region" ; a owl:Class ; rdfs:label "Geographic Location" ; rdfs:subClassOf obo:SCDO_0000897 . obo:GSSO_000109 obo:IAO_0000115 "Intersex is an umbrella term with a complex history. It is usually used to refer to persons with congenital conditions which involve differences in the many intertwined processes of sexual development." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000672" ; oboInOwl:hasDbXref "GSSO:000109" ; a owl:Class ; rdfs:label "Intersex" ; rdfs:subClassOf obo:NCIT_C91106 . obo:GSSO_003239 obo:IAO_0000115 "Principles which provide a framework within which ethical dilemmas and other problems may be analyzed." ; obo:SCDO_0000340 obo:GSSO_003239 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000427" ; oboInOwl:hasDbXref "GSSO:003239" ; a owl:Class ; rdfs:label "Ethical Principle" ; rdfs:subClassOf obo:SCDO_1000430 . obo:HP_0000005 obo:IAO_0000115 "The pattern in which a particular genetic trait or disorder is passed from one generation to the next." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000005" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001367" ; oboInOwl:hasDbXref "HP:0000005" ; oboInOwl:hasExactSynonym "Inheritance" ; a owl:Class ; rdfs:label "Mode of Inheritance" ; rdfs:subClassOf obo:SCDO_0001000 . obo:HP_0000006 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." ; obo:SCDO_0000340 obo:HP_0000006 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000140" ; oboInOwl:hasDbXref "HP:0000006" ; oboInOwl:hasExactSynonym "Autosomal Dominant Form", "Autosomal Dominant Inheritance", "Autosomal Dominant Predisposition" ; a owl:Class ; rdfs:label "Autosomal Dominant" ; rdfs:subClassOf obo:HP_0000005 . obo:HP_0000007 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygous (two copies of the same mutant allele) or compound heterozygous (whereby each copy of a gene has a distinct mutant allele)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000007" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001368" ; oboInOwl:hasDbXref "HP:0000007" ; oboInOwl:hasExactSynonym "Autosomal Recessive Form", "Autosomal Recessive Inheritance", "Autosomal Recessive Predisposition" ; a owl:Class ; rdfs:label "Autosomal Recessive" ; rdfs:subClassOf obo:HP_0000005 . obo:HP_0000027 obo:IAO_0000115 "Absence of any measurable level of sperm in a male's semen." ; obo:SCDO_0000340 obo:HP_0000027 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000092" ; oboInOwl:hasDbXref "HP:0000027" ; oboInOwl:hasExactSynonym "Absent Sperm in Semen" ; a owl:Class ; rdfs:label "Azoospermia" ; rdfs:subClassOf obo:HP_0000080 . obo:HP_0000044 obo:IAO_0000115 "Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH)." ; obo:SCDO_0000340 obo:HP_0000044 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002903" ; oboInOwl:hasDbXref "HP:0000044" ; oboInOwl:hasExactSynonym "Hypogonadotropic Hypogonadism", "Secondary Hypogonadism" ; a owl:Class ; rdfs:label "Hypogonadotropic Hypogonadism" ; rdfs:subClassOf obo:HP_0000080 . obo:HP_0000077 obo:IAO_0000115 "An abnormality of the kidney." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000077" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002133" ; oboInOwl:hasDbXref "HP:0000077" ; oboInOwl:hasExactSynonym "Abnormal Kidney", "Anomaly of the Kidney", "Renal Anomaly" ; a owl:Class ; rdfs:label "Abnormality of the Kidney" ; rdfs:subClassOf obo:HP_0000079 . obo:HP_0000078 obo:IAO_0000115 "An abnormality of the genital system." ; obo:SCDO_0000340 obo:HP_0000078 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000263" ; oboInOwl:hasDbXref "HP:0000078" ; oboInOwl:hasExactSynonym "Genital Abnormalities", "Genital Abnormality", "Genital Anomalies", "Genital Defects" ; a owl:Class ; rdfs:label "Abnormality of the Genital System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0000079 obo:IAO_0000115 "An abnormality of the urinary system." ; obo:SCDO_0000340 obo:HP_0000079 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001347" ; oboInOwl:hasDbXref "HP:0000079" ; oboInOwl:hasExactSynonym "Anomaly of the Urinary System", "Urinary Tract Abnormalities", "Urinary Tract Abnormality", "Urinary Tract Anomalies", "Urinary Tract Anomaly" ; a owl:Class ; rdfs:label "Abnormality of the Urinary System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0000080 obo:IAO_0000115 "An abnormal functionality of the genital system." ; obo:SCDO_0000340 obo:HP_0000080 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000270" ; oboInOwl:hasDbXref "HP:0000080" ; oboInOwl:hasExactSynonym "Abnormality of Genital Physiology" ; a owl:Class ; rdfs:label "Abnormality of Reproductive System Physiology" ; rdfs:subClassOf obo:HP_0000078 . obo:HP_0000084 obo:IAO_0000115 "Failure of the kidneys to adequately filter toxins and waste products from the blood; classified as acute (as in acute kidney injury) or chronic (as in chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MP_0003606" ; obo:SCDO_0000468 "Variable" ; obo:SCDO_0000472 "May be Acute (acute kidney injury) or chronic (chronic kidney disease)." ; obo:SCDO_0000661 "Has a variety of causes - dependent upon acuity - see definitions for acute kidney injury (acute renal failure) and chronic kidney disease." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000674" ; oboInOwl:hasDbXref "HP:0000084" ; oboInOwl:hasExactSynonym "Renal Failure", "Renal Insufficiency" ; a owl:Class ; rdfs:comment "Treatment is dependent upon etiology and acuity. If refractory to medical therapy, renal replacement or dialysis may be indicated." ; rdfs:label "Kidney Failure" ; rdfs:subClassOf obo:HP_0000077, obo:SCDO_1000383, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000004 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001210 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000096 obo:IAO_0000115 "Scarring and fibrosis within the glomerulus." ; obo:SCDO_0000340 obo:HP_0000096 ; obo:SCDO_0000661 "Any form of injury to the kidney can lead to glomerulosclerosis." ; obo:SCDO_0000662 "Histologically noted by scarring and fibrosis in the glomerulus." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000460" ; dc:source "NHLBI 2014 Guidelines" ; oboInOwl:hasDbXref "HP:0000096" ; oboInOwl:hasExactSynonym "Glomerular Sclerosis", "Renal Glomerular Fibrosis" ; a owl:Class ; rdfs:label "Glomerulosclerosis" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000097 obo:IAO_0000115 "Segmental accumulation of scar tissue in individual (but not all) glomeruli." ; obo:SCDO_0000340 obo:HP_0000097 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009968" ; oboInOwl:hasDbXref "HP:0000097" ; oboInOwl:hasExactSynonym "Focal Glomerulosclerosis", "Focal and Segmental Glomerular Sclerosis", "Focal and Segmental Glomerulosclerosis" ; a owl:Class ; rdfs:label "Focal Segmental Glomerulosclerosis" ; rdfs:subClassOf obo:HP_0000096 . obo:HP_0000099 obo:IAO_0000115 "Inflammation of the renal glomeruli." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0000099 ; obo:SCDO_0000468 "May occur at any age." ; obo:SCDO_0000661 "Variety of causes - in sickle cell disease, most common lesion is focal segmental glomerulosclerosis (FSGS) but also reported Membranoproliferative glomerulonephritis and other forms of glomerulonephritis." ; obo:SCDO_0000662 "Patients with hematuria may have dark-colored urine. Glomerulonephritis may lead to the proteinuria and \"foamy\" appearance of the urine. If the latter is substantial, patients may develop clinically evident edema." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000458" ; oboInOwl:hasDbXref "HP:0000099" ; oboInOwl:hasExactSynonym "GN", "Glomerular Nephritis" ; a owl:Class ; rdfs:label "Glomerulonephritis" ; rdfs:subClassOf obo:HP_0000123, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000219 ; owl:someValuesFrom obo:SCDO_0000508 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000219 ; owl:someValuesFrom obo:SCDO_0000932 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000112 obo:IAO_0000115 "A nonspecific term referring to disease or damage of the kidneys." ; obo:SCDO_0000340 obo:HP_0000112 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000795" ; oboInOwl:hasDbXref "HP:0000112" ; oboInOwl:hasExactSynonym "Kidney Damage", "Kidney Disease" ; a owl:Class ; rdfs:label "Nephropathy" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001205 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001206 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000055 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001213 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000118 obo:IAO_0000115 "A phenotype that shows detectable differences from normal." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/FYPO_0001985" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009818" ; oboInOwl:hasDbXref "HP:0000118" ; oboInOwl:hasExactSynonym "Phenotypic Abnormality" ; a owl:Class ; rdfs:label "Abnormal Phenotype" ; rdfs:subClassOf obo:OGMS_0000023 . obo:HP_0000123 obo:IAO_0000115 "The presence of inflammation affecting the kidney." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0000123 ; obo:SCDO_0000661 "May be caused by autoimmune disease, allergic responses, toxic injury, infectious causes." ; obo:SCDO_0000662 "May be associated with loss of kidney function, pyuria or hematuria, and proteinuria dependent upon cause." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000793" ; oboInOwl:hasDbXref "HP:0000123" ; oboInOwl:hasExactSynonym "Kidney Inflammation" ; a owl:Class ; rdfs:label "Nephritis" ; rdfs:subClassOf obo:HP_0000077, obo:HP_0002715, obo:SCDO_1000383, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0000132 obo:IAO_0000115 "Prolonged and/or excessive menses at regular intervals in excess of 80 ml or lasting longer than 7 days." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000132" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000745" ; oboInOwl:hasDbXref "HP:0000132" ; oboInOwl:hasExactSynonym "Abnormally Heavy Bleeding During Menstruation", "Hypermenorrhea" ; a owl:Class ; rdfs:label "Menorrhagia" ; rdfs:subClassOf obo:HP_0012243, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:HP_0000225 obo:IAO_0000115 "Hemorrhage affecting the gingiva." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000225" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000452" ; oboInOwl:hasDbXref "HP:0000225" ; oboInOwl:hasExactSynonym "Bleeding Gums", "Gingival Hemorrhage", "Gingivorrhagia" ; a owl:Class ; rdfs:label "Gingival Bleeding" ; rdfs:subClassOf obo:HP_0000271 . obo:HP_0000271 obo:IAO_0000115 "An abnormality of the face." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000271" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003024" ; oboInOwl:hasDbXref "HP:0000271" ; oboInOwl:hasExactSynonym "Facial Abnormality" ; a owl:Class ; rdfs:label "Abnormality of the Face" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0000388 obo:IAO_0000115 "Inflammation or infection of the middle ear." ; obo:SCDO_0000303 "Source needed for additional information." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000388" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000846" ; oboInOwl:hasDbXref "HP:0000388" ; a owl:Class ; rdfs:comment """is caused by: Usually bacterial but can be caused by fungus or virus infection. is characterised by: Pain or discharge from one or both ears""" ; rdfs:label "Otitis Media" ; rdfs:subClassOf obo:HP_0002715, obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:IDO_0000560 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0000478 obo:IAO_0000115 "Any abnormality of the eye, including location, spacing, and intraocular abnormalities." ; obo:SCDO_0000340 obo:HP_0000478 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000294" ; oboInOwl:hasDbXref "HP:0000478" ; a owl:Class ; rdfs:label "Abnormality of the Eye" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0000505 obo:IAO_0000115 "Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery." ; obo:SCDO_0000340 obo:HP_0000505 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000022" ; oboInOwl:hasDbXref "HP:0000505" ; oboInOwl:hasExactSynonym "Impaired Vision", "Impaired Visual Function", "Loss of Eyesight", "Poor Vision" ; a owl:Class ; rdfs:label "Visual Impairment" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319 . obo:HP_0000618 obo:IAO_0000115 "Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degress in radius around central fixation." ; obo:SCDO_0000340 obo:HP_0000618 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000021" ; oboInOwl:hasDbXref "HP:0000618" ; oboInOwl:hasExactSynonym "Total Vision Loss" ; a owl:Class ; rdfs:label "Blindness" ; rdfs:subClassOf obo:HP_0000505, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000707 obo:IAO_0000115 "Any abnormality of the nervous system." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000707" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009698" ; oboInOwl:hasDbXref "HP:0000707" ; oboInOwl:hasExactSynonym "Brain and/or Spinal Cord Issue", "Neurologic Abnormalities", "Neurological Abnormality" ; a owl:Class ; rdfs:label "Abnormality of the Nervous System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0000708 obo:IAO_0000115 "An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities." ; obo:SCDO_0000303 "Include \"Poor School Performance\" as a sub-class." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000708" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000105" ; oboInOwl:hasDbXref "HP:0000708" ; oboInOwl:hasExactSynonym "Behavioral Abnormality", "Behavioural Abnormality", "Behavioural Changes", "Behavioural Disorders", "Behavioural Disturbances", "Behavioural Problems", "Behavioural Symptoms", "Behavioural/Psychiatric Abnormalities", "Behavioural/Psychiatric Abnormality", "Psychiatric Disorders", "Psychiatric Disturbances" ; a owl:Class ; rdfs:label "Behavioural Abnormality" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0000726 obo:IAO_0000115 "A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior." ; obo:SCDO_0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0000726 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000345" ; oboInOwl:hasDbXref "HP:0000726" ; oboInOwl:hasExactSynonym "Dementia, Progressive", "Progressive Dementia" ; a owl:Class ; rdfs:label "Dementia" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ] . obo:HP_0000763 obo:IAO_0000115 "Peripheral neuropathy affecting the sensory nerves." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000763" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001038" ; oboInOwl:hasDbXref "HP:0000763" ; oboInOwl:hasExactSynonym "Peripheral Sensory Neuropathy" ; a owl:Class ; rdfs:label "Sensory Neuropathy" ; rdfs:subClassOf obo:HP_0009830 . obo:HP_0000789 obo:IAO_0000115 "Inability to produce live offspring." ; obo:SCDO_0000340 obo:MP_0001924 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000639" ; oboInOwl:hasDbXref "HP:0000789" ; oboInOwl:hasExactSynonym "Sterility" ; a owl:Class ; rdfs:label "Infertility" ; rdfs:subClassOf obo:HP_0000080, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0000798 obo:IAO_0000115 "Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen." ; obo:SCDO_0000340 obo:HP_0000798 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000827" ; oboInOwl:hasDbXref "HP:0000798" ; oboInOwl:hasExactSynonym "Low Sperm Count" ; a owl:Class ; rdfs:label "Oligospermia" ; rdfs:subClassOf obo:HP_0000080 . obo:HP_0000805 obo:IAO_0000115 "Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000805" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000434" ; oboInOwl:hasDbXref "HP:0000805" ; a owl:Class ; rdfs:label "Enuresis" ; rdfs:subClassOf obo:HP_0000079, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:HP_0000815 obo:IAO_0000115 "Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000815" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000586" ; oboInOwl:hasDbXref "HP:0000815" ; oboInOwl:hasExactSynonym "Hypergonadotrophic Hypogonadism", "Primary Hypogonadism" ; a owl:Class ; rdfs:label "Hypergonadotropic Hypogonadism" ; rdfs:subClassOf obo:HP_0000080, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0000818 obo:IAO_0000115 "An abnormality of the endocrine system." ; obo:SCDO_0000340 obo:HP_0000818 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002780" ; oboInOwl:hasDbXref "HP:0000818" ; a owl:Class ; rdfs:label "Abnormality of the Endocrine System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0000819 obo:IAO_0000115 "A group of abnormalities characterized by hyperglycemia and glucose intolerance." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000819" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000367" ; oboInOwl:hasDbXref "HP:0000819" ; a owl:Class ; rdfs:label "Diabetes Mellitus" ; rdfs:subClassOf obo:HP_0000818, obo:HP_0011014, obo:SCDO_0000267, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C15900 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0000820 obo:IAO_0000115 "An abnormality of the thyroid gland." ; obo:SCDO_0000340 obo:HP_0000820 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000278" ; oboInOwl:hasDbXref "HP:0000820" ; oboInOwl:hasExactSynonym "Thyroid Abnormality" ; a owl:Class ; rdfs:label "Abnormality of the Thyroid Gland" ; rdfs:subClassOf obo:HP_0000818 . obo:HP_0000821 obo:IAO_0000115 "Deficiency of thyroid hormone." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000821" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000603" ; oboInOwl:hasDbXref "HP:0000821" ; oboInOwl:hasExactSynonym "Low T4", "Underactive Thyroid" ; a owl:Class ; rdfs:label "Hypothyroidism" ; rdfs:subClassOf obo:HP_0000820, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000822 obo:IAO_0000115 "The presence of chronic increased pressure in the systemic arterial system." ; obo:SCDO_0000340 obo:HP_0000822 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008801" ; oboInOwl:hasDbXref "HP:0000822" ; a owl:Class ; rdfs:label "Hypertension" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0000823 obo:IAO_0000115 "Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty." ; obo:SCDO_0000340 obo:HP_0000823 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000342" ; oboInOwl:hasDbXref "HP:0000823" ; oboInOwl:hasExactSynonym "Delayed Development of Secondary Sex Characteristics", "Delayed Onset of Sexual Maturity", "Delayed Pubertal Development", "Delayed Sexual Maturation", "Delayed Sexual Maturity", "Delayed pubertal growth", "Pubertal Delay" ; a owl:Class ; rdfs:label "Delayed Puberty" ; rdfs:subClassOf obo:HP_0000818, obo:HP_0001507, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0000824 obo:IAO_0000115 "Insufficient production of growth hormone, which is produced by the anterior pituitary gland. Growth hormone is a major participant in control of growth and metabolism." ; obo:SCDO_0000340 obo:HP_0000824 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008218" ; oboInOwl:hasDbXref "HP:0000824" ; a owl:Class ; rdfs:label "Growth Hormone Deficiency" ; rdfs:subClassOf obo:HP_0000818 . obo:HP_0000828 obo:IAO_0000115 "An abnormality of the parathyroid gland." ; obo:SCDO_0000340 obo:HP_0000828 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000279" ; oboInOwl:hasDbXref "HP:0000828" ; a owl:Class ; rdfs:label "Abnormality of the Parathyroid Gland" ; rdfs:subClassOf obo:HP_0000818 . obo:HP_0000829 obo:IAO_0000115 "A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia." ; obo:SCDO_0000340 obo:HP_0000829 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007386" ; oboInOwl:hasDbXref "HP:0000829" ; oboInOwl:hasExactSynonym "Decreased Parathyroid Hormone Secretion", "Low Parathyroid Hormone" ; a owl:Class ; rdfs:label "Hypoparathyroidism" ; rdfs:subClassOf obo:HP_0000828 . obo:HP_0000834 obo:IAO_0000115 "Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kidneys." ; obo:SCDO_0000340 obo:HP_0000834 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007437" ; oboInOwl:hasDbXref "HP:0000834" ; oboInOwl:hasExactSynonym "Adrenal Abnormalities", "Adrenal Abnormality" ; a owl:Class ; rdfs:label "Abnormality of the Adrenal Glands" ; rdfs:subClassOf obo:HP_0000818 . obo:HP_0000836 obo:IAO_0000115 "An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3)." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000836" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000595" ; oboInOwl:hasDbXref "HP:0000836" ; oboInOwl:hasExactSynonym "Overactive Thyroid" ; a owl:Class ; rdfs:label "Hyperthyroidism" ; rdfs:subClassOf obo:HP_0000820 . obo:HP_0000842 obo:IAO_0000115 "An increased concentration of insulin in the blood." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000842" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000587" ; oboInOwl:hasDbXref "HP:0000842" ; oboInOwl:hasExactSynonym "Elevated Insulin Level" ; a owl:Class ; rdfs:label "Hyperinsulinemia" ; rdfs:subClassOf obo:HP_0000818, obo:HP_0011014, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ] . obo:HP_0000843 obo:IAO_0000115 "Excessive production of parathyroid hormone (PTH) by the parathyroid glands." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000843" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000592" ; oboInOwl:hasDbXref "HP:0000843" ; oboInOwl:hasExactSynonym "Elevated Blood Parathyroid Hormone Level" ; a owl:Class ; rdfs:label "Hyperparathyroidism" ; rdfs:subClassOf obo:HP_0000828, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0000855 obo:IAO_0000115 "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000855" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000644" ; oboInOwl:hasDbXref "HP:0000855" ; oboInOwl:hasExactSynonym "Body Fails to Respond to Insulin" ; a owl:Class ; rdfs:label "Insulin Resistance" ; rdfs:subClassOf obo:HP_0011014, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000498 ] . obo:HP_0000873 obo:IAO_0000115 "A state of excessive water excretion and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000873" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000366" ; oboInOwl:hasDbXref "HP:0000873" ; a owl:Class ; rdfs:label "Diabetes Insipidus" ; rdfs:subClassOf obo:HP_0000818 . obo:HP_0000876 obo:IAO_0000115 "Infrequent menses (less than 6 per year or more than 35 days between cycles)." ; obo:SCDO_0000340 obo:HP_0000876 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003158" ; oboInOwl:hasDbXref "HP:0000876" ; oboInOwl:hasExactSynonym "Light or Infrequent Menstrual Periods" ; a owl:Class ; rdfs:label "Oligomenorrhea" ; rdfs:subClassOf obo:HP_0012243 . obo:HP_0000924 obo:IAO_0000115 "An abnormality of the skeletal system." ; obo:SCDO_0000340 obo:HP_0000924 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006301" ; oboInOwl:hasDbXref "HP:0000924" ; oboInOwl:hasExactSynonym "Skeletal Abnormalities", "Skeletal Anomalies" ; a owl:Class ; rdfs:label "Abnormality of the Skeletal System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0000938 obo:IAO_0000115 "Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000938" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000843" ; oboInOwl:hasDbXref "HP:0000938" ; oboInOwl:hasExactSynonym "Decreased Bone Mineral Density", "Generalized Osteopenia" ; a owl:Class ; rdfs:label "Osteopenia" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000382 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000498 ] . obo:HP_0000939 obo:IAO_0000115 "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD)." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000939" ; obo:SCDO_0000661 "Genetic predisposition, low calcium diet, getting little exercise, smoking, decrease in estrogen at the menopause, steroid medicine use for a long time, Vitamin D insufficiency." ; obo:SCDO_0000662 "Bone pain, backache, gradual loss of height, stooped posture, fractures." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000844" ; oboInOwl:hasDbXref "HP:0000939" ; a owl:Class ; rdfs:label "Osteoporosis" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000951 obo:IAO_0000115 "An abnormality of the skin." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000951" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008348" ; oboInOwl:hasDbXref "HP:0000951" ; oboInOwl:hasExactSynonym "Abnormal skin morphology", "Abnormal skin structure", "Dermatopathy", "Dermopathy", "Skin Abnormality" ; a owl:Class ; rdfs:label "Abnormality of the Skin" ; rdfs:subClassOf obo:HP_0001574 . obo:HP_0000952 obo:IAO_0000115 "Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000952" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000671" ; oboInOwl:hasDbXref "HP:0000952" ; oboInOwl:hasExactSynonym "Icterus", "Yellow Skin", "Yellowing of the Skin" ; a owl:Class ; rdfs:label "Jaundice" ; rdfs:subClassOf obo:HP_0011121, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:HP_0000953 obo:IAO_0000115 "A darkening of the skin related to an increase in melanin production and deposition." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000953" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000308" ; oboInOwl:hasDbXref "HP:0000953" ; oboInOwl:hasExactSynonym "Hyperpigmentation of the Skin", "Increased Skin Pigmentation", "Melanoderma", "Melanodermia", "Skin Hyperpigmentation" ; a owl:Class ; rdfs:label "Cutaneous Hyperpigmentation" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0000961 obo:IAO_0000115 "Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood." ; obo:SCDO_0000340 obo:HP_0000961 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000309" ; oboInOwl:hasDbXref "HP:0000961" ; oboInOwl:hasExactSynonym "Blue Discoloration of the Skin", "Cyanotic" ; a owl:Class ; rdfs:label "Cyanosis" ; rdfs:subClassOf obo:HP_0011121, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0000962 obo:IAO_0000115 "Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum." ; obo:SCDO_0000340 obo:HP_0000962 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000589" ; oboInOwl:hasDbXref "HP:0000962" ; a owl:Class ; rdfs:label "Hyperkeratosis" ; rdfs:subClassOf obo:HP_0011121, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0000967 obo:IAO_0000115 "Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae." ; obo:SCDO_0000340 obo:HP_0000967 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000892" ; oboInOwl:hasDbXref "HP:0000967" ; a owl:Class ; rdfs:label "Petechiae" ; rdfs:subClassOf obo:HP_0002597, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0000969 obo:IAO_0000115 "An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000969" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000823" ; oboInOwl:hasDbXref "HP:0000969" ; oboInOwl:hasExactSynonym "Dropsy", "Fluid Retention", "Hydrops", "Oedema", "Water Retention" ; a owl:Class ; rdfs:label "Edema" ; rdfs:subClassOf obo:SCDO_0002674, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0000980 obo:IAO_0000115 "Abnormally pale skin." ; obo:SCDO_0000340 obo:HP_0000980 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000863" ; oboInOwl:hasDbXref "HP:0000980" ; a owl:Class ; rdfs:label "Pallor" ; rdfs:subClassOf obo:HP_0011121, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0000999 obo:IAO_0000115 "Any manifestation of a skin disease associated with the production of pus." ; obo:SCDO_0000340 obo:HP_0000999 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000946" ; oboInOwl:hasDbXref "HP:0000999" ; oboInOwl:hasExactSynonym "Pus-Filled Lesion" ; a owl:Class ; rdfs:label "Pyoderma" ; rdfs:subClassOf obo:HP_0002715, obo:HP_0011122, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ] . obo:HP_0001010 obo:IAO_0000115 "A reduction of skin color related to a decrease in melanin production and deposition." ; obo:SCDO_0000340 obo:HP_0001010 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000601" ; oboInOwl:hasDbXref "HP:0001010" ; oboInOwl:hasExactSynonym "Hypopigmentation of the Skin", "Hypopigmented Skin", "Skin Hypopigmentation" ; a owl:Class ; rdfs:label "Hypopigmentation" ; rdfs:subClassOf obo:HP_0011121 . obo:HP_0001022 obo:IAO_0000115 "An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina)." ; obo:SCDO_0000340 obo:HP_0001022 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000036" ; oboInOwl:hasDbXref "HP:0001022" ; oboInOwl:hasExactSynonym "Achromasia" ; a owl:Class ; rdfs:label "Albinism" ; rdfs:subClassOf obo:HP_0001010 . obo:HP_0001025 obo:IAO_0000115 "Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure." ; obo:SCDO_0000340 obo:HP_0001025 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001219" ; oboInOwl:hasDbXref "HP:0001025" ; oboInOwl:hasExactSynonym "Hives" ; a owl:Class ; rdfs:label "Urticaria" ; rdfs:subClassOf obo:HP_0002597 . obo:HP_0001061 obo:IAO_0000115 "A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts)." ; obo:SCDO_0000340 obo:HP_0001061 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000012" ; oboInOwl:hasDbXref "HP:0001061" ; oboInOwl:hasExactSynonym "Break Out", "Breaking Out" ; a owl:Class ; rdfs:label "Acne" ; rdfs:subClassOf obo:HP_0011123, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0001081 obo:IAO_0000115 "Hard, pebble-like deposits that form within the gallbladder." ; obo:SCDO_0000303 "Add here \"bilirubin gallstones\" (see paper \"Liver involvement in sickle cell disease\" by Emel GÜRKAN et al.). in HP these are called \"Pigment Gallstones\"." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001081" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007091" ; oboInOwl:hasDbXref "HP:0001081" ; oboInOwl:hasExactSynonym "Gallstones" ; a owl:Class ; rdfs:label "Cholelithiasis" ; rdfs:subClassOf obo:HP_0025031, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:ARO_0000064 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:CHEBI_6909 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C519 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0001197 obo:IAO_0000115 "An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities." ; obo:SCDO_0000340 obo:HP_0001197 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000262" ; oboInOwl:hasDbXref "HP:0001197" ; a owl:Class ; rdfs:label "Abnormality of Prenatal Development or Birth" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0001250 obo:IAO_0000115 "Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001250" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001030" ; oboInOwl:hasDbXref "HP:0001250" ; oboInOwl:hasExactSynonym "Seizures" ; a owl:Class ; rdfs:label "Seizure" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001254 obo:IAO_0000115 "A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating." ; obo:SCDO_0000340 obo:HP_0001254 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003089" ; oboInOwl:hasDbXref "HP:0001254" ; a owl:Class ; rdfs:label "Lethargy" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0001260 obo:IAO_0000115 "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." ; obo:SCDO_0000303 "- Use description to add sub-classes of types of Dysarthria? -- Use text in comments to add relevant terms regarding disease progression? And link to these terms with relevant object property" ; obo:SCDO_0000340 obo:HP_0001260 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000403" ; oboInOwl:hasDbXref "HP:0001260" ; oboInOwl:hasExactSynonym "Difficulty Articulating Speech", "Dysarthric Speech" ; a owl:Class ; rdfs:label "Dysarthria" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001265 obo:IAO_0000115 "Reduction of neurologic reflexes such as the knee-jerk reaction." ; obo:SCDO_0000340 obo:HP_0001265 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000602" ; oboInOwl:hasDbXref "HP:0001265" ; oboInOwl:hasExactSynonym "Decreased Reflex Response", "Decreased Reflexes" ; a owl:Class ; rdfs:label "Hyporeflexia" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0001269 obo:IAO_0000115 "Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001269" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008272" ; oboInOwl:hasDbXref "HP:0001269" ; oboInOwl:hasExactSynonym "Weakness of One Side of Body" ; a owl:Class ; rdfs:label "Hemiparesis" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0001271 obo:IAO_0000115 "A generalized disorder of peripheral nerves." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001271" ; obo:SCDO_0000661 """Acute polyneuropathy has many causes: Infections involving a toxin produced by bacteria, as occurs in diphtheria,An autoimmune reaction (when the body attacks its own tissues), as occurs in Guillain-Barré syndrome (see Guillain-Barré Syndrome), Drugs, including the anticonvulsant phenytoin, some antibiotics (such as chloramphenicol, nitrofurantoin, and sulfonamides), some chemotherapy drugs (such as vinblastine and vincristine), and some sedatives (such as barbital and hexobarbital), Cancer (such as multiple myeloma), which damages nerves by directly invading or putting pressure on them or by triggering an autoimmune reaction, Certain toxins, such as organophosphate insecticides, triorthocresyl phosphate (TOCP), and thallium The cause of chronic polyneuropathy is often unknown. Known causes include the following: Diabetes Mellitus, Excessive use of alcohol, Nutritional deficiencies (such as thiamin deficiency), an uncommon cause in the United States, except among alcoholics who are malnourished, Vitamin B12 deficiency, which causes subacute combined degeneration of the spinal cord (see Subacute Combined Degeneration) and often pernicious anemia (see Inadequate absorption), An underactive thyroid gland (hypothyroidism), Toxic substances, including heavy metals such as lead and mercury, Kidney failure, Certain cancers, such as lung cancer, Rarely, vitamin B6 (pyridoxine) taken in excessive amounts.""" ; obo:SCDO_0000662 "Acute polyneuropathy (as occurs in Guillain-Barré syndrome) begins suddenly in both legs and progresses rapidly upward to the arms. Symptoms include weakness and a pins-and-needles sensation or loss of sensation. The muscles that control breathing may be affected, resulting in respiratory failure.In the most common form of chronic polyneuropathy, only sensation is affected. Usually, the feet are affected first, but sometimes the hands are. A pins-and-needles sensation, numbness, burning pain, and loss of vibration sense and position sense (knowing where the arms and legs are) are prominent symptoms. Because position sense is lost, walking and even standing become unsteady. Consequently, muscles may not be used. Eventually, they may weaken and waste away. Then, muscles may become stiff and permanently shortened (called contractures). Diabetic neuropathy commonly causes painful tingling or burning sensations in the hands and feet-a condition called distal polyneuropathy. Pain is often worse at night and may be aggravated by touch or by a change in temperature. People may lose the senses of temperature and pain, so they often burn themselves and may have open sores caused by prolonged pressure or other injuries. Without pain as a warning of too much stress, joints are susceptible to injuries. This type of injury is called neurogenic arthropathy (Charcot joints) Polyneuropathy often affects the nerves of the autonomic nervous system, which controls involuntary functions in the body (such as blood pressure, heart rate, digestion, salivation, and urination). Typical symptoms are constipation, sexual dysfunction, and fluctuating blood pressure-most notably a sudden fall in blood pressure when a person stands up (orthostatic hypotension). The skin may become pale and dry, and sweating may be reduced. Much less often, control of bowel movements or urination is lost, leading to fecal or urinary incontinence." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000914" ; dc:source , ; oboInOwl:hasDbXref "HP:0001271" ; oboInOwl:hasExactSynonym "Peripheral Nerve Disease" ; a owl:Class ; rdfs:label "Polyneuropathy" ; rdfs:subClassOf obo:HP_0009830, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C85397 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000822 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0001279 obo:IAO_0000115 "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001279" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008553" ; oboInOwl:hasDbXref "HP:0001279" ; oboInOwl:hasExactSynonym "Fainting Spell" ; a owl:Class ; rdfs:label "Syncope" ; rdfs:subClassOf obo:HP_0011025, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001287 obo:IAO_0000115 "Inflammation of the meninges." ; obo:SCDO_0000340 obo:HP_0001287 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000744" ; oboInOwl:hasDbXref "HP:0001287" ; a owl:Class ; rdfs:label "Meningitis" ; rdfs:subClassOf obo:HP_0002715, obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0001289 obo:IAO_0000115 "Lack of clarity and coherence of thought, perception, understanding, or action." ; obo:SCDO_0000303 "-- Perhaps move below \"Behavioral Abnormality\"?" ; obo:SCDO_0000340 obo:HP_0001289 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000273" ; oboInOwl:hasDbXref "HP:0001289" ; a owl:Class ; rdfs:label "Confusion" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0001298 obo:IAO_0000115 "A term that means brain disease, damage, or malfunction. In general, it is manifested by an altered mental state." ; obo:SCDO_0000303 "-- Provide source for additional info. -- -- Specify which Blood Tests and Which Imaging Tests are used to diagnose." ; obo:SCDO_0000340 obo:HP_0001298 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000429" ; oboInOwl:hasDbXref "HP:0001298" ; a owl:Class ; rdfs:label "Encephalopathy" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OBI_0000185 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000420 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000382 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000983 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0001342 obo:IAO_0000115 "Hemorrhage into the parenchyma of the brain." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001342" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000209" ; oboInOwl:hasDbXref "HP:0001342" ; oboInOwl:hasExactSynonym "Bleeding in Brain", "Hemorrhagic Stroke", "Intracerebral Bleeding", "Intracerebral Hemorrhage" ; a owl:Class ; rdfs:label "Cerebral Hemorrhage" ; rdfs:subClassOf obo:HP_0002170, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OBI_0000185 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001327 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000822 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0001343 obo:IAO_0000115 "Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction." ; obo:SCDO_0000340 obo:HP_0001343 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000673" ; oboInOwl:hasDbXref "HP:0001343" ; a owl:Class ; rdfs:label "Kernicterus" ; rdfs:subClassOf obo:HP_0012639 . obo:HP_0001369 obo:IAO_0000115 "Inflammation of a joint." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001369" ; obo:SCDO_0000468 "Any age" ; obo:SCDO_0000661 "Infection (bacteria), ischemia, joint injury (trauma, surgery), degeneration." ; obo:SCDO_0000662 "Joint pain, joint swelling, stiffness, lack of function." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000075" ; oboInOwl:hasDbXref "HP:0001369" ; oboInOwl:hasExactSynonym "Joint Inflammation" ; a owl:Class ; rdfs:label "Arthritis" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:HP_0001370 obo:IAO_0000115 "An autoimmune response that primarily affects connective tissue; it also results in chronic inflammation of the joints, especially of the hands and feet and may also cause inflammation of the tissue around the joints, as well as other organs in the body." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MP_0003561" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001011" ; oboInOwl:hasDbXref "HP:0001370" ; oboInOwl:hasExactSynonym "Osteoarthrosis Deformans", "RA" ; a owl:Class ; rdfs:label "Rheumatoid Arthritis" ; rdfs:subClassOf obo:HP_0001369, obo:HP_0002715, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000822 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001371 obo:IAO_0000115 "A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001371" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001324" ; oboInOwl:hasDbXref "HP:0001371" ; oboInOwl:hasExactSynonym "Flexion Contractures", "Flexion Contractures of Joints", "Joint Contracture", "Joint Contractures" ; a owl:Class ; rdfs:label "Flexion Contracture" ; rdfs:subClassOf obo:HP_0000924 . obo:HP_0001382 obo:IAO_0000115 "The ability of a joint to move beyond its normal range of motion." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001382" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000672" ; oboInOwl:hasDbXref "HP:0001382" ; oboInOwl:hasExactSynonym "Double-Jointed", "Hyperextensible Joints", "Increased Mobility of Joints", "Joint Hyperextensibility" ; a owl:Class ; rdfs:label "Joint Hypermobility" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ] . obo:HP_0001392 obo:IAO_0000115 "An abnormality of the liver." ; obo:SCDO_0000340 obo:HP_0001392 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000272" ; oboInOwl:hasDbXref "HP:0001392" ; oboInOwl:hasExactSynonym "Complication of the Liver", "Liver Abnormality", "Liver Complication" ; a owl:Class ; rdfs:label "Abnormality of the Liver" ; rdfs:subClassOf obo:HP_0025031 . obo:HP_0001394 obo:IAO_0000115 "A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function." ; obo:SCDO_0000340 obo:HP_0001394 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001488" ; oboInOwl:hasDbXref "HP:0001394" ; oboInOwl:hasExactSynonym "Hepatic Cirrhosis", "Scar Tissue Replaces Healthy Tissue in the Liver" ; a owl:Class ; rdfs:label "Cirrhosis" ; rdfs:subClassOf obo:HP_0001392 . obo:HP_0001395 obo:IAO_0000115 "The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process." ; obo:SCDO_0000340 obo:HP_0001395 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001493" ; oboInOwl:hasDbXref "HP:0001395" ; a owl:Class ; rdfs:label "Hepatic Fibrosis" ; rdfs:subClassOf obo:HP_0001392 . obo:HP_0001406 obo:IAO_0000115 "Impairment of bile flow due to obstruction in the small bile ducts within the liver." ; obo:SCDO_0000303 "Is managed by: analgesia, hydration, antibiotics, and in severe cases exchange transfusion may be needed." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001406" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009774" ; oboInOwl:hasDbXref "HP:0001406" ; a owl:Class ; rdfs:label "Intrahepatic Cholestasis" ; rdfs:subClassOf obo:HP_0001392, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001433 obo:IAO_0000115 "Simultaneous enlargement of the liver and spleen." ; obo:SCDO_0000340 obo:HP_0001433 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007326" ; oboInOwl:hasDbXref "HP:0001433" ; a owl:Class ; rdfs:label "Hepatosplenomegaly" ; rdfs:subClassOf obo:HP_0001392, obo:HP_0001743, obo:NCIT_C115224 . obo:HP_0001507 obo:IAO_0000115 "Abnormality of growth." ; obo:SCDO_0000340 obo:HP_0001507 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000271" ; oboInOwl:hasDbXref "HP:0001507" ; oboInOwl:hasExactSynonym "Abnormal Growth", "Growth Issue" ; a owl:Class ; rdfs:label "Growth Abnormality" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0001508 obo:IAO_0000115 "Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm." ; obo:SCDO_0000340 obo:HP_0001508 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002729" ; oboInOwl:hasDbXref "HP:0001508" ; oboInOwl:hasExactSynonym "FTT", "Faltering Weight", "Poor Weight Gain", "Postnatal Failure to Thrive", "Undergrowth", "Weight Faltering" ; a owl:Class ; rdfs:label "Failure to Thrive" ; rdfs:subClassOf obo:HP_0001507 . obo:HP_0001511 obo:IAO_0000115 "An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001511" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000658" ; oboInOwl:hasDbXref "HP:0001511" ; oboInOwl:hasExactSynonym "IUGR", "Intrauterine Growth Retardation", "Prenatal Growth Retardation", "Prenatal-Onset Growth Retardation", "Small for Gestational Age Infant" ; a owl:Class ; rdfs:label "Intrauterine Growth Restriction" ; rdfs:subClassOf obo:HP_0001197, obo:HP_0001507, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001513 obo:IAO_0000115 "Body weight that is grossly above the acceptable or desirable weight, usually due to accumulation of excess fats in the body. The standards may vary with age, sex, genetic or cultural background. In the body mass index (BMI), a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001513" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000816" ; oboInOwl:hasDbXref "HP:0001513" ; oboInOwl:hasExactSynonym "Having too much body fat" ; a owl:Class ; rdfs:label "Obesity" ; rdfs:subClassOf obo:HP_0001507, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001284 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001574 obo:IAO_0000115 "An abnormality of the integument, which consists of the skin and the superficial fascia." ; obo:SCDO_0000340 obo:HP_0001574 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000274" ; oboInOwl:hasDbXref "HP:0001574" ; a owl:Class ; rdfs:label "Abnormality of the Integument" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0001622 obo:IAO_0000115 "The birth of a baby of less than 37 weeks of gestational age." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001622" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000920" ; oboInOwl:hasDbXref "HP:0001622" ; oboInOwl:hasExactSynonym "Premature Birth", "Premature Delivery", "Premature Delivery of Affected Infants", "Preterm Birth" ; a owl:Class ; rdfs:label "Preterm Delivery" ; rdfs:subClassOf obo:HP_0001197, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0001626 obo:IAO_0000115 "Any abnormality of the cardiovascular system." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001626" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002245" ; oboInOwl:hasDbXref "HP:0001626" ; oboInOwl:hasExactSynonym "Abnormality of the Cardiovascular System", "Cardiovascular Abnormality" ; a owl:Class ; rdfs:label "Abnormality of Cardiovascular System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0001635 obo:IAO_0000115 "The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004877" ; oboInOwl:hasDbXref "HP:0001635" ; oboInOwl:hasExactSynonym "CHF", "Cardiac Insufficiency,", "Congestive Heart Failure", "Heart Failure" ; a owl:Class ; rdfs:label "Cardiac Failure" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0001640 obo:IAO_0000115 "Increased size of the heart." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001640" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008273" ; oboInOwl:hasDbXref "HP:0001640" ; oboInOwl:hasExactSynonym "Enlarged Heart", "Increased Heart Size" ; a owl:Class ; rdfs:label "Cardiomegaly" ; rdfs:subClassOf obo:HP_0030680, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:HP_0001658 obo:IAO_0000115 "Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001658" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007991" ; oboInOwl:hasDbXref "HP:0001658" ; a owl:Class ; rdfs:label "Myocardial Infarction" ; rdfs:subClassOf obo:HP_0011025, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0001701 obo:IAO_0000115 "Inflammation of the sac-like covering around the heart (pericardium)." ; obo:SCDO_0000340 obo:HP_0001701 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003765" ; oboInOwl:hasDbXref "HP:0001701" ; a owl:Class ; rdfs:label "Pericarditis" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0001712 obo:IAO_0000115 "Enlargement or increased size of the heart left ventricle." ; obo:SCDO_0000340 obo:HP_0001712 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002803" ; oboInOwl:hasDbXref "HP:0001712" ; oboInOwl:hasExactSynonym "Heart Left Ventricle Hypertrophy", "Left Ventricular Wall Hypertrophy" ; a owl:Class ; rdfs:label "Left Ventricular Hypertrophy" ; rdfs:subClassOf obo:HP_0001714 . obo:HP_0001714 obo:IAO_0000115 "Enlargement of the cardiovascular ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001714" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001231" ; oboInOwl:hasDbXref "HP:0001714" ; a owl:Class ; rdfs:label "Ventricular Hypertrophy" ; rdfs:subClassOf obo:HP_0030680, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:HP_0001743 obo:IAO_0000115 "An abnormality of the spleen." ; obo:SCDO_0000340 obo:HP_0001743 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000370" ; oboInOwl:hasDbXref "HP:0001743" ; a owl:Class ; rdfs:label "Abnormality of the Spleen" ; rdfs:subClassOf obo:HP_0002715, obo:HP_0025031 . obo:HP_0001744 obo:IAO_0000115 "Abnormal increased size of the spleen." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001744" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005287" ; oboInOwl:hasDbXref "HP:0001744" ; oboInOwl:hasExactSynonym "Increased Spleen Size" ; a owl:Class ; rdfs:comment "Results from splenic sequestration" ; rdfs:label "Splenomegaly" ; rdfs:subClassOf obo:HP_0001743, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0001787 obo:IAO_0000115 "An abnormality of the birth process." ; obo:SCDO_0000340 obo:HP_0001787 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000372" ; oboInOwl:hasDbXref "HP:0001787" ; a owl:Class ; rdfs:label "Abnormal Delivery" ; rdfs:subClassOf obo:HP_0001197 . obo:HP_0001789 obo:IAO_0000115 "The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001789" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000578" ; oboInOwl:hasDbXref "HP:0001789" ; a owl:Class ; rdfs:label "Hydrops Fetalis" ; rdfs:subClassOf obo:HP_0000969, obo:HP_0001197, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001303 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:HP_0001871 obo:IAO_0000115 "An abnormality of the hematopoietic system." ; obo:SCDO_0000340 obo:HP_0001871 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000264" ; oboInOwl:hasDbXref "HP:0001871" ; oboInOwl:hasExactSynonym "Abnormality of the Hematopoietic System", "Hematological Abnormality", "Hematopoietic System Abnormality" ; a owl:Class ; rdfs:label "Abnormality of Blood and Blood-Forming Tissues" ; rdfs:subClassOf obo:HP_0000118, obo:SCDO_1000820 . obo:HP_0001872 obo:IAO_0000115 "An abnormality of platelets. Platelets, also known as thrombocytes, are non-nucleated disk-shaped cells mainly involved in blood coagulation." ; obo:SCDO_0000340 obo:HP_0001872 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000616" ; oboInOwl:hasDbXref "HP:0001872" ; oboInOwl:hasExactSynonym "Platelet Abnormalities" ; a owl:Class ; rdfs:label "Abnormal Thrombocyte Morphology" ; rdfs:subClassOf obo:HP_0001871 . obo:HP_0001873 obo:IAO_0000115 "A reduction in the number of circulating thrombocytes." ; obo:SCDO_0000340 obo:HP_0001873 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002700" ; oboInOwl:hasDbXref "HP:0001873" ; a owl:Class ; rdfs:label "Thrombocytopenia" ; rdfs:subClassOf obo:HP_0011873 . obo:HP_0001874 obo:IAO_0000115 "A neutrophil abnormality." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000440" ; oboInOwl:hasDbXref "HP:0001874" ; a owl:Class ; rdfs:comment "Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defense during inflammation and infections. They are myeloid granulocytes and their names is derived from the fact that their cytoplasm contains granules that stain with acidic dye as well as granules that stain with basic dye. Their nuclei consist of three to five lobes connected by slender threads of chromatin. Mature neutrophils live for approximately one day." ; rdfs:label "Abnormality of Neutrophils" ; rdfs:subClassOf obo:HP_0001871 . obo:HP_0001875 obo:IAO_0000115 "An abnormally low number of neutrophils in the peripheral blood." ; obo:SCDO_0000340 obo:HP_0001875 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009334" ; oboInOwl:hasDbXref "HP:0001875" ; oboInOwl:hasExactSynonym "Decreased Neutrophil Count", "Low Blood Neutrophil Count", "Low Neutrophil Count", "Peripheral Neutropenia" ; a owl:Class ; rdfs:label "Neutropenia" ; rdfs:subClassOf obo:HP_0011991 . obo:HP_0001877 obo:IAO_0000115 "Any structural abnormality of erythrocytes (red-blood cells)." ; obo:SCDO_0000340 obo:HP_0001877 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000285" ; oboInOwl:hasDbXref "HP:0001877" ; a owl:Class ; rdfs:label "Abnormal Erythrocyte Morphology" ; rdfs:subClassOf obo:HP_0001871 . obo:HP_0001878 obo:IAO_0000115 "A type of anemia caused by premature destruction of red blood cells (hemolysis)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001878" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003844" ; oboInOwl:hasDbXref "HP:0001878" ; a owl:Class ; rdfs:label "Hemolytic Anemia" ; rdfs:subClassOf obo:HP_0001903, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0001882 obo:IAO_0000115 "An abnormal decreased number of leukocytes in the blood." ; obo:SCDO_0000340 obo:HP_0001882 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000614" ; oboInOwl:hasDbXref "HP:0001882" ; oboInOwl:hasExactSynonym "Decreased Blood Leukocyte Number", "Low White Blood Cell Count" ; a owl:Class ; rdfs:label "Leukopenia" ; rdfs:subClassOf obo:HP_0011893 . obo:HP_0001889 obo:IAO_0000115 "Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001889" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005864" ; oboInOwl:hasDbXref "HP:0001889" ; a owl:Class ; rdfs:label "Megaloblastic Anemia" ; rdfs:subClassOf obo:HP_0001903, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0001894 obo:IAO_0000115 "Thrombocythemia and thrombocytosis are conditions with a higher than normal number of platelets. The term \"thrombocythemia\" is preferred when the cause of a high platelet count isn't known. The condition sometimes is called primary or essential thrombocythemia. Increased numbers of platelets in the peripheral blood." ; obo:SCDO_0000340 obo:HP_0001894 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000618" ; oboInOwl:hasDbXref "HP:0001894" ; oboInOwl:hasExactSynonym "Increased Number of Platelets in Blood", "Increased Platelet Count" ; a owl:Class ; rdfs:label "Thrombocytosis" ; rdfs:subClassOf obo:HP_0011873 . obo:HP_0001896 obo:IAO_0000115 "A reduced number of reticulocytes in the peripheral blood." ; obo:SCDO_0000340 obo:HP_0001896 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001423" ; oboInOwl:hasDbXref "HP:0001896" ; oboInOwl:hasExactSynonym "Low Reticulocyte Count", "Reduced Number of Reticulocytes", "Reduced Reticulocyte Count" ; a owl:Class ; rdfs:label "Reticulocytopenia" ; rdfs:subClassOf obo:HP_0004312, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:HP_0001903 obo:IAO_0000115 "A reduction in erythrocytes volume or hemoglobin concentration." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001903" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005660" ; oboInOwl:hasDbXref "HP:0001903" ; a owl:Class ; rdfs:label "Anemia" ; rdfs:subClassOf obo:HP_0001877, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0001909 obo:IAO_0000115 "A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001909" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000687" ; oboInOwl:hasDbXref "HP:0001909" ; oboInOwl:hasExactSynonym "Blood Cancer" ; a owl:Class ; rdfs:label "Leukaemia" ; rdfs:subClassOf obo:OBI_1110053, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0001919 obo:IAO_0000115 "Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia)." ; obo:SCDO_0000303 "Further work", "Provide source for additional info.", "There is conflicting positioning of this term in different ontologies. Need an expert to decide descriptions and positioning of this and related terms." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001919" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000017" ; oboInOwl:hasDbXref "HP:0001919" ; oboInOwl:hasExactSynonym "Acute Kidney Failure", "Acute Renal Failure" ; a owl:Class ; rdfs:comment "Acute renal failure is usually classified into prerenal (response to severe volume depletion), intrinsic (response to acute cytotoxic, ischemic, or inflammatory insults) and postrenal (response to obstruction of the passage of urine) etiologies." ; rdfs:label "Acute Kidney Injury" ; rdfs:subClassOf obo:HP_0000084, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000983 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000256 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0000457 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0001920 obo:IAO_0000115 "The presence of stenosis of the renal artery." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0001920 ; obo:SCDO_0000468 "If due to FMD, presents at younger age, typically between 25-50 (and more common in women); if related to atherosclerotic disase, more likely to present after age 50." ; obo:SCDO_0000661 "May be caused by atherosclerotic disease, fibromuscular dysplasia." ; obo:SCDO_0000662 "Reduced blood flow through the renal arteries, large and branching vessels." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000982" ; oboInOwl:hasDbXref "HP:0001920" ; oboInOwl:hasExactSynonym "Narrowing of Kidney Artery", "RAS" ; a owl:Class ; rdfs:label "Renal Artery Stenosis" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0001923 obo:IAO_0000115 "An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation." ; obo:SCDO_0000340 obo:HP_0001923 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001272" ; oboInOwl:hasDbXref "HP:0001923" ; oboInOwl:hasExactSynonym "High Reticulocyte Count", "Increased Immature Red Blood Cells", "Increased Number of Immature Red Blood Cells", "Increased Reticulocyte Count", "Increased Reticulocytes" ; a owl:Class ; rdfs:label "Reticulocytosis" ; rdfs:subClassOf obo:HP_0004312, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0009350 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ] . obo:HP_0001931 obo:IAO_0000115 "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes." ; obo:SCDO_0000340 obo:HP_0001931 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007371" ; oboInOwl:hasDbXref "HP:0001931" ; a owl:Class ; rdfs:label "Hypochromic Anemia" ; rdfs:subClassOf obo:HP_0001903 . obo:HP_0001935 obo:IAO_0000115 "A kind of anemia in which the volume of the red blood cells is reduced." ; obo:SCDO_0000340 obo:HP_0001935 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008538" ; dc:source obo:HP_0001935 ; oboInOwl:hasDbXref "HP:0001935" ; a owl:Class ; rdfs:comment "In normocytic anemia, the mean corpuscular volume (MCV) is below normal limits (>80 fl in adults)." ; rdfs:label "Microcytic Anemia" ; rdfs:subClassOf obo:HP_0001903 . obo:HP_0001943 obo:IAO_0000115 "A decreased concentration of glucose in the blood." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001943" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000599" ; oboInOwl:hasDbXref "HP:0001943" ; oboInOwl:hasExactSynonym "Low Blood Sugar" ; a owl:Class ; rdfs:label "Hypoglycemia" ; rdfs:subClassOf obo:HP_0011014 . obo:HP_0001953 obo:IAO_0000115 "A type of diabetic metabolic abnormality with an accumulation of ketone bodies." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001953" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000369" ; oboInOwl:hasDbXref "HP:0001953" ; oboInOwl:hasExactSynonym "Diabetic Ketosis" ; a owl:Class ; rdfs:label "Diabetic Ketoacidosis" ; rdfs:subClassOf obo:HP_0000819, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000576 ] . obo:HP_0001970 obo:IAO_0000115 "A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." ; obo:SCDO_0000340 obo:HP_0001970 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000652" ; oboInOwl:hasDbXref "HP:0001970" ; oboInOwl:hasExactSynonym "Tubulointerstitial Nephritis" ; a owl:Class ; rdfs:label "Interstitial Nephritis" ; rdfs:subClassOf obo:HP_0000123, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0001974 obo:IAO_0000115 "An abnormal increase in the number of leukocytes in the blood." ; obo:SCDO_0000340 obo:HP_0001974 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005790" ; oboInOwl:hasDbXref "HP:0001974" ; oboInOwl:hasExactSynonym "Elevated White Blood Count", "High White Blood Count", "Increased Blood Leukocyte Number" ; a owl:Class ; rdfs:label "Leukocytosis" ; rdfs:subClassOf obo:HP_0011893 . obo:HP_0001977 obo:IAO_0000115 "Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis)." ; obo:SCDO_0000340 obo:HP_0001977 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000287" ; oboInOwl:hasDbXref "HP:0001977" ; a owl:Class ; rdfs:label "Abnormal Thrombosis" ; rdfs:subClassOf obo:HP_0001871 . obo:HP_0001999 obo:IAO_0000115 "An abnormal morphology (form) of the face or its components." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001999" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001314" ; oboInOwl:hasDbXref "HP:0001999" ; oboInOwl:hasExactSynonym "Abnormal Morphology of the Face", "Abnormal facial shape", "Dysmorphic Facial Features", "Unusual Facial Appearance" ; a owl:Class ; rdfs:label "Facial Dysmorphisms" ; rdfs:subClassOf obo:HP_0000271 . obo:HP_0002007 obo:IAO_0000115 "Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002007" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001337" ; oboInOwl:hasDbXref "HP:0002007" ; oboInOwl:hasExactSynonym "Frontal Protruberance", "Skull Bossing" ; a owl:Class ; rdfs:label "Frontal Bossing" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0002014 obo:IAO_0000115 "Abnormally increased frequency of loose or watery bowel movements." ; obo:SCDO_0000340 obo:HP_0002014 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008043" ; oboInOwl:hasDbXref "HP:0002014" ; oboInOwl:hasExactSynonym "Diarrhoea", "Watery stool" ; a owl:Class ; rdfs:label "Diarrhea" ; rdfs:subClassOf obo:HP_0025031 . obo:HP_0002019 obo:IAO_0000115 "Infrequent or difficult evacuation of feces." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002019" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003263" ; oboInOwl:hasDbXref "HP:0002019" ; oboInOwl:hasExactSynonym "Constipation", "Costiveness", "Dyschezia" ; a owl:Class ; rdfs:label "Constipation" ; rdfs:subClassOf obo:HP_0025031, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0002059 obo:IAO_0000115 "Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002059" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000203" ; oboInOwl:hasDbXref "HP:0002059" ; oboInOwl:hasExactSynonym "Cortical Atrophy", "Degeneration of Cerebrum", "Supratentorial Atrophy" ; a owl:Class ; rdfs:comment "Atrophy may be progressive over time." ; rdfs:label "Cerebral Atrophy" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0002060 obo:IAO_0000115 "An abnormality of the telencephalon, which is also known as the cerebrum." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002060" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008895" ; oboInOwl:hasDbXref "HP:0002060" ; oboInOwl:hasExactSynonym "Abnormal Cerebral Morphology", "Abnormality of the Telencephalon" ; a owl:Class ; rdfs:label "Abnormality of the Cerebrum" ; rdfs:subClassOf obo:HP_0012639 . obo:HP_0002067 obo:IAO_0000115 "Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002067" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000158" ; oboInOwl:hasDbXref "HP:0002067" ; oboInOwl:hasExactSynonym "Slow Movements", "Slowness of Movements" ; a owl:Class ; rdfs:label "Bradykinesia" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0002071 obo:IAO_0000115 "A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless)." ; obo:SCDO_0000340 obo:HP_0002071 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001311" ; oboInOwl:hasDbXref "HP:0002071" ; oboInOwl:hasExactSynonym "Abnormality of Extrapyramidal Motor Function", "Extrapyramidal Dysfunction", "Extrapyramidal Signs", "Extrapyramidal Syndrome", "Extrapyramidal Tract Signs" ; a owl:Class ; rdfs:label "Extrapyramidal Symptoms" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C74954 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001322 ] . obo:HP_0002076 obo:IAO_0000115 "Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms." ; obo:SCDO_0000340 obo:HP_0002076 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000759" ; oboInOwl:hasDbXref "HP:0002076" ; oboInOwl:hasExactSynonym "Intermittent Migraine Headaches", "Migraine Headache" ; a owl:Class ; rdfs:comment "Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an \"aura,\" visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances. Migraine in some women may relate to changes in hormones and hormonal levels during their menstrual cycle. For many years, scientists believed that migraines were linked to the dilation and constriction of blood vessels in the head. Investigators now believe that migraine has a genetic cause." ; rdfs:label "Migraine" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OGMS_0000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000382 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:HP_0002086 obo:IAO_0000115 "An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles." ; obo:SCDO_0000303 "Curation completed by the SCDO curator team: Amy and Khuthala." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002086" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004899" ; oboInOwl:hasDbXref "HP:0002086" ; oboInOwl:hasExactSynonym "Respiratory Abnormality" ; a owl:Class ; rdfs:label "Abnormality of the Respiratory System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0002090 obo:IAO_0000115 "Inflammation of any part of the lung parenchyma." ; obo:SCDO_0000340 obo:HP_0002090 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009838" ; oboInOwl:hasDbXref "HP:0002090" ; a owl:Class ; rdfs:label "Pneumonia" ; rdfs:subClassOf obo:HP_0002086, obo:HP_0002715 . obo:HP_0002098 obo:IAO_0000115 "Difficulty in breathing. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea." ; obo:SCDO_0000303 "Is a symptom of acute chest syndrome" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002098" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009656" ; oboInOwl:hasDbXref "HP:0002098" ; oboInOwl:hasExactSynonym "Breathing Difficulties", "Difficulty Breathing", "Respiratory Difficulties" ; a owl:Class ; rdfs:label "Respiratory Distress" ; rdfs:subClassOf obo:HP_0002086, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0002138 obo:IAO_0000115 "Hemorrhage occurring between the arachnoid mater and the pia mater." ; obo:SCDO_0000340 obo:HP_0002138 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001118" ; oboInOwl:hasDbXref "HP:0002138" ; oboInOwl:hasExactSynonym "Subarachnoid Haemorrhage" ; a owl:Class ; rdfs:comment "Subarachnoid hemorrhage may occur spontaneously, usually from a ruptured cerebral aneurysm, or may result from head injury." ; rdfs:label "Subarachnoid Hemorrhage" ; rdfs:subClassOf obo:HP_0002170, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001159 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0002149 obo:IAO_0000115 "An abnormally high level of uric acid in the blood." ; obo:SCDO_0000340 obo:HP_0002149 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000596" ; oboInOwl:hasDbXref "HP:0002149" ; oboInOwl:hasExactSynonym "High Blood Uric Acid Level", "Hyperuricaemia" ; a owl:Class ; rdfs:label "Hyperuricemia" ; rdfs:subClassOf obo:HP_0002157, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0002157 obo:IAO_0000115 "An increased concentration of nitrogen compounds in the blood." ; obo:SCDO_0000303 "Perhaps move to below \"Endocrine and Metabolic\"? -- -- Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0002157 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000093" ; oboInOwl:hasDbXref "HP:0002157" ; oboInOwl:hasExactSynonym "Azotemia" ; a owl:Class ; rdfs:label "Azotaemia" ; rdfs:subClassOf obo:HP_0004364, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000983 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0002164 obo:IAO_0000115 "The presence of developmental dysplasia of the nail." ; obo:SCDO_0000340 obo:HP_0002164 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000830" ; oboInOwl:hasDbXref "HP:0002164" ; oboInOwl:hasExactSynonym "Dysplastic Nails", "Onychodysplasia" ; a owl:Class ; rdfs:label "Nail Dysplasia" ; rdfs:subClassOf obo:HP_0001574, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0002170 obo:IAO_0000115 "Hemorrhage occurring within the skull." ; obo:SCDO_0000340 obo:HP_0002170 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000654" ; oboInOwl:hasDbXref "HP:0002170" ; a owl:Class ; rdfs:label "Intracranial Hemorrhage" ; rdfs:subClassOf obo:SCDO_1000037, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001327 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001249 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0002181 obo:IAO_0000115 "Abnormal accumulation of fluid in the brain." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002181" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000207" ; oboInOwl:hasDbXref "HP:0002181" ; oboInOwl:hasExactSynonym "Brain Edema", "Brain Oedema", "Cerebral Oedema" ; a owl:Class ; rdfs:label "Cerebral Edema" ; rdfs:subClassOf obo:HP_0000969, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:HP_0002204 obo:IAO_0000115 "An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery." ; obo:SCDO_0000340 obo:HP_0002204 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007912" ; oboInOwl:hasDbXref "HP:0002204" ; oboInOwl:hasExactSynonym "Blood Clot in Artery of Lung" ; a owl:Class ; rdfs:label "Pulmonary Embolism" ; rdfs:subClassOf obo:HP_0030680 . obo:HP_0002240 obo:IAO_0000115 "Abnormally increased size of the liver." ; obo:SCDO_0000340 obo:HP_0002240 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005566" ; oboInOwl:hasDbXref "HP:0002240" ; a owl:Class ; rdfs:label "Hepatomegaly" ; rdfs:subClassOf obo:HP_0001392, obo:NCIT_C115224 . obo:HP_0002341 obo:IAO_0000115 "Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002341" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000214" ; oboInOwl:hasDbXref "HP:0002341" ; oboInOwl:hasExactSynonym "Cervical Cord Compression Myelopathy", "Cervical Spondylotic Myelopathy", "Spinal Cord Compression" ; a owl:Class ; rdfs:label "Cervical Cord Compression" ; rdfs:subClassOf obo:HP_0012639, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000963 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C561 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001249 ] . obo:HP_0002427 obo:IAO_0000115 "Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it." ; obo:SCDO_0000340 obo:HP_0002427 ; obo:SCDO_0000468 "Aphasia is one of the most common communication disorders to affect the brain. Although there are no official figures, the Stroke Association estimates more than 376,000 stroke survivors in the UK are living with aphasia. Aphasia can affect people of all ages, including children. It's most common in people over 65 years old as stroke and common progressive neurological conditions tend to affect older adults" ; obo:SCDO_0000661 "Aphasia is caused by damage to parts of the brain responsible for understanding and using language. Common causes include:stroke, thought to be the most common cause, around one in three people experience some degree of aphasia after having a stroke.severe head injury. brain tumour.progressive neurological conditions (conditions that over time cause progressive brain and nervous system damage)." ; obo:SCDO_0000662 "Experience difficulties with understanding or expressing language." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000773" ; oboInOwl:hasDbXref "HP:0002427" ; oboInOwl:hasExactSynonym "Broca's Aphasia", "Expressive Aphasia", "Loss of Expressive Speech" ; a owl:Class ; rdfs:label "Motor Aphasia" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0002516 obo:IAO_0000115 "An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002516" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000655" ; oboInOwl:hasDbXref "HP:0002516" ; oboInOwl:hasExactSynonym "Increased Intracranial Pressure", "Intracranial Pressure Elevation", "Rise in Pressure Inside Skull" ; a owl:Class ; rdfs:label "Intracranial Hypertension" ; rdfs:subClassOf obo:HP_0000822, obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:HP_0002597 obo:IAO_0000115 "An abnormality of the vasculature." ; obo:SCDO_0000340 obo:HP_0002597 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000373" ; oboInOwl:hasDbXref "HP:0002597" ; a owl:Class ; rdfs:label "Abnormality of the Vasculature" ; rdfs:subClassOf obo:HP_0001626 . obo:HP_0002650 obo:IAO_0000115 "The presence of an abnormal lateral curvature of the spine." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002650" ; obo:SCDO_0000661 "Congenital vertebral anomalies, idiopathic, result of a neuromuscular condition." ; obo:SCDO_0000662 "Spinal tortuosity." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001026" ; oboInOwl:hasDbXref "HP:0002650" ; oboInOwl:hasExactSynonym "Abnormal Curving of the Spine" ; a owl:Class ; rdfs:label "Scoliosis" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0002653 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002653" ; obo:SCDO_0000661 "A number of diseases may cause bone pain including osteoarthritis, Paget's disease, sickle cell anemia, and bone cancer. Acute leukemia;Acute rheumatic fever, a very dangerous disease that can cause permanent cardiac damage. Bursitis;Fibromyalgia like disease has been studied as a cause of joint pain in the child.Hypermobility syndrome can present with knee or ankle pain;Injury such as a fracture. Juvenile rheumatoid arthritis;Lupus;Lyme disease, which is transmitted by ticks and is characterized by debilatating polyarthritis, neurologic symptoms, and erythema migrans.;Osteomyelitis;Osteosarcoma.Septic arthritis, a severe infection of the joint that can lead to permanent joint damage.Synovitis;Viral diseases, including the measles, influenza, mononucleosis, chickenpox, and mumps." ; obo:SCDO_0000662 "Stimulation of specialized pain-sensitive nerve fibers (nociceptors) that innervate bone tissue leads to the sensation of bone pain. Bone pain originates from both the periosteum and the bone marrow which relay nociceptive signals to the brain creating the sensation of pain. Bone tissue is innervated by both myelinated (A beta and A delta fiber) and unmyelinated (C fiber) sensory neurons. In combination, they can provide an initial burst of pain, initiated by the faster myelinated fibers, followed by a slower and longer lasting dull pain initiated by unmyelinated fibers" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000154" ; oboInOwl:hasDbXref "HP:0002653" ; a owl:Class ; rdfs:label "Bone Pain" ; rdfs:subClassOf obo:SCDO_0000851, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0002659 obo:IAO_0000115 "An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002659" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000153" ; oboInOwl:hasDbXref "HP:0002659" ; oboInOwl:hasExactSynonym "Abnormal Susceptibility to Fractures", "Frequent Broken Bones", "Increased Bone Fragility", "Increased Susceptibility to Fractures", "Increased Tendency to Fractures" ; a owl:Class ; rdfs:label "Bone Fragility" ; rdfs:subClassOf obo:HP_0000924 . obo:HP_0002665 obo:IAO_0000115 "A cancer originating in lymphocytes and presenting as a solid tumor of lymphoid cells." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002665" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000707" ; oboInOwl:hasDbXref "HP:0002665" ; oboInOwl:hasExactSynonym "Cancer of Lymphatic System" ; a owl:Class ; rdfs:label "Lymphoma" ; rdfs:subClassOf obo:OBI_1110053, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0002715 obo:IAO_0000115 "An abnormality of the immune system." ; obo:SCDO_0000303 """Include as sub-class: Acquired Immunodeficiency Syndrome (term in NCIT)""" ; obo:SCDO_0000340 obo:HP_0002715 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000273" ; oboInOwl:hasDbXref "HP:0002715" ; a owl:Class ; rdfs:label "Abnormality of the Immune System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0002725 obo:IAO_0000115 "A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002725" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001137" ; oboInOwl:hasDbXref "HP:0002725" ; a owl:Class ; rdfs:label "Systemic Lupus Erythematosus" ; rdfs:subClassOf obo:SCDO_0000267, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000709 ] . obo:HP_0002808 obo:IAO_0000115 "Exaggerated anterior convexity of the thoracic vertebral column." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002808" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000679" ; oboInOwl:hasDbXref "HP:0002808" ; oboInOwl:hasExactSynonym "Gibbus Deformity", "Hunched Back", "Hyperkyphosis", "Round Back" ; a owl:Class ; rdfs:label "Kyphosis" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0002829 obo:IAO_0000115 "Joint pain." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002829" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000074" ; oboInOwl:hasDbXref "HP:0002829" ; oboInOwl:hasExactSynonym "Arthralgias", "Joint pain" ; a owl:Class ; rdfs:label "Arthralgia" ; rdfs:subClassOf obo:SCDO_0000851, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:HP_0002870 obo:IAO_0000115 "A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002870" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000820" ; oboInOwl:hasDbXref "HP:0002870" ; oboInOwl:hasExactSynonym "Obstructive Sleep Apnoea" ; a owl:Class ; rdfs:label "Obstructive Sleep Apnea" ; rdfs:subClassOf obo:HP_0000708, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000417 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000420 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000945 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000689 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0002907 obo:IAO_0000115 "Microscopic hematuria detected by dipstick or microscopic examination of the urine." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002907" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004833" ; oboInOwl:hasDbXref "HP:0002907" ; oboInOwl:hasExactSynonym "Microhematuria", "Occult Hematuria", "Small Amount of Blood in Urine" ; a owl:Class ; rdfs:label "Microscopic Hematuria" ; rdfs:subClassOf obo:SCDO_0000508, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0002913 obo:IAO_0000115 "Presence of myoglobin in the urine." ; obo:SCDO_0000340 obo:HP_0002913 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000783" ; oboInOwl:hasDbXref "HP:0002913" ; oboInOwl:hasExactSynonym "Increased Urine Myoglobin Level" ; a owl:Class ; rdfs:label "Myoglobinuria" ; rdfs:subClassOf obo:HP_0000079, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000983 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ] . obo:HP_0002955 obo:IAO_0000115 "Any disease characterized by the formation of numerous granulomas." ; obo:SCDO_0000303 "Source needed for additional information." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002955" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000464" ; oboInOwl:hasDbXref "HP:0002955" ; a owl:Class ; rdfs:comment """Has disease stages: Allergic (Churg-strauss syndrome), eosinophilic (langerhan cell histiocytosis), langerhans (langerhan cell histiocytosis), lymphomatoid, siderotica, wegeners. Is caused by: Genetic predispositions, autoimmune mediated, chronic inflammation.""" ; rdfs:label "Granulomatosis" ; rdfs:subClassOf obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0003077 obo:IAO_0000115 "An elevated lipid concentration in the blood." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0003077" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000590" ; oboInOwl:hasDbXref "HP:0003077" ; oboInOwl:hasExactSynonym "Elevated Lipids in Blood" ; a owl:Class ; rdfs:label "Hyperlipidemia" ; rdfs:subClassOf obo:HP_0003611 . obo:HP_0003110 obo:IAO_0000115 "An abnormality of the composition of urine or the levels of its components." ; obo:SCDO_0000340 obo:HP_0003110 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000651" ; oboInOwl:hasDbXref "HP:0003110" ; oboInOwl:hasExactSynonym "Abnormal Urine Chemistry", "Abnormality of Urine Homeostasis" ; a owl:Class ; rdfs:label "Abnormal Urine Homeostasis" ; rdfs:subClassOf obo:HP_0000079, obo:SCDO_0002674 . obo:HP_0003116 obo:IAO_0000115 "An abnormality detectable by sonography of the heart (echocardiography)." ; obo:SCDO_0000340 obo:HP_0003116 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000267" ; oboInOwl:hasDbXref "HP:0003116" ; oboInOwl:hasExactSynonym "Abnormal ECG", "Abnormal Echocardiography" ; a owl:Class ; rdfs:label "Abnormal Echocardiogram" ; rdfs:subClassOf obo:HP_0500015 . obo:HP_0003126 obo:IAO_0000115 "Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0003126" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001196" ; oboInOwl:hasDbXref "HP:0003126" ; oboInOwl:hasExactSynonym "Low-Molecular-Weight Proteinuria" ; a owl:Class ; rdfs:label "Tubular Proteinuria" ; rdfs:subClassOf obo:SCDO_0000932, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000055 ] . obo:HP_0003155 obo:IAO_0000115 "Abnormally increased serum levels of alkaline phosphatase activity." ; obo:SCDO_0000340 obo:HP_0003155 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000664" ; oboInOwl:hasDbXref "HP:0003155" ; oboInOwl:hasExactSynonym "Blood Alkaline Phosphatase Increased", "Decreased Circulating Alkaline Phosphatase Level", "Elevated ALP", "Elevated Alkaline Phosphatase", "High Serum Alkaline Phosphatase", "Increased Alkaline Phosphatase", "Reduced Circulating ALP" ; a owl:Class ; rdfs:label "Elevated Serum Alkaline Phosphatase" ; rdfs:subClassOf obo:HP_0004379 . obo:HP_0003158 obo:IAO_0000115 "An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine." ; obo:SCDO_0000303 "Could this be a synonym for 'Impaired Urinary Concentration' (SCDO:0000621)?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0003158" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008046" ; oboInOwl:hasDbXref "HP:0003158" ; a owl:Class ; rdfs:comment "Urine specific gravity is lower than that of plasma < 1.008." ; rdfs:label "Hyposthenuria" ; rdfs:subClassOf obo:HP_0004727, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:HP_0003198 obo:IAO_0000115 "A disorder of muscle unrelated to impairment of innervation or neuromuscular junction." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0003198" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000784" ; oboInOwl:hasDbXref "HP:0003198" ; oboInOwl:hasExactSynonym "Muscle Tissue Disease", "Myopathic Changes", "Myopathies" ; a owl:Class ; rdfs:label "Myopathy" ; rdfs:subClassOf obo:SCDO_1000268, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0003265 obo:IAO_0000115 "A type of hyperbilirubinemia with neonatal onset." ; obo:SCDO_0000340 obo:HP_0003265 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003776" ; oboInOwl:hasDbXref "HP:0003265" ; oboInOwl:hasExactSynonym "High Blood Bilirubin Levels in Neonate" ; a owl:Class ; rdfs:label "Neonatal Hyperbilirubinemia" ; rdfs:subClassOf obo:NCIT_C27088 . obo:HP_0003282 obo:IAO_0000115 "Abnormally reduced serum levels of alkaline phosphatase." ; obo:SCDO_0000340 obo:HP_0003282 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000667" ; oboInOwl:hasDbXref "HP:0003282" ; oboInOwl:hasExactSynonym "Low ALP", "Low Alkaline Phosphatase", "Reduced Serum Alkaline Phosphatase" ; a owl:Class ; rdfs:label "Decreased Serum Alkaline Phosphatase" ; rdfs:subClassOf obo:HP_0004379 . obo:HP_0003302 obo:IAO_0000115 "Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0003302" ; obo:SCDO_0000661 "Spondylolysis, arthritis, degeneration, trauma, metastases or metabolic bone disease, congenital." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001102" ; oboInOwl:hasDbXref "HP:0003302" ; oboInOwl:hasExactSynonym "Displacement of One Backbone Compared to Another", "Slipped Backbone", "Spondylolithesis" ; a owl:Class ; rdfs:label "Spondylolisthesis" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0003394 obo:IAO_0000115 "Sudden and involuntary contractions of one or more muscles." ; obo:SCDO_0000340 obo:HP_0003394 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000778" ; oboInOwl:hasDbXref "HP:0003394" ; oboInOwl:hasExactSynonym "Muscle Spasm" ; a owl:Class ; rdfs:label "Muscle Cramps" ; rdfs:subClassOf obo:SCDO_1000268, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0003418 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0003418 ; obo:SCDO_0000661 "muscle strain, trauma, surgery, fracture, osteoporosis, fibromialgia, spinal disc herniation." ; obo:SCDO_0000662 "Pain in the lower back." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000095" ; oboInOwl:hasDbXref "HP:0003418" ; a owl:Class ; rdfs:label "Back Pain" ; rdfs:subClassOf obo:SCDO_0000851, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0003457 obo:IAO_0000115 "Abnormal results of investigations using electromyography (EMG)." ; obo:SCDO_0000340 obo:HP_0003457 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000428" ; oboInOwl:hasDbXref "HP:0003457" ; oboInOwl:hasExactSynonym "Abnormal EMG", "Abnormal Electromyography (EMG).", "Abnormal Electromyography Finding", "EMG Abnormalities", "Electromyogram Abnormal" ; a owl:Class ; rdfs:label "EMG Abnormality" ; rdfs:subClassOf obo:SCDO_1000268 . obo:HP_0003470 obo:IAO_0000115 "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Motor paralysis is often accompanied by an impairment in the facility of movement." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0003470" ; obo:SCDO_0000661 "Most paralysis is due to strokes or injuries such as spinal cord injury or a broken neck. Other causes of paralysis include: Nerve diseases such as amyotrophic lateral sclerosis, Autoimmune diseases such as Guillain-Barre syndrome, Bell's palsy, which affects muscles in the face, Polio used to be a cause of paralysis, but polio no longer occurs in the U.S." ; obo:SCDO_0000662 "Paralysis can be complete or partial. It can occur on one or both sides of your body. It can also occur in just one area, or it can be widespread. Paralysis of the lower half of your body, including both legs, is called paraplegia. Paralysis of the arms and legs is quadriplegia." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000865" ; oboInOwl:hasDbXref "HP:0003470" ; oboInOwl:hasExactSynonym "Inability to Move" ; a owl:Class ; rdfs:label "Paralysis" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0003563 obo:IAO_0000115 "Reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions." ; obo:SCDO_0000340 obo:MP_0000183 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000703" ; oboInOwl:hasDbXref "HP:0003563" ; oboInOwl:hasExactSynonym "Decreased Circulating Low-Density Lipoprotein Levels", "Decreased LDL", "Decreased LDL Cholesterol Concentration", "Decreased LDL Cholesterol Level", "Decreased LDLc Concentration", "Low Circulating LDL Cholesterol Level", "Low LDL-Cholestrol Levels", "Reduced Circulating LDL Cholesterol Level" ; a owl:Class ; rdfs:label "Decreased Circulating LDL Cholesterol Level" ; rdfs:subClassOf obo:HP_0003611 . obo:HP_0003573 obo:IAO_0000115 "Increased concentration of total (conjugated and unconjugated) bilirubin in the blood." ; obo:SCDO_0000340 obo:HP_0003573 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000681" ; oboInOwl:hasDbXref "HP:0003573" ; oboInOwl:hasExactSynonym "High Bili Total", "High Total Bilirubin", "Increased Bilirubin" ; a owl:Class ; rdfs:label "Increased Total Bilirubin" ; rdfs:subClassOf obo:NCIT_C27088 . obo:HP_0003611 obo:IAO_0000115 "Anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MP_0003949" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000404" ; oboInOwl:hasDbXref "HP:0003611" ; oboInOwl:hasExactSynonym "Abnormal Circulating Lipid Concentration", "Abnormal Circulating Lipid Level", "Dyslipidaemia" ; a owl:Class ; rdfs:label "Dyslipidemia" ; rdfs:subClassOf obo:MP_0002118, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000498 ] . obo:HP_0003641 obo:IAO_0000115 "The presence of free hemoglobin in the urine." ; obo:SCDO_0000340 obo:HP_0003641 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000554" ; oboInOwl:hasDbXref "HP:0003641" ; oboInOwl:hasExactSynonym "Increased Urine Hemoglobin Level" ; a owl:Class ; rdfs:comment "If, following hemolysis, haptoglobins (hemoglobin-binding proteins) are saturated, then free hemoglobin appears in the urine." ; rdfs:label "Hemoglobinuria" ; rdfs:subClassOf obo:HP_0000077, obo:SCDO_1000383, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0003765 obo:IAO_0000115 "A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales)." ; obo:SCDO_0000340 obo:HP_0003765 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000936" ; oboInOwl:hasDbXref "HP:0003765" ; oboInOwl:hasExactSynonym "Psoriasiform Dermatitis" ; a owl:Class ; rdfs:label "Psoriasis" ; rdfs:subClassOf obo:HP_0011122 . obo:HP_0003774 obo:IAO_0000115 "A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine, greater than 3 months." ; obo:SCDO_0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0003774 ; obo:SCDO_0000468 "Variable" ; obo:SCDO_0000661 "Final outcome of any form of kidney disease ; may be caused by diabetes, hypertension, glomerular disease, polycystic kidney disease, sickle cell disease, chronic toxic injury." ; obo:SCDO_0000662 "Elevated serum creatinine, uremia, acidosis, hyperkalemia, hyperphosphatemia, secondary hyperpararthyroidism, anemia, hypertension, fluid retention." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000430" ; oboInOwl:hasDbXref "HP:0003774" ; oboInOwl:hasExactSynonym "ESKD", "ESRD", "End Stage Renal Disease", "End Stage Renal Disease (ESRD)", "End Stage Renal Failure", "End-Stage Renal Disease", "End-Stage Renal Failure", "Stage 5 Chronic Kidney Disease" ; a owl:Class ; rdfs:label "End Stage Kidney Disease" ; rdfs:subClassOf obo:SCDO_0000226, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000983 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000985 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000219 ; owl:someValuesFrom obo:SCDO_0000588 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0004312 obo:IAO_0000115 "A reticulocyte abnormality." ; obo:SCDO_0000340 obo:HP_0004312 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000265" ; oboInOwl:hasDbXref "HP:0004312" ; a owl:Class ; rdfs:label "Abnormality of Reticulocytes" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0004364 obo:IAO_0000115 "Any deviation from the normal concentration of a nitrogen compound in the blood circulation." ; obo:SCDO_0000340 obo:HP_0004364 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000647" ; oboInOwl:hasDbXref "HP:0004364" ; a owl:Class ; rdfs:label "Abnormal Circulating Nitrogen Compound Concentration" ; rdfs:subClassOf obo:HP_0032180 . obo:HP_0004379 obo:IAO_0000115 "An abnormality of alkaline phosphatase level." ; obo:SCDO_0000340 obo:HP_0004379 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000666" ; oboInOwl:hasDbXref "HP:0004379" ; oboInOwl:hasExactSynonym "Abnormality Alkaline Phosphatase Level", "Abnormality of ALP Level", "Abnormality of Alkaline Phosphatase Activity", "Alkaline Phosphatase Abnormal" ; a owl:Class ; rdfs:comment "Note that the alkaline phosphatase family has four isoenzymes in humans, each of which additionally can have different isoforms. The primary clinical importance of measuring alkaline phosphatase is to check the possibility of bone disease or liver disease." ; rdfs:label "Abnormality of Alkaline Phosphatase Level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0004447 obo:IAO_0000115 "The presence of abnormally shaped erythrocytes." ; obo:SCDO_0000340 obo:HP_0004447 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000245" ; oboInOwl:hasDbXref "HP:0004447" ; a owl:Class ; rdfs:label "Poikilocytosis" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0004586 obo:IAO_0000115 "Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward." ; obo:SCDO_0000340 obo:HP_0004586 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000118" ; oboInOwl:hasDbXref "HP:0004586" ; oboInOwl:hasExactSynonym "Biconcave Vertebrae", "Fish Mouth Deformity", "Fish Vertebrae", "Step Vertebrae" ; a owl:Class ; rdfs:label "Biconcave Vertebral Bodies" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ] . obo:HP_0004727 obo:IAO_0000115 "A defect in the ability to concentrate the urine." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0004727" ; obo:SCDO_0000468 "Notable within the first decade of life." ; obo:SCDO_0000661 "Can be caused by tubular damage in the kidney; can be seen in sickle cell disease and sickle cell trait." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000621" ; oboInOwl:hasDbXref "HP:0004727" ; oboInOwl:hasExactSynonym "UCD", "Urine Concentrating Defect", "Urine Concentration Defect" ; a owl:Class ; rdfs:label "Impaired Renal Concentrating Ability" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ] . obo:HP_0004756 obo:IAO_0000115 "A tachycardia originating in the ventricles characterized by rapid heart rate (over 100 beats per minute) and broad QRS complexes (over 120 ms)." ; obo:SCDO_0000340 obo:HP_0004756 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003769" ; dc:source obo:HP_0004756 ; oboInOwl:hasDbXref "HP:0004756" ; oboInOwl:hasExactSynonym "VT" ; a owl:Class ; rdfs:comment "Ventricular tachycardia (VT) is a potentially life-threatening ventricular arrhythmia that presents as a wide QRS complex tachycardia, and is defined as three or more consecutive QRS complexes with a duration longer than 120 milliseconds (ms) and a rate of 100 beats per minute or more, whereby the complexes have a ventricular origin. VT can be subdivided as follows: (i) sustained VT persists for 30 seconds or more; (ii) non-sustained VT lasts less than 30 seconds; (iii) monomorphic VT displays a uniform QRS morphology; and (iv) polymorphic VT displays QRS morphologies that variy from beat to beat. VT is observed most commonly in individuals with structural heart disease or acute myocardial infarction (MI). VT may also be observed in in the setting of drug toxicity or electrolyte abnormalities or in individuals with Mendelian disease." ; rdfs:label "Ventricular Tachycardia" ; rdfs:subClassOf obo:SCDO_0001851 . obo:HP_0004825 obo:IAO_0000115 "An abnormal increase in the binding affinity of hemoglobin for oxygen." ; obo:SCDO_0000340 obo:HP_0004825 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000248" ; oboInOwl:hasDbXref "HP:0004825" ; oboInOwl:hasExactSynonym "Increased Haemoglobin Oxygen Affinity" ; a owl:Class ; rdfs:label "Increased Hemoglobin Oxygen Affinity" ; rdfs:subClassOf obo:HP_0020054 . obo:HP_0004870 obo:IAO_0000115 "A chronic form of hemolytic anemia." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0004870" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001248" ; oboInOwl:hasDbXref "HP:0004870" ; a owl:Class ; rdfs:label "Chronic Hemolytic Anemia" ; rdfs:subClassOf obo:HP_0001878, obo:SCDO_0005167, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:HP_0005162 obo:IAO_0000115 "Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0005162" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002710" ; oboInOwl:hasDbXref "HP:0005162" ; oboInOwl:hasExactSynonym "Impaired Left Ventricular Function", "Left Ventricular Failure", "Left Ventricular Impairment", "Left-Sided Heart Failure" ; a owl:Class ; rdfs:label "Left Ventricular Dysfunction" ; rdfs:subClassOf obo:HP_0011025, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0005268 obo:IAO_0000115 "A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 20th week of pregnancy." ; obo:SCDO_0000340 obo:HP_0005268 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001103" ; oboInOwl:hasDbXref "HP:0005268" ; oboInOwl:hasExactSynonym "Miscarriage" ; a owl:Class ; rdfs:label "Spontaneous Abortion" ; rdfs:subClassOf obo:HP_0001787, obo:NCIT_C34941, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0005305 obo:IAO_0000115 "Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow." ; obo:SCDO_0000303 "Add \"Cerebral Venous Sinus Thrombosis\" (in the Stroke Ontology) as a sub-class" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0005305" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000211" ; oboInOwl:hasDbXref "HP:0005305" ; oboInOwl:hasExactSynonym "Blood Clot in Cerebral Vein", "Cerebral Thrombosis", "Cerebral Vein Thrombosis" ; a owl:Class ; rdfs:label "Cerebral Venous Thrombosis" ; rdfs:subClassOf obo:HP_0001977, obo:HP_0002060, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001327 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0005318 obo:IAO_0000115 "Inflammation of the blood vessels within the brain." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0005318" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000210" ; oboInOwl:hasDbXref "HP:0005318" ; a owl:Class ; rdfs:label "Cerebral Vasculitis" ; rdfs:subClassOf obo:HP_0002060, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000219 ; owl:someValuesFrom obo:HP_0012229 ] . obo:HP_0005518 obo:IAO_0000115 "Larger than normal size of erythrocytes. Macrocytosis refers to a mean cell volume (MCV) greater than 100 fL. If macrocytosis is an isolated abnormality, the amount of hemoglobin in the cell increases proportionately, so the mean cell hemoglobin concentration (MCHC) remains within normal limits." ; obo:SCDO_0000340 obo:HP_0005518 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000626" ; oboInOwl:hasDbXref "HP:0005518" ; oboInOwl:hasExactSynonym "Erythrocyte Macrocytosis", "High MCV", "Increased MCV" ; a owl:Class ; rdfs:label "Increased Mean Corpuscular Volume" ; rdfs:subClassOf obo:HP_0025065 . obo:HP_0005560 obo:IAO_0000115 "Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0005560" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001383" ; oboInOwl:hasDbXref "HP:0005560" ; a owl:Class ; rdfs:label "Imbalanced Hemoglobin Synthesis" ; rdfs:subClassOf obo:HP_0001877, obo:SCDO_1000060, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000251 ] . obo:HP_0006689 obo:IAO_0000115 "A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves." ; obo:SCDO_0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000099" ; dc:source obo:HP_0006689 ; oboInOwl:hasDbXref "HP:0006689" ; oboInOwl:hasExactSynonym "Infective Endocarditis" ; a owl:Class ; rdfs:label "Bacterial Endocarditis" ; rdfs:subClassOf obo:NCIT_C2890, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:IDO_0000560 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ] . obo:HP_0007018 obo:IAO_0000115 "Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0007018" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000090" ; oboInOwl:hasDbXref "HP:0007018" ; oboInOwl:hasExactSynonym "ADHD", "Attention Deficit", "Attention Deficit Disorder", "Attention Deficit-Hyperactivity Disorder", "Attention Deficits", "Childhood Attention Deficit/Hyperactivity Disorder" ; a owl:Class ; rdfs:label "Attention Deficit Hyperactivity Disorder" ; rdfs:subClassOf obo:HP_0000708 . obo:HP_0007340 obo:IAO_0000115 "Weakness of the muscles of the legs." ; obo:SCDO_0000340 obo:HP_0007340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000686" ; oboInOwl:hasDbXref "HP:0007340" ; oboInOwl:hasExactSynonym "Hind Limb Weakness", "Hindlimb Weakness", "Leg Weakness", "Lower Extremity Weakness", "Lower Limb Muscle Weakness", "Lower Limb Weakness", "Muscle Weakness in Lower Limbs" ; a owl:Class ; rdfs:comment "Inability to perform rapid, alternating movements." ; rdfs:label "Leg Weakness" ; rdfs:subClassOf obo:HP_0025142, obo:SCDO_1000268, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0007902 obo:IAO_0000115 "Bleeding within the vitreous compartment of the eye." ; obo:SCDO_0000340 obo:HP_0007902 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001238" ; oboInOwl:hasDbXref "HP:0007902" ; oboInOwl:hasExactSynonym "Hemorrage Within the Vitreous Humor", "Vitreous Haemorrhage" ; a owl:Class ; rdfs:label "Vitreous Hemorrhage" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001237 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0008245 obo:IAO_0000115 "A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0008245" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001028" ; oboInOwl:hasDbXref "HP:0008245" ; oboInOwl:hasExactSynonym "TSH Deficient Hypothyroidism", "Thyroid Stimulating Hormone Deficiency", "Thyrotropin Deficiency" ; a owl:Class ; rdfs:label "Secondary Hypothyroidism" ; rdfs:subClassOf obo:HP_0000821 . obo:HP_0008404 obo:IAO_0000115 "Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate." ; obo:SCDO_0000340 obo:HP_0008404 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000788" ; oboInOwl:hasDbXref "HP:0008404" ; oboInOwl:hasExactSynonym "Dystrophic Nails", "Onychodystrophy", "Poor nail formation" ; a owl:Class ; rdfs:label "Nail Dystrophy" ; rdfs:subClassOf obo:HP_0001574, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:IDO_0000560 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ] . obo:HP_0008682 obo:IAO_0000115 "Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0008682 ; obo:SCDO_0000468 "Can occur at any age." ; obo:SCDO_0000472 "The clinical course of acute tubular necrosis may be divided into initiation, maintenance, and recovery phases." ; obo:SCDO_0000661 "Renal ischemia (which can occur due to prolonged prerenal states), nephrotoxins, or sepsis. In sickle cell disease, may occur due to renal ischemia related to sickle crisis." ; obo:SCDO_0000662 "Loss of kidney function, reduced urine output, elevated serum creatinine." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000020" ; oboInOwl:hasDbXref "HP:0008682" ; oboInOwl:hasExactSynonym "ATN", "Renal Tubular Necrosis" ; a owl:Class ; rdfs:label "Acute Tubular Necrosis" ; rdfs:subClassOf obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000983 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ] . obo:HP_0009045 obo:IAO_0000115 "Rhabdomyolysis induced by exercise." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0009045" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001308" ; oboInOwl:hasDbXref "HP:0009045" ; oboInOwl:hasExactSynonym "Rhabdomyolysis with Exercise" ; a owl:Class ; rdfs:label "Exercise-Induced Rhabdomyolysis" ; rdfs:subClassOf obo:SCDO_1000260, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000004 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000199 ; owl:someValuesFrom obo:NCIT_C16567 ] . obo:HP_0009830 obo:IAO_0000115 "Peripheral neuropathy is a general term for any disorder of the peripheral nervous system." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0009830" ; obo:SCDO_0000662 "Symptoms depend on which nerve is damaged, and whether the damage affects one nerve, several nerves, or the whole body. Pain and numbness: Tingling or burning in the arms and legs may be an early sign of nerve damage. These feelings often start in your toes and feet. You may have deep pain. This often happens in the feet and legs. You may lose feeling in your legs and arms. Because of this, you may not notice when you step on something sharp. You may not notice when you touch something that is too hot or cold, like the water in a bathtub. You may not know when you have a small blister or sore on your feet. Numbness may make it harder to tell where your feet are moving and can cause a loss of balance. Muscle problems: Damage to the nerves can make it harder to control muscles. It can also cause weakness. You may notice problems moving a part of your body. You may fall because your legs buckle. You may trip over your toes. Doing tasks such as buttoning a shirt may be harder. You may also notice that your muscles twitch or cramp. Your muscles may become smaller. Problems with body organs: People with nerve damage may have problems digesting food. You may feel full or bloated and have heartburn after eating only a little food. Sometimes you may vomit food that has not been digested well. You may have either loose stools or hard stools. Some people have problems swallowing. Damage to the nerves to your heart may cause you to feel light-headed, or faint, when you stand up. Angina is the warning chest pain for heart disease and heart attack. Nerve damage may \"hide\" this warning sign. You should learn other warning signs of a heart attack. They are sudden fatigue, sweating, shortness of breath, nausea, and vomiting." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000884" ; dc:source ; oboInOwl:hasDbXref "HP:0009830" ; oboInOwl:hasExactSynonym "Peripheral Nerve Damage", "Peripheral Neuritis" ; a owl:Class ; rdfs:label "Peripheral Neuropathy" ; rdfs:subClassOf obo:HP_0012639, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OGMS_0000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000250 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000382 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0010628 obo:IAO_0000115 "Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form." ; obo:SCDO_0000303 "- Provide source for additional info." ; obo:SCDO_0000340 obo:HP_0010628 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001315" ; oboInOwl:hasDbXref "HP:0010628" ; oboInOwl:hasExactSynonym "Bell's Palsy", "Cranial Nerve VII Palsy", "Facial Muscle Weakness of Muscles Innervated by CN VII", "Facial Nerve Paralysis", "Facial Palsy", "Facial Paralysis", "Seventh Cranial Nerve Palsy", "VIIth Cranial Nerve Palsy" ; a owl:Class ; rdfs:label "Facial Nerve Palsy" ; rdfs:subClassOf obo:HP_0000271, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OGMS_0000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000822 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000219 ; owl:someValuesFrom obo:HP_0001250 ] . obo:HP_0010876 obo:IAO_0000115 "An abnormal level of a circulating protein in the blood." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000438" ; oboInOwl:hasDbXref "HP:0010876" ; oboInOwl:hasExactSynonym "Abnormality of Circulating Protein Level", "Blood Protein Disease", "Serum Protein Abnormality" ; a owl:Class ; rdfs:label "Abnormal Circulating Protein Level" ; rdfs:subClassOf obo:HP_0032180 . obo:HP_0010885 obo:IAO_0000115 "A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply." ; obo:SCDO_0000303 "No one is sure what causes the disease. Risk factors include: -- -- Long-term steroid treatment -- Alcohol abuse -- Joint injuries -- Having certain diseases, including arthritis and cancer -- Doctors use imaging tests and other tests to diagnose osteonecrosis. -- -- Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery." ; obo:SCDO_0000340 obo:HP_0010885 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000841" ; dc:source obo:HP_0010885, "http://purl.bioontology.org/ontology/MEDLINEPLUS/C0029445" ; oboInOwl:hasDbXref "HP:0010885" ; oboInOwl:hasExactSynonym "AVN", "Aseptic Bone Necrosis", "Aseptic necrosis", "Avascular Bone Necrosis", "Avascular Necrosis", "Avascular Necrosis (AVN)", "Bone Infarction", "Bone Infarcts", "Bone Necrosis", "Ischemic Bone Necrosis", "Osteochondronecrosis" ; a owl:Class ; rdfs:comment "The interruption of the blood supply may have many different causes such as rapid growth, heredity causes, trauma or overuse, anatomic conformation, dietary imbalances or secondary effects of other diseases." ; rdfs:label "Osteonecrosis" ; rdfs:subClassOf obo:HP_0000924, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0008623 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0011001 obo:IAO_0000115 "An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often refered to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011001" ; obo:SCDO_0000661 "Ischemia, chronic infection, and tumor formation, osteoarthritis, osteoma, hepatitis C, . May be caused by faulty bone resorption as a result of some abnormality involving osteoclasts." ; obo:SCDO_0000662 "An increased whiteness (density) of affected bones." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000629" ; oboInOwl:hasDbXref "HP:0011001" ; oboInOwl:hasExactSynonym "Bone Sclerosis", "Increased Bone Density", "Osteosclerosis", "Osteosclerosis of Bones" ; a owl:Class ; rdfs:label "Increased Bone Mineral Density" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0011007 obo:IAO_0000115 "The age group in which disease manifestations appear." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011007" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003913" ; oboInOwl:hasDbXref "HP:0011007" ; a owl:Class ; rdfs:label "Age of Onset" ; rdfs:subClassOf obo:NCIT_C43646 . obo:HP_0011014 obo:IAO_0000115 "Abnormality of glucose homeostasis." ; obo:SCDO_0000340 obo:HP_0011014 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000283" ; oboInOwl:hasDbXref "HP:0011014" ; a owl:Class ; rdfs:label "Abnormal Glucose Homeostasis" ; rdfs:subClassOf obo:SCDO_0002674 . obo:HP_0011025 obo:IAO_0000115 "Abnormal functionality of the cardiovascular system." ; obo:SCDO_0000340 obo:HP_0011025 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000368" ; oboInOwl:hasDbXref "HP:0011025" ; a owl:Class ; rdfs:label "Abnormal Cardiovascular System Physiology" ; rdfs:subClassOf obo:HP_0001626 . obo:HP_0011106 obo:IAO_0000115 "A decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood." ; obo:SCDO_0000340 obo:HP_0011106 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003035" ; oboInOwl:hasDbXref "HP:0011106" ; oboInOwl:hasExactSynonym "Depleted Blood Volume" ; a owl:Class ; rdfs:label "Hypovolemia" ; rdfs:subClassOf obo:HP_0011025 . obo:HP_0011121 obo:IAO_0000115 "Any morphological abnormality of the skin." ; obo:SCDO_0000340 obo:HP_0011121 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000374" ; oboInOwl:hasDbXref "HP:0011121" ; a owl:Class ; rdfs:label "Abnormality of Skin Morphology" ; rdfs:subClassOf obo:HP_0000951 . obo:HP_0011122 obo:IAO_0000115 "Any abnormality of the physiological function of the skin." ; obo:SCDO_0000340 obo:HP_0011122 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000375" ; oboInOwl:hasDbXref "HP:0011122" ; a owl:Class ; rdfs:label "Abnormality of Skin Physiology" ; rdfs:subClassOf obo:HP_0000951 . obo:HP_0011123 obo:IAO_0000115 "The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes." ; obo:SCDO_0000340 obo:HP_0011123 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001071" ; oboInOwl:hasDbXref "HP:0011123" ; oboInOwl:hasExactSynonym "Abnormal Tendency to Infections of the Skin", "Dermatitis", "Inflammatory Abnormality of the Skin", "Inflammatory Skin Disease", "Maculopapular Rash" ; a owl:Class ; rdfs:label "Skin Inflammation" ; rdfs:subClassOf obo:HP_0011122 . obo:HP_0011410 obo:IAO_0000115 "Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011410" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000168" ; oboInOwl:hasDbXref "HP:0011410" ; a owl:Class ; rdfs:label "Caesarian Section" ; rdfs:subClassOf obo:HP_0001787, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0011413 obo:IAO_0000115 "Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex." ; obo:SCDO_0000340 obo:HP_0011413 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001045" ; oboInOwl:hasDbXref "HP:0011413" ; a owl:Class ; rdfs:label "Shoulder Dystocia" ; rdfs:subClassOf obo:HP_0001787 . obo:HP_0011675 obo:IAO_0000115 "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011675" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009619" ; oboInOwl:hasDbXref "HP:0011675" ; oboInOwl:hasExactSynonym "Abnormal Heart Rate", "Abnormality of Cardiac Conduction", "Arrhythmias", "Cardiac Arrhythmia", "Cardiac Arrhythmias", "Cardiac Conduction Abnormalities", "Cardiac Conduction Defects", "Cardiac Rhythm Disturbances", "Heart Rhythm Disorders", "Irregular Heart Beat", "Irregular Heartbeat" ; a owl:Class ; rdfs:label "Arrhythmia" ; rdfs:subClassOf obo:HP_0011025, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0011695 obo:IAO_0000115 "Hemorrhage into the parenchyma of the cerebellum." ; obo:SCDO_0000303 "Need to include this term mentioned here to the SCDO: -- obstructive hydrocephalus" ; obo:SCDO_0000340 obo:HP_0011695 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000201" ; oboInOwl:hasDbXref "HP:0011695" ; a owl:Class ; rdfs:label "Cerebellar Hemorrhage" ; rdfs:subClassOf obo:HP_0002170 . obo:HP_0011856 obo:IAO_0000115 "An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011856" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000904" ; oboInOwl:hasDbXref "HP:0011856" ; a owl:Class ; rdfs:label "Pica" ; rdfs:subClassOf obo:HP_0000708, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0011868 obo:IAO_0000115 "Pain in the lower back and hip radiating in the distribution of the sciatic nerve." ; obo:SCDO_0000303 """Provide source for additional info. Terms to add to therapeutics for linking via \"is treated with\" obj property: Local heat, acupuncture, physical therapy, surgery""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011868" ; obo:SCDO_0000661 "Compression of a spinal nerve root by disc or arthritic spur, degenerative changes involvind main structures, disc protrusion, congenital abnormalities of the bony spinal column, infection, inflammation, neoplasm, vascular diseases." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001024" ; oboInOwl:hasDbXref "HP:0011868" ; a owl:Class ; rdfs:label "Sciatica" ; rdfs:subClassOf obo:HP_0003418, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0011873 obo:IAO_0000115 "Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood." ; obo:SCDO_0000340 obo:HP_0011873 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000617" ; oboInOwl:hasDbXref "HP:0011873" ; a owl:Class ; rdfs:label "Abnormal Platelet Count" ; rdfs:subClassOf obo:HP_0001872 . obo:HP_0011886 obo:IAO_0000115 "Bleeding in the anterior chamber of the eye." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011886" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000597" ; oboInOwl:hasDbXref "HP:0011886" ; a owl:Class ; rdfs:label "Hyphema" ; rdfs:subClassOf obo:HP_0000478, obo:HP_0011025, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0011893 obo:IAO_0000115 "Number of leukocytes per volume of blood beyond normal limits." ; obo:SCDO_0000340 obo:HP_0011893 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000613" ; oboInOwl:hasDbXref "HP:0011893" ; oboInOwl:hasExactSynonym "Abnormal White Blood Cell Count" ; a owl:Class ; rdfs:label "Abnormal Leukocyte Count" ; rdfs:subClassOf obo:SCDO_1000612 . obo:HP_0011897 obo:IAO_0000115 "Increased number of neutrophils circulating in blood." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000447" ; oboInOwl:hasDbXref "HP:0011897" ; a owl:Class ; rdfs:label "Neutrophilia" ; rdfs:subClassOf obo:HP_0011991 . obo:HP_0011904 obo:IAO_0000115 "Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobiin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011904" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000888" ; oboInOwl:hasDbXref "HP:0011904" ; oboInOwl:hasExactSynonym "Increased Haemoglobin F", "Persistence of Hemoglobin F", "Raised Hemoglobin F" ; a owl:Class ; rdfs:label "Increased Hemoglobin F" ; rdfs:subClassOf obo:HP_0020063, obo:SCDO_1000061, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000251 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ] . obo:HP_0011906 obo:IAO_0000115 "A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011906" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001709" ; oboInOwl:hasDbXref "HP:0011906" ; oboInOwl:hasExactSynonym "Increased Alpha/Beta Synthesis Ratio" ; a owl:Class ; rdfs:label "Reduced Beta/Alpha Synthesis Ratio" ; rdfs:subClassOf obo:HP_0005560, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0009731 ] . obo:HP_0011907 obo:IAO_0000115 "A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011907" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006404" ; oboInOwl:hasDbXref "HP:0011907" ; oboInOwl:hasExactSynonym "Increased Beta/Alpha Synthesis Ratio" ; a owl:Class ; rdfs:label "Reduced Alpha/Beta Synthesis Ratio" ; rdfs:subClassOf obo:HP_0005560, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001386 ] . obo:HP_0011950 obo:IAO_0000115 "Inflammation of the bronchioles." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011950" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005490" ; oboInOwl:hasDbXref "HP:0011950" ; a owl:Class ; rdfs:label "Bronchiolitis" ; rdfs:subClassOf obo:HP_0002086, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0011991 obo:IAO_0000115 "A deviation from the normal range of neutrophil cell counts in the circulation." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000446" ; oboInOwl:hasDbXref "HP:0011991" ; oboInOwl:hasExactSynonym "Abnormal Neutrophil Cell Number" ; a owl:Class ; rdfs:label "Abnormal Neutrophil Count" ; rdfs:subClassOf obo:HP_0001874, obo:HP_0002715 . obo:HP_0012100 obo:IAO_0000115 "An abnormal concentration of creatinine in the blood." ; obo:SCDO_0000340 obo:HP_0012100 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000541" ; oboInOwl:hasDbXref "HP:0012100" ; oboInOwl:hasExactSynonym "Abnormal Blood Creatinine Level", "Abnormal Serum Creatinine Level", "Creatinine Levels Abnormal" ; a owl:Class ; rdfs:label "Abnormal Circulating Creatinine Level" ; rdfs:subClassOf obo:HP_0004364 . obo:HP_0012101 obo:IAO_0000115 "An abnormally reduced amount of creatinine in the blood." ; obo:SCDO_0000340 obo:HP_0012101 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000648" ; oboInOwl:hasDbXref "HP:0012101" ; oboInOwl:hasExactSynonym "Low Blood Creatinine", "Low Serum Creatinine", "Reduced Creatinine Levels" ; a owl:Class ; rdfs:label "Decreased Serum Creatinine" ; rdfs:subClassOf obo:HP_0012100 . obo:HP_0012203 obo:IAO_0000115 "A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split." ; obo:SCDO_0000340 obo:HP_0012203 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000831" ; dc:source "Medscape: Onychomycosis: Author: Antonella Tosti, MD; Chief Editor: Dirk M Elston, MD et al.." ; oboInOwl:hasDbXref "HP:0012203" ; a owl:Class ; rdfs:comment """has disease stage: Distal lateral subungual onychomycosis (DLSO), White superficial onychomycosis (WSO), Proximal subungual onychomycosis (PSO), Endonyx onychomycosis (EO), Candidal onychomycosis. Is characterised by: Disfigured nails, pain, paraesthesia, loss of dexterity, difficulty walking, standing, exercise.""" ; rdfs:label "Onychomycosis" ; rdfs:subClassOf obo:NCIT_C3245, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:IDO_0000560 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0012229 obo:IAO_0000115 "An increased white blood cell count in the cerebrospinal fluid." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0012229" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000212" ; oboInOwl:hasDbXref "HP:0012229" ; oboInOwl:hasExactSynonym "CSF Pleocytosis", "Increased Leukocyte Count in CSF" ; a owl:Class ; rdfs:label "Cerebrospinal Fluid Pleocytosis" ; rdfs:subClassOf obo:HP_0002060 . obo:HP_0012243 obo:IAO_0000115 "A structural or developmental anomaly of any of the tissues involved in the genital system." ; obo:SCDO_0000340 obo:HP_0012243 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009817" ; oboInOwl:hasDbXref "HP:0012243" ; oboInOwl:hasExactSynonym "Abnormal Genital System Morphology" ; a owl:Class ; rdfs:label "Abnormal Reproductive System Morphology" ; rdfs:subClassOf obo:HP_0000078 . obo:HP_0012282 obo:IAO_0000115 "An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days." ; obo:SCDO_0000340 obo:HP_0012282 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000770" ; oboInOwl:hasDbXref "HP:0012282" ; a owl:Class ; rdfs:comment "A morbilliform rash is said to resemble the rash of measles, rubella or scarlet fever, thus mimicking viral and bacterial exanthemas." ; rdfs:label "Morbilliform Rash" ; rdfs:subClassOf obo:HP_0011122, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:HP_0012330 obo:IAO_0000115 "An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0012330" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005758" ; oboInOwl:hasDbXref "HP:0012330" ; a owl:Class ; rdfs:label "Pyelonephritis" ; rdfs:subClassOf obo:HP_0000123, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0012379 obo:IAO_0000115 "An altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme." ; obo:SCDO_0000340 obo:HP_0012379 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000665" ; oboInOwl:hasDbXref "HP:0012379" ; a owl:Class ; rdfs:label "Abnormal Enzyme/Coenzyme Activity" ; rdfs:subClassOf obo:SCDO_0002674 . obo:HP_0012418 obo:IAO_0000115 "An abnormally low level of blood oxygen." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0012418" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000604" ; oboInOwl:hasDbXref "HP:0012418" ; oboInOwl:hasExactSynonym "Decreased Partial Pressure of Oxygen", "Low Blood Oxygen Level" ; a owl:Class ; rdfs:label "Hypoxemia" ; rdfs:subClassOf obo:MP_0002329, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0012444 obo:IAO_0000115 "Partial or complete wasting (loss) of brain tissue that was once present." ; obo:SCDO_0000340 obo:HP_0012444 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000089" ; oboInOwl:hasDbXref "HP:0012444" ; oboInOwl:hasExactSynonym "Brain Atrophy", "Brain Degeneration", "Brain Wasting" ; a owl:Class ; rdfs:label "Atrophic Brain" ; rdfs:subClassOf obo:HP_0012639 . obo:HP_0012465 obo:IAO_0000115 "An increased level of iron in liver tissues." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0012465" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000425" ; oboInOwl:hasDbXref "HP:0012465" ; oboInOwl:hasExactSynonym "Increased Iron Concentration in Liver", "Increased Liver Iron Level" ; a owl:Class ; rdfs:comment """This abnormality can be measured by liver biopsy or by hepatic magnetic resonance imaging. Equivalents""" ; rdfs:label "Elevated Hepatic Iron Concentration" ; rdfs:subClassOf obo:HP_0001392, obo:NCIT_C115224 . obo:HP_0012532 obo:IAO_0000115 "Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months." ; obo:SCDO_0000340 obo:HP_0012532 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001415" ; oboInOwl:hasDbXref "HP:0012532" ; oboInOwl:hasExactSynonym "Long-Lasting Pain" ; a owl:Class ; rdfs:label "Chronic Pain" ; rdfs:subClassOf obo:SCDO_0000851, obo:SCDO_0001334, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0012574 obo:IAO_0000115 "Increased numbers of mesangial cells per glomerulus, defined as four or more nuclei in a peripheral mesangial segment." ; obo:SCDO_0000340 obo:HP_0012574 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006481" ; oboInOwl:hasDbXref "HP:0012574" ; oboInOwl:hasExactSynonym "Mesangial Proliferation" ; a owl:Class ; rdfs:label "Mesangial Hypercellularity" ; rdfs:subClassOf obo:HP_0000077 . obo:HP_0012587 obo:IAO_0000115 "Hematuria that is visible upon inspection of the urine." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0012587" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008145" ; oboInOwl:hasDbXref "HP:0012587" ; oboInOwl:hasExactSynonym "Bloody Urine", "Gross Hematuria" ; a owl:Class ; rdfs:label "Macroscopic Hematuria" ; rdfs:subClassOf obo:SCDO_0000508, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:HP_0012594 obo:IAO_0000115 "The presence of mildly increased concentrations of albumin in the urine (in adults, 30-150 mg per day)." ; obo:SCDO_0000340 obo:HP_0012594, , "http://patient.info/doctor/microalbuminuria" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000764" ; dc:source "Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care; NICE Clinical Guidelines (July 2014)" ; oboInOwl:hasDbXref "HP:0012594" ; oboInOwl:hasExactSynonym "Micro-albuminuria", "Microalbuminuria", "Mildly Increased Albuminuria", "Moderately Increased Albuminuria" ; a owl:Class ; rdfs:comment "The criteria for clinically significant proteinuria have been changed from an albumin-creatinine ratio (ACR) of 30 mg/mmol or more to 3 mg/mmol or more. This is because there is evidence that the risk of adverse outcomes is a continuum and starts at an ACR well below 30 mg/mmol." ; rdfs:label "Low Level Albuminuria" ; rdfs:subClassOf obo:SCDO_0000037, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001210 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001212 ] . obo:HP_0012638 obo:IAO_0000115 "A functional anomaly of the nervous system." ; obo:SCDO_0000340 obo:HP_0012638 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000765" ; oboInOwl:hasDbXref "HP:0012638" ; oboInOwl:hasExactSynonym "Abnormality of Nervous System Physiology" ; a owl:Class ; rdfs:label "Abnormal Nervous System Physiology" ; rdfs:subClassOf obo:HP_0000707 . obo:HP_0012639 obo:IAO_0000115 "A structural anomaly of the nervous system." ; obo:SCDO_0000340 obo:HP_0012639 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000764" ; oboInOwl:hasDbXref "HP:0012639" ; oboInOwl:hasExactSynonym "Abnormal Shape of Nervous System", "Abnormality of Nervous System Morphology" ; a owl:Class ; rdfs:label "Abnormal Nervous System Morphology" ; rdfs:subClassOf obo:HP_0000707 . obo:HP_0012735 obo:IAO_0000115 "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." ; obo:SCDO_0000340 obo:HP_0012735 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004069" ; oboInOwl:hasDbXref "HP:0012735" ; a owl:Class ; rdfs:label "Cough" ; rdfs:subClassOf obo:HP_0002086 . obo:HP_0012759 obo:IAO_0000115 "A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities. This term should be used to describe abnormalities with onset in the developmental period." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0012759" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000800" ; oboInOwl:hasDbXref "HP:0012759" ; a owl:Class ; rdfs:label "Neurodevelopmental Abnormality" ; rdfs:subClassOf obo:HP_0012638 . obo:HP_0012819 obo:IAO_0000115 "Inflammation of the myocardium." ; obo:SCDO_0000340 obo:HP_0012819 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004203" ; dc:source obo:HP_0012819 ; oboInOwl:hasDbXref "HP:0012819" ; a owl:Class ; rdfs:comment "Myocarditis can be caused by a variety of bacterial and viral infections. Enteroviruses, especially coxsackievirus B, are often associated with acute myocarditis. However, with the advent of genetic analysis, adenovirus and parvovirus B19 have also been found to be frequent causes of myocarditis. Exposure to drug treatment, physical stimuli such as radiation and heat, metabolic disorders, immune disorders, and pregnancy are also causes of myocarditis. Many cases of myocarditis are idiopathic. Myocarditis presents with non-specific symptoms including chest pain, dyspnoea, and palpitations, and thus often mimics more common disorders such as coronary artery disease. In some patients, cardiac MRI and endomyocardial biopsy can help identify myocarditis, predict risk of cardiovascular events, and guide treatment." ; rdfs:label "Myocarditis" ; rdfs:subClassOf obo:HP_0030680 . obo:HP_0020054 obo:IAO_0000115 "Any functional abnormality of erythrocytes (red-blood cells)." ; obo:SCDO_0000340 obo:HP_0020054 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000286" ; oboInOwl:hasDbXref "HP:0020054" ; a owl:Class ; rdfs:label "Abnormal Erythrocyte Physiology" ; rdfs:subClassOf obo:HP_0001871 . obo:HP_0020058 obo:IAO_0000115 "Any deviation from the normal number of red blood cells per volume in the circulation." ; obo:SCDO_0000340 obo:HP_0020058 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000608" ; oboInOwl:hasDbXref "HP:0020058" ; oboInOwl:hasExactSynonym "Abnormal RBC Count" ; a owl:Class ; rdfs:label "Abnormal Red Blood Cell Count" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0020059 obo:IAO_0000115 "An abnormal elevation above the normal number of red blood cells per volume in the circulation." ; obo:SCDO_0000340 obo:HP_0020059 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000610" ; oboInOwl:hasDbXref "HP:0020059" ; oboInOwl:hasExactSynonym "Increased RBC Count" ; a owl:Class ; rdfs:label "Increased Red Blood Cell Count" ; rdfs:subClassOf obo:HP_0020058 . obo:HP_0020060 obo:IAO_0000115 "An abnormal reduction below the normal number of red blood cells per volume in the circulation." ; obo:SCDO_0000340 obo:HP_0020060 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000609" ; oboInOwl:hasDbXref "HP:0020060" ; oboInOwl:hasExactSynonym "Decreased RBC Count" ; a owl:Class ; rdfs:label "Decreased Red Blood Cell Count" ; rdfs:subClassOf obo:HP_0020058 . obo:HP_0020061 obo:IAO_0000115 "Any deviation from the normal concentration of hemoglobin in the blood." ; obo:SCDO_0000303 """It might seem wrong to place this class here, but note that a change in hemoglobin concentration affects the size/volume and hence morphology of erythrocytes. Perhaps add sub-classes \"Increased hemoglobin concentration\" and \"Decreased hemoglobin concentration\" from HPO...their descriptions don't seem quite right though (should it not rather be \"in the erythrocytes\", not \"in the circulation\"?""" ; obo:SCDO_0000340 obo:HP_0020061 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000186" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "HP:0020061" ; a owl:Class ; rdfs:label "Abnormal Hemoglobin Concentration" ; rdfs:subClassOf obo:HP_0001877, obo:SCDO_0009613 . obo:HP_0020062 obo:IAO_0000115 "An abnormal reduction below normal hemoglobin concentration in the circulation." ; obo:SCDO_0000340 obo:HP_0020062 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000377" ; oboInOwl:hasDbXref "HP:0020062" ; a owl:Class ; rdfs:label "Decreased Hemoglobin Concentration" ; rdfs:subClassOf obo:HP_0020061 . obo:HP_0020063 obo:IAO_0000115 "An abnormal elevation above normal hemoglobin concentration in the circulation." ; obo:SCDO_0000340 obo:HP_0020063 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000378" ; oboInOwl:hasDbXref "HP:0020063" ; a owl:Class ; rdfs:label "Increased Hemoglobin Concentration" ; rdfs:subClassOf obo:HP_0020061 . obo:HP_0025031 obo:IAO_0000115 "Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus." ; obo:SCDO_0000340 "Kaeda JS, Roper D, Srivastava P, et al. Severe hemolytic anemia associated with the homozygous state for an unstable hemoglobin variant (Hb Bushwick). Blood 1995; 86:1977.", "http://purl.obolibrary.org/obo/HP_0025031" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000335" ; oboInOwl:hasDbXref "HP:0025031" ; a owl:Class ; rdfs:label "Abnormality of the Digestive System" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0025065 obo:IAO_0000115 "A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters." ; obo:SCDO_0000340 obo:HP_0025065 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000624" ; oboInOwl:hasDbXref "HP:0025065" ; oboInOwl:hasExactSynonym "Abnormal Erythrocyte Volume", "Abnormal MCV" ; a owl:Class ; rdfs:label "Abnormal Mean Corpuscular Volume" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0025066 obo:IAO_0000115 "A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters)." ; obo:SCDO_0000340 obo:HP_0025066 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000625" ; oboInOwl:hasDbXref "HP:0025066" ; oboInOwl:hasExactSynonym "Decreased MCV", "Low MCV", "Microcytosis", "Reduced Erythrocyte Volume" ; a owl:Class ; rdfs:label "Decreased Mean Corpuscular Volume" ; rdfs:subClassOf obo:HP_0025065 . obo:HP_0025142 obo:IAO_0000115 "A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual." ; obo:SCDO_0000340 obo:HP_0025142 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000269" ; oboInOwl:hasDbXref "HP:0025142" ; oboInOwl:hasExactSynonym "Systemic Symptom" ; a owl:Class ; rdfs:label "Constitutional Symptom" ; rdfs:subClassOf obo:HP_0000118 . obo:HP_0025435 obo:IAO_0000115 "An elevated level of the enzyme lactate dehydrogenase in serum." ; obo:SCDO_0000340 obo:HP_0025435 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000652" ; oboInOwl:hasDbXref "HP:0025435" ; oboInOwl:hasExactSynonym "High Lactate Dehydrogenase Level" ; a owl:Class ; rdfs:label "Increased Lactate Dehydrogenase Level" ; rdfs:subClassOf obo:HP_0045040 . obo:HP_0025546 obo:IAO_0000115 "Deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." ; obo:SCDO_0000340 obo:MP_0005640 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000631" ; oboInOwl:hasDbXref "HP:0025546" ; oboInOwl:hasExactSynonym "Abnormal MCHC", "Abnormal Mean Cell Haemoglobin Concentration", "Abnormal Mean Cell Hb Concentration", "Abnormal Mean Cell Hemoglobin Concentration", "Abnormal Mean Corpuscular Haemoglobin Concentration", "Abnormal Mean Corpuscular Hb Concentration" ; a owl:Class ; rdfs:label "Abnormal Mean Corpuscular Hemoglobin Concentration" ; rdfs:subClassOf obo:HP_0001877 . obo:HP_0025547 obo:IAO_0000115 "Less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." ; obo:SCDO_0000340 obo:MP_0005642 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000635" ; oboInOwl:hasDbXref "HP:0025547" ; oboInOwl:hasExactSynonym "Decreased MCHC", "Decreased Mean Corpuscular Haemoglobin Concentration", "Low MCHC", "Low Mean Corpuscular Haemoglobin Concentration", "Low Mean Corpuscular Hemoglobin Concentration", "Reduced Mean Corpuscular Haemoglobin Concentration", "Reduced Mean Corpuscular Hemoglobin Concentration" ; a owl:Class ; rdfs:label "Decreased Mean Corpuscular Hemoglobin Concentration" ; rdfs:subClassOf obo:HP_0025546 . obo:HP_0025548 obo:IAO_0000115 "Greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." ; obo:SCDO_0000340 obo:MP_0005641 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000636" ; oboInOwl:hasDbXref "HP:0025548" ; oboInOwl:hasExactSynonym "High MCHC", "High Mean Corpuscular Haemoglobin Concentration", "High Mean Corpuscular Hemoglobin Concentration", "Increased MCHC", "Increased Mean Corpuscular Haemoglobin Concentration" ; a owl:Class ; rdfs:label "Increased Mean Corpuscular Hemoglobin Concentration" ; rdfs:subClassOf obo:HP_0025546 . obo:HP_0025636 obo:IAO_0000115 "Inflammation of the inner lining of the uterus", "Local accumulation of fluid, plasma proteins, and leukocytes in the endometrium." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MP_0009360" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000433" ; oboInOwl:hasDbXref "HP:0025636" ; oboInOwl:hasExactSynonym "Endometrial Inflammation", "Endometrium Inflammation" ; a owl:Class ; rdfs:label "Endometritis" ; rdfs:subClassOf obo:HP_0000078 . obo:HP_0030049 obo:IAO_0000115 "A collection of pus, immune cells, and other material in the brain." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0030049" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000159" ; oboInOwl:hasDbXref "HP:0030049" ; a owl:Class ; rdfs:comment "Brain abscess usually results from a bacterial or fungal infection." ; rdfs:label "Brain Abscess" ; rdfs:subClassOf obo:HP_0002715, obo:HP_0012639, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000139 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000420 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000963 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:IDO_0000560 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0030050 obo:IAO_0000115 "An abnormal phenomenon characterized by a classic tetrad of excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination, and sleep paralysis." ; obo:SCDO_0000303 obo:HP_0030050 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000790" ; oboInOwl:hasDbXref "HP:0030050" ; a owl:Class ; rdfs:label "Narcolepsy" ; rdfs:subClassOf obo:HP_0000708, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OGMS_0000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ] . obo:HP_0030058 obo:IAO_0000115 "An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains)." ; obo:SCDO_0000340 obo:HP_0030058 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000246" ; oboInOwl:hasDbXref "HP:0030058" ; oboInOwl:hasExactSynonym "Banana Cell", "Drepanocyte", "Sickle Cell", "Sickled Erythrocyte", "Sickled Red Blood Cell" ; a owl:Class ; rdfs:label "Sickled Erythrocyte" ; rdfs:subClassOf obo:HP_0004447 . obo:HP_0030127 obo:IAO_0000115 "The growth of endometrial tissue outside the uterus." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0030127" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000432" ; oboInOwl:hasDbXref "HP:0030127" ; a owl:Class ; rdfs:label "Endometriosis" ; rdfs:subClassOf obo:HP_0012243, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0030243 obo:IAO_0000115 "An obstruction in the veins of the liver caused by a blood clot (thrombosis)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0030243" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001673" ; oboInOwl:hasDbXref "HP:0030243" ; oboInOwl:hasExactSynonym "Blood Clot in Liver Vein" ; a owl:Class ; rdfs:label "Hepatic Vein Thrombosis" ; rdfs:subClassOf obo:HP_0001977, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:HP_0030248 obo:IAO_0000115 "A clot that obstructs blood flow in a mesenteric vein (the superior and the inferior mesenteric vein drain blood from the small and large intestine)." ; obo:SCDO_0000340 obo:HP_0030248 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004437" ; oboInOwl:hasDbXref "HP:0030248" ; oboInOwl:hasExactSynonym "Blood Clot in Mesenteric Vein" ; a owl:Class ; rdfs:label "Mesenteric Venous Thrombosis" ; rdfs:subClassOf obo:HP_0001977 . obo:HP_0030680 obo:IAO_0000115 "Any structural anomaly of the heart and great vessels." ; obo:SCDO_0000340 obo:HP_0030680 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000369" ; oboInOwl:hasDbXref "HP:0030680" ; a owl:Class ; rdfs:label "Abnormal Cardiovascular System Morphology" ; rdfs:subClassOf obo:HP_0001626 . obo:HP_0031368 obo:IAO_0000115 "A hole (perforation) in the wall of the intestine." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000434" ; oboInOwl:hasDbXref "HP:0031368" ; a owl:Class ; rdfs:label "Intestinal Perforation" ; rdfs:subClassOf obo:SCDO_1000433 . obo:HP_0031456 obo:IAO_0000115 "A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube)." ; obo:SCDO_0000340 obo:HP_0031456 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000413" ; oboInOwl:hasDbXref "HP:0031456" ; a owl:Class ; rdfs:label "Ectopic Pregnancy" ; rdfs:subClassOf obo:NCIT_C34941, obo:SCDO_1000371 . obo:HP_0031956 obo:IAO_0000115 "An abnormally high concentration in the circulation of aspartate aminotransferase (AST)." ; obo:SCDO_0000340 obo:HP_0031956 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000661" ; oboInOwl:hasDbXref "HP:0031956" ; oboInOwl:hasExactSynonym "Aspartate Aminotransferase Increased", "Elevated Serum AST", "Elevated Serum Glutamic Oxaloacetic Transaminase", "Increased Aspartate Aminotransferase" ; a owl:Class ; rdfs:label "Elevated Serum Aspartate Aminotransferase" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0031964 obo:IAO_0000115 "An abnormally high concentration in the circulation of alanine aminotransferase (ALT), which is an enzyme that catalyzes the transfer of amino groups to form the hepatic metabolite oxaloacetate. ALT is found abundantly in the cytosol of the hepatocyte. ALT activity in the liver is about 3000 times that of serum activity. Thus, in the case of hepatocellular injury or death, release of ALT from damaged liver cells increases measured ALT activity in the serum. Although it is generally thought to be specific to the liver, it is also found in the kidney, and, in much smaller quantities, in heart and skeletal muscle cells." ; obo:SCDO_0000340 obo:HP_0031964 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000659" ; oboInOwl:hasDbXref "HP:0031964" ; oboInOwl:hasExactSynonym "Alanine Aminotransferase Increased", "Elevated Serum Glutamic-Pyruvic Transaminase", "Elevated serum ALT" ; a owl:Class ; rdfs:label "Elevated Serum Alanine Aminotransferase" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0032180 obo:IAO_0000115 "An abnormal level of an analyte measured in the blood." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000437" ; oboInOwl:hasDbXref "HP:0032180" ; a owl:Class ; rdfs:label "Abnormal Circulating Metabolite Concentration" ; rdfs:subClassOf obo:MP_0009642 . obo:HP_0032224 obo:IAO_0000115 "The ABO histo-blood group consists of two antigens (A and B antigens) and four blood types (types A, B, AB, and O). The A and B antigens are the product of the ABO gene and are autosomal codominant. The group O phenotype is an autosomal-recessive phenotype due to the homozygous inheritance of two null ABO alleles. Group O individuals express the H antigen, the biosynthetic precursor to A and B antigens. ABO, therefore, is the blood type, whereas A, B, and H refer to the antigens. The ABO system consists of A and B antigens and antibodies against these antigens." ; obo:SCDO_0000340 obo:HP_0032224 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000581" ; oboInOwl:hasDbXref "HP:0032224" ; a owl:Class ; rdfs:label "ABO Blood Group" ; rdfs:subClassOf obo:SCDO_0009884 . obo:HP_0045040 obo:IAO_0000115 "A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate." ; obo:SCDO_0000340 obo:HP_0045040 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000683" ; oboInOwl:hasDbXref "HP:0045040" ; a owl:Class ; rdfs:label "Abnormal Lactate Dehydrogenase Level" ; rdfs:subClassOf obo:HP_0012379 . obo:HP_0045048 obo:IAO_0000115 "An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0045048" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000630" ; oboInOwl:hasDbXref "HP:0045048" ; oboInOwl:hasExactSynonym "Increased HbA2 Hemoglobin" ; a owl:Class ; rdfs:label "Increased Hemoglobin A2" ; rdfs:subClassOf obo:HP_0020063, obo:SCDO_1000061 . obo:HP_0100601 obo:IAO_0000115 "An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders." ; obo:SCDO_0000340 obo:HP_0100601 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000411" ; oboInOwl:hasDbXref "HP:0100601" ; a owl:Class ; rdfs:label "Eclampsia" ; rdfs:subClassOf obo:NCIT_C34941, obo:SCDO_1000371, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000256 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:HP_0100602 obo:IAO_0000115 "Pregnancy-induced hypertension in association with significant amounts of protein in the urine." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0100602" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000918" ; oboInOwl:hasDbXref "HP:0100602" ; oboInOwl:hasExactSynonym "Pre-Eclampsia" ; a owl:Class ; rdfs:label "Preeclampsia" ; rdfs:subClassOf obo:NCIT_C34941, obo:SCDO_0000267, obo:SCDO_1000371, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0100614 obo:IAO_0000115 "A general term for inflammation of the muscles without respect to the underlying cause." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0100614" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000785" ; oboInOwl:hasDbXref "HP:0100614" ; oboInOwl:hasExactSynonym "Muscle Inflammation" ; a owl:Class ; rdfs:label "Myositis" ; rdfs:subClassOf obo:HP_0002715, obo:SCDO_1000268, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0100749 obo:IAO_0000115 "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest." ; obo:SCDO_0000340 obo:HP_0100749 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001988" ; oboInOwl:hasDbXref "HP:0100749" ; oboInOwl:hasExactSynonym "Thoracic Pain" ; a owl:Class ; rdfs:label "Chest Pain" ; rdfs:subClassOf obo:SCDO_0000851 . obo:HP_0100774 obo:IAO_0000115 "Excessive growth or abnormal thickening of bone tissue." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0100774" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000591" ; oboInOwl:hasDbXref "HP:0100774" ; oboInOwl:hasExactSynonym "Bone Hypertrophy", "Bone Overgrowth" ; a owl:Class ; rdfs:label "Hyperostosis" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:HP_0100806 obo:IAO_0000115 "Severe systemic inflammatory response to infection." ; obo:SCDO_0000303 """Perhaps remove here and only keep below \"Abnormality of the Immune System\"? Source needed for additional information. Perhaps include different types of sepsis (see under D018805 in MESH)?""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0100806" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001039" ; oboInOwl:hasDbXref "HP:0100806" ; a owl:Class ; rdfs:comment """caused by: Bacteria and fungus mainly characterised by: Systematic manifestations of inflammation has disease stage: Mild, moderate, severe""" ; rdfs:label "Sepsis" ; rdfs:subClassOf obo:HP_0002715, obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000139 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:IDO_0000560 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:HP_0100820 obo:IAO_0000115 "Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0100820" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000459" ; oboInOwl:hasDbXref "HP:0100820" ; oboInOwl:hasExactSynonym "Diseased Glomeruli", "Glomerulopathies" ; a owl:Class ; rdfs:label "Glomerulopathy" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:HP_0200042 obo:IAO_0000115 "A discontinuity of the skin exhibiting loss of the epidermis and often portions of the dermis and subcutaneous fat." ; obo:SCDO_0000303 "Find source for additional info" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0200042" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001074" ; oboInOwl:hasDbXref "HP:0200042" ; oboInOwl:hasExactSynonym "Open Skin Sore", "Skin Ulcers" ; a owl:Class ; rdfs:label "Skin Ulcer" ; rdfs:subClassOf obo:HP_0011121, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:HP_0500015 obo:IAO_0000115 "Abnormal test result of cardiovascular physiology." ; obo:SCDO_0000340 obo:HP_0500015 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000266" ; oboInOwl:hasDbXref "HP:0500015" ; a owl:Class ; rdfs:label "Abnormal Cardiac Test" ; rdfs:subClassOf obo:HP_0001626 . obo:HsapDv_0000000 obo:IAO_0000115 "A spatiotemporal region encompassing some part of the life cycle of an organism." ; obo:SCDO_0000303 "See specific stages in the \"Human Developmental Stages Ontology\"" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HsapDv_0000000" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007384" ; oboInOwl:hasDbXref "HsapDv:0000000" ; oboInOwl:hasExactSynonym "Developmental Stage" ; a owl:Class ; rdfs:label "Human Life Cycle Stage" ; rdfs:subClassOf obo:NCIT_C43646 . obo:IAO_0000115 obo:IAO_0000115 "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions." ; obo:SCDO_0000340 obo:IAO_0000115 ; obo:SCDO_0000363 "no" ; a owl:AnnotationProperty ; rdfs:label "definition" . obo:IAO_0000412 obo:IAO_0000115 "For external terms/classes, the ontology from which the term was imported." ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; oboInOwl:hasDbXref "IAO:0000412" ; a owl:AnnotationProperty ; rdfs:label "imported from" . obo:IAO_0100001 obo:IAO_0000115 "Use on obsolete terms, relating the term to another term that can be used as a substitute." ; obo:SCDO_0000340 obo:IAO_0100001 ; oboInOwl:hasDbXref "IAO:0100001" ; a owl:AnnotationProperty ; rdfs:label "term replaced by" . obo:ICO_0000036 obo:IAO_0000115 "A date specification that designates when an informed consent form was signed." ; obo:SCDO_0000340 obo:ICO_0000036 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000531" ; oboInOwl:hasDbXref "ICO:0000036" ; oboInOwl:hasExactSynonym "Date Subject Signed Consent", "Informed Consent Form Signing Date" ; a owl:Class ; rdfs:label "Date of Signing Consent" ; rdfs:subClassOf obo:SCDO_1000522 . obo:ICO_0000157 obo:IAO_0000115 "An informed consent by the parent/guardian of a child or a minor to consent to give permission for the child/minor to be included in research." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009293" ; oboInOwl:hasDbXref "ICO:0000157" ; oboInOwl:hasExactSynonym "Parental Informed Consent Process", "Parental Permission", "Parental Permission Consent" ; a owl:Class ; rdfs:label "Parental Consent" ; rdfs:subClassOf obo:SCDO_0003712, obo:SCDO_0007087 . obo:ICO_0000179 obo:IAO_0000115 "An informed consent for an unspecified range of future research subject to a few content and/or process restrictions." ; obo:SCDO_0000340 obo:ICO_0000179 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008115" ; oboInOwl:hasDbXref "ICO:0000179" ; a owl:Class ; rdfs:label "Broad Consent" ; rdfs:subClassOf obo:SCDO_0007087 . obo:ICO_0000228 obo:IAO_0000115 "A planned process in which data possessed by one person or organization is shared with one or more other persons or organizations." ; obo:SCDO_0000340 obo:ICO_0000228 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009586" ; oboInOwl:hasDbXref "ICO:0000228" ; oboInOwl:hasExactSynonym "Act of Data Sharing" ; a owl:Class ; rdfs:label "Data Sharing" ; rdfs:subClassOf obo:SCDO_0006339 . obo:ICO_0000255 obo:IAO_0000115 "A directive information entity that prescribes some process for withdraw from another planned process." ; obo:SCDO_0000340 obo:ICO_0000255 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000428" ; oboInOwl:hasDbXref "ICO:0000255" ; oboInOwl:hasExactSynonym "Withdrawal from Participation Directive" ; a owl:Class ; rdfs:label "Participant Withdrawal Process" ; rdfs:subClassOf obo:SCDO_1000422 . obo:ICO_0000278 obo:IAO_0000115 "A descriptive information content entity that describes how biospecimens will be used." ; obo:SCDO_0000340 obo:ICO_0000278 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000456" ; oboInOwl:hasDbXref "ICO:0000278" ; a owl:Class ; rdfs:label "Description of Future Biospecimen Use" ; rdfs:subClassOf obo:ICO_0000305 . obo:ICO_0000293 obo:IAO_0000115 "A directive information entity that prescribes the information that is permitted to be shared or the processes for sharing that information." ; obo:SCDO_0000340 obo:ICO_0000293 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000407" ; oboInOwl:hasDbXref "ICO:0000293" ; oboInOwl:hasExactSynonym "Data Sharing Directive" ; a owl:Class ; rdfs:label "Data Sharing Agreement" ; rdfs:subClassOf obo:SCDO_1000406 . obo:ICO_0000304 obo:IAO_0000115 "A descriptive information content entity that describes how data will be used." ; obo:SCDO_0000340 obo:ICO_0000304 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000453" ; oboInOwl:hasDbXref "ICO:0000304" ; a owl:Class ; rdfs:label "Description of Future Data Use" ; rdfs:subClassOf obo:ICO_0000305 . obo:ICO_0000305 obo:IAO_0000115 "A descriptive information content entity that describes future use of material or information." ; obo:SCDO_0000340 obo:ICO_0000305 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000454" ; oboInOwl:hasDbXref "ICO:0000305" ; a owl:Class ; rdfs:label "Description of Future Use" ; rdfs:subClassOf obo:SCDO_1000422 . obo:IDOMAL_0000122 obo:IAO_0000115 "The use of antimalarial drugs for the prevention of infection." ; obo:SCDO_0000340 obo:IDOMAL_0000122 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000668" ; oboInOwl:hasDbXref "IDOMAL:0000122" ; a owl:Class ; rdfs:label "Malaria Chemoprophylaxis" ; rdfs:subClassOf obo:SCDO_0000709 . obo:IDOMAL_0000592 obo:IAO_0000115 "Any process carried out to determine the condition of a patient's spleen." ; obo:SCDO_0000303 "Needs relating to Splenomegaly phenotype." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/IDOMAL_0000592" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001101" ; oboInOwl:hasDbXref "IDOMAL:0000592" ; a owl:Class ; rdfs:label "Spleen Examination" ; rdfs:subClassOf obo:SCDO_0000898 . obo:IDOMAL_50000026 obo:IAO_0000115 "A permanent change in the DNA sequence of a gene that alters the genetic message carried by that gene." ; obo:SCDO_0000303 "Perhaps include here an \"Alpha Thalassemia Mutation\" sub-class? Could use the current description for \"Alpha-Globin Locus Deletion\" and instead give \"Alpha-Globin Locus Deletion\" a description similar to that of \"Beta-Globin Locus Deletion\"" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/IDOMAL_50000026" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001370" ; oboInOwl:hasDbXref "IDOMAL:50000026" ; a owl:Class ; rdfs:label "Mutation" ; rdfs:subClassOf obo:SCDO_0001369, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C26548 ] . obo:IDO_0000515 obo:IAO_0000115 "An organism population whose members are particpating in non-parasitic symbiosis with a particular host." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/IDO_0000515" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000755" ; oboInOwl:hasDbXref "IDO:0000515" ; oboInOwl:hasExactSynonym "Normal Resident Microbiota Population", "Normal Resident Microflora Population" ; a owl:Class ; rdfs:label "Microbiome" ; rdfs:subClassOf obo:SCDO_0000122 . obo:IDO_0000560 obo:IAO_0000115 "A material entity bearing an antifungal disposition." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/IDO_0000560" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000019" ; oboInOwl:hasDbXref "IDO:0000560" ; a owl:Class ; rdfs:label "Antifungal" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000388 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0006689 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0008404 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0012203 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0030049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0100806 ] . obo:IDO_0000586 obo:IAO_0000115 "A part of an extended organism that itself has as part a population of one or more infectious agents and that (1) exists as a result of processes initiated by members of the infectious agent population and is (2) clinically abnormal in virtue of the presence of this infectious agent population, or (3) has a disposition to bring clinical abnormality to immunocompetent organisms of the same Species as the host (the organism corresponding to the extended organism) through transmission of a member or offspring of a member of the infectious agent population." ; obo:SCDO_0000303 """Perhaps use Bacterial Infection and Viral Infection as modifiers? Include here \"transfusion-related hepatitis infections\" and or \"viral hepatitis\" (See paper \"Liver involvement in sickle cell disease\" by Emel GÜRKAN et al.)""" ; obo:SCDO_0000340 obo:IDO_0000586 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000635" ; oboInOwl:hasDbXref "IDO:0000586" ; a owl:Class ; rdfs:label "Infection" ; rdfs:subClassOf obo:DOID_4, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:MP_0001212 obo:IAO_0000115 "Focal pathological and/or inflammatory changes characterized by alteration in the size, shape and organization of the cellular components of the skin." ; obo:SCDO_0000340 obo:MP_0001212 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001072" ; oboInOwl:hasDbXref "MP:0001212" ; a owl:Class ; rdfs:label "Skin Lesions" ; rdfs:subClassOf obo:HP_0011123 . obo:MP_0001589 obo:IAO_0000115 "Anomalies in the average levels of hemoglobin contained in an erythrocyte." ; obo:SCDO_0000340 obo:MP_0001589 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000632" ; oboInOwl:hasDbXref "MP:0001589" ; oboInOwl:hasExactSynonym "Abnormal MCH", "Abnormal Mean Cell Hemoglobin", "Abnormal Mean Cell Hemoglobin Level", "Abnormal Mean Corpuscular Hemoglobin Level" ; a owl:Class ; rdfs:label "Abnormal Mean Corpuscular Hemoglobin" ; rdfs:subClassOf obo:HP_0001877 . obo:MP_0001762 obo:IAO_0000115 "Increased volume of urine produced and excreted." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MP_0001762" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000395" ; oboInOwl:hasDbXref "MP:0001762" ; oboInOwl:hasExactSynonym "Increased Urine Output", "Increased Urine Volume", "Polyuria" ; a owl:Class ; rdfs:comment "Clinicians sometimes mistakenly label increased urinary frequency as polyuria (increased urine output); Though rarely used, pollakisuria (or pollakiuria) is the correct term for increased frequency of urination." ; rdfs:label "Diuresis" ; rdfs:subClassOf obo:HP_0000079, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:MP_0001792 obo:IAO_0000115 "Reduced ability or inability to self-repair and close wounds." ; obo:SCDO_0000340 obo:MP_0001792 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000622" ; oboInOwl:hasDbXref "MP:0001792" ; oboInOwl:hasExactSynonym "Delayed Wound Healing", "Impaired Wound Repair" ; a owl:Class ; rdfs:label "Impaired Wound Healing" ; rdfs:subClassOf obo:SCDO_0002674, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:MP_0002081 obo:IAO_0000115 "Death anytime within the perinatal period." ; obo:SCDO_0000340 obo:MP_0002081 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000883" ; oboInOwl:hasDbXref "MP:0002081" ; oboInOwl:hasExactSynonym "Perinatal Lethality" ; a owl:Class ; rdfs:label "Perinatal Death" ; rdfs:subClassOf obo:HP_0001197 . obo:MP_0002118 obo:IAO_0000115 "Anomaly in the processes involved in the maintenance of an internal equilibrium of lipids in the fluids and tissues." ; obo:SCDO_0000340 obo:MP_0002118 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000284" ; oboInOwl:hasDbXref "MP:0002118" ; a owl:Class ; rdfs:label "Abnormal Lipid Homeostasis" ; rdfs:subClassOf obo:SCDO_0002674 . obo:MP_0002329 obo:IAO_0000115 "Anomaly in the amount of oxygen and carbon dioxide in the blood." ; obo:SCDO_0000340 obo:MP_0002329 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000810" ; oboInOwl:hasDbXref "MP:0002329" ; a owl:Class ; rdfs:label "Abnormal Blood Gas Level" ; rdfs:subClassOf obo:HP_0002086, obo:MP_0009642 . obo:MP_0002412 obo:IAO_0000115 "Greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MP_0002412" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000632" ; oboInOwl:hasDbXref "MP:0002412" ; oboInOwl:hasExactSynonym "Decreased Resistance to Bacterial infection" ; a owl:Class ; rdfs:comment """Characterised by: Repeated/recurrent local or systemic bacterial infections. Caused by: Multifactorial generally factors ultimately cause impaired immunity.""" ; rdfs:label "Increased Susceptibility to Bacterial Infection" ; rdfs:subClassOf obo:HP_0002715, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000930 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:MP_0003224 obo:IAO_0000115 "A retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses." ; obo:SCDO_0000303 "Provide source for additional info." ; obo:SCDO_0000340 obo:MP_0003224 ; obo:SCDO_0000468 "Usually in the elderly persons. Aging associated with most disorders" ; obo:SCDO_0000661 "Multifactorial causes such as program cell death, genetic mutations, protein misfolding and intracellular mechanisms" ; obo:SCDO_0000662 "Multiple disease entities such as alzhiemers disease, parkinsons disease , huntington's disease and amylotrophic lateral sclerosis" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000802" ; dc:source "http://www.neurodegenerationresearch.eu/about/what/" ; oboInOwl:hasDbXref "MP:0003224" ; oboInOwl:hasExactSynonym "Nerve Degeneration", "Nerve Degenerations", "Neuron Degenerations" ; a owl:Class ; rdfs:label "Neuron Degeneration" ; rdfs:subClassOf obo:HP_0012639 . obo:MP_0005376 obo:IAO_0000115 "The observable morphological and physiological characteristics related to a state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues or the processes that cause many of the chemical changes in living mammalian organisms that are manifested through development and lifespan." ; obo:SCDO_0000340 obo:MP_0005376 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000811" ; oboInOwl:hasDbXref "MP:0005376" ; oboInOwl:hasExactSynonym "Homeostasis Phenotype", "Homeostasis/Metabolism Phenotype" ; a owl:Class ; rdfs:label "Metabolism/Homeostasis Phenotype" ; rdfs:subClassOf obo:OGMS_0000023 . obo:MP_0005533 obo:IAO_0000115 "Greater than the level of heat natural to a living being." ; obo:SCDO_0000340 obo:MP_0005533 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000761" ; oboInOwl:hasDbXref "MP:0005533" ; oboInOwl:hasExactSynonym "Raised Body Temperature" ; a owl:Class ; rdfs:label "Increased Body Temperature" ; rdfs:subClassOf obo:MP_0005535 . obo:MP_0005534 obo:IAO_0000115 "Less than the level of heat natural to a living being." ; obo:SCDO_0000340 obo:MP_0005534 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000762" ; oboInOwl:hasDbXref "MP:0005534" ; oboInOwl:hasExactSynonym "Reduced Body Temperature" ; a owl:Class ; rdfs:label "Decreased Body Temperature" ; rdfs:subClassOf obo:MP_0005535 . obo:MP_0005535 obo:IAO_0000115 "Deviation in the level of heat natural to a living being." ; obo:SCDO_0000340 obo:MP_0005535 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000760" ; oboInOwl:hasDbXref "MP:0005535" ; a owl:Class ; rdfs:label "Abnormal Body Temperature" ; rdfs:subClassOf obo:SCDO_0002674 . obo:MP_0005561 obo:IAO_0000115 "Greater than the average levels of hemoglobin contained in an erythrocyte." ; obo:SCDO_0000340 obo:MP_0005561 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000634" ; oboInOwl:hasDbXref "MP:0005561" ; oboInOwl:hasExactSynonym "High MCH", "High Mean Corpuscular Hemoglobin", "Increased MCH", "Increased Mean Cell Hemoglobin" ; a owl:Class ; rdfs:label "Increased Mean Corpuscular Hemoglobin" ; rdfs:subClassOf obo:MP_0001589 . obo:MP_0005562 obo:IAO_0000115 "Less than the average levels of hemoglobin contained in an erythrocyte." ; obo:SCDO_0000340 obo:MP_0005562 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000633" ; oboInOwl:hasDbXref "MP:0005562" ; oboInOwl:hasExactSynonym "Decreased MCH", "Decreased Mean Cell Hemoglobin", "Low MCH", "Low Mean Corpuscular Hemoglobin" ; a owl:Class ; rdfs:label "Decreased Mean Corpuscular Hemoglobin" ; rdfs:subClassOf obo:MP_0001589 . obo:MP_0009568 obo:IAO_0000115 "A measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress." ; obo:SCDO_0000340 obo:MP_0009568 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000277" ; oboInOwl:hasDbXref "MP:0009568" ; a owl:Class ; rdfs:label "Abnormal Red Blood Cell Deformability" ; rdfs:subClassOf obo:HP_0020054 . obo:MP_0009642 obo:IAO_0000115 "Anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood." ; obo:SCDO_0000340 obo:MP_0009642 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000809" ; oboInOwl:hasDbXref "MP:0009642" ; oboInOwl:hasExactSynonym "Abnormal Blood Chemistry", "Blood Chemistry Abnormalities" ; a owl:Class ; rdfs:label "Abnormal Blood Homeostasis" ; rdfs:subClassOf obo:HP_0001871, obo:SCDO_0002674 . obo:MP_0010066 obo:IAO_0000115 "An anomaly in the coefficient of variance (reference range) of the red blood cell volume for an organism." ; obo:SCDO_0000340 obo:MP_0010066 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000639" ; oboInOwl:hasDbXref "MP:0010066" ; oboInOwl:hasExactSynonym "Abnormal Erythrocyte Distribution Width", "Abnormal RDW" ; a owl:Class ; rdfs:label "Abnormal Red Blood Cell Distribution Width" ; rdfs:subClassOf obo:HP_0001877 . obo:MP_0010067 obo:IAO_0000115 "Higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism." ; obo:SCDO_0000340 obo:MP_0010067 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000641" ; oboInOwl:hasDbXref "MP:0010067" ; oboInOwl:hasExactSynonym "High RCDW", "High RDW", "High Red Blood Cell Distribution Width", "Increased Erythrocyte Distribution Width", "Increased RCDW", "Increased RDW" ; a owl:Class ; rdfs:label "Increased Red Blood Cell Distribution Width" ; rdfs:subClassOf obo:MP_0010066 . obo:MP_0010068 obo:IAO_0000115 "Lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism." ; obo:SCDO_0000340 obo:MP_0010068 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000640" ; oboInOwl:hasDbXref "MP:0010068" ; oboInOwl:hasExactSynonym "Decreased Erythrocyte Distribution Width", "Decreased RCDW", "Decreased RDW", "Low RCDW", "Low RDW", "Low Red Blood Cell Distribution Width", "Reduced RCDW", "Reduced RDW", "Reduced Red Blood Cell Distribution Width" ; a owl:Class ; rdfs:label "Decreased Red Blood Cell Distribution Width" ; rdfs:subClassOf obo:MP_0010066 . obo:MP_0010163 obo:IAO_0000115 "Destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity." ; obo:SCDO_0000340 obo:MP_0010163 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009017" ; oboInOwl:hasDbXref "MP:0010163" ; oboInOwl:hasExactSynonym "Erythrocytolysis", "Erythrolysis", "Haematolysis", "Haemolysis", "Hematolysis", "Hemolyses" ; a owl:Class ; rdfs:label "Hemolysis" ; rdfs:subClassOf obo:HP_0020054 . obo:MP_0011468 obo:IAO_0000115 "Any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group." ; obo:SCDO_0000340 obo:MP_0011468 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000653" ; oboInOwl:hasDbXref "MP:0011468" ; a owl:Class ; rdfs:label "Abnormal Urine Amino Acid Level" ; rdfs:subClassOf obo:HP_0003110 . obo:MP_0011469 obo:IAO_0000115 "Any change in the amount of creatinine in the urine" ; obo:SCDO_0000340 obo:MP_0011469 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000654" ; oboInOwl:hasDbXref "MP:0011469" ; a owl:Class ; rdfs:label "Abnormal Urine Creatinine Level" ; rdfs:subClassOf obo:MP_0011468 . obo:MP_0011470 obo:IAO_0000115 "An increased amount of creatinine in the urine compared to the normal state." ; obo:SCDO_0000340 obo:MP_0011470 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000656" ; oboInOwl:hasDbXref "MP:0011470" ; a owl:Class ; rdfs:label "Increased Urine Creatinine Level" ; rdfs:subClassOf obo:MP_0011469 . obo:MP_0011471 obo:IAO_0000115 "a reduced amount of creatinine in the urine compared to the normal state" ; obo:SCDO_0000340 obo:MP_0011471 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000655" ; oboInOwl:hasDbXref "MP:0011471" ; oboInOwl:hasExactSynonym "Low Urine Creatinine Level", "Reduced Urine Creatinine Level" ; a owl:Class ; rdfs:label "Decreased Urine Creatinine Level" ; rdfs:subClassOf obo:MP_0011469 . obo:MP_0013305 obo:IAO_0000115 "Inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MP_0013305" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000667" ; oboInOwl:hasDbXref "MP:0013305" ; oboInOwl:hasExactSynonym "Impaired Urine-Concentrating Ability", "Urine Concentrating Defect" ; a owl:Class ; rdfs:comment "Urine specific gravity is similar to that of plasma (1.008-1.012)." ; rdfs:label "Isosthenuria" ; rdfs:subClassOf obo:HP_0004727 . obo:NBO_0000131 obo:IAO_0000115 "A drinking behavior associated with the intake of alcohol." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NBO_0000131" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000039" ; oboInOwl:hasDbXref "NBO:0000131" ; oboInOwl:hasExactSynonym "Alcohol Consumption" ; a owl:Class ; rdfs:label "Alcohol Intake" ; rdfs:subClassOf obo:SCDO_0000487 . obo:NCIT_65495 obo:IAO_0000115 "A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C65495" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006467" ; dc:source ; oboInOwl:hasDbXref "NCIT:65495" ; oboInOwl:hasExactSynonym "Cymbalta", "Duloxetine HCl", "N-methyl-3-(1-naphthalenyloxy)-3-(2-thiophene)propanamide" ; a owl:Class ; rdfs:label "Duloxetine" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C101217 obo:IAO_0000115 "An examination of the retina of the eye using an ophthalmoscope." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C101217" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001009" ; oboInOwl:hasDbXref "NCIT:C101217" ; oboInOwl:hasExactSynonym "Fundoscopy" ; a owl:Class ; rdfs:label "Retinal Examination" ; rdfs:subClassOf obo:SCDO_0000835 . obo:NCIT_C102531 obo:IAO_0000115 "A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007383" ; oboInOwl:hasDbXref "NCIT:C102531" ; oboInOwl:hasExactSynonym "Lung Infiltrate" ; a owl:Class ; rdfs:label "Pulmonary Infiltrate" ; rdfs:subClassOf obo:HP_0002086 . obo:NCIT_C102988 obo:IAO_0000115 "A project to develop standards for the collection and analysis of patient-reported health status data using a system of highly reliable, precise measures for physical, mental, and social well-being. Patients are asked a series of rigorously reviewed questions covering common domains and metrics across differing conditions and treatments. The questions can be administered in short forms or adaptively through computerized adaptive testing and reports can be generated to allow clinicians to better understand how treatments might affect the quality of life of their patients." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000871" ; dc:source "Bevans, M., Ross, A., & Cella, D. (2014). Patient-Reported Outcomes Measurement Information System (PROMIS): Efficient, standardized tools to measure self-reported health and quality of life. Nursing Outlook, 62, 339-345.", "Dampier C, Barry V, Gross HE, Lui Y, Thornburg CD, DeWalt DA, Reeve BB. (2016). Initial Evaluation of the Pediatric PROMIS® Health Domains in Children and Adolescents With Sickle Cell Disease. Pediatric Blood & Cancer. Feb 19. doi: 10.1002/pbc.25944.", "DeWitt, E. M., Barnett, K., Farrell, J., Revicki, D., Carle, A., Cook, K., Sherry, D. D. (2014). A164: Development of pediatric item banks to measure pain behavior in the Patient-Reported Outcomes Measurement Information System. Arthritis & Rheumatology, 66(Suppl. 11), S212-S2121." ; oboInOwl:hasDbXref "NCIT:C102988" ; oboInOwl:hasExactSynonym "PROMIS", "Patient Reported Outcomes Measurement Information System" ; a owl:Class ; rdfs:label "Patient Reported Outcomes Measurement Information System (PROMIS)" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297 . obo:NCIT_C103165 obo:IAO_0000115 "The kind of visit undertaken by the subject within a study, such as inpatient, outpatient, telephone, etc." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000852" ; oboInOwl:hasDbXref "NCIT:C103165" ; a owl:Class ; rdfs:label "Subject Visit Type" ; rdfs:subClassOf obo:EUPATH_0000310 . obo:NCIT_C103270 obo:IAO_0000115 "The release from the requirement to obtain informed consent during a study that is granted by Human Subject Protection committee for a research institution for a protocol that is being reviewed by the Institutional Review Board." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005773" ; dc:source "International Ethical Guidelines for Health-related Research Involving Humans, Fourth Edition. Geneva. Council for International Organizations of Medical Sciences (CIOMS); 2016." ; oboInOwl:hasDbXref "NCIT:C103270" ; oboInOwl:hasExactSynonym "Consent Waiver", "Waiver Of Informed Consent" ; a owl:Class ; rdfs:comment "Waiver of the requirement of a signed consent form from potential participants or parents of children who are potential participants may be approved by a Research Ethics Committee if the research carries no more than minimal risk (i.e., risk that is no more likely and not greater than that attached to routine medical or psychological examination) and if the procedures to be used are only those for which signed consent forms are not customarily required outside the research context. Such waivers may also be approved when existence of a signed consent form would be an unjustified threat to the participant's confidentiality." ; rdfs:label "Waiver of Consent" ; rdfs:subClassOf obo:SCDO_1000462 . obo:NCIT_C103526 obo:IAO_0000115 "A 9-item scale using each of the 9 DSM-IV criteria with self-reported frequency of \"0\" (not at all) to \"3\" (nearly every day). One of the most widely used instruments to assess depression, PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression, respectively." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000870" ; dc:source "Kroenke K, Spitzer R, Williams W. The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine. 2001; 16: 606-616." ; oboInOwl:hasDbXref "NCIT:C103526" ; oboInOwl:hasExactSynonym "PHQ-9", "PHQ01", "Patient Health Questionnaire - 9 Item", "Patient Health Questionnaire-9" ; a owl:Class ; rdfs:label "Patient Health Questionnaire-9 (PHQ-9)" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297 . obo:NCIT_C107564 obo:IAO_0000115 "Hemoglobin that has a nitric oxide bound to the cysteine at position 93 in the beta-globin chain." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000169" ; oboInOwl:hasDbXref "NCIT:C107564" ; oboInOwl:hasExactSynonym "S-Nitrosated Hemoglobin", "S-Nitrosohemoglobin" ; a owl:Class ; rdfs:label "S-Nitroso-Hemoglobin" ; rdfs:subClassOf obo:NCIT_C16676 . obo:NCIT_C113340 obo:IAO_0000115 "The cessation of menstruation for six months or more in a female that is not pregnant, breastfeeding or menopausal." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001447" ; oboInOwl:hasDbXref "NCIT:C113340" ; a owl:Class ; rdfs:label "Secondary Amenorrhea" ; rdfs:subClassOf obo:HP_0000080 . obo:NCIT_C114300 obo:IAO_0000115 "Hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO). This complex is produced after CO has been inhaled or as a byproduct of hemoglobin, protoporphyrin or dichloromethane catabolism. The heme-CO complex is approximately 200 times more stable than heme-oxygen complexes. Thus, high levels of carboxyhemoglobin in the circulation can lead to tissue hypoxia and death." ; obo:SCDO_0000340 obo:NCIT_C114300 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000168" ; oboInOwl:hasDbXref "NCIT:C114300" ; oboInOwl:hasExactSynonym "COHb" ; a owl:Class ; rdfs:label "Carboxyhemoglobin" ; rdfs:subClassOf obo:NCIT_C16676 . obo:NCIT_C114714 obo:IAO_0000115 "A severe hypersensitivity-like reaction occurring during dialysis due to exposure to the dialysis membrane." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000387" ; oboInOwl:hasDbXref "NCIT:C114714" ; oboInOwl:hasExactSynonym "Dialyzer Reaction" ; a owl:Class ; rdfs:label "Dialysis Membrane Reaction" ; rdfs:subClassOf obo:NCIT_C78254 . obo:NCIT_C114717 obo:IAO_0000115 "A crack or break in a dialysis catheter caused by material weakness or mechanical compression." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000386" ; oboInOwl:hasDbXref "NCIT:C114717" ; a owl:Class ; rdfs:label "Dialysis Catheter Fracture" ; rdfs:subClassOf obo:NCIT_C78254 . obo:NCIT_C115199 obo:IAO_0000115 "Any heart or vascular disorder occurring as a consequence of injury to the cardiovascular system." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000390" ; oboInOwl:hasDbXref "NCIT:C115199" ; a owl:Class ; rdfs:label "Cardiovascular Complication" ; rdfs:subClassOf obo:NCIT_C2959 . obo:NCIT_C115224 obo:IAO_0000115 "Any disorder of the liver occurring as a consequence of injury to the liver parenchyma." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000382" ; oboInOwl:hasDbXref "NCIT:C115224" ; oboInOwl:hasExactSynonym "Liver Complication" ; a owl:Class ; rdfs:label "Hepatic Complication" ; rdfs:subClassOf obo:NCIT_C2959 . obo:NCIT_C115319 obo:IAO_0000115 "Any eye disorder occurring as a consequence of injury to the eye." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000832" ; oboInOwl:hasDbXref "NCIT:C115319" ; oboInOwl:hasExactSynonym "Ophthalmologic Manifestations" ; a owl:Class ; rdfs:label "Ophthalmologic Complication" ; rdfs:subClassOf obo:NCIT_C2959, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C116081 obo:IAO_0000115 "Any issue that arises as a consequence of a problem with a patient's dialysis access." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000391" ; oboInOwl:hasDbXref "NCIT:C116081" ; a owl:Class ; rdfs:label "Dialysis Access Complication" ; rdfs:subClassOf obo:NCIT_C2959 . obo:NCIT_C116161 obo:IAO_0000115 "A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a single pair of PCR primers. It is frequently used in the detection of genetic aberrations in tumors, and can distinguish sequences differing in only a single nucleotide." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003929" ; oboInOwl:hasDbXref "NCIT:C116161" ; oboInOwl:hasExactSynonym "MLPA" ; a owl:Class ; rdfs:label "Multiplex Ligation-Dependent Probe Amplification" ; rdfs:subClassOf obo:SCDO_0000913 . obo:NCIT_C116942 obo:IAO_0000115 "Failure to meet, or late achievement of developmental milestones." ; obo:SCDO_0000340 ; obo:SCDO_0000661 "Can have many different causes, such as genetic causes (like Down syndrome), or complications of pregnancy and birth (like prematurity or infections). Often, however, the specific cause is unknown. Some causes can be easily reversed if caught early enough, such as hearing loss from chronic ear infections, or lead poisoning." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001293" ; dc:source "http://www.med.umich.edu/yourchild/topics/devdel.htm" ; oboInOwl:hasDbXref "NCIT:C116942" ; a owl:Class ; rdfs:label "Developmental Delay" ; rdfs:subClassOf obo:HP_0012759, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C118385 obo:IAO_0000115 "Tissue death resulting from an interruption to the blood supply." ; obo:IAO_0100001 obo:SCDO_0000841 ; obo:SCDO_0000303 "This is a synonym for osteonecrosis in our ontology (SCDO:0000841), which is controversial between different literature. Please check with a clinician if these two terms refer to the same condition." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C118385" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004832" ; oboInOwl:hasDbXref "NCIT:C118385" ; oboInOwl:hasExactSynonym "AVN" ; a owl:Class ; rdfs:label "deprecated-Avascular Necrosis" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:NCIT_C120254 obo:IAO_0000115 "A standardized tool designed to assess an individual's cognitive abilities. It consists of a battery of tests that allow an investigator to conduct a comprehensive cognitive evaluation of IQ." ; obo:SCDO_0000303 "Life stage: Adolescent, Adult", "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the WAIS-IV and the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V). The Working Group recommends providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for the WAIS-IV and the WISC-V for guidance on selecting an age-appropriate test for individuals." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820501" ; obo:SCDO_0000479 "PhenX protocol: Intelligence Scale - 16 to 90 years #820501" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000646" ; oboInOwl:hasDbXref "NCIT:C120254" ; oboInOwl:hasExactSynonym "WAIS-IV", "Wechsler Adult Intelligence Scale - Fourth Edition", "Wechsler Adult Intelligence Scale 4th Edition", "Wechsler Adult Intelligence Scale, Fourth Edition", "Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV)" ; a owl:Class ; rdfs:label "Intelligence Scale - 16 to 90 years" ; rdfs:subClassOf obo:NCIT_C122920 . obo:NCIT_C120255 obo:IAO_0000115 "A battery of tests that allow an investigator to conduct a comprehensive evaluation of a child or adolescent's cognitive ability." ; obo:SCDO_0000303 "It consists of a core battery of subtests, which focus on five specific domains (verbal comprehension, processing speed, visual spatial, working memory, and fluid reasoning), as well as optional ancillary subtests. These ancillary subtests measure areas that are important to areas of academic achievement.", "Life stage: Child, Adolescent", "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the Wechsler Intelligence Scale for Children®-Fifth Edition (WISC-V) and Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI-IV), as well as between the WISC-V and the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV). The Working Group recommends that providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for WISC-V, WPPSI-IV, and WAIS-IV for guidance on selecting an age-appropriate test." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820503" ; obo:SCDO_0000479 "PhenX protocol: Intelligence Scale - 6 to 16 years 11 months #820503" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000648" ; oboInOwl:hasDbXref "NCIT:C120255" ; oboInOwl:hasExactSynonym "WISC-V", "Wechsler Intelligence Scale for Children-Fifth Edition", "Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V)" ; a owl:Class ; rdfs:label "Intelligence Scale - 6 to 16 years 11 months" ; rdfs:subClassOf obo:NCIT_C122920 . obo:NCIT_C120256 obo:IAO_0000115 "A standardized tool designed to assess the cognitive development in preschool and young children (up to age 7 years and 7 months). It consists of a battery of tests that allow an investigator to conduct a comprehensive evaluation of IQ." ; obo:SCDO_0000303 "Life stage: Toddler, Child", "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the WPPSI-IV and the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) and between the WPPSI-IV and the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V). The Working Group recommends that providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for the WPPSI-IV, Bayley-III, and the WISC-V for guidance on selecting an age-appropriate test." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820502" ; obo:SCDO_0000479 "PhenX protocol: Intelligence Scale - 2 years, 6 months to 7 years, 7 months #820502" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000647" ; oboInOwl:hasDbXref "NCIT:C120256" ; oboInOwl:hasExactSynonym "WPPSI-IV", "Wechsler Preschool & Primary Scale of Intelligence 4th Edition", "Wechsler Preschool and Primary Scale of Intelligenc-Fourth Edition", "Wechsler Preschool and Primary Scale of Intelligenc-Fourth Edition (WPPSI-IV)", "Wechsler Preschool and Primary Scale of Intelligence IV" ; a owl:Class ; rdfs:label "Intelligence Scale - 2 years, 6 months to 7 years, 7 months" ; rdfs:subClassOf obo:NCIT_C122920 . obo:NCIT_C122920 obo:IAO_0000115 "An assessment tool designed to measure an individual's cognitive capabilities. It may be general or it may assess abilities in more discrete cognitive domains." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000645" ; oboInOwl:hasDbXref "NCIT:C122920" ; oboInOwl:hasExactSynonym "Intelligence Test" ; a owl:Class ; rdfs:label "Intelligence Scale" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:NCIT_C122931 obo:IAO_0000115 "A diagnostic technique that uses pulsed Doppler ultrasound to both identify blood vessels in the brain and measure the velocity of blood flow through those vessels. It allows a more accurate estimation of stroke risk because it allows outlining of parenchymal structures and visualization of the examined vessels." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C122931" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000613" ; oboInOwl:hasDbXref "NCIT:C122931" ; oboInOwl:hasExactSynonym "TCDi" ; a owl:Class ; rdfs:label "Imaging Transcranial Doppler Ultrasonography" ; rdfs:subClassOf obo:NCIT_C154865, obo:NCIT_C17230 . obo:NCIT_C123446 obo:IAO_0000115 "A continuous electrocardiographic (ECG) recording that utilizes one or more leads that both records and stores data directly to a device worn by the subject, such that the subject need not be restricted to a medical facility, and may be able to participate in their customary activities of daily living." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C123446" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000281" ; oboInOwl:hasDbXref "NCIT:C123446" ; a owl:Class ; rdfs:label "Continuous Ambulatory ECG" ; rdfs:subClassOf obo:SCDO_0000500, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0000416 ] . obo:NCIT_C123667 obo:IAO_0000115 "A standardized rating scale developed by Ziad Nasreddine in 1996 to screen for mild cognitive dysfunction and impairment. This instrument assesses the following cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Global Mental Status Screener - Adult #130701" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000335" ; dc:source ; oboInOwl:hasDbXref "NCIT:C123667" ; oboInOwl:hasExactSynonym "MOCA", "MOCA01", "Montreal Cognitive Assessment", "Montreal Cognitive Assessment Functional Test", "Montreal Cognitive Assessment Questionnaire" ; a owl:Class ; rdfs:label "Global Mental Status Screener - Adult" ; rdfs:subClassOf obo:SCDO_0000455 . obo:NCIT_C124059 obo:IAO_0000115 "A chest X-ray finding indicating the presence of a radio-opaque area in the lung. The opacification is caused by fluid or solid material within the airways or lung parenchyma." ; obo:SCDO_0000303 "Described in the Tanzania guidelines as 'reduced air entry, increased tactile vocal fremitus, and dull percussion at lung bases, usually bilateral'." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C124059" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006222" ; oboInOwl:hasDbXref "NCIT:C124059" ; oboInOwl:hasExactSynonym "Air Space Opacificatio", "Air-Space Shadowing", "Airspace Consolidation", "Airspace Opacification", "Consolidation" ; a owl:Class ; rdfs:label "Pulmonary Consolidation" ; rdfs:subClassOf obo:HP_0030680, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C124065 obo:IAO_0000115 "A measurement of the concentration of iron in the liver as an estimate of body iron load." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C124065" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000555" ; oboInOwl:hasDbXref "NCIT:C124065" ; oboInOwl:hasExactSynonym "Hepatic Iron", "Liver Iron", "Liver Iron Concentration" ; a owl:Class ; rdfs:label "Hepatic Iron Concentration" ; rdfs:subClassOf obo:SCDO_0000728, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:NCIT_C51677 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:NCIT_C124475 obo:IAO_0000115 "A circumferential measurement of the largest part of the upper arm." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C124475" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000758" ; oboInOwl:hasDbXref "NCIT:C124475" ; oboInOwl:hasExactSynonym "MUAC", "MUARMCIR", "Mid-Upper Arm Circumference" ; a owl:Class ; rdfs:label "Mid Upper Arm Circumference" ; rdfs:subClassOf obo:CMO_0000021 . obo:NCIT_C126120 obo:IAO_0000115 "Hemoglobin where the heme group has formed a reversible complex with oxygen (O2) in the lungs. This molecule is found in the systemic arteries and transports O2 from the lungs to the tissues where it is readily released." ; obo:SCDO_0000340 obo:NCIT_C126120 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000275" ; oboInOwl:hasDbXref "NCIT:C126120" ; oboInOwl:hasExactSynonym "HbO2", "Oxyhemoglobin" ; a owl:Class ; rdfs:label "Oxygenated Hemoglobin" ; rdfs:subClassOf obo:NCIT_C16676 . obo:NCIT_C126121 obo:IAO_0000115 "Hemoglobin containing a heme group that is not bound to oxygen (O2). This molecule is normally found in the systemic veins following transit through capillaries and release of O2 into the tissues. Excess deoxyhemoglobin can be associated with hypoxia." ; obo:SCDO_0000340 obo:NCIT_C126121 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000057" ; oboInOwl:hasDbXref "NCIT:C126121" ; oboInOwl:hasExactSynonym "Deoxyhemoglobin" ; a owl:Class ; rdfs:label "Deoxygenated Hemoglobin" ; rdfs:subClassOf obo:NCIT_C16676 . obo:NCIT_C128326 obo:IAO_0000115 "An abscess within the abdomen." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C128326" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008079" ; oboInOwl:hasDbXref "NCIT:C128326" ; a owl:Class ; rdfs:label "Intra-Abdominal Abscess" ; rdfs:subClassOf obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:NCIT_C129072 obo:IAO_0000115 "The persistence of substantial fetal hemoglobin production into adulthood, usually associated with hemoglobinopathies due to mutations in the alpha and/or beta chain of hemoglobin." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000560" ; oboInOwl:hasDbXref "NCIT:C129072" ; oboInOwl:hasExactSynonym "HPFH", "Hereditary Persistence of Foetal Haemoglobin" ; a owl:Class ; rdfs:comment "This is a benign condition." ; rdfs:label "Hereditary Persistence of Fetal Hemoglobin" ; rdfs:subClassOf obo:SCDO_0007192, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000235 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0006860 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C35447 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:HP_0011904 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ] . obo:NCIT_C131682 obo:IAO_0000115 "A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles." ; obo:SCDO_0000340 obo:NCIT_C131682 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000549" ; oboInOwl:hasDbXref "NCIT:C131682" ; oboInOwl:hasExactSynonym "Hb SS Disease", "Hb SS-Disease", "Hemoglobin SS Disease", "Homozygous Sickle Cell Disease", "SCA", "SS and S/Beta-Zero Thalassemia", "Severe SCD", "Sickle Cell Anemia", "Sickle Cell Disease SS", "Sickle Cell Hemoglobin S Disease", "Sickle Cell-SS Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-SS" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000106, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000242 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:ARO_0000006 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:DOID_0060181 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:DOID_2326 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:DOID_813 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000084 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000097 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000822 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000823 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001269 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001394 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001406 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001635 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001658 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001873 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001875 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001878 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001889 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001896 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001974 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0002090 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0002204 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0002240 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0003158 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0003265 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0004756 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0004870 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0011106 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0011950 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0012330 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0012532 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0012574 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0012735 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0030243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0100749 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C102531 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C124059 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C128326 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C27088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C28516 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C34465 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C35146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C35152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C35372 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C35447 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C50791 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C78598 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C95437 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C96239 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C99042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C99063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000228 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000508 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000685 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000851 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000943 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0001067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0001135 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0001229 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0001511 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0002039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0002106 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0004187 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0004576 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0004829 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0004836 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0004847 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0004888 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0005167 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0005191 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006000 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006429 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006461 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006847 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006905 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006909 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0007161 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0008037 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0008625 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0008937 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0009117 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0009350 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0009445 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0009664 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_1000376 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C133543 obo:IAO_0000115 "A humanized monoclonal immunoglobulin G1 anti-P-selectin antibody with vaso-protective and anti-vaso-occlusive properties. Upon administration, crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand-1 (PSGL-1; SELPLG) on neutrophils and monocytes. P-selectin, a glycoprotein that functions as a cell adhesion molecule (CAM), translocates to the surface of activated endothelial cells and platelets, upon stimulation, where it binds to its ligand and mediates the rolling of platelets and neutrophils on activated endothelial cells. Therefore, blockade of p-selectin may inhibit platelet aggregation, maintain blood flow and minimize sickle cell-related pain crises (SCPC)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000380" ; dc:source , ; oboInOwl:hasDbXref "NCIT:C133543" ; oboInOwl:hasExactSynonym "Adakveo", "SEG101", "SelG1" ; a owl:Class ; rdfs:label "Crizanlizumab" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0000922 . obo:NCIT_C141366 obo:IAO_0000115 "A rare autosomal recessive hemoglobinopathy, caused by the presence of two deltabeta globin fusion chains, which occurs due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis." ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000538" ; oboInOwl:hasDbXref "NCIT:C141366" ; oboInOwl:hasExactSynonym "Hb Lepore", "Hb Lepore Syndrome", "Homozygous Hb Lepore", "Homozygous Hemoglobin Lepore" ; a owl:Class ; rdfs:label "Hemoglobin Lepore Syndrome" ; rdfs:subClassOf obo:SCDO_0000343, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CHMO_0001009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000666 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000209 ] . obo:NCIT_C142494 obo:IAO_0000115 "To maintain data by placing the data, or a copy of the data, onto an electronically accessible device for preservation (either in plain-text or encrypted format)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000420" ; oboInOwl:hasDbXref "NCIT:C142494" ; a owl:Class ; rdfs:label "Data Storage" ; rdfs:subClassOf obo:SCDO_0006339 . obo:NCIT_C142541 obo:IAO_0000115 "An independent group that comprises medical, scientific, and non-scientific members, and is tasked with the continuing review and approval of research, including clinical trials, with respect to the protocols, methods, and informed consent process to ensure the protection of the rights, safety, and wellbeing of participants." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009748" ; oboInOwl:hasDbXref "NCIT:C142541" ; oboInOwl:hasExactSynonym "Ethics Committee", "Human Subject Protection Committee", "REC", "Research Ethics Committee" ; a owl:Class ; rdfs:label "Research Ethics Committee" ; rdfs:subClassOf obo:SCDO_1000430 . obo:NCIT_C142664 obo:IAO_0000115 "The interval of time during which subjects are to be enrolled in a clinical study." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000400" ; oboInOwl:hasDbXref "NCIT:C142664" ; a owl:Class ; rdfs:label "Recruitment Period" ; rdfs:subClassOf obo:SCDO_0300005 . obo:NCIT_C152089 obo:IAO_0000115 "An orally bioavailable modulator and stabilizer of sickle cell hemoglobin (HbS), with potential use in the treatment of sickle cell disease (SCD). Upon administration, voxelotor targets and covalently binds to the N-terminal valine of the alpha chain of HbS. This stabilizes HbS, thereby improving oxygen binding affinity. The binding of voxelotor to HbS prevents HbS polymerization, reduces sickling, decreases red blood cell (RBC) damage and increases the half-life of RBCs. This improves blood flow and decreases hemolytic anemia." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000381" ; oboInOwl:hasDbXref "NCIT:C152089" ; oboInOwl:hasExactSynonym "GBT-440", "GBT440", "Oxbryta" ; a owl:Class ; rdfs:comment "Is an accepted therapy for adults and pediatric patients 12 years of age and older with sickle cell disease." ; rdfs:label "Voxelotor" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0000922 . obo:NCIT_C15238 obo:IAO_0000115 "Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15238" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001344" ; oboInOwl:hasDbXref "NCIT:C15238" ; oboInOwl:hasExactSynonym "DNA Therapy" ; a owl:Class ; rdfs:label "Gene Therapy" ; rdfs:subClassOf obo:SCDO_0000301, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:DOID_4 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000518 ] . obo:NCIT_C15320 obo:IAO_0000115 "A plan detailing how a study will be performed in order to represent the phenomenon under examination, to answer the research questions that have been asked, and defining the methods of data analysis. Study design is driven by research hypothesis being posed, study subject/population/sample available, logistics/resources: technology, support, networking, collaborative support, etc." ; obo:SCDO_0000303 "Review current sub-classes in light of and include relevant classes from \"EDDA Study Designs Taxonomy\" to be added as sub-classes." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001115" ; oboInOwl:hasDbXref "NCIT:C15320" ; oboInOwl:hasExactSynonym "Experiment Design", "Experimental Design", "Research Design", "STYPE" ; a owl:Class ; rdfs:label "Study Design" ; rdfs:subClassOf obo:SCDO_0300005 . obo:NCIT_C154481 obo:IAO_0000115 "A patient-reported outcome measurement system designed to evaluate and monitor the physical, mental, and social well-being of adults with sickle cell disease." ; obo:SCDO_0000340 ; obo:SCDO_0000470 "Cross-cultural adaptation underway in Brazil. ASCQ-Me's development using modern measurement theory facilitates cross cultural adaptation." ; obo:SCDO_0000479 "PhenX protocol: Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me) #820201" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic Patients (Adults with SCD)" ; obo:SCDO_0000484 "Spanish; Portuguese" ; obo:SCDO_0000486 "This measure can be used to track health status and treatment outcomes and understand the health care requirements of patients with chronic conditions, such as sickle cell disease (SCD)." ; obo:SCDO_0001033 "Rigor in development, using modern measurement theory and aligned with PROMIS measurement development." ; obo:SCDO_0001222 "18 years and older" ; obo:SCDO_0001335 "no" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000027" ; dc:source , "Keller SD, Yang M, Treadwell MJ, Werner EM, Hassell KL (2014).Patient reports of health outcome for adults living with sickle cell disease: development and testing of the ASCQ-Me item banks. Health and Quality of Life Outcomes,12,125." ; oboInOwl:hasDbXref "NCIT:C154481" ; oboInOwl:hasExactSynonym "ASCQ-Me", "Adult Sickle Cell Quality of Life Measurement Information System", "Adult Sickle Cell Quality-of-Life Measurement Information System" ; a owl:Class ; rdfs:comment "It includes questions that enable adults with SCD to describe their functioning and well-being. Its measures are available as 5 item short forms or can be administered as computer adaptive tests. Measures include: Pain Impact; Stiffness Impact (5-item short form); Sleep Impact; Social Functioning Impact; Emotional Impact; Pain Episodes; and Pain Frequency." ; rdfs:label "Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)" ; rdfs:subClassOf obo:SCDO_0000952, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:NCIT_C154865 obo:IAO_0000115 "An evaluation of the perfusion of blood through the brain." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000204" ; oboInOwl:hasDbXref "NCIT:C154865" ; oboInOwl:hasExactSynonym "Cerebral Blood Flow Assessment", "Cerebral Blood Flow Measurement", "Stroke Risk Test" ; a owl:Class ; rdfs:label "Cerebral Blood Flow Assay" ; rdfs:subClassOf obo:SCDO_0000208, obo:SCDO_1000316 . obo:NCIT_C155310 obo:IAO_0000115 "A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin D mutations. Patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin SS disease." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001060" ; oboInOwl:hasDbXref "NCIT:C155310" ; oboInOwl:hasExactSynonym "Haemoglobin S-D Disease", "Hb SD-Disease", "Hemoglobin S-D Disease", "Hemoglobin Sickle D Disease", "Sickle Cell Disease SD", "Sickle Cell Hemoglobin D Disease", "Sickle Cell-Haemoglobin D Disease", "Sickle Cell-Hemoglobin D Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-SD" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000163, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000113 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C15238 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000771 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001329 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0008888 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000108 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000109 ] . obo:NCIT_C155312 obo:IAO_0000115 "A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present." ; obo:SCDO_0000340 ; obo:SCDO_0000662 "Restricive lung disease often associated with chest pain and hypoxemia. May also be associated with pulmonary hypertension." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001046" ; dc:source "Powars et al 1988 Medicine (Baltimore), Knight-Madden et al 2010 Lung." ; oboInOwl:hasDbXref "NCIT:C155312" ; oboInOwl:hasExactSynonym "Sickle Cell Chronic Restrictive Lung Disease" ; a owl:Class ; rdfs:label "Sickle Cell Chronic Lung Disease" ; rdfs:subClassOf obo:SCDO_0000232, obo:SCDO_0000895, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000942 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C155932 obo:IAO_0000115 "A clinician-assessed rating of psychological and social functioning in children ages six to seventeen that was developed by Shaffer et al. in 1983. The numerical scale, which is an adaptation of the adult Global Assessment Scale (GAS) developed by Endicott et al in 1976, is scored from 0 to 100 based on behaviors and life situations that are applicable to children." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Global Mental Status Screener - Older Children and Adolescents #130703" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000334" ; dc:source ; oboInOwl:hasDbXref "NCIT:C155932" ; oboInOwl:hasExactSynonym "CGAS", "Children’s Global Assessment Scale", "Children’s Global Assessment Scale (CGAS)" ; a owl:Class ; rdfs:label "Global Mental Status Screener - Older Children and Adolescents" ; rdfs:subClassOf obo:SCDO_0000455 . obo:NCIT_C156541 obo:IAO_0000115 "A person who is separated from their spouse, whether or not there is a legal arrangement." ; obo:SCDO_0000340 obo:NCIT_C156541 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000677" ; oboInOwl:hasDbXref "NCIT:C156541" ; a owl:Class ; rdfs:label "Separated" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C15709 obo:IAO_0000115 "The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder." ; obo:SCDO_0000303 """Note: \"Genetic Test\" is a SNOMED CT term. Include NCIT's \"Presymptomatic Testing\" as a sub-class?""" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15709" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000449" ; oboInOwl:hasDbXref "NCIT:C15709" ; oboInOwl:hasExactSynonym "Genetic Analysis", "Genetic Examination", "Genetic Test" ; a owl:Class ; rdfs:label "Genetic Testing" ; rdfs:subClassOf obo:SCDO_0000448 . obo:NCIT_C15900 obo:IAO_0000115 "Therapy dealing with lifestyle management and includes: behavioral and dietary modifications, exercise, stress management, and addiction control. This therapy must be used as major adjunct to 'standard care' or be applied as alternative treatment to conventional medicine practices." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000006" ; oboInOwl:hasDbXref "NCIT:C15900" ; a owl:Class ; rdfs:label "Lifestyle Therapy" ; rdfs:subClassOf obo:SCDO_0001152, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000819 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002870 ] . obo:NCIT_C1643 obo:IAO_0000115 "An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C1643&jump_to_nav=true" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000915" ; oboInOwl:hasDbXref "NCIT:C1643" ; oboInOwl:hasExactSynonym "PPSV", "Pneumococcal Polysaccharide Vaccine", "Pneumococcal Polyvalent Vaccine" ; a owl:Class ; rdfs:label "Polyvalent Pneumococcal Vaccine" ; rdfs:subClassOf obo:VO_0000675 . obo:NCIT_C164339 obo:IAO_0000115 "The date on which a diagnosis of disease was made." ; obo:SCDO_0000340 obo:NCIT_C164339 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000557" ; oboInOwl:hasDbXref "NCIT:C164339" ; a owl:Class ; rdfs:label "Date of Diagnosis" ; rdfs:subClassOf obo:SCDO_1000538 . obo:NCIT_C16453 obo:IAO_0000115 "A set of people with some shared element. The substance of shared element varies widely, from geography to a situation to interest to lives and values. The term is widely used to evoke sense of collectivity." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000266" ; oboInOwl:hasDbXref "NCIT:C16453" ; a owl:Class ; rdfs:label "Community" ; rdfs:subClassOf obo:SCDO_0001082 . obo:NCIT_C16495 obo:IAO_0000115 "The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000468" ; oboInOwl:hasDbXref "NCIT:C16495" ; oboInOwl:hasExactSynonym "Demographic Factors", "Demographics", "Demography", "Population Studies / Demography" ; a owl:Class ; rdfs:label "Demographic Factor" ; rdfs:subClassOf obo:NCIT_C19332 . obo:NCIT_C16564 obo:IAO_0000115 "A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease." ; obo:SCDO_0000303 "Include other Ethnic groups that are sub-classes of \"Ethnic Group\" in ERO." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16564" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001298" ; oboInOwl:hasDbXref "NCIT:C16564" ; oboInOwl:hasExactSynonym "Ethnic Origin", "Ethnic Origins", "Ethnicity" ; a owl:Class ; rdfs:label "Ethnic Group" ; rdfs:subClassOf obo:SCDO_0001551, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ] . obo:NCIT_C16567 obo:IAO_0000115 "Activity that requires physical or mental exertion, especially when performed to develop or maintain fitness." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001305" ; oboInOwl:hasDbXref "NCIT:C16567" ; a owl:Class ; rdfs:label "Exercise" ; rdfs:subClassOf obo:NCIT_C15900, obo:SCDO_0000487, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000842 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000855 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000938 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000939 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001382 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002076 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002808 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003611 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001168 ] . obo:NCIT_C16576 obo:IAO_0000115 "A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both." ; obo:SCDO_0000340 obo:NCIT_C16576 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000560" ; oboInOwl:hasDbXref "NCIT:C16576" ; a owl:Class ; rdfs:label "Female" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C16612 obo:IAO_0000115 "A functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000359" ; oboInOwl:hasDbXref "NCIT:C16612" ; a owl:Class ; rdfs:label "Gene" ; rdfs:subClassOf obo:SCDO_0005722 . obo:NCIT_C16632 obo:IAO_0000115 "Any demarcated area of the Earth; may be determined by both natural and human boundaries." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000367" ; oboInOwl:hasDbXref "NCIT:C16632" ; oboInOwl:hasExactSynonym "Geographic Location", "Geographic Region" ; a owl:Class ; rdfs:label "Geographic Area" ; rdfs:subClassOf obo:NCIT_C19332 . obo:NCIT_C16676 obo:IAO_0000115 "The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb." ; obo:SCDO_0000340 obo:NCIT_C16676 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009453" ; oboInOwl:hasDbXref "NCIT:C16676" ; oboInOwl:hasExactSynonym "Hb", "Hgb" ; a owl:Class ; rdfs:label "Hemoglobin" ; rdfs:subClassOf obo:NCIT_C26548 . obo:NCIT_C16723 obo:IAO_0000115 "Laboratory test involving interaction of antigens with specific antibodies." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000617" ; oboInOwl:hasDbXref "NCIT:C16723" ; oboInOwl:hasExactSynonym "Immunoassay", "Immunological Laboratory Method", "Immunology Test" ; a owl:Class ; rdfs:label "Immunological Assay" ; rdfs:subClassOf obo:SCDO_0000120 . obo:NCIT_C16779 obo:IAO_0000115 "A systematic means of communicating by the use of sounds, symbols, or gestures." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C16779" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005364" ; oboInOwl:hasDbXref "NCIT:C16779" ; a owl:Class ; rdfs:label "Language" ; rdfs:subClassOf obo:SCDO_0001551 . obo:NCIT_C16809 obo:IAO_0000115 "Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16809" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000708" ; oboInOwl:hasDbXref "NCIT:C16809" ; oboInOwl:hasExactSynonym "MIR Scan", "MRI", "MRT", "Magnetic Resonance Imaging Scan", "Magnetic Resonance Tomography", "NMR Imaging", "NMRI", "Nuclear Magnetic Resonance Imaging" ; a owl:Class ; rdfs:label "Magnetic Resonance Imaging" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C168823 obo:IAO_0000115 "The year when a diagnosis was assigned to an individual's condition." ; obo:SCDO_0000340 obo:NCIT_C168823 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000567" ; oboInOwl:hasDbXref "NCIT:C168823" ; a owl:Class ; rdfs:label "Year of Diagnosis" ; rdfs:subClassOf obo:SCDO_1000538 . obo:NCIT_C17004 obo:IAO_0000115 "The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site to large nucleotide sequences visible at a chromosomal level." ; obo:SCDO_0000340 obo:NCIT_C17004 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004047" ; oboInOwl:hasDbXref "NCIT:C17004" ; a owl:Class ; rdfs:label "Genetic Polymorphism" ; rdfs:subClassOf obo:SCDO_0001369 . obo:NCIT_C17047 obo:IAO_0000115 "The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000949" ; oboInOwl:hasDbXref "NCIT:C17047" ; oboInOwl:hasExactSynonym "Health Related Quality of Life", "QOL" ; a owl:Class ; rdfs:label "Quality of Life" ; rdfs:subClassOf obo:SCDO_0000950, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:DOID_4 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000746 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000900 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000948 ] . obo:NCIT_C17049 obo:IAO_0000115 "An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution." ; obo:SCDO_0000303 """Different relevant racial groups need to be recorded. Perhaps as sub-classes of this class? The PhenX protocol is U.S. specific. Is there one relevant to the African setting?""" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17049" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000962" ; oboInOwl:hasDbXref "NCIT:C17049" ; oboInOwl:hasExactSynonym "Racial Group" ; a owl:Class ; rdfs:label "Race" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ] . obo:NCIT_C17230 obo:IAO_0000115 "A technique in which high-frequency sound waves are bounced off internal organs and the echo pattern is converted into a 2 dimensional picture of the structures beneath the transducer." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17230" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000614" ; oboInOwl:hasDbXref "NCIT:C17230" ; oboInOwl:hasExactSynonym "Immaging by Ultrasonography", "Ultrasonography", "Ultrasound", "Ultrasound Imaging" ; a owl:Class ; rdfs:label "Ultrasound Test" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:OBI_0001098 ] . obo:NCIT_C17241 obo:IAO_0000115 "Laboratory analysis of urine, commonly used to aid in the diagnosis of disease or to detect the presence of a specific substance. It involves examination of the urine by physical or chemical means as well as microscopic examination that helps to screen for urinary tract infections, renal disease, and diseases of other organs, that result in abnormal metabolites (break-down products) appearing in the urine." ; obo:SCDO_0000303 "Other urine tests to be added as sub-classes? There are many in the NCIT." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001216" ; oboInOwl:hasDbXref "NCIT:C17241" ; oboInOwl:hasExactSynonym "Urinalysis", "Urine Analysis" ; a owl:Class ; rdfs:label "Urine Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:NCIT_C173396 obo:IAO_0000115 "The rate of blood flow through the cerebral arteries." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000205" ; oboInOwl:hasDbXref "NCIT:C173396" ; oboInOwl:hasExactSynonym "CBF Velocity", "CBFV", "Transcranial Doppler Velocity" ; a owl:Class ; rdfs:label "Cerebral Blood Flow Velocity" ; rdfs:subClassOf obo:SCDO_0000213, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001166 ] . obo:NCIT_C17357 obo:IAO_0000115 "The assemblage of properties that distinguish people on the basis of the societal roles expected for the two sexes." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001341" ; oboInOwl:hasDbXref "NCIT:C17357" ; a owl:Class ; rdfs:label "Gender" ; rdfs:subClassOf obo:NCIT_C16495 . obo:NCIT_C17655 obo:IAO_0000115 "An account of all reproductive events and problems a person has experienced. An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000346" ; oboInOwl:hasDbXref "NCIT:C17655" ; a owl:Class ; rdfs:label "Reproductive History" ; rdfs:subClassOf obo:NCIT_C18772 . obo:NCIT_C17873 obo:IAO_0000115 "Having to do with the physical, psychological, cognitive, and social consequences of disease, including stigmatization of persons affected." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17873" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000939" ; oboInOwl:hasDbXref "NCIT:C17873" ; oboInOwl:hasExactSynonym "Psychosocial Effects", "Psychosocial Effects/Treatment" ; a owl:Class ; rdfs:label "Psychosocial Effect" ; rdfs:subClassOf obo:SCDO_0000746 . obo:NCIT_C18133 obo:IAO_0000115 "A single base pair substitution that alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position. Some missense mutations will alter the function of the protein." ; obo:SCDO_0000340 obo:NCIT_C18133 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004314" ; oboInOwl:hasDbXref "NCIT:C18133" ; a owl:Class ; rdfs:label "Missense Mutation" ; rdfs:subClassOf obo:NCIT_C62200 . obo:NCIT_C18772 obo:IAO_0000115 "A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies." ; obo:SCDO_0000303 "Sub-classes in NCIT to be added here." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C18772" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000891" ; oboInOwl:hasDbXref "NCIT:C18772" ; oboInOwl:hasExactSynonym "General Medical History", "Medical History", "PMH", "Past Medical History" ; a owl:Class ; rdfs:label "Personal Medical History" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_1000157 . obo:NCIT_C19228 obo:IAO_0000115 "An instrument used to measure an event involving emission, absorption, or refraction of light." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C19228" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000837" ; oboInOwl:hasDbXref "NCIT:C19228" ; a owl:Class ; rdfs:label "Optical Instrument" ; rdfs:subClassOf obo:OBI_0400169 . obo:NCIT_C19296 obo:IAO_0000115 "Any rearrangement to the genomic content that results in the loss of one or more nucleotides of DNA. Deletions are generally irreversible rearrangements. They may alter the reading frame of a gene, or may result in loss of large chromosomal regions." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C19296" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001371" ; oboInOwl:hasDbXref "NCIT:C19296" ; oboInOwl:hasExactSynonym "Deletion Abnormality" ; a owl:Class ; rdfs:label "Deletion Mutation" ; rdfs:subClassOf obo:IDOMAL_50000026, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C26548 ] . obo:NCIT_C19332 obo:IAO_0000115 "The distinguishing qualities or prominent aspects of an individual person." ; obo:SCDO_0000303 "Populate this class with demographic terms from PhenX and elsewhere. Some terms will be duplicated in QoL. -- -- Add these from PhenX?: -- - Acculturation -- - Residential History -- -- Also look at other sub-classes in NCIT." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C19332" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000890" ; oboInOwl:hasDbXref "NCIT:C19332" ; oboInOwl:hasExactSynonym "Subject Characteristics" ; a owl:Class ; rdfs:label "Personal Attribute" ; rdfs:subClassOf obo:SCDO_0001000 . obo:NCIT_C19771 obo:IAO_0000115 "Analysis of the RNA expression pattern in a tissue sample using molecular techniques." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000768" ; oboInOwl:hasDbXref "NCIT:C19771" ; oboInOwl:hasExactSynonym "Expression Profiling", "Molecular Fingerprinting", "Molecular Profiling" ; a owl:Class ; rdfs:label "Molecular Profiling Assay" ; rdfs:subClassOf obo:SCDO_0000082 . obo:NCIT_C20197 obo:IAO_0000115 "A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both." ; obo:SCDO_0000340 obo:NCIT_C20197 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000559" ; oboInOwl:hasDbXref "NCIT:C20197" ; a owl:Class ; rdfs:label "Male" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C20629 obo:IAO_0000115 "A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected." ; obo:SCDO_0000340 obo:NCIT_C20629 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005439" ; oboInOwl:hasDbXref "NCIT:C20629" ; oboInOwl:hasExactSynonym "Exon Synonymous Mutation", "Exonic Synonymous Mutation", "Synonymous Mutation" ; a owl:Class ; rdfs:label "Silent Mutation" ; rdfs:subClassOf obo:NCIT_C62200 . obo:NCIT_C20711 obo:IAO_0000115 "This gene plays a role in transcriptional regulation and is involved in several signal transduction pathways." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000393" ; oboInOwl:hasDbXref "NCIT:C20711" ; oboInOwl:hasExactSynonym "SP1", "Sp1 Transcription Factor Gene" ; a owl:Class ; rdfs:label "SP1 Gene" ; rdfs:subClassOf obo:NCIT_C16612 . obo:NCIT_C25150 obo:IAO_0000115 "How long something has existed; elapsed time since birth." ; obo:SCDO_0000303 "Could add many sub-classes of \"Age\" from NCIT." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C25150" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000030" ; oboInOwl:hasDbXref "NCIT:C25150" ; oboInOwl:hasExactSynonym "Aged", "Chronological Age", "Postnatal Age" ; a owl:Class ; rdfs:label "Age" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_1000157 . obo:NCIT_C25191 obo:IAO_0000115 "A word or group of words indicating the identity of a person usually consisting of a first (personal) name and a last (family) name with an optional middle name. In some cultural traditions the family name comes first." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000859" ; oboInOwl:hasDbXref "NCIT:C25191" ; oboInOwl:hasExactSynonym "Contact Name", "Individual's Name", "Name", "Name of Person", "Person.name" ; a owl:Class ; rdfs:label "Person Name" ; rdfs:subClassOf obo:NCIT_C19332 . obo:NCIT_C25298 obo:IAO_0000115 "The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart." ; obo:SCDO_0000340 obo:NCIT_C25298 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000892" ; oboInOwl:hasDbXref "NCIT:C25298" ; oboInOwl:hasExactSynonym "SYSBP", "Systolic Pressure", "systolic bp" ; a owl:Class ; rdfs:label "Systolic Blood Pressure" ; rdfs:subClassOf obo:CMO_0000003 . obo:NCIT_C25299 obo:IAO_0000115 "The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling." ; obo:SCDO_0000340 obo:NCIT_C25299 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000739 6 ; obo:SCDO_1000910 "SCDO:1000893" ; oboInOwl:hasDbXref "NCIT:C25299" ; oboInOwl:hasExactSynonym "DIABP", "Diastolic Pressure" ; a owl:Class ; rdfs:label "Diastolic Blood Pressure" ; rdfs:subClassOf obo:CMO_0000003 . obo:NCIT_C25460 obo:IAO_0000115 "Permission to do something." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C25460" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001466" ; oboInOwl:hasDbXref "NCIT:C25460" ; a owl:Class ; rdfs:label "Consent" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_0007597 . obo:NCIT_C25464 obo:IAO_0000115 "A collective generic term that refers here to a wide variety of dependencies, areas of special sovereignty, uninhabited islands, and other entities in addition to the traditional countries or independent states." ; obo:IAO_0100001 obo:SCDO_0000792 ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C25464" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004140" ; oboInOwl:hasDbXref "NCIT:C25464" ; a owl:Class ; rdfs:label "deprecated Country" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:NCIT_C25474 obo:IAO_0000115 "A collection or single item of factual or reported information, derived from measurement or research, from which conclusions may be drawn." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006670" ; oboInOwl:hasDbXref "NCIT:C25474" ; a owl:Class ; rdfs:label "Data" ; rdfs:subClassOf obo:NCIT_C19332 . obo:NCIT_C258 obo:IAO_0000115 "Substances naturally produced by microorganisms or their derivatives that selectively target microorganisms not humans. Antibiotics kill or inhibit the growth of microorganisms by targeting components of the microbial cell absent from human cells, including bacterial cell walls, cell membrane, and 30S or 50S ribosomal subunits. These substances are used in the treatment of bacterial and other microbial infections." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C258" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000059" ; oboInOwl:hasDbXref "NCIT:C258" ; oboInOwl:hasExactSynonym "Antibiotic Agents", "Antibiotic Drug", "Antibiotic Drugs", "Antibiotics", "Antimicrobial", "Antimicrobial Agent" ; a owl:Class ; rdfs:label "Antibiotic" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000132 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000388 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000999 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001061 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001287 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0006689 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0008404 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0030049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0030127 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0100806 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:MP_0002412 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C95504 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000812 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000840 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001073 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C26548 obo:IAO_0000115 "A protein, RNA or a complex that contains proteins and/or RNA." ; obo:SCDO_0000303 "If additional gene products are included in the future, they can be categorised according to those below this term in the \"National Cancer Institute Thesaurus\" (NCIT)" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C26548" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001343" ; oboInOwl:hasDbXref "NCIT:C26548" ; oboInOwl:hasExactSynonym "Genome Encoded Entity" ; a owl:Class ; rdfs:label "Gene Product" ; rdfs:subClassOf obo:SCDO_0001000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:IDOMAL_50000026 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:NCIT_C19296 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:NCIT_C62200 ] . obo:NCIT_C26702 obo:IAO_0000115 "Lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Causes include peripheral nerve disorders, posterior column injuries, cerebral and cerebellar disorders, basal ganglia disorders, and thalamic disorders." ; obo:SCDO_0000303 "Perhaps add \"Cerebellar Ataxia\" subclass?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000087" ; oboInOwl:hasDbXref "NCIT:C26702" ; a owl:Class ; rdfs:label "Ataxia" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OGMS_0000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000822 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C27088 obo:IAO_0000115 "Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003118" ; oboInOwl:hasDbXref "NCIT:C27088" ; oboInOwl:hasExactSynonym "High Blood Bilirubin Levels" ; a owl:Class ; rdfs:label "Hyperbilirubinemia" ; rdfs:subClassOf obo:HP_0032180 . obo:NCIT_C27222 obo:IAO_0000115 "A balloon type pouch or bulge in the wall of a cerebral blood vessel." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000202" ; oboInOwl:hasDbXref "NCIT:C27222" ; oboInOwl:hasExactSynonym "Brain Aneurysm", "Cerebral Artery Aneurysm", "Dilatation of the Cerebral Artery", "Intracranial Aneurysm" ; a owl:Class ; rdfs:label "Cerebral Aneurysm" ; rdfs:subClassOf obo:HP_0002060, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:NCIT_C28407 obo:IAO_0000115 "System of classification based on nation from which a person originates, regardless of the nation in which he/she currently resides." ; obo:SCDO_0000303 "Include list of nations below." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C28407" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000792" ; oboInOwl:hasDbXref "NCIT:C28407" ; oboInOwl:hasExactSynonym "Birth Country", "Country of Birth", "Country of Origin" ; a owl:Class ; rdfs:label "National Origin" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0001090 . obo:NCIT_C28421 obo:IAO_0000115 "The totality of characteristics of reproductive structure, functions, phenotype, and genotype, differentiating the male from the female organism." ; obo:SCDO_0000340 obo:NCIT_C28421 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000671" ; oboInOwl:hasDbXref "NCIT:C28421" ; oboInOwl:hasExactSynonym "Participant Sex", "Participant's Sex", "Respondent's Sex", "Sex of Participant" ; a owl:Class ; rdfs:label "Sex" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0000122 . obo:NCIT_C28516 obo:IAO_0000115 "A severe acute inflammatory response affecting the hands and feet of individuals with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and finally infarction of the distal portions of the extremities. Clinical signs of pain, swelling and tenderness of digits usually begin in early childhood and may be the initial manifestations of sickle cell anemia. Clinical course is self-limited with instances typically lasting a few weeks and occurring during sickling crises. An initial episode before the age of 1 strongly correlates with a more severe disease course." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C28516" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000477" ; oboInOwl:hasDbXref "NCIT:C28516" ; a owl:Class ; rdfs:label "Sickle Cell Dactylitis" ; rdfs:subClassOf obo:HP_0002715, obo:SCDO_0001023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0008623 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C2890 obo:IAO_0000115 "An acute infectious disorder caused by gram positive or gram negative bacteria. Representative examples include pneumococcal, streptococcal, salmonella and meningeal infections." ; obo:SCDO_0000303 "Perhaps use as Disease Modifier?" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2890" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000100" ; oboInOwl:hasDbXref "NCIT:C2890" ; a owl:Class ; rdfs:label "Bacterial Infection" ; rdfs:subClassOf obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C2905 obo:IAO_0000115 "Increase in the number of hematopoietic cells in the bone marrow. It may involve all or individual hematopoietic cell lines." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C2905" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007438" ; oboInOwl:hasDbXref "NCIT:C2905" ; oboInOwl:hasExactSynonym "Hyperplasia of Bone Marrow", "Marrow Hyperplasia" ; a owl:Class ; rdfs:label "Bone Marrow Hyperplasia" ; rdfs:subClassOf obo:HP_0001871, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ] . obo:NCIT_C29091 obo:IAO_0000115 "A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C29091" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008062" ; oboInOwl:hasDbXref "NCIT:C29091" ; oboInOwl:hasExactSynonym "ENGERIX-B", "Hepatitis B Vaccine (Recombinant)", "RECOMBIVAX HB", "Recombinant Hepatitis B Vaccine" ; a owl:Class ; rdfs:label "Hepatitis B Vaccine" ; rdfs:subClassOf obo:VO_0000001, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:NCIT_C29107 obo:IAO_0000115 "A sterile liquid preparation infused into a vein. IV fluid is prescribed as a replacement of fluid, electrolytes, calories, vitamins, and other nutritional substances. In addition, IV fluids are used to administer blood products and medications such as chemotherapy. Examples of IV fluids include Normal Saline, Ringers Solution, and Lactated Ringers Solution." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C29107" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005247" ; oboInOwl:hasDbXref "NCIT:C29107" ; oboInOwl:hasExactSynonym "Intravenous Fluid" ; a owl:Class ; rdfs:label "IV fluids" ; rdfs:subClassOf obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:NCIT_C2959 obo:IAO_0000115 "Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000384" ; oboInOwl:hasDbXref "NCIT:C2959" ; oboInOwl:hasExactSynonym "Complications", "Medical Complication" ; a owl:Class ; rdfs:label "Complication" ; rdfs:subClassOf obo:HP_0000118 . obo:NCIT_C29719 obo:IAO_0000115 "A record of an individual's background in regard to smoking tobacco. This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C29719" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001081" ; oboInOwl:hasDbXref "NCIT:C29719" ; oboInOwl:hasExactSynonym "Tobacco Smoking History" ; a owl:Class ; rdfs:label "Smoking History" ; rdfs:subClassOf obo:SCDO_0001120 . obo:NCIT_C30142 obo:IAO_0000115 "An account of all experiences related to the receipt of blood, WBC, platelets, and/or other blood components." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000569" ; oboInOwl:hasDbXref "NCIT:C30142" ; oboInOwl:hasExactSynonym "Transfusion History" ; a owl:Class ; rdfs:label "History of Transfusion" ; rdfs:subClassOf obo:NCIT_C18772 . obo:NCIT_C3245 obo:IAO_0000115 "An infection caused by a fungus." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000349" ; oboInOwl:hasDbXref "NCIT:C3245" ; a owl:Class ; rdfs:label "Fungal Infection" ; rdfs:subClassOf obo:IDO_0000586 . obo:NCIT_C3439 obo:IAO_0000115 "Any disease caused by a virus." ; obo:SCDO_0000303 """Perhaps use as Disease Modifier? Add these sub-classes: Hepatitis C Infection (term in NCIT) Hepatitis B Infection (term in NCIT) HIV Infection (term in NCIT)""" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C3439" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001233" ; oboInOwl:hasDbXref "NCIT:C3439" ; oboInOwl:hasExactSynonym "Viral Disease", "Virus Disease" ; a owl:Class ; rdfs:label "Viral Infection" ; rdfs:subClassOf obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C34465 obo:IAO_0000115 "An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C34465" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007856" ; oboInOwl:hasDbXref "NCIT:C34465" ; a owl:Class ; rdfs:label "Cholecystitis" ; rdfs:subClassOf obo:HP_0025031, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C34887 obo:IAO_0000115 "A sensation of discomfort secondary to surgery." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000451" ; oboInOwl:hasDbXref "NCIT:C34887" ; oboInOwl:hasExactSynonym "Perioperative Pain", "Post Surgery Pain", "Post-Operative Pain", "Postoperative Pain" ; a owl:Class ; rdfs:label "Peri-Operative Pain" ; rdfs:subClassOf obo:SCDO_0000851 . obo:NCIT_C34941 obo:IAO_0000115 "The co-occurrence of pregnancy and a disease. The disease may precede or follow conception and it may or may not have a deleterious effect on the pregnant woman or fetus." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000399" ; oboInOwl:hasDbXref "NCIT:C34941" ; oboInOwl:hasExactSynonym "Complication Related to Pregnancy" ; a owl:Class ; rdfs:label "Pregnancy Complication" ; rdfs:subClassOf obo:NCIT_C2959 . obo:NCIT_C35069 obo:IAO_0000115 "An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation." ; obo:SCDO_0000340 obo:NCIT_C35069 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001144" ; oboInOwl:hasDbXref "NCIT:C35069" ; a owl:Class ; rdfs:label "Thalassemia" ; rdfs:subClassOf obo:SCDO_0007192, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:NCIT_C35146 obo:IAO_0000115 "Cholecystitis that is persistent and long-standing." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C35146" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009201" ; oboInOwl:hasDbXref "NCIT:C35146" ; a owl:Class ; rdfs:label "Chronic Cholecystitis" ; rdfs:subClassOf obo:NCIT_C34465, obo:SCDO_0001334, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:NCIT_C35152 obo:IAO_0000115 "Acute inflammation of the gallbladder." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C35152" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008927" ; oboInOwl:hasDbXref "NCIT:C35152" ; a owl:Class ; rdfs:label "Acute Cholecystitis" ; rdfs:subClassOf obo:NCIT_C34465, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C35372 obo:IAO_0000115 "Acute infection of the bile ducts caused by bacteria ascending from the small intestine." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C35372" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008766" ; oboInOwl:hasDbXref "NCIT:C35372" ; a owl:Class ; rdfs:label "Ascending Cholangitis" ; rdfs:subClassOf obo:HP_0025031, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:NCIT_C35447 obo:IAO_0000115 "Necrotic changes in the bone tissue of the femoral head due to interruption of blood supply." ; obo:SCDO_0000303 "Add description. -- See HPO term \"Avascular necrosis of the capital femoral epiphysis\". -- -- Perhaps add \"Bone decompression by drilling\" to therapeutics and link to it with \"is treated with" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C35447" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000842" ; oboInOwl:hasDbXref "NCIT:C35447" ; oboInOwl:hasExactSynonym "Avascular Necrosis of Femoral Head", "Avascular Necrosis of the Capital Femoral Epiphysis", "Avascular Necrosis of the Femoral Head", "Avascular Necrosis of the Head of Femur", "ONFH" ; a owl:Class ; rdfs:label "Osteonecrosis of the Femoral Head" ; rdfs:subClassOf obo:HP_0010885, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C3671 obo:IAO_0000115 "Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000435" ; oboInOwl:hasDbXref "NCIT:C3671" ; oboInOwl:hasExactSynonym "Trauma", "Wound" ; a owl:Class ; rdfs:label "Injury" ; rdfs:subClassOf obo:HP_0000118 . obo:NCIT_C38060 obo:IAO_0000115 "A test performed by an ophthalmologist or optometrist assessing vision and ability to focus on and discern objects, as well as other tests and examinations pertaining to the eyes." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C38060" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001313" ; oboInOwl:hasDbXref "NCIT:C38060" ; oboInOwl:hasExactSynonym "Eye Exam" ; a owl:Class ; rdfs:label "Eye Examination" ; rdfs:subClassOf obo:SCDO_0000898 . obo:NCIT_C38085 obo:IAO_0000115 "A non-invasive method that provides estimates of arterial oxyhemoglobin saturation by utilizing selected wavelengths of light to determine the saturation of oxyhemoglobin." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000351" ; oboInOwl:hasDbXref "NCIT:C38085" ; a owl:Class ; rdfs:label "Pulse Oximetry" ; rdfs:subClassOf obo:SCDO_0000942 . obo:NCIT_C38141 obo:IAO_0000115 "An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C38141" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000911" ; oboInOwl:hasDbXref "NCIT:C38141" ; oboInOwl:hasExactSynonym "7 Valent PncOMPC Vaccine", "7-Valent PncOMPC Vaccine", "Heptavalent Pneumococcal Conjugate Vaccine", "PCV 7", "PCV7 Vaccine", "Pneumococcal 7-Valent Conjugate Vaccine (Diphtheria CRM197 Protein)", "Prevenar", "Prevnar", "Seven Valent Pneumococcal PS Meningococcal OMPC Conjugate Vaccine", "Seven-Valent Pneumococcal PS-Meningococcal OMPC Conjugate Vaccine" ; a owl:Class ; rdfs:label "Pneumococcal 7-Valent Conjugate Vaccine" ; rdfs:subClassOf obo:NCIT_C97123 . obo:NCIT_C3833 obo:IAO_0000115 "Without clinical signs or indications that raise the possibility of a particular disorder or dysfunction." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004802" ; oboInOwl:hasDbXref "NCIT:C3833" ; oboInOwl:hasExactSynonym "No Symptoms" ; a owl:Class ; rdfs:label "Asymptomatic" ; rdfs:subClassOf obo:OGMS_0000023 . obo:NCIT_C38698 obo:IAO_0000115 "An increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C38698" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002771" ; oboInOwl:hasDbXref "NCIT:C38698" ; oboInOwl:hasExactSynonym "Blood Hyperviscosity", "Hypercoagulability", "Thrombophilia" ; a owl:Class ; rdfs:label "Hyperviscosity" ; rdfs:subClassOf obo:HP_0001871, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C3890 obo:IAO_0000115 "A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). In SCD patients, this is considered as saturated oxygen < 95% on air." ; obo:SCDO_0000303 """Have merged the definition of hypoxia from NCIT and the Tanzanian Management Guidelines. Not sure if the SaO2 value is specific to SCD patients - please get a clinician to review. This is a symptom of acute chest syndrome.""" ; obo:SCDO_0000340 obo:NCIT_C3890, "SCD Management guidelines - Tanzania" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004183" ; oboInOwl:hasDbXref "NCIT:C3890" ; a owl:Class ; rdfs:label "Hypoxia" ; rdfs:subClassOf obo:HP_0002086, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C39547 obo:IAO_0000115 "The probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000156" ; oboInOwl:hasDbXref "NCIT:C39547" ; oboInOwl:hasExactSynonym "Clinical Efficacy" ; a owl:Class ; rdfs:label "Treatment Efficacy" ; rdfs:subClassOf obo:NCIT_C43646 . obo:NCIT_C39796 obo:IAO_0000115 "The philosophical study of moral values and rules. Ethics is a general term for what is often described as the \"science of morality\". The Western tradition of ethics is sometimes called moral philosophy. This is one of the three major branches of philosophy, alongside metaphysics and logic." ; obo:SCDO_0000340 , "http://purl.bioontology.org/ontology/MESH/D004989" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0300001" ; oboInOwl:hasDbXref "NCIT:C39796" ; oboInOwl:hasExactSynonym "Moral Philosophy", "Natural Law" ; a owl:Class ; rdfs:label "Ethics" ; rdfs:subClassOf obo:SCDO_0006339 . obo:NCIT_C40438 obo:IAO_0000115 "The BDI-II is the most widely used instrument for measuring depression. It consists of 21 items to assess the intensity of depression in clinical and normal patients. Each item is a list of four statements arranged in increasing severity about a particular symptom of depression, and rated on a scale of 0 to 3." ; obo:SCDO_0000340 "Beck A.T., Ward C. H., Mendelson M., Mock J., & Erbaugh J. (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic Patients" ; obo:SCDO_0000484 "Spanish" ; obo:SCDO_0001222 "13 years and older" ; obo:SCDO_0001335 "yes" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000103" ; oboInOwl:hasDbXref "NCIT:C40438" ; oboInOwl:hasExactSynonym "BDI-II", "Beck Depression Inventory", "Beck Depression Inventory-II" ; a owl:Class ; rdfs:label "Beck Depression Inventory-II (BDI-II)" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297 . obo:NCIT_C40978 obo:IAO_0000115 "A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network." ; obo:SCDO_0000340 obo:NCIT_C40978 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000881" ; oboInOwl:hasDbXref "NCIT:C40978" ; oboInOwl:hasExactSynonym "Phone", "Phone Number", "Telephone" ; a owl:Class ; rdfs:label "Telephone Number" ; rdfs:subClassOf obo:NCIT_C19332 . obo:NCIT_C41129 obo:IAO_0000115 "An area or portion of something with more or less definite boundaries designed or specified according to some established biological, administrative, economic, demographic, etc. criteria." ; obo:IAO_0100001 obo:SCDO_1000367 ; obo:SCDO_0000303 "It didn't have sense to have this term as a sub-class of \"Major Area\", which has also been deprecated." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C41129" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006934" ; oboInOwl:hasDbXref "NCIT:C41129" ; a owl:Class ; rdfs:label "deprecated Region" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:NCIT_C42559 obo:IAO_0000115 "A unit of temperature of the temperature scale designed so that the freezing point of water is 0 degrees and the boiling point is 100 degrees at standard atmospheric pressure. The current official definition of the Celsius sets 0.01 C to be at the triple point of water and a degree to be 1/273.16 of the difference in temperature between the triple point of water and absolute zero. One degree Celsius represents the same temperature difference as one Kelvin." ; obo:SCDO_0000340 obo:NCIT_C42559 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000713" ; oboInOwl:hasDbXref "NCIT:C42559" ; oboInOwl:hasExactSynonym "C", "Celsius", "Celsius Degree", "Celsius Temperature", "Degree C", "Degree Centigrade", "Degrees C", "Degrees Celsius" ; a owl:Class ; rdfs:label "Degree Celsius" ; rdfs:subClassOf obo:UO_0000005 . obo:NCIT_C43646 obo:IAO_0000115 "An association is a non-hierarchical, named relationship between a source and target concept that does not affect classification and is not inherited by child concepts during classification. Associations are bidirectional and have a stated inverse. Unlike roles, associations do not have a domain or range." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005031" ; oboInOwl:hasDbXref "NCIT:C43646" ; a owl:Class ; rdfs:label "Association" ; rdfs:subClassOf obo:SCDO_0001000 . obo:NCIT_C48660 obo:IAO_0000115 "Determination of a value is not relevant in the current context." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000770" ; oboInOwl:hasDbXref "NCIT:C48660" ; oboInOwl:hasExactSynonym "Not Applicable" ; a owl:Class ; rdfs:label "NA" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C49131 obo:IAO_0000115 "A diagnostic test used to examine and define microscopic tissue structure, composition, or etiology. The test results are often used by a clinician to diagnose disease or disordered function." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004740" ; oboInOwl:hasDbXref "NCIT:C49131" ; oboInOwl:hasExactSynonym "Histologic Test" ; a owl:Class ; rdfs:label "Diagnostic Histology Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:NCIT_C49674 obo:IAO_0000115 "The number of breaths (inhalation and exhalation) taken per minute time." ; obo:SCDO_0000340 obo:NCIT_C49674 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000716" ; oboInOwl:hasDbXref "NCIT:C49674" ; oboInOwl:hasExactSynonym "Breaths/Minute", "bpm", "breaths/min", "{BREATHS}/min", "{breaths}/min" ; a owl:Class ; rdfs:label "Breaths per Minute" ; rdfs:subClassOf obo:UO_0000280 . obo:NCIT_C50474 obo:IAO_0000115 "Abnormal decrease of rate of breathing." ; obo:SCDO_0000340 obo:NCIT_C50474 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000293" ; oboInOwl:hasDbXref "NCIT:C50474" ; oboInOwl:hasExactSynonym "Decreased Respiratory Rate" ; a owl:Class ; rdfs:label "Bradypnea" ; rdfs:subClassOf obo:HP_0002086 . obo:NCIT_C50767 obo:IAO_0000115 "Abnormal increase of rate of breathing." ; obo:SCDO_0000340 obo:NCIT_C50767 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000347" ; oboInOwl:hasDbXref "NCIT:C50767" ; oboInOwl:hasExactSynonym "Fast Breathing", "Increased Respiratory Rate" ; a owl:Class ; rdfs:label "Tachypnea" ; rdfs:subClassOf obo:HP_0002086 . obo:NCIT_C50791 obo:IAO_0000115 "A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C50791" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007744" ; oboInOwl:hasDbXref "NCIT:C50791" ; a owl:Class ; rdfs:label "Urinary Tract Infection" ; rdfs:subClassOf obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C51677 obo:IAO_0000115 "Removal of tissue from the liver for microscopic examination." ; obo:SCDO_0000303 "Use relevant object property to link to \"Elevated Hepatic Iron Concentration\"." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C51677" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000693" ; oboInOwl:hasDbXref "NCIT:C51677" ; a owl:Class ; rdfs:label "Liver Biopsy" ; rdfs:subClassOf obo:SCDO_0000082 . obo:NCIT_C51773 obo:IAO_0000115 "Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together." ; obo:SCDO_0000340 obo:NCIT_C51773 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000674" ; oboInOwl:hasDbXref "NCIT:C51773" ; oboInOwl:hasExactSynonym "Married Status" ; a owl:Class ; rdfs:label "Married" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C51774 obo:IAO_0000115 "Indicates a person who has never been married or whose marriages have been annulled." ; obo:SCDO_0000340 obo:NCIT_C51774 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000678" ; oboInOwl:hasDbXref "NCIT:C51774" ; oboInOwl:hasExactSynonym "Never Been Married/Annulled", "Never Married", "Never Married Status" ; a owl:Class ; rdfs:label "Never Been Married" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C51775 obo:IAO_0000115 "Indicates a person who is no longer married because of the death of his/her spouse and has not remarried." ; obo:SCDO_0000340 obo:NCIT_C51775 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000675" ; oboInOwl:hasDbXref "NCIT:C51775" ; oboInOwl:hasExactSynonym "Widowed Status" ; a owl:Class ; rdfs:label "Widowed" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C51776 obo:IAO_0000115 "Indicates a person whose marriage has been legally dissolved and has not remarried." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000676" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source obo:NCIT_C51776 ; oboInOwl:hasDbXref "NCIT:C51776" ; a owl:Class ; rdfs:label "Divorced" ; rdfs:subClassOf obo:NCIT_C91106 . obo:NCIT_C519 obo:IAO_0000115 "A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C519" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001259" ; oboInOwl:hasDbXref "NCIT:C519" ; oboInOwl:hasExactSynonym "Garamicin", "Garamycin", "Genoptic", "Genoptic S.O.P.", "Gentamycin", "Gentamycin Complex", "U-Gencin" ; a owl:Class ; rdfs:label "Gentamicin" ; rdfs:subClassOf obo:NCIT_C258, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:NCIT_C51993 obo:IAO_0000115 "Administration of antibiotics with the intent of preventing bacterial infection." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C51993" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006790" ; oboInOwl:hasDbXref "NCIT:C51993" ; a owl:Class ; rdfs:comment "Is recommended, particularly up to the age of 5 years, to prevent bacterial infections in SCD patients." ; rdfs:label "Antibiotic Prophylaxis" ; rdfs:subClassOf obo:SCDO_0000930, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:NCIT_C52009 obo:IAO_0000115 "A prenatal diagnostic procedure in which a small sample of amniotic fluid is removed from the uterus by a needle inserted into the abdomen. This procedure is used to detect various genetic abnormalities in the fetus and/or the sex of the fetus." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C52009" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000048" ; oboInOwl:hasDbXref "NCIT:C52009" ; oboInOwl:hasExactSynonym "Amniotic Fluid Testing" ; a owl:Class ; rdfs:label "Amniocentesis" ; rdfs:subClassOf obo:SCDO_0000919 . obo:NCIT_C561 obo:IAO_0000115 "A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000606" ; dc:source "http://www.drugbank.ca/drugs/DB01050" ; oboInOwl:hasDbXref "NCIT:C561" ; oboInOwl:hasExactSynonym "2-[4-(2-methylpropyl)phenyl]propanoic acid", "Advil", "Ibuprophen", "Motrin" ; a owl:Class ; rdfs:label "Ibuprofen" ; rdfs:subClassOf obo:CHEBI_35475, obo:CHEBI_35493, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002341 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C61797 obo:IAO_0000115 "A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000450" ; oboInOwl:hasDbXref "NCIT:C61797" ; a owl:Class ; rdfs:label "Ketamine" ; rdfs:subClassOf obo:CHEBI_23888 . obo:NCIT_C62005 obo:IAO_0000115 "A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity." ; obo:SCDO_0000303 "Used to treat neuropathic pain" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C62005" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004190" ; oboInOwl:hasDbXref "NCIT:C62005" ; a owl:Class ; rdfs:label "Amitriptyline" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000228 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:NCIT_C62198 obo:IAO_0000115 "A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein." ; obo:SCDO_0000340 obo:NCIT_C62198 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003789" ; oboInOwl:hasDbXref "NCIT:C62198" ; oboInOwl:hasExactSynonym "Premature Termination Abnormality", "Premature Termination Mutation" ; a owl:Class ; rdfs:label "Nonsense Mutation" ; rdfs:subClassOf obo:NCIT_C62200 . obo:NCIT_C62200 obo:IAO_0000115 "A small scale mutation caused by the substitution of a single nucleotide for another nucleotide." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C62200" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001372" ; oboInOwl:hasDbXref "NCIT:C62200" ; a owl:Class ; rdfs:label "Point Mutation" ; rdfs:subClassOf obo:IDOMAL_50000026, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C26548 ] . obo:NCIT_C63547 obo:IAO_0000115 "A way of denoting the collective genotype of a number of closely linked loci on a chromosome." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007716" ; oboInOwl:hasDbXref "NCIT:C63547" ; a owl:Class ; rdfs:label "Haplotype" ; rdfs:subClassOf obo:SCDO_0004061 . obo:NCIT_C64387 obo:IAO_0000115 "A unit of concentration (molarity unit) equal to one millimole of solute per liter of solution." ; obo:SCDO_0000340 obo:NCIT_C64387 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000899" ; oboInOwl:hasDbXref "NCIT:C64387" ; oboInOwl:hasExactSynonym "Millimolar", "mM", "mmol/L" ; a owl:Class ; rdfs:label "Millimole per Liter" ; rdfs:subClassOf obo:UO_0000051 . obo:NCIT_C64572 obo:IAO_0000115 "A metric unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one cubic meter. The concept also refers to the metric unit of mass density (volumic mass) defined as the density of a substance which mass equal to one gram occupies the volume of one cubic meter." ; obo:SCDO_0000340 obo:NCIT_C64572 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000505" ; oboInOwl:hasDbXref "NCIT:C64572" ; oboInOwl:hasExactSynonym "Gram per Cubic Meter", "Microgram per Milliliter", "Microgram/Milliliter", "Milligram per Cubic Decimeter", "Milligram per Liter", "Nanogram per Microliter", "g/m3", "gram(s)/cubic meter", "gram/cubic meter", "mcg/mL", "mg/L", "mg/dm3", "mg/l", "microgram per milliliter", "microgram per millilitre", "microgram(s)/millilitre", "microgram/millilitre", "milligram per liter", "milligram(s)/litre", "ng/uL", "ug/mL", "ug/ml", "µg/mL" ; a owl:Class ; rdfs:label "microgram per millilitre" ; rdfs:subClassOf obo:UO_0000180 . obo:NCIT_C64625 obo:IAO_0000115 "A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C64625" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008454" ; oboInOwl:hasDbXref "NCIT:C64625" ; oboInOwl:hasExactSynonym "3-(Aminomethyl)-5-methyl-hexanoic Acid", "3-Isobutyl GABA", "CI 1008", "Lyrica", "PD 144723" ; a owl:Class ; rdfs:label "Pregabalin" ; rdfs:subClassOf obo:SCDO_0000809, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000228 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C64783 obo:IAO_0000115 "A unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one deciliter (100 milliliters). The concept also refers to the metric unit of mass density (volumic mass) defined as the density of substance which mass equal to one gram occupies the volume one deciliter." ; obo:SCDO_0000340 obo:NCIT_C64783 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000620" ; oboInOwl:hasDbXref "NCIT:C64783" ; oboInOwl:hasExactSynonym "Gram per Deciliter", "Gram/Deciliter", "g/dl", "gram per deciliter" ; a owl:Class ; rdfs:label "g/dL" ; rdfs:subClassOf obo:UO_0000180 . obo:NCIT_C67015 obo:IAO_0000115 "A unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters." ; obo:SCDO_0000340 obo:NCIT_C67015 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000646" ; oboInOwl:hasDbXref "NCIT:C67015" ; oboInOwl:hasExactSynonym "Milligram per Deciliter", "Milligram/Deciliter", "mg/dl" ; a owl:Class ; rdfs:label "mg/dL" ; rdfs:subClassOf obo:UO_0000180 . obo:NCIT_C67244 obo:IAO_0000115 "A unit of cell concentration expressed as a number of cells in thousands per unit volume equal to one microliter." ; obo:SCDO_0000340 obo:NCIT_C67244 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000511" ; oboInOwl:hasDbXref "NCIT:C67244" ; oboInOwl:hasExactSynonym "1000 cells/µL", "10E3 Cells/uL", "10^3 Cells/uL", "10^3{Cells}/uL", "Thousand Cells per Microliter", "Thousand Cells/cu mm;", "thousand cells per microliter", "thousand cells/µL", "thousands/µL" ; a owl:Class ; rdfs:label "thousand cells per microliter" ; rdfs:subClassOf obo:UO_0000316 . obo:NCIT_C67251 obo:IAO_0000115 "A unit of cell concentration expressed as a number of cells in millions per unit volume equal to one microliter." ; obo:SCDO_0000340 obo:NCIT_C67251 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000504" ; oboInOwl:hasDbXref "NCIT:C67251" ; oboInOwl:hasExactSynonym "10E6 cells/uL", "10^6 Cells/uL", "10^6{Cells}/uL", "Million Cells per Microliter", "Million Cells/cu mm", "million cells per microliter", "million cells per microlitre", "million cells/µL" ; a owl:Class ; rdfs:label "million cells per microliter" ; rdfs:subClassOf obo:UO_0000316 . obo:NCIT_C67376 obo:IAO_0000115 "Unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of one international unit per one liter of the system volume." ; obo:SCDO_0000340 obo:NCIT_C67376 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000658" ; oboInOwl:hasDbXref "NCIT:C67376" ; oboInOwl:hasExactSynonym "IE/L", "International Unit per Liter", "International Unit per Litre", "International Unit/Liter", "International Unit/Litre", "Microinternational Unit per Microliter", "Milliinternational Unit per Milliliter" ; a owl:Class ; rdfs:label "IU/L" ; rdfs:subClassOf obo:UO_0000051 . obo:NCIT_C68615 obo:IAO_0000115 "The calendar date on which a person was born." ; obo:SCDO_0000340 obo:NCIT_C68615 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000544" ; oboInOwl:hasDbXref "NCIT:C68615" ; oboInOwl:hasExactSynonym "BD", "DOB", "Date of Birth" ; a owl:Class ; rdfs:label "Birth Date" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_1000537 . obo:NCIT_C69256 obo:IAO_0000115 "A unique identifier for a subject in a study." ; obo:SCDO_0000340 obo:NCIT_C69256 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000469" ; oboInOwl:hasDbXref "NCIT:C69256" ; oboInOwl:hasExactSynonym "Participant ID", "Participant Identifier", "Participant Number", "Research Subject ID", "Subject ID", "Subject Identification Code", "Subject Identifier", "Subject UID", "Subject Unique Identifier", "Subject's Unique Identifier", "Subject.identifier", "SubjectIdentifier", "USUBJID", "Unique Subject Identifier" ; a owl:Class ; rdfs:comment "The unique identification of a subject in a specified context. NOTE(S): This class is a resolution of the requirement for noting the type of an identifier which is not handled by the purely technical HL7 II data type.; A unique symbol that establishes identity of the subject. EXAMPLE(S): study subject number 7 on a specific study OTHER NAME(S): NOTE(S):; Unique Identifier of patient or fetus who is the subject of observations.; The unique identification of a subject in a specified context." ; rdfs:label "Subject Unique Identifier" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_0300004, obo:SCDO_0300005 . obo:NCIT_C70731 obo:IAO_0000115 "A unique identifier assigned to each clinical trial subject to protect the subject's identity and used in lieu of the subject's name when the investigator reports adverse events and/or other trial-related data." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C70731" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000002" ; oboInOwl:hasDbXref "NCIT:C70731" ; oboInOwl:hasExactSynonym "Clinical Study Subject Unique Identifier", "Clinical Trial Subject Unique Identifier" ; a owl:Class ; rdfs:label "Clinical Trial Subject Unique Identifier" ; rdfs:subClassOf obo:NCIT_C69256 . obo:NCIT_C70817 obo:IAO_0000115 "The formal plan of an experiment or research activity, including the objective, rationale, design, materials and methods for the conduct of the study; intervention description, and method of data analysis." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000096" ; oboInOwl:hasDbXref "NCIT:C70817" ; a owl:Class ; rdfs:label "Study Protocol" ; rdfs:subClassOf obo:SCDO_0300005 . obo:NCIT_C71375 obo:IAO_0000115 "A method of ultrasound imaging in which the ultrasound probe is pressed against the skin of the abdomen in order to create an image of the abdominal organs." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000005" ; oboInOwl:hasDbXref "NCIT:C71375" ; oboInOwl:hasExactSynonym "Abdominal Sonogram", "TUS", "Transabdominal Ultrasound" ; a owl:Class ; rdfs:label "Abdominal Ultrasound" ; rdfs:subClassOf obo:NCIT_C17230 . obo:NCIT_C71746 obo:IAO_0000115 "Difficulties related to an apparatus used to gain access to arteries and veins." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000389" ; oboInOwl:hasDbXref "NCIT:C71746" ; a owl:Class ; rdfs:label "Vascular Access Device Complications" ; rdfs:subClassOf obo:NCIT_C78254 . obo:NCIT_C71754 obo:IAO_0000115 "Having no known name or identity or known source." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007242" ; oboInOwl:hasDbXref "NCIT:C71754" ; a owl:Class ; rdfs:label "Anonymous" ; rdfs:subClassOf obo:SCDO_0002125 . obo:NCIT_C74096 obo:IAO_0000115 "Of your own free will or design; not forced or compelled; controlled by individual volition." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001874" ; oboInOwl:hasDbXref "NCIT:C74096" ; a owl:Class ; rdfs:label "Voluntary" ; rdfs:subClassOf obo:SCDO_0300005 . obo:NCIT_C74954 obo:IAO_0000115 "The quantitative measurement of liver enzymes in the blood, which is useful in assessing the functional state of a patient's liver. Liver function tests include the measurement of albumin, alanine transaminase, aspartate transaminase, alkaline phosphatase, bilirubin, and gamma glutamyl transferase." ; obo:SCDO_0000303 "Other LFTs to be added here? There are more in NCIT" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Liver Function - Assay #190801" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000695" ; oboInOwl:hasDbXref "NCIT:C74954" ; oboInOwl:hasExactSynonym "LFT", "Liver Function Assay", "Liver Function Assays", "Liver Function Tests" ; a owl:Class ; rdfs:label "Liver Function Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:NCIT_C75434 obo:IAO_0000115 "Hemoglobin subunit alpha (142 aa, ~15 kDa) is encoded by both the human HBA1 and human HBA2 genes. This protein plays a role in the distribution of oxygen from the lungs to other organs and tissues." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000365" ; oboInOwl:hasDbXref "NCIT:C75434" ; oboInOwl:hasExactSynonym "Alpha Globin", "Alpha-Globin", "Alpha-Globin Chain", "Haemoglobin Alpha Chain", "Haemoglobin Subunit Alpha", "Hemoglobin Alpha Chain", "Hemoglobin Subunit Alpha" ; a owl:Class ; rdfs:label "Hemoglobin Subunit Alpha" ; rdfs:subClassOf obo:SCDO_1000105 . obo:NCIT_C75583 obo:IAO_0000115 "Examination of the anterior segment of the eye using a medical instrument called a slit lamp." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C75583" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001078" ; oboInOwl:hasDbXref "NCIT:C75583" ; oboInOwl:hasExactSynonym "SLIT LAMP", "Slit-Lamp Biomicroscopy", "Slit-Lamp Eye Exam" ; a owl:Class ; rdfs:label "Slit-Lamp Examination" ; rdfs:subClassOf obo:NCIT_C38060, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0001077 ] . obo:NCIT_C78254 obo:IAO_0000115 "Any problem arising from the use of a medical device." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000385" ; oboInOwl:hasDbXref "NCIT:C78254" ; a owl:Class ; rdfs:label "Device Complication" ; rdfs:subClassOf obo:NCIT_C2959 . obo:NCIT_C78393 obo:IAO_0000115 "Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death." ; obo:SCDO_0000303 """Perhaps suggest that NCIT merges this term with \"Hemochromatosis\", which they have as a separate term. Sub-classes need to be worked on further. Consider sub-classes of \"hemochromatosis\" in the DO. Include Hemosiderosis as a sub-class?""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C78393" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001945" ; oboInOwl:hasDbXref "NCIT:C78393" ; oboInOwl:hasExactSynonym "Diabetes Bronze", "Haemochromatosis", "Hemochromatosis", "Iron Storage Disorder" ; a owl:Class ; rdfs:label "Iron Overload" ; rdfs:subClassOf obo:SCDO_0002674, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C78598 obo:IAO_0000115 "An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C78598" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007836" ; oboInOwl:hasDbXref "NCIT:C78598" ; oboInOwl:hasExactSynonym "Reversible Posterior Leukoencephalopathy Syndrome" ; a owl:Class ; rdfs:label "Posterior Reversible Leukoencephalopathy" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:NCIT_C78638 obo:IAO_0000115 "The development of a blood clot in a catheter." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000388" ; oboInOwl:hasDbXref "NCIT:C78638" ; a owl:Class ; rdfs:label "Thrombus in Catheter" ; rdfs:subClassOf obo:NCIT_C78254 . obo:NCIT_C78652 obo:IAO_0000115 "A parent report or patient self report for measuring health-related quality of life (HRQOL) in healthy children and adolescents and those with acute and chronic health conditions. The PedsQL Measurement Model uses a modular approach that integrates both generic core scales and disease-specific modules into one measurement system. (Copyright 1998-2008 James W. Varni, Ph.D.)" ; obo:SCDO_0000340 ; obo:SCDO_0000481 "Self; Proxy (Parent report)" ; obo:SCDO_0000482 "Clinic patients" ; obo:SCDO_0000484 "Many measures available in Spanish, French and Portuguese" ; obo:SCDO_0001222 "Toddlers; Children; Adolescents" ; obo:SCDO_0001335 "yes" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000875" ; dc:source "Varni, J. W., Seid, M., and Kurtin, P. S. (2001). PedsQL 4.0: Reliability and validity of the 86 pediatric quality of life inventory version 4.0 generic core scales in healthy and patient populations. Medical Care, 39, 800-812." ; oboInOwl:hasDbXref "NCIT:C78652" ; oboInOwl:hasExactSynonym "Pediatric Quality of Life Inventory", "PedsQL" ; a owl:Class ; rdfs:label "Pediatric Quality of Life Inventory (PedsQL)" ; rdfs:subClassOf obo:SCDO_0000952 . obo:NCIT_C79903 obo:IAO_0000115 "A sample of blood applied in a thin film to a microscope slide for study under a microscope." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0008915" ; oboInOwl:hasDbXref "NCIT:C79903" ; a owl:Class ; rdfs:label "Blood Smear" ; rdfs:subClassOf obo:SCDO_0000133 . obo:NCIT_C80411 obo:IAO_0000115 "A diagnostic procedure in which a catheter is guided into the right heart, where pressures may be measured and radiocontrast material may be injected to visualize blood flow in and around the right heart." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C80411" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001012" ; oboInOwl:hasDbXref "NCIT:C80411" ; oboInOwl:hasExactSynonym "Pulmonary Artery Catheterization", "Swan-Ganz Catheterization" ; a owl:Class ; rdfs:label "Right Heart Catheterization" ; rdfs:subClassOf obo:SCDO_0000500, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0000190 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C81229 obo:IAO_0000115 "A description of an individual's current and past experience with alcoholic beverage consumption." ; obo:SCDO_0000303 "Add other terms in the PhenX \"Alcohol Use\" collection?" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C81229" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000040" ; oboInOwl:hasDbXref "NCIT:C81229" ; a owl:Class ; rdfs:label "Alcohol Use History" ; rdfs:subClassOf obo:SCDO_0001120 . obo:NCIT_C81262 obo:IAO_0000115 "An identifying number within an institution that is used to reference a subject's medical information." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000853" ; oboInOwl:hasDbXref "NCIT:C81262" ; a owl:Class ; rdfs:label "Medical Record Number" ; rdfs:subClassOf obo:NCIT_C69256 . obo:NCIT_C82909 obo:IAO_0000115 "Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C82909" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003672" ; oboInOwl:hasDbXref "NCIT:C82909" ; a owl:Class ; rdfs:label "Mild Anemia" ; rdfs:subClassOf obo:HP_0001903 . obo:NCIT_C83031 obo:IAO_0000115 "The date on which a visit occurred." ; obo:SCDO_0000340 obo:NCIT_C83031 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000540" ; oboInOwl:hasDbXref "NCIT:C83031" ; oboInOwl:hasExactSynonym "Clinical Visit Date" ; a owl:Class ; rdfs:label "Visit Date" ; rdfs:subClassOf obo:EUPATH_0000310, obo:SCDO_1000537 . obo:NCIT_C84481 obo:IAO_0000115 "An inherited metabolic disorder characterized by iron accumulation in the tissues." ; obo:SCDO_0000340 obo:NCIT_C84481 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000512" ; oboInOwl:hasDbXref "NCIT:C84481" ; oboInOwl:hasExactSynonym "Congenital Haemochromatosis", "Hereditary Haemochromatosis", "Iron Overload Disease", "Primary Haemochromatosis" ; a owl:Class ; rdfs:label "Hereditary Hemochromatosis" ; rdfs:subClassOf obo:NCIT_C78393 . obo:NCIT_C84979 obo:IAO_0000115 "Hemoglobin subunit epsilon (147 aa, ~16 kDa) is encoded by the human HBE1 gene. This protein plays a role in the transport of oxygen to tissues of the embryo." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C84979" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001381" ; oboInOwl:hasDbXref "NCIT:C84979" ; oboInOwl:hasExactSynonym "Epsilon-Globin", "Haemoglobin Epsilon Chain", "Haemoglobin Subunit Epsilon", "Hemoglobin Epsilon Chain" ; a owl:Class ; rdfs:label "Hemoglobin Subunit Epsilon" ; rdfs:subClassOf obo:SCDO_1000012 . obo:NCIT_C84980 obo:IAO_0000115 "A type of polypeptide chain that when in combination with alpha globin polypeptide chains forms adult hemoglobin 2 (HbA2). HbA2 comprises around 3% of adult hemoglobin. Hemoglobin subunit delta (147 aa, ~16 kDa) is encoded by the human HBD gene. This protein plays a role in the transport of oxygen to tissues of the adult body." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C84980", "https://www.ncbi.nlm.nih.gov/gene/3045" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000011" ; oboInOwl:hasDbXref "NCIT:C84980" ; oboInOwl:hasExactSynonym "Delta Globin", "Delta-Globin", "Haemoglobin Delta Chain", "Haemoglobin Subunit Delta", "Hemoglobin Delta Chain" ; a owl:Class ; rdfs:label "Hemoglobin Subunit Delta" ; rdfs:subClassOf obo:SCDO_1000012 . obo:NCIT_C84981 oboInOwl:hasDbXref "NCIT:C84981" . obo:NCIT_C84982 oboInOwl:hasDbXref "NCIT:C84982" . obo:NCIT_C84983 obo:IAO_0000115 "Hemoglobin subunit beta (147 aa, ~16 kDa) is encoded by the human HBB gene. This protein plays a role in the transport of oxygen to tissues of the adult body." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000358" ; oboInOwl:hasDbXref "NCIT:C84983" ; oboInOwl:hasExactSynonym "Beta Globin", "Beta Globin Chain", "Beta-Globin", "Beta-Globin Chain", "HBB", "Haemoglobin Beta Chain", "Haemoglobin Subunit Beta", "Hemoglobin Beta Chain" ; a owl:Class ; rdfs:label "Hemoglobin Subunit Beta" ; rdfs:subClassOf obo:SCDO_1000012 . obo:NCIT_C85397 obo:IAO_0000115 "Measurement of the breathing capacity of the lung by means of a spirometer." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001100" ; oboInOwl:hasDbXref "NCIT:C85397" ; a owl:Class ; rdfs:label "Spirometry" ; rdfs:subClassOf obo:SCDO_0000942, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0001099 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C86008 obo:IAO_0000115 "A product of hemoglobin produced by oxidation of the iron atom from the ferrous to the ferric state." ; obo:SCDO_0000340 obo:NCIT_C86008 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000167" ; oboInOwl:hasDbXref "NCIT:C86008" ; oboInOwl:hasExactSynonym "MetHb" ; a owl:Class ; rdfs:label "Methemoglobin" ; rdfs:subClassOf obo:NCIT_C16676 . obo:NCIT_C91105 obo:IAO_0000115 "An instrument consisting of a predetermined set of questions for a clinical or research assessment." ; obo:SCDO_0000340 obo:NCIT_C91105 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000476" ; oboInOwl:hasDbXref "NCIT:C91105" ; a owl:Class ; rdfs:label "Clinical or Research Assessment Questionnaire" ; rdfs:subClassOf obo:SCDO_1000472 . obo:NCIT_C91106 obo:IAO_0000115 "A statement (either spoken or written) that is made in reply to a clinical research assessment question." ; obo:SCDO_0000340 obo:NCIT_C91106 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000473" ; oboInOwl:hasDbXref "NCIT:C91106" ; oboInOwl:hasExactSynonym "Clinical or Research Assessment Response" ; a owl:Class ; rdfs:label "Clinical or Research Assessment Answer" ; rdfs:subClassOf obo:SCDO_1000472 . obo:NCIT_C92755 obo:IAO_0000115 "The biopsy of placental tissue containing the chorionic villi from the maternal uterus in early pregnancy to diagnose fetal genetic defects." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C92755" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000223" ; oboInOwl:hasDbXref "NCIT:C92755" ; oboInOwl:hasExactSynonym "CVS" ; a owl:Class ; rdfs:label "Chorionic Villus Sampling" ; rdfs:subClassOf obo:SCDO_0000919 . obo:NCIT_C92803 obo:IAO_0000115 "Testing to determine if there is a predisposition or indication of a possible genetic or a chromosomal abnormality." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C92803" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000446" ; oboInOwl:hasDbXref "NCIT:C92803" ; a owl:Class ; rdfs:label "Genetic Screening" ; rdfs:subClassOf obo:NCIT_C15709 . obo:NCIT_C92853 obo:IAO_0000115 "Hemorrhage defined as a blood loss in excess of 500 mL after vaginal delivery or more than 1000 mL after a cesarean delivery." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000916" ; oboInOwl:hasDbXref "NCIT:C92853" ; a owl:Class ; rdfs:label "Postpartum Hemorrhage" ; rdfs:subClassOf obo:HP_0001197, obo:HP_0001871, obo:NCIT_C34941, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ] . obo:NCIT_C93407 obo:IAO_0000115 "Specific key measurement(s) or observation(s) used to measure the effect of experimental variables on the subjects in a study, or for observational studies, to describe patterns of diseases or traits or associations with exposures, risk factors or treatment. The specific measure that receives the most emphasis in assessment." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C93407" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001116" ; oboInOwl:hasDbXref "NCIT:C93407" ; oboInOwl:hasExactSynonym "Study Outcome Measure" ; a owl:Class ; rdfs:label "Study Outcome Measurement" ; rdfs:subClassOf obo:SCDO_0300005 . obo:NCIT_C95437 obo:IAO_0000115 "An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C95437" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005115" ; oboInOwl:hasDbXref "NCIT:C95437" ; a owl:Class ; rdfs:label "Acute Pancreatitis" ; rdfs:subClassOf obo:HP_0025031, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C95504 obo:IAO_0000115 "A form of alpha thalassemia that results from reduced protein production from three of the four alpha-globin genes. Clinically it is characterized by chronic hemolytic anemia." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95504" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000534" ; oboInOwl:hasDbXref "NCIT:C95504" ; oboInOwl:hasExactSynonym "Alpha-Thalassemia Intermedia", "Haemoglobin H Disease", "Hb H-Disease" ; a owl:Class ; rdfs:label "Hemoglobin H Disease" ; rdfs:subClassOf obo:SCDO_0000042, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0003894 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0008888 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:EUPATH_0000034 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0004870 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0001384 ] . obo:NCIT_C95534 obo:IAO_0000115 "A condition in which a person is heterozygous for a globin gene, with one normal allele and one defective allele." ; obo:SCDO_0000303 "NCIT includes this class below \"Hemoglobinopathy\", hence its inclusion here." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95534" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000550" ; oboInOwl:hasDbXref "NCIT:C95534" ; oboInOwl:hasExactSynonym "Heterozygous Hemoglobinopathy" ; a owl:Class ; rdfs:label "Hemoglobin Trait" ; rdfs:subClassOf obo:SCDO_0000552 . obo:NCIT_C95535 obo:IAO_0000115 "A condition in which a person has reduced protein production from two of the four alpha-globin alleles." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95535" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000044" ; dc:source ; oboInOwl:hasDbXref "NCIT:C95535" ; oboInOwl:hasExactSynonym "Alpha-Thalassemia Trait" ; a owl:Class ; rdfs:comment "-/- alpha/alpha or -/alpha -/alpha. It can exist in two forms: (1) alpha-thal-1 (alpha alpha/--), involves cis deletion of both alpha genes on the same chromosome; (2) alpha-thal-2 (alpha-/alpha-), involves trans deletion of alpha genes this occurs on different (homologous) chromosomes." ; rdfs:label "Alpha Thalassemia Trait" ; rdfs:subClassOf obo:SCDO_0000551, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000251 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:EUPATH_0000034 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001386 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C3833 ] . obo:NCIT_C95536 obo:IAO_0000115 "A condition in which a person has reduced protein production from one of the four alpha-globin alleles." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95536" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000043" ; dc:source ; oboInOwl:hasDbXref "NCIT:C95536" ; oboInOwl:hasExactSynonym "Alpha Thalassemia Silent", "Alpha-Thalassemia Silent Carrier" ; a owl:Class ; rdfs:label "Alpha Thalassemia Silent Carrier" ; rdfs:subClassOf obo:SCDO_0000551, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:EUPATH_0000034 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001386 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C3833 ] . obo:NCIT_C95539 obo:IAO_0000115 "A compound heterozygous state in which a person has a hemoglobin S allele along with a beta-thalassemia allele. The severity of the condition is determined to a large extent by the quantity of normal hemoglobin produced by the beta-thalassemia gene." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001057" ; oboInOwl:hasDbXref "NCIT:C95539" ; oboInOwl:hasExactSynonym "Hb S-Beta Thalassemia", "HbS-Beta-Thalassemia Syndrome", "HbSBetaThal", "S Beta-Thalassemia", "S-Beta Thalassemia", "Sickle Beta Thalassaemia", "Sickle Beta-Thalassaemia", "Sickle Cell Beta Thalassemia Disease", "Sickle Cell Disease-S Beta Thalassaemia", "Sickle Cell-Beta Thalassaemia", "Sickle Cell-Beta-Thalassemia", "Sickle Cell-Beta-Thalassemia Disease Syndrome" ; a owl:Class ; rdfs:label "Sickle Beta Thalassemia" ; rdfs:subClassOf obo:SCDO_0007656, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000107 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0009731 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:HP_0011906 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000240 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:NCIT_C96239 obo:IAO_0000115 "A morphologic finding indicating enlargement of the glomeruli in a kidney specimen." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002784" ; oboInOwl:hasDbXref "NCIT:C96239" ; a owl:Class ; rdfs:label "Glomerular Hypertrophy" ; rdfs:subClassOf obo:HP_0000077 . obo:NCIT_C96391 obo:IAO_0000115 "A conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C96391" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006120" ; oboInOwl:hasDbXref "NCIT:C96391" ; oboInOwl:hasExactSynonym "MCV4", "Menactra", "Meningococcal Conjugate Vaccine MCV-4", "Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugated Vaccine", "Menveo" ; a owl:Class ; rdfs:label "Meningococcal Conjugate Vaccine MCV4" ; rdfs:subClassOf obo:VO_0000001, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C97120 obo:IAO_0000115 "An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It is indicated for disease caused by serotypes 1, 5, 4, 6B, 7, 9V, 14, 18C, 19F, and 23F." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C97120" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000909" ; oboInOwl:hasDbXref "NCIT:C97120" ; oboInOwl:hasExactSynonym "PCV 10" ; a owl:Class ; rdfs:label "Pneumococcal 10-Valent Conjugate Vaccine" ; rdfs:subClassOf obo:NCIT_C97123 . obo:NCIT_C97121 obo:IAO_0000115 "A pneumococcal conjugate vaccine containing 13 different strains of the bacterium Streptococcus pneumoniae, used in children and studied in immunocompromised patients for the prevention of pneumococcal disease. The pneumococcal 13-valent conjugate vaccine contains capsular antigen polysaccharides derived from the S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F that are individually conjugated to a nontoxic diphtheria cross-reactive material (CRM) carrier protein (CRM197). Upon vaccination, pneumococcal 13-valent conjugate vaccine induces active immunization against 13 different serotypes of S. pneumoniae and protects against pneumococcal disease." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C97121" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000910" ; oboInOwl:hasDbXref "NCIT:C97121" ; oboInOwl:hasExactSynonym "PCV 13", "PCV13 Vaccine", "Prevnar 13" ; a owl:Class ; rdfs:label "Pneumococcal 13-Valent Conjugate Vaccine" ; rdfs:subClassOf obo:NCIT_C97123, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:NCIT_C97123 obo:IAO_0000115 "An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes individually conjugated to proteins." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C97123" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000275" ; oboInOwl:hasDbXref "NCIT:C97123" ; oboInOwl:hasExactSynonym "Pneumococcal Conjugate Vaccine" ; a owl:Class ; rdfs:label "Conjugate Pneumococcal Vaccine" ; rdfs:subClassOf obo:VO_0000675, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:NCIT_C98805 obo:IAO_0000115 "Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000013" ; oboInOwl:hasDbXref "NCIT:C98805" ; a owl:Class ; rdfs:label "Acquired Methemoglobinemia" ; rdfs:subClassOf obo:SCDO_0000753 . obo:NCIT_C98835 obo:IAO_0000115 "A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease." ; obo:SCDO_0000303 "Requires further refinement." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98835" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001058" ; oboInOwl:hasDbXref "NCIT:C98835" ; oboInOwl:hasExactSynonym "Hb S Beta 0 Thalassemia", "Hemoglobin S Beta 0 Thalassemia", "S Beta 0 Thalassemia", "S beta-zero", "Sickle Beta 0 Thalassemia", "Sickle Beta Zero Thalassemia", "Sickle Cell-Beta 0 Thalassemia", "Sickle Cell-Beta Zero Thalassemia" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S Beta Zero Thalassemia" ; rdfs:subClassOf obo:NCIT_C95539, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000241 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:NCIT_C99042 obo:IAO_0000115 "The formation of a thrombus in the renal vein." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C99042" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005061" ; oboInOwl:hasDbXref "NCIT:C99042" ; a owl:Class ; rdfs:label "Renal Vein Thrombosis" ; rdfs:subClassOf obo:HP_0000077, obo:HP_0001977, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:NCIT_C99063 obo:IAO_0000115 "Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence." ; obo:SCDO_0000303 "Can be treated with exchange transfusion (SCDO:0001303)" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C99063" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005226" ; oboInOwl:hasDbXref "NCIT:C99063" ; a owl:Class ; rdfs:label "Spinal Cord Infarction" ; rdfs:subClassOf obo:HP_0012639, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:OBI_0000185 obo:IAO_0000115 "An assay that produces a picture of an entity." ; obo:SCDO_0000303 "Perhaps replace this term with \"Diagnostic Imaging\" from NCIT?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OBI_0000185" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000612" ; oboInOwl:hasDbXref "OBI:0000185" ; a owl:Class ; rdfs:label "Imaging Assay" ; rdfs:subClassOf obo:SCDO_0000082 . obo:OBI_0000626 obo:IAO_0000115 "A sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument." ; obo:SCDO_0000303 "Add sub-class \"beta-globin gene sequencing\" as per the \"Diagnostic Methods\" section of the term \"Dominant beta-thalassemia\" in Orphanet." ; obo:SCDO_0000340 obo:OBI_0000626 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004249" ; oboInOwl:hasDbXref "OBI:0000626" ; a owl:Class ; rdfs:label "DNA Sequencing" ; rdfs:subClassOf obo:SCDO_0000448 . obo:OBI_0000925 obo:IAO_0000115 "A material entity bearing the disposition to infect an organism" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000638" ; oboInOwl:hasDbXref "OBI:0000925" ; a owl:Class ; rdfs:label "Infectious Agent" ; rdfs:subClassOf obo:SCDO_0000435 . obo:OBI_0000990 obo:IAO_0000115 "A microscope that produces an image of an object by targeting it with an electron beam." ; obo:SCDO_0000340 obo:OBI_0000990 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000422" ; oboInOwl:hasDbXref "OBI:0000990" ; a owl:Class ; rdfs:comment "It is capable of much higher magnifications and has a greater resolving power than a light microscope, allowing it to see much smaller objects in finer detail." ; rdfs:label "Electron Microscope" ; rdfs:subClassOf obo:OBI_0400169 . obo:OBI_0001098 obo:IAO_0000115 "A device that is used to visualize subcutaneous body structures including tendons, muscles, joints, vessels and internal organs." ; obo:SCDO_0000340 obo:OBI_0001098 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001202" ; oboInOwl:hasDbXref "OBI:0001098" ; a owl:Class ; rdfs:label "Ultrasound Machine" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:NCIT_C17230 ] . obo:OBI_0001138 obo:IAO_0000115 "A device that is used to generate X-rays." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OBI_0001138" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001251" ; oboInOwl:hasDbXref "OBI:0001138" ; oboInOwl:hasExactSynonym "Radiographic Unit" ; a owl:Class ; rdfs:label "X-Ray Machine" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000963 ] . obo:OBI_0002140 obo:IAO_0000115 "An assay to determine the temperature of an evaluant." ; obo:SCDO_0000340 obo:OBI_0002140 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000752" ; oboInOwl:hasDbXref "OBI:0002140" ; a owl:Class ; rdfs:label "Temperature Measurement Assay" ; rdfs:subClassOf obo:SCDO_0000902 . obo:OBI_0002146 obo:IAO_0000115 "An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) antigens." ; obo:SCDO_0000340 obo:OBI_0002146 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000195" ; dc:source ; oboInOwl:hasDbXref "OBI:0002146" ; oboInOwl:hasExactSynonym "HIV Antibody Assay" ; a owl:Class ; rdfs:comment "The window period for antibody tests in most people is somewhere between 3 to 12 weeks from the time of infection." ; rdfs:label "HIV Antibody Test" ; rdfs:subClassOf obo:SCDO_0000571 . obo:OBI_0002556 obo:IAO_0000115 "A value specifcation that specifies the youngest age when specifying an age range." ; obo:SCDO_0000340 obo:OBI_0002556 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000405" ; oboInOwl:hasDbXref "OBI:0002556" ; a owl:Class ; rdfs:label "Minimum Age Value Specification" ; rdfs:subClassOf obo:SCDO_1000401 . obo:OBI_0002557 obo:IAO_0000115 "A value specifcation that specifies the oldest age when specifying an age range." ; obo:SCDO_0000340 obo:OBI_0002557 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000404" ; oboInOwl:hasDbXref "OBI:0002557" ; a owl:Class ; rdfs:label "Maximum Age Value Specification" ; rdfs:subClassOf obo:SCDO_1000401 . obo:OBI_0200198 obo:IAO_0000115 "A data transformation that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules)." ; obo:SCDO_0000340 obo:OBI_0200198 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001138" ; dc:source obo:OBI_0200198 ; oboInOwl:hasDbXref "OBI:0200198" ; oboInOwl:hasExactSynonym "MS/MS", "Tandem MS" ; a owl:Class ; rdfs:comment "Example of usage: A precursor ion is selected in the first stage, allowed to fragment and then all resultant masses are scanned in the second mass analyzer and detected in the detector that is positioned after the second mass analyzer. This experiment is commonly performed to identify transitions used for quantification by tandem MS." ; rdfs:label "Tandem Mass Spectrometry" ; rdfs:subClassOf obo:SCDO_0000216 . obo:OBI_0400115 obo:IAO_0000115 "A spectrophotometer is an instrument that measures the intensity of light as a function of the color, or more specifically, the wavelength of light, transmitted by a substance." ; obo:SCDO_0000340 obo:OBI_0400115 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001096" ; oboInOwl:hasDbXref "OBI:0400115" ; a owl:Class ; rdfs:label "Spectrophotometer" ; rdfs:subClassOf obo:SCDO_0000376 . obo:OBI_0400169 obo:IAO_0000115 "A microscope is an instrument which magnifies the view on objects (too small to be viewed by the naked eye) under increased resolution. A microscope can be an optical instrument but also and electronic instrument. There are various kind of optical microscopes, e.g confocal microscope, epifluoresence microscope)." ; obo:SCDO_0000340 obo:OBI_0400169 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000757" ; oboInOwl:hasDbXref "OBI:0400169" ; a owl:Class ; rdfs:label "Microscope" ; rdfs:subClassOf obo:SCDO_0000376 . obo:OBI_1110053 obo:IAO_0000115 "A disease characterized by abnormal and uncontrolled cell division." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OBI_1110053" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000180" ; oboInOwl:hasDbXref "OBI:1110053" ; oboInOwl:hasExactSynonym "Malignancy", "Malignant Neoplasia", "Malignant Neoplasm", "Malignant Tumor", "Malignant Tumour" ; a owl:Class ; rdfs:label "Cancer" ; rdfs:subClassOf obo:SCDO_0000267, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001252 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:OGMS_0000023 obo:IAO_0000115 "A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species." ; obo:SCDO_0000303 """Sub-classes to be added?: -- increased lactate dehydrogenase level (in Ontology of Adverse Events AOE) -- decreased lactate dehydrogenase level (Mammalian Phenotype Ontology) -- Splenomegaly (link this to Spleen Examination) -- Obstructive Hydrocephalus (see \"Cerebellar Hemorrhage\") -- Failure to Thrive (MeSH) -- Cardiac Output, Low (MeSH) -- Cardiac Output, High (MeSH) -- Add the sub-class \"Clinical Phenotype\" from Ontology for General Medical Science""" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/OGMS?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FOGMS_0000023" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000893" ; oboInOwl:hasDbXref "OGMS:0000023" ; a owl:Class ; rdfs:label "Phenotype" ; rdfs:subClassOf obo:SCDO_0001000 . obo:OGMS_0000028 obo:IAO_0000115 "A clinically abnormal phenotype that is characteristic of a single disease." ; obo:SCDO_0000340 obo:OGMS_0000028 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000185" ; oboInOwl:hasDbXref "OGMS:0000028" ; a owl:Class ; rdfs:label "Disease Phenotype" ; rdfs:subClassOf obo:OGMS_0000023 . obo:OGMS_0000046 obo:IAO_0000115 "A disorder whose etiology involves (1) a modification to the patient's genomic DNA which leads to alterations in the normal expression pattern of the genome, but is (2) not a change in the nucleotide sequence." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OGMS_0000046" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000439" ; oboInOwl:hasDbXref "OGMS:0000046" ; oboInOwl:hasExactSynonym "Epigenomic Disorder" ; a owl:Class ; rdfs:label "Epigenetic Disorder" ; rdfs:subClassOf obo:SCDO_0000444 . obo:OGMS_0000047 obo:IAO_0000115 "A disorder whose etiology involves an abnormality in the nucleotide sequence of an organism's genome." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OGMS_0000047" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000445" ; oboInOwl:hasDbXref "OGMS:0000047" ; a owl:Class ; rdfs:label "Genetic Disorder" ; rdfs:subClassOf obo:DOID_4, obo:SCDO_0000444 . obo:OGMS_0000051 obo:IAO_0000115 "A genetic disorder inherited during conception that is part of all cells in the organism." ; obo:SCDO_0000303 "Perhaps remove this class but keep sub-classes? Or include the class \"Acquired Genetic Disorder\" as a sibling of this class if terms are included that can be sub-classes of it?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OGMS_0000051" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000279" ; oboInOwl:hasDbXref "OGMS:0000051" ; a owl:Class ; rdfs:label "Constitutional Genetic Disorder" ; rdfs:subClassOf obo:OGMS_0000047 . obo:OGMS_0000088 obo:IAO_0000115 "A communication from a patient about something they perceive as being abnormal about their body or life." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OGMS_0000088" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000872" ; oboInOwl:hasDbXref "OGMS:0000088" ; a owl:Class ; rdfs:label "Patient Symptom Report" ; rdfs:subClassOf obo:SCDO_0000738 . obo:OPMI_0000023 obo:IAO_0000115 "An answer to question where the answer is Yes." ; obo:SCDO_0000340 obo:OPMI_0000023 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000563" ; oboInOwl:hasDbXref "OPMI:0000023" ; oboInOwl:hasExactSynonym "yes answer to question" ; a owl:Class ; rdfs:label "Yes" ; rdfs:subClassOf obo:NCIT_C91106 . obo:OPMI_0000024 obo:IAO_0000115 "An answer to question where the answer is No." ; obo:SCDO_0000340 obo:OPMI_0000024 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000564" ; oboInOwl:hasDbXref "OPMI:0000024" ; oboInOwl:hasExactSynonym "no answer to question" ; a owl:Class ; rdfs:label "No" ; rdfs:subClassOf obo:NCIT_C91106 . obo:OPMI_0000025 obo:IAO_0000115 "An answer to question that indicates the response to the specified question is unknown." ; obo:SCDO_0000340 obo:OPMI_0000025 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000562" ; oboInOwl:hasDbXref "OPMI:0000025" ; oboInOwl:hasExactSynonym "Don't know", "unknown answer to question" ; a owl:Class ; rdfs:label "Do Not Know" ; rdfs:subClassOf obo:NCIT_C91106 . obo:OPMI_0000027 obo:IAO_0000115 "An answer to question where one declines to answer the specified question." ; obo:SCDO_0000340 obo:OPMI_0000027 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000561" ; oboInOwl:hasDbXref "OPMI:0000027" ; oboInOwl:hasExactSynonym "Refuse to answer", "Refused to answer", "declined to answer question", "declined to answer to question" ; a owl:Class ; rdfs:label "Refused" ; rdfs:subClassOf obo:NCIT_C91106 . obo:OPMI_0000028 obo:IAO_0000115 "An answer to question that is not enumerated in the list and then may be entered with free text in a separate text box" ; obo:SCDO_0000340 obo:OPMI_0000028 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000565" ; oboInOwl:hasDbXref "OPMI:0000028" ; oboInOwl:hasExactSynonym "other answer to question" ; a owl:Class ; rdfs:label "Other" ; rdfs:subClassOf obo:NCIT_C91106 . obo:PR_000001318 obo:IAO_0000115 "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." ; obo:SCDO_0000340 obo:PR_000001318 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000443" ; dc:source ; oboInOwl:hasDbXref "PR:000001318" ; oboInOwl:hasExactSynonym "CD62 Antigen-Like Family Member L", "CD62L", "Lymph Node Homing Receptor" ; a owl:Class ; rdfs:comment "L-selection is a serum marker for neutrophil activation." ; rdfs:label "L-Selectin" ; rdfs:subClassOf obo:NCIT_C26548 . obo:RO_0002200 obo:IAO_0000115 "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." ; obo:SCDO_0000340 obo:RO_0002200 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; oboInOwl:hasDbXref "RO:0002200" ; a owl:ObjectProperty ; rdfs:label "has phenotype" . obo:RO_0002201 obo:IAO_0000115 "Inverse of \"has phenotype\" object property." ; obo:SCDO_0000303 "If required later, specify as inverse of \"has phenotype\" in Protege." ; obo:SCDO_0000340 obo:RO_0002201 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; a owl:ObjectProperty ; rdfs:label "phenotype of" . obo:RO_0002452 obo:IAO_0000115 "A relation that holds between a disease or an organism and a phenotype that is a symptom (subjective evidence of disease perceived by the patient)." ; obo:SCDO_0000303 "Description adapted from RO. Suggest this description be updated in RO." ; obo:SCDO_0000340 obo:RO_0002452 ; oboInOwl:hasDbXref "RO:0002452" ; a owl:ObjectProperty ; rdfs:label "has symptom" ; rdfs:subPropertyOf obo:RO_0002200 . obo:RO_0003302 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." ; obo:SCDO_0000340 obo:RO_0003302 ; oboInOwl:hasDbXref "RO:0003302" ; a owl:ObjectProperty ; rdfs:label "causes or contributes to condition" ; rdfs:subPropertyOf obo:SCDO_1000183 . obo:RO_0003303 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." ; obo:SCDO_0000340 obo:RO_0003303 ; oboInOwl:hasDbXref "RO:0003303" ; oboInOwl:hasExactSynonym "results_in" ; a owl:ObjectProperty ; rdfs:label "causes condition" ; rdfs:subPropertyOf obo:SCDO_1000183 . obo:RO_0003306 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." ; obo:SCDO_0000340 obo:RO_0003306 ; oboInOwl:hasDbXref "RO:0003306" ; a owl:ObjectProperty ; rdfs:label "contributes to frequency of condition" ; rdfs:subPropertyOf obo:SCDO_1000015 . obo:RO_0003307 obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ; obo:SCDO_0000340 obo:RO_0003307 ; oboInOwl:hasDbXref "RO:0003307" ; a owl:ObjectProperty ; rdfs:label "ameliorates condition" ; rdfs:subPropertyOf obo:SCDO_1000015 . obo:RO_0003309 obo:IAO_0000115 "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ; obo:SCDO_0000340 obo:RO_0003309 ; oboInOwl:hasDbXref "RO:0003309" ; a owl:ObjectProperty ; rdfs:label "exacerbates condition" ; rdfs:subPropertyOf obo:SCDO_1000015 . obo:RO_0003310 obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." ; obo:SCDO_0000340 obo:RO_0003310 ; oboInOwl:hasDbXref "RO:0003310" ; a owl:ObjectProperty ; rdfs:label "condition ameliorated by" ; rdfs:subPropertyOf obo:SCDO_1000005 . obo:RO_0003311 obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." ; obo:SCDO_0000340 obo:RO_0003311 ; oboInOwl:hasDbXref "RO:0003311" ; a owl:ObjectProperty ; rdfs:label "condition exacerbated by" ; rdfs:subPropertyOf obo:SCDO_1000005 . obo:SBO_0000316 obo:IAO_0000115 "Single-stranded RNA molecules thought to regulate the expression of other genes. miRNAs are encoded by genes that are transcribed from DNA but not translated into protein (non-coding RNA)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000756" ; oboInOwl:hasDbXref "SBO:0000316" ; oboInOwl:hasExactSynonym "miRNA" ; a owl:Class ; rdfs:label "MicroRNA" ; rdfs:subClassOf obo:NCIT_C26548 . obo:SCDO_0000006 obo:IAO_0000115 "The performance of the basic activities of self care, such as dressing, ambulation, or eating." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000203" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000006" ; oboInOwl:hasDbXref "MESH:D000203" ; oboInOwl:hasExactSynonym "ADL", "Daily Living Activities", "Daily Living Activity", "Self Care (Rehabilitation)", "Self-Care" ; a owl:Class ; rdfs:label "Ability to Carry Out Activities of Daily Living" ; rdfs:subClassOf obo:SCDO_0000900 . obo:SCDO_0000007 obo:IAO_0000115 "A structurally abnormal hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD)." ; obo:SCDO_0000303 "Probably too specific to SCD be included in other ontologies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Structurally Abnormal Hemoglobin Present in SCD" ; a owl:Class ; rdfs:label "Abnormal Hemoglobin in SCD" ; rdfs:subClassOf obo:HP_0001877, obo:SCDO_1000060 . obo:SCDO_0000008 obo:IAO_0000115 "Abnormality in structure and function of the Red Blood Cell." ; obo:SCDO_0000303 "Are there other relevant erythrocyte abnormalities that can be included as children here? If not, this class can be removed and just keep \"Abnormal Hemoglobin\"." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001877" ; obo:SCDO_1000288 "Sufficient" ; oboInOwl:hasExactSynonym "Abnormality of Red Blood Cell", "Abnormality of Red Blood Cells" ; a owl:Class ; rdfs:label "deprecated Abnormality of Erythrocytes" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000010 obo:IAO_0000115 "Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000010" ; oboInOwl:hasDbXref "MESH:D000082" ; oboInOwl:hasExactSynonym "Paracetamol", "Tylenol" ; a owl:Class ; rdfs:label "Acetaminophen" ; rdfs:subClassOf obo:CHEBI_35493, obo:SCDO_0000809, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000016 obo:IAO_0000115 "A condition that co-exists or follows from sickle cell disease and that has a severe and rapid onset of symptoms with short duration." ; obo:SCDO_0000303 "Probably too specific to warrant inclusion into anther ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C14140", "http://purl.bioontology.org/ontology/MESH/Q000150" ; oboInOwl:hasExactSynonym "Acute Complications of SCD" ; a owl:Class ; rdfs:label "Acute Complications of Sickle Cell Disease" ; rdfs:subClassOf obo:NCIT_C2959, obo:SCDO_0000895 . obo:SCDO_0000018 obo:IAO_0000115 "An acute onset of wheezing in a person with SCD who has no co-morbid asthma." ; obo:SCDO_0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." ; obo:SCDO_0000340 "Cohen et al 2011 Am J Hematol., Glassberg et al 2014 Curr Opin Pediatr., Knight-Madden et al 2014 Ped Resp Rev" ; obo:SCDO_0000661 "Etiology may be unclear. May be related to inflammation of SCD and/or viral lower respiratory tract infection." ; obo:SCDO_0000662 "Normal Chest X-ray" ; obo:SCDO_1000288 "None" ; dc:source "Cohen et al 2011 Am J Hematol., Glassberg et al 2014 Curr Opin Pediatr., Knight-Madden et al 2014 Ped Resp Rev" ; a owl:Class ; rdfs:comment """Too specific to SCD to be included in other ontologies? PFTs may be done to asses for airway hyper-responsiveness.""" ; rdfs:label "Acute Non-Specific Wheezing Episode" ; rdfs:subClassOf obo:HP_0002086, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000942 ] . obo:SCDO_0000019 obo:IAO_0000115 "Sickle cell pain management that aims to heal the acute process." ; obo:SCDO_0000303 "Request inclusion into MESH below \"Pain Management\" / \"Sickle Cell Pain Management\" (also to be suggested for inclusion)" ; obo:SCDO_0000340 obo:SCDO_1000152 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Acute Sickle Cell Pain Treatment" ; a owl:Class ; rdfs:label "Acute Sickle Cell Pain Management" ; rdfs:subClassOf obo:SCDO_0001052, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000021 obo:IAO_0000115 "An acute respiratory illness with no lower respiratory tract signs or infiiltrate on chest radiograph." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Acute Upper Respiratory Infection", "URI", "URTI" ; a owl:Class ; rdfs:label "Acute Upper Respiratory Tract Infection" ; rdfs:subClassOf obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000024 obo:IAO_0000115 "The extent to which a person's behaviour - taking medications, following a diet and/or executing life style changes, corresponds to agreed recommendations by a health care provider." ; obo:IAO_0100001 obo:SCDO_0000869 ; obo:SCDO_0000303 "Suggest update to description for \"Patient Compliance\" in MESH." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; dc:source ; oboInOwl:hasDbXref "MESH:D010349" ; oboInOwl:hasExactSynonym "Adherence to Long Term Therapy", "Patient Adherence", "Patient Compliance", "Patient Cooperation" ; a owl:Class ; rdfs:label "deprecated-Adherence" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000026 obo:IAO_0000115 "A 20-item questionnaire that assesses the frequency of severe headaches, the level of pain, whether the person is taking medications, and associated complications such as nausea." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Migraine - Adult\") as we have done." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Migraine - Adult #130501" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:130501" ; a owl:Class ; rdfs:label "Adult Migraine Questionnaire" ; rdfs:subClassOf obo:SCDO_0000760 . obo:SCDO_0000028 obo:IAO_0000115 "An adverse event that occurs after a drug administration." ; obo:SCDO_0000303 "Should this be a sub-class of \"Environmental Disease Modifier\"?" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000005" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000028" ; oboInOwl:hasDbXref "OAE:0000005" ; oboInOwl:hasExactSynonym "ADE", "ADR", "Adverse Drug Reaction", "Drug Adverse Event" ; a owl:Class ; rdfs:label "Adverse Drug Event" ; rdfs:subClassOf obo:SCDO_1000093 . obo:SCDO_0000029 obo:IAO_0000115 "Electrophoresis in which agar or agarose gel is used as the diffusion medium." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D004587" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000029" ; oboInOwl:hasDbXref "MESH:D004587" ; oboInOwl:hasExactSynonym "Agar Gel Electrophoresis" ; a owl:Class ; rdfs:label "Agarose Gel Electrophoresis" ; rdfs:subClassOf obo:SCDO_0000424 . obo:SCDO_0000031 obo:IAO_0000115 "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the age of onset of the phenotype. Age of onset is defined as \"The age group in which disease manifestations appear.\" (HPO)" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "age of onset modified by" ; rdfs:subPropertyOf obo:SCDO_1000005 . obo:SCDO_0000032 obo:IAO_0000115 "A rare congenital disorder characterized by a partial or complete absence (agenesis) of an area of the brain that connects the two cerebral hemispheres. It can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline." ; obo:SCDO_0000303 """Suggest update to description in HPO. Include links to relevant Therapeutics.""" ; obo:SCDO_0000340 obo:HP_0001274, "http://rarediseases.org/rare-diseases/agenesis-of-corpus-callosum/" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasExactSynonym "ACC", "Absence of Corpus Callosum", "Absent Corpus Callosum", "Agenesis of the Corpus Callosum", "Callosal Agenesis", "Corpus Callosum Agenesis", "Dysplastic or Absent Corpus Callosum" ; a owl:Class ; rdfs:label "Agenesis of Corpus Callosum" ; rdfs:subClassOf obo:HP_0002060, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C17230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000443 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001133 ] . obo:SCDO_0000034 obo:IAO_0000115 "A quantitative measurement of alanine aminotransferase present in a blood sample." ; obo:SCDO_0000303 "Suggest update to description in NCIT (from \"Alanine Aminotransferase Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; dc:source ; oboInOwl:hasDbXref "NCIT:C64433" ; oboInOwl:hasExactSynonym "ALT Blood Test", "Alanine Transaminase Blood Test", "Circulating Alanine Transaminase Test", "SGPT Test", "Serum Glutamic-Pyruvic Transaminase Test" ; a owl:Class ; rdfs:label "Alanine Aminotransferase Blood Test" ; rdfs:subClassOf obo:NCIT_C74954, obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000035 ] . obo:SCDO_0000035 obo:IAO_0000115 "The amount of alanine aminotransferase present in a specified volume of blood." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "ALT Level", "Alanine Aminotransferase Level", "Alanine Transaminase Level", "Blood Alanine Transaminase Level", "Circulating Alanine Transaminase Level", "SGPT Level", "Serum Glutamic-Pyruvic Transaminase Level" ; a owl:Class ; rdfs:label "Alanine Aminotransferase Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000034 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0031964 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000830 ] . obo:SCDO_0000037 obo:IAO_0000115 "Increased concentration of albumin in the urine; more than 30mg in 24hours or urine albumin creatinine ratio (ACR) >3 mg/mmol." ; obo:SCDO_0000303 "Suggest update to description in HPO." ; obo:SCDO_0000340 obo:HP_0012592, "http://www.nice.org.uk/guidance/CG182/chapter/introduction" ; obo:SCDO_1000288 "Suggest update to description in HPO." ; dc:source ; oboInOwl:hasDbXref "HP:0012592" ; a owl:Class ; rdfs:comment "Because albuminuria may be affected by non-pathological factors (exercise, menstruation contamination, biological variability, etc.), abnormal values should be confirmed within 1-2 months." ; rdfs:label "Albuminuria" ; rdfs:subClassOf obo:SCDO_0000932, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000055 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001210 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001212 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000038 obo:IAO_0000115 "An indication of whether the respondent has ever consumed any alcoholic beverage during his or her entire life." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Alcohol - Lifetime Use" ; rdfs:subClassOf obo:NCIT_C81229, obo:SCDO_1000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000329 ] . obo:SCDO_0000042 obo:IAO_0000115 "A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted. A hemoglobinopathy with two clinically significant forms: hemoglobin Bart hydrops fetalis (deletion of all 4 alpha-globin genes; --/--) which is severe and often results in neonatal death; and hemoglobin H disease (most commonly caused by deletion of 3 alpha-globin genes; --/-alpha) which results in hemolytic anemia, splenomegaly and bone changes." ; obo:SCDO_0000303 "Curation completed by the SCDO curator team: Clair." ; obo:SCDO_0000340 "Origa R, Moi P. Alpha-Thalassemia. 2005 Nov 1 [Updated 2016 Dec 29]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1435/", "http://purl.bioontology.org/ontology/MESH/D017085" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000042" ; oboInOwl:hasDbXref "MESH:D017085" ; oboInOwl:hasExactSynonym "A-Thalassemia", "Alpha-Thalassemia", "Thalassemia Alpha" ; a owl:Class ; rdfs:label "Alpha Thalassemia" ; rdfs:subClassOf obo:NCIT_C35069, obo:OGMS_0000051, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:HP_0005560 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000251 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:EUPATH_0000034 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001386 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0001384 ] . obo:SCDO_0000045 obo:IAO_0000115 "Drugs that selectively bind to and activate alpha adrenergic receptors." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000316" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000045" ; oboInOwl:hasDbXref "MESH:D000316" ; oboInOwl:hasExactSynonym "Adrenergic Alpha Agonists", "Adrenergic Alpha-Agonists", "Alpha Adrenergic Receptor Agonist" ; a owl:Class ; rdfs:label "Alpha-Adrenergic Agents" ; rdfs:subClassOf obo:SCDO_0000067, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000046 obo:IAO_0000115 "A region of chromosome 16 that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. It is responsible for the creation of the alpha parts (roughly half) of the oxygen transport protein Hemoglobin." ; obo:SCDO_0000303 "Request inclusion into relevant ontology perhaps below \"Genetic Locus\"/\"Globin Locus\" (also to be included) in MESH." ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Alpha-Globin Gene Cluster" ; a owl:Class ; rdfs:label "Alpha-Globin Locus" ; rdfs:subClassOf obo:SCDO_0000456 . obo:SCDO_0000049 obo:IAO_0000115 "Methods of pain relief that may be used with or in place of analgesics." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000698" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000049" ; oboInOwl:hasDbXref "MESH:D000698" ; oboInOwl:hasExactSynonym "Analgesias" ; a owl:Class ; rdfs:label "Analgesia" ; rdfs:subClassOf obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000050 obo:IAO_0000115 "A compound capable of relieving pain without the loss of consciousness." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000700" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000050" ; oboInOwl:hasDbXref "MESH:D000700" ; oboInOwl:hasExactSynonym "Analgesic", "Analgesic Agent", "Analgesic Drugs", "Anodynes", "Antinociceptive Agent", "Pain Killers", "Painkiller", "Painkillers" ; a owl:Class ; rdfs:label "Analgesic" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001342 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001369 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001382 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002653 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002829 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003198 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003302 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003418 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0004586 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0010885 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0011868 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0030127 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0100774 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SYMP_0019161 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000053 obo:IAO_0000115 "An adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0002348" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000053" ; oboInOwl:hasDbXref "OAE:0002348" ; a owl:Class ; rdfs:label "Anesthetic Complication AE" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000054 obo:IAO_0000115 "Grayish, brown, or dark red streaks caused by cracks in Bruch's membrane that are histologically characterized by calcium deposition. Angioid streaks are most characteristic of sickle cell anemia and can occur to a lesser extent in other sickle cell syndromes, but not in sickle cell trait." ; obo:SCDO_0000303 "Suggest update to description in DO. Currently no description." ; obo:SCDO_0000340 "Ballas et al 2010 Am J Hematol" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "DOID:13401" ; a owl:Class ; rdfs:label "Angioid Streaks" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000055 obo:IAO_0000115 "A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000806" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000055" ; oboInOwl:hasDbXref "MESH:D000806" ; oboInOwl:hasExactSynonym "ACE", "ACE Inhibitors", "Angiotensin Converting Enzyme", "Angiotensin Converting Enzyme Inhibitors" ; a owl:Class ; rdfs:label "Angiotensin-Converting Enzyme Inhibitors" ; rdfs:subClassOf obo:SCDO_0000067, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003126 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000037 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000796 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000797 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000932 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000056 obo:IAO_0000115 "The respondent's total family income from the last calendar year." ; obo:SCDO_0000303 """Request inclusion into MESH below \"Income\". The PhenX protocol is U.S. specific. Is there one relevant to the African setting?""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Annual Family Income #11101" ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasDbXref "phenX:11100" ; a owl:Class ; rdfs:label "Annual Family Income" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0001090, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000574 ] . obo:SCDO_0000057 obo:IAO_0000115 "Substance that reduces or suppresses inflammation." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000893" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000057" ; oboInOwl:hasDbXref "MESH:D000893" ; oboInOwl:hasExactSynonym "Anti Inflammatories", "Anti Inflammatory Agents", "Anti-Inflammatories", "Anti-Inflammatory Agents", "Anti-Inflammatory Drug", "Antiinflammatories", "Antiinflammatory Agents" ; a owl:Class ; rdfs:label "Anti-Inflammatory Agent" ; rdfs:subClassOf obo:SCDO_0000809, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000132 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001382 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002653 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002725 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002829 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003198 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003302 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003418 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0011868 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0100774 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SYMP_0019161 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000066 obo:IAO_0000115 "Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006633" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000066" ; oboInOwl:hasDbXref "MESH:D006633" ; oboInOwl:hasExactSynonym "Antihistamines", "Histamine Antagonist", "Histamine Antagonists" ; a owl:Class ; rdfs:label "Antihistamine" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001073 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000067 obo:IAO_0000115 "Used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. Among the antihypertensive agents are diuretics; (especially diuretics, thiazide); adrenergic aeta-antagonists; adrenergic alpha-antagonistics; angiotensin-converting enzyme inhibitors; calcium channel blockers; ganglionic blockers; and vasodilator agents." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000959" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000067" ; oboInOwl:hasDbXref "MESH:D000959" ; oboInOwl:hasExactSynonym "Agents, Antihypertensive", "Anti Hypertensive Agent", "Anti-Hypertensives", "Antihypertensive Drug", "Antihypertensive Drugs", "Antihypertensives" ; a owl:Class ; rdfs:label "Antihypertensive Agents" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001129, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002076 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002170 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0100601 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000226 ] . obo:SCDO_0000069 obo:IAO_0000115 "This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Variants in the APOL1 gene can influence susceptibility to end-stage renal disease and Trypanosomiasis (African Sleeping Sickness)." ; obo:SCDO_0000303 "Exists in other ontologies but we have provided a description more relevant to its relationship with SCD." ; obo:SCDO_0000340 "http://www.ncbi.nlm.nih.gov/gene/8542" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; oboInOwl:hasExactSynonym "APO-L", "APOL", "APOL1 Gene", "Apolipoprotein L1 Gene" ; a owl:Class ; rdfs:label "APOL1" ; rdfs:subClassOf obo:SCDO_0000810 . obo:SCDO_0000070 obo:IAO_0000115 "Exercises performed in or underwater for conditioning or rehabilitation (e.g., in injured athletes or patients with joint diseases)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/aquatic+therapy" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Aqua Therapy", "Hydrotherapy" ; a owl:Class ; rdfs:label "Aquatic Rehabilitation" ; rdfs:subClassOf obo:SCDO_0000978 . obo:SCDO_0000071 obo:IAO_0000115 "A hematology assay that measures the acidity (pH) and the levels of oxygen and carbon dioxide in the blood from an artery. This test is used to check how well the lungs are able to move oxygen into the blood and remove carbon dioxide from the blood." ; obo:SCDO_0000340 obo:ERO_0000533 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000071" ; oboInOwl:hasDbXref "ERO:0000533" ; oboInOwl:hasExactSynonym "ABG Test" ; a owl:Class ; rdfs:label "Arterial Blood Gas Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000849 ] . obo:SCDO_0000072 obo:IAO_0000115 "Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D001165" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000072" ; oboInOwl:hasDbXref "MESH:D001165" ; oboInOwl:hasExactSynonym "Arteriovenous Malformations" ; a owl:Class ; rdfs:label "Arteriovenous Malformation" ; rdfs:subClassOf obo:HP_0030680 . obo:SCDO_0000073 obo:IAO_0000115 "A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000073" ; oboInOwl:hasDbXref "MESH:D000077332" ; oboInOwl:hasExactSynonym "Artesunic Acid", "Dihydroartemisinine 12 Alpha Succinate" ; a owl:Class ; rdfs:label "Artesunate" ; rdfs:subClassOf obo:IDOMAL_0000122, obo:SCDO_0001129 . obo:SCDO_0000078 obo:IAO_0000115 "The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)." ; obo:IAO_0100001 obo:SCDO_1000296 ; obo:SCDO_0000303 """Is this term acceptable? If so, request inclusion into relevant ontology""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820201" ; oboInOwl:hasExactSynonym "ASCQ-Me - Quality of Life in SCD", "Sickle Cell Disease Adult Quality of Life Questionnaire Assessment Score" ; a owl:Class ; rdfs:label "deprecated ASCQ-Me Score" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000079 obo:IAO_0000115 "A bioassay to measure levels of aspartate aminotransferase (AST), which is released into the blood following tissue damage." ; obo:SCDO_0000303 "Suggest update to PhenX label (\"Aspartate Aminotransferase Level\") also to NCIT label (from \"Aspartate Aminotransferase Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:811201" ; oboInOwl:hasExactSynonym "AST Blood Test", "Aspartate Transaminase Blood Test", "Serum AST Blood Test" ; a owl:Class ; rdfs:label "Aspartate Aminotransferase Blood Test" ; rdfs:subClassOf obo:NCIT_C74954, obo:SCDO_0000133, obo:SCDO_0000500, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000080 ] . obo:SCDO_0000080 obo:IAO_0000115 "The amount of aspartate aminotransferase present in a specified volume of blood." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "AST Level", "Aspartate Transaminase Level", "Blood Aspartate Transaminase Amount" ; a owl:Class ; rdfs:label "Aspartate Aminotransferase Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000079 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0031956 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000831 ] . obo:SCDO_0000081 obo:IAO_0000115 "A set of 27 questions administered to adults with sickle cell disease (SCD) to determine the quality of care that they have received from health care providers." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Quality of Care\")" ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820101" ; obo:SCDO_0000479 "PhenX protocol: Quality of Care - Adults #820101" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic Patients (Adults with SCD)" ; obo:SCDO_0000486 "These questions are used to assess the patient-reported health care needs and quality of service from health care providers for individuals with chronic conditions such as sickle cell disease (SCD)." ; obo:SCDO_0001222 "18 and older" ; obo:SCDO_1000288 "Suggest update to label" ; dc:creator "SCDO" ; dc:source "Keller, S. D., Yang, M., Treadwell, M. J., Werner, E. M., & Hassell, K. L. (2014). Patient reports of health outcome for adults living with sickle cell disease: Development and testing of the ASCQ-Me item banks. Health and Quality of Life Outcomes, 12(1), 125. doi:10.1186/s12955-014-0125-0" ; oboInOwl:hasExactSynonym "ASCQ-Me Quality of Care Module" ; a owl:Class ; rdfs:label "ASCQ-Me - Quality of Care in SCD" ; rdfs:subClassOf obo:SCDO_0000947 . obo:SCDO_0000082 obo:IAO_0000115 "A planned process with the objective of producing diagnostic information about the material entity that is the evaluant, by physically examining it or its proxies." ; obo:SCDO_0000303 """Possibly too specifiic to this ontology to be included in another ontology? Use structuring of sub-classes within MESH's \"Diagnostic Techniques and Procedures\" and NCIT's \"Diagnostic Procedure\" to inform structuring of terms in this class.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source "http://purl.obolibrary.org/obo/OBI_0000070" ; oboInOwl:hasExactSynonym "Diagnostic Assay", "Diagnostic Method", "Diagnostic Technique", "Diagnostic Test" ; a owl:Class ; rdfs:label "Diagnostic Technique, Method, Test or Assay" ; rdfs:subClassOf obo:SCDO_1000032 . obo:SCDO_0000084 obo:IAO_0000115 "This measure is a magnetic resonance imaging (MRI) method of capturing an individual's heart performance, and is considered the gold standard for capturing ventricular volumes and mass. It is used to detect cardiac abnormalities, such as cardiomyopathies, myocardial fibrosis, and infarction." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. Perhaps in the CPT." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/toolkit_content/supplemental_info/scd_cardio_pulm_renal/measures/Short_Axis_Function_20May2015.doc" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "MRI of Short-Axis Cardiac Function" ; a owl:Class ; rdfs:label "Assessment of Short-Axis Cardiac Function by MRI" ; rdfs:subClassOf obo:NCIT_C16809, obo:SCDO_0000500 . obo:SCDO_0000086 obo:IAO_0000115 "A form of bronchial disorder with three distinct components: airway hyper-responsiveness, airway inflammation, and intermittent airway obstruction. It is characterized by spasmodic contraction of airway smooth muscle, wheezing and dyspnea." ; obo:SCDO_0000303 """Further work: is caused by links to be moved to object property links""", "Include a copy of this term below \"Comorbid Disease\" and/or below \"Respiratory System\"." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D001249" ; obo:SCDO_0000661 "Airway hyper-responsiveness", "Airway inflammation", "Intermittent airway obstruction" ; obo:SCDO_0000662 "It is characterized by spasmodic contraction of airway smooth muscle, wheezing and dyspnea." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000086" ; oboInOwl:hasDbXref "MESH:D001249" ; a owl:Class ; rdfs:label "Asthma" ; rdfs:subClassOf obo:HP_0002086, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000088 obo:IAO_0000115 "A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000088" ; oboInOwl:hasDbXref "MESH:D003876" ; oboInOwl:hasExactSynonym "Atopic Eczema", "Baby Eczema", "Infantile Eczema" ; a owl:Class ; rdfs:label "Atopic Dermatitis" ; rdfs:subClassOf obo:HP_0011123, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ] . obo:SCDO_0000094 obo:IAO_0000115 "This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene." ; obo:SCDO_0000303 "Link to \"Hereditary Persistence of fetal hemoglobin\".", "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.ncbi.nlm.nih.gov/gene/53335" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; oboInOwl:hasExactSynonym "B-Cell CLL/Lymphoma 11A Gene", "B-cell CLL/lymphoma 11A (zinc finger protein)", "B-cell CLL/lymphoma 11A Gene", "BAF Chromatin Remodeling Complex Subunit BCL11A Gene", "BCL-11A Gene", "BCL11A Gene", "Fetal Hemoglobin Quantitative Trait Locus 5", "HBFQTL5" ; a owl:Class ; rdfs:label "BCL11A" ; rdfs:subClassOf obo:SCDO_0000810, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_1000707 ] . obo:SCDO_0000098 obo:IAO_0000115 "One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to oxygen: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or phototrophy (via light reaction); for chemotrophs by their source of chemical energy: chemolithotrophy (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for carbon; nitrogen; etc.; heterotrophy (from organic sources) or autotrophy (from carbon dioxide). They can also be classified by whether or not they stain (based on the structure of their cell walls) with crystal violet dye: gram-negative or gram-positive." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D001419" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000098" ; oboInOwl:hasDbXref "MESH:D001419" ; a owl:Class ; rdfs:label "Bacteria" ; rdfs:subClassOf obo:OBI_0000925 . obo:SCDO_0000102 obo:IAO_0000115 "The BAI is the most widely used instument for measuring anxiety. It consists of 21 items to assess how bothersome a symptom of anxiety has been for the subject over the past month. Scoring the BAI is based on a 0-3 point scale with higher scores indicating severity." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. Could be as a child of \"Symptom Specific Assessment Tool\" in the NCIT." ; obo:SCDO_0000340 "Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893-897." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic Patients" ; obo:SCDO_0000484 "Spanish" ; obo:SCDO_0001222 "17 years and older" ; obo:SCDO_0001335 "yes" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "BAI", "Beck Anxiety Inventory" ; a owl:Class ; rdfs:label "Beck Anxiety Inventory (BAI)" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297 . obo:SCDO_0000104 obo:IAO_0000115 "The Behavior Rating Inventory of Executive Function (BRIEF) is a detailed questionnaire designed to assess executive function behaviors of children and adolescents in the school and home environments. The BRIEF is completed by parents and teachers." ; obo:SCDO_0000303 "Suggest update to label in PhenX." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: #131102" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:131102" ; oboInOwl:hasExactSynonym "BRIEF", "Executive Function - Child" ; a owl:Class ; rdfs:label "Behavior Rating Inventory of Executive Function" ; rdfs:subClassOf obo:SCDO_0001304 . obo:SCDO_0000106 obo:IAO_0000115 "The actions or reactions of a person in response to a situation or stimuli." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Behaviour" ; rdfs:subClassOf obo:SCDO_0000746 . obo:SCDO_0000107 obo:IAO_0000115 "Personal or collective understanding of what the causes (could be predisposing factors, enabling factors, precipitating factors, reinforcing factors, and/or risk factors) are of a certain illness." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source "http://purl.bioontology.org/ontology/MESH/D015984" ; oboInOwl:hasExactSynonym "Beliefs about Causality" ; a owl:Class ; rdfs:comment "Cultural beliefs, such as re-incarnation and witchcraft, may influence notions on causality of sickle cell disease." ; rdfs:label "Beliefs About Causes of Illness" ; rdfs:subClassOf obo:SCDO_0000488 . obo:SCDO_0000108 obo:IAO_0000115 "Personal or collective understanding of what can remedy or treat illness." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps MESH." ; obo:SCDO_1000288 "none" ; dc:creator "SCDO" ; dc:source "http://www.ncbi.nlm.nih.gov/mesh/68003469" ; a owl:Class ; rdfs:label "Beliefs About Remedies and Treatment" ; rdfs:subClassOf obo:SCDO_0000488 . obo:SCDO_0000110 obo:IAO_0000115 "A beta-thalassemia caused by the reduced (beta-) synthesis of the beta globin chains of the hemoglobin (Hb) tetramer." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps DOID." ; obo:SCDO_0000340 "A. Cao and R. Galanello, \"Beta Thalassemia\", Genetics in Medicine, Vol. 12, No. 2, 2010, pp. 61 76. doi:10.1097/GIM.0b013e3181cd68ed" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Beta - Thalassemia", "Beta Minus-Thalassemia", "Beta- Thalassemia", "Beta-Minus-Thalassemia" ; a owl:Class ; rdfs:label "Beta Minus Thalassemia" ; rdfs:subClassOf obo:SCDO_0000111, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_0001765 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000976 ] . obo:SCDO_0000111 obo:IAO_0000115 "A hemoglobinopathy characterized by the reduced (beta plus) or absent (beta zero) synthesis of the beta globin chains of hemoglobin, resulting in variable outcomes ranging from severe anemia to clinically asymptomatic individuals." ; obo:SCDO_0000303 """Suggest update to description in DOID. Include a \"Dominant Beta-Thalassemia\" sub-class? (see Orphanet)""" ; obo:SCDO_0000340 "A. Cao and R. Galanello, \"Beta Thalassemia\", Genetics in Medicine, Vol. 12, No. 2, 2010, pp. 61 76. doi:10.1097/GIM.0b013e3181cd68ed", "Origa R. Beta-Thalassemia. 2000 Sep 28 [Updated 2018 Jan 25]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1426/", "http://en.wikipedia.org/wiki/Beta_thalassemia", "http://purl.obolibrary.org/obo/DOID_12241" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "DOID:12241" ; oboInOwl:hasExactSynonym "Beta Thalassemias", "Beta Type Thalassemia", "Beta-Thalassemia", "Beta-Thalassemias", "Hemoglobin F Disease", "Mediterranean Anemia" ; a owl:Class ; rdfs:label "Beta Thalassemia" ; rdfs:subClassOf obo:NCIT_C35069, obo:OGMS_0000051, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_0007624 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:HP_0011906 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000240 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0000112 obo:IAO_0000115 "A homozygous (B+/B+) or compound heterozygous (B0/B+) form of beta-thalassemia characterized by mild to moderate anemia which does not or only occasionally requires transfusion." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000112" ; oboInOwl:hasDbXref "ORPHA:231222" ; oboInOwl:hasExactSynonym "B+/B+", "B0/B+", "Beta-Thalassemia Intermedia", "Thalassemia Intermedia" ; a owl:Class ; rdfs:label "Beta Thalassemia Intermedia" ; rdfs:subClassOf obo:SCDO_0000251, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000952 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001640 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0002149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C78393 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000685 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006905 ] . obo:SCDO_0000113 obo:IAO_0000115 "A severe early-onset form of beta thalassemia characterized by severe anemia requiring regular red blood cell transfusions." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000113" ; oboInOwl:hasDbXref "ORPHA:231214" ; oboInOwl:hasExactSynonym "B0/B0", "BT Major", "Beta-Thalassemia Major", "Cooley Anemia", "Cooley's Anemia", "Mediterranean Anemia", "Thalassemia Major" ; a owl:Class ; rdfs:label "Beta Thalassemia Major" ; rdfs:subClassOf obo:SCDO_0000251, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000819 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000821 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000823 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0000939 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0002007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0012418 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:IDO_0000586 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:MP_0002412 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C2890 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C3439 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C78393 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000465 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000685 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000943 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0005167 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006905 ] . obo:SCDO_0000114 obo:IAO_0000115 "The inheritance of only one mutated beta-globin allele (beta+ or beta0)." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Perhaps below \"clinical subtype\" in Orphanet. The exact synonym \"B+/B\" has been changed to \"B-/B\", as per the change in convention from \"Beta Plus Thalassemia\" to \"Beta Minus Thalassemia\".""" ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Beta_thalassemia" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "B-/B", "B0/B", "Beta Thalassemia Minor", "Beta-Thalassemia Trait", "Heterozygosity for Beta-Thalassemia", "Heterozygous Beta-Thalassemia" ; a owl:Class ; rdfs:label "Beta Thalassemia Trait" ; rdfs:subClassOf obo:SCDO_0000251, obo:SCDO_0000551, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C95504 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_0009731 ] . obo:SCDO_0000115 obo:IAO_0000115 "Beta-zero thalassemia is a form of beta-thalassemia in which beta-globin chain synthesis is absent. The clinical phenotype is often that of transfusion-dependant beta thalassemia major, however modifying factors may ameliorate the symptoms of severe anemia (Cao & Gallanelo, 2010)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps DOID." ; obo:SCDO_0000340 "A. Cao and R. Galanello, \"Beta Thalassemia\", Genetics in Medicine, Vol. 12, No. 2, 2010, pp. 61 76. doi:10.1097/GIM.0b013e3181cd68ed" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Beta 0 Thalassemia", "Beta Zero-Thalassemia", "Beta-Zero-Thalassemia", "Beta0 Thalassemia", "Hb Beta Zero-Thalassemia", "Hb F only" ; a owl:Class ; rdfs:label "Beta Zero Thalassemia" ; rdfs:subClassOf obo:SCDO_0000111, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001329 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0008888 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_0002475 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000241 ] . obo:SCDO_0000116 obo:IAO_0000115 "A globin locus composed of five genes located on a short 45 kb region of chromosome 11. The order of genes in this cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. It is responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin." ; obo:SCDO_0000303 "Request inclusion into relevant ontology perhaps below \"Genetic Locus\"/\"Globin Locus\" (also to be included) in MESH." ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Beta-Globin Cluster", "Beta-Globin Gene Cluster", "HBB Locus" ; a owl:Class ; rdfs:label "Beta-Globin Locus" ; rdfs:subClassOf obo:SCDO_0000456 . obo:SCDO_0000117 obo:IAO_0000115 "Defined arrays of polymorphic gene sites that are inherited together across the genetic vicinity of the beta-globin gene or gene cluster on chromosome 11." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Nagel, et. al. NEngl J Med. 1985 Apr 4;312(14):880-4" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Beta-Globin Haplotypes", "Beta-Haplotypes", "Beta-S Haplotype", "Beta-S Haplotypes" ; a owl:Class ; rdfs:label "Beta-Globin Haplotype" ; rdfs:subClassOf obo:NCIT_C63547, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_1000707 ] . obo:SCDO_0000119 obo:IAO_0000115 "A bioassay to measure levels of bilirubin, a yellow substance found in bile produced when the liver breaks down old red blood cells." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Bilirubin Level\")." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:810901" ; a owl:Class ; rdfs:label "Bilirubin Blood Test" ; rdfs:subClassOf obo:NCIT_C74954, obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:CMO_0000123 ] . obo:SCDO_0000120 obo:IAO_0000115 "An analytical in vitro procedure used to detect, quantify and/or study the binding or activity of a biological molecule, such as an enzyme." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "http://www.nature.com/subjects/biochemical-assays" ; obo:SCDO_1000288 "Negligable" ; a owl:Class ; rdfs:label "Biochemical Assay" ; rdfs:subClassOf obo:SCDO_0000216 . obo:SCDO_0000122 obo:IAO_0000115 "A biological factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Biological Disease Modifier" ; rdfs:subClassOf obo:SCDO_0000391 . obo:SCDO_0000123 obo:IAO_0000115 "The country in which the respondent was born." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocols&id=010200" ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasExactSynonym "Place of Birth" ; a owl:Class ; rdfs:label "Birthplace" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_0000124 obo:IAO_0000115 "The country in which the respondent's biological father was born." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Birthplace of Biological Father" ; rdfs:subClassOf obo:SCDO_0000129 . obo:SCDO_0000125 obo:IAO_0000115 "The country in which the respondent's biological mother was born." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Birthplace of Biological Mother" ; rdfs:subClassOf obo:SCDO_0000129 . obo:SCDO_0000126 obo:IAO_0000115 "The country or countires in which the respondent's biological grandparents were born." ; obo:SCDO_0000303 """Request inclusion into relevant ontology There is a protocol in PhenX but it is US specific.""" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Birthplace of Grandparents" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_0000127 obo:IAO_0000115 "The country in which the respondent's biological maternal (on the mother's side of the family) grandfather was born." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Birthplace of Maternal Grandfather" ; rdfs:subClassOf obo:SCDO_0000126 . obo:SCDO_0000128 obo:IAO_0000115 "The country in which the respondent's biological maternal (on the mother's side of the family) grandmother was born." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Birthplace of Maternal Grandmother" ; rdfs:subClassOf obo:SCDO_0000126 . obo:SCDO_0000129 obo:IAO_0000115 "The country or countires in which the respondent's biological parents were born." ; obo:SCDO_0000303 """Request inclusion into relevant ontology There is a protocol in PhenX but it is US specific.""" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Birthplace of Parents" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_0000130 obo:IAO_0000115 "The country in which the respondent's biological paternal (on the father's side of the family) grandfather was born." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Birthplace of Paternal Grandfather" ; rdfs:subClassOf obo:SCDO_0000126 . obo:SCDO_0000131 obo:IAO_0000115 "The country in which the respondent's biological paternal (on the father's side of the family) grandmother was born." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Birthplace of Paternal Grandmother" ; rdfs:subClassOf obo:SCDO_0000126 . obo:SCDO_0000132 obo:IAO_0000115 "Black lesions in the retina that form at the border of perfused and nonperfused retina that are caused by the migration of hyperplastic retinal pigment epithelial cells into sensory retina. The sensory retina surrounding the lesion is atrophic." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "Ballas et al 2010 Am J Hematol" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Black Sunburst Lesion" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C75583 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000835 ] . obo:SCDO_0000133 obo:IAO_0000115 "Test used in the analysis of the hemic system." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006403" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000133" ; oboInOwl:hasDbXref "MESH:D006403" ; oboInOwl:hasExactSynonym "Blood Assay", "Blood Tests", "Hematologic Test", "Hematologic Tests", "Hematological Test", "HematologyTest" ; a owl:Class ; rdfs:label "Blood Test" ; rdfs:subClassOf obo:SCDO_0000902, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000138 obo:IAO_0000115 "The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in plasmapheresis and types of cytapheresis; (plateletpheresis and leukapheresis) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016913" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000138" ; oboInOwl:hasDbXref "MESH:D016913" ; a owl:Class ; rdfs:label "Blood Component Transfusion" ; rdfs:subClassOf obo:SCDO_0000147 . obo:SCDO_0000139 obo:IAO_0000115 "Test to determine the presence of blood infection (e.g. sepsis; bacteremia)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000139" ; oboInOwl:hasDbXref "MESH:D000071997" ; oboInOwl:hasExactSynonym "BC", "Culture Blood", "Haemoculture", "Hemoculture" ; a owl:Class ; rdfs:label "Blood Culture" ; rdfs:subClassOf obo:SCDO_0000133 . obo:SCDO_0000147 obo:IAO_0000115 "The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D001803" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000147" ; dc:source , "Radha Raghupathy, Deepa Manwani, and Jane A. Little, “Iron Overload in Sickle Cell Disease,” Advances in Hematology, vol. 2010, Article ID 272940, 9 pages, 2010. doi:10.1155/2010/272940" ; oboInOwl:hasDbXref "MESH:D001803" ; oboInOwl:hasExactSynonym "Blood Transfusions" ; a owl:Class ; rdfs:comment """The major and unavoidable complication of transfusions in sickle cell disease is iron overload. Transfusion is well-defined as prophylaxis (stroke) and as therapy (acute chest syndrome and stroke) for major complications of sickle cell disease and has been instituted, based on less conclusive data, for a range of additional complications, such as priapism, vaso-occlusive crises, leg ulcers, pulmonary hypertension, and during complicated pregnancies.""" ; rdfs:label "Blood Transfusion" ; rdfs:subClassOf obo:SCDO_0000922, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001789 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0004727 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155312 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C92853 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C95504 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000519 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000530 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000812 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000972 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001064 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_1000077 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_1000078 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000149 obo:IAO_0000115 "The distance from the sole to the crown of the head with body standing on a flat surface and fully extended." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_0004339" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000149" ; oboInOwl:hasDbXref "EFO:0004339" ; oboInOwl:hasExactSynonym "Height", "Height/Length", "Length/Height" ; a owl:Class ; rdfs:label "Body Height" ; rdfs:subClassOf obo:CMO_0000011 . obo:SCDO_0000152 obo:IAO_0000115 "The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms." ; obo:SCDO_0000303 "Add these terms from PhenX?: -- - Weight Loss/Gain" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000152" ; oboInOwl:hasDbXref "MESH:D001835" ; oboInOwl:hasExactSynonym "Weight" ; a owl:Class ; rdfs:label "Body Weight" ; rdfs:subClassOf obo:CMO_0000011 . obo:SCDO_0000155 obo:IAO_0000115 "An abnormal hardening or increased density of bone tissue." ; obo:IAO_0100001 obo:SCDO_0000629 ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000155" ; dc:source "Segen's Medical Dictionary. S.v. \"bone sclerosis.\" Retrieved April 30 2019 from https://medical-dictionary.thefreedictionary.com/bone+sclerosis" ; oboInOwl:hasDbXref "MESH:D010026" ; oboInOwl:hasExactSynonym "Bone Scleroses", "Osteoscleroses", "Osteosclerosis" ; a owl:Class ; rdfs:comment "The bone is more radiopaque than normal on a plain film." ; rdfs:label "deprecated-Bone Sclerosis" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000156 obo:IAO_0000115 "A noninvasive method to assess the endothelial dysfunction in the brachial artery." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Endothelial_dysfunction" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "BAUI" ; a owl:Class ; rdfs:label "Brachial Artery Ultrasound Imaging" ; rdfs:subClassOf obo:NCIT_C17230, obo:SCDO_0001228 . obo:SCDO_0000161 obo:IAO_0000115 "Voltages between parts of the brain that are detectable with an electroencephalograph." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000161" ; oboInOwl:hasDbXref "CRISP:0487-1238" ; oboInOwl:hasExactSynonym "Brain Electrophysiological Activity", "Brain Oscillography", "EEG activity" ; a owl:Class ; rdfs:label "Brain Electrical Activity" ; rdfs:subClassOf obo:SCDO_0000728, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000420 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0000419 ] . obo:SCDO_0000162 obo:IAO_0000115 "An episode of severe pain that occurs with rapid onset even when pain-control medication is being used. Breakthrough pain can occur spontaneously or in relation to a specific activity, and can last from a few seconds to a few hours." ; obo:SCDO_0000340 , "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014" ; oboInOwl:hasDbXref "NCIT:C9203" ; a owl:Class ; rdfs:comment "There are currently no data that clearly describe or can be used to define breakthrough pain in SCD." ; rdfs:label "Breakthrough Pain" ; rdfs:subClassOf obo:SCDO_0000233, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000163 obo:IAO_0000115 "The Brief IPQ has 9 items, 8 new items from the IPQ plus a causal question. All of the items except the causal question are rated using a 0-to-10-response scale. Five of the items assess Cognitive Illness Representations: Consequences (Item 1), Timeline (Item 2), Personal Control (Item 3), Treatment Control (Item 4), and Identity (Item 5). Two of the items assess Emotional Representations: Concern (Item 6) and Emotions (Item 8). One item assesses Illness Comprehensibility (Item 7). Assessment of the Causal Representation is by an open-ended response item adapted, which asks patients to list the three most important causal factors in their illness (Item 9). Responses to the causal item can be grouped into categories such as stress, lifestyle, hereditary, etc, determined by the particular illness studied, and categorical analysis can then be performed." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Broadbent E, Petrie KJ, Main J, Weinman, J. (2006). The brief illness perception questionnaire. Journal of Psychosomatic Research, 60, 631-637." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic Patients" ; obo:SCDO_0000484 "Many" ; obo:SCDO_0001033 "Good psychometric properties, widely used, has been translated into several languages." ; obo:SCDO_0001222 "Adults" ; obo:SCDO_0001335 "yes" ; obo:SCDO_1000288 "None" ; dc:source "Broadbent E, Petrie KJ, Main J, Weinman, J. (2006). The brief illness perception questionnaire. Journal of Psychosomatic Research, 60, 631-637." ; oboInOwl:hasExactSynonym "B-IPQ", "Brief Illness Perception Questionnaire" ; a owl:Class ; rdfs:label "Brief Illness Perception Questionnaire (B-IPQ)" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0000164 obo:IAO_0000115 "Brief RCOPE is a 14-item instrument that measures religious coping with major life stressors. Responses on the Brief RCOPE indicate the frequency with which participants have used R/S coping behaviors on a Likert scale of 1 (not at all) to 4 (a great deal.) The scale has been used to examine positive and negative religious coping, including in teens with SCD." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Pargament K, Koenig H, Perez L. The many methods of religious coping: development and initial validation of the RCOPE. J Clin Psychol. 2000;56:519-543." ; obo:SCDO_0000481 "Self; Proxy (Parent report)" ; obo:SCDO_0000482 "Children with SCD and their parents." ; obo:SCDO_0001033 "Demonstrated validity in SCD studies." ; obo:SCDO_0001222 "Children and adults" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "Pargament K, Koenig H, Perez L. The many methods of religious coping: development and initial validation of the RCOPE. J Clin Psychol. 2000;56:519-543." ; a owl:Class ; rdfs:label "Brief RCOPE" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0000165 obo:IAO_0000115 "The improvement of forced expiratory volume in 1 second (FEV1) after inhalation of beta2-agonists and is typically measured as the change in airflow after the administration of short-acting beta2-adrenergic agonists (SABAs)." ; obo:SCDO_0000303 "Suggest that the description be updated in PhenX (https://www.phenxtoolkit.org/protocols/view/90301)" ; obo:SCDO_0000340 "Bauer S, Park HN, Seo HS, et al. Assessment of bronchodilator responsiveness following methacholine-induced bronchoconstriction in children with asthma. Allergy Asthma Immunol Res. 2011;3(4):245-50." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasExactSynonym "BDR" ; a owl:Class ; rdfs:label "Bronchodilator Responsiveness" ; rdfs:subClassOf obo:CMO_0000094, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000166 ] . obo:SCDO_0000166 obo:IAO_0000115 "A test to assess an individual's change in pulmonary function in response to inhaled bronchodilator medications." ; obo:SCDO_0000303 """Suggest update to label in PhenX (from \"Bronchodilator Responsiveness (BDR)\") Can also suggest inclusion in MESH below \"Respiratory Function Tests\"""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Bronchodilator Responsiveness (BDR) #90301" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:90301" ; oboInOwl:hasExactSynonym "BDR Test", "Bronchodilator Responsiveness Testing" ; a owl:Class ; rdfs:label "Bronchodilator Responsiveness Test" ; rdfs:subClassOf obo:SCDO_0000942, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C85397 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000165 ] . obo:SCDO_0000182 obo:IAO_0000115 "A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of proteins; nucleic acids; and carbohydrates. (Segen, Dictionary of Modern Medicine, 1992)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D019075" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000182" ; oboInOwl:hasDbXref "MESH:D019075" ; oboInOwl:hasExactSynonym "Capillary Electrophoreses", "Capillary Zone Electrophoreses", "Capillary Zone Electrophoresis" ; a owl:Class ; rdfs:label "Capillary Electrophoresis" ; rdfs:subClassOf obo:SCDO_0000424 . obo:SCDO_0000183 obo:IAO_0000115 "An instrument which, by means of a cathode-ray oscillograph, projects an electrocardiographic record on a luminous screen." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "http://encyclopedia2.thefreedictionary.com/cardioscope" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Cardioscope" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000417 ] . obo:SCDO_0000187 obo:IAO_0000115 "'Anatomical system that has as its parts the heart and blood vessels. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0002245 ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/UBERON_0004535" ; oboInOwl:hasDbXref "UBERON:0004535" ; oboInOwl:hasExactSynonym "CV system" ; a owl:Class ; rdfs:label "deprecated Cardiovascular System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000188 obo:IAO_0000115 "'Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D002363" ; oboInOwl:hasDbXref "MESH:D002363" ; oboInOwl:hasExactSynonym "Case Histories", "Case Studies", "Case Study" ; a owl:Class ; rdfs:label "obsolete Case Reports" ; rdfs:subClassOf obo:SCDO_0000941 ; owl:deprecated true . obo:SCDO_0000189 obo:IAO_0000115 "Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group." ; obo:SCDO_0000303 "Suggest update to description in MESH" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016022" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D016022" ; oboInOwl:hasExactSynonym "Case-Referrent Studies" ; a owl:Class ; rdfs:label "Case-Control Studies" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000190 obo:IAO_0000115 "A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity." ; obo:SCDO_0000303 "Add info (rdfs:comment) about how catheters are used in different therapeutics. -- -- Link relevant Therapeutics term(s) to this term via \"has medical device\"." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D057785" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000190" ; oboInOwl:hasDbXref "MESH:D057785" ; oboInOwl:hasExactSynonym "Cannula", "Cannulas", "Catheters" ; a owl:Class ; rdfs:label "Catheter" ; rdfs:subClassOf obo:SCDO_0000376, obo:SCDO_0001150, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:NCIT_C80411 ] . obo:SCDO_0000191 obo:IAO_0000115 "A drug adverse event that is caused by a drug administration. Here a causal effect is established between the drug administration and the adverse event." ; obo:SCDO_0000303 "Suggest definition replaced in OAE. Currenlty it's shown as the definition editor." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000095" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "OAE:0000095" ; a owl:Class ; rdfs:label "Causal Adverse Drug Event" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000192 obo:IAO_0000115 "A causal adverse drug event that is induced by a drug-drug interaction." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000179" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000192" ; oboInOwl:hasDbXref "OAE:0000179" ; a owl:Class ; rdfs:label "Causal Adverse Drug Event Due to Drug-Drug Interaction" ; rdfs:subClassOf obo:SCDO_0000191 . obo:SCDO_0000193 obo:IAO_0000115 "A causal adverse drug event that is induced by a food-drug interaction." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000180" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000193" ; oboInOwl:hasDbXref "OAE:0000180" ; a owl:Class ; rdfs:label "Causal Adverse Drug Event Due to Food-Drug Interaction" ; rdfs:subClassOf obo:SCDO_0000191 . obo:SCDO_0000194 obo:IAO_0000115 "A causal adverse drug event that is induced by genetic predisposition." ; obo:SCDO_0000303 "Suggest small typo to be fixed in OAE." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000181" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "OAE:0000181" ; a owl:Class ; rdfs:label "Causal Adverse Drug Event Due to Genetic Predisposition" ; rdfs:subClassOf obo:SCDO_0000191 . obo:SCDO_0000195 obo:IAO_0000115 "A causal adverse drug event due to genetic predisposition that is specifically induced by SNP." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000182" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000195" ; oboInOwl:hasDbXref "OAE:0000182" ; a owl:Class ; rdfs:label "Causal Adverse Drug Event Due to SNP" ; rdfs:subClassOf obo:SCDO_0000194 . obo:SCDO_0000198 obo:IAO_0000115 "The determination of the amount of free hemoglobin present in a sample." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Free Hemoglobin Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C127617" ; oboInOwl:hasExactSynonym "Cell Free Hemoglobin Assay", "Cell Free Hemoglobin Blood Assay", "Cell Free Hemoglobin Test", "Free Hemoglobin Blood Test", "HGBFR Test" ; a owl:Class ; rdfs:label "Cell Free Hemoglobin Blood Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000199 ] . obo:SCDO_0000199 obo:IAO_0000115 "The level of hemoglobin external to erythrocytes in a biological specimen." ; obo:SCDO_0000303 """Request inclusion into relevant ontology If wanting to include \"Plasma Hemoglobin Level\" in the future, see CMO:0000588 for a description. synonyms: Plasma Free Hemoglobin (PFHb) Level, Plasma Hemoglobin Level.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Cell Free Haemoglobin Level", "Cell Free Hemoglobin Concentration", "Extracellular Hb Level", "Extracellular Hemoglobin Level", "HGBFR Level" ; a owl:Class ; rdfs:label "Cell Free Hemoglobin Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000198 ] . obo:SCDO_0000206 obo:IAO_0000115 "Cerebral collateral circulation is a subsidiary vascular network which is dynamically recruited after arterial occlusion and may provide residual blood flow to ischemic areas." ; obo:SCDO_0000303 """The description doesn't actually describe the term. Needs revision. Perhaps: Blood flow through cerebral collateral circulation, a subsidiary vascular network which is dynamically recruited after arterial occlusion and which may provide residual blood flow to ischemic areas. Suggest inclusion into CMO, below \"circulation measurement\".""" ; obo:SCDO_0000340 """Cerebral collateral circulation in experimental ischemic stroke. Elisa Cuccione, Giada Padovano, Alessandro Versace, Carlo Ferrarese, Simone Beretta. Exp Transl Stroke Med. 2016; 8: 2. Published online 2016 Mar 1. doi: 10.1186/s13231-016-0015-0 PMCID: PMC4772465""" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Cerebral Collateral Circulation" ; a owl:Class ; rdfs:label "Cerebral Collateral Flow" ; rdfs:subClassOf obo:SCDO_0000213, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001166 ] . obo:SCDO_0000208 obo:IAO_0000115 "A test of how well the cerebrum is functioning." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Cerebral Function Test" ; a owl:Class ; rdfs:label "Cerebral Function Assay" ; rdfs:subClassOf obo:SCDO_0000902 . obo:SCDO_0000213 obo:IAO_0000115 "The movement and the forces involved in the movement of the blood through the blood vessels in the brain." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Perhaps replace with \"cerebral blood flow measurement\" from the EFO?""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source , ; a owl:Class ; rdfs:label "Cerebrovascular Hemodynamics" ; rdfs:subClassOf obo:CMO_0000195 . obo:SCDO_0000216 obo:IAO_0000115 "The analysis of a sample material, called an analyte, using a set of chemical procedures." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "http://www.reference.com/science/chemical-assay-80cfe6f498d34be5" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Chemical Assay" ; rdfs:subClassOf obo:SCDO_0000082 . obo:SCDO_0000217 obo:IAO_0000115 "A medical imaging assessment of the chest wall, airways, lungs, pulmonary vessels, heart, mediastinum, and pleura." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000217" ; oboInOwl:hasDbXref "phenX:810201" ; oboInOwl:hasExactSynonym "Chest Radiograph" ; a owl:Class ; rdfs:label "Chest X-Ray" ; rdfs:subClassOf obo:SCDO_0000963, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:OBI_0001138 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000218 obo:IAO_0000115 "The Child Health Questionnaire (CHQ) is a family of general quality of life surveys that measures 14 unique physical and psychosocial concepts. The parent form is available in 2 lengths - the CHQ-PF50 and the CHQ-PF28. The child self-reported version of the CHQ consists of 87 items (CHQ-CF87)." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self, Proxy" ; obo:SCDO_0000482 "Healthy Children; Children with Medical Conditions" ; obo:SCDO_0000484 "French, isiXhosa, isiZulu, Portuguese, Punjabi, Sesotho, Temil, Telugu, Gujarati" ; obo:SCDO_0001033 "Demonstrated validity with SCD populations; at least two publications using the measure in SCD." ; obo:SCDO_0001222 "5 to 18 years (child report 10 - 18 years; parent report 5 - 18 years)" ; obo:SCDO_0001335 "yes" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; dc:source "Landgraf, J. M., Abetz, L., and Ware, J. E. (1996). Child health questionnaire (CHQ): A user's manual (1st Ed.). Boston, M.A.: The Health Institute, New England Medical Center.", "Panepinto JA, O'Mahar KM, DeBaun MR, Rennie KM, Scott JP. Validity of the child health questionnaire for use in children with sickle cell disease. J Pediatr Hematol Oncol. 2004 Sep;26(9):574-8.", "Wrotniak BH, Schall JI, Brault ME, Balmer DF, Stallings VA. Health-related quality of life in children with sickle cell disease using the child health questionnaire. J Pediatr Health Care. 2014 Jan-Feb;28(1):14-22. doi: 10.1016/j.pedhc.2012.09.004. Epub 2012 Nov 8." ; oboInOwl:hasExactSynonym "CHQ", "Child Health Questionnaire" ; a owl:Class ; rdfs:label "Child Health Questionnaire (CHQ)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0000219 obo:IAO_0000115 "A parent's highest level of education obtained, as reported by the child." ; obo:SCDO_0000303 """Request inclusion into MESH below \"Current Educational Attainment\" (also to be suggested), below \"Socioeconomic Factors\". Also suggest inclusion in the EFO, below measurement.""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Child-Reported Parental Education Attainment #210201" ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasDbXref "phenX:210201" ; a owl:Class ; rdfs:label "Child-Reported Parental Education Attainment" ; rdfs:subClassOf obo:SCDO_0000305, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000220 obo:IAO_0000115 "The CDI-2 is a 27-item self-report scale that helps to assess cognitive, affective and behavioral signs of depression in children and adolescents. Each item is scored on a scale from 0 to 2." ; obo:SCDO_0000303 "Check and show which source was used for the description and whether the description was adapted from the source.", "Request inclusion into relevant ontology. Could be as a child of \"Symptom Specific Assessment Tool\" in the NCIT." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic Patients" ; obo:SCDO_0001222 "7 to 17 years" ; obo:SCDO_0001335 "yes" ; obo:SCDO_1000288 "None" ; dc:source "Kovacs, M. (1985). The Children's Depression, Inventory (CDI). Psychopharmacology Bulletin, 21, 995-998." ; oboInOwl:hasExactSynonym "CDI 2", "CDI-2", "Children's Depression Inventory 2", "Children's Depression Inventory-2" ; a owl:Class ; rdfs:label "Children's Depression Inventory 2 (CDI 2)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0000221 obo:IAO_0000115 "A measure that seeks to determine the extent to which children and adolescents believe their own health-related behaviors will influence their health. It is a 20 item scale that contains 3 additional practice items and is a yes or no format. It contains 3 factors: belief in internality, belief in powerful others and belief in chance. There is a shorter 9-item version of the scale which is comparable to the full version and adapted for use in Egyptian children." ; obo:SCDO_0000340 "Abdel Gawwad E, Ahmed MH, Kamal MM. Developing and testing of an Egyptian version of Children's Health Locus of Control scale. J Egypt Public Health Assoc. 1999; 74(1-2):139-73.", "Deaux EB. Health Locus of Control in Chukotka children. Alaska Med. 1992 Jul-Sep; 34(3):135-9.", "Parcel G.S. and Meyer M.P. (1978) Development of an instrument to measure children's health locus of control. Health Education Monographs, 6, 149-159." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Healthy Children; Children with Medical Conditions" ; obo:SCDO_0000484 "English, Russian, a 9- item shorter Egyptian version" ; obo:SCDO_0001033 "Has adequate reliability, construct validity and internal consistency." ; obo:SCDO_0001222 "Children and Adolescents" ; obo:SCDO_0001335 "no" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasExactSynonym "CHLC", "Children's Health Locus of Control Scale" ; a owl:Class ; rdfs:label "Children's Health Locus of Control Scale (CHLC)" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0000222 obo:IAO_0000115 "Surgical removal of the gallbladder." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D002763" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000222" ; oboInOwl:hasDbXref "MESH:D002763" ; oboInOwl:hasExactSynonym "Cholecystectomies" ; a owl:Class ; rdfs:label "Cholecystectomy" ; rdfs:subClassOf obo:SCDO_0001129, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000225 obo:IAO_0000115 "A condition that co-exists or follows from sickle cell disease and that has a slow, creeping onset, slow progress and long continuance of disease manifestations." ; obo:SCDO_0000303 "Probably too specific to warrant inclusion into anther ontology.", "Used info in \"Evidence-Based Management of Sickle Cell Disease, Expert Panel Report, 2014\" to link to relevant phenotypes." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "http://purl.bioontology.org/ontology/MESH/Q000150", "http://purl.obolibrary.org/obo/HP_0011010" ; a owl:Class ; rdfs:label "Chronic Complications of Sickle Cell Disease" ; rdfs:subClassOf obo:NCIT_C2959, obo:SCDO_0000895 . obo:SCDO_0000226 obo:IAO_0000115 "Chronic kidney disease (CKD) is defined as either having a glomerular filtration rate (GFR) of <60 mL/min/1.73 mL for >3 months with or without kidney damage or having evidence of kidney damage for 3 months, with or without decreased GFR." ; obo:SCDO_0000303 "Suggest update to description in DO (currently no definition)." ; obo:SCDO_0000340 "NHLBI SCD New guidelines 2014." ; obo:SCDO_0000468 "When assessed by albuminuria, often presents in second decade of life in sickle cell disease and prevalence increases with age." ; obo:SCDO_0000472 "CKD is classified using a combination of GFR and ACR categories" ; obo:SCDO_0000661 "Sickle cell disease, hypertension, diabetes, polycystic kidney disease, glomerulonephritis, various other causes." ; obo:SCDO_0000662 "Reduced glomerular filtration, elevated creatinine, anemia, bone disease, uremia." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; dc:source , "NHLBI SCD New guidelines 2014." ; oboInOwl:hasDbXref "DOID:784" ; oboInOwl:hasExactSynonym "CKD", "Chronic Kidney Injury", "Chronic Renal Failure" ; a owl:Class ; rdfs:comment "Evidence of kidney damage includes pathologic abnormalities or markers of kidney damage (i.e., proteinuria) independent of cause. Kidney disease severity is classified into five stages according to the level of GFR and presence of albuminuria." ; rdfs:label "Chronic Kidney Disease" ; rdfs:subClassOf obo:HP_0000084, obo:SCDO_0001334, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001205 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001206 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000983 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000985 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0000310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0000457 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001210 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001212 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000227 obo:IAO_0000115 "Is a long-term condition where the kidneys don't work as well as they should." ; obo:IAO_0100001 obo:SCDO_0000226 ; obo:SCDO_0000303 "There is conflicting positioning of this term in different ontologies. Need an expert to decide descriptions and positioning of this and related terms." ; oboInOwl:hasExactSynonym "CKD" ; a owl:Class ; rdfs:label "deprecated-Chronic Kidney Injury" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000228 obo:IAO_0000115 "Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014" ; obo:SCDO_1000288 "Few but definitions not freely available" ; a owl:Class ; rdfs:label "Chronic Neuropathic Pain" ; rdfs:subClassOf obo:SCDO_0000233, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C62005 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C64625 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000229 obo:IAO_0000115 "This pain occurs in a specific tissue or organ and is usually described as constant and deep, nagging, and achy in nature." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Chronic Pain in a Specific Tissue or Organ" ; rdfs:subClassOf obo:SCDO_0000233 . obo:SCDO_0000230 obo:IAO_0000115 "The only complaint is the patient's self-report of pain that does not go away." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014", "http://doi.org/10.1182/blood-2012-04-383430" ; obo:SCDO_1000288 "None" ; dc:source "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014" ; oboInOwl:hasExactSynonym "Intractable Chronic Pain Without Obvious Pathology" ; a owl:Class ; rdfs:comment """This type of chronic sickle cell pain may be an extension of recurrent acute painful episodes. Therefore, early and aggressive intervention in treating acute sickle cell pain may reduce the development of chronic pain.""" ; rdfs:label "Chronic Pain often Unclear Etiology" ; rdfs:subClassOf obo:SCDO_0000233 . obo:SCDO_0000232 obo:IAO_0000115 "Restrictive lung disease is a category of extrapulmonary, pleural, or parenchymal respiratory diseases that restrict lung expansion, resulting in a decreased lung volume, an increased work of breathing, and inadequate ventilation and/or oxygenation. Pulmonary function test demonstrates a decrease in the forced vital capacity." ; obo:SCDO_0000303 """The description does not seem complete as it does not address the \"chronic\" aspect. Request inclusion into relevant ontology Wikipedia was used as the description source. Perhaps rather use NCIT's \"Restrictive Lung Disease\", and then use wikipedia as source for additional info. Did not find \"Chronic Restrictive Lung Disease\" in ontologies, but did find \"Chronic Obstructive Lung Disease\"...perhaps there was confusion between these terms when giving the name?""" ; obo:SCDO_0000340 obo:HP_0002091 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Chronic Restrictive Ventilatory Defect", "Restrictive Lung Disease" ; a owl:Class ; rdfs:label "Chronic Restrictive Lung Disease" ; rdfs:subClassOf obo:HP_0002086, obo:SCDO_0000954, obo:SCDO_0001334, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0000233 obo:IAO_0000115 "Persistent pain in sickle cell disease. In sickle cell disease, persistent pain (pain that has lasted longer than 3 to 6 months) no longer serves as a warning sign. However, the time distinction is arbitrary and the condition may be difficult to distinguish from frequently recurring acute pain. Chronic pain may occur with objective signs of avascular necrosis, arthropathy, arthritis, leg ulcers or vertebral body collapse, or without objective signs, due to neuroplasticity of the peripheral nervous system." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 obo:HP_0012532, "SCD Management guidelines - Tanzania" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014" ; oboInOwl:hasExactSynonym "SCD-Associated Chronic Pain" ; a owl:Class ; rdfs:label "Chronic Sickle Cell Pain" ; rdfs:subClassOf obo:HP_0012532, obo:SCDO_0001023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000234 obo:IAO_0000115 "Sickle cell pain management that aims to restore function and improve the quality of life." ; obo:SCDO_0000303 "Request inclusion into MESH below \"Pain Management\" / \"Sickle Cell Pain Management\" (also to be suggested for inclusion)" ; obo:SCDO_0000340 obo:SCDO_1000152 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Chronic Sickle Cell Pain Treatment" ; a owl:Class ; rdfs:label "Chronic Sickle Cell Pain Management" ; rdfs:subClassOf obo:SCDO_0001052, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000952 ] . obo:SCDO_0000235 obo:IAO_0000115 "An indication of a person's current cigarette use as well as some indication of cigarette smoking history." ; obo:SCDO_0000303 "Request inclusion below \"smoking status\" in Exposure Ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Cigarette Smoking Status Measurement" ; a owl:Class ; rdfs:label "Cigarette Smoking Status" ; rdfs:subClassOf obo:NCIT_C29719, obo:SCDO_1000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000320 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000321 ] . obo:SCDO_0000236 obo:IAO_0000115 "Meteorological conditions, including temperature, precipitation, and wind, that characteristically prevail in a particular region; includes regions of the earth having particular meteorological conditions." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/CRISP?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FCSP%2F1035-6799" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000236" ; oboInOwl:hasDbXref "CRISP:1035-6799" ; a owl:Class ; rdfs:label "Climate" ; rdfs:subClassOf obo:SCDO_0000897 . obo:SCDO_0000245 obo:IAO_0000115 "Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)" ; obo:SCDO_0000303 "Add specific Sickle Cell Disease related codes as instances/individuals below *Clinical Coding*? (see ICD-10 codes here: www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D059019" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000245" ; oboInOwl:hasDbXref "MESH:D059019" ; oboInOwl:hasExactSynonym "Coding", "Medical Coding" ; a owl:Class ; rdfs:label "Clinical Coding" ; rdfs:subClassOf obo:SCDO_0000738 . obo:SCDO_0000246 obo:IAO_0000115 "The capability to perform acceptably those duties directly related to patient care." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D002983" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000246" ; oboInOwl:hasDbXref "MESH:D002983" ; oboInOwl:hasExactSynonym "Clinical Competencies", "Clinical Competency", "Clinical Skill", "Competencies, Clinical", "Competency, Clinical", "Skill, Clinical", "Skills, Clinical" ; a owl:Class ; rdfs:label "Clinical Competence" ; rdfs:subClassOf obo:SCDO_0000948 . obo:SCDO_0000247 obo:IAO_0000115 "'Work that consists of a conference of physicians on their observations of a patient at the bedside, regarding the physical state, laboratory and other diagnostic findings, clinical manifestations, results of current therapy, etc. A clinical conference usually ends with a confirmation or correction of clinical findings by a pathological diagnosis performed by a pathologist. Clinical conference is often referred to as a clinico-pathological conference. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016429" ; oboInOwl:hasDbXref "MESH:D016429" ; oboInOwl:hasExactSynonym "Clinico-Pathologic Conference", "Clinico-Pathological Conference" ; a owl:Class ; rdfs:label "obsolete Clinical Conference" ; rdfs:subClassOf obo:SCDO_0000941 ; owl:deprecated true . obo:SCDO_0000249 obo:IAO_0000115 "'A quick and accurate way of assessing the patient health states using well defined set of questions and analyzed for an optimal clinical decision for the patient. [Curator team: Gaston K. Mazandu]'" ; a owl:Class ; rdfs:label "obsolete Clinical Diagnostic Questionnaire" ; rdfs:subClassOf obo:SCDO_0000957 ; owl:deprecated true . obo:SCDO_0000250 obo:IAO_0000115 "A physician administered examination to assess peripheral neuropathy." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Neuropathy - Clinical Assessment #130201" ; obo:SCDO_0000486 "Can be used to assess the severity of symptoms and disability associated with peripheral neuropathy caused by a number of disorders including tumors, infections, autoimmune diseases, and inherited disorders such as Charcot-Marie-Tooth disease." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000250" ; dc:source ; oboInOwl:hasDbXref "phenX:130201" ; oboInOwl:hasExactSynonym "Charcot-Marie-Tooth Neuropathy Score", "Neuropathy - Clinical Assessment" ; a owl:Class ; rdfs:label "Clinical Neuropathy Assessment" ; rdfs:subClassOf obo:SCDO_0000898 . obo:SCDO_0000251 obo:IAO_0000115 "Abnormal clinical manifestations of beta thalassemia that are as a result of the underlying genotype." ; obo:SCDO_0000303 "Could this not rather be \"Clinical Subtype of Beta Thalassemia\"? See \"clinical subtype\" in Orphanet.", "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "Clinical Phenotype of Beta Thalassemia" ; rdfs:subClassOf obo:SCDO_0000111, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:HP_0011904 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_1000707 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_0007624 ] . obo:SCDO_0000252 obo:IAO_0000115 "'A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000068397" ; oboInOwl:hasDbXref "MESH:D000068397" ; a owl:Class ; rdfs:label "obsolete Clinical Study" ; rdfs:subClassOf obo:SCDO_0000941 ; owl:deprecated true . obo:SCDO_0000253 obo:IAO_0000115 "Works about research studies that evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies." ; obo:SCDO_0000303 "Term to be adapted as necessary to match EDDA Study Designs Taxonomy" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000068456" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000253" ; oboInOwl:hasDbXref "MESH:D000068456" ; a owl:Class ; rdfs:label "Clinical Studies as Topic" ; rdfs:subClassOf obo:SCDO_0300004 . obo:SCDO_0000254 obo:IAO_0000115 "'A work that reports on the results of a clinical study in which participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Participants may receive diagnostic, therapeutic, or other types of interventions. While most clinical trials concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016430" ; oboInOwl:hasDbXref "MESH:D016430" ; oboInOwl:hasExactSynonym "Intervention Study" ; a owl:Class ; rdfs:label "obsolete Clinical Trial" ; rdfs:subClassOf obo:SCDO_0000252 ; owl:deprecated true . obo:SCDO_0000255 obo:IAO_0000115 "'Work that is the report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on a small number of healthy persons and conducted over the period of about a year in either the United States or a foreign country. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017426" ; oboInOwl:hasDbXref "MESH:D017426" ; oboInOwl:hasExactSynonym "Clinical Trial, Phase 1" ; a owl:Class ; rdfs:label "obsolete Clinical Trial, Phase I" ; rdfs:subClassOf obo:SCDO_0000254 ; owl:deprecated true . obo:SCDO_0000256 obo:IAO_0000115 "'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on several hundred volunteers, including a limited number of patients, and conducted over a period of about two years in either the United States or a foreign country. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017427" ; oboInOwl:hasDbXref "MESH:D017427" ; oboInOwl:hasExactSynonym "Clinical Trial, Phase 2" ; a owl:Class ; rdfs:label "obsolete Clinical Trial, Phase II" ; rdfs:subClassOf obo:SCDO_0000254 ; owl:deprecated true . obo:SCDO_0000257 obo:IAO_0000115 "'Work that is a report of a planned post-marketing study of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale after clinical trials, phases I, II, and III. These studies, conducted in the United States or a foreign country, often garner additional data about the safety and efficacy of a product. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017429" ; oboInOwl:hasDbXref "MESH:D017429" ; oboInOwl:hasExactSynonym "Clinical Trial, Phase 4" ; a owl:Class ; rdfs:label "obsolete Clinical Trial, Phase IV" ; rdfs:subClassOf obo:SCDO_0000254 ; owl:deprecated true . obo:SCDO_0000258 obo:IAO_0000115 "'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques after phase II trials. A large enough group of patients is studied and closely monitored by physicians for adverse response to long-term exposure, over a period of about three years in either the United States or a foreign country. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017428" ; oboInOwl:hasDbXref "MESH:D017428" ; oboInOwl:hasExactSynonym "Clinical Trial, Phase 3" ; a owl:Class ; rdfs:label "obsolete Clinical Trial, Phase III" ; rdfs:subClassOf obo:SCDO_0000254 ; owl:deprecated true . obo:SCDO_0000259 obo:IAO_0000115 "Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D002986" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000259" ; oboInOwl:hasDbXref "MESH:D002986" ; a owl:Class ; rdfs:label "Clinical Trials as Topic" ; rdfs:subClassOf obo:SCDO_0000253 . obo:SCDO_0000262 obo:IAO_0000115 "A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D015928" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000262" ; oboInOwl:hasDbXref "MESH:D015928" ; oboInOwl:hasExactSynonym "CBT", "Cognition Therapies", "Cognition Therapy", "Cognitive Behavioral Therapies", "Cognitive Behavioral Therapy", "Cognitive Behaviour Therapy", "Cognitive Psychotherapies", "Cognitive Psychotherapy", "Cognitive Therapies" ; a owl:Class ; rdfs:label "Cognitive Therapy" ; rdfs:subClassOf obo:SCDO_0001284, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000465 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SYMP_0019161 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:SCDO_0000263 obo:IAO_0000115 "Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D015331" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000263" ; oboInOwl:hasDbXref "MESH:D015331" ; oboInOwl:hasExactSynonym "Cohort Analyses" ; a owl:Class ; rdfs:label "Cohort Studies" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000265 obo:IAO_0000115 "A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem reticular formation." ; obo:SCDO_0000303 "The specific type of Blood Test (s) used to diagnose a coma should be specified. -- -- Named Individual removed (is diagnosed by): -- As in any neurologic condition, history and examination form the cornerstone of diagnosis when the patient is in a coma; however, history must be obtained from family, friends, or EMS. The Glasgow Coma Scale is a system of examining a comatose patient. It is helpful for evaluating the depth of the coma, tracking the patient's progress, and predicting (somewhat) the ultimate outcome of the coma. The Glasgow Coma Scale assigns a different number of points for exam results in three different categories: opening the eyes, verbal response (using words or voice to respond), and motor response (moving a part of the body). Fifteen is the largest possible number of total points, indicating the highest level of functioning. The highest level of functioning would be demonstrated by an individual who spontaneously opens his/her eyes, gives appropriate answers to questions about his/her situation, and can carry out a command (such as \"move your leg\" or \"nod your head\"). Three is the least possible number of total points and would be given to a patient for whom not even a painful stimulus is sufficient to provoke a response. In the middle are those patients who may be able to respond, but who require an intense or painful stimulus, and whose response may demonstrate some degree of brain malfunctioning (such as a person whose only response to pain in a limb is to bend that limb in toward the body). When performed as part of the admission examination, a Glasgow score of three to five points often suggests that the patient has likely suffered fatal brain damage, while eight or more points indicates that the patient's chances for recovery are good. Expansion of the pupils and respiratory pattern are also important. Metabolic causes of coma are diagnosed from blood work and urinalysis to evaluate blood chemistry, drug screen, and blood cell abnormalities that may indicate infection. Anatomic causes of coma are diagnosed from CT (computed tomography) or MRI (magnetic resonance imaging) scans." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003128" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000265" ; oboInOwl:hasDbXref "MESH:D003128" ; oboInOwl:hasExactSynonym "Comas" ; a owl:Class ; rdfs:label "Coma" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C16809 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000139 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0000267 obo:IAO_0000115 "A co-existing or additional disease with reference to an initial diagnosis or with reference to the index condition that is the subject of study." ; obo:SCDO_0000303 """Request inclusion into relevant ontology As per: \"Transition and Sickle Cell Disease\" by Michael R. DeBaun, Joseph Telfair -- Include here: -- Asthma -- Osteonecrosis of the Femoral Head -- Restrictive Lung Disease (currently Chronic Restrictive Lung Disease in SCDO) -- Retinopathy -- Cardiac Dysfunction -- Renal Dysfunction/Renal Failure -- -- ...and others""" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Additional Disease", "Co-Existing Disease", "Co-Morbid Condition", "Co-Morbid Disease" ; a owl:Class ; rdfs:label "Comorbid Disease" ; rdfs:subClassOf obo:DOID_4, obo:OGMS_0000023 . obo:SCDO_0000268 obo:IAO_0000115 "Comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003160" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000268" ; oboInOwl:hasDbXref "MESH:D003160" ; oboInOwl:hasExactSynonym "Comparative Studies" ; a owl:Class ; rdfs:label "Comparative Study" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000271 obo:IAO_0000115 "Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (physical therapy modalities; diet; acupuncture) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment. Year introduced: 2002(1986)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000529" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000271" ; oboInOwl:hasDbXref "MESH:D000529" ; oboInOwl:hasExactSynonym "Complementary Medicine" ; a owl:Class ; rdfs:label "Complementary Therapy" ; rdfs:subClassOf obo:SCDO_0001152 . obo:SCDO_0000272 obo:IAO_0000115 "'Compound heterozygosity in medical genetics is the condition of having two heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state. [Curator team: []]'" ; a owl:Class ; rdfs:label "obsolete Compound Heterozygous Hemoglobinopathy" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000276 obo:IAO_0000115 "Dark red, comma- or corkscrew-shaped vascular fragment that appears to be isolated from neighboring blood vessels in the conjunctiva. Normally benign, this lesion can serve as the first diagnostic sign of sickle cell retinopathy. The conjunctival comma sign results from transient vaso-occlusive processes in the microvasculature of bulbar conjunctiva. It is not seen in sickle trait, but is common in SCD." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "Ballas et al 2010 Am J Hematol" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Conjunctival Comma Sign" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C75583 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0000277 obo:IAO_0000115 "'A work that consists of summary statements representing the majority and current agreement of physicians, scientists, and other professionals meeting to reach a consensus on a selected subject. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016446" ; oboInOwl:hasDbXref "MESH:D016446" ; a owl:Class ; rdfs:label "obsolete Consensus Development Conference" ; rdfs:subClassOf obo:SCDO_0000941 ; owl:deprecated true . obo:SCDO_0000278 obo:IAO_0000115 "'Work consisting of summary statements, from a conference sponsored by NIH, representing the majority of current opinion of physicians, scientists, and other professionals on a selected subject. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016447" ; oboInOwl:hasDbXref "MESH:D016447" ; oboInOwl:hasExactSynonym "NIH Consensus Development Conference" ; a owl:Class ; rdfs:label "obsolete Consensus Development Conference, NIH" ; rdfs:subClassOf obo:SCDO_0000277 ; owl:deprecated true . obo:SCDO_0000280 obo:IAO_0000115 "A tool for collecting standardized information on enrollees' experiences with health plans and their services." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Quality of Care - Children #820102" ; obo:SCDO_0000481 "Proxy (Primary caregiver)" ; obo:SCDO_0000486 "Used to assess the patient-reported health care needs and quality of service from health care providers for individuals with chronic conditions such as sickle cell disease (SCD)." ; obo:SCDO_0001222 "Children and adolescents, ages 17 and younger" ; obo:SCDO_0001335 "yes" ; obo:SCDO_1000288 "None" ; dc:source ; oboInOwl:hasDbXref "PhenX:820102" ; a owl:Class ; rdfs:comment "This measure includes general questions about access to care and quality of care and additional questions about the services provided to children with chronic conditions. Items CC1-CC38 of the questionnaire are version 4.0 of the Children with Chronic Conditions Item Set." ; rdfs:label "Consumer Assessment of Healthcare Providers and Systems (CAHPS) Health Plan Survey 4.0 Child Medicaid Questionnaire" ; rdfs:subClassOf obo:SCDO_0000947, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000282 obo:IAO_0000115 "A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D065187" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000282" ; oboInOwl:hasDbXref "MESH:D065187" ; oboInOwl:hasExactSynonym "Controlled Before-After Studies" ; a owl:Class ; rdfs:label "Controlled Pre-Post Studies" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000283 obo:IAO_0000115 "'A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterized as a randomized controlled trial. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018848" ; oboInOwl:hasDbXref "MESH:D018848" ; a owl:Class ; rdfs:label "obsolete Controlled Clinical Trial" ; rdfs:subClassOf obo:SCDO_0000254 ; owl:deprecated true . obo:SCDO_0000284 obo:IAO_0000115 "Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as randomized controlled trials as topic." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018849" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000284" ; oboInOwl:hasDbXref "MESH:D018849" ; a owl:Class ; rdfs:label "Controlled Clinical Trials as Topic" ; rdfs:subClassOf obo:SCDO_0000259 . obo:SCDO_0000286 obo:IAO_0000115 "A state of harmony between internal needs and external demands and the processes used in achieving this condition." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000223" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000286" ; oboInOwl:hasDbXref "MESH:D000223" ; oboInOwl:hasExactSynonym "Adaptive Behavior", "Adaptive Behaviors", "Coping Behavior", "Coping Behaviors", "Coping Skills", "Psychologic Adaptation", "Psychological Adaptation" ; a owl:Class ; rdfs:label "Coping Skill" ; rdfs:subClassOf obo:SCDO_0000746 . obo:SCDO_0000287 obo:IAO_0000115 "The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Abrams M.R., Phillips G. and Keefe F.J. (1989). Sickle cell disease pain: Relation of coping strategies" ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Adults with SCD" ; obo:SCDO_0001033 "Demonstrated validity with SCD populations USA and UK; several publications." ; obo:SCDO_0001222 "Adults" ; obo:SCDO_1000288 "None" ; dc:source "Gil K.M., Abrams M.R., Phillips G. and Keefe F.J. (1989). Sickle cell disease pain: Relation of coping strategies to adjustment. Journal of Consulting and Clinical Psychology, 57, 725-731." ; oboInOwl:hasExactSynonym "CSQ-SCD", "Coping Strategies Questionnaire revised for Sickle Cell Disease" ; a owl:Class ; rdfs:label "Coping Strategies Questionnaire revised for Sickle Cell Disease (CSQ-SCD)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0000288 obo:IAO_0000115 "The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Gil K.M., Williams D.A., Thompson, R.J. and Kinney, T.R. (1991). Sickle cell disease in children and adolescents: The relation of child and parent pain coping strategies to adjustment. Journal of Pediatric Psychology, 16, 643-663." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Children with SCD" ; obo:SCDO_0001033 "Demonstrated validity with SCD populations USA and UK; several publications." ; obo:SCDO_0001222 "Children" ; obo:SCDO_1000288 "None" ; dc:source "Gil K.M., Williams D.A., Thompson, R.J. and Kinney, T.R. (1991). Sickle cell disease in children and adolescents: The relation of child and parent pain coping strategies to adjustment. Journal of Pediatric Psychology, 16, 643-663." ; oboInOwl:hasExactSynonym "CSQ-SCD Children" ; a owl:Class ; rdfs:label "Coping Strategies Questionnaire revised for Sickle Cell Disease Children (CSQ-SCD Children)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0000291 obo:IAO_0000115 "A causal adverse drug event that is induced by a corticosteroid." ; obo:SCDO_0000303 "Request inclusion into OAE below \"Causal Adverse Drug Event\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source , , ; a owl:Class ; rdfs:label "Corticosteroid-Induced Adverse Event" ; rdfs:subClassOf obo:SCDO_0000191, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000199 ; owl:someValuesFrom obo:CHEBI_50858 ] . obo:SCDO_0000292 obo:IAO_0000115 "A corticosteroid-induced adverse event that has the outcome of vaso-occlusion." ; obo:SCDO_0000303 "Request inclusion into OAE below \"Corticosteroid-Induced Adverse Event\" (also suggested by us for inclusion)." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Corticosteroid-Induced Vaso-Occlusive Adverse Event" ; rdfs:subClassOf obo:SCDO_0000291, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000199 ; owl:someValuesFrom obo:CHEBI_50858 ] . obo:SCDO_0000294 obo:IAO_0000115 "The personal cost of disease which may be economic, social, or psychological. The cost of illness may be reflected in absenteeism, productivity, response to treatment, peace of mind, or quality of life. It differs from health care costs, the societal cost of providing services related to the delivery of health care." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017281" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000294" ; oboInOwl:hasDbXref "MESH:D017281" ; oboInOwl:hasExactSynonym "Burden of Illness", "Cost of Disease", "Cost of Sickness", "Costs of Disease", "Disease Cost", "Disease Costs", "Economic Burden of Disease", "Sickness Cost" ; a owl:Class ; rdfs:label "Cost of Illness" ; rdfs:subClassOf obo:SCDO_0000496, obo:SCDO_0000746 . obo:SCDO_0000295 obo:IAO_0000115 "The extent to which a health intervention can be regarded as providing value for money, based on a cost-effectiveness analysis that compares the costs and health effects of the intervention. This informs decision-makers who have to determine where to allocate limited healthcare resources." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly into MESH, perhaps in an appropriate place below \"Quality of Health Care\"." ; obo:SCDO_0000340 "http://www.medicine.ox.ac.uk/bandolier/painres/download/whatis/Cost-effect.pdf" ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasExactSynonym "Health Care Economics", "Health Economics" ; a owl:Class ; rdfs:label "Cost-Effectiveness of Healthcare" ; rdfs:subClassOf obo:SCDO_0000495 . obo:SCDO_0000296 obo:IAO_0000115 "A bioassay to measure the serum concentration of creatinine, a metabolite of muscle creatine that is filtered out of blood by the kidneys." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000296" ; oboInOwl:hasDbXref "phenX:141400" ; oboInOwl:hasExactSynonym "Blood Creatinine Assay", "Blood Creatinine Test", "Serum Creatinine", "Serum Creatinine Assay" ; a owl:Class ; rdfs:label "Creatinine Blood Test" ; rdfs:subClassOf obo:SCDO_0000133, obo:SCDO_0000676, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000570 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000297 obo:IAO_0000115 "Brief therapeutic approach which is ameliorative rather than curative of acute psychiatric emergencies. Used in contexts such as emergency rooms of psychiatric or general hospitals, or in the home or place of crisis occurrence, this treatment approach focuses on interpersonal and intrapsychic factors and environmental modification. (APA Thesaurus of Psychological Index Terms, 7th ed)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003419" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000297" ; oboInOwl:hasDbXref "MESH:D003419" ; oboInOwl:hasExactSynonym "Crisis Interventions", "Interventions, Crisis" ; a owl:Class ; rdfs:label "Crisis Intervention" ; rdfs:subClassOf obo:SCDO_0000940 . obo:SCDO_0000298 obo:IAO_0000115 "Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with longitudinal studies which are followed over a period of time." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003430" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000298" ; oboInOwl:hasDbXref "MESH:D003430" ; oboInOwl:hasExactSynonym "Cross-Sectional Analysis", "Cross-Sectional Study" ; a owl:Class ; rdfs:label "Cross-Sectional Studies" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000299 obo:IAO_0000115 "A collective expression for all behaviour patterns acquired and socially transmitted through symbols. Culture includes customs, traditions, and language." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003469" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000299" ; oboInOwl:hasDbXref "MESH:D003469" ; oboInOwl:hasExactSynonym "Cultural Beliefs", "Cultural Values" ; a owl:Class ; rdfs:label "Culture" ; rdfs:subClassOf obo:NCIT_C17047 . obo:SCDO_0000301 obo:IAO_0000115 "Therapeutics relating to or used in the cure of diseases." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "http://www.merriam-webster.com/dictionary/curative" ; a owl:Class ; rdfs:label "Curative Therapeutics" ; rdfs:subClassOf obo:SCDO_0001152 . obo:SCDO_0000303 obo:IAO_0000115 "An administrative note of use for a curator but of no use for a user." ; obo:SCDO_0000340 obo:IAO_0000232 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "organizational term" ; oboInOwl:hasDbXref "IAO:0000232" ; oboInOwl:hasExactSynonym "editor_notes" ; a owl:AnnotationProperty ; rdfs:label "curator note" . obo:SCDO_0000304 obo:IAO_0000115 "The length of time that a person has lived since their birth up until the current day." ; obo:SCDO_1000288 "Few but available definitions not adequate" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Current Chronological Age" ; a owl:Class ; rdfs:label "Current Age" ; rdfs:subClassOf obo:NCIT_C25150 . obo:SCDO_0000305 obo:IAO_0000115 "The respondent's highest level of education at the current time." ; obo:SCDO_0000303 "Request inclusion into MESH below \"Socioeconomic Factors\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Educational Attainment" ; a owl:Class ; rdfs:label "Current Educational Attainment" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0000414, obo:SCDO_0001090, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000306 obo:IAO_0000115 "The respondent's current employment status." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Current Employment Status #11301" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000306" ; oboInOwl:hasDbXref "phenX:11301" ; oboInOwl:hasExactSynonym "Employment Status" ; a owl:Class ; rdfs:label "Current Employment Status" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0001090, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000307 obo:IAO_0000115 "The respondent's current marital status." ; obo:SCDO_0000303 "Can add sub-classes of \"Marital Status\" from MESH." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Current Marital Status #10902" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000307" ; oboInOwl:hasDbXref "phenX:10902" ; oboInOwl:hasExactSynonym "Marital Status", "Marital or Partnership Status" ; a owl:Class ; rdfs:label "Current Marital Status" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0001090, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000310 obo:IAO_0000115 "The amount of the protein cystatin C (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide) found in a specified sample of blood. This extracellular cystatin subtype is abundantly expressed in bodily fluids." ; obo:SCDO_0000303 "This class is used as a biomarker of kidney function and kidney disease." ; obo:SCDO_0000340 obo:CMO_0002777, "http://purl.bioontology.org/ontology/MESH/D055316", "http://www.ebi.ac.uk/efo/EFO_0004617" ; obo:SCDO_1000288 "Suggest update to description in CMO" ; dc:source ; oboInOwl:hasDbXref "CMO:0002777" ; oboInOwl:hasExactSynonym "Blood CC Level", "Cystatin 3 Level", "Gamma Trace Level", "Gamma-Trace Level", "Neuroendocrine Basic Polypeptide Level", "Post Gamma Globulin Level", "Post-Gamma-Globulin Level" ; oboInOwl:hasRelatedSynonym "Blood Cst3 Level" ; a owl:Class ; rdfs:label "Blood Cystatin C Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000310 ] . obo:SCDO_0000311 obo:IAO_0000115 "A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia." ; obo:SCDO_0000340 "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000311" ; oboInOwl:hasDbXref "ICD10CM:D57" ; oboInOwl:hasExactSynonym "D57" ; a owl:Class ; rdfs:label "D57 Sickle-Cell Disorders" ; rdfs:subClassOf obo:SCDO_0000607 . obo:SCDO_0000312 obo:IAO_0000115 "Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis." ; obo:SCDO_0000340 "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.0" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000312" ; oboInOwl:hasDbXref "ICD10CM:D57.0" ; oboInOwl:hasExactSynonym "D57.0", "Hb-SS disease with vasoocclusive pain", "Sickle cell anemia with crisis", "Sickle cell anemia with vasoocclusive pain" ; a owl:Class ; rdfs:label "D57.0 Hb-SS disease with crisis" ; rdfs:subClassOf obo:SCDO_0000311, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000313 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.01" ; oboInOwl:hasDbXref "ICD10CM:D57.01" ; oboInOwl:hasExactSynonym "D57.01", "Hb-SS disease with acute chest syndrome", "Sickle cell anemia with acute chest syndrome", "Sickle cell anemia, acute chest syndrome" ; a owl:Class ; rdfs:label "D57.01 Hb-SS disease with acute chest syndrome" ; rdfs:subClassOf obo:SCDO_0000312, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000314 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.02" ; oboInOwl:hasDbXref "ICD10CM:D57.02" ; oboInOwl:hasExactSynonym "Acute sickle cell splenic sequestration crisis", "D57.02", "Hb-SS disease with splenic sequestration", "Sickle cell anemia acute crisis splenic sequestration" ; a owl:Class ; rdfs:label "D57.02 Hb-SS disease with splenic sequestration" ; rdfs:subClassOf obo:SCDO_0000312, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0007161 ] . obo:SCDO_0000315 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.1" ; oboInOwl:hasDbXref "ICD10CM:D57.1" ; oboInOwl:hasExactSynonym "D57.1", "Sickle cell anemia without crisis", "Sickle-cell disease without crisis" ; a owl:Class ; rdfs:label "D57.1 Sickle-cell disease without crisis" ; rdfs:subClassOf obo:SCDO_0000311, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C131682 ] . obo:SCDO_0000316 obo:IAO_0000115 "One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c. It is similar to, but less severe than sickle cell anemia." ; obo:SCDO_0000340 "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.2" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000316" ; oboInOwl:hasDbXref "ICD10CM:D57.2" ; oboInOwl:hasExactSynonym "D57.2" ; a owl:Class ; rdfs:label "D57.2 Sickle-cell/Hb-C disease" ; rdfs:subClassOf obo:SCDO_0000311, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ] . obo:SCDO_0000317 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.20" ; oboInOwl:hasDbXref "ICD10CM:D57.20" ; oboInOwl:hasExactSynonym "D57.20", "Sickle Cell Disease-SC without crisis", "Sickle-cell/Hb-C disease without crisis" ; a owl:Class ; rdfs:label "D57.20 Sickle-cell/Hb-C disease without crisis" ; rdfs:subClassOf obo:SCDO_0000316, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C3833 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ] . obo:SCDO_0000318 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.21" ; oboInOwl:hasDbXref "ICD10CM:D57.21" ; oboInOwl:hasExactSynonym "D57.21", "Sickle Cell Disease-SC with crisis", "Sickle-cell/Hb-C disease with crisis" ; a owl:Class ; rdfs:label "D57.21 Sickle-cell/Hb-C disease with crisis" ; rdfs:subClassOf obo:SCDO_0000316, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ] . obo:SCDO_0000319 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.211" ; oboInOwl:hasDbXref "ICD10CM:D57.211" ; oboInOwl:hasExactSynonym "Acute chest syndrome due to sickle cell-hemoglobin c disease crisis", "Acute chest syndrome sickle cell hb-c crisis", "D57.211", "Sickle Cell Disease-SC with acute chest syndrome", "Sickle-cell/Hb-C disease with acute chest syndrome" ; a owl:Class ; rdfs:label "D57.211 Sickle-cell/Hb-C disease with acute chest syndrome" ; rdfs:subClassOf obo:SCDO_0000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ] . obo:SCDO_0000320 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.212" ; oboInOwl:hasDbXref "ICD10CM:D57.212" ; oboInOwl:hasExactSynonym "D57.212", "Sickle Cell Disease-SC with splenic sequestration", "Sickle-cell/Hb-C disease with splenic sequestration" ; a owl:Class ; rdfs:label "D57.212 Sickle-cell/Hb-C disease with splenic sequestration" ; rdfs:subClassOf obo:SCDO_0000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0007161 ] . obo:SCDO_0000321 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.219" ; oboInOwl:hasDbXref "ICD10CM:D57.219" ; oboInOwl:hasExactSynonym "D57.219", "Sickle Cell Disease-SC with crisis NOS", "Sickle Cell Disease-SC with crisis, unspecified", "Sickle Cell Disease-SC with vasoocclusive pain NOS", "Sickle cell-hemoglobin c disease with crisis", "Sickle-cell/Hb-C disease with crisis NOS", "Sickle-cell/Hb-C disease with crisis, unspecified", "Sickle-cell/Hb-C disease with vasoocclusive pain NOS" ; a owl:Class ; rdfs:label "D57.219 Sickle-cell/Hb-C disease with crisis, unspecified" ; rdfs:subClassOf obo:SCDO_0000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ] . obo:SCDO_0000322 obo:IAO_0000115 "The condition of being heterozygous for hemoglobin S." ; obo:SCDO_0000340 "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.3" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000322" ; oboInOwl:hasDbXref "ICD10CM:D57.3" ; oboInOwl:hasExactSynonym "D57.3" ; a owl:Class ; rdfs:label "D57.3 Sickle-cell trait" ; rdfs:subClassOf obo:SCDO_0000311, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001055 ] . obo:SCDO_0000323 obo:IAO_0000115 "Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene." ; obo:SCDO_0000340 "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.4" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000323" ; oboInOwl:hasDbXref "ICD10CM:D57.4" ; oboInOwl:hasExactSynonym "D57.4" ; a owl:Class ; rdfs:label "D57.4 Sickle-cell thalassemia" ; rdfs:subClassOf obo:SCDO_0000311, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0007656 ] . obo:SCDO_0000324 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.40" ; oboInOwl:hasDbXref "ICD10CM:D57.40" ; oboInOwl:hasExactSynonym "D57.40" ; a owl:Class ; rdfs:label "D57.40 Sickle-cell thalassemia without crisis" ; rdfs:subClassOf obo:SCDO_0000323, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C3833 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C95539 ] . obo:SCDO_0000325 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.41" ; oboInOwl:hasDbXref "ICD10CM:D57.41" ; oboInOwl:hasExactSynonym "D57.41", "Sickle-cell thalassemia with (painful) crisis", "Sickle-cell thalassemia with crisis", "Sickle-cell thalassemia with vasoocclusive pain" ; a owl:Class ; rdfs:label "D57.41 Sickle-cell thalassemia, unspecified, with crisis" ; rdfs:subClassOf obo:SCDO_0000323, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000326 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.411" ; oboInOwl:hasDbXref "ICD10CM:D57.411" ; oboInOwl:hasExactSynonym "D57.411", "Sickle-cell thalassemia, unspecified, with acute chest syndrome" ; a owl:Class ; rdfs:label "D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome" ; rdfs:subClassOf obo:SCDO_0000325, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000327 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.412" ; oboInOwl:hasDbXref "ICD10CM:D57.412" ; oboInOwl:hasExactSynonym "D57.412", "Sickle cell thalassemia with splenic sequestration", "Sickle-cell thalassemia, unspecified, with splenic sequestration" ; a owl:Class ; rdfs:label "D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration" ; rdfs:subClassOf obo:SCDO_0000325, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0007161 ] . obo:SCDO_0000328 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.419" ; oboInOwl:hasDbXref "ICD10CM:D57.419" ; oboInOwl:hasExactSynonym "D57.419", "Sickle-cell thalassemia with (painful) crisis NOS", "Sickle-cell thalassemia with vasoocclusive pain NOS", "Sickle-cell thalassemia, unspecified, with crisis" ; a owl:Class ; rdfs:label "D57.419 Sickle-cell thalassemia, unspecified, with crisis" ; rdfs:subClassOf obo:SCDO_0000325, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000329 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.8" ; oboInOwl:hasDbXref "ICD10CM:D57.8" ; oboInOwl:hasExactSynonym "D57.8", "Other sickle-cell disorders" ; a owl:Class ; rdfs:label "D57.8 Other sickle-cell disorders" ; rdfs:subClassOf obo:SCDO_0000311 . obo:SCDO_0000330 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.80" ; oboInOwl:hasDbXref "ICD10CM:D57.80" ; oboInOwl:hasExactSynonym "D57.80" ; a owl:Class ; rdfs:label "D57.80 Other sickle-cell disorders without crisis" ; rdfs:subClassOf obo:SCDO_0000329, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C3833 ] . obo:SCDO_0000331 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.81" ; oboInOwl:hasDbXref "ICD10CM:D57.81" ; oboInOwl:hasExactSynonym "D57.81" ; a owl:Class ; rdfs:label "D57.81 Other sickle-cell disorders with crisis" ; rdfs:subClassOf obo:SCDO_0000329, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000332 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.811" ; oboInOwl:hasDbXref "ICD10CM:D57.811" ; oboInOwl:hasExactSynonym "D57.811" ; a owl:Class ; rdfs:label "D57.811 Other sickle-cell disorders with acute chest syndrome" ; rdfs:subClassOf obo:SCDO_0000331, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000333 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.812" ; oboInOwl:hasDbXref "ICD10CM:D57.812" ; oboInOwl:hasExactSynonym "D57.812" ; a owl:Class ; rdfs:label "D57.812 Other sickle-cell disorders with splenic sequestration" ; rdfs:subClassOf obo:SCDO_0000331, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0007161 ] . obo:SCDO_0000334 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.819" ; oboInOwl:hasDbXref "ICD10CM:D57.819" ; oboInOwl:hasExactSynonym "D57.819" ; a owl:Class ; rdfs:label "D57.819 Other sickle-cell disorders with crisis, unspecified" ; rdfs:subClassOf obo:SCDO_0000331, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0000338 obo:IAO_0000115 "'Protein molecule are large, complex molecules that play many critical roles in the body. They do most of the work in cells and are required for the structure, function, and regulation of the body's tissues and organs. [Curator team: []]'" ; obo:SCDO_0000340 "https://ghr.nlm.nih.gov/primer/howgeneswork/protein" ; a owl:Class ; rdfs:label "obsolete Protein Molecule" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000340 obo:IAO_0000115 "A source from where the formal description was derived. This can be in the form of a link to a relevant webpage, the IRI of a term in an existing ontology, a reference to specific literature, etc." ; obo:SCDO_0000340 obo:IAO_0000119 ; obo:SCDO_0000363 "yes" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; oboInOwl:hasDbXref "IAO:0000119" ; a owl:AnnotationProperty ; rdfs:label "definition source" ; skos:prefLabel "description source" . obo:SCDO_0000343 obo:IAO_0000115 "A form of beta-thalassemia characterized by decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000343" ; oboInOwl:hasDbXref "ORPHA:231237" ; oboInOwl:hasExactSynonym "Delta Beta Thalassaemia", "Delta-Beta-Thalassaemia", "Delta-Beta-Thalassemia", "F Thalassaemia" ; a owl:Class ; rdfs:label "Delta Beta Thalassemia" ; rdfs:subClassOf obo:SCDO_0000111, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_0005671 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0005671 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000976 ] . obo:SCDO_0000344 obo:IAO_0000115 "A hereditary disorder characterized by reduced or absent delta-globin thus effecting the level of hemoglobin A2, a minor component of adult hemoglobin monitored in the diagnosis of beta-thalassemia." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D055538" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000344" ; oboInOwl:hasDbXref "MESH:D055538" ; oboInOwl:hasExactSynonym "Delta Thalassaemia", "Delta Thalassaemias", "Delta Thalassemias", "Delta-Thalassaemia", "Delta-Thalassaemias", "Delta-Thalassemia" ; a owl:Class ; rdfs:label "Delta Thalassemia" ; rdfs:subClassOf obo:NCIT_C35069 . obo:SCDO_0000346 obo:IAO_0000115 "An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with Dengue Virus. It is self-limiting and characterized by fever, myalgia, headache, and rash. Severe Dengue is a more virulent form of dengue." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003715" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000346" ; oboInOwl:hasDbXref "MESH:D003715" ; oboInOwl:hasExactSynonym "Break Bone Fever", "Break-Bone fever", "Breakbone Fever", "Dengue" ; a owl:Class ; rdfs:label "Dengue Fever" ; rdfs:subClassOf obo:NCIT_C3439, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0000347 obo:IAO_0000115 "'The system pertaining to teeth, oral cavity, and associated structures. [Curator team: []]'" ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/dentistry" ; a owl:Class ; rdfs:label "deprecated Dental System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000359 obo:IAO_0000115 "Terms that are no longer being used in the ontology." ; a owl:Class ; rdfs:label "deprecated terms" ; rdfs:subClassOf owl:Thing . obo:SCDO_0000360 obo:IAO_0000115 "A common mental disorder, characterized by sadness, hopelessness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration. Depression can be long-lasting or recurrent, substantially impairing an individual's ability to function at work or school or cope with daily life." ; obo:SCDO_0000340 "http://www.who.int/topics/depression/en/" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000360" ; oboInOwl:hasDbXref "SIO:000824" ; oboInOwl:hasExactSynonym "Depressive Symptoms", "Low Mood" ; a owl:Class ; rdfs:label "Depression" ; rdfs:subClassOf obo:HP_0000708, obo:SCDO_0000746, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000940 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000363 obo:IAO_0000115 "An assertion of whether or not the term/class description is an adaptation of the description in the description source." ; obo:SCDO_0000303 "Requested inclusion of this property into RO. Check details here again after inclusion." ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:comment """'yes' indicates that only the description has been adaptation from the source. 'no' indicates that neither the label nor the description have been adapted from the source. 'only label adapted' indicates that only the label has been adapted from the source but the description is the same as that provided by the source. 'label and description adapted' indicates that both the label and the description have been adapted from the source.""", "This property is required unless dc:creator is \"SCDO\"." ; rdfs:label "description adapted from source" ; rdfs:range , . obo:SCDO_0000365 obo:IAO_0000115 "Skill in performing tasks, especially with the hands." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://en.oxforddictionaries.com/definition/dexterity" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Dexterity" ; rdfs:subClassOf obo:SCDO_0000900 . obo:SCDO_0000376 obo:IAO_0000115 "A medical device used to diagnose medical conditions." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0001448" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000376" ; oboInOwl:hasDbXref "ERO:0001448" ; a owl:Class ; rdfs:label "Diagnostic Device" ; rdfs:subClassOf obo:SCDO_0000379 . obo:SCDO_0000379 obo:IAO_0000115 "Diagnostic tools (including the instruments, laboratory assays and methods of patient examination) used for differential diagnosis, the measurements obtained using these tools, and the diagnostic devices used in obtaining the measurements." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Diagnostics" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_0000380 obo:IAO_0000115 "A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000380" ; oboInOwl:hasDbXref "MESH:D004008" ; oboInOwl:hasExactSynonym "2-((2,6-dichlorophenyl)amino)benzeneacetic acid", "Diclofenac Acid", "Orthofen", "[2-(2,6-dichloroanilino)phenyl]acetic acid" ; a owl:Class ; rdfs:label "Diclofenac" ; rdfs:subClassOf obo:CHEBI_35475, obo:CHEBI_35493, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0000382 obo:IAO_0000115 "Concepts involved with nutritional physiology, including categories of substances eaten for sustenance, nutritional phenomena and processes, eating patterns and habits, and measurable nutritional parameters." ; obo:SCDO_0000303 "Should this term rather be replaced by more specific terms such as Dietary Intake? Or have such terms as sub-classes?" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000066888" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000382" ; oboInOwl:hasDbXref "MESH:D000066888" ; a owl:Class ; rdfs:label "Diet, Food, and Nutrition" ; rdfs:subClassOf obo:SCDO_0000487, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000938 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001298 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002076 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0009830 ] . obo:SCDO_0000383 a owl:Class ; rdfs:label "obsolete Diffusion Capacity by Biochemical Methods" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000384 obo:IAO_0000115 "The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the blood-air barrier." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011653" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000384" ; oboInOwl:hasDbXref "MESH:D011653" ; oboInOwl:hasExactSynonym "Alveolar membrane diffusion capacity", "DL", "Diffusing Capacity", "Membrane diffusion capacity", "Pulmonary Diffusing Capacity" ; a owl:Class ; rdfs:label "Diffusion Capacity of Lung" ; rdfs:subClassOf obo:CMO_0000094, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000385 ] . obo:SCDO_0000385 obo:IAO_0000115 "Clinical assessment to determine the capacity of an individual's lung to exchange gases (e.g., oxygen and carbon dioxide) across the alveolar-capillary interface." ; obo:SCDO_0000303 """Suggest update to label in PhenX (from \"Lung Function - Diffusion Capacity\") Need to add equipment used for this test under \"Devices\" and link to them below.""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Lung Function - Diffusion Capacity #810301" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:810301" ; oboInOwl:hasExactSynonym "Pulmonary Diffusing Capacity Test" ; a owl:Class ; rdfs:label "Diffusion Capacity Test" ; rdfs:subClassOf obo:SCDO_0000942, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000384 ] . obo:SCDO_0000386 obo:IAO_0000115 "One DALY can be thought of as one lost year of \"healthy\" life. The sum of these DALYs across the population, or the burden of disease, can be thought of as a measurement of the gap between current health status and an ideal health situation where the entire population lives to an advanced age, free of disease and disability." ; obo:SCDO_0000340 ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self; Proxy" ; obo:SCDO_0000482 "All" ; obo:SCDO_0001033 "WHO Global Burden of Disease assessment, also used in SCD studies" ; obo:SCDO_0001222 "Children and adults" ; obo:SCDO_0001335 "no" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasExactSynonym "DALY", "Disability-Adjusted Life Year" ; a owl:Class ; rdfs:comment "Calculation: DALY = YLL + YLD - The YLL basically correspond to the number of deaths multiplied by the standard life expectancy at the age at which death occurs. The basic formula for YLL (without yet including other social preferences discussed below), is the following for a given cause, age and sex: YLL = N x L where: N = number of deaths L = standard life expectancy at age of death in years. Because YLL measure the incident stream of lost years of life due to deaths, an incidence perspective has also been taken for the calculation of YLD in the original Global Burden of Disease Study for year 1990 and in subsequent WHO updates for years 2000 to 2004. To estimate YLD for a particular cause in a particular time period, the number of incident cases in that period is multiplied by the average duration of the disease and a weight factor that reflects the severity of the disease on a scale from 0 (perfect health) to 1 (dead). The basic formula for YLD is the following (again, without applying social preferences): YLD = I x DW x L where: I = number of incident cases; DW = disability weight; L = average duration of the case until remission or death (years). Prevalence YLD - The recent GBD 2010 study published by IHME in December 2012 used an updated life expectancy standard for the calculation of YLL and based the YLD calculation on prevalence rather than incidence: YLD = P x DW where: P = number of prevalent cases; DW = disability weight." ; rdfs:label "Disability-Adjusted Life Year (DALY)" ; rdfs:subClassOf obo:SCDO_0000495, obo:SCDO_0000951 . obo:SCDO_0000388 obo:IAO_0000115 "Sudden calamitous events producing great material damage, loss, and distress. They are the result of natural phenomena such as earthquakes, floods, etc. Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D004190" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000388" ; oboInOwl:hasDbXref "MESH:D004190" ; oboInOwl:hasExactSynonym "Disasters", "Natural Disaster", "Natural Disasters" ; a owl:Class ; rdfs:label "Disaster" ; rdfs:subClassOf obo:SCDO_0000897 . obo:SCDO_0000391 obo:IAO_0000115 "A factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease." ; obo:SCDO_0000303 "Request inclusion into relevant ontology", "These article contains a recent description of disease modifiers for SCD: http://www.nejm.org/doi/10.1056/NEJMra1510865 -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562292/ -- -- Paper mentioning haplotypes and severity: -- https://www.nature.com/scitable/topicpage/sickle-cell-anemia-a-look-at-global-8756219 -- -- Initially, the HP term \"Clinical Modifier\" (HP:0012823) was used to define this class, but its usage was found to be more \"ontology-based\" than what the SCDO intended." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Phenotypic Modifier" ; a owl:Class ; rdfs:label "Disease Modifier" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_0000396 obo:IAO_0000115 "A diagnostic ultrasound-based imaging technique operating at the frequency range of 2 megahertz. This machine makes use of the doppler effect to measure and visualise blood flow for possible pathology or lesions within blood vessels." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "Doppler Ultrasound Machine - 2 Megahertz" ; rdfs:subClassOf obo:OBI_0001098, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0001114 ] . obo:SCDO_0000397 obo:IAO_0000115 "An adverse event that has an outcome of a decreased amount of the drug excreted by the body." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000887" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000397" ; oboInOwl:hasDbXref "OAE:0000887" ; a owl:Class ; rdfs:label "Drug Clearance Decreased AE" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000398 obo:IAO_0000115 "An adverse drug event that results in the development of a dependence on the drug." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000888" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000398" ; oboInOwl:hasDbXref "OAE:0000888" ; a owl:Class ; rdfs:label "Drug Dependence AE" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000399 obo:IAO_0000115 "The amount of drug substances taken into the body." ; obo:SCDO_0000303 "This seemed an obvious addition to the modifier class?" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Drug Intake" ; rdfs:subClassOf obo:SCDO_0000487 . obo:SCDO_0000400 obo:IAO_0000115 "A drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000891" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000400" ; oboInOwl:hasDbXref "OAE:0000891" ; a owl:Class ; rdfs:label "Drug Intolerance AE" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000401 obo:IAO_0000115 "An adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000893" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000401" ; oboInOwl:hasDbXref "OAE:0000893" ; a owl:Class ; rdfs:label "Drug Withdrawal Syndrome AE" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000402 obo:IAO_0000115 "A neuropathy AE that is induced by a drug administration." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0000165" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000402" ; oboInOwl:hasDbXref "OAE:0000165" ; a owl:Class ; rdfs:label "Drug-Induced Neuropathy AE" ; rdfs:subClassOf obo:SCDO_0000191, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000199 ; owl:someValuesFrom obo:CHEBI_23888 ] . obo:SCDO_0000405 obo:IAO_0000115 "'The combined specialties of diseases of the ear, pharynx, and larynx, including the upper respiratory tract and diseases of the head and neck, tracheobronchial tree, and esophagus. [Curator team: []]'" ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/ear+nose+and+throat" ; oboInOwl:hasExactSynonym "Otolaryngology" ; a owl:Class ; rdfs:label "deprecated Ear, Nose and Throat" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000407 obo:IAO_0000115 "A small hemorrhagic spot, larger than a petechia, in the skin or mucous membrane forming a nonelevated, rounded or irregular, blue or purplish patch." ; obo:SCDO_0000303 "Suggest update to description. The term in the HPO was not detailed enough." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0031364" ; oboInOwl:hasExactSynonym "Ecchymoses" ; a owl:Class ; rdfs:label "Ecchymosis" ; rdfs:subClassOf obo:HP_0002597 . obo:SCDO_0000409 obo:IAO_0000115 "A physiological assay that uses standard ultrasound techniques to take two-dimensional pictures of the cardiovascular system and can produce accurate assessment of the velocity of blood and cardiac tissue at any arbitrary point using pulsed or continuous wave Doppler ultrasound." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0000385" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000409" ; oboInOwl:hasDbXref "ERO:0000385" ; oboInOwl:hasExactSynonym "Cardiac ECHO", "Cardiac US Scan", "Diagnostic Ultrasound of Heart", "Echocardiographic procedure", "Echocardiography", "US Scan of Heart", "Ultrasonic cardiography", "Ultrasonography of Heart", "Ultrasound of Heart" ; a owl:Class ; rdfs:label "Echocardiogram" ; rdfs:subClassOf obo:NCIT_C17230, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000410 obo:IAO_0000115 "A machine used for ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D004452" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Echocardiography Machine" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000474 ; owl:someValuesFrom obo:SCDO_0000502 ] . obo:SCDO_0000414 obo:IAO_0000115 "Acquisition of knowledge as a result of instruction in a formal course of study." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D004493" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000414" ; oboInOwl:hasDbXref "MESH:D004493" ; oboInOwl:hasExactSynonym "Schooling" ; a owl:Class ; rdfs:label "Education" ; rdfs:subClassOf obo:NCIT_C17047 . obo:SCDO_0000415 obo:IAO_0000115 "The visual output that an electrocardiograph produces." ; obo:SCDO_0000303 "Suggest update to description in ERO?" ; obo:SCDO_0000340 "http://en.wiktionary.org/wiki/electrocardiogram" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "ERO:0000383" ; oboInOwl:hasExactSynonym "ECG", "EKG" ; a owl:Class ; rdfs:label "Electrocardiogram" ; rdfs:subClassOf obo:SCDO_1000313 . obo:SCDO_0000416 obo:IAO_0000115 "Device which makes prolonged electrocardiographic recordings on a portable tape recorder (Holter-type system) or solid-state device (real-time system), while the patient undergoes normal daily activities; useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/CRISP/?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FCSP%2F1393-7164" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000416" ; oboInOwl:hasDbXref "CRISP:1393-7164" ; oboInOwl:hasExactSynonym "Ambulatory Electrocardiographic Monitor", "Electrocardiocorder" ; a owl:Class ; rdfs:label "Electrocardiographic Monitor" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:NCIT_C123446 ] . obo:SCDO_0000417 obo:IAO_0000115 "Recording of the moment-to-moment electromotive forces of the heart as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a cathode ray tube display." ; obo:SCDO_0000303 "Request that MESH removes ECG, EKG and Elecrocardiogram as synonyms." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000417" ; oboInOwl:hasDbXref "MESH:D004562" ; a owl:Class ; rdfs:label "Electrocardiography" ; rdfs:subClassOf obo:SCDO_0000500, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0000183 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0001295 ] . obo:SCDO_0000418 obo:IAO_0000115 "A graphic record of the electrical activity of the brain as recorded by an electroencephalograph." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/electroencephalogram" ; obo:SCDO_1000288 "Few but definitions not freely available" ; a owl:Class ; rdfs:label "Electroencephalogram" ; rdfs:subClassOf obo:SCDO_1000313 . obo:SCDO_0000419 obo:IAO_0000115 "An instrument that measures electrical potentials on the scalp and generates a record of the electrical activity of the brain." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/electroencephalograph" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Encephalograph" ; a owl:Class ; rdfs:label "Electroencephalograph" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000420 ] . obo:SCDO_0000420 obo:IAO_0000115 "Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D004569" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000420" ; oboInOwl:hasDbXref "MESH:D004569" ; oboInOwl:hasExactSynonym "EEG" ; a owl:Class ; rdfs:label "Electroencephalography" ; rdfs:subClassOf obo:SCDO_0000208, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0000419 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000161 ] . obo:SCDO_0000423 obo:IAO_0000115 "Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D057286" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000423" ; oboInOwl:hasDbXref "MESH:D057286" ; oboInOwl:hasExactSynonym "Computerized Health Records", "Computerized Medical Records", "Electronic Health Record", "Electronic Medical Record", "Electronic Medical Records" ; a owl:Class ; rdfs:label "Electronic Health Records" ; rdfs:subClassOf obo:SCDO_0000492 . obo:SCDO_0000424 obo:IAO_0000115 "An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current." ; obo:SCDO_0000303 "Perhaps change label to \"Hemoglobin Electrophoresis\"? Exactsynonym \"Hb ELP\". See dc:source provided." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D004586" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000424" ; dc:source ; oboInOwl:hasDbXref "MESH:D004586" ; a owl:Class ; rdfs:label "Electrophoresis" ; rdfs:subClassOf obo:SCDO_0000216 . obo:SCDO_0000431 obo:IAO_0000115 "The system pertaining to the stomach, intestines, and associated organs including liver, gallbladder, and pancreas." ; obo:IAO_0100001 obo:SCDO_0002674, obo:SCDO_0002780 ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/gastroenterology" ; oboInOwl:hasExactSynonym "Gastroenterology" ; a owl:Class ; rdfs:label "deprecated Endocrine and Metabolic" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000435 obo:IAO_0000115 "An environmental factor that modifies one or more aspects of sickle cell disease (SCD) (such as temporal pattern, age of onset and mortality) for specific phenotype(s) in the Phenotype class." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Perhaps include MESH term \"Life Change Events\" as a main sub-class, with \"Disaster\" (under Physical Environment) copied below it?""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Environmental Disease Modifier" ; rdfs:subClassOf obo:SCDO_0000391 . obo:SCDO_0000436 obo:IAO_0000115 "A method used to measure the relative activity of a specific enzyme or its concentration in solution. Typically an enzyme substrate is added to a buffer solution containing enzyme and the rate of conversion of substrate to product is measured under controlled conditions. Many classical enzymatic assay methods involve the use of synthetic colorimetric substrates and measuring the reaction rates using a spectrophotometer." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D057075" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000436" ; oboInOwl:hasDbXref "MESH:D057075" ; oboInOwl:hasExactSynonym "Enzyme Assay" ; a owl:Class ; rdfs:label "Enzymatic Assay" ; rdfs:subClassOf obo:SCDO_0000120 . obo:SCDO_0000437 obo:IAO_0000115 "Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are case-control studies; cohort studies; and cross-sectional studies." ; obo:SCDO_0000303 "Term to be adapted as necessary to match EDDA Study Designs Taxonomy" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016021" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000437" ; oboInOwl:hasDbXref "MESH:D016021" ; oboInOwl:hasExactSynonym "Epidemiological Studies" ; a owl:Class ; rdfs:label "Epidemiologic Studies" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_0000438 obo:IAO_0000115 "Types and formulations of studies used in epidemiological and clinical research." ; obo:SCDO_0000303 "Term to be adapted as necessary to match EDDA Study Designs Taxonomy" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016020" ; oboInOwl:hasDbXref "MESH:D016020" ; oboInOwl:hasExactSynonym "Epidemiologic Study Characteristics" ; a owl:Class ; rdfs:label "deprecated Epidemiologic Study Characteristics as Topic" ; rdfs:subClassOf obo:SCDO_0000990 ; owl:deprecated true . obo:SCDO_0000440 obo:IAO_0000115 "A questionnaire to assess epilepsy, a condition characterized by recurrent seizures and which is a component of over 40 neurological disorders (Aminoff, et al., 2005)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000440" ; oboInOwl:hasDbXref "phenX:130401" ; a owl:Class ; rdfs:label "Epilepsy Screener" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033 . obo:SCDO_0000441 obo:IAO_0000115 "The GHQ is a screening device for identifying minor psychiatric disorders in the general population and within community or non-psychiatric clinical settings such as primary care or general medical outpatients. Suitable for all ages from adolescent upwards (not children), it assesses the respondent's current state and asks if that differs from his or her usual state. It is therefore sensitive to short-term psychiatric disorders but not to long-standing attributes of the respondent. The self-administered questionnaire focuses on two major areas: inability to carry out normal functions; appearance of new and distressing phenomena. It is available in the following versions: GHQ-60 -- the fully detailed 60-item questionnaire; GHQ-30 -- a short form without items relating to physical illness; GHQ-28 -- a 28 item scaled version -- assesses somatic symptoms, anxiety and insomnia, social dysfunction and severe depression; GHQ-12 -- quick, reliable and sensitive short form, ideal for research studies." ; obo:SCDO_0000303 "Add the different versions of this questionnaire, as listed in the description here.", "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Goldberg, David; Hillier, Valerie (1979). \"A scaled version of the General Health Questionnaire\". Psychological Medicine. Cambridge University Press. 9 (01): 139–145." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "GHQ" ; a owl:Class ; rdfs:label "General Health Questionnaire (GHQ)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0000442 obo:IAO_0000115 "The GAD-7 is a self-administered patient questionnaire used as a screening tool and severity measure for generalised anxiety disorder. The GAD-7 score is calculated by assigning scores of 0, 1, 2, and 3, to the response categories of 'not at all', 'several days', 'more than half the days', and 'nearly every day', respectively, and adding together the scores for the seven questions. Scores of 5, 10, and 15 are taken as the cut-off points for mild, moderate and severe anxiety, respectively. When used as a screening tool, further evaluation is recommended when the score is 10 or greater." ; obo:SCDO_0000340 "Spitzer RL, Kroenke K, Williams JB, et al; A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine. 2006;166(10):1092-7." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasDbXref "NCIT:C88893" ; oboInOwl:hasExactSynonym "GAD-7", "Generalised Anxiety Disorder Questionnaire" ; a owl:Class ; rdfs:label "Generalised Anxiety Disorder Questionnaire (GAD-7)" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297 . obo:SCDO_0000443 obo:IAO_0000115 "An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D005817" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000443" ; oboInOwl:hasDbXref "MESH:D005817" ; oboInOwl:hasExactSynonym "Prenatal Genetic Counseling" ; a owl:Class ; rdfs:label "Genetic Counseling" ; rdfs:subClassOf obo:SCDO_0000447, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000032 ] . obo:SCDO_0000444 obo:IAO_0000115 "A biological disease modifier that is of a genetic nature." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Genetic Disease Modifier" ; rdfs:subClassOf obo:SCDO_0000122, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:OGMS_0000047 ] . obo:SCDO_0000447 obo:IAO_0000115 "Organized services to provide diagnosis, treatment, and prevention of genetic disorders." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D033142" ; obo:SCDO_1000288 "Sufficiient" ; oboInOwl:hasDbXref "MESH:D033142" ; oboInOwl:hasExactSynonym "Genetic Services" ; a owl:Class ; rdfs:label "Genetic Service" ; rdfs:subClassOf obo:SCDO_0000922 . obo:SCDO_0000448 obo:IAO_0000115 "Chromosomal, biochemical, intracellular, and other methods used in the study of genetics." ; obo:SCDO_0000303 "This and its sub-classes need work!" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D005821" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000448" ; oboInOwl:hasDbXref "MESH:D005821" ; oboInOwl:hasExactSynonym "Genetic Technic", "Genetic Technics", "Genetic Techniques" ; a owl:Class ; rdfs:label "Genetic Technique" ; rdfs:subClassOf obo:SCDO_0000082 . obo:SCDO_0000454 obo:IAO_0000115 "Elevated ocular pressure caused by clogging of the trabecular meshwork and by impaired aqueous humor outflow from blood in the anterior chamber (due to ocular trauma or surgery)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology as more specific type (sub-class) of glaucoma." ; obo:SCDO_0000340 "Ballas et al 2010 Am J Hematol" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Glaucomas" ; a owl:Class ; rdfs:label "Glaucoma (Secondary to Presence of Blood in the Anterior Chamber of the Eye)" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C101217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:SCDO_0000455 obo:IAO_0000115 "A test to assess the respondent's overall mental capability." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000455" ; oboInOwl:hasDbXref "phenX:130700" ; a owl:Class ; rdfs:label "Global Mental Status Screener" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033 . obo:SCDO_0000456 obo:IAO_0000115 "A genetic locus responsible for the encoding of globins." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps below \"Genetic Locus\" in MESH." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Globin Locus" ; rdfs:subClassOf obo:SCDO_1000103 . obo:SCDO_0000457 obo:IAO_0000115 "Measurement of the flow rate of filtered fluid through the kidney, calculated either by comparative measurements of substances in the blood and urine, or estimated from a blood test." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_0005208" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000457" ; oboInOwl:hasDbXref "EFO:0005208" ; oboInOwl:hasExactSynonym "GFR" ; a owl:Class ; rdfs:label "Glomerular Filtration Rate" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000462 obo:IAO_0000115 "This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene." ; obo:SCDO_0000303 "Exists in other ontologies but we have provided a description more relevant to its relationship with SCD." ; obo:SCDO_0000340 "http://www.ncbi.nlm.nih.gov/gene/2539" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; oboInOwl:hasExactSynonym "G-6-PD", "G6PD1", "Glucose-6-Phosphate 1-Dehydrogenase Gene", "Glucose-6-Phosphate Dehydrogenase Gene" ; a owl:Class ; rdfs:label "G6PD" ; rdfs:subClassOf obo:SCDO_0000810 . obo:SCDO_0000465 obo:IAO_0000115 "A deficiency or slowing down of growth pre- and postnatally greater than two standard deviations from the age- and sex-related normal." ; obo:SCDO_0000303 "Suggest update to description in HPO." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001510" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0001510" ; oboInOwl:hasExactSynonym "Delayed Growth", "Growth Deficiency", "Growth Failure", "Growth Retardation", "Poor Growth", "Retarded Growth" ; a owl:Class ; rdfs:label "Growth Delay" ; rdfs:subClassOf obo:HP_0001507, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000262 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000466 obo:IAO_0000115 "A bioassay to measure haptoglobin, which is produced by the liver and transports hemoglobin to the liver for recycling." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Haptoglobin Level\")." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:10801" ; a owl:Class ; rdfs:label "Haptoglobin Blood Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:CMO_0002520 ] . obo:SCDO_0000468 obo:IAO_0000115 "A relation between a disease and the age, developmental stage, or period of life at which the disease or the initial symptoms or manifestations of the disease usually appear in individuals." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. This property might be better suited as a data property? If as a data property, perhaps there should be a standardised way of inputting age of onset?""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "has age of onset" . obo:SCDO_0000469 obo:IAO_0000115 "A relationship between a condition (phenotype or disease) and a relevant ICD-10-CM Diagnosis Code." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has clinical code" . obo:SCDO_0000470 obo:IAO_0000115 "A relation between a measure (e.g. a survey) and how the measure has been adapted cross-culturally." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. Should be restricted to all measure/questionnaire classes.""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "has cross-cultural adaptation" . obo:SCDO_0000472 obo:IAO_0000115 "A relationship between a condition/disease and a description of how the condition/disease is staged/graded." ; obo:SCDO_0000303 "Requested inclusion of this property into RO. Check details here again after inclusion." ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:comment "Staging provided is disease/phenotype specific." ; rdfs:label "has disease stage" . obo:SCDO_0000474 obo:IAO_0000115 "A relation between a device (diagnostic device) and the recording of the output (diagnostic measurement) of the device." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has output measurement" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_0000475 obo:IAO_0000115 "A relation between a process (e.g. a form of therapy) and a medical device, where the medical device is used in the process." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "uses medical device" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_0000479 obo:IAO_0000115 "A relation between a measurement and a plan specification for obtaining the measurement that has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. To be applied to \"Measurement\", \"Test, Method or Assay\", \"Therapeutics\"""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "has protocol" . obo:SCDO_0000480 obo:IAO_0000115 "A relation between a measure or measurement and the recommended procedure used by the measure or used to obtain the measurement." ; obo:SCDO_0000303 "Requested inclusion of this property into RO. Check details here again after inclusion." ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "has recommended procedure" . obo:SCDO_0000481 obo:IAO_0000115 "A relation between a measure (e.g. a survey) and the measure's respondents (people who respond). Respondents can be types or groups of people or people with a specific relationship to the main person of interest in the measure." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. Should be restricted to all measure/questionnaire classes.""" ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:comment "If the main person of interest responds, \"Self\" is indicated. If a person other than the main person of interest can respond, \"Proxy\" is indicated. If the proxy responder has a specific relationship (Family Members; Health Care Provider or Care-giver) to the main person of interest, that relationship should be indicated in brackets after \"Proxy\", e.g. Proxy (Health Care Provider or Care-giver). If more than one type of proxy responder is relevant, these should be listed and separated by \";\", e.g. Proxy (Family Members; Health Care Provider or Care-giver)" ; rdfs:label "has respondents" . obo:SCDO_0000482 obo:IAO_0000115 "A relation between a measure (e.g. a survey) and the population that the measure was designed to target." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. Should be restricted to all measure/questionnaire classes.""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:comment "Possible values used in the SCDO: Healthy Population; Clinic Patients (Children and/or Adults with SCD); Family Members; and/or Health Care Provider" ; rdfs:label "has target population" . obo:SCDO_0000484 obo:IAO_0000115 "An account of known translations of a measure into other languages (other than English)." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. Should be restricted to all measure/questionnaire classes.""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "has translations" . obo:SCDO_0000486 obo:IAO_0000115 "A relation between a planned process and an objective it can be used to achieve." ; obo:SCDO_0000303 "Requested inclusion of this property into RO. Check details here again after inclusion.", "This property is originally an object property." ; obo:SCDO_0000340 ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; a owl:AnnotationProperty ; rdfs:label "has_application_toward" . obo:SCDO_0000487 obo:IAO_0000115 "Individual lifestyle and behavior which may or may not enhance or maintain good health." ; obo:SCDO_0000303 """Suggest the NCIT updates their description for this term to include negative /risk inreasing behaviour? Include: -- gaining better control of your diabetes -- lowering cholesterol -- lowering blood pressure -- maintaining a healthy body weight -- eating a balanced diet -- Include these from MESH: -- Treatment Refusal -- Vaccination Refusal""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000487" ; oboInOwl:hasDbXref "APAONTO:Health_Behavior" ; oboInOwl:hasExactSynonym "Health Behavior" ; a owl:Class ; rdfs:label "Health Behaviour" ; rdfs:subClassOf obo:SCDO_0000435 . obo:SCDO_0000488 obo:IAO_0000115 "People's beliefs about health problems, perceived benefits of action and barriers to action, and self-efficacy." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:source , "Health-Belief Model" ; a owl:Class ; rdfs:comment "The health belief model suggests that health beliefs explain engagement (or lack of engagement) in health-promoting behaviour." ; rdfs:label "Health Beliefs" ; rdfs:subClassOf obo:SCDO_0000299 . obo:SCDO_0000489 obo:IAO_0000115 "Health financing is concerned with how financial resources are generated, allocated and used in health systems. Health financing policy focuses on how to move closer to universal coverage with issues related to: (i) how and from where to raise sufficient funds for health; (ii) how to overcome financial barriers that exclude many poor from accessing health services; or (iii) how to provide an equitable and efficient mix of health services." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Health Care Resources", "Healthcare Resources" ; a owl:Class ; rdfs:label "Health Financing" ; rdfs:subClassOf obo:SCDO_0000494 . obo:SCDO_0000490 obo:IAO_0000115 "Whether the respondent is covered by health insurance or some other form of health care coverage at the time of the interview." ; obo:SCDO_0000303 """Suggest inclusion into MESH. The phenX term is actually referring to a protocol for collecting data on Health Insurance Coverage. The protocol is somewhat U.S. specific. Should probably be modified to be more relevant to the African setting.""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Health Insurance Coverage #11502" ; obo:SCDO_1000288 "Negligable" ; a owl:Class ; rdfs:comment "Also applicable to a population not just to an individual." ; rdfs:label "Health Insurance Coverage" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0000496, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000491 obo:IAO_0000115 "Degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D057220" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000491" ; oboInOwl:hasDbXref "MESH:D057220" ; oboInOwl:hasExactSynonym "Knowledge about Sickle Cell Disease" ; oboInOwl:hasNarrowSynonym "Genetic Counseling" ; a owl:Class ; rdfs:label "Health Literacy" ; rdfs:subClassOf obo:SCDO_0000286 . obo:SCDO_0000492 obo:IAO_0000115 "Health data accessible to the patient and others." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D055991" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000492" ; oboInOwl:hasDbXref "MESH:D055991" ; oboInOwl:hasExactSynonym "Health Records, Personal", "Personal Health Information", "Personal Health Record", "Personal Health Records", "Personal Medical Record", "Personal Medical Records" ; a owl:Class ; rdfs:label "Health Records" ; rdfs:subClassOf obo:SCDO_0000738 . obo:SCDO_0000493 obo:IAO_0000115 "The measure of the population's use of the health care services available to them. This includes the utilization of hospital resources, Personal Care Home (PCH) resources, and physician resources. Health care utilization and health status are used to examine how efficiently a health care system produces health in a population." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source ; oboInOwl:hasExactSynonym "Health Care Service Utilization", "Health Care Utitlization", "Healthcare Utitlization" ; a owl:Class ; rdfs:label "Health Service Utilization" ; rdfs:subClassOf obo:SCDO_0000948 . obo:SCDO_0000494 obo:IAO_0000115 "A system responsible for delivering services that improve, maintain or restore the health of individuals and their communities. This includes the care provided by hospitals and family doctors, but also less visible tasks such as the prevention and control of communicable disease, health promotion, health workforce planning and improving the social, economic or environmental conditions in which people live." ; obo:SCDO_0000303 "Suggest update to description in Medline Plus Health Topics" ; obo:SCDO_0000340 "http://www.euro.who.int/en/health-topics/Health-systems/pages/health-systems" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasExactSynonym "Health Care Delivery", "Health Care System", "Health Care Systems" ; a owl:Class ; rdfs:label "Health System" ; rdfs:subClassOf obo:SCDO_0000948 . obo:SCDO_0000495 obo:IAO_0000115 "Utility measures of health related quality of life are preference values that patients attach to their overall health status. In clinical trials, utility measures summarize both positive and negative effects of an intervention into one value between 0 (equal to death) and 1 (equal to perfect health). These measures allow for comparison of patient outcomes of different diseases, and for comparison between various health care interventions. There are 2 different approaches to utility measurement." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.ncbi.nlm.nih.gov/pubmed/7674256" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Health Utility Index", "Health Utility Measure" ; a owl:Class ; rdfs:label "Health Utility" ; rdfs:subClassOf obo:SCDO_0000948 . obo:SCDO_0000496 obo:IAO_0000115 "The ease with which an individual can obtain needed medical services." ; obo:SCDO_0000303 """Additional WG note: organization of health system [insurance]; electronic (portable) health records; special issues related to pain and pain medications; levels of care (primary, secondary, tertiary) (Location – [rural/urban; mobile units]; hours; affordability; timeliness). Availability of personnel. Equipment treatments other resources""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO" ; dc:source , ; oboInOwl:hasExactSynonym "Access to Healthcare", "Health Care Access" ; a owl:Class ; rdfs:comment "The WHO Constitution envisages \"...the highest attainable standard of health as a fundamental right of every human being.\" The right to health includes access to timely, acceptable, and affordable health care of appropriate quality." ; rdfs:label "Healthcare Access" ; rdfs:subClassOf obo:SCDO_0000948 . obo:SCDO_0000497 obo:IAO_0000115 "Dietary patterns which have been found to be important in reducing disease risk." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000072001" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000497" ; oboInOwl:hasDbXref "MESH:D000072001" ; oboInOwl:hasExactSynonym "Healthy Eating" ; a owl:Class ; rdfs:label "Healthy Diet" ; rdfs:subClassOf obo:NCIT_C15900, obo:SCDO_0000487, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000819 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000855 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000938 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001513 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002076 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002138 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003611 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001168 ] . obo:SCDO_0000498 obo:IAO_0000115 "A pattern of behavior involving lifestyle choices which ensure optimum health. Examples are eating right; maintaining physical, emotional, and spiritual wellness, and taking preemptive steps against communicable diseases." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000070497" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000498" ; oboInOwl:hasDbXref "MESH:D000070497" ; oboInOwl:hasExactSynonym "Healthy Life Style" ; a owl:Class ; rdfs:label "Healthy Lifestyle" ; rdfs:subClassOf obo:SCDO_0000689, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000855 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000938 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002870 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003611 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001168 ] . obo:SCDO_0000500 obo:IAO_0000115 "Examinations used to diagnose and treat heart conditions." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006334" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000500" ; oboInOwl:hasDbXref "MESH:D006334" ; oboInOwl:hasExactSynonym "Heart Function Tests", "Pulmonary Function Test" ; a owl:Class ; rdfs:label "Heart Function Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:SCDO_0000501 obo:IAO_0000115 "The number of times the heart ventricles contract per unit of time, usually per minute." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_0004326" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000501" ; oboInOwl:hasDbXref "EFO:0004326" ; oboInOwl:hasExactSynonym "Heart Beat", "Pulse", "Pulse Rate" ; a owl:Class ; rdfs:label "Heart Rate" ; rdfs:subClassOf obo:SCDO_1000317, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000502 obo:IAO_0000115 "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart valves." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Perhaps below \"Heart Measurement\" in the CMO. Can add sub-classes as per the measurements given in the Diagnostic Criteria below the Protocol section in PhenX for \"Heart Valve Function\". Sub-classes that are also morphological measurements can be included below \"Body Morphological Measurement\"""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Heart Valve Measurement" ; rdfs:subClassOf obo:SCDO_1000317, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000409 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0000410 ] . obo:SCDO_0000504 obo:IAO_0000115 "A measurement device used to perform complete blood counts, erythrocyte sedimentation rates (ESRs), or coagulation tests." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0000494" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000504" ; oboInOwl:hasDbXref "ERO:0000494" ; oboInOwl:hasExactSynonym "Haematology Analyser" ; a owl:Class ; rdfs:label "Hematology Analyzer" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000474 ; owl:someValuesFrom obo:CMO_0000025 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000474 ; owl:someValuesFrom obo:CMO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000474 ; owl:someValuesFrom obo:CMO_0000029 ] . obo:SCDO_0000505 obo:IAO_0000115 "A test to detect potential blood disorders or diseases in people who do not have any symptoms of disease." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Haematology Screening Test" ; a owl:Class ; rdfs:label "Hematology Screening Test" ; rdfs:subClassOf obo:SCDO_0000133 . obo:SCDO_0000506 obo:IAO_0000115 "Transfer of hematopoietic stem cells from bone marrow or blood between individuals within the same species (transplantation, homologous) or transfer within the same individual (transplantation, autologous). Hematopoietic stem cell transplantation has been used as an alternative to bone marrow transplantation in the treatment of a variety of neoplasms." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018380" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000506" ; oboInOwl:hasDbXref "MESH:D018380" ; oboInOwl:hasExactSynonym "BMT", "Bone Marrow Transplant", "Hematopoietic SCT" ; a owl:Class ; rdfs:label "Hematopoietic Stem Cell Transplantation" ; rdfs:subClassOf obo:SCDO_0000301, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002665 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000518 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000519 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_1000077 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_1000078 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000507 obo:IAO_0000115 "The blood-making organs and tissues, principally the bone marrow and lymph nodes." ; obo:IAO_0100001 obo:SCDO_1000264 ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006413" ; oboInOwl:hasDbXref "MESH:D006413" ; a owl:Class ; rdfs:label "deprecated Hematopoietic System" ; rdfs:subClassOf obo:SCDO_0000511 ; owl:deprecated true . obo:SCDO_0000508 obo:IAO_0000115 "Presence of blood in the urine." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006417" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000508" ; oboInOwl:hasDbXref "MESH:D006417" ; oboInOwl:hasExactSynonym "Blood in Urine", "Hematurias" ; a owl:Class ; rdfs:label "Hematuria" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0000510 obo:IAO_0000115 "This gene encodes the enzyme, heme oxygenase 1, an essential enzyme in heme catabolism and cellular homeostasis." ; obo:SCDO_0000303 "Suggest update to description in NCIT (for \"HMOX1 Gene\")" ; obo:SCDO_0000340 , "http://www.ncbi.nlm.nih.gov/gene/3162" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasExactSynonym "HMOX1 Gene", "HO-1", "HO1 Gene", "Heat Shock Protein, 32-kD Gene", "Heme Oxygenase (Decycling) 1 Gene", "Heme Oxygenase 1 gene", "Hemeoxygenase 1 Gene", "Hemoxygenase-1 Gene" ; a owl:Class ; rdfs:label "HMOX1" ; rdfs:subClassOf obo:SCDO_0000810 . obo:SCDO_0000511 obo:IAO_0000115 "Organs involved in the production of BLOOD, including the cellular and the molecular components essential in providing defense against foreign organisms or substances." ; a owl:Class ; rdfs:label "obsolete Hemic and Immune Systems" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000513 obo:IAO_0000115 "A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006444" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000513" ; oboInOwl:hasDbXref "MESH:D006444" ; oboInOwl:hasExactSynonym "Hb C", "HbC", "HbC Hemoglobin" ; a owl:Class ; rdfs:label "Hemoglobin C" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000041 ] . obo:SCDO_0000514 obo:IAO_0000115 "An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006451" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000514" ; oboInOwl:hasDbXref "MESH:D006451" ; oboInOwl:hasExactSynonym "Haemoglobin S", "Hb S", "HbS", "HbS Haemoglobin", "HbS Hemoglobin", "Sickle Haemoglobin", "Sickle Hemoglobin" ; a owl:Class ; rdfs:label "Hemoglobin S" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ] . obo:SCDO_0000515 obo:IAO_0000115 "An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in alpha-thalassemia." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006447" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000515" ; oboInOwl:hasDbXref "MESH:D006447" ; oboInOwl:hasExactSynonym "Hb H", "HbH", "HbH Hemoglobin" ; a owl:Class ; rdfs:label "Hemoglobin H" ; rdfs:subClassOf obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001386 ] . obo:SCDO_0000516 obo:IAO_0100001 obo:SCDO_1000698 ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "deprecated Hemoglobin A2 Profile" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000517 obo:IAO_0000115 "An abnormal hemoglobin, composed of four gamma globin chains, causing it to have an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues." ; obo:SCDO_0000303 "Additional info from the definition in HPO: \"Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues.\"", "Suggest update to description in HP as we have done." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0005507" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0005507" ; oboInOwl:hasExactSynonym "Haemoglobin Bart's", "Haemoglobin Barts", "Hb Bart's", "Hb Barts", "Hemoglobin Bart's" ; a owl:Class ; rdfs:label "Hemoglobin Barts" ; rdfs:subClassOf obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001387 ] . obo:SCDO_0000518 obo:IAO_0000115 "The most severe form of alpha-thalassemia and is almost always lethal, and characterized by fetal onset of generalized edema, pleural and pericardial effusions, and severe hypochromic anemia. It is caused by the presence of Hemoglobin Barts, a hemoglobin with four gamma chains, which has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues" ; obo:SCDO_0000303 "Suggest update to description in ORDO as we have done." ; obo:SCDO_0000340 "http://www.orpha.net/ORDO/Orphanet_163596" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "Orphanet:163596" ; oboInOwl:hasExactSynonym "Alpha-Thalassemia Hydrops Fetalis", "Alpha-Thalassemia Major", "Haemoglobin Barts Hydrops Fetalis", "Hb Barts", "Hb Barts Syndrome", "Hemoglobin Bart's Hydrops Fetalis", "Hemoglobin Barts Hydrops Fetalis Syndrome", "Homozygous Alpha 0-Thalassemia" ; a owl:Class ; rdfs:label "Hemoglobin Barts Hydrops Fetalis" ; rdfs:subClassOf obo:SCDO_0000042, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0003894 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0006589 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C15238 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0008888 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_0001387 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001387 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000241 ] . obo:SCDO_0000519 obo:IAO_0000115 "An autosomal recessive disorder resulting from the production of hemoglobin C, secondary to an amino acid substitution of lysine for glutamic acid in the sixth position of the beta chain (E6K), and characterized by mild hemolytic anemia and occasionally jaundice, though most patients are asymptomatic." ; obo:SCDO_0000303 "Suggest update to description in NCIT" ; obo:SCDO_0000340 obo:NCIT_C34675, "http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-C" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C34675" ; oboInOwl:hasExactSynonym "Haemoglobin C Disease", "Hb C-Disease" ; a owl:Class ; rdfs:label "Hemoglobin C Disease" ; rdfs:subClassOf obo:SCDO_0008262, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CHMO_0001009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001329 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000242 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000232 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001878 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000513 ] . obo:SCDO_0000520 obo:IAO_0000115 "The inheritance of the gene for hemoglobin C from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." ; obo:SCDO_0000340 "http://www.sickle-thal.nwlh.nhs.uk/blood/haemoglobinc.aspx" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasExactSynonym "Haemoglobin C-A Disorder", "Hb AC", "Hemoglobin C-A Disorder", "Heterozygous for Hb C" ; a owl:Class ; rdfs:label "Hemoglobin C Trait" ; rdfs:subClassOf obo:NCIT_C95534, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000225 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C3833 ] . obo:SCDO_0000521 obo:IAO_0000115 "'A form of beta-thalassemia with a phenotype of mild to moderate hemolytic anemia. Patients are often asymptomatic but if present symptoms include anemia and enlarged spleen.'" ; obo:SCDO_0000303 "The description could be more detailed." ; obo:SCDO_0000340 "http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=231242" ; oboInOwl:hasExactSynonym "Hb C-Beta Thalassemia Syndrome", "Hemoglobin C Beta-Thalassemia" ; a owl:Class ; rdfs:label "deprecated Hemoglobin C-Beta Thalassemia" ; rdfs:subClassOf obo:SCDO_0000272 ; owl:deprecated true . obo:SCDO_0000522 obo:IAO_0000115 "A test to measure the presence and amount of a variant of hemoglobin in the blood." ; obo:SCDO_0000303 "Many terms below \"Hemoglobin Variant Test\" in SNOMED CT could be added.", """Suggest update to label and description in NCIT (from \"Hemoglobin Variant Measurement\" and \"A test to measure the variants of hemoglobin.\") It is not clear whether this term was is in fact a synonym of \"Hemoglobin Profile Assay\". We assumed it wasn't. If it actually is, we need to address the ambiguity caused.""" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C103845" ; obo:SCDO_1000288 "Suggest update to label and description" ; oboInOwl:hasDbXref "NCIT:C103845" ; oboInOwl:hasExactSynonym "Haemoglobin Variant Observation", "Haemoglobin Variant Test", "Haemoglobinopathy Screen", "Hemoglobin Variant Measurement", "Hemoglobin Variant Observation", "Hemoglobinopathy Screen" ; a owl:Class ; rdfs:label "Hemoglobin Variant Test" ; rdfs:subClassOf obo:SCDO_0000133 . obo:SCDO_0000524 obo:IAO_0000115 "An autosomal recessive hemoglobinopathy characterized by production of abnormal variant hemoglobin known as hemoglobin D, with no or mild clinical manifestations (splenomegaly, very mild anemia)." ; obo:SCDO_0000303 "Suggest update to description in ORDO" ; obo:SCDO_0000340 , "http://www.doh.wa.gov/Portals/1/Documents/5220/HbDFactSheet.pdf" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "DOID:5378" ; oboInOwl:hasExactSynonym "Hb DD", "Homozygous Hemoglobin D" ; a owl:Class ; rdfs:label "Hemoglobin D Disease" ; rdfs:subClassOf obo:SCDO_0008262, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000108 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000113 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_0000525 obo:IAO_0000115 "The inheritance of the gene for hemoglobin D from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." ; obo:SCDO_0000340 "http://www.doh.wa.gov/Portals/1/Documents/5220/HbDFactSheet.pdf" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hb AD" ; a owl:Class ; rdfs:label "Hemoglobin D Trait" ; rdfs:subClassOf obo:NCIT_C95534, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000108 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000113 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000115 ] . obo:SCDO_0000526 obo:IAO_0000115 "'Hemoglobin D/xcexb2xc2xb0 thalassemia is a form of beta-thalassemia which results in a mild to moderate clinical picture. The severity of the condition depends on the degree of thalassemia and how it affects production of Hemoglobin A, however this condition is often considered fairly benign.'" ; obo:SCDO_0000340 "http://www.doh.wa.gov/Portals/1/Documents/5220/HbDFactSheet.pdf" ; oboInOwl:hasExactSynonym "HbD - BT", "Hemoglobin D Beta-Thalassemia" ; a owl:Class ; rdfs:label "deprecated Hemoglobin D-Beta Thalassemia" ; rdfs:subClassOf obo:SCDO_0000272 ; owl:deprecated true . obo:SCDO_0000527 obo:IAO_0000115 "An unusual hemoglobin that shows all the electrophoretic features of Hb D, but has no inherited disability. This hemoglobin has a beta 87 Thr > Lys mutation." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Hemoglobin Variant\"/\"Unusual Hemoglobin\"." ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Hemoglobin D (badan)" ; a owl:Class ; rdfs:label "Hemoglobin D-Ibadan" ; rdfs:subClassOf obo:SCDO_1000259 . obo:SCDO_0000528 obo:IAO_0000115 "An abnormal hemoglobin (one of the types of hemoglobin D) in which glutamine replaces glutamic acid at codon 121 of beta globin." ; obo:SCDO_0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"/\"Hemoglobin D\"." ; obo:SCDO_0000340 "http://health.utah.gov/nsp/Disorders/HB/Hb_D_Disease_DD/FactSheet_Provider_HbDD_En.pdf" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Haemoglobin D-Punjab", "Hb D-Los Angelese", "Hb D-Punjab", "Hemoglobin D (Chicago)", "Hemoglobin D (Los Angeles)", "Hemoglobin D (North Carolina)", "Hemoglobin D (Portugal)", "Hemoglobin D (Punjab)", "Hemoglobin Oak Ridge" ; a owl:Class ; rdfs:label "Hemoglobin D-Punjab" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_1000007, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000109 ] . obo:SCDO_0000529 obo:IAO_0000115 "A disease caused by atypical hemoglobins molecules other than hemoglobin C,D,E, F, H, O-Arab and S." ; obo:SCDO_0000303 "adapted from description under ID SCDO:0001065" ; obo:SCDO_0000340 "SCDO:0001065", "http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-and-other-than-A-C-D-E-F-H-O-Arab-S" ; a owl:Class ; rdfs:label "deprecated Hemoglobin Disease Other than C,D,E,F,H,O-Arab,S" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000530 obo:IAO_0000115 """An autosomal recessive haemoglobinopathy characterized by an abnormal form of haemoglobin called haemoglobin E, which disrupts the oxygen-carrying ability of red blood cells. The condition can lead to mild or moderate hemolytic anemia; however, this condition often has no clinical manifestations. with a generally benign, asymptomatic presentation.""" ; obo:SCDO_0000340 , "http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-E" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000530" ; oboInOwl:hasDbXref "ORPHA:2133" ; oboInOwl:hasExactSynonym "Haemoglobin E Disease", "Hb E-Disease" ; a owl:Class ; rdfs:label "Hemoglobin E Disease" ; rdfs:subClassOf obo:SCDO_0008262, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CHMO_0001009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001329 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000242 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000229 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C3833 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000009 ] . obo:SCDO_0000531 obo:IAO_0000115 "The inheritance of the gene for hemoglobin E from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." ; obo:SCDO_0000340 "http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-A-E" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; dc:source ; oboInOwl:hasExactSynonym "Hb AE", "Hb E Trait" ; a owl:Class ; rdfs:comment "Hb E-carriers generally do not have any signs or symptoms related to abnormal hemoglobin." ; rdfs:label "Hemoglobin E Trait" ; rdfs:subClassOf obo:NCIT_C95534, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000227 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000042 ] . obo:SCDO_0000532 obo:IAO_0000115 "'Hemoglobin E/xcexb2+ thalassemia is a form of beta-thalassemia that is often, but not always, milder than hemoglobin E/xcexb2xc2xb0 thalassemia. This condition shows a marked clinically diverse picture whereby abnormalities of xcexb2-globin chain synthesis result almost asymptomatic anemia to more severe transfusion-dependant anemia (Vichinsky, 2007).'" ; obo:SCDO_0000340 "http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=19177&Disease_Disease_Search_diseaseGroup=Hemoglobin-D-Beta-Thalassemia&Disease_Disease_Search_diseaseType=Pat&Disease(s)/group%20of%20diseases=Hemoglobin-E-beta-thalassemia-syndrome&title=Hemoglobin-E-beta-thalassemia-syndrome&search=Disease_Search_Simple" ; oboInOwl:hasExactSynonym "Haemoglobin E-Beta Thalassemia", "Hemoglobin E Beta-Thalassemia" ; a owl:Class ; rdfs:label "deprecated Hemoglobin E-Beta Thalassemia" ; rdfs:subClassOf obo:SCDO_0000272 ; owl:deprecated true . obo:SCDO_0000533 obo:IAO_0000115 "The score of fetal hemoglobin (Hb F) in the blood of an individual." ; obo:IAO_0100001 obo:SCDO_1000707 ; obo:SCDO_0000303 "Description not clear enough." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Gaston K Mazandu)" ; a owl:Class ; rdfs:label "deprecated Hemoglobin F Profile" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000535 obo:IAO_0000115 "A variant of Hemoglobin Lepore Syndrome." ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome" ; oboInOwl:hasExactSynonym "Hb Lepore Baltimore" ; a owl:Class ; rdfs:label "obsolete Hemoglobin Lepore Baltimore" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000536 obo:IAO_0000115 "A variant of Hemoglobin Lepore Syndrome. Crossover occurs between glutamine at position 87 of delta chain and histidine at position 116 of beta chain. It is associated with unusual high levels of Hb F. This is the only one of the three variants of described in association with HbS." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Hb Lepore Boston Syndrome", "Hb Lepore Washington Syndrome", "Hb Lepore Washington-Boston Syndrome", "Hemoglobin Lepore Boston-Washington", "Hemoglobin Lepore Washington Syndrome", "Hemoglobin Lepore Washington-Boston Syndrome" ; a owl:Class ; rdfs:label "Hemoglobin Lepore Boston Disease" ; rdfs:subClassOf obo:NCIT_C141366, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CHMO_0001009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000666 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000236 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000089 ] . obo:SCDO_0000537 obo:IAO_0000115 "A variant of Hemoglobin Lepore Syndrome." ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome" ; oboInOwl:hasExactSynonym "Hb Hollandia" ; a owl:Class ; rdfs:label "obsolete Hemoglobin Lepore Hollandia" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000539 obo:IAO_0000115 "The inheritance of the gene for hemoglobin Lepore from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Heterozygous Hb Lepore" ; a owl:Class ; rdfs:label "Hemoglobin Lepore Trait" ; rdfs:subClassOf obo:SCDO_0000551, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C3833 ] . obo:SCDO_0000540 obo:IAO_0000115 "'A form of beta-thalassemia in which the patient is compound heterozygous for hemoglobin lepore and beta-thalassemia, which results in beta-thalassemia intermedia to beta-thalassemia major. [Curator team: []]'" ; obo:SCDO_0000303 "Add HBD to Disease Modifiers (below Gene Product)? And link to it." ; oboInOwl:hasExactSynonym "Hb Lepore-B-Thalassaemia", "Hemoglobin Lepore-B-Thalassaemia", "Hemoglobin Lepore-Beta Thalassaemia Syndrome" ; a owl:Class ; rdfs:label "deprecated Hemoglobin Lepore-Beta Thalassaemia" ; rdfs:subClassOf obo:SCDO_0000272 ; owl:deprecated true . obo:SCDO_0000541 obo:IAO_0000115 "A type of dominant hereditary methemoglobinemia resulting from the production of hemoglobin M, which is readily oxidised to yield excess methemoglobin which leads to cyanosis." ; obo:SCDO_0000303 "Suggest update to description in MESH" ; obo:SCDO_0000340 , , "http://medlineplus.gov/ency/article/000562.htm" ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Autosomal Dominant Congenital Methemoglobinemia Type II", "Autosomal Dominant Hereditary Methemoglobinemia Type II", "Hereditary MetHb Type II", "Hereditary Methemoglobinemia Type II", "M Hemoglobinopathy", "Second Form of Inherited MetHb" ; a owl:Class ; rdfs:label "Hemoglobin M Disease" ; rdfs:subClassOf obo:SCDO_0000559, obo:SCDO_0008262, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000436 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000006 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000233 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000008 ] . obo:SCDO_0000542 obo:SCDO_0000303 "Hemoglobin M Disease is autosomal dominant, thus does not seem to have a \"trait\" condition.", "Requires definition and source." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "obsolete - Hemoglobin M Trait" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0000544 obo:IAO_0000115 "A very rare autosomal recessive hemoglobinopathy characterized by an abnormal form of hemoglobin called hemoglobin O-Arab. It is associated with a mild to moderate anemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "http://onlinelibrary.wiley.com/doi/10.1002/pbc.24414/pdf" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Hb O-Arab Disease", "Homozygous Hb O-Arab", "Homozygous Hemoglobin O-Arab" ; a owl:Class ; rdfs:label "Hemoglobin O-Arab Disease" ; rdfs:subClassOf obo:SCDO_0008262, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000242 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000231 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000040 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000016 ] . obo:SCDO_0000545 obo:IAO_0000115 "The inheritance of hemoglobin O-Arab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." ; obo:SCDO_0000340 "http://onlinelibrary.wiley.com/doi/10.1002/pbc.24414/pdf" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Hb A/O-Arab", "Hb AO-Arab", "Heterozygous Hb O-Arab", "Heterozygous Hemoglobin O-Arab" ; a owl:Class ; rdfs:label "Hemoglobin O-Arab Trait" ; rdfs:subClassOf obo:NCIT_C95534, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000228 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000040 ] . obo:SCDO_0000546 obo:IAO_0000115 "The type and relative amounts of various normal and abnormal hemoglobin types." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "http://labtestsonline.org/understanding/analytes/sickle/tab/test/" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Hemoglobin Profile" ; rdfs:subClassOf obo:CMO_0000508, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ] . obo:SCDO_0000547 obo:IAO_0000115 "A bioassay that measures and identifies the different types of hemoglobin in the bloodstream. It can be used to identify and characterize the different variants in structure and synthesis of hemoglobin that cause sickle cell disease." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Hemoglobin Characterization #830301" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000547" ; oboInOwl:hasDbXref "phenX:830301" ; oboInOwl:hasExactSynonym "Haemoglobin Characterization", "Haemoglobinopathy Screen", "Hb Electrophoresis Plus Solubility", "Hemoglobin Characterization", "Hemoglobin Electrophoresis", "Hemoglobin Electrophoresis plus Solubility", "Hemoglobin Fractionation", "Hemoglobinopathy Evaluation", "Hemoglobinopathy Evaluation Profile Blood Test", "Hemoglobinopathy Fractionation Profile Blood Test", "Hemoglobinopathy Screen" ; a owl:Class ; rdfs:label "Hemoglobin Profile Assay" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000740 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_1000342 ] . obo:SCDO_0000548 obo:IAO_0000115 "A test to quantify the presence of hemoglobin S in the blood and therefore determine whether a person has sickle cell trait or sickle cell disease." ; obo:SCDO_0000303 """In SNOMED CT this term is \"Sickle cell identification\". Request inclusion into relevant ontology.""" ; obo:SCDO_0000340 "http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=31852" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Hemoglobin S Measurement", "Sickle Cell Identification" ; a owl:Class ; rdfs:label "Hemoglobin S Test" ; rdfs:subClassOf obo:SCDO_0000522 . obo:SCDO_0000551 obo:IAO_0000115 "The inheritance of one of the faulty genes that causes thalassemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Thalassemia Trait" ; rdfs:subClassOf obo:NCIT_C95534 . obo:SCDO_0000552 obo:IAO_0000115 "An inherited disorder of the structure and/or synthesis of hemoglobin, with a variable phenotype expression ranging from benign to severe." ; obo:SCDO_0000303 "Suggest update to description in NCIT" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C3092" ; a owl:Class ; rdfs:label "Hemoglobinopathy" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_0000553 obo:IAO_0000115 "Hemoglobinopathy Toms River, is also known as transient neonatal cyanosis and anemia due to toms river hemoglobin. An important gene associated with Hemoglobinopathy Toms River is HBG2 (Hemoglobin Subunit Gamma 2." ; oboInOwl:hasExactSynonym "Anemia due to Toms River Hemoglobin", "Transient Neonatal Cyanosis" ; a owl:Class ; rdfs:label "obsolete Hemoglobinopathy Toms River" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000556 obo:IAO_0000115 "The distance between the lower border of the liver in the mid-clavicular line, and the upper border of the liver in the mid-clavicular line." ; obo:SCDO_0000303 """The description needs to be reviewed by an expert. Request inclusion into Clinical Measurement Ontology, below \"liver size measurement\".""" ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Liver_span" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Liver Span" ; a owl:Class ; rdfs:label "Hepatic Span" ; rdfs:subClassOf obo:CMO_0000021, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000864 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000882 ] . obo:SCDO_0000557 obo:IAO_0000115 "A test for Hepatitis B Virus." ; obo:SCDO_0000303 "Which Hepatitis B Test is to be referred to here? (There are various different types below \"Immunology Test\" in the \"Sage Bionetworks Synapse Ontology\")" ; oboInOwl:hasExactSynonym "HBV Test", "Hepatitis B Virus Test" ; a owl:Class ; rdfs:label "obsolete Hepatitis B Test" ; rdfs:subClassOf obo:SCDO_1000034 ; owl:deprecated true . obo:SCDO_0000558 obo:IAO_0000115 "A test for Hepatitis C Virus." ; obo:SCDO_0000303 "Is this test for viral load measurement or or antibody measurement? (See terms below \"Immunology Test\" in the \"Sage Bionetworks Synapse Ontology\")" ; a owl:Class ; rdfs:label "obsolete Hepatitis C Test" ; rdfs:subClassOf obo:SCDO_1000034 ; owl:deprecated true . obo:SCDO_0000559 obo:IAO_0000115 "A rare red cell disorder classified principally into two clinical phenotypes: autosomal recessive congenital (or hereditary) methemoglobinemia types I and II (RCM/RHM type 1; RCM/RHM type 2)." ; obo:SCDO_0000340 "http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=3290&disease=Hereditary-methemoglobinemia&search=Disease_Search_Simple" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000559" ; oboInOwl:hasDbXref "ORPHA:621" ; oboInOwl:hasExactSynonym "Congenital Methemoglobinemia", "HM", "Hereditary MetHb" ; a owl:Class ; rdfs:label "Hereditary Methemoglobinemia" ; rdfs:subClassOf obo:SCDO_0000753 . obo:SCDO_0000564 obo:IAO_0000115 "Replacement of the hip joint." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D019644" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000564" ; oboInOwl:hasDbXref "MESH:D019644" ; oboInOwl:hasExactSynonym "Hip Prosthesis Implantation", "Hip Replacement Arthroplasty", "Hip Replacements, Total", "Replacement Arthroplasties, Hip", "Total Hip Replacement" ; a owl:Class ; rdfs:label "Hip Replacement Arthroplasty" ; rdfs:subClassOf obo:SCDO_0001129, obo:SCDO_0001133 . obo:SCDO_0000565 obo:IAO_0000115 "A study that compares a group of participants receiving an intervention with a similar group from the past who did not." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D065386" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000565" ; oboInOwl:hasDbXref "MESH:D065386" ; a owl:Class ; rdfs:label "Historically Controlled Study" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000566 obo:IAO_0000115 "A questionnaire to determine whether an individual has had a traumatic brain injury (TBI)." ; obo:SCDO_0000303 "Suggest update to label as we have done. We are using \"History of Head Trauma\" below Personal Attribute." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: History of Head Trauma #130601" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:130600" ; oboInOwl:hasExactSynonym "History of Head Trauma Questionnaire" ; a owl:Class ; rdfs:label "History of Head Trauma Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033 . obo:SCDO_0000567 obo:IAO_0000115 "A questionnaire to determine if the respondent has a history of kidney failure." ; obo:SCDO_0000303 """Link to? -- Kidney Failure -- Personal Attribute---> Personal medical history --> History of Kidney Failure""", "Suggest update to label as we have done. We are using \"History of Kidney Failure\" below Personal Attribute." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Personal History of Kidney Failure #140601" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:140600" ; oboInOwl:hasExactSynonym "History of Kidney Failure Questionnaire" ; a owl:Class ; rdfs:label "History of Kidney Failure Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:CMO_0000003 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000570 ] . obo:SCDO_0000568 obo:IAO_0000115 "A questionnaire to determine if the respondent has had an ischemic infarction (i.e. stroke) and/or any symptoms related to this event." ; obo:SCDO_0000303 "Suggest update to label as we have done. We are using \"History of Stroke\" below Personal Attribute." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: History of Stroke - Ischemic Infarction and Hemorrhage #130301" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:130300" ; oboInOwl:hasExactSynonym "History of Stroke - Ischemic Infarction and Hemorrhage - Questionnaire" ; a owl:Class ; rdfs:label "History of Stroke - Ischemic Infarction and Hemorrhage - Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033 . obo:SCDO_0000570 obo:IAO_0000115 "A questionnaire to determine a respondent's history of type 1 or type 2 diabetes." ; obo:SCDO_0000303 "Link to? -- Personal Attribute---> Personal medical history --> History of Type I and Type 2 Diabetes", "Suggest update to label as we have done. We are using \"History of Type I and Type 2 Diabetes\" below Personal Attribute." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Personal History of Type 1 and Type 2 Diabetes #140501" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:140500" ; a owl:Class ; rdfs:label "History of Type I and Type 2 Diabetes Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000987 ] . obo:SCDO_0000571 obo:IAO_0000115 "A bioassay to measure human immunodeficiency virus (HIV) antibodies and/or HIV antigens in order to determine whether an individual has an HIV infection." ; obo:SCDO_0000303 "Also below \"Immunochemical Assay\"?" ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "HIV Assay", "Human Immunodeficiency Virus Assay", "Human Immunodeficiency Virus Test" ; a owl:Class ; rdfs:label "HIV Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000572 obo:IAO_0000115 "The HADS consists of 2 subscales each with 7 items for measuring anxiety, and 7 items for depression rated from 0 - 3. Anxiety and depression scores are obtained by adding up the ratings of the items on each subscale. A score above 8 in any of the subscales indicates that the patient has experienced clinically significant anxiety or depression over the past week." ; obo:SCDO_0000340 "Zigmond A.S. and Snaith R.P. (1983). The hospital anxiety and depression scale. Acta Psychiatry Scandinavia, 67, 361-370. Anie, K.A.; Green, J.; Tata, P.; Fotopoulos, C. E.; Oni, L. and Davies, S. C. (2002) Self-help manual-assisted cognitive behavioural therapy for sickle cell disease. Behavioural and Cognitive Psychotherapies, 30, 451-458" ; obo:SCDO_0000470 "multiple" ; obo:SCDO_0000481 "Patient Reported Outcome" ; obo:SCDO_0000482 "Clinic Patients" ; obo:SCDO_0001033 "Widely used around the world, also used in SCD" ; obo:SCDO_0001222 "Adults (18 to 91 years)" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source ; oboInOwl:hasDbXref "NCIT:C103520" ; oboInOwl:hasExactSynonym "HADS", "HADS Questionnaire", "HADS01", "Hospital Anxiety and Depression Scale", "Hospital Anxiety and Depression Scale Questionnaire", "Hospital Anxiety and Depression Scale Questionnaire (HADS)" ; a owl:Class ; rdfs:label "Hospital Anxiety and Depression Scale (HADS)" ; rdfs:subClassOf obo:SCDO_0000951, obo:SCDO_1000297 . obo:SCDO_0000573 obo:IAO_0000115 "The confinement of a patient in a hospital." ; obo:SCDO_0000303 "Perhaps \"Hospital Utilization\" would be better here?" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006760" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000573" ; oboInOwl:hasDbXref "MESH:D006760" ; oboInOwl:hasExactSynonym "Hospital Admission", "Hospitalisation", "Hospitalisations", "Hospitalizations" ; a owl:Class ; rdfs:label "Hospitalization" ; rdfs:subClassOf obo:SCDO_0000493 . obo:SCDO_0000574 obo:IAO_0000115 "A record of those living in the respondent's household and about his or her relationship with them." ; obo:SCDO_0000303 "Request inclusion into MESH below \"Social Conditions\"?" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Household Roster-Relationships #11402" ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasDbXref "phenX:11400" ; a owl:Class ; rdfs:label "Household Roster-Relationships" ; rdfs:subClassOf obo:NCIT_C16495, obo:SCDO_0001090, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000307 ] . obo:SCDO_0000576 obo:IAO_0000115 "A unique treatment that administers electrolyte-packed IV fluids directly into a patient's bloodstream. Depending on the patient's needs, the fluid may be enhanced with additives such as calcium, magnesium sulfate or a Vitamin B complex. It is a far more efficient method of absorption when compared to the traditional method of drinking liquids/electrolytes." ; obo:SCDO_0000303 "Suggest update to description in NCIT (currently no description)" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; dc:source ; oboInOwl:hasDbXref "NCIT:C66896" ; a owl:Class ; rdfs:label "Hydration Therapy" ; rdfs:subClassOf obo:NCIT_C15900, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001953 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000812 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000580 obo:IAO_0000115 "An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000580" ; oboInOwl:hasDbXref "MESH:D006918" ; oboInOwl:hasExactSynonym "Hydrea", "Hydroxycarbamide", "Oncocarbide" ; a owl:Class ; rdfs:label "Hydroxyurea" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000251 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_1000707 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C129072 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155312 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000519 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000530 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000972 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000581 obo:IAO_0000115 "A causal adverse drug event that is induced by hydroxyurea." ; obo:SCDO_0000303 "Request inclusion into OAE below \"Causal Adverse Drug Event\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hydroxyurea-Induced Adverse Event" ; rdfs:subClassOf obo:SCDO_0000191, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000199 ; owl:someValuesFrom obo:SCDO_0000580 ] . obo:SCDO_0000582 obo:IAO_0000115 "A hydroxyurea-induced adverse event that has an outcome relating to or affecting the skin." ; obo:SCDO_0000303 """Request inclusion into OAE below \"Hydroxyurea-Induced Adverse Event\" (also suggested by us for inclusion). Or Obsolete and use an object property (has adverse events) to link Hydroxyea to Cutaneous.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hydroxyurea-Induced Cutaneous Adverse Event" ; rdfs:subClassOf obo:SCDO_0000581, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000199 ; owl:someValuesFrom obo:SCDO_0000580 ] . obo:SCDO_0000583 obo:IAO_0000115 "A hydroxyurea-induced adverse event that has the outcome of splenomegaly." ; obo:SCDO_0000303 """Request inclusion into OAE below \"Hydroxyurea-Induced Adverse Event\" (also suggested by us for inclusion). Or Delete and use an object property (has adverse events) to link Hydroxyea to Splenomegaly.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hydroxyurea-Induced Splenomegaly Adverse Event" ; rdfs:subClassOf obo:SCDO_0000581, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000199 ; owl:someValuesFrom obo:SCDO_0000580 ] . obo:SCDO_0000588 obo:IAO_0000115 "Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006947" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000588" ; oboInOwl:hasDbXref "MESH:D006947" ; oboInOwl:hasExactSynonym "High Blood Potassium Levels", "Hyperkalemias", "Hyperpotassemia", "Hyperpotassemias" ; a owl:Class ; rdfs:label "Hyperkalemia" ; rdfs:subClassOf obo:SCDO_0002674, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000593 obo:IAO_0000115 "Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000593" ; oboInOwl:hasDbXref "MESH:D017495" ; oboInOwl:hasExactSynonym "Hypermelanoses", "Hypermelanosis", "Hyperpigmentation of the skin", "Skin Hyperpigmentation" ; a owl:Class ; rdfs:label "Hyperpigmentation" ; rdfs:subClassOf obo:HP_0011121 . obo:SCDO_0000598 obo:IAO_0000115 "Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006993" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000598" ; oboInOwl:hasDbXref "MESH:D006993" ; oboInOwl:hasExactSynonym "Hypnotics", "Sedatives", "Sedatives and Hypnotics" ; a owl:Class ; rdfs:label "Hypnotics and Sedatives" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001129 . obo:SCDO_0000607 obo:IAO_0000115 "The ICD-10-CM diagnosis classification system developed by the Centers for Disease Control and Prevention for use in all U.S. health care treatment settings. Diagnosis coding under this system uses a different number of digits and some other changes, but the format is very much the same as ICD-9-CM. The National Center for Health Statistics (NCHS), the Federal agency responsible for use of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10) in the United States, has developed a clinical modification of the classification for morbidity purposes. The ICD-10 is used to code and classify mortality data from death certificates, having replaced ICD-9 for this purpose as of January 1, 1999. ICD-10-CM is the replacement for ICD-9-CM, volumes 1 and 2, effective October 1, 2015." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps below \"Clinical Coding\" in MESH." ; obo:SCDO_0000340 "https://www.cdc.gov/nchs/icd/icd10cm.htm", "https://www.findacode.com/icd-10-cm/icd-10-cm-diagnosis-codes-set.html" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "ICD-10-CM Diagnosis Codes" ; rdfs:subClassOf obo:SCDO_0000245 . obo:SCDO_0000611 obo:IAO_0000115 "The IPQ-R is an 84-item self-completed instrument developed to provide a quantitative measurement of the components of illness representations, as described by Leventhal's Common-Sense Model (CSM) of selfregulation it is divided into 3 sections: identity subscale (14 symptoms), causal subscale (18 causes), and a third section which contains 7 subscales, including consequences, timeline acute/chronic and cyclical, personal and treatment control/cure, illness coherence, and emotional representations. The questionnaire wording can be adapted to the specific illness by replacing the word illness with the name of the condition. For the identity subscale, respondents are asked if they have experienced a number of symptoms since their illness, and if they feel the symptoms are related to their current illness. Response is by circling 'yes' or 'no' to each question. Responses are then summed to give an overall score. For the causal subscale, respondents are asked what they perceive to be the cause of their illness and are asked to respond to each of the listed causes using a 5-point Likert style scale, ranging from strongly disagree to strongly agree. Respondents are also asked to rank the 3 most important factors believed to be the cause of their illness. The third section (7 subscales) is scored by summing responses to each item is on a 5-point Likert style scale, ranging from strongly disagree to strongly agree. All items for each of the subscales are summed to give an overall score. High scores on the identity, consequences, timeline acute/chronic and cyclical subscales represent strongly held beliefs about the number of symptoms attributed, the negative consequences, and the chronicity and cyclical nature of the illness. High scores on the personal and treatment control and coherence subscales represent positive beliefs about controllability and a personal understanding of the illness." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Moss-Morris R, Weinman J, Petrie KJ, Horne R, Cameron LD, Buick D (2002). The Revised Illness Perception Questionnaire (IPQ-R). Psychol Health 17:1-16." ; obo:SCDO_0000470 "multiple" ; obo:SCDO_0000481 "Patient Reported Outcome" ; obo:SCDO_0000482 "Clinic Patients" ; obo:SCDO_0000484 "many" ; obo:SCDO_0001033 "Good psychometric properties, widely used around the world, has been translated into several languages." ; obo:SCDO_0001222 "Adults" ; obo:SCDO_1000288 "None" ; dc:source "Moss-Morris R, Weinman J, Petrie KJ, Horne R, Cameron LD, Buick D (2002). The Revised Illness Perception Questionnaire (IPQ-R). Psychol Health 17:1-16." ; oboInOwl:hasExactSynonym "IPQ-R", "Illness Perception Questionnaire Revised" ; a owl:Class ; rdfs:label "Illness Perception Questionnaire Revised (IPQ-R)" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0000615 obo:IAO_0000115 "The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components." ; obo:IAO_0100001 obo:SCDO_1000273 ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007107" ; oboInOwl:hasDbXref "MESH:D007107" ; a owl:Class ; rdfs:label "deprecated Immune System" ; rdfs:subClassOf obo:SCDO_0000511 ; owl:deprecated true . obo:SCDO_0000616 obo:IAO_0000115 "An assay that identifies a substance (especially a protein) by its action as an antigen." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Immunochemical Assay" ; rdfs:subClassOf obo:NCIT_C16723 . obo:SCDO_0000618 obo:IAO_0000115 "A drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0001071" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000618" ; oboInOwl:hasDbXref "OAE:0001071" ; a owl:Class ; rdfs:label "Immunosuppressant Drug Level Decreased AE" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000619 obo:IAO_0000115 "An assay that employs immunoturbidimetry, a method that measures the absorbance of light from a sample which is used for quantifying an amount of analyte based on the level of turbidity produced by the formation and precipitation of an immune complex containing the analyte." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. NCIT contains \"Immunoturbidimetry\", but not \"Immunoturbidimetry Assay\". Do we rather want to have this term as \"Immunoturbidimetry\"?" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C106536" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Immunoturbidimetry Test" ; a owl:Class ; rdfs:label "Immunoturbidimetry Assay" ; rdfs:subClassOf obo:NCIT_C16723 . obo:SCDO_0000643 obo:IAO_0000115 "Substances causing insects to turn away from them or reject them as food." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007302" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000643" ; oboInOwl:hasDbXref "MESH:D007302" ; a owl:Class ; rdfs:label "Insect Repellents" ; rdfs:subClassOf obo:SCDO_0000709 . obo:SCDO_0000649 obo:IAO_0000115 "A standardized tool designed to assess a child's development as compared to same-age peers. It has components that involve both direct observation and interaction with a child as well as caregiver questionnaires. It consists of five domains (cognitive, motor, language, social-emotional, and adaptive behavior)." ; obo:SCDO_0000303 "Life stage: Infant, Toddler, Child", "Suggest update to description in NCIT (we're not using their description, but their description says \"from one to twenty-four months of age\")", "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the Bayley-III and the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI - IV). The Working Group recommends that providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for Bayley-III and the WPPSI-IV for guidance on selecting an age-appropriate test." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820504" ; obo:SCDO_0000479 "PhenX protocol: Intelligence Scale - Birth to 3.5 years #820504" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C99150" ; oboInOwl:hasExactSynonym "Bayley Scale of Infant Development III", "Bayley Scales of Infant and Toddler Development, Third Edition", "Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III)", "Bayley-III" ; a owl:Class ; rdfs:label "Intelligence Scale - Birth to 3.5 years" ; rdfs:subClassOf obo:NCIT_C122920 . obo:SCDO_0000650 obo:IAO_0000115 "An adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc)." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0001093" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000650" ; oboInOwl:hasDbXref "OAE:0001093" ; a owl:Class ; rdfs:label "Intentional Drug Misuse AE" ; rdfs:subClassOf obo:SCDO_0000028 . obo:SCDO_0000651 obo:IAO_0000115 "A study that uses observations at multiple time points before and after an intervention (the interruption), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D065186" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000651" ; oboInOwl:hasDbXref "MESH:D065186" ; oboInOwl:hasExactSynonym "ITS Studies" ; a owl:Class ; rdfs:label "Interrupted Time Series Analysis" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000653 obo:IAO_0000115 "Intracerebral hemorrhage (ICH) is when blood suddenly bursts into brain tissue, causing damage to the brain." ; obo:IAO_0100001 obo:SCDO_0000209 ; obo:SCDO_0000303 "Should this term be merged with \"Cerebral Hemorrhage\" and \"Intracerebral Haemorrhage\" made a synonym of \"Cerebral Hemorrhage\"? -- -- Specify description source and source for additional info." ; oboInOwl:hasExactSynonym "Intracerebral Bleeding" ; a owl:Class ; rdfs:label "deprecated-Intracerebral Haemorrhage" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000656 obo:IAO_0000115 "CSF pressure less than 6 cm of H2O in patients with clinical presentation compatible with intracranial hypotension, which are postural headache, nausea, vomiting, neck pain, visual and hearing disturbances, and vertigo. It most commonly results from CSF leaks somewhere along the neuraxis." ; obo:SCDO_0000303 "Suggest update to description in DOID (currently no description)" ; obo:SCDO_0000340 ; obo:SCDO_0000468 "Spontaneous intracranial hypotension is typically encountered in middle age (30-50 years of age) and has a predilection for women (F:M 2:1). Of interest, this is a similar demographic to pseudotumour cerebri, which is believed to be an unrecognised predisposing factor. Epidemiology of secondary intracranial hypotension is variable and matches that of the underlying cause." ; obo:SCDO_0000472 "Intracranial hypotension can broadly be divided into: 1.Primary: usually referred to as spontaneous intracranial hypotension. 2. Secondary: iatrogenic (LP or surgery), over shunting due to diversion devices or traumatic." ; obo:SCDO_0000662 "Generally, there are no localising symptoms forms directly from the leak, as CSF is absorbed into tissues. The condition often presents as a positional headache which is relieved by a recumbent position, usually within 15-30min. It is confirmed by assessing opening pressure on LP (less than 7 cm CSF). Note that when this is done fluoroscopically, it should be performed in a lateral position to allow for accurate measurement of pressure. Occasionally presentation is more sinister, with even decreased level of consciousness and coma reported." ; obo:SCDO_1000288 "Suggest update to description" ; dc:source ; oboInOwl:hasDbXref "DOID:4723" ; oboInOwl:hasExactSynonym "Craniospinal Hypotension", "Decreased Intracranial Pressure" ; a owl:Class ; rdfs:label "Intracranial Hypotension" ; rdfs:subClassOf obo:HP_0012638, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ] . obo:SCDO_0000657 obo:IAO_0000115 "The hydrostatic pressure of venous blood in the marrow of bones." ; obo:SCDO_0000303 "Term should be requested for inclusion into the \"Ontology of Biological Attributes\", perhaps in an appropriate location under \"organ system trait\". Or perhaps below \"bone measurement\" or \"bone marrow measurement\" in the CMO?" ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/intraosseous", "http://www.ncbi.nlm.nih.gov/pubmed/6456552" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "IOP" ; a owl:Class ; rdfs:label "Intraosseous Pressure" ; rdfs:subClassOf obo:SCDO_0000728, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0000710 ] . obo:SCDO_0000660 obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (a genotype or genetic variation) where the entity has a causal role for the condition." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "caused or contributed to by" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_0000661 obo:SCDO_0000303 "Eventually to be replaced by \"is caused by\" object property" ; obo:SCDO_0000929 "metadata incomplete" ; a owl:AnnotationProperty ; rdfs:label "is caused by" . obo:SCDO_0000662 obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and a description of distinctive characteristics or essential features." ; obo:SCDO_0000303 "Requested inclusion of this property into RO. Check details here again after inclusion." ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "is characterised by" . obo:SCDO_0000663 obo:IAO_0000115 "A relation between a phenotype that is a diagnosis and a diagnostic tool used in making the diagnosis." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "diagnosed using tool" . obo:SCDO_0000664 obo:IAO_0000115 "A relation between a condition (phenotype or disease) and a type of treatment or a specific treatment, where the condition can be treated with the treatment." ; obo:SCDO_0000303 "If required later, specify as inverse of \"treats\"." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "treated with" . obo:SCDO_0000665 obo:IAO_0000115 "A hypoperfusion of the blood through an organ or tissue caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation." ; obo:SCDO_0000303 "Should this be under \"Abnormal Cardiovascular System Morphology\" or \"\"Abnormal Cardiovascular System Physiology\"?" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007511" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000665" ; oboInOwl:hasDbXref "MESH:D007511" ; oboInOwl:hasExactSynonym "Ischemias" ; a owl:Class ; rdfs:label "Ischemia" ; rdfs:subClassOf obo:HP_0001626, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000666 obo:IAO_0000115 "Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point." ; obo:SCDO_0000303 "Perhaps change label to \"Hemoglobin Isoeletcric Focusing\"? Exactsynonym \"Hb IEF\". See dc:source provided." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007525" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000666" ; dc:source ; oboInOwl:hasDbXref "MESH:D007525" ; oboInOwl:hasExactSynonym "Electrofocusing", "IEF" ; a owl:Class ; rdfs:label "Isoelectric Focusing" ; rdfs:subClassOf obo:SCDO_0000424, obo:SCDO_1000577 . obo:SCDO_0000676 obo:IAO_0000115 "Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007677" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000676" ; oboInOwl:hasDbXref "MESH:D007677" ; oboInOwl:hasExactSynonym "Kidney Function Tests", "Renal Function Test", "Renal Function Tests" ; a owl:Class ; rdfs:label "Kidney Function Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:SCDO_0000677 obo:IAO_0000115 "A specialized area of medicine in which exercise and movement are used as the primary form of rehabilitation." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/kinesiotherapy" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Kinesiotherapy" ; rdfs:subClassOf obo:SCDO_0000978 . obo:SCDO_0000678 obo:IAO_0000115 "Collections of facts, assumptions, beliefs and practices that health professionals hold about the aetiology, pathophysiology, quality management of SCD and related social support systems based on global standards." ; obo:SCDO_0000303 "Probably too specific to SCD to be included in other ontologies." ; obo:SCDO_0000340 "https://www.ncbi.nlm.nih.gov/mesh/?term=base%2C+knowledge;", "https://www.ncbi.nlm.nih.gov/pubmed/20353928" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Knowledge about Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_0000246 . obo:SCDO_0000682 obo:IAO_0000115 "The level of lactate dehydrogenase, an enzyme released during tissue damage and injury, found in a specified biological specimen." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Should this term's name be changed to \"L-Lactate Dehydrogenase Level\"?""" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "LD Level", "LDH Level", "Lactate Dehydrogenase Levels", "Lactic Acid Dehydrogenase Level" ; a owl:Class ; rdfs:comment "Normal and abnormal ranges given here: https://www.healthline.com/health/lactate-dehydrogenase-test#results" ; rdfs:label "Lactate Dehydrogenase Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000683 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0025435 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000684 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000833 ] . obo:SCDO_0000683 obo:IAO_0000115 "A bioassay to measure levels of lactate dehydrogenase, an enzyme released during tissue damage and injury." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Lactate Dehydrogenase Level\")." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:811001" ; oboInOwl:hasExactSynonym "LDH Test", "Lactate Dehydrogenase Level Test", "Lactic Acid Dehydrogenase Test" ; a owl:Class ; rdfs:label "Lactate Dehydrogenase Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000682 ] . obo:SCDO_0000685 obo:IAO_0000115 "Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (varicose ulcer), 5% to arterial disease, and the remaining 5% to other causes." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007871" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000685" ; oboInOwl:hasDbXref "MESH:D007871" ; oboInOwl:hasExactSynonym "Leg Ulcers" ; a owl:Class ; rdfs:label "Leg Ulcer" ; rdfs:subClassOf obo:HP_0200042, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000689 obo:IAO_0000115 "Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D008019" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000689" ; oboInOwl:hasDbXref "MESH:D008019" ; oboInOwl:hasExactSynonym "Life Style" ; a owl:Class ; rdfs:label "Lifestyle" ; rdfs:subClassOf obo:SCDO_0000487 . obo:SCDO_0000691 obo:IAO_0000115 "The coagulation of tissue by an intense beam of light, including laser (laser coagulation). In the eye it is used in the treatment of retinal detachments, retinal holes, aneurysms, hemorrhages, and malignant and benign neoplasms. (Dictionary of Visual Science, 3d ed)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D008028" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000691" ; oboInOwl:hasDbXref "MESH:D008028" ; oboInOwl:hasExactSynonym "Light Coagulations", "Photocoagulation", "Photocoagulations" ; a owl:Class ; rdfs:label "Light Coagulation" ; rdfs:subClassOf obo:SCDO_0000833 . obo:SCDO_0000694 obo:IAO_0000115 "Any process carried out to determine the condition of a patient's liver." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/IDODEN?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FIDODEN_0003652" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000694" ; oboInOwl:hasDbXref "IDODEN:0003652" ; a owl:Class ; rdfs:label "Liver Examination" ; rdfs:subClassOf obo:SCDO_0000898, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0000698 obo:IAO_0000115 "Personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behaviour versus fate, luck, or external forces." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007389" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000698" ; oboInOwl:hasDbXref "MESH:D007389" ; oboInOwl:hasExactSynonym "Control Locus", "External-Internal Control", "Health Locus of Control", "Internal-External Control", "Sense of Control" ; a owl:Class ; rdfs:label "Locus of Control" ; rdfs:subClassOf obo:SCDO_0000488 . obo:SCDO_0000699 obo:IAO_0000115 "Studies in which variables relating to an individual or group of individuals are assessed over a period of time." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D008137" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000699" ; oboInOwl:hasDbXref "MESH:D008137" ; oboInOwl:hasExactSynonym "Heart Study, Jackson" ; a owl:Class ; rdfs:label "Longitudinal Studies" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000702 obo:IAO_0000115 "A sampling methodology using small sample sizes when conducting surveys in small geographical or population-based areas or lots." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D055810" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000702" ; oboInOwl:hasDbXref "MESH:D055810" ; oboInOwl:hasExactSynonym "LQAS" ; a owl:Class ; rdfs:label "Lot Quality Assurance Sampling" ; rdfs:subClassOf obo:SCDO_0300004 . obo:SCDO_0000704 obo:IAO_0000115 "Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle." ; obo:SCDO_0000303 "Perhaps use the \"DEFINITIONS AND SUBDIVISIONS OF LUNG VOLUME\" section in the \"Lung Function - Lung Volume #810401\" protocol source in PhenX to include types of lung volume as subclasses. Can also use subclasses of Experimental Factor Ontology -- (EFO) term \"pulmonary function measurement or sub-classes of \"Lung Volume Measurements\" in MESH." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D008176" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000704" ; oboInOwl:hasDbXref "MESH:D008176" ; oboInOwl:hasExactSynonym "Lung Capacities", "Lung Capacity", "Lung Volume", "Lung Volume Measurements" ; a owl:Class ; rdfs:label "Lung Volume Measurement" ; rdfs:subClassOf obo:CMO_0000094, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:NCIT_C85397 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000705 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0001099 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000705 obo:IAO_0000115 "Clinical assessment to determine the volume of gas within an individual's lung." ; obo:SCDO_0000303 """Suggest update to label in PhenX (from \"Lung Function - Lung Volume\") Perhaps use the protocol source in PhenX to include different ways of measuring FRC (functional residual capacity) as subclasses (e.g. Measurement of FRC using body plethysmography, Measurement of FRC using nitrogen washout, Measurement of FRC using helium dilution, Measurement of lung volume using imaging techniques). SNOMED has more terms below \"Lung Volume Test\" Link to necessary medical device.""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Protocol - Lung Function - Lung Volume #810401" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:810401" ; oboInOwl:hasExactSynonym "Lung Function - Lung Volume", "Lung Volume Assay", "Pulmonary Volume Assay", "Pulmonary Volume Test" ; a owl:Class ; rdfs:label "Lung Volume Test" ; rdfs:subClassOf obo:SCDO_0000942, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0001099 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000704 ] . obo:SCDO_0000706 obo:IAO_0000115 "'The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/UBERON_0002465" ; oboInOwl:hasDbXref "UBERON:0002465" ; a owl:Class ; rdfs:label "obsolete Lymphoid System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000709 obo:IAO_0000115 "The use of drugs or other agents to prevent malarial infection. Examples: Proguanil, mefloquine, artesunate, insect repellant, insecticide-treated-bednet." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.cdc.gov/malaria/travelers/drugs.html" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Malaria Prevention" ; a owl:Class ; rdfs:label "Malaria Prophylaxis" ; rdfs:subClassOf obo:SCDO_0000930, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002725 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:SCDO_0000710 obo:IAO_0000115 "An instrument that is used for measuring the pressure of liquids and gases." ; obo:SCDO_0000303 """Request inclusion into \"Eagle-I Research Resource Ontology\", below the \"instrument\" term. Perhaps the specific manometer used for measuring \"Intraosseous Pressure\" should be added as a sub-class and linked to directly.""" ; obo:SCDO_0000340 "The American Heritage Science Dictionary. Retrieved October 20, 2016 from Dictionary.com website", "http://www.dictionary.com/browse/manometer" ; obo:SCDO_1000288 "Negligable" ; a owl:Class ; rdfs:label "Manometer" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000474 ; owl:someValuesFrom obo:SCDO_0000657 ] . obo:SCDO_0000711 obo:IAO_0000115 "The current marital status of the respondent's caregiver (i.e. family member or another individual who takes primary responsibility for the respondent)." ; obo:SCDO_0000303 "Request inclusion into MESH below \"Family Characteristics\"." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Marital Status of Primary Caregiver #840101" ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasDbXref "phenX:840101" ; a owl:Class ; rdfs:label "Marital Status of Primary Caregiver" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_0001090, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000725 obo:IAO_0000115 "A questionnaire to capture the frequency of acute pain episodes within a defined time frame due to sickle cell disease (SCD). It includes three self-administered questions from the Cooperative Study of Sickle Cell Disease (CSSCD) that capture number of painful episodes that required visits to the emergency room or hospital or interfered with daily activities." ; obo:SCDO_0000303 "Suggest update to label in PhenX as we have done here because we have used \"Frequency of Sickle Cell Pain Episodes Per Year\" for the Diagnostic Instrument Measurement." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Frequency of Sickle Cell Pain Episodes Per Year #830101" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:830100" ; a owl:Class ; rdfs:label "Measure of Frequency of Sickle Cell Pain Episodes" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_0000953, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000726 obo:IAO_0000115 "Measure of disease specific stigma based on patient reported outcome measurements that assesses 4 MoSCS factors: Social exclusion, Internalized Stigma, Expected Discrimination and Disclosure concerns. Measure includes stigma scores; perceived disease severity, acute care service utilization, hospital admission levels. N=262." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "J Health Psychol. 2016 May; 21(5): 808–820." ; obo:SCDO_0000470 "African-Americans" ; obo:SCDO_0000481 "Patient Reported Outcome" ; obo:SCDO_0000482 "Adults with Sickle Cell Disease" ; obo:SCDO_0001222 "Adults 18 years and older" ; obo:SCDO_1000288 "None" ; dc:source "Bediako, Shawn M et al. “The Measure of Sickle Cell Stigma: Initial Findings from the Improving Patient Outcomes through Respect and Trust Study.” Journal of health psychology (2014): 1359105314539530. PMC. Web. 13 Mar. 2016. PMCID: PMC4627860" ; oboInOwl:hasExactSynonym "Measure of Sickle Cell Stigma", "MoSCS" ; a owl:Class ; rdfs:label "Measure of Sickle Cell Stigma (MoSCS)" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0000727 obo:IAO_0000115 "The weight of the participant in kilograms." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Measured Weight" ; rdfs:subClassOf obo:SCDO_0000152 . obo:SCDO_0000728 obo:IAO_0000115 "An information entity used in the diagnosis of medical conditions. It could be the recording of the output of a diagnostic device or the outcome of a diagnostic tool." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Diagnostic Quantitative Measurement" ; a owl:Class ; rdfs:label "Diagnostic Measurement" ; rdfs:subClassOf obo:SCDO_0000379 . obo:SCDO_0000737 obo:IAO_0000115 "The MOS Social Support Survey is a self-administered questionnaire that includes 19 items across four functional support subscales: emotional/informational support (8 items), tangible/instrumental support (4 items), affectionate support (3 items), and positive social interaction (3 items). Each item is scored on a 5-point Likert style scale (1 = None of the Time; 5 = All of the Time) to indicate how often that type of support is available to them. A score for each social support subscale can be computed by averaging across the individual items or by adding scores individual items together. Higher scores indicate more support." ; obo:SCDO_0000303 "Check and show which source was used for the description and whether the description was adapted from the source.", "Suggest update to description in NCIT for \"Medical Outcomes Study Social Support Survey\"." ; obo:SCDO_0000340 "Sherbourne CD, Stewart A. The MOS Social Support Survey. Social Science and Medicine, v. 32, 1991, pp. 705-714.", "Sherbourne, Cathy D. and Anita Stewart. The MOS Social Support Survey. Santa Monica, CA: RAND Corporation, 1993." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic patients" ; obo:SCDO_0001222 "Adults 18 years and older" ; obo:SCDO_0001335 "no" ; obo:SCDO_1000288 "Suggest update to description" ; dc:source , ; oboInOwl:hasDbXref "NCIT:C110969" ; oboInOwl:hasExactSynonym "MOS Social Support Survey", "Medical Outcomes Study Social Support Survey" ; a owl:Class ; rdfs:label "Medical Outcomes Study (MOS) Social Support Survey" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0000738 obo:IAO_0000115 "Recording of pertinent information concerning patient's illness or illnesses." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D008499" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000738" ; oboInOwl:hasDbXref "MESH:D008499" ; a owl:Class ; rdfs:label "Medical Records" ; rdfs:subClassOf obo:SCDO_0000948 . obo:SCDO_0000739 obo:IAO_0000115 "Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D055118" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000739" ; oboInOwl:hasDbXref "MESH:D055118" ; a owl:Class ; rdfs:label "Medication Adherence" ; rdfs:subClassOf obo:SCDO_0000869 . obo:SCDO_0000740 obo:IAO_0000115 "A record of the type and dosage of all prescription and over-the-counter medications as well as dietary supplements currently being taken by the individual." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Would it also be appropriate to add this to \"Diagnostic Instrument\" below \"Diagnostics\"?""" ; obo:SCDO_0000479 "PhenX protocol: Medication Inventory #140301" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Medication Inventory" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_1000157, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000741 obo:IAO_0000115 "A state of consciousness in which the individual eliminates environmental stimuli from awareness so that the mind can focus on a single thing, producing a state of relaxation and relief from stress. A wide variety of techniques are used to clear the mind of stressful outside interferences. It includes meditation therapy. (Mosby's Medical, Nursing, and Allied Health Dictionary, 4th ed)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D019122" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000741" ; oboInOwl:hasDbXref "MESH:D019122" ; oboInOwl:hasExactSynonym "Transcendental Meditation" ; a owl:Class ; rdfs:label "Meditation" ; rdfs:subClassOf obo:SCDO_0001284 . obo:SCDO_0000742 obo:IAO_0000115 "A phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000742" ; oboInOwl:hasDbXref "MESH:D015767" ; oboInOwl:hasExactSynonym "Lariam", "Mephloquine", "WR142,490" ; a owl:Class ; rdfs:label "Mefloquine" ; rdfs:subClassOf obo:IDOMAL_0000122, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:SCDO_0000743 obo:IAO_0000115 "A type of glomerulonephropathy characterized by histology with thickening of the basement membrane and deposition of immune complexes in the subepithelial space." ; obo:SCDO_0000303 "Suggest update to description in HPO" ; obo:SCDO_0000340 obo:HP_0012578 ; obo:SCDO_0000468 "Typically seen in adult population; rare in children." ; obo:SCDO_0000661 "Idiopathic - may be related to M-type phosplipase A2 receptor antibodies; secondary forms may be related to autoimmune disease, underlying maligancies, drugs or infections. Has been reported in patients with sickle cell disease." ; obo:SCDO_0000662 "Nephrotic syndrome with histologic features specific to membranous nephropathy." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0012578" ; oboInOwl:hasExactSynonym "MN", "Membranous Glomerulopathy" ; a owl:Class ; rdfs:label "Membranous Nephropathy" ; rdfs:subClassOf obo:HP_0000112, obo:HP_0002715, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:SCDO_0000746 obo:IAO_0000115 "Emotional, psychological, and social well-being of an individual or group." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000746" ; oboInOwl:hasDbXref "MESH:D008603" ; oboInOwl:hasExactSynonym "Emotional Health", "Mental Hygiene" ; a owl:Class ; rdfs:label "Mental Health" ; rdfs:subClassOf obo:NCIT_C17047, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C17047 ] . obo:SCDO_0000747 obo:IAO_0000115 "Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017418" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000747" ; oboInOwl:hasDbXref "MESH:D017418" ; a owl:Class ; rdfs:label "Meta-Analysis" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0000748 obo:IAO_0000115 "The state of the chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (anabolism) and the breakdown (catabolism) of organic materials utilized by the living organism." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Add as sub-classes: Metabolic Function Normal and Metabolic Function Abnormal? (from SNOMED CT)""" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D008660" ; obo:SCDO_1000288 "None" ; oboInOwl:hasDbXref "MESH:D008660" ; oboInOwl:hasExactSynonym "Metabolic Function" ; a owl:Class ; rdfs:label "Metabolic State" ; rdfs:subClassOf obo:SCDO_0000122 . obo:SCDO_0000753 obo:IAO_0000115 "The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D008708" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000753" ; oboInOwl:hasDbXref "MESH:D008708" ; oboInOwl:hasExactSynonym "MetHb" ; a owl:Class ; rdfs:label "Methemoglobinemia" ; rdfs:subClassOf obo:OGMS_0000047 . obo:SCDO_0000754 obo:IAO_0000115 "'Any procedure or test to diagnose a disease or disorder. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0000082 ; obo:SCDO_0000303 "Perhaps move other sibling classes below this class? (Imaging Test/Diagnostic Imaging, -- -- Include sub-class \"Biopsy\" and include specific types below that?" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C18020" ; oboInOwl:hasDbXref "NCIT:C18020" ; oboInOwl:hasExactSynonym "Diagnostic Procedure" ; a owl:Class ; rdfs:label "deprecated Diagnostic Method" ; rdfs:subClassOf obo:SCDO_1000034 ; owl:deprecated true . obo:SCDO_0000760 obo:IAO_0000115 "A questionnaire to assess migraines and headaches." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Migraine\") as we have done." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:130500" ; oboInOwl:hasExactSynonym "Headache Disability Questionnaire" ; a owl:Class ; rdfs:label "Migraine Questionnaire" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033 . obo:SCDO_0000762 obo:IAO_0000115 "Transportable radiographic equipment allowing imaging services to be brought to the patient." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.who.int/medical_devices/innovation/hospt_equip_26.pdf", "https://radiologykey.com/mobile-radiography/" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Mobile Radiographic Unit" ; rdfs:subClassOf obo:OBI_0001138 . obo:SCDO_0000763 obo:IAO_0000115 "Difficulty moving from place to place or from one position to another without assistance." ; obo:SCDO_0000303 "Suggest update to description in MESH." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D051346" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D051346" ; oboInOwl:hasExactSynonym "Ambulation Difficulty", "Ambulatory Difficulty", "Difficulty Ambulation", "Difficulty Walking", "Mobility Limitations" ; a owl:Class ; rdfs:label "Mobility Limitation" ; rdfs:subClassOf obo:SCDO_0000900 . obo:SCDO_0000765 obo:IAO_0000115 "The biological processes, properties, and objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000765" ; oboInOwl:hasDbXref "MESH:D055614" ; oboInOwl:hasExactSynonym "Concepts, Genetic" ; a owl:Class ; rdfs:label "Genetic Phenomena" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_0000766 obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/ADO/?p=classes&conceptid=http%3A%2F%2Fscai.fraunhofer.de%2FAlzheimerOntology%23Modifying_the_home_enviornment_and_make_it_safer_for_the_patient" ; a owl:Class ; rdfs:label "obsolete Modifying the Home Environment and Making it Safer For the Patient" ; rdfs:subClassOf obo:SCDO_1000035 ; owl:deprecated true . obo:SCDO_0000771 obo:IAO_0000115 "The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000771" ; oboInOwl:hasDbXref "MESH:D009020" ; oboInOwl:hasExactSynonym "17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-17-ium-3,6alpha-diol", "Morphia", "Morphium" ; a owl:Class ; rdfs:label "Morphine" ; rdfs:subClassOf obo:CHEBI_35482, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000772 obo:IAO_0000115 "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the mortality (due to the phenotype) of the SCD sufferer." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "mortality modified by" ; rdfs:subPropertyOf obo:SCDO_1000005 . obo:SCDO_0000774 obo:IAO_0000115 "'A work that reports on a study executed by several cooperating institutions. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016448" ; oboInOwl:hasDbXref "MESH:D016448" ; a owl:Class ; rdfs:label "obsolete Multicenter Study" ; rdfs:subClassOf obo:SCDO_0000941 ; owl:deprecated true . obo:SCDO_0000775 obo:IAO_0000115 "Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000775" ; oboInOwl:hasDbXref "MESH:D015337" ; oboInOwl:hasExactSynonym "Multicenter Trial", "Multicenter Trials", "Multicentre Studies as Topic", "Multicentre Trial", "Multicentre Trials" ; a owl:Class ; rdfs:label "Multicenter Studies as Topic" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_0000776 obo:IAO_0000115 "The multidimensional health locus of control (MHLC) scale is a widely used measure of the factors that people believe exert some measures of control over their health. The MHLC originally developed by Wallston and colleagues contained 3 subscales describing various types of control-related cognitions an individual may have about the current state of his or her health. These were: Internal Health Locus of Control (IHLC), Powerful Others Health Locus of Control (PHLC) and Chance Health Locus of Control (CHLC). Subsequently, a fourth subscale, the God Locus of Health Control (G LHC) scale was developed to assess the extent of an individual's belief that God controls his or her health status was added to the measure. Thus, the expanded MHLC Consists of 4 sub-scales: one Internal and 3 external subscales namely, powerful others, chance and God. Each of the 4 sub-scales has 6 items making a total of 24 items. The two original versions of the MHLC (forms A & B) deal with the general health status whereas the third version (Form C) assesses control-related cognitions about a specific disease state." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Healthy population and patients with specific medical conditions" ; obo:SCDO_0000484 "Spanish; Chinese; Persian" ; obo:SCDO_0001033 "Has adequate construct validity and acceptable metric properties" ; obo:SCDO_0001222 "15 years and above" ; obo:SCDO_0001335 "no" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "Wallston K., Wallston B. and De Vellis R. (1978). Development of the multidimensional health locus of control (MHLC) scales. Health Education Monographs, 6, 160-169.", "Wallston KA, Malcarne VL, Flores L, Hansdottir I, Smith CA, Stein MJ, Weisman MH, Clements PJ. Does God Determine Your Health? The God Locus of Health Control Scale. Cognitive Therapy and Research . April 1999, Volume 23 (2):131-142." ; oboInOwl:hasExactSynonym "MHLC", "MHLC Scales", "Multidimensional Health Locus of Control Scales" ; a owl:Class ; rdfs:label "Multidimensional Health Locus of Control Scales (MHLC)" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0000777 obo:IAO_0000115 "The presence of skeletal muscular atrophy, reduction in the muscle bulk." ; obo:SCDO_0000303 """Suggest update to description in HPO. Provide source for additional info.""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0003202" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0003202" ; oboInOwl:hasExactSynonym "Amyotrophy", "Muscle Wasting", "Muscular Atrophy", "Neurogenic Muscle Atrophy", "Skeletal Muscle Atrophy" ; a owl:Class ; rdfs:label "Muscle Atrophy" ; rdfs:subClassOf obo:SCDO_1000268 . obo:SCDO_0000780 obo:IAO_0000115 "Anatomical system that consists of the muscular and skeletal systems." ; obo:IAO_0100001 obo:SCDO_0006301, obo:SCDO_1000268 ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/UBERON_0002204" ; oboInOwl:hasDbXref "UBERON:0002204" ; oboInOwl:hasExactSynonym "Musculo-Skeletal System" ; a owl:Class ; rdfs:label "deprecated Musculoskeletal System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000781 obo:IAO_0000115 "The process of identifying carriers/heterozygotes of a genetic mutation that can result in a severe recessive condition. Carrier screening is done using various laboratory techniques." ; obo:SCDO_0000303 "Request inclusion into relevant ontology (MESH) or suggest inclusion of description in NCIT." ; obo:SCDO_0000340 "Alswaidi, F.M. and O'brien, S.J., 2009. Premarital screening programmes for haemoglobinopathies, HIV and hepatitis viruses: review and factors affecting their success. Journal of medical screening, 16(1), pp.22-28." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasDbXref "MESH:D006580" ; oboInOwl:hasExactSynonym "Mutation Carrier Detection" ; a owl:Class ; rdfs:comment "This term is very similar to but different (more specific) from the term \"Genetic Carrier Screening\" in MESH." ; rdfs:label "Mutation Carrier Screening" ; rdfs:subClassOf obo:NCIT_C92803 . obo:SCDO_0000782 obo:IAO_0000115 "This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants." ; obo:SCDO_0000303 "Exists in other ontologies but we have provided a description more relevant to its relationship with SCD.", "Link to \"Hereditary Persistence of fetal hemoglobin\"." ; obo:SCDO_0000340 "http://www.ncbi.nlm.nih.gov/gene/4602" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; oboInOwl:hasExactSynonym "MYB Gene", "MYB Proto-Oncogene, Transcription Factor", "MYB-HSP1" ; a owl:Class ; rdfs:label "MYB" ; rdfs:subClassOf obo:SCDO_0000810 . obo:SCDO_0000787 obo:IAO_0000115 "A bioassay to determine an individual's level of N-terminal pro-brain natriuretic peptide (NT-proBNP)." ; obo:SCDO_0000303 "Label different from source's \"N-terminal Pro-brain Natriuretic Peptide (NT-proBNP)\"" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:810501" ; oboInOwl:hasExactSynonym "NT-proBNP Test" ; a owl:Class ; rdfs:comment "Equipment needed: Phlebotomy supplies, centrifuge for serum separation, and freezer for sample storage is required." ; rdfs:label "N-terminal Pro-brain Natriuretic Peptide Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:CMO_0002876 ] . obo:SCDO_0000789 obo:IAO_0000115 "A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors." ; obo:SCDO_0000303 "Are the synonyms included relevant to SCD? Should other synonyms from the description source be included?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000789" ; oboInOwl:hasDbXref "MESH:D009270" ; oboInOwl:hasExactSynonym "1-N-Allyl-14-hydroxynordihydromorphinone", "17-allyl-3,14-dihydroxy-4,5α-epoxymorphinan-6-one", "MRZ-2593" ; a owl:Class ; rdfs:label "Naloxone" ; rdfs:subClassOf obo:CHEBI_35482, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0000791 obo:IAO_0000115 "Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000791" ; oboInOwl:hasDbXref "MESH:D014663" ; oboInOwl:hasExactSynonym "Nasal Vasoconstrictor Agents", "Nasal Vasoconstrictors" ; a owl:Class ; rdfs:label "Nasal Decongestants" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001129 . obo:SCDO_0000794 obo:IAO_0000115 "'A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D009398" ; oboInOwl:hasDbXref "MESH:D009398" ; a owl:Class ; rdfs:label "obsolete Nephrology" ; rdfs:subClassOf obo:SCDO_0001208 ; owl:deprecated true . obo:SCDO_0000796 obo:IAO_0000115 "Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria >3.5 g per 24 hours (in children, >40 mg/m2/hr or PCR >2000 mg/g [>200 mg/mmol] or >300 mg/dl or 3+ on urine dipstick) plus hypoalbuminemia (<3gm/dl) and edema." ; obo:SCDO_0000303 "Suggest update to description in the HPO" ; obo:SCDO_0000340 obo:HP_0000100 ; obo:SCDO_0000468 "Nephrotic syndrome related to sickle cell disease typically occurs in adulthood and preceded by lesser degree of proteinuria, other forms may occur at any age with different histologic lesions occurring at different ages." ; obo:SCDO_0000661 "Variety of causes - in sickle cell disease, most common lesion is focal segmental glomerulosclerosis (FSGS). Other causes may be other forms of primary glomerular disease including membranous nephropathy, minimmal change disease, membranoproliferative glomerulonephritis. Secondary forms may result from diabetes, amyloidosis." ; obo:SCDO_0000662 "Heavy proteinuria, edema, hyperlipidemia. May also be associated with hypertension and increased risk of venous thrombosis." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0000100" ; oboInOwl:hasExactSynonym "Nephrosis" ; a owl:Class ; rdfs:label "Nephrotic Syndrome" ; rdfs:subClassOf obo:HP_0000112, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001205 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001206 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000055 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001207 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001210 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001212 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000797 obo:IAO_0000115 "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children." ; obo:SCDO_0000303 "Suggest update to description in HPO." ; obo:SCDO_0000340 obo:HP_0012593, ; obo:SCDO_0000468 "In sickle cell disease, seen primarily in adult population but may develop in childhood if secondary cause occurs." ; obo:SCDO_0000661 "Glomerular diseases that lead to protein loss in the urine (See Nephrotic Syndrome)." ; obo:SCDO_0000662 "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children." ; obo:SCDO_1000288 "Suggest update to description" ; dc:source obo:HP_0012593, ; oboInOwl:hasDbXref "HP:0012593" ; oboInOwl:hasExactSynonym "Nephrotic-Range Proteinuria" ; a owl:Class ; rdfs:comment "Is diagnosed by assessment of proteinuria (see Proteinuria) by 24hr urine collection or by urine protein-creatinine ratio on spot urine sample [KDIGO 2012]." ; rdfs:label "Nephrotic Range Proteinuria" ; rdfs:subClassOf obo:SCDO_0000932, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001205 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001206 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000055 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001207 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001210 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001212 ] . obo:SCDO_0000798 obo:IAO_0000115 "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior." ; obo:IAO_0100001 obo:SCDO_0009698 ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/UBERON_0001016" ; oboInOwl:hasDbXref "UBERON:0001016" ; oboInOwl:hasExactSynonym "Neurological System" ; a owl:Class ; rdfs:label "deprecated Nervous System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000799 obo:IAO_0000115 "An invisible complication of sickle cell anemia (SSA) that defies detection by imaging and other routine diagnostic methods. Impaired neurocognitive function in seemingly neurologically intact patients is not related to vasoocclusion or hemolysis. It is detected by neuropsychiatric and neurobehavioral testing and is associated with anemia and age." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415156/" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Neurocognitive Impairment" ; rdfs:subClassOf obo:HP_0012638, obo:SCDO_0000895 . obo:SCDO_0000801 obo:IAO_0000115 "Physician-supervised programs designed to rehabilitate people with diseases, trauma, or disorders of the nervous system." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000066530" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000801" ; oboInOwl:hasDbXref "MESH:D000066530" ; oboInOwl:hasExactSynonym "Neurologic Rehabilitation", "Neurorehabilitation", "Rehabilitation, Neurologic", "Rehabilitation, Neurological" ; a owl:Class ; rdfs:label "Neurological Rehabilitation" ; rdfs:subClassOf obo:SCDO_0000978 . obo:SCDO_0000803 obo:IAO_0000115 "Testing of neonates to identify those with major sickling diseases." ; obo:SCDO_0000303 """Link to \"Hb isoelectric focusing\" and \"HPLC fractionation\" ? Request inclusion into relevant ontology. Perhaps in SNOMED CT below \"Screening for sickle cell disease\"?""" ; obo:SCDO_0000340 "Newborn Screening for Sickle Cell Disease and Other Hemoglobinopathies. JAMA. 1987;258(9):1205–1209. doi:10.1001/jama.1987.03400090089040" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Newborn Infant Screening for Sickle Cell" ; a owl:Class ; rdfs:label "Neonatal Screening for Sickle Cell" ; rdfs:subClassOf obo:SCDO_0001049 . obo:SCDO_0000804 obo:IAO_0000115 "A physical assessment of the various symptoms associated with a stroke, consisting of 11 categories. For each category, the test administrator asks the respondent to perform an activity or respond to stimuli. Respondents receive a score for each category based upon their ability to complete the activity or respond to the action. Each score typically ranges from 0 to 3. Each category of the NIHSS is designed to determine the respondent's level of consciousness (LOC), visual, motor, or language ability." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820801" ; obo:SCDO_0000479 "PhenX protocol: NIH Stroke Scale (NIHSS) #820801" ; obo:SCDO_0001222 "18 years and older" ; obo:SCDO_0001335 "Examiners must be trained to administer, score, and interpret the NIH Stroke Scale (NIHSS). The National Institute of Neurological Disorders and Stroke (NINDS) provides a comprehensive interactive training DVD for the NIHSS. Information and purchasing details for this training are available on the NINDS website." ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasDbXref "phenX:820801" ; oboInOwl:hasExactSynonym "NIH Stroke Scale", "NIHSS" ; a owl:Class ; rdfs:label "NIH Stroke Scale (NIHSS)" ; rdfs:subClassOf obo:SCDO_0001112, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000807 obo:IAO_0000115 "Patients who do not turn up for scheduled healthcare appointments." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000067455" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000807" ; oboInOwl:hasDbXref "MESH:D000067455" ; oboInOwl:hasExactSynonym "No Show Patient", "Patient No Show", "Patient No-Show" ; a owl:Class ; rdfs:label "No-Show Patient" ; rdfs:subClassOf obo:SCDO_0000869 . obo:SCDO_0000808 obo:IAO_0000115 "Frequent urination at night that interrupts sleep. It is often associated with outflow obstruction, diabetes mellitus, or bladder inflammation (cystitis)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D053158" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000808" ; oboInOwl:hasDbXref "MESH:D053158" ; oboInOwl:hasExactSynonym "Nycturia" ; a owl:Class ; rdfs:comment "Often occuring as a result of heart insufficiency." ; rdfs:label "Nocturia" ; rdfs:subClassOf obo:HP_0000079, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:SCDO_0000809 obo:IAO_0000115 "A subclass of analgesic agents that typically do not bind to opioid receptors and are not addictive. Many non-narcotic analgesics are offered as nonprescription drugs." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018712" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000809" ; oboInOwl:hasDbXref "MESH:D018712" ; oboInOwl:hasExactSynonym "Non-Narcotic", "Nonnarcotic", "Nonnarcotic Analgesic", "Nonnarcotic Opioid", "Nonopioid" ; a owl:Class ; rdfs:label "Non Opioid" ; rdfs:subClassOf obo:SCDO_0000050, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000810 obo:IAO_0000115 "A gene that does not encode a globin family protein." ; obo:SCDO_0000303 "Perhaps too specific to the SCDO to be included in other ontologies?" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Non-Globin Gene" ; rdfs:subClassOf obo:NCIT_C16612 . obo:SCDO_0000811 obo:IAO_0000115 "Sickle retinopathy caused by direct damage or remodeling of the small blood vessels supplying the retina secondary to vaso-occlusion and local ischemia." ; obo:SCDO_0000303 "Request inclusion into HPO below \"Retinopathy/Sickle Retinopathy\"." ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Retinopathy", "http://eyewiki.aao.org/Sickle_Cell_Retinopathy" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Non-Proliferative Sickle Retinopathy" ; rdfs:subClassOf obo:SCDO_0001067, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000812 obo:IAO_0000115 "Includes acute respiratory episodes with lower respiratory tract signs that do not meet the criteria for other diagnoses. May include episodes which would have been diagnosed as ACS were radiographic facilities available." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Provide source for additional info.""" ; obo:SCDO_0000661 "Several possible etiologies including infections by various classes of microorganisms, pulmonary fat emobolism, infarction and pulmonary embolism." ; obo:SCDO_0000662 "Acute onset of respiratory symptoms and signs including cough, coryza +/- fever." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Non-specific Acute Lower Respiratory Tract Episode" ; rdfs:subClassOf obo:HP_0002086, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000576 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000903 ] . obo:SCDO_0000818 obo:IAO_0000115 "'A work that reports on the results of a clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study). [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D064888" ; oboInOwl:hasDbXref "MESH:D064888" ; a owl:Class ; rdfs:label "obsolete Observational Study" ; rdfs:subClassOf obo:SCDO_0000252 ; owl:deprecated true . obo:SCDO_0000819 obo:IAO_0000115 "Works about clinical studies in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D064887" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000819" ; oboInOwl:hasDbXref "MESH:D064887" ; a owl:Class ; rdfs:label "Observational Studies as Topic" ; rdfs:subClassOf obo:SCDO_0000253 . obo:SCDO_0000822 obo:IAO_0000115 "Skilled treatment that helps individuals achieve independence in all facets of their lives. It assists in the development of skills needed for independent living." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D009788" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000822" ; oboInOwl:hasDbXref "MESH:D009788" ; oboInOwl:hasExactSynonym "Occupational Therapies", "Therapies, Occupational", "Therapy, Occupational" ; a owl:Class ; rdfs:label "Occupational Therapy" ; rdfs:subClassOf obo:SCDO_0000978, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1188 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001271 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001342 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001370 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0010628 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C26702 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000828 obo:IAO_0000115 "Low output of urine, defined as an output below 5mL/kg/hr over 6 hours." ; obo:SCDO_0000303 "Suggest update to description in HPO" ; obo:SCDO_0000340 obo:HP_0100520 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0100520" ; oboInOwl:hasExactSynonym "Reduced Urine Output" ; a owl:Class ; rdfs:label "Oliguria" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000256 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000833 obo:IAO_0000115 "Surgery performed on the eye or any of its parts." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D013508" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000833" ; oboInOwl:hasDbXref "MESH:D013508" ; oboInOwl:hasExactSynonym "Ophthalmologic Surgical Procedures", "Ophthalmological Surgical Procedure" ; a owl:Class ; rdfs:label "Ophthalmologic Surgical Procedure" ; rdfs:subClassOf obo:SCDO_0001133 . obo:SCDO_0000834 obo:IAO_0000115 "Device for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D019721" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000834" ; oboInOwl:hasDbXref "MESH:D019721" ; oboInOwl:hasExactSynonym "Funduscope", "Ophthalmoscopes" ; a owl:Class ; rdfs:label "Ophthalmoscope" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:NCIT_C101217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000835 ] . obo:SCDO_0000835 obo:IAO_0000115 "Examination of the interior of the eye with an ophthalmoscope." ; obo:SCDO_0000303 "Include \"Direct Ophthalmoscopy\" and \"Indirect Ophthalmoscopy\" from NCIT as sub-classes? (Direct could be used to diagnose \"Conjunctival Comma Sign\")" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D009887" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000835" ; oboInOwl:hasDbXref "MESH:D009887" ; a owl:Class ; rdfs:label "Ophthalmoscopy" ; rdfs:subClassOf obo:NCIT_C38060, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0000834 ] . obo:SCDO_0000839 obo:IAO_0000115 "A general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets." ; obo:SCDO_0000303 """Suggest update to description in HPO. (remove \"Osteomalacia\" from start of definitiion) Provide source for additional info.""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002749" ; obo:SCDO_0000661 "Abnormal vitamin D metabolism: 1) Deficient intake or absorption;2) Defective 25-hydroxylation due to biliary cirrhosis- alcoholic cirrhosis- anticonvulsants; 3) Loss of vitamin D binding protein- nephrotic syndrome; 4) Defective 1-alpha 25-hydroxylation: Hypoparathyroidism, Renal failure, Vitamin D-dependent rickets type 1; 5) Defective target organ response to calcitriol: Vitamin D-dependent rickets, type II (Hereditary vitamin D resistant rickets, HVDRR). Mineralization defects: 1) Abnormal matrix: Chronic renal failure, Osteogenesis imperfecta, Fibrogenesis imperfecta, Axial osteomalacia; 2) Enzyme deficiency: Hypophosphatasia; 3) Mineralization inhibitors: bisphosphonates, Aluminum, fluoride. Phosphate deficiency: 1) Decreased intake ( antiacids); 2) Impaired renal reabsorption, that can be Primary defects = X-linked hypophosphatemic rickets (vitamin D resistant rickets, VDRR), Hereditary hypophosphatemic rickets with hypercalciuria, Sporadic acquired hypophosphatemic rickets, Fanconi syndrome, Wilson disease, cystinosis, multiple myeloma; or can be Secondary defects = 2) Secondary hyperparathyroidism (renal tubular acidosis, type 1 and disorders of vitamin D metabolism), 2) Oncogenic osteomalacia." ; obo:SCDO_0000662 "May be asymptomatic and present radiologically as osteopenia. Or it may present as diffuse bone and joint pain, muscle weakness, and difficulty walking, Fractures, Muscle spasms, cramps." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0002749" ; oboInOwl:hasExactSynonym "Adult Rickets" ; a owl:Class ; rdfs:label "Osteomalacia" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000840 obo:IAO_0000115 "An inflammatory process accompanied by bone destruction and caused by an infecting microorganism." ; obo:SCDO_0000303 """Suggest update to description in HPO (remove \"Osteomyelitis is\" from the start of the definition. Provide source for additional info.""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0002754" ; obo:SCDO_0000661 "Bacteria, blunt trauma, fracture, bone surgery." ; obo:SCDO_0000662 "Tenderness, redness, and warmth in the area of infection, fever, fatigue, bone pain, swelling around the affected bone, lost range of motion." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0002754" ; oboInOwl:hasExactSynonym "Bone Infection" ; a owl:Class ; rdfs:comment "Osteomyelitis can be acute or chronic and can be caused by a variety of microbial agents." ; rdfs:label "Osteomyelitis" ; rdfs:subClassOf obo:HP_0000924, obo:IDO_0000586, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000849 obo:IAO_0000115 "The amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity, as determined by an arterial blood gas test." ; obo:SCDO_0000303 "Request inclusion into CMO below \"Oxygen Saturation\"" ; obo:SCDO_0000340 obo:CMO_0001324 ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Arterial HbO2", "Arterial Oxyhemoglobin Saturation", "Arterial SaO2", "Arterial Sats", "HBOXHGB", "Oxygen Saturation of Arterial Blood", "Oxyhemoglobin to Total Hemoglobin Ratio Measurement", "Oxyhemoglobin/Total Hemoglobin" ; a owl:Class ; rdfs:label "Arterial Oxygen Saturation" ; rdfs:subClassOf obo:CMO_0000225, obo:CMO_0001324, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000808 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000813 ] . obo:SCDO_0000851 obo:IAO_0000115 "An unpleasant sensory and emotional experience triggered in the nervous system, associated with actual or potential tissue damage, or described in terms of such damage." ; obo:SCDO_0000303 """Suggest update to description in HPO. Provide source for additional info.""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0012531" ; obo:SCDO_0000661 "Somatic pain is caused by injury to skin, muscles, bone, joint, and connective tissues. Deep somatic pain is usually described as dull or aching, and localized in one area. Visceral pain refers to pain that originates from ongoing injury to the internal organs or the tissues that support them. Somatic pain from injury to the skin or the tissues just below it often is sharper and may have a burning or pricking quality." ; obo:SCDO_0000662 "Nociceptive pain is believed to be caused by the ongoing activation of pain receptors in either the surface or deep tissues of the body. There are two types: \"somatic\" pain and \"visceral\" pain. Neuropathic pain is believed to be caused by changes in the nervous system that sustain pain even after an injury heals. \"Psychogenic\" pain is a simple label for all kinds of pain that can be best explained by psychological problems." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0012531" ; a owl:Class ; rdfs:label "Pain" ; rdfs:subClassOf obo:HP_0025142, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001167 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000852 obo:IAO_0000115 "The impact of sickle cell pain on the daily activities of patients. The degree to which pain interferes with their quality of life. This pain is related to the unique features of Sickle Cell Disease." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Pain Burden", "Pain Disability", "Pain Impact", "Pain Interference" ; a owl:Class ; rdfs:label "Pain Status" ; rdfs:subClassOf obo:SCDO_0000900 . obo:SCDO_0000864 obo:IAO_0000115 "A method of determining the shape and consistency of the liver by feeling with the fingers or hands." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Liver Palpation" ; a owl:Class ; rdfs:label "Palpation of Liver" ; rdfs:subClassOf obo:SCDO_0000694 . obo:SCDO_0000866 obo:IAO_0000115 "Invertebrate organisms that live on or in another organism (the host), and benefit at the expense of the other. Traditionally excluded from definition of parasites are pathogenic bacteria; fungi; viruses; and plants; though they may live parasitically." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D010271" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000866" ; oboInOwl:hasDbXref "MESH:D010271" ; oboInOwl:hasExactSynonym "Parasites" ; a owl:Class ; rdfs:label "Parasite" ; rdfs:subClassOf obo:OBI_0000925 . obo:SCDO_0000869 obo:IAO_0000115 "Voluntary cooperation of the patient in following a prescribed regimen." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D010349" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000869" ; oboInOwl:hasDbXref "MESH:D010349" ; oboInOwl:hasExactSynonym "Adherence", "Patient Adherence", "Patient Cooperation" ; a owl:Class ; rdfs:label "Patient Compliance" ; rdfs:subClassOf obo:SCDO_0000487, obo:SCDO_0000746, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C39547 ] . obo:SCDO_0000873 obo:IAO_0000115 "A headache disability questionnaire which is completed by the patient and his/her parent and is reviewed with the clinician or study staff. It captures the impact of headaches on school performance (three questions), activities at home (one question on homework or chores), and social and/or sports functions (two questions). It is scored by summing the answers across the six questions. If a range is provided as an answer, either use the high end of the range or prompt for a single answer. The frequency and severity are not scored but can be used for clinical reference." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Migraine - Children\") as we have done." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Migraine - Children #130502" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:130502" ; oboInOwl:hasExactSynonym "PedMIDAS", "Pediatric Migraine Questionnaire" ; a owl:Class ; rdfs:label "Pediatric Migraine Disability Assessment" ; rdfs:subClassOf obo:SCDO_0000760 . obo:SCDO_0000874 obo:IAO_0000115 "A physical assessment of the various symptoms associated with a stroke, consisting of eleven categories. The PedNIHSS was developed by a panel of pediatric and adult stroke experts and is a modification of the adult NIH stroke scale (NIHSS). Modifications were made to allow individuals age 18 or younger to be assessed and are identified in the PedNIHSS by bold italic text." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820802" ; obo:SCDO_0000479 "PhenX protocol: Pediatric NIH Stroke Scale (PedNIHSS) #820802" ; obo:SCDO_0001222 "2-18 years old" ; obo:SCDO_0001335 "Examiners must be trained to administer, score, and interpret the NIHSS. The National Institute of Neurological Disorders and Stroke (NINDS) provides a comprehensive interactive training DVD for the National Institutes of Health Stroke Scale (NIHSS). Information and purchasing details for this training is available on the NINDS website." ; obo:SCDO_1000288 "None" ; oboInOwl:hasDbXref "phenX:820802" ; oboInOwl:hasExactSynonym "PedNIHSS", "Pediatric NIH Stroke Scale" ; a owl:Class ; rdfs:comment "For each category of the PedNIHSS, the examiner asks the respondent to perform an activity or respond to an action by the provider. Respondents receive a score for each category based upon their ability to complete the activity or respond to the action. Each score typically ranges from 0 to 3. Each category of the PedNIHSS is designed to determine the respondent’s level of consciousness (LOC), visual, motor, or language ability." ; rdfs:label "Pediatric NIH Stroke Scale (PedNIHSS)" ; rdfs:subClassOf obo:SCDO_0001112, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000876 obo:IAO_0000115 "A questionnaire to assess educational performance and learning accommodations." ; obo:SCDO_0000303 "Suggest update to label in PhenX as we have done." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Pediatric School Performance #840201" ; obo:SCDO_0000486 "Many rare genetic conditions (e.g., sickle cell disease) and other diseases are associated with developmental delays, damage to the central nervous system, and frequent absences from school due to illness, all of which can impact school performance." ; obo:SCDO_1000288 "Suggest update to label" ; dc:source ; oboInOwl:hasDbXref "phenX:840200" ; a owl:Class ; rdfs:label "Pediatric School Performance Measure" ; rdfs:subClassOf obo:SCDO_0000951, obo:SCDO_1000297, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000877 obo:IAO_0000115 "A generic symptom-specific instrument to measure fatigue across pediatric populations." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Pediatric Quality of Life Inventory\"." ; obo:SCDO_0000340 "Panepinto JA, Torres S, Bendo CB, McCavit TL, Dinu B, Sherman-Bien S, Bemrich-Stolz C, Varni JW (2014). PedsQL Multidimensional Fatigue Scale in sickle cell disease: feasibility, reliability, and validity. Pediatric Blood & Cancer, 61,171-177" ; obo:SCDO_0000481 "Self; Proxy (Parent report)" ; obo:SCDO_0000482 "Clinic patients" ; obo:SCDO_0001033 "Validation study in SCD" ; obo:SCDO_0001222 "Children 2 - 18 (child report ages 5 - 18 years; parent proxy report of children ages 2 - 18 years)" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "The 18-item PedsQL Multidimensional Fatigue Scale encompasses three domains: 1) General Fatigue, 2) Sleep/Rest Fatigue and 3) Cognitive Fatigue. The format, instructions, Likert response scale, and scoring method are identical to the PedsQL 4.0 Generic Core Scales [16], with higher scores indicating better HRQOL (lower fatigue symptoms). The instructions ask how much of a problem each item has been during the past one month." ; rdfs:label "PedsQL Multidimensional Fatigue Scale" ; rdfs:subClassOf obo:NCIT_C78652 . obo:SCDO_0000878 obo:IAO_0000115 "The PedsQL Sickle Cell Disease Module includes 43 items from 9 subscales: Pain and Hurt (9 items); Pain Impact (10 items); Pain Management and Control (2 items); Worry (5 items); Worry II (2 items); Emotions (2 items); Treatment (7 items); Communication I (3 items); and Communication II (3 items). For all ages, each item asks how much of a problem there has been in the past month. There are self- or parent-reported forms for ages 8 to 18, and responses are scored on a 5-point Likert-style scale (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). Forms for children ages 5 to 7 are interviewer-administered, and responses include a 3-point Likert-style scale (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reversed-scored and converted to a 100-point scale (0 = 100, 1 = 75, 2 = 50, 3 = 25, 4 = 0) with higher scores indicating better quality of life. Scores for individual subscales are the sum of items divided by the total number or items answered. The total score for the PedsQL Sickle Cell Disease Module is the sum of the items divided by the number of items answered." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Pediatric Quality of Life Inventory\"." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: PedsQL Sickle Cell Disease Module #820202" ; obo:SCDO_0000481 "Self; Proxy (Parent report)" ; obo:SCDO_0000482 "Clinic Patients (Children with SCD)" ; obo:SCDO_0001222 "Ages 2 to 18" ; obo:SCDO_0001335 "No. The PedsQ Sickle Cell Disease Module is a proprietary instrument and administration requires permission and a license from the MAPI Research Trust." ; obo:SCDO_1000288 "None" ; dc:source "Panepinto JA, Torres S, Bendo CB, McCavit TL, Dinu B, Sherman-Bien S, Bemrich-Stolz C, Varni JW (2013).PedsQL sickle cell disease module: feasibility, reliability, and validity.Pediatric Blood & Cancer, 60,1338-1344." ; a owl:Class ; rdfs:label "PedsQL Sickle Cell Disease Module" ; rdfs:subClassOf obo:NCIT_C78652, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000881 obo:IAO_0000115 "Use of penicillin for the prevention of infections with penicillin-susceptible organisms, e.g. Streptococcus pneumoniae." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Penicillin Prophylaxis" ; rdfs:subClassOf obo:NCIT_C51993, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000882 obo:IAO_0000115 "A method of determining the size of the liver by tapping on the surface of the abdomen." ; obo:SCDO_0000303 "To be requested for inclusion into SNOMED CT, below \"Diagnostic procedure on liver\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Percussion of Liver" ; rdfs:subClassOf obo:SCDO_0000694 . obo:SCDO_0000885 obo:IAO_0000115 "An estimation of the oxygen saturation level usually measured with a pulse oximeter device." ; obo:SCDO_0000303 "Request inclusion into CMO below \"Oxygen Saturation\"" ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Oxygen_saturation_(medicine)" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasDbXref "SNOMEDCT:431314004" ; oboInOwl:hasExactSynonym "Oxygen Saturation of Peripheral Blood", "Peripheral SaO2", "Peripheral Sats", "Peripheral HbO2", "Peripheral Oxyhemoglobin Saturation", "SpO2" ; a owl:Class ; rdfs:label "Peripheral Oxygen Saturation" ; rdfs:subClassOf obo:CMO_0001324, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000945 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:SCDO_0000944 ] . obo:SCDO_0000895 obo:IAO_0000115 "A (combination of) quality(ies) of some or all sickle cell disease individuals, determined by the interaction of the genetic make-up of these individuals (with regard to sickle cell disease) and their environment." ; obo:SCDO_0000303 """Probably too specific to warrant inclusion into anther ontology. Make sure complications as described in \"Definitions of the Phenotypic Manifestations of Sickle Cell Disease\" (Ballas, 2010) are included in Phenotype.""" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/OGMS?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FOGMS_0000023" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasDbXref "OGMS:0000023" ; a owl:Class ; rdfs:label "Phenotype of Sickle Cell Disease" ; rdfs:subClassOf obo:HP_0000118, obo:OGMS_0000028, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:HP_0011904 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0001386 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0008713 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_1000060 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_1000061 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_1000707 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000952 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_1000060 ] . obo:SCDO_0000896 obo:IAO_0000115 "The physical method (technology) used to measure / readout the effect caused by a perturbagen in the assay environment." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000896" ; oboInOwl:hasDbXref "BAO:0000035" ; a owl:Class ; rdfs:label "Physical Detection Method" ; rdfs:subClassOf obo:SCDO_0000082 . obo:SCDO_0000897 obo:IAO_0000115 "The part of the human environment that consists of purely physical factors, including the natural environment (such as soil, climate, water supply) and the built environment." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Physical Environment. Merriam-Webster.com. Merriam-Webster, n.d. Web. 9 Nov. 2016." ; obo:SCDO_1000288 "Few but definitions not freely available" ; a owl:Class ; rdfs:label "Physical Environment" ; rdfs:subClassOf obo:SCDO_0000435 . obo:SCDO_0000898 obo:IAO_0000115 "Systematic and thorough inspection of the patient for physical signs of disease or abnormality." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D010808" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000898" ; oboInOwl:hasDbXref "MESH:D010808" ; oboInOwl:hasExactSynonym "Physical Assessment" ; a owl:Class ; rdfs:label "Physical Examination" ; rdfs:subClassOf obo:SCDO_0000082 . obo:SCDO_0000900 obo:IAO_0000115 "One's ability to carry out activities that require physical actions, ranging from self-care (activities of daily living) to more complex activities that require a combination of skills, often within a social context. Physical function is inclusive of the term disability and includes the full spectrum of physical functioning from severe impairment to exceptional physical abilities." ; obo:SCDO_0000303 "Determine and specify the description source. -- -- Include a term to do with level of independence?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Mobility", "Motor Function", "Physical Function", "Physical Health" ; a owl:Class ; rdfs:label "Physical Functioning" ; rdfs:subClassOf obo:NCIT_C17047, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C17047 ] . obo:SCDO_0000902 obo:IAO_0000115 "An organismal assay designed to capture information pertaining to the organic processes and phenomena of an organism or any of its parts or of a particular bodily process." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0001292" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000902" ; oboInOwl:hasDbXref "ERO:0001292" ; a owl:Class ; rdfs:label "Physiological Assay" ; rdfs:subClassOf obo:SCDO_0000082 . obo:SCDO_0000903 obo:IAO_0000115 "A therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OAE_0002476" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000903" ; oboInOwl:hasDbXref "OAE:0002476" ; oboInOwl:hasExactSynonym "Physical Therapy" ; a owl:Class ; rdfs:label "Physiotherapy" ; rdfs:subClassOf obo:SCDO_0000978, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1188 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001271 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001342 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001369 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001370 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002341 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002650 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003302 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0010628 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0011868 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0100774 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C26702 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000032 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000812 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:SCDO_0000905 obo:IAO_0000115 "Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D010865" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000905" ; oboInOwl:hasDbXref "MESH:D010865" ; oboInOwl:hasExactSynonym "Pilot Study" ; a owl:Class ; rdfs:label "Pilot Projects" ; rdfs:subClassOf obo:SCDO_0300004 . obo:SCDO_0000908 obo:IAO_0000115 "A nonincisional procedure that has become a well-accepted alternative to scleral buckling and vitrectomy for the repair of selected cases of rhegmatogenous retinal detachment." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://emedicine.medscape.com/article/1844217-overview" ; obo:SCDO_1000288 "Few but definitions not freely available" ; a owl:Class ; rdfs:label "Pneumatic Retinopexy" ; rdfs:subClassOf obo:SCDO_0000833 . obo:SCDO_0000913 obo:IAO_0000115 "The process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As the process progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified." ; obo:SCDO_0000303 "Suggest update to description in OBI" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/OBI_0000415" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "OBI:0000415" ; oboInOwl:hasExactSynonym "PCR" ; a owl:Class ; rdfs:label "Polymerase Chain Reaction" ; rdfs:subClassOf obo:SCDO_0000448 . obo:SCDO_0000917 obo:IAO_0000115 "'Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D065007" ; oboInOwl:hasDbXref "MESH:D065007" ; a owl:Class ; rdfs:label "Pragmatic Clinical Trial" ; rdfs:subClassOf obo:SCDO_0000965 ; owl:deprecated true . obo:SCDO_0000919 obo:IAO_0000115 "Prenatal detection of a fetus affected with Sickle Cell Disease using appropriate laboratory techniques. Detection of affected fetuses allows couples to make informed decisions regarding the pregnancy." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. Perhaps in SNOMED CT below \"Screening for sickle cell disease\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "Prenatal Screening for Sickle Cell" ; rdfs:subClassOf obo:SCDO_0001049 . obo:SCDO_0000922 obo:IAO_0000115 "Activities to prevent Sickle Cell Disease or its complications." ; obo:SCDO_0000303 """Probably too specific to SCD to be included in other ontologies. Consider making the description more generic (e.g. \"Activities to prevent a disease or its complications.\")""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Preventive Therapeutics", "Prophylactic Therapeutics" ; a owl:Class ; rdfs:label "Preventative Therapeutics" ; rdfs:subClassOf obo:SCDO_0001152 . obo:SCDO_0000923 obo:IAO_0000115 "A prolonged painful erection that may last hours and is not associated with sexual activity. It is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma, and certain drug treatments." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011317" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000923" ; oboInOwl:hasDbXref "MESH:D011317" ; a owl:Class ; rdfs:label "Priapism" ; rdfs:subClassOf obo:HP_0000080, obo:SCDO_0000016, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000924 obo:IAO_0000115 "Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community." ; obo:SCDO_0000303 "This term is not below Quality of Health Care in MESH, but below \"Health Services Administration\" ---> \"Patient Care Management\" ---> \"Comprehensive Health Care" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011320" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000924" ; oboInOwl:hasDbXref "MESH:D011320" ; oboInOwl:hasExactSynonym "Primary Care", "Primary Health Care" ; a owl:Class ; rdfs:label "Primary Healthcare" ; rdfs:subClassOf obo:SCDO_0000494 . obo:SCDO_0000925 obo:IAO_0000115 "A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. Cycloguanil stops the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite." ; obo:SCDO_0000303 "Suggest update to description in MESH" ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D002727" ; oboInOwl:hasExactSynonym "1-(P-Chlorophenyl)-5-isopropylbiguanide", "Chlorguanid", "Chlorguanide", "Chloroguanide", "N-(4-Chlorophenyl)-n'-(isopropyl)-imidodicarbonimidic diamide" ; a owl:Class ; rdfs:label "Proguanil" ; rdfs:subClassOf obo:IDOMAL_0000122, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:SCDO_0000926 obo:IAO_0000115 "Sickle retinopathy that involves the upregulation of vascular growth factors due to chronic changes of local hypoxia and ischemia." ; obo:SCDO_0000303 "Request inclusion into HPO below \"Retinopathy/Sickle Retinopathy\"." ; obo:SCDO_0000340 "http://eyewiki.aao.org/Sickle_Cell_Retinopathy" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Retinopathy due to SCD Characterized by Neovascularization", "Sickle Cell Proliferative Retinopathy" ; a owl:Class ; rdfs:label "Proliferative Sickle Retinopathy" ; rdfs:subClassOf obo:SCDO_0001067, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C101217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C75583 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001327 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0000927 obo:IAO_0000115 "This protocol includes 29 self-administered quality of life-type questions from the PROMIS Profile 29 for adults. The quality of life questions include physical function, anxiety, depression, fatigue, sleep disturbance, ability to participate in social roles and activities, and pain intensity over the past 7 days. Each question, except for the pain intensity question, is measured on a 5-point scale." ; obo:SCDO_0000303 "Suggest update to label in PhenX as we have done." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=221302" ; obo:SCDO_0000479 "PhenX protocol: Quality of Life - Adult #221302" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasExactSynonym "PROMIS 25 Profie v2.0" ; a owl:Class ; rdfs:label "PROMIS Adult Profile 29" ; rdfs:subClassOf obo:NCIT_C102988, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000928 obo:IAO_0000115 "This protocol includes 25 quality of life-type questions relating to physical function mobility, anxiety, depressive symptoms, fatigue, peer relationships, pain interference, and pain intensity over the past 7 days." ; obo:SCDO_0000303 "Suggest update to label in PhenX as we have done." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=221301" ; obo:SCDO_0000479 "PhenX protocol: Quality of Life - Pediatric #221301" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasExactSynonym "PROMIS 25", "PROMIS 25 Profie" ; a owl:Class ; rdfs:label "PROMIS Pediatric Profile 25" ; rdfs:subClassOf obo:NCIT_C102988, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000929 obo:IAO_0000115 "Description inherent in name (not provided by source)" ; obo:SCDO_0000363 "Only label adapted" ; obo:SCDO_0000929 "organizational term" ; a owl:AnnotationProperty ; rdfs:comment """Used for properties, not classes. For classes, use \"has curation status\" object property.""" ; rdfs:label "property has curation status" . obo:SCDO_0000930 obo:IAO_0000115 "A planned process that has the objective to reduce the risk of acquiring one or more infections." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "http://purl.obolibrary.org/obo/OGMS_0000103" ; oboInOwl:hasExactSynonym "Disease Prevention" ; a owl:Class ; rdfs:label "Infection Prophylaxis" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0000922, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:MP_0002412 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000931 obo:IAO_0000115 "Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011446" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000931" ; oboInOwl:hasDbXref "MESH:D011446" ; oboInOwl:hasExactSynonym "Prospective Study" ; a owl:Class ; rdfs:label "Prospective Studies" ; rdfs:subClassOf obo:SCDO_0000263 . obo:SCDO_0000932 obo:IAO_0000115 "Increased amounts of any protein (including albumin) in the urine - typically more than 300mg in a 24hr period." ; obo:SCDO_0000303 "Suggest update to description in HPO." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0000093" ; obo:SCDO_0000468 "In sickle cell disease, overt proteinuria (distinguised from albuminuria) may be noted in childhood although less common (4.5% in ages 2-21 [Wigfall 2000] v. 26% in adults [Guasch 2006])." ; obo:SCDO_0000472 "At most severe form - lead to nephrotic syndrome." ; obo:SCDO_0000661 "Caused by a variety of kidney diseases, including sickle cell disease, diabetes, glomerular disease, arteriosclerosis." ; obo:SCDO_0000662 "Elevated amounts of protein in the urine - typically greater than 300mg in 24 hrs." ; obo:SCDO_1000288 "Suggest update to description" ; dc:source ; oboInOwl:hasDbXref "HP:0000093" ; oboInOwl:hasExactSynonym "High Urine Protein Levels" ; a owl:Class ; rdfs:comment "Screening Recommendations: Screen all individuals with SCD, beginning by age 10, for proteinuria. If the result is negative, repeat screening annually. If the result is positive, perform a first morning void urine albumin-creatinine ratio and if abnormal, consult with or refer to a renal specialist." ; rdfs:label "Proteinuria" ; rdfs:subClassOf obo:HP_0003110, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000055 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001207 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001210 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000220 ; owl:someValuesFrom obo:SCDO_0001212 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0000934 obo:IAO_0000115 "This is a 17-item scale, separated into 4 subscales with good psychometric properties. Negative Attitudes Scale comprises six items grouped together (Mean=36.5, SD=21.9, Potential range = 0 to 100). Higher scores on this scale indicate an endorsement of more negative views about SCD patients. Positive Attitudes Scale comprises four items grouped together (Mean=45.7, SD=24.3, Potential range = 0 to 100). Higher scores indicate an endorsement of more positive views about SCD patients. Concern Raising Behaviors Scale comprises four items grouped together (Mean = 53.7, SD = 22.0, Potential range = 0 to 100). Higher scores indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern that the patient is inappropriately drug-seeking. Red-Flag Behaviors Scale comprises three items grouped together (Mean = 58.7, SD = 22.7, Potential range = 0 to 100). Higher scores on this scale indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern about patient drug-seeking." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Haywood, Jr., C., Lanzkron, S., Hughes, MD3, Brown, R., Massa, M., Ratanawongsa, N., and Beach, MC. (2010). A Video-Intervention to Improve Clinician Attitudes Toward Patients with Sickle Cell Disease: The Results of a Randomized Experiment. J Gen Intern Med 26(5):518–23." ; obo:SCDO_0000470 "African Americans" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Heath care providers" ; obo:SCDO_0001033 "Demonstrated validity with SCD populations in the US" ; obo:SCDO_0001222 "Adults" ; obo:SCDO_1000288 "None" ; dc:source "Haywood, Jr., C., Lanzkron, S., Hughes, MD3, Brown, R., Massa, M., Ratanawongsa, N., and Beach, MC. (2010). A Video-Intervention to Improve Clinician Attitudes Toward Patients with Sickle Cell Disease: The Results of a Randomized Experiment. J Gen Intern Med 26(5):518–23." ; a owl:Class ; rdfs:label "Provider Attitudes Toward Patients with Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_0000947 . obo:SCDO_0000935 obo:IAO_0000115 "Pruritus, or itch, is defined as an unpleasant sensation that provokes the desire to scratch." ; obo:SCDO_0000303 "Suggest update to description. The current description seems to be describing two different things in the same description." ; obo:SCDO_0000340 obo:HP_0000989 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0000989" ; oboInOwl:hasExactSynonym "Itchy Skin", "Skin Itching" ; a owl:Class ; rdfs:label "Pruritus" ; rdfs:subClassOf obo:HP_0000961, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000937 obo:IAO_0000115 "Stress wherein emotional factors predominate." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000937" ; oboInOwl:hasDbXref "MESH:D013315" ; oboInOwl:hasExactSynonym "Emotional Stress", "Life Stress", "Psychological Suffering" ; a owl:Class ; rdfs:label "Psychological Stress" ; rdfs:subClassOf obo:SCDO_0000746, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000938 obo:IAO_0000115 "The absence of appropriate stimuli in the physical or social environment which are necessary for the emotional, social, and intellectual development of the individual." ; obo:SCDO_0000303 "This term is placed below \"Culture\" in MESH." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011610" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000938" ; oboInOwl:hasDbXref "MESH:D011610" ; oboInOwl:hasExactSynonym "Psychosocial Deprivations" ; a owl:Class ; rdfs:label "Psychosocial Deprivation" ; rdfs:subClassOf obo:SCDO_0000299, obo:SCDO_0000746 . obo:SCDO_0000940 obo:IAO_0000115 "A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011613" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000940" ; oboInOwl:hasDbXref "MESH:D011613" ; oboInOwl:hasExactSynonym "Logotherapy", "Psycho-Therapy" ; a owl:Class ; rdfs:label "Psychotherapy" ; rdfs:subClassOf obo:SCDO_0001129, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000360 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0000941 obo:IAO_0000115 "'Describes the type of material the article represents (e.g., Review, Clinical Trial, Retracted Publication, Letter); see the PubMed Publication Types, e.g., review[pt]. Publication Types are arranged hierarchically with more specific terms arranged beneath broader terms. [Curator team: []]'" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/EDDA_PT?p=classes&conceptid=http%3A%2F%2Fontologies.dbmi.pitt.edu%2Fedda%2FPublicationType.owl%23publication_type" ; a owl:Class ; rdfs:label "obsolete Publication Type" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_0000942 obo:IAO_0000115 "Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000942" ; oboInOwl:hasDbXref "MESH:D012129" ; oboInOwl:hasExactSynonym "Lung Function Test", "PFT", "Respiratory Function Test" ; a owl:Class ; rdfs:label "Pulmonary Function Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:SCDO_0000943 obo:IAO_0000115 "An elevation of mean pulmonary arterial systolic pressure (mPASP) (>20 mmHg at rest or >30 mmHg with exercise). The 6th World Symposium on PH reduced it from >25mmHg to >20mmHg for at rest, but did not adjust the definition for PH with exercise." ; obo:SCDO_0000340 "Br J Haematol. 2006 Jul;134(1):109-15.", "Simonneau et al 2013 J Am Coll Cardiol; Ataga et al." ; obo:SCDO_0000661 "Multifactorial, including chronic thromboembolism, splenectomy, high cardiac output, left-heart disease, and hyperviscosity; the role of an inactivation of nitric oxide by free plasma hemoglobin due to chronic hemolysis is controversial." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source ; oboInOwl:hasExactSynonym "Increased Blood Pressure in Blood Vessels of Lungs", "Pulmonary Arterial Hypertension" ; a owl:Class ; rdfs:comment "Pulmonary hypertension can be secondary to known cardiac, pulmonary, or hepatic disease. If no cause is identifiable, the term primary pulmonary hypertension is used." ; rdfs:label "Pulmonary Hypertension" ; rdfs:subClassOf obo:HP_0000822, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000787 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0000944 obo:IAO_0000115 "A measurement device, usually attached to the earlobe or fingertip, that measures the oxygen saturation of arterial blood." ; obo:SCDO_0000303 "This consists of 2 parts, the \"pulse oximeter monitor\" and the \"pulse oximeter probe\". Perhaps can be included as sub-classes or siblings? See \"Pulse Oximetry (Rest)\" in PhenX." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0000876" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000944" ; oboInOwl:hasDbXref "ERO:0000876" ; oboInOwl:hasExactSynonym "Blood Oxygen Monitor", "Oxygen Monitor" ; a owl:Class ; rdfs:label "Pulse Oximeter" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000474 ; owl:someValuesFrom obo:SCDO_0000885 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000945 ] . obo:SCDO_0000945 obo:IAO_0000115 "The application of pulse oximetry to measure a patient's saturation of oxyhemoglobin when the patient is at rest." ; obo:SCDO_0000303 """Suggest update to description in PhenX Suggest inclusion of term below \"Pulse Oximetry\" in the CMO.""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Pulse Oximetry (Rest) #91102" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "phenX:91102" ; a owl:Class ; rdfs:label "Pulse Oximetry (Rest)" ; rdfs:subClassOf obo:NCIT_C38085, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0000944 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000885 ] . obo:SCDO_0000947 obo:IAO_0000115 "The systemic measurement of the quality of health care that includes a broad set of perfomance measures such as the quality of services and the outcomes analysis for particular diseases and conditions, mortality and morbidity, patient safety, data on maternal and child health, as well as evaluation of quality of diagnosis, care accessibility, implementation of proven evidence-based practices, quality of reporting systems for errors and adverse events, reliability and accessibility of health and health care-related information, and health care organizations infrastructure." ; obo:SCDO_0000303 "Suggest update to description in EDDA (replace \"excessability\" with \"accessibility\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "EDDA:health_care_quality_assessment" ; oboInOwl:hasExactSynonym "Health Care Quality Assessment", "Quality of Health Care Assessment" ; a owl:Class ; rdfs:label "Quality of Care Measure" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0000948 obo:IAO_0000115 "The levels of excellence which characterize the health service or health care provided based on accepted standards of quality." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011787" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000948" ; oboInOwl:hasDbXref "MESH:D011787" ; oboInOwl:hasExactSynonym "Health Care Quality", "Healthcare Quality", "Quality of Healthcare" ; a owl:Class ; rdfs:label "Quality of Health Care" ; rdfs:subClassOf obo:SCDO_0000950, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:NCIT_C17047 ] . obo:SCDO_0000950 obo:IAO_0000115 "The subjective measurement of an individual's sense of well-being and ability to enjoy life, and the levels of excellence which characterize the health service or health care provided to individuals based on accepted standards of quality." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Include the term \"Transition from pediatric care\" somewhere...see the source provided here.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source ; a owl:Class ; rdfs:label "Quality of Life and Care" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_0000951 obo:IAO_0000115 "A measurement tool that is useful in aiding routine clinical practice with regard to quality of life and/or quality of care." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Quality of Life and Care Measurement Scales" ; a owl:Class ; rdfs:label "Quality of Life and Care Measure" ; rdfs:subClassOf obo:SCDO_0000950 . obo:SCDO_0000952 obo:IAO_0000115 "A questionnaire to assess the physical, emotional, and social impact of chronic conditions, such as sickle cell disease (SCD)." ; obo:SCDO_0000303 "Suggest update to label in PhenX." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:820200" ; oboInOwl:hasExactSynonym "Quality of Life in SCD" ; a owl:Class ; rdfs:label "Quality of Life in Sickle Cell Disease Measure" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000234 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000895 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0001023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0001052 ] . obo:SCDO_0000953 obo:IAO_0000115 "A measurement tool with eight potential uses in aiding routine clinical practice. It can be used to prioritise problems, facilitate communication, screen for potential problems, identify preferences, monitor changes or response to treatment, and train new staff. It can also be used in clinical audit and in clinical governance. The first five of these can be used in the clinical encounter, while the last three contribute to training, reviewing care, and improving care in the future." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Quality of Life Measure" ; rdfs:subClassOf obo:SCDO_0000951, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000954 obo:IAO_0000115 "Sickle cell symptoms where there is evidence of some relation with quality of life." ; obo:SCDO_0000303 "Probably too specific to be included in other ontologies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Quality of Life Related SCD Symptoms and Complications" ; rdfs:subClassOf obo:NCIT_C17047 . obo:SCDO_0000955 obo:IAO_0000115 "QALYs are used primarily to correct a person's life expectancy based on the levels of health-related quality of life they are predicted to experience throughout the course of their life, or part of it." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self; Proxy" ; obo:SCDO_0000482 "All" ; obo:SCDO_0001033 "Standard global assessment of health interventions, also used in SCD studies" ; obo:SCDO_0001222 "Children and adults" ; obo:SCDO_0001335 "no" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasExactSynonym "QALY", "Quality-Adjusted Life Year" ; a owl:Class ; rdfs:comment "The number of QALYs lived by an individual in one year is simply: QALYs lived in one year = 1 * Q with Q <= 1; where Q is the health-related quality of life weight attached to the relevant year of life. I.e. QALY assumes a utility value (quality of life) of 1 = perfect health and a utility value of 0 = dead: Years of Life x Utility Value = Number of QALYs. E.g. If a person lives in perfect health for one year, that person will have 1 QALY (1 Year of Life x 1 Utility Value = 1 QALY), If a person lives in perfect health but only for half a year, that person will have 0.5 QALYs (0.5 Years of Life x 1 Utility Value = 0.5 QALYs) OR if a person lives for 1 year in a situation with 0.5 utility (half of perfect health), that person will also have 0.5 QALYs (1 Year of Life x 0.5 Utility Value = 0.5 QALYs). In cost-effectiveness evaluations the QALY is used to quantify the effectiveness of, for instance, a new medication versus the current one. In other words, the current standard of care is taken as the baseline, and the QALYs gained from the new (improved) intervention are counted in addition." ; rdfs:label "Quality-Adjusted Life Year (QALY)" ; rdfs:subClassOf obo:SCDO_0000495, obo:SCDO_0000951 . obo:SCDO_0000957 obo:IAO_0000115 "'Collection of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. [Curator team: []]'" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/MESH?p=classes&conceptid=D011795" ; oboInOwl:hasDbXref "MESH:D011795" ; a owl:Class ; rdfs:label "obsolete Questionnaire" ; rdfs:subClassOf obo:SCDO_1000034 ; owl:deprecated true . obo:SCDO_0000963 obo:IAO_0000115 "Examination of any part of the body for diagnostic purposes by means of x-rays or gamma rays, recording the image on a sensitized surface (such as photographic film)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011859" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000963" ; oboInOwl:hasDbXref "MESH:D011859" ; oboInOwl:hasExactSynonym "Imaging by X-Ray", "X-Ray" ; a owl:Class ; rdfs:label "Radiography" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:OBI_0001138 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000964 obo:IAO_0000115 "The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D011877" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000964" ; oboInOwl:hasDbXref "MESH:D011877" ; oboInOwl:hasExactSynonym "Imaging by Radionuclide", "Scintigraphy" ; a owl:Class ; rdfs:label "Radionuclide Imaging" ; rdfs:subClassOf obo:OBI_0000185 . obo:SCDO_0000965 obo:IAO_0000115 "'A work that reports on a clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016449" ; oboInOwl:hasDbXref "MESH:D016449" ; a owl:Class ; rdfs:label "obsolete Randomized Controlled Trial" ; rdfs:subClassOf obo:SCDO_0000283 ; owl:deprecated true . obo:SCDO_0000966 obo:IAO_0000115 "The Rapid Estimate of Adolescent Literacy or REALM-Teen is a valid, reliable, easy-to-administer tool that will allow health professionals to screen youth in grades 6-12 for below-grade reading. The REALM-Teen is a reading recognition instrument, modeled after the Rapid Estimate of Adult Literacy in Medicine (REALM), the most commonly used tool to screen adults for low literacy in health care settings. The REALM-Teen is a reading recognition instrument which measures an individual's ability to pronounce words in ascending order of difficulty. All test words are commonly used adolescent health terms." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Research or Clinical Assessment Tool\". Add these annotation properties: -- has cross-cultural adaptation -- freely available -- has translations""" ; obo:SCDO_0000340 "Davis TC, Wolf MS, Arnold CL, Byrd RS, Long SW, Springer T, Kennen E, Bocchini JA. (2006). Development and validation of the Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen): a tool to screen adolescents for below-grade reading in health care settings. Pediatrics 118(6):e1707-14." ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Adolescents with SCD" ; obo:SCDO_0001033 "Used in SCD studies" ; obo:SCDO_0001222 "Adolescents" ; obo:SCDO_1000288 "None" ; dc:source "Davis TC, Wolf MS, Arnold CL, Byrd RS, Long SW, Springer T, Kennen E, Bocchini JA. (2006). Development and validation of the Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen): a tool to screen adolescents for below-grade reading in health care settings. Pediatrics 118(6):e1707-14." ; oboInOwl:hasExactSynonym "REALM-Teen", "Rapid Estimate of Adolescent Literacy in Medicine" ; a owl:Class ; rdfs:label "Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0000970 obo:IAO_0000115 "A questionnaire that assesses recovery and recurrence of stroke in children. It is completed by a parent about their child." ; obo:SCDO_0000303 "Suggest update to description in PhenX." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820702" ; obo:SCDO_0000479 "PhenX protocol: Recovery and Recurrence Questionnaire (RRQ) - Pediatrics #820702" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "phenX:820702" ; oboInOwl:hasExactSynonym "RRQ", "Recovery and Recurrence Questionnaire (RRQ) - Pediatrics" ; a owl:Class ; rdfs:label "Recovery and Recurrence Questionnaire (RRQ)" ; rdfs:subClassOf obo:SCDO_0001339, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0000972 obo:IAO_0000115 "Recurrent episodes of wheezing in persons with SCD who have no co-morbid asthma." ; obo:SCDO_0000303 "Probably too specific to warrant inclusion into anther ontology." ; obo:SCDO_0000340 "Glassberg et al 2014 Curr Opin Pediatr.", "Knight-Madden et al 2014 Ped Resp Rev" ; obo:SCDO_0000661 "Likely related to inflammation of SCD." ; obo:SCDO_0000662 "Other markers of severity of SCD- eg complications of SCD, high LDH." ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "RWIS" ; a owl:Class ; rdfs:label "Recurrent Wheeze in Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_0000895, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000580 ] . obo:SCDO_0000975 obo:IAO_0000115 "The amount of red blood cell derived microparticles in a specific volume of blood." ; obo:SCDO_0000303 """Request inclusion into relevant ontology More info can be taken from the dc:source provided. Perhaps add MeSH term \"Cell-Derived Microparticles\" as a superclass of this term?""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasBroadSynonym "Cell-Derived Microparticles" ; oboInOwl:hasExactSynonym "EMP Level", "Erythrocyte-Derived Microparticles Level", "Level of Red Blood Cell Microparticles", "RBC Microparticles Level", "Red Blood Cell Derived Microparticles Level" ; a owl:Class ; rdfs:label "Red Blood Cell Microparticles Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001326 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000314 ] . obo:SCDO_0000976 obo:IAO_0000115 "Hemoglobin A (HbA) contains two alpha-globin chains and two beta-globin chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decrease in the proportion of HbA below this limit, and can be seen in various forms of thalassemia." ; obo:SCDO_0000303 "Suggest update to description in HPO." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0011905" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0011905" ; a owl:Class ; rdfs:label "Reduced Hemoglobin A" ; rdfs:subClassOf obo:HP_0020062, obo:SCDO_1000061, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0009731 ] . obo:SCDO_0000978 obo:IAO_0000115 "Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012046" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000978" ; oboInOwl:hasDbXref "MESH:D012046" ; oboInOwl:hasExactSynonym "Habilitation" ; a owl:Class ; rdfs:label "Rehabilitation" ; rdfs:subClassOf obo:SCDO_0001129 . obo:SCDO_0000979 obo:IAO_0000115 "Reincarnation is the philosophical or religious concept that an aspect of a living being starts a new life in a different physical body or form after each biological death." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Reincarnation" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Rebirth", "Transmigration" ; a owl:Class ; rdfs:label "Reincarnation" ; rdfs:subClassOf obo:SCDO_0000107 . obo:SCDO_0000981 obo:IAO_0000115 "A set of beliefs concerning the nature, cause, and purpose of the universe, especially when considered as the creation of a superhuman agency. It usually involves devotional and ritual observances and often a moral code for the conduct of human affairs." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012067" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000981" ; oboInOwl:hasDbXref "MESH:D012067" ; oboInOwl:hasExactSynonym "Religious Beliefs", "Religious Ethics" ; a owl:Class ; rdfs:label "Religion" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_0000299 . obo:SCDO_0000983 obo:IAO_0000115 "Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, peritoneal dialysis, and hemodiafiltration." ; obo:SCDO_0000303 "Include types of renal dialysis as sub-classes: -- Peritoneal dialysis -- Hemodialysis -- Pediatric dialysis? -- Hemofiltration -- Hemodiafiltration" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006435" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000983" ; oboInOwl:hasDbXref "MESH:D006435" ; oboInOwl:hasExactSynonym "Dialyses, Renal", "Extracorporeal Dialyses", "Extracorporeal Dialysis", "Haemodialysis", "Hemodialyses", "Renal Dialyses" ; a owl:Class ; rdfs:label "Renal Dialysis" ; rdfs:subClassOf obo:SCDO_1000004, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001298 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001919 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002157 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002913 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003774 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0008682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0000984 obo:IAO_0000115 "Inadequate blood flow to one or both kidneys, or nephrons, usually due to functional constriction or actual obstruction of blood vessels." ; obo:SCDO_0000303 """Suggest update to description in Mammalian Phenotype ontology. Provide source for additional info.""" ; obo:SCDO_0000340 obo:MP_0011758 ; obo:SCDO_0000661 "Loss of adequate blood flow may be due to obstruction of blood vessels - large or small or due to low flow states such as prolonged hypotension." ; obo:SCDO_0000662 "Usually associated with kidney injury as noted by decrease in urine output and/or elevation in serum creatinine." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MP:0011758" ; oboInOwl:hasExactSynonym "Kidney Ischaemia", "Kidney Ischemia", "Nephric Ischaemia", "Nephric Ischemia", "Renal Ischaemia" ; a owl:Class ; rdfs:label "Renal Ischemia" ; rdfs:subClassOf obo:HP_0000077, obo:SCDO_0000665, obo:SCDO_1000383, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001129 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000985 obo:IAO_0000115 "The transference of a kidney from one human or animal to another." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016030" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000985" ; oboInOwl:hasDbXref "MESH:D016030" ; oboInOwl:hasExactSynonym "Kidney Grafting", "Kidney Transplant", "Kidney Transplantation", "Kidney Transplantations", "Renal Transplantation", "Renal Transplantations" ; a owl:Class ; rdfs:label "Renal Transplant" ; rdfs:subClassOf obo:SCDO_1000004, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003774 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000226 ] . obo:SCDO_0000986 obo:IAO_0000115 "Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia." ; obo:SCDO_0000303 """Suggest update to description in HPO. Provide source for additional info.""" ; obo:SCDO_0000340 obo:HP_0001947 ; obo:SCDO_0000472 "Has multiple types - Type 1 (Distal RTA), Type 2 (Proximal RTA), Type 4 (Hyperkalemic RTA). Sickle cell disease may demonstrate a voltage dependent Type 1 RTA." ; obo:SCDO_0000661 "Defects in the kidneys in reabsorption of bicarbonate (HCO3), the excretion of hydrogen ions (H+), or both." ; obo:SCDO_0000662 "A relatively normal GFR and a metabolic acidosis accompanied by hyperchloremia and a normal plasma anion gap." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0001947" ; oboInOwl:hasExactSynonym "Accumulation of Acid in Body Due to Kidney Problem", "RTA" ; a owl:Class ; rdfs:label "Renal Tubular Acidosis" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0000987 obo:IAO_0000115 "A questionnaire to assess either male or females' pregnancy history. Females are asked about the number of pregnancies, description of pregnancies and smoking during pregnancy. Males are asked whether they have ever fathered a pregnancy and, if so, the description of the pregnancy." ; obo:SCDO_0000303 """Suggest update to labels of as we have done. We are using \"Reproductive History\" below Personal Attribute. Also suggest update to description as we have done.""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label and description" ; oboInOwl:hasDbXref "phenX:101300" ; a owl:Class ; rdfs:label "Reproductive History Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ] . obo:SCDO_0000988 obo:IAO_0000115 "'Anatomical system that has as its parts the organs concerned with reproduction. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000263 ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/UBERON_0000990" ; oboInOwl:hasDbXref "UBERON:0000990" ; a owl:Class ; rdfs:label "deprecated Reproductive System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0000990 obo:IAO_0000115 "'Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered. [Curator team: []]'" ; obo:SCDO_0000303 "Consider other sub-classes of this in NCIT." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15429" ; oboInOwl:hasDbXref "NCIT:C15429" ; a owl:Class ; rdfs:label "obsolete Research Activity" ; rdfs:subClassOf obo:SCDO_1000031 ; owl:deprecated true . obo:SCDO_0000993 obo:IAO_0000115 "The number of times an organism breathes with the lungs (respiration) per unit time, usually per minute." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000993" ; oboInOwl:hasDbXref "MESH:D056152" ; oboInOwl:hasExactSynonym "Breathing Frequency", "Pulmonary Ventilation Rate", "Respiration Rate" ; a owl:Class ; rdfs:label "Respiratory Rate" ; rdfs:subClassOf obo:CMO_0000094, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:NCIT_C50474 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:NCIT_C50767 ] . obo:SCDO_0000994 obo:IAO_0000115 "Lungs and respiratory system of the body." ; obo:IAO_0100001 obo:SCDO_0004899 ; oboInOwl:hasExactSynonym "Pulmonary System" ; a owl:Class ; rdfs:label "deprecated Respiratory System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001000 obo:IAO_0000115 "Root of all terms in the Sickle Cell Disease Ontology, an effort of unambiguously describing all concepts and unifying up-to-date knowledge in sickle cell disease." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Gaston K. Mazandu)" ; oboInOwl:hasExactSynonym "Sickle Cell Disease Ontology" ; a owl:Class ; rdfs:label "SCDO" ; rdfs:subClassOf owl:Thing . obo:SCDO_0001002 obo:IAO_0000115 "PCR-restriction fragment length polymorphism (RFLP)-based analysis, also known as cleaved amplified polymorphic sequence (CAPS), is a popular technique for genetic analysis. It has been applied for the detection of intraspecies as well as interspecies variation. There exist several techniques that are related with PCR-RFLP and also involve gel electrophoresis including techniques for DNA fingerprinting and expression profiling." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "Henrik Berg Rasmussen (April 4th 2012). Restriction Fragment Length Polymorphism Analysis of PCR-Amplified Fragments (PCR-RFLP) and Gel Electrophoresis - Valuable Tool for Genotyping and Genetic Fingerprinting, Gel Electrophoresis Sameh Magdeldin, IntechOpen, DOI: 10.5772/37724. Available from: https://www.intechopen.com/books/gel-electrophoresis-principles-and-basics/restriction-fragment-length-polymorphism-analysis-of-pcr-amplified-fragments-pcr-rflp-and-related-te" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "PCR-RFLP", "Restriction Fragment Length Polymorphism - Polymerase Chain Reaction" ; a owl:Class ; rdfs:label "Restriction Fragment Length Polymorphism PCR" ; rdfs:subClassOf obo:SCDO_0000913 . obo:SCDO_0001004 obo:IAO_0000115 "The number of reticulocytes per unit volume of blood. The values are expressed as a percentage of the erythrocyte count or in the form of an index (\"corrected reticulocyte index\"), which attempts to account for the number of circulating erythrocytes." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Reticulocyte Count #810601" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001004" ; oboInOwl:hasDbXref "MESH:D017701" ; oboInOwl:hasExactSynonym "Reticulocyte Number" ; a owl:Class ; rdfs:label "Reticulocyte Count" ; rdfs:subClassOf obo:CMO_0000025, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000686 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0001896 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0001923 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000834 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0001005 obo:IAO_0000115 "A reticulocyte count that was performed with an electronic haematology analyzer." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Reticulocyte Count by Hematology Analyzer" ; rdfs:subClassOf obo:SCDO_0001004 . obo:SCDO_0001006 obo:IAO_0000115 "A reticulocyte count that was performed with microscopy." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Reticulocyte Count by Microsocopy" ; rdfs:subClassOf obo:SCDO_0001004 . obo:SCDO_0001007 obo:IAO_0000115 "A procedure that uses intense cold to induce a chorioretinal scar and to destroy retinal or choroidal tissue." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.surgeryencyclopedia.com/Pa-St/Retinal-Cryopexy.html" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Retinal Cryotherapy" ; a owl:Class ; rdfs:label "Retinal Cryopexy" ; rdfs:subClassOf obo:SCDO_0000833 . obo:SCDO_0001008 obo:IAO_0000115 "Separation of the retina from the choroid and eye wall due to holes in the retina and traction on the retina by vitreous bands and condensed preretinal membranes (usually as sequelae of proliferative sickle retinopathy). Retinal detachment is the most severe complication (Stage V) of proliferative sickle retinopathy." ; obo:SCDO_0000303 "We provided a more SCD specific description than the generic descriptions provided in existing ontologies." ; obo:SCDO_0000340 "Ballas et al 2010 Am J Hematol" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; a owl:Class ; rdfs:label "Retinal Detachment" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C101217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C75583 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001010 obo:IAO_0000115 "Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012189" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001010" ; oboInOwl:hasDbXref "MESH:D012189" ; oboInOwl:hasExactSynonym "Retrospective Study" ; a owl:Class ; rdfs:label "Retrospective Studies" ; rdfs:subClassOf obo:SCDO_0000263 . obo:SCDO_0001017 obo:IAO_0000115 "An open swath of land that has few homes or other buildings, and not very many people." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Rural", "Rural Area", "Rural Setting" ; a owl:Class ; rdfs:label "Rural Location" ; rdfs:subClassOf obo:GAZ_00000448, obo:SCDO_0000496 . obo:SCDO_0001019 obo:IAO_0000115 "Round or oval-shaped intraretinal accumulation of erythrocytes that may be up to 2 mm in diameter. This small intraretinal hematoma is initially red and becomes salmon colored with time." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "Ballas et al 2010 Am J Hematol" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Salmon Patch Hemorrhages" ; a owl:Class ; rdfs:label "Salmon Patch Hemorrhage" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C75583 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0001020 obo:IAO_0000115 "Studies in which a number of subjects are selected from all subjects in a defined population. Conclusions based on sample results may be attributed only to the population sampled." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012494" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001020" ; oboInOwl:hasDbXref "MESH:D012494" ; oboInOwl:hasExactSynonym "Probability Sample", "Probability Samples", "Sampling Study" ; a owl:Class ; rdfs:label "Sampling Studies" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0001023 obo:IAO_0000115 "Pain resulting from the presence of Sickle Cell Disease (SCD). Such pain can be acute, chronic or a mixture of the two." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "Okpala I., Tawil A. Management of pain in sickle-cell disease. Journal of the Royal Society of Medicine. 2002;95(9):456-458. doi: 10.1258/jrsm.95.9.456" ; oboInOwl:hasExactSynonym "SCD Pain", "SCD-Related Pain" ; a owl:Class ; rdfs:label "SCD Related Pain" ; rdfs:subClassOf obo:SCDO_0000851, obo:SCDO_0000895, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000952 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_1000106 ] . obo:SCDO_0001025 obo:IAO_0000115 "An operation for retinal detachment which reduces the size of the globe by indenting the sclera so that it approximates the retina." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012591" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001025" ; oboInOwl:hasDbXref "MESH:D012591" ; oboInOwl:hasExactSynonym "Scleral Buckle Surgery", "Scleral Bucklings" ; a owl:Class ; rdfs:label "Scleral Buckling" ; rdfs:subClassOf obo:SCDO_0000833 . obo:SCDO_0001027 obo:IAO_0000115 "Specialized healthcare delivered as a follow-up or referral from a primary care provider." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D063127" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001027" ; oboInOwl:hasDbXref "MESH:D063127" ; oboInOwl:hasExactSynonym "Secondary Care", "Secondary Health Care" ; a owl:Class ; rdfs:label "Secondary Healthcare" ; rdfs:subClassOf obo:SCDO_0000494 . obo:SCDO_0001029 obo:IAO_0000115 "Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D057185" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001029" ; oboInOwl:hasDbXref "MESH:D057185" ; a owl:Class ; rdfs:label "Sedentary Lifestyle" ; rdfs:subClassOf obo:SCDO_0000689 . obo:SCDO_0001033 obo:IAO_0000115 "A relation between a selected entity and the predefined criteria that were met by the entity and that made it eligible for selection." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. Should be restricted to all measure/questionnaire classes.""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "selection criteria met" . obo:SCDO_0001034 obo:IAO_0000115 "Caring for self when ill or positive actions and adopting behaviors to prevent illness." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012648" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001034" ; oboInOwl:hasDbXref "MESH:D012648" ; oboInOwl:hasExactSynonym "Self Management", "Self-Care", "Self-Management" ; a owl:Class ; rdfs:label "Self Care" ; rdfs:subClassOf obo:SCDO_0000978 . obo:SCDO_0001035 obo:IAO_0000115 "Cognitive mechanism based on expectations or beliefs about one's ability to perform actions necessary to produce a given effect." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001035" ; oboInOwl:hasDbXref "MESH:D020377" ; oboInOwl:hasExactSynonym "Self-Concept" ; a owl:Class ; rdfs:label "Self Efficacy" ; rdfs:subClassOf obo:SCDO_0000286 . obo:SCDO_0001037 obo:IAO_0000115 "The weight in kilograms or pounds as reported by the participant." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Self-Reported Weight" ; rdfs:subClassOf obo:SCDO_0000152 . obo:SCDO_0001041 obo:IAO_0000115 "Epidemiologic studies based on the detection through serological testing of characteristic change in the serum level of specific antibodies. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016036" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001041" ; oboInOwl:hasDbXref "MESH:D016036" ; oboInOwl:hasExactSynonym "Seroprevalences" ; a owl:Class ; rdfs:label "Seroepidemiologic Studies" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0001043 obo:IAO_0000115 "The amount of the HDL cholesterol, the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion, in a specified volume of serum." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 obo:VT_0000184 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Blood HDL Cholesterol Amount", "Blood High Density Lipoprotein Cholesterol Amount", "Circulating HDL Cholesterol Amount", "Circulating HDL Cholesterol Level", "HDL Cholesterol Level", "HDL Level" ; a owl:Class ; rdfs:label "Serum HDL Cholesterol Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000315 ] . obo:SCDO_0001044 obo:IAO_0000115 "A 36-item instrument for measuring health status and outcomes via patient self-report. It is designed for use in surveys of general and specific populations, health policy evaluations, and clinical practice and research. The SF-36v2 measures the following eight health concepts, which are relevant across age, disease, and treatment groups: physical functioning, role limitations due to physical health problems, bodily pain, general health, vitality (energy/fatigue), social functioning, role limitations due to emotional problems, and mental health (psychological distress and psychological well-being). Both standard (4-week) and acute (1-week) recall versions are available. The survey's standardized scoring system yields a profile of eight health scores and two summary measures (physical and mental health) and a self-evaluated change in health status." ; obo:SCDO_0000303 "Add these annotation properties: -- has cross-cultural adaptation -- freely available -- has translations", "Suggest update to label in PhenX (from \"Physical, Social, and Mental Health Functioning (SF-36V2)\")" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: #191201" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Healthy people; Clinic patients" ; obo:SCDO_0001033 "Demonstrated validity with SCD populations; multiple publications using the measure in SCD; very widely used with healthy populations and those with chronic conditions" ; obo:SCDO_0001222 "Adults 18 years and older" ; obo:SCDO_1000288 "Suggest update to label" ; a owl:Class ; rdfs:label "SF-36v2 Health Survey" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0001047 obo:IAO_0000115 "A measure of stigma among adults living with Sickle Cell disease. Focus on; depressive symptoms, pain, assertive communication, satisfaction with pain management experience, and health-related stigma." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Research or Clinical Assessment Tool\". Add these annotation properties: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations""" ; obo:SCDO_0000340 "Jenerette C, Brewer CA, Crandell J, Ataga KI. Preliminary validity and reliability of the Sickle Cell Disease Health-Related Stigma Scale.Issues Ment Health Nurs.2012 Jun;33(6):363-9." ; obo:SCDO_1000288 "None" ; dc:source "Jenerette C, Brewer CA, Crandell J, Ataga KI. Preliminary validity and reliability of the Sickle Cell Disease Health-Related Stigma Scale.Issues Ment Health Nurs.2012 Jun;33(6):363-9." ; oboInOwl:hasExactSynonym "SCD-HRSS", "Sickle Cell Disease Health-Related Stigma Scale" ; a owl:Class ; rdfs:label "Sickle Cell Disease Health-Related Stigma Scale (SCD-HRSS)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0001048 obo:IAO_0000115 "The SCPBI-Y is a brief clinical interview designed to assess pain burden for children and adolescents with SCD." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Research or Clinical Assessment Tool\". Add these annotation properties: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations""" ; obo:SCDO_0000340 "Zempsky WT, O'Hara EA, Santanelli JP, Palermo TM, New T, Smith-Whitley K, Casella JF. Validation of the sickle cell disease pain burden interview-youth. J Pain. 2013 Sep;14(9):975-82." ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "SCPBI-Y" ; a owl:Class ; rdfs:label "Sickle Cell Disease Pain Burden Interview - Youth" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0001049 obo:IAO_0000115 "Sickle cell tests are used to help diagnose sickle cell anemia (also called sickle cell disease) and to identify those who may have sickle cell trait. Sickle cell anemia is an inherited disorder that leads to the production of an abnormal hemoglobin called hemoglobin S (Hb S or Hgb S). Sickle cell tests determine the presence and relative amount of hemoglobin S in a blood sample." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "https://labtestsonline.org/tests/sickle-cell-tests" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Screening for Sickle Cell Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease Screening Test" ; rdfs:subClassOf obo:SCDO_0000781 . obo:SCDO_0001050 obo:IAO_0000115 "A nine-item self-administered questionnaire that measures disease-specific perceptions of the ability to manage day-to-day issues resulting from sickle cell disease (SCD). Items are scores according to a five-point scale ranging from 1 - Not sure at all to 5 - Very sure. Responses from individual items are summed to give an overall score with higher scores indicating greater self-efficacy." ; obo:SCDO_0000303 "Suggest update to label in PhenX as we have done." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Self-efficacy in Sickle Cell Disease #820401" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Clinic Patients (Adults with SCD)" ; obo:SCDO_0000486 "Self-efficacy, or one’s perceptions that they can exercise control over their behaviors and environment, may play an important role in determining the ability to adjust to chronic conditions such as sickle cell disease (SCD)." ; obo:SCDO_0001222 "18 and older" ; obo:SCDO_1000288 "Suggest update to label" ; dc:source ; oboInOwl:hasExactSynonym "Scale of Self-efficacy in Sickle Cell Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease Self-Efficacy Scale" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0001051 obo:IAO_0000115 "A variant form of sickle cell disease that results from inheriting the sickle mutation in combination with another beta-globin gene mutation. These hemoglobinopathies may have different clinical severity compared to the homozygous form of sickle cell disease (HbSS)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.uptodate.com/contents/overview-of-variant-sickle-cell-syndromes" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "SCD Variant", "Sickle Cell Disease Variant", "Variant Sickle Cell Syndromes" ; a owl:Class ; rdfs:label "Variant Sickle Cell Syndrome" ; rdfs:subClassOf obo:SCDO_1000106, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ] . obo:SCDO_0001052 obo:IAO_0000115 "A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing sickle cell related pain." ; obo:SCDO_0000303 "Request inclusion into MESH below \"Pain Management\"." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D059408" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Sickle Cell Pain Managements" ; a owl:Class ; rdfs:label "Sickle Cell Pain Management" ; rdfs:subClassOf obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000952 ] . obo:SCDO_0001053 obo:IAO_0000115 "Pain lasting at least two hours that requires an unscheduled emergency room visit or hospitalization or that disrupts daily activities." ; obo:SCDO_0000303 "Could be categorised as a phenotype \"Finding\".", "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=830101" ; oboInOwl:hasExactSynonym "Pain Episode", "Painful Crisis", "Painful Event", "Sickle Cell Acute Pain Episode", "Sickle Cell Pain Episode" ; a owl:Class ; rdfs:label "Sickle Cell Painful Event" ; rdfs:subClassOf obo:SCDO_0001023 . obo:SCDO_0001054 obo:IAO_0000115 "A cancer that is almost exclusively associated with sickle cell trait and/or sickle cell disease." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:source "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Sickle Cell Associated Cancer" ; a owl:Class ; rdfs:label "Sickle Cell Related Cancer" ; rdfs:subClassOf obo:OBI_1110053 . obo:SCDO_0001055 obo:IAO_0000115 "The condition of being heterozygous for hemoglobin S." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012805" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001055" ; oboInOwl:hasDbXref "MESH:D012805" ; oboInOwl:hasExactSynonym "AS Genotype", "Haemoglobin Genotype AS", "Hemoglobin Genotype AS" ; a owl:Class ; rdfs:label "Sickle Cell Trait" ; rdfs:subClassOf obo:NCIT_C95534, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000469 ; owl:someValuesFrom obo:SCDO_0000322 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000161 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0003158 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:MP_0013305 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000508 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0001511 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0002106 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0009445 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0004139 ] . obo:SCDO_0001056 obo:IAO_0000115 "A mild form of sickle cell thalassemia characterized by the presence of hemoglobin S and a reduced amount of hemoglobin A in the red blood cells. It is characterized by the presence of small red blood cells and mild anemia." ; obo:SCDO_0000303 "Suggest update to label in NCIT from \"Sickle Beta Plus Thalassemia\" to \"Sickle Beta Minus Thalassemia\"" ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98837" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C98837" ; oboInOwl:hasExactSynonym "S beta-minus", "Sickle B- Thalassemia", "Sickle Beta Minus Thalassemia", "Sickle Cell Disease-S Beta Minus Thalassemia", "Sickle Cell-B- Thalassemia", "Sickle Cell-Beta Minus Thalassemia" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S Beta Minus Thalassemia" ; rdfs:subClassOf obo:NCIT_C95539, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C561 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000010 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000159 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001765 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0001111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0002106 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0006905 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0009350 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:HP_0011906 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000976 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0001059 obo:IAO_0000115 "One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006450" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001059" ; oboInOwl:hasDbXref "MESH:D006450" ; oboInOwl:hasExactSynonym "Hb SC-disease", "Hemoglobin S / Hemoglobin C Disease", "Hemoglobin SC Disease", "SC Disease", "Sickle Cell Disease SC", "Sickle Cell Hemoglobin C Disease", "Sickle Cell-Haemoglobin C Disease", "Sickle Cell-Hemoglobin C Disease", "Sickle-Cell/Hb-C Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-SC" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000163, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000469 ; owl:someValuesFrom obo:SCDO_0000316 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000513 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0001061 obo:IAO_0000115 "A rare compound heterozygous hemoglobinopathy characterised by the presence of two beta globin gene variants: that of hemoglobin S (beta-6(GAG-->GTG)) and that of hemoglobin D-Punjab (beta-121(GAA-->CAA))." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. Perhaps as sub-class of \"Sickle Cell-Hemoglobin D Disease\" in the NCIT." ; obo:SCDO_0000340 "Rahimah Ahmad*, Syahira Lazira Omar*, Siti Hida H M Arif*, Faidatul Syazlin A Hamid*, Nur Aisyah Aziz*, Nik Hafidzah N Mustapha**, Zubaidah Zakaria*Haemoglobin Sickle D Punjab: - A Case Report. Med J Malaysia. 2014. Vol 69 No 1." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasExactSynonym "Haemoglobin S/D-Punjab", "Hemoglobin S/D-Punjab", "Sickle Cell-Haemoglobin D-Punjab", "Sickle Cell-Hemoglobin D-Punjab Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S/D-Punjab" ; rdfs:subClassOf obo:NCIT_C155310, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000528 ] . obo:SCDO_0001062 obo:IAO_0000115 "A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin E mutations, which can cause mild hemolytic anemia." ; obo:SCDO_0000303 "Suggest update to description of \"Sickle Cell-Hemoglobin D Disease\" in the NCIT." ; obo:SCDO_0000340 "http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-S-E" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasExactSynonym "Hb SE-Disease", "Hemoglobin SE Disease", "Hemoglobin SE-Disease", "Sickle Cell Disease SE", "Sickle Cell-Haemoglobin E Disease", "Sickle Cell-Hemoglobin E Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-SE" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000163, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000052 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0010885 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C35447 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000508 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0000851 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0001067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0002106 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:SCDO_0009350 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000009 ] . obo:SCDO_0001063 obo:IAO_0000115 "Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three Hb Lepore variants described in association with HbS." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "SCD-S/Lepore Boston", "Sickle Cell Disease-S/Lepore", "Sickle Cell-Hb Lepore Boston Syndrome", "Sickle Cell-Hemoglobin Lepore Boston Syndrome" ; a owl:Class ; rdfs:comment "Hb Lepore Washington, also known as Hb Lepore Boston or Hb Lepore Washington-Boston; most common in Italians from Southern Italy." ; rdfs:label "Sickle Cell Disease-S/Lepore Boston" ; rdfs:subClassOf obo:NCIT_C95539, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000070 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000089 ] . obo:SCDO_0001064 obo:IAO_0000115 "One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin O-Arab. It can cause anemia, repeated infections, and periodic episodes of pain and organ damage." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-S-O-Arab" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasExactSynonym "Hb F,S,O-Arab", "Hb S O-Arab disease", "Hb S,O-Arab", "Hemoglobin S O-Arab Disease", "SO(Arab) disease", "Sickle Cell-Haemoglobin O-Arab Disease", "Sickle Cell-Hemoglobin O-Arab Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S/O-Arab" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000163, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000424 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000051 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000040 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000016 ] . obo:SCDO_0001065 obo:IAO_0000115 "'A variant of sickle cell disease in which individuals have atypical hemoglobin molecules called hemoglobin S together with another form of abnormal hemoglobin, other than hemoglobin C,D,E and O-Arab. [Curator team: []]'" ; obo:SCDO_0000340 "http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-S-and-other-than-A-C-D-E-O-Arab" ; oboInOwl:hasExactSynonym "Hb S Other than A,C,D,E,O-Arab" ; a owl:Class ; rdfs:label "obsolete Sickle Cell-Hemoglobin Other than A,C,D,E,O-Arab" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001067 obo:IAO_0000115 "Retinal changes of sickle cell disease that can be either proliferative or non-proliferative. In both cases, the changes are caused by erythrostasis secondary to sickling." ; obo:SCDO_0000303 """Request inclusion into HPO below \"Retinopathy\". Use the scielo source to add info on diagnosis and treatment.""" ; obo:SCDO_0000340 "Bonanomi et al 2013 Arq Bras Oftalmol" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Retinopathy due to SCD", "Sickle Cell Retinopathy" ; a owl:Class ; rdfs:label "Sickle Retinopathy" ; rdfs:subClassOf obo:HP_0000478, obo:NCIT_C115319, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0008623 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0001068 obo:IAO_0000115 "A qualitative screening test for sickling haemoglobins, especially HbS. In the SCT, sodium metabisulfite or sodium dithionate is used to desolubilise haemoglobin S to the crystallised deoxygenated form, which causes the abnormal RBCs to sickle, as detected by light microscopy." ; obo:SCDO_0000303 "In SNOMED CT this term seems to be both \"Sickle cell identification, slide method\" and \"Sickling Test\". Request they merge these terms?" ; obo:SCDO_0000340 "Segen's Medical Dictionary. © 2012 Farlex, Inc." ; obo:SCDO_1000288 "Few but definitions not freely available." ; oboInOwl:hasExactSynonym "Sickle Cell Identification, Slide Method" ; a owl:Class ; rdfs:label "Sickling Test" ; rdfs:subClassOf obo:SCDO_0000548, obo:SCDO_1000577 . obo:SCDO_0001069 obo:IAO_0000115 "A generic measure used to evaluate the impact of SCD on both physical and emotional functioning of an affected person. SIP is designed to measure perceived health status and to be used as an outcome measure for evaluation, program planning, and policy formation related to health care. It is designed in such a way as to reflect sensitivity to changes and/or differences in health status and to be applicable across a broad range of types and severities of the SCD illness, as well as different demographic and cultural groups." ; obo:SCDO_0000303 """Too specific to SCD to be included in other ontologies. These annotation properties still required: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations""" ; obo:SCDO_0000340 "http://link.springer.com/referenceworkentry/10.1007%2F978-0-387-79948-3_1833", "http://qol.thoracic.org/sections/instruments/pt/pages/sick.html" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; dc:source "Bergner M., Bobbitt R.A., Carter W.B. and Gilson B.S. (1981). The Sickness Impact Profile: development and final revision of a health status measure. Medical Care 19,787-805." ; oboInOwl:hasExactSynonym "SIP", "Sickness Impact Profile" ; a owl:Class ; rdfs:label "Sickness Impact Profile (SIP)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0001070 obo:IAO_0000115 "'The bodily system consisting of the skin and its associated structures, such as the hair, nails, sweat glands, and sebaceous glands. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0008348 ; obo:SCDO_0000340 "integumentary system. (n.d.) The American Heritage Medical Dictionary. (2007). Retrieved December 14 2016" ; oboInOwl:hasExactSynonym "Dermatologic System", "Integumentary System" ; a owl:Class ; rdfs:label "deprecated Skin" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001073 obo:IAO_0000115 "An abnormal change in skin color, appearance, or texture." ; obo:SCDO_0000303 "Suggest update to description in HPO." ; obo:SCDO_0000340 obo:HP_0000988 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0000988" ; oboInOwl:hasExactSynonym "Exanthem" ; a owl:Class ; rdfs:label "Skin Rash" ; rdfs:subClassOf obo:HP_0011122, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C258 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000066 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0001075 obo:IAO_0000115 "An intrinsic sleep disorder characterized by breathing abnormalities." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NBO_0000494" ; obo:SCDO_1000288 "Suffcient" ; oboInOwl:hasDbXref "NBO:0000494" ; oboInOwl:hasExactSynonym "SBD" ; a owl:Class ; rdfs:label "Sleep Breathing Disorder" ; rdfs:subClassOf obo:HP_0000708, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001076 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_1000338 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001076 obo:IAO_0000115 "An interviewer-administered questionnaire which captures routine sleep schedule, sleep deprivation, morningness-eveningness, insomnia, narcolepsy, cataplexy and associated distress." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Suggest update to label\") as we have done." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Sleep Disorders Screener #121001" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:121001" ; oboInOwl:hasExactSynonym "National Institute of Mental Health (NIMH) Sleep Patterns and Problems Instrument" ; a owl:Class ; rdfs:label "Sleep Disorders Screener - Adult" ; rdfs:subClassOf obo:SCDO_1000348 . obo:SCDO_0001077 obo:IAO_0000115 "A microscope with a light source that can be projected into a linear beam. It allows cross-sectional viewing of the aqueous humor; conjuncteiva; cornea; eyelids; iris; and lens of the eye." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D066167" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001077" ; oboInOwl:hasDbXref "MESH:D066167" ; a owl:Class ; rdfs:label "Slit Lamp" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:NCIT_C75583 ] . obo:SCDO_0001079 obo:IAO_0000115 "Inhaling and exhaling the smoke of burning tobacco (Cigar, Cigarette, Hookah, Pipe, Smoking, Waterpipe)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012907" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001079" ; oboInOwl:hasDbXref "MESH:D012907" ; a owl:Class ; rdfs:label "Smoking" ; rdfs:subClassOf obo:SCDO_0000487 . obo:SCDO_0001080 obo:IAO_0000115 "Discontinuing the habit of smoking." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016540" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001080" ; oboInOwl:hasDbXref "MESH:D016540" ; oboInOwl:hasExactSynonym "Quit Smoking" ; a owl:Class ; rdfs:label "Smoking Cessation" ; rdfs:subClassOf obo:SCDO_0001159 . obo:SCDO_0001082 obo:IAO_0000115 "The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012931" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001082" ; oboInOwl:hasDbXref "MESH:D012931" ; oboInOwl:hasExactSynonym "Social Ecology" ; a owl:Class ; rdfs:label "Social Environment" ; rdfs:subClassOf obo:SCDO_0000435 . obo:SCDO_0001083 obo:IAO_0000115 "Social functioning defines an individual's interactions with their environment and the ability to fulfill their role within such environments as work, social activities, and relationships with partners and family." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Include terms for social relationships; social activities?""" ; obo:SCDO_0000340 "Compr Psychiatry. 2000 Jan-Feb;41(1):63-9. Assessment of social functioning in depression." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "PROMIS Domain Frameworks/Definitions nih.promis.org" ; a owl:Class ; rdfs:label "Social Functioning" ; rdfs:subClassOf obo:NCIT_C17047 . obo:SCDO_0001084 obo:IAO_0000115 "The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012934" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001084" ; oboInOwl:hasDbXref "MESH:D012934" ; oboInOwl:hasExactSynonym "Social Isolations" ; a owl:Class ; rdfs:label "Social Isolation" ; rdfs:subClassOf obo:SCDO_0001083 . obo:SCDO_0001085 obo:IAO_0000115 "A role that is ascribed to individuals in a community." ; obo:SCDO_0000340 "http://semanticscience.org/resource/SIO_000676" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001085" ; oboInOwl:hasDbXref "SIO:000676" ; oboInOwl:hasExactSynonym "Social Function" ; a owl:Class ; rdfs:label "Social Role" ; rdfs:subClassOf obo:SCDO_0001083 . obo:SCDO_0001086 obo:IAO_0000115 "An extent/ degree to which an individual fulfills the expectations of his/her social role." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Social Role Fulfillment" ; rdfs:subClassOf obo:SCDO_0001083 . obo:SCDO_0001087 obo:IAO_0000115 "The personal set of abilities required to successfully interact and communicate with others, both verbally and non-verbally through gestures, body language and personal appearance." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D066107" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001087" ; oboInOwl:hasDbXref "MESH:D066107" ; oboInOwl:hasExactSynonym "Interpersonal Skill", "Social Ability", "Social Competence", "Social Skills" ; a owl:Class ; rdfs:label "Social Skill" ; rdfs:subClassOf obo:SCDO_0001083 . obo:SCDO_0001088 obo:IAO_0000115 "Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012944" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001088" ; oboInOwl:hasDbXref "MESH:D012944" ; oboInOwl:hasExactSynonym "Psychosocial Support System", "Social Network" ; a owl:Class ; rdfs:label "Social Support" ; rdfs:subClassOf obo:SCDO_0001083 . obo:SCDO_0001089 obo:IAO_0000115 "Abstract standards or empirical variables in social life which are believed to be important and/or desirable." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012945" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001089" ; oboInOwl:hasDbXref "MESH:D012945" ; oboInOwl:hasExactSynonym "Value Orientation", "Value Orientations" ; a owl:Class ; rdfs:label "Social Values" ; rdfs:subClassOf obo:SCDO_0000299 . obo:SCDO_0001090 obo:IAO_0000115 "Social and economic factors that characterize the individual or group within the social structure." ; obo:SCDO_0000303 "Maybe include some sub-classes of this term in MESH? There would be overlap with terms in QOL, so would need to work around that." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012959" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001090" ; oboInOwl:hasDbXref "MESH:D012959" ; a owl:Class ; rdfs:label "Socioeconomic Factors" ; rdfs:subClassOf obo:SCDO_0001082 . obo:SCDO_0001091 obo:IAO_0000115 "The combination of one's social class and income level. Includes socioeconomic differences between individuals or groups." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/APAONTO/?p=classes&conceptid=http%3A%2F%2Fontology.apa.org%2Fapaonto%2FtermsonlyOUT%2520%285%29.owl%23Socioeconomic_Status" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001091" ; oboInOwl:hasDbXref "APAONTO:Socioeconomic_Status" ; a owl:Class ; rdfs:label "Socioeconomic Status" ; rdfs:subClassOf obo:SCDO_0001090 . obo:SCDO_0001092 obo:IAO_0000115 "A basic first line test that looks for the presence of abnormal Hemoglobin S in a blood sample. Sodium metabisulfite is added to the blood sample which causes Hb S polymerisation and sickling of red blood cells if Hb S is present. A positive result means that a person has either Sickle Cell Disease or Sickle Cell Trait. Confirmatory tests are needed to distinguish which form of SCD the patient has." ; obo:SCDO_0000303 """In SNOMED CT this term is \"Hemoglobin S Solubility Test\" Commonly used tests include hemoglobin electrophoresis, isoelectric focusing (IEF), high performance liquid chromatography (HPLC), and DNA analysis.""" ; obo:SCDO_1000288 "Few but definitions not freely available." ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Hemoglobin S Solubility Test" ; a owl:Class ; rdfs:label "Solubility Test" ; rdfs:subClassOf obo:SCDO_0000548, obo:SCDO_1000577 . obo:SCDO_0001097 obo:IAO_0000115 "Instruments for measuring arterial blood pressure consisting of an inflatable cuff, inflating bulb, and a gauge showing the blood pressure." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D019722" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001097" ; oboInOwl:hasDbXref "MESH:D019722" ; a owl:Class ; rdfs:label "Sphygmomanometer" ; rdfs:subClassOf obo:SCDO_0000710 . obo:SCDO_0001098 obo:IAO_0000115 "Sensitivity or attachment to religious values, or to things of the spirit as opposed to material or worldly interests." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D029181" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001098" ; oboInOwl:hasDbXref "MESH:D029181" ; oboInOwl:hasExactSynonym "Spiritual Beliefs", "Spiritualities" ; a owl:Class ; rdfs:label "Spirituality" ; rdfs:subClassOf obo:SCDO_0000299 . obo:SCDO_0001099 obo:IAO_0000115 "A spirometer is an apparatus for measuring the volume of air inspired and expired by the lungs. It is a precision differential pressure transducer for the measurements of respiration flow rates. The spirometer records the amount of air and the rate of air that is breathed in and out over a specified period of time." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0000452" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001099" ; oboInOwl:hasDbXref "ERO:0000452" ; a owl:Class ; rdfs:label "Spirometer" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000474 ; owl:someValuesFrom obo:SCDO_0000704 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:NCIT_C85397 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000705 ] . obo:SCDO_0001105 obo:IAO_0000115 "A form of nephrotic syndrome that does not respond to treatment with steroid medication after 8 weeks, specifically in children." ; obo:SCDO_0000303 """Suggest update to description in HPO Provide source for additional info.""" ; obo:SCDO_0000340 obo:HP_0012588 ; obo:SCDO_0000661 "May represent underlying focal segmental glomerulosclerosis, minimal change disease, or other underlying cause. Can be subseqeunt to known mutations." ; obo:SCDO_0000662 "Persistence of nephrotic syndrome despite appropriate treatment with corticosteroids." ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0012588" ; a owl:Class ; rdfs:label "Steroid-Resistant Nephrotic Syndrome" ; rdfs:subClassOf obo:SCDO_0000796, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000219 ; owl:someValuesFrom obo:SCDO_0000796 ] . obo:SCDO_0001107 obo:IAO_0000115 "A perceived attribute that is deeply discrediting and is considered to be a violation of social norms." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D057545" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001107" ; oboInOwl:hasDbXref "MESH:D057545" ; oboInOwl:hasExactSynonym "Social Stigma", "Social Stigmas", "Stigmas" ; a owl:Class ; rdfs:label "Stigma" ; rdfs:subClassOf obo:NCIT_C17047 . obo:SCDO_0001108 obo:IAO_0000115 "An oversimplified perception or conception, especially or persons, social groups, etc." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D013240" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001108" ; oboInOwl:hasDbXref "MESH:D013240" ; oboInOwl:hasExactSynonym "Stereotyping" ; a owl:Class ; rdfs:label "Stigmatization" ; rdfs:subClassOf obo:NCIT_C17047 . obo:SCDO_0001111 obo:IAO_0000115 "A group of pathological conditions characterized by sudden loss of neurological function due to brain ischemia or intracranial hemorrhages. Stroke is classified by the type of tissue necrosis, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature." ; obo:SCDO_0000303 "Types of stroke relevant to SCD to be added as children of this class." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D020521" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001111" ; oboInOwl:hasDbXref "MESH:D020521" ; oboInOwl:hasExactSynonym "Brain Vascular Accident", "CVA", "Cerebral Infarction", "Cerebral Vascular Event", "Cerebrovascular Accident", "Cerebrovascular Stroke" ; a owl:Class ; rdfs:label "Stroke" ; rdfs:subClassOf obo:SCDO_0000954, obo:SCDO_1000037, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0001166 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0001112 obo:IAO_0000115 "This measure is a physical assessment to determine neurological deficits due to a stroke." ; obo:SCDO_0000303 "Suggest update to label in PhenX" ; obo:SCDO_0000340 ; obo:SCDO_0000486 "This measure is used to describe the consequences of a stroke and to monitor the effects of treatment and recovery." ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:820800" ; oboInOwl:hasExactSynonym "Stroke Impact/Outcome Measure", "Stroke Outcome Measure" ; a owl:Class ; rdfs:label "Stroke Impact Measure" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0001113 obo:IAO_0000115 "This questionnaire includes 59 proxy- or self-report items in 8 domains that assess multidimensional stroke outcomes in adults." ; obo:SCDO_0000303 "Suggest update to description in PhenX." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820701" ; obo:SCDO_0000479 "PhenX protocol: Stroke Impact Scale (SIS) - Adults #820701" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "phenX:820701" ; oboInOwl:hasExactSynonym "Stroke Impact Scale (SIS) - Adults" ; a owl:Class ; rdfs:label "Stroke Impact Scale (SIS)" ; rdfs:subClassOf obo:SCDO_0001339, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0001114 obo:IAO_0000115 "A clinical test to measure the blood flow velocities in intracranial arteries. Elevated intracranial arterial blood flow rates are indicative of expanding vessel lesions and a subsequent increased risk of stroke." ; obo:SCDO_0000303 "Include below \"Cerebral Flow Test\"? -- Include below \"Vascular Endothelial Function Test\"?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001114" ; oboInOwl:hasDbXref "phenX:821001" ; a owl:Class ; rdfs:label "Stroke Risk Test in Children with Sickle Cell Disease" ; rdfs:subClassOf obo:NCIT_C154865, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0000396 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:NCIT_C173396 ] . obo:SCDO_0001117 obo:IAO_0000115 "The occurrence of multiple self-limited episodes of unwanted, often painful erections lasting <4 hours." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps below \"Priapism\" in MESH." ; obo:SCDO_0000340 "Evidence-Based Management of Sickle Cell Disease, Expert Panel Report, 2014" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Recurrent Priapism" ; a owl:Class ; rdfs:label "Stuttering Priapism" ; rdfs:subClassOf obo:SCDO_0000923, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001120 obo:IAO_0000115 "Assessment with the goal to obtain a relevant drug and alcohol history and perform a physical examination in order to establish whether there is a diagnosis of a substance use disorder." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; a owl:Class ; rdfs:comment "If substance use disorder diagnosed, the patient’s readiness to change should be categorized and information from the assessment should be used to formulate a management plan based on the individual’s needs." ; rdfs:label "Substance Use History" ; rdfs:subClassOf obo:NCIT_C18772 . obo:SCDO_0001121 obo:IAO_0000115 "An indication of whether the respondent has ever used a drug during his or her entire life." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Substances - Lifetime Use" ; rdfs:subClassOf obo:SCDO_0001120, obo:SCDO_1000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000337 ] . obo:SCDO_0001122 obo:IAO_0000115 "Frequent thinking about or preoccupation with killing oneself." ; obo:SCDO_0000303 "Suggest update to description in HPO (correct typo in \"oneself\")" ; obo:SCDO_0000340 obo:HP_0031589 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0031589" ; oboInOwl:hasExactSynonym "Suicidal Ideation" ; a owl:Class ; rdfs:label "Suicidal Thoughts" ; rdfs:subClassOf obo:SCDO_0000360, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0001123 obo:IAO_0000115 "Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012657" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001123" ; oboInOwl:hasDbXref "MESH:D012657" ; oboInOwl:hasExactSynonym "Self Help Group", "Self-Help Group", "Self-Help Groups", "Therapeutic Social Club" ; a owl:Class ; rdfs:label "Support Group" ; rdfs:subClassOf obo:SCDO_0001083 . obo:SCDO_0001129 obo:IAO_0000115 "Measures aimed at providing appropriate supportive and rehabilitative services to minimize morbidity and maximize quality of life after a long-term disease or injury is present." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D055512" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001129" ; oboInOwl:hasDbXref "MESH:D055512" ; oboInOwl:hasExactSynonym "Supportive Therapy", "Tertiary Prevention" ; a owl:Class ; rdfs:label "Supportive Therapeutics" ; rdfs:subClassOf obo:SCDO_0001152, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001919 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002913 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003198 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003641 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0008682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0009045 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C26702 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000032 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000984 ] . obo:SCDO_0001132 obo:IAO_0000115 "A computerized test for the assessment of visual attention problems in individuals ages 8 years old and older." ; obo:SCDO_0000303 "Suggest update to label in PhenX as we have done." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=821201" ; obo:SCDO_0000479 "PhenX protocol: Sustained and Selective Attention #821201" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:821201" ; oboInOwl:hasExactSynonym "Conners CPT 3", "Conners Continuous Performance Test 3rd Edition", "Conners Continuous Performance Test 3rd Edition (Conners CPT 3)" ; a owl:Class ; rdfs:label "Sustained and Selective Attention Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0001133 obo:IAO_0000115 "Therapeutics that ease the symptoms without addressing the basic cause of the disease." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.medicinenet.com/script/main/art.asp?articlekey=10701" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Symptomatic Treatment" ; a owl:Class ; rdfs:label "Symptomatic Therapeutics" ; rdfs:subClassOf obo:SCDO_0001152, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000021 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000032 ] . obo:SCDO_0001135 obo:IAO_0000115 "Refers to a worsening, over a short period of time, of the symptoms and signs of SCD; usually associated with pain and/or shortage of blood (anaemia). Can be suspected in a person with sickle cell disease who presents with a sudden onset of pain, infection, anemia or other symptoms such as stroke or priapism. Acute pain frequently occurs spontaneously, but may be precipitated by infections, skin cooling, dehydration or stress." ; obo:SCDO_0000303 "Request inclusion into relevant ontology", "This is a difficult one to describe, as I think it can also be referred to as an 'acute painful crisis' (this is not clear from the literature). Have tried to merge descriptions from different sources - please review." ; obo:SCDO_0000340 , "Rees, D. C., Olujohungbe, A. D., Parker, N. E., Stephens, A. D., Telfer, P. and Wright, J. (2003), Guidelines for the management of the acute painful crisis in sickle cell disease. British Journal of Haematology, 120: 744-752. doi:10.1046/j.1365-2141.2003.04193.x", "SCD Management guidelines - Nigeria" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Acute Sickle Cell Crisis" ; rdfs:subClassOf obo:SCDO_0000895, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0008623 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0001136 obo:IAO_0000115 "'Affecting a number of tissues relating to the entire organism as distinguished from and of its individual parts. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000269 ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/systemic" ; a owl:Class ; rdfs:label "deprecated Systemic" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001139 obo:IAO_0000115 "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the temporal pattern of the phenotype. Temporal pattern is defined as \"The speed at which disease manifestations appear and develop.\" (HPO)" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "temporal pattern modified by" ; rdfs:subPropertyOf obo:SCDO_1000005 . obo:SCDO_0001140 obo:IAO_0000115 "Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D063128" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001140" ; oboInOwl:hasDbXref "MESH:D063128" ; oboInOwl:hasExactSynonym "Tertiary Care", "Tertiary Health Care" ; a owl:Class ; rdfs:label "Tertiary Healthcare" ; rdfs:subClassOf obo:SCDO_0000494 . obo:SCDO_0001141 obo:IAO_0000115 "The Test of Functional Health Literacy Assessment (TOFHLA) assesses a patient's level of comprehension of health-related material. It is available in a full-format (a 22-minute test, with 50 reading comprehension items in three passages and 17 numeracy items), an abbreviated format (a 12-minute test, with 36 reading comprehension items in two passages and four numeracy items) and a shortened version (the S-TOFHLA, a 7-minute test, with 36 reading comprehension items in 2 passages.). The passages on the S-TOFHLA use a modified Cloze procedure where every fifth to seventh word is omitted and subjects select the correct word from among a set of four options. The passages contain information about an upper gastrointestinal tract x-ray procedure, and the \"Rights and Responsibilities\" section from a Medicaid application, and have Gunning-Fox readability indices of fourth and tenth grade, respectively. In early developmental studies, the reading comprehension passages in the S-TOFHLA had a reliability coefficient (Cronbach's alpha) of 0.97 and correlation with the Rapid Estimate of Adult Literacy in Medicine (REALM) of 0.81. Each selection is scored a \"1\" for correct or a \"0\" for incorrect and scores are summed over items to create a total score. The 36-point scale of the S-TOFHLA is divided into three categories of functional literacy: inadequate (0-16), adequate (17-22) and functional (23-36)." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Research or Clinical Assessment Tool\". Still must add these annotation properties: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available""" ; obo:SCDO_0000340 "Parker RM, Baker DW, Williams MV, Nurss JR. The test of functional health literacy in adults: a new instrument for measuring patients' literacy skills. Journal of General Internal Medicine. 1995;10(10):537-41." ; obo:SCDO_0000484 "Spanish" ; obo:SCDO_1000288 "None" ; dc:source "Parker RM, Baker DW, Williams MV, Nurss JR. The test of functional health literacy in adults: a new instrument for measuring patients' literacy skills. Journal of General Internal Medicine. 1995;10(10):537-41." ; oboInOwl:hasExactSynonym "TOFHLA", "Test of Functional Health Literacy in Adults" ; a owl:Class ; rdfs:label "Test of Functional Health Literacy in Adults (TOFHLA)" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0001146 obo:IAO_0000115 "The Duke Religion Index (DUREL) is a five item scale which measures religiosity in three areas: organizational religiosity (OR), non-organizational religiosity (NOR), and intrinsic religiosity. Two of the questions were derived from large epidemiologic studies and have been shown to have a strong predictive value for many health outcomes. OR has been related to less depression, more social support, better physical health, lower resource utilization, and lower mortality. NOR has been shown to be related to poorer physical health, and greater social support. The other three items were taken from the Hoge 10- item religiosity scale (Hodge et al 1972). The DUREL has high test-retest reliability (intra-class correlation = 0.91), high internal consistency (Cronbach's alpha's = 0.78--0.91)." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Research or Clinical Assessment Tool\". Also requires these properties: -- has cross-cultural adaptation -- has translations""" ; obo:SCDO_0000340 "Koenig, HG and Büssing A. (2010). The Duke University Religion Index (DUREL): A Five-Item Measure for Use in Epidemological Studies. Religions, 1, 78-85." ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Adults with SCD" ; obo:SCDO_0001033 "Used in at least one SCD study" ; obo:SCDO_0001222 "Adults" ; obo:SCDO_0001335 "no" ; obo:SCDO_1000288 "None" ; dc:source "Koenig, HG and Büssing A. (2010). The Duke University Religion Index (DUREL): A Five-Item Measure for Use in Epidemological Studies. Religions, 1, 78-85." ; oboInOwl:hasExactSynonym "DUREL", "The Duke Religion Index" ; a owl:Class ; rdfs:label "The Duke Religion Index (DUREL)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0001150 obo:IAO_0000115 "A medical device used to prevent and treat medical conditions, or to alleviate pain or injury." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Therapeutic Device" ; rdfs:subClassOf obo:SCDO_0001152 . obo:SCDO_0001151 obo:IAO_0000115 "The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D007507" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001151" ; oboInOwl:hasDbXref "MESH:D007507" ; oboInOwl:hasExactSynonym "Lavage", "Lavages", "Therapeutic Irrigations" ; a owl:Class ; rdfs:label "Therapeutic Irrigation" ; rdfs:subClassOf obo:SCDO_0001129 . obo:SCDO_0001152 obo:IAO_0000115 "Procedures, agents or devices concerned with the remedial treatment or prevention of diseases." ; obo:SCDO_0000303 "Chemotherapy to be added in this class? If so, would have to be specific types of chemotherapy relevant to the type of therapeutics class.", "Include as subclasses: -- Prosthesis -- Phototherapy (therapy for Jaundice) -- Risk Reduction? Copy relevant disease modifiers below this.", "Suggest update to description in MESH" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D013812" ; oboInOwl:hasExactSynonym "Therapy", "Treatment" ; a owl:Class ; rdfs:label "Therapeutics" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_0001158 obo:IAO_0000115 "A mutation named with the blend of insertion and deletion. It refers to a length difference between two alleles where it is unknowable if the difference was originally caused by a sequence insertion or by a sequence deletion. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a frameshift mutation." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D054643" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001158" ; oboInOwl:hasDbXref "MESH:D054643" ; oboInOwl:hasExactSynonym "Insertion-Deletion Mutation" ; a owl:Class ; rdfs:label "Indel Mutation" ; rdfs:subClassOf obo:IDOMAL_50000026 . obo:SCDO_0001159 obo:IAO_0000115 "Ending the tobacco habits of smoking, chewing, or snuff use." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D020340" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001159" ; oboInOwl:hasDbXref "MESH:D020340" ; oboInOwl:hasExactSynonym "Tobacco Cessation" ; a owl:Class ; rdfs:label "Tobacco Use Cessation" ; rdfs:subClassOf obo:SCDO_0000487, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002138 ] . obo:SCDO_0001164 obo:IAO_0000115 "A person who practices the art of healing using traditional medicine, a system of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (spiritual therapies); phytotherapy (plant therapy) and other treatments which may not be explained by modern medicine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps MESH." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; dc:source ; oboInOwl:hasExactSynonym "Faith Healer", "Folk Healer", "Healer", "Sangoma", "Shaman" ; a owl:Class ; rdfs:label "Traditional Healer" ; rdfs:subClassOf obo:SCDO_0000108 . obo:SCDO_0001165 obo:IAO_0000115 "An interviewer-administered, two-part test that requires the respondent to organize numerical and alphabetical sequences that are randomly distributed on a piece of paper. The protocol includes instructions for correcting mistakes and instructions for scoring based on speed and accuracy." ; obo:SCDO_0000303 "Suggest update to label in PhenX." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: #131101" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:131101" ; oboInOwl:hasExactSynonym "Executive Function - Adult" ; a owl:Class ; rdfs:label "Trail Making Test" ; rdfs:subClassOf obo:SCDO_0001304 . obo:SCDO_0001166 obo:IAO_0000115 "A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017585" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001166" ; oboInOwl:hasDbXref "MESH:D017585" ; oboInOwl:hasExactSynonym "TCD", "Transcranial Doppler", "Ultrasonography, Doppler, Transcranial" ; a owl:Class ; rdfs:label "Transcranial Doppler Ultrasonography" ; rdfs:subClassOf obo:NCIT_C154865, obo:NCIT_C17230, obo:SCDO_0001129, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0001167 obo:IAO_0000115 "The use of specifically placed small electrodes to deliver electrical impulses across the skin to relieve pain. It is used less frequently to produce anesthesia." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D004561" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001167" ; oboInOwl:hasDbXref "MESH:D004561" ; oboInOwl:hasExactSynonym "Analgesic Cutaneous Electrostimulation", "Electroanalgesia", "Electroanalgesias", "Percutaneous Electrical Nerve Stimulation", "Percutaneous Electrical Neuromodulations", "Percutaneous Neuromodulation Therapies", "Percutaneous Neuromodulation Therapy", "TENS", "Transcutaneous Electric Stimulation", "Transcutaneous Electrical Stimulation", "Transcutaneous Nerve Stimulation", "Transdermal Electrostimulation" ; a owl:Class ; rdfs:label "Transcutaneous Electrical Nerve Stimulation" ; rdfs:subClassOf obo:SCDO_0000049, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000851 ] . obo:SCDO_0001168 obo:IAO_0000115 "Temporary loss of vision in one eye due to a lack of blood flow to the retina." ; obo:SCDO_0000303 "Request inclusion into HP below \"Blindness\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source ; oboInOwl:hasExactSynonym "Amaurosis Fugax", "TMB", "Temporary Blindness" ; a owl:Class ; rdfs:label "Transient Monocular Blindness" ; rdfs:subClassOf obo:HP_0000618, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C38060 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000133 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000417 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:NCIT_C16567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000497 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000017 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:SCDO_0001197 obo:IAO_0000115 "'Work consisting of reporting using a method of detecting genetic causes in human traits and genetic factors in behavior using sets of twins. [Curator team: []]'" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018486" ; oboInOwl:hasDbXref "MESH:D018486" ; a owl:Class ; rdfs:label "obsolete Twin Study" ; rdfs:subClassOf obo:SCDO_0000941 ; owl:deprecated true . obo:SCDO_0001198 obo:IAO_0000115 "Works about methods of detecting genetic etiology in human traits. The basic premise of twin studies is that monozygotic twins carry identical genes, while zygotic twins are genetically no more similar than two siblings born after separate pregnancies. (Last, J.M., A Dictionary of Epidemiology, 2d ed)" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018433" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001198" ; oboInOwl:hasDbXref "MESH:D018433" ; a owl:Class ; rdfs:label "Twin Studies as Topic" ; rdfs:subClassOf obo:SCDO_0300004 . obo:SCDO_0001200 obo:IAO_0000115 "This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "GNT1", "UDP Glucuronosyltransferase Family 1 Member A1", "UGT1", "UGT1A1 Gene" ; a owl:Class ; rdfs:label "UGT1A1" ; rdfs:subClassOf obo:SCDO_0000810 . obo:SCDO_0001204 obo:IAO_0000115 "The region surrounding a city. Most inhabitants of urban areas have nonagricultural jobs. Urban areas are very developed, meaning there is a density of human structures such as houses, commercial buildings, roads, bridges, and railways." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Urban", "Urban Area", "Urban Environment", "Urban Setting" ; a owl:Class ; rdfs:label "Urban Location" ; rdfs:subClassOf obo:GAZ_00000448, obo:SCDO_0000496 . obo:SCDO_0001205 obo:IAO_0000115 "A bioassay to measure urine concentration of albumin, which is produced by the liver and is the most abundant protein in the blood." ; obo:SCDO_0000303 "Label different from source's \"Urinary Microalbumin - Assay\"" ; obo:SCDO_0000340 ; obo:SCDO_0000479 , "PhenX protocol: Urinary Microalbumin Assay #141501" ; obo:SCDO_1000288 "Suggest update to label" ; dc:source ; a owl:Class ; rdfs:comment """In the protocol provided, albumin concentration is measured according to a fluorescent immunoassay (FIA). The protocol also lists reference ranges for healthy adults. The criteria for clinically significant proteinuria have been changed from an albumin-creatinine ratio (ACR) of 30 mg/mmol or more to 3 mg/mmol or more. This is because there is evidence that the risk of adverse outcomes is a continuum and starts at an ACR well below 30 mg/mmol. The Sickle Cell Disease Research and Scientific Panel notes that the terms \"microalbuminuria\" and \"macroalbuminuria\" have been used clinically to describe different levels of abnormal albumin excretion rate: 30-299 mg/g urine creatinine, and >300 mg/gr urine creatinine, for microalbuminuria and macroalbuminuria, respectively. Recently, a new terminology has been proposed: \"low level albuminuria\" instead of microalbuminuia, and \"high level albuminuria\" for macroalbuminuria, since the older terminology could be interpreted as measuring different molecular forms of albumin. Because albuminuria may be affected by non-pathological factors (exercise, menstruation contamination, biological variability, etc.), abnormal values should be confirmed within 1-2 months.""" ; rdfs:label "Urinary Albumin Test" ; rdfs:subClassOf obo:NCIT_C17241, obo:SCDO_0000676, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:CMO_0000003 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000570 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0001209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:SCDO_0001206 obo:IAO_0000115 "A bioassay to measure urine concentration of creatinine, a muscle metabolite that is filtered out of blood by the kidneys." ; obo:SCDO_0000340 ; obo:SCDO_0000479 , "PhenX protocol: Urinary Creatinine - Assay #141601" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001206" ; oboInOwl:hasDbXref "phenX:141601" ; oboInOwl:hasExactSynonym "Urinary Creatinine Assay", "Urine Creatinine Analysis" ; a owl:Class ; rdfs:label "Urinary Creatinine Test" ; rdfs:subClassOf obo:NCIT_C17241, obo:SCDO_0000676, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0001213 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:SCDO_0001207 obo:IAO_0000115 "Any measurement of protein present in urine." ; obo:SCDO_0000303 "Suggest update to description in CMO." ; obo:SCDO_0000340 obo:CMO_0000770 ; obo:SCDO_1000288 "Suggest update to description (currently no description provided)." ; oboInOwl:hasDbXref "CMO:0000770" ; a owl:Class ; rdfs:label "Urinary Protein Measurement" ; rdfs:subClassOf obo:CMO_0000256, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:SCDO_0001208 obo:IAO_0000115 "The organs and passageways concerned with the production and excretion of urine, including the kidneys, ureters, urinary bladder, and urethra." ; obo:IAO_0100001 obo:SCDO_0001347 ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/BTO_0003092" ; oboInOwl:hasDbXref "BTO:0003092" ; a owl:Class ; rdfs:label "deprecated Urinary System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001209 obo:IAO_0000115 "The amount of albumin in a specified volume of urine." ; obo:SCDO_0000303 "Suggest that the CMO removes the second part of the definition and puts as comment, as we have done. Also suggest the change to this second part." ; obo:SCDO_0000340 obo:CMO_0000130 ; obo:SCDO_1000288 "Suggest update to description" ; dc:source ; oboInOwl:hasDbXref "CMO:0000130" ; oboInOwl:hasExactSynonym "Urinary Albumin Concentration", "Urinary Albumin Level", "Urine Albumin Level" ; a owl:Class ; rdfs:comment """Urine albumin levels which are above normal but not detectable with routine protein testing are referred to as low level albuminuria (the old term is microalbuminuria). Because albuminuria may be affected by non-pathological factors (exercise, menstruation contamination, biological variability, etc.), abnormal values should be confirmed within 1-2 months.""" ; rdfs:label "Urine Albumin Concentration" ; rdfs:subClassOf obo:SCDO_0001207, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:CMO_0000003 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000567 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000570 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001205 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0012594 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000201 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000836 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:SCDO_0001210 obo:IAO_0000115 "The amount of albumin excreted into the urine within a specified period of time." ; obo:SCDO_0000303 "Suggest that the CMO removes the second part of the definition and puts as comment, as we have done. Also suggest the change to this second part." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000757" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "CMO:0000757" ; oboInOwl:hasExactSynonym "Urinary Albumin Excretion Rate" ; a owl:Class ; rdfs:comment "If the level of albumin in the urine is above normal but not high enough to be detectable with routine protein testing it is referred to as low level albuminuria (the old term is microalbuminuria)." ; rdfs:label "Urine Albumin Excretion Rate" ; rdfs:subClassOf obo:SCDO_0001207 . obo:SCDO_0001212 obo:IAO_0000115 "A comparison of urine microalbumin, that is, a level of albumin in the urine which is above normal but not detectable with routine protein testing, to the amount of creatinine in a specified volume of urine. Often expressed as albumin concentration divided by creatinine concentration times 1000 mg per gram." ; obo:SCDO_0000303 "Suggest update to description as we have done." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CMO_0000384" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "CMO:0000384" ; oboInOwl:hasExactSynonym "ACR", "ALBCREAT", "Albumin To Creatinine Protein Ratio Measurement", "Albumin-Creatinine Ratio", "Albumin/Creatinine Ratio", "Microalbumin/Creatinine Ratio", "UACR", "Urinary Albumin-Creatinine Ratio", "Urine Albumin Level to Urine Creatinine Level Ratio", "Urine Microalbumin-Creatinine Ratio" ; a owl:Class ; rdfs:label "Urine Albumin-Creatinine Ratio" ; rdfs:subClassOf obo:SCDO_0001207 . obo:SCDO_0001213 obo:IAO_0000115 "The concentration of creatinine in a urine specimen." ; obo:SCDO_0000303 "Request inclusion below \"urine creatinine measurement\" in the CMO." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Urinary Creatinine Concentration", "Urine Creatinine Amount", "Urine Creatinine Concentration Measurement Datum", "Urine Creatinine Level" ; a owl:Class ; rdfs:label "Urine Creatinine Concentration" ; rdfs:subClassOf obo:CMO_0000256, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001206 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0011470 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0011471 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000837 ] . obo:SCDO_0001215 obo:IAO_0000115 "A method in which sulfosalicylic acid (that is, the SSA reagent) is added to a small and equal volume of clear urine. The acidification causes precipitation of protein in the sample (seen as increasing turbidity), which can be subjectively quantitated visually or more precisely quantitated using photometry." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MMO_0000504" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001215" ; oboInOwl:hasDbXref "MMO:0000504" ; oboInOwl:hasExactSynonym "SSA Protein Precipitation Test", "Urine SSA Turbidimetry", "Urine Sulfosalicylic Acid Turbidimetry", "Urine Turbidimetry with Sulfosalicylic Acid" ; a owl:Class ; rdfs:label "Urine Protein Sulfosalicylic Acid Precipitation Test" ; rdfs:subClassOf obo:SCDO_0000120 . obo:SCDO_0001218 obo:IAO_0000115 "The medical specialty concerned with the study, diagnosis, and treatment of diseases of the genitourinary tract." ; obo:SCDO_0000340 "http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17243" ; oboInOwl:hasDbXref "NCIT:C17243" ; a owl:Class ; rdfs:label "obsolete Urology" ; rdfs:subClassOf obo:SCDO_0001208 ; owl:deprecated true . obo:SCDO_0001222 obo:IAO_0000115 "A relation between a measure and the age ranges for which the measure has been validated." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. Should be restricted to all measure/questionnaire classes.""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:label "validated for age ranges" . obo:SCDO_0001223 obo:IAO_0000115 "Works consisting of research using processes by which the reliability and relevance of a procedure for a specific purpose are established." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D023361" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001223" ; oboInOwl:hasDbXref "MESH:D023361" ; a owl:Class ; rdfs:label "Validation Studies" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_0001224 obo:IAO_0000115 "Smoking vapors produced from electronic nicotene delivery systems." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000072137" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001224" ; oboInOwl:hasDbXref "MESH:D000072137" ; oboInOwl:hasExactSynonym "Electronic Cigarrete Use" ; a owl:Class ; rdfs:label "Vaping" ; rdfs:subClassOf obo:SCDO_0001079 . obo:SCDO_0001228 obo:IAO_0000115 "A measure of vascular endothelial cell response to stimulation, for example, by vasoactive substances released by or those that interact with the vascular endothelium." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://circ.ahajournals.org/content/108/17/2054" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Assessment of Endothelial Cell Function", "Endothelium Dysfunction Test", "Vascular Endothelial Function Test" ; a owl:Class ; rdfs:label "Endothelial Function Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:SCDO_0001229 obo:IAO_0000115 "Pain resulting from tissue ischemia as a result of blockage of blood vessels, occurring in a variety of vascular beds, but most commonly in the bone or bone marrow and requiring analgesic medication." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Acute Pain Crisis", "Sickle Crisis", "VOC", "Vaso-Occlusive Crisis", "Vaso-Occlusive Episodes" ; a owl:Class ; rdfs:label "Vaso-Occlusive Crisis" ; rdfs:subClassOf obo:SCDO_0001023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0008623 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0001230 obo:IAO_0000115 "Extraction of blood from a vein using a needle. In human, the basilic, cephalic and median cubital veins are most commonly used as well as the femoral vein." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/MMO_0000090" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001230" ; oboInOwl:hasDbXref "MMO:0000090" ; a owl:Class ; rdfs:label "Venipuncture" ; rdfs:subClassOf obo:SCDO_0000082 . obo:SCDO_0001232 obo:IAO_0000115 "A parent or caregiver questionnaire administered as part of a structured interview that measures day-to-day performance on communication, daily living, socialization, and motor skills. Standard scores can be derived for communication, daily living, socialization, and motor skills subtests or combined to create an Adaptive Behavior Composite (ABC)." ; obo:SCDO_0000303 "Suggest update to label in PhenX as we have done." ; obo:SCDO_0000340 "http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820601" ; obo:SCDO_0000479 "PhenX protocol: Adaptive Behavior/Adaptive Function #820601" ; obo:SCDO_0000481 "Proxy" ; obo:SCDO_0000486 "This measure can be used to identify individuals with developmental disabilities or delays, perform diagnostic evaluations, monitor progress, and develop programs." ; obo:SCDO_0001222 "All ages from birth through age 90" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:820601" ; oboInOwl:hasExactSynonym "VABS", "Vineland Adaptive Behavior Scales", "Vineland-II" ; a owl:Class ; rdfs:label "Vineland Adaptive Behavior Scales, Second Edition (Vineland-II)" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0001234 obo:IAO_0000115 "Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells." ; obo:SCDO_0000303 """Add sub-classes: Hepatitis C Virus (term in NCIT) Hepatitis B Virus (term not found in other ontologies)""" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D014780" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001234" ; oboInOwl:hasDbXref "MESH:D014780" ; oboInOwl:hasExactSynonym "Viruses" ; a owl:Class ; rdfs:label "Virus" ; rdfs:subClassOf obo:OBI_0000925 . obo:SCDO_0001237 obo:IAO_0000115 "Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D014821" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001237" ; oboInOwl:hasDbXref "MESH:D014821" ; oboInOwl:hasExactSynonym "Vitrectomies" ; a owl:Class ; rdfs:label "Vitrectomy" ; rdfs:subClassOf obo:SCDO_0000833, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0007902 ] . obo:SCDO_0001240 obo:IAO_0000115 "Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes." ; obo:SCDO_0000303 "Can this term also be below \"Immunological Assay\"?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001240" ; oboInOwl:hasDbXref "MESH:D015153" ; oboInOwl:hasExactSynonym "Western Immunoblot" ; a owl:Class ; rdfs:label "Western Blot" ; rdfs:subClassOf obo:SCDO_0000424 . obo:SCDO_0001241 obo:IAO_0000115 "An acute onset of wheezing in a person with SCD and co-morbid asthma." ; obo:SCDO_0000340 "Glassberg, Jeffrey A., Robert Strunk, and Michael R. DeBaun. “Wheezing in Children with Sickle Cell Disease.” Current opinion in pediatrics 26.1 (2014): 9–18. PMC. Web. 2 Aug. 2017.", "Paediatr Respir Rev. 2014 Mar;15(1):13-6. doi: 10.1016/j.prrv.2013.10.005. Epub 2013 Oct 31." ; obo:SCDO_0000661 "Synergistic inflammatory response due to both SCD and asthma." ; obo:SCDO_0000662 "Increased severity of episodes." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source "Glassberg, Jeffrey A., Robert Strunk, and Michael R. DeBaun. “Wheezing in Children with Sickle Cell Disease.” Current opinion in pediatrics 26.1 (2014): 9–18. PMC. Web. 2 Aug. 2017.", "Paediatr Respir Rev. 2014 Mar;15(1):13-6. doi: 10.1016/j.prrv.2013.10.005. Epub 2013 Oct 31." ; oboInOwl:hasExactSynonym "Asthma Attack" ; a owl:Class ; rdfs:label "Wheezing Episode with Co-Morbid Asthma" ; rdfs:subClassOf obo:SCDO_0000895, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C18772 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000166 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000898 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000942 ] . obo:SCDO_0001246 obo:IAO_0000115 "An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3rd Ed)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018599" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001246" ; oboInOwl:hasDbXref "MESH:D018599" ; oboInOwl:hasExactSynonym "Sorceries", "Sorcery" ; a owl:Class ; rdfs:label "Witchcraft" ; rdfs:subClassOf obo:SCDO_0000107 . obo:SCDO_0001247 obo:IAO_0000115 "The WHOQOL is a quality of life assessment developed by the WHOQOL Group with fifteen international field centres, simultaneously, in an attempt to develop a quality of life assessment that would be applicable cross-culturally." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Research or Clinical Assessment Tool\". Still must add these annotation properties: -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations""" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Healthy people; Clinic patients" ; obo:SCDO_0001033 "Demonstrated validity with SCD populations; at least two publications using the measure" ; obo:SCDO_1000288 "None" ; dc:source "WHOQOL Group (1993). Measuring quality of life: The development of the World Health Organisation quality of life instrument (WHOQOL). Geneva: WHO." ; oboInOwl:hasExactSynonym "WHOQOL", "World Health Organisation Quality of Life Instrument" ; a owl:Class ; rdfs:label "World Health Organisation Quality of Life Instrument (WHOQOL)" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0001249 obo:IAO_0000115 "The visual output that an X-ray machine produces." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "X-Ray Image" ; rdfs:subClassOf obo:SCDO_1000313, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000963 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:OBI_0001138 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001250 obo:IAO_0000115 "The visual output that an X-ray machine produces when imaging the chest." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Chest X-Ray Image" ; a owl:Class ; rdfs:label "X-Ray Image of Chest" ; rdfs:subClassOf obo:SCDO_0001249, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000217 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000193 ; owl:someValuesFrom obo:OBI_0001138 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0001252 obo:IAO_0000115 "Medical treatment involving the use of controlled amounts of X-Rays." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D014964" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001252" ; dc:source ; oboInOwl:hasDbXref "MESH:D014964" ; oboInOwl:hasExactSynonym "Roentgenotherapy", "X Ray Therapy", "X-ray Beam Therapy", "Xray Therapy" ; a owl:Class ; rdfs:label "X-Ray Therapy" ; rdfs:subClassOf obo:SCDO_0001129, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:OBI_1110053 ] . obo:SCDO_0001253 obo:IAO_0000115 "Penetrating, high-energy electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the gamma rays wavelength range. The distinction between gamma rays and X-rays is based on their radiation source." ; obo:SCDO_0000303 "This should probably be removed." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D014965" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001253" ; oboInOwl:hasDbXref "MESH:D014965" ; oboInOwl:hasExactSynonym "X-Radiation", "X-Ray Electromagnetic Radiation" ; a owl:Class ; rdfs:label "X-Rays" ; rdfs:subClassOf obo:OBI_0001138, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001267 obo:IAO_0000115 "The EQ-5D is a widely-used generic instrument for describing health-related quality of life states in five dimensions scored from 1 to 3 or 1 to 5, and a visual analogue scale to record self-rated health state from 0 to100. These provide a simple descriptive profile and a single index value for health status. The EQ-5D can also be used to calculate health utilities and determine the quality-adjusted life years associated with a health state. There is also a youth version (EQ-5D-Y)." ; obo:SCDO_0000340 "The EuroQol Group. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy. 1990; 16(3):199-208." ; obo:SCDO_0000470 "Multiple countries and cultural groups" ; obo:SCDO_0000481 "Self" ; obo:SCDO_0000482 "Healthy People; Clinic Patients" ; obo:SCDO_0001033 "Widely used around the world, also used in SCD" ; obo:SCDO_0001222 "Adults and Youth (8 to 18 years)" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source "Anie KA, Grocott H, White L, Dzingina M, Rogers G, Cho G (2012). Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease. BMJ Open, 2, e001274. doi:10.1136/bmjopen-2012-001274.", "Howard, J, Malfroy, M, Llewelyn, C et al. The Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trial. Lancet. 2013; 381(9870):930–938.", "The EuroQol Group. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy. 1990; 16(3):199-208." ; oboInOwl:hasExactSynonym "EQ-5D", "EuroQol Five Dimension Self-Report Questionnaire", "EuroQol Five Dimensions Questionnaire", "EuroQol Five-Dimensional Questionnaire", "European Quality of Life Five Dimension Five Level Scale Questionnaire" ; a owl:Class ; rdfs:label "EuroQol Five Dimensions Questionnaire (EQ-5D)" ; rdfs:subClassOf obo:SCDO_0000951 . obo:SCDO_0001268 obo:IAO_0000115 "The FACIT-Sp is a 12-item measure that asks participants to indicate how true various statements are about them on a Likert scale of 0 (\"not at all\") to 4 (\"very much\"). Responses on the FACIT-Sp are summed to create a total score, ranging from 0 to 48, with higher scores representing higher levels of spirituality." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." ; obo:SCDO_0000340 "Peterman AH, Fitchett G, Brady MJ, et al. Measuring spiritual well-being in people with cancer: the functional assessment of chronic illness therapy—Spiritual Well-being Scale (FACIT- Sp). Ann Behav Med. 2002;24:49–58." ; obo:SCDO_0000481 "Self; Proxy (Parent report)" ; obo:SCDO_0000482 "Children with SCD and their parents" ; obo:SCDO_0001033 "Demonstrated validity in SCD studies." ; obo:SCDO_0001222 "Children and adults" ; obo:SCDO_1000288 "None" ; dc:source "Peterman AH, Fitchett G, Brady MJ, et al. Measuring spiritual well-being in people with cancer: the functional assessment of chronic illness therapy—Spiritual Well-being Scale (FACIT- Sp). Ann Behav Med. 2002;24:49–58." ; oboInOwl:hasExactSynonym "FACIT-Sp Scale", "Functional Assessment of Chronic Illness Therapy-Spirituality Scale" ; a owl:Class ; rdfs:label "Functional Assessment of Chronic Illness Therapy-Spirituality (FACIT-Sp) Scale" ; rdfs:subClassOf obo:SCDO_0000953 . obo:SCDO_0001284 obo:IAO_0000115 "The application of modern theories of learning and conditioning in the treatment of behavior disorders." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D001521" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001284" ; oboInOwl:hasDbXref "MESH:D001521" ; oboInOwl:hasExactSynonym "Behavior Modification", "Behavior Modifications", "Behavior Therapies", "Behavior Therapy", "Conditioning Therapies", "Conditioning Therapy" ; a owl:Class ; rdfs:label "Behaviour Therapy" ; rdfs:subClassOf obo:SCDO_0000940, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000106 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001513 ] . obo:SCDO_0001288 obo:IAO_0000115 "A primary headache disorder that is characterized by severe, strictly unilateral pain which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial sweating, eyelid edema, and miosis." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003027" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001288" ; oboInOwl:hasDbXref "MESH:D003027" ; oboInOwl:hasExactSynonym "Acute Severe Headache", "Cluster Headaches", "Migraine, Neuralgic" ; a owl:Class ; rdfs:label "Cluster Headache" ; rdfs:subClassOf obo:HP_0012638, obo:SCDO_0000851, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:OGMS_0000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001292 obo:IAO_0000115 "Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001292" ; dc:source "http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.00" ; oboInOwl:hasDbXref "ICD10CM:D57.00" ; oboInOwl:hasExactSynonym "D57.00", "Hb-SS disease with (painful) crisis NOS", "Hb-SS disease with crisis, unspecified", "Hb-SS disease with vasoocclusive pain NOS", "Hemoglobin S sickling disorder with crisis", "Sickle cell anemia, crisis" ; a owl:Class ; rdfs:label "D57.00 Hb-SS disease with crisis, unspecified" ; rdfs:subClassOf obo:SCDO_0000312, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_0001295 obo:IAO_0000115 "An instrument used in the detection and diagnosis of heart abnormalities that measures electrical potentials on the body surface and generates a record of the electrical currents associated with heart muscle activity." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://en.wiktionary.org/wiki/electrocardiograph" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Cardiograph", "Electrocardiographic Instrument" ; a owl:Class ; rdfs:label "Electrocardiograph" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0000417 ] . obo:SCDO_0001296 obo:IAO_0000115 "The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017707" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001296" ; oboInOwl:hasDbXref "MESH:D017707" ; oboInOwl:hasExactSynonym "Erythrocyte Transfusions", "Red Blood Cell Transfusion", "Red Blood Cell Transfusions", "Transfusion, Erythrocyte", "Transfusions, Erythrocyte" ; a owl:Class ; rdfs:label "Erythrocyte Transfusion" ; rdfs:subClassOf obo:SCDO_0000138, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001297 obo:IAO_0000115 "A measure that is critical to the collection of the measure at hand or is necessary for the interpretation of results for the measure at hand. Without such information, the data collected would be incomplete or misleading." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:comment "Essential measures have been attributed according to information in PhenX." ; rdfs:label "has essential measure" . obo:SCDO_0001299 obo:IAO_0000115 "Works consisting of studies determining the effectiveness or utility of processes, personnel, and equipment." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D023362" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001299" ; oboInOwl:hasDbXref "MESH:D023362" ; a owl:Class ; rdfs:label "Evaluation Studies" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_0001303 obo:IAO_0000115 "Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001303" ; oboInOwl:hasDbXref "MESH:D005078" ; oboInOwl:hasExactSynonym "Exchange Blood Transfusion" ; a owl:Class ; rdfs:label "Exchange Transfusion, Whole Blood" ; rdfs:subClassOf obo:SCDO_0000147, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001789 ] . obo:SCDO_0001304 obo:IAO_0000115 "An interviewer-administered test to measure a respondent's system of high-level cognitive functions such as abstract thinking, rule acquisition, cognitive flexibility, and goal-oriented behavior." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001304" ; oboInOwl:hasDbXref "phenX:131100" ; a owl:Class ; rdfs:label "Executive Function Measure" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033 . obo:SCDO_0001312 obo:IAO_0000115 "The organ of vision that consists of the eyeball and the optic nerve." ; obo:IAO_0100001 obo:SCDO_1000294 ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/eye" ; oboInOwl:hasExactSynonym "Oculus" ; a owl:Class ; rdfs:label "deprecated Eye" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001316 obo:IAO_0000115 "Facial paralysis is loss of facial movement because of nerve damage." ; obo:IAO_0100001 obo:SCDO_0001315 ; obo:SCDO_0000303 "Is this not the same thing as \"Facial Nerve Palsy\"?" ; oboInOwl:hasDbXref "DOID:13934" ; a owl:Class ; rdfs:label "obsolete Facial Paralysis" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0001319 obo:IAO_0000115 "Inability to function due to tiredness related to sickle cell disease." ; obo:SCDO_0000303 "Use the literature cited here to link to other phenotypes." ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; oboInOwl:hasExactSynonym "Fatigability", "Fatigable", "Lassitude", "Tiredness" ; a owl:Class ; rdfs:label "Fatigue" ; rdfs:seeAlso ; rdfs:subClassOf obo:HP_0025142, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001320 obo:IAO_0000115 "Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D005240" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001320" ; oboInOwl:hasDbXref "MESH:D005240" ; a owl:Class ; rdfs:label "Feasibility Studies" ; rdfs:subClassOf obo:SCDO_0300004 . obo:SCDO_0001321 obo:IAO_0000115 "A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance." ; obo:SCDO_0000303 "Were these specific synonyms selected form the long list in the description source because of specific relevance to SCD?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001321" ; oboInOwl:hasDbXref "MESH:D005283" ; oboInOwl:hasExactSynonym "Duragesic", "Durogesic", "N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide", "Phentanyl" ; a owl:Class ; rdfs:label "Fentanyl" ; rdfs:subClassOf obo:CHEBI_35482, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0001322 obo:IAO_0000115 "A bioassay to measure the serum concentration of ferritin (i.e., iron)." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Serum or Plasma Ferritin\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:811301" ; oboInOwl:hasExactSynonym "Ferritin Blood Test", "Ferritin Measurement", "Plasma Ferritin Assay", "Plasma Ferritin Test", "Serum Ferritin Assay" ; a owl:Class ; rdfs:label "Serum Ferritin Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0001323 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:SCDO_0001323 obo:IAO_0000115 "The amount of ferritin found in a specified volume of serum." ; obo:SCDO_0000303 "Suggest update to description and label of \"ferritin measurement\" in the EFO." ; obo:SCDO_1000288 "Suggest update to description" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Blood Serum Ferritin Concentration", "Blood Serum Ferritin Concentration Measurement Datum" ; a owl:Class ; rdfs:label "Serum Ferritin Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C16564 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0001322 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001325 obo:IAO_0000115 "An instrument which is used to count and sort microscopic particles suspended in a buffer. This instrument consists of a flow cell, at least one lamp or laser, a variable number of emission detectors or photomultipliers, a system that converts analog signals to digital, and a computer to run the system and collect and analyze the data output." ; obo:SCDO_0000303 "Not sure whether this can be classified as a \"Medical Device\"." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/npo#NPO_1769" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001325" ; oboInOwl:hasDbXref "NPO:1769" ; a owl:Class ; rdfs:label "Flow Cytometer" ; rdfs:subClassOf obo:SCDO_0000376, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000191 ; owl:someValuesFrom obo:SCDO_0001326 ] . obo:SCDO_0001326 obo:IAO_0000115 "Flow cytometry uses the principles of light scattering and fluorescence from fluorochrome molecules to generate specific multi-parameter data from particles and cells in the size range of 0.5um to 40um diameter." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001326" ; oboInOwl:hasDbXref "BAO:0000005" ; a owl:Class ; rdfs:label "Flow Cytometry" ; rdfs:subClassOf obo:SCDO_0000896, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000192 ; owl:someValuesFrom obo:SCDO_0001325 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000975 ] . obo:SCDO_0001327 obo:IAO_0000115 "Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D005451" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001327" ; oboInOwl:hasDbXref "MESH:D005451" ; oboInOwl:hasExactSynonym "Fluorescence Angiography" ; a owl:Class ; rdfs:label "Fluorescein Angiography" ; rdfs:subClassOf obo:OBI_0000185, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001328 obo:IAO_0000115 "A rare neurologic movement disorder characterized by sustained muscle contractions of a single body region, usually producing twisting and repetitive movements or abnormal postures or positions." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001328" ; oboInOwl:hasDbXref "ORPHA:1866" ; a owl:Class ; rdfs:label "Focal Dystonia" ; rdfs:subClassOf obo:HP_0012638 . obo:SCDO_0001329 obo:IAO_0000115 "A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001329" ; oboInOwl:hasDbXref "MESH:D005492" ; oboInOwl:hasExactSynonym "Folacin", "Folate", "Folvite", "L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-", "Pteroylglutamic Acid", "Vitamin B9", "Vitamin M" ; a owl:Class ; rdfs:label "Folic Acid" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0000922, obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000519 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000530 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001330 obo:IAO_0000115 "Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D005500" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001330" ; oboInOwl:hasDbXref "MESH:D005500" ; oboInOwl:hasExactSynonym "Follow Up Studies", "Follow-Up Study", "Followup Studies" ; a owl:Class ; rdfs:label "Follow-Up Studies" ; rdfs:subClassOf obo:SCDO_0000263 . obo:SCDO_0001334 obo:IAO_0000115 "An observable characteristic of disease that is persistent and long standing." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C14141", "http://semanticscience.org/resource/SIO_010056" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasDbXref "NCIT:C14141", "SIO:010056" ; a owl:Class ; rdfs:label "Chronic Phenotype" ; rdfs:subClassOf obo:HP_0000118 . obo:SCDO_0001335 obo:IAO_0000115 "A relation between a measure (e.g. a survey) and an indication of whether the measure is freely available." ; obo:SCDO_0000303 """Requested inclusion of this property into RO. Check details here again after inclusion. Should be restricted to all measure/questionnaire classes.""" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; dc:creator "SCDO" ; a owl:AnnotationProperty ; rdfs:comment "'yes' indicates that the measure is freely available. 'no' indicates that the measure is not freely available." ; rdfs:label "freely available" . obo:SCDO_0001336 obo:IAO_0000115 "Terms deprecated in the \"Phenotype\" class." ; a owl:Class ; rdfs:label "from phenotype" ; rdfs:subClassOf obo:SCDO_0000359 . obo:SCDO_0001339 obo:IAO_0000115 "A questionnaire to measure the health status of individuals who had a stroke." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001339" ; oboInOwl:hasDbXref "phenX:820700" ; oboInOwl:hasExactSynonym "Functionality After Stroke Diagnostic Instrument" ; a owl:Class ; rdfs:label "Functionality After Stroke Measure" ; rdfs:subClassOf obo:SCDO_0000953, obo:SCDO_1000297, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_0001340 obo:IAO_0000115 "'The system concerned with the function and disorders of the gastrointestinal tract, including stomach, intestines, and associated organs including liver, pancreas and gall bladder. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0000335 ; obo:SCDO_0000340 "http://medical-dictionary.thefreedictionary.com/gastroenterology" ; oboInOwl:hasExactSynonym "gastrointestinal tract" ; a owl:Class ; rdfs:label "deprecated Gastrointestinal System" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001342 obo:IAO_0000115 "Combined effects of genotypes and environmental factors together to affect phenotypic characteristics." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D059647" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001342" ; oboInOwl:hasDbXref "MESH:D059647" ; a owl:Class ; rdfs:label "Gene-Environment Interaction" ; rdfs:subClassOf obo:SCDO_0000391 . obo:SCDO_0001364 obo:IAO_0000115 "A relation between a particular genotype or disorder and the pattern in which the particular genotype or disorder is passed from one generation to the next." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has mode of inheritance" . obo:SCDO_0001369 obo:IAO_0000115 "Deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents." ; obo:SCDO_0000303 "Suggest update to description in NCIT" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C17248" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C17248" ; a owl:Class ; rdfs:label "Genetic Variation" ; rdfs:subClassOf obo:SCDO_0000765, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:OGMS_0000023 ] . obo:SCDO_0001373 obo:IAO_0000115 "'To be defined by an expert [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000041 ; obo:SCDO_0000303 "made a synonym of HBB, GLU6LYS" ; a owl:Class ; rdfs:label "deprecated beta C mutation" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0001374 a owl:Class ; rdfs:label "obsolete heterozygous beta c mutation" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0001375 a owl:Class ; rdfs:label "obsolete homozygous beta c mutation" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0001376 obo:IAO_0000115 "'To be defined by an expert [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000042 ; obo:SCDO_0000303 "Made a synonym of \"HBB, GLU26LYS\"" ; a owl:Class ; rdfs:label "deprecated beta E mutation" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0001377 obo:IAO_0000115 "'To be defined by an expert [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000039 ; obo:SCDO_0000303 "Made a synonym of HBB, GLU6VAL" ; a owl:Class ; rdfs:label "deprecated beta S mutation" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0001378 obo:IAO_0000115 "This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA2." ; obo:SCDO_0000303 "Suggest update to description in NCIT." ; obo:SCDO_0000340 , "http://www.ontobee.org/ontology/NCIT?iri=http://purl.obolibrary.org/obo/NCIT_C75429" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C75429" ; oboInOwl:hasExactSynonym "HBA1 Gene", "Hemoglobin Subunit Alpha 1 Gene", "Hemoglobin, Alpha 1 Gene" ; a owl:Class ; rdfs:label "HBA1" ; rdfs:subClassOf obo:SCDO_1000361 . obo:SCDO_0001379 obo:IAO_0000115 "This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA1." ; obo:SCDO_0000303 "Suggest update to description in NCIT." ; obo:SCDO_0000340 , "http://purl.obolibrary.org/obo/NCIT_C75432" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasExactSynonym "HBA2 Gene", "Hemoglobin Subunit Alpha 2 Gene", "Hemoglobin, Alpha 2 Gene" ; a owl:Class ; rdfs:label "HBA2" ; rdfs:subClassOf obo:SCDO_1000361 . obo:SCDO_0001382 obo:IAO_0000115 "Gamma Globin is a type of polypeptide chain that when in combination with alpha globin chains forms fetal hemoglobin. Beta-Hemoglobin subunits gamma-1 (147 aa, ~16 kDa) and gamma-2 (147 aa, ~16 kDa) are encoded by the human HBG1 and HBG2 gene respectively, in the beta-globin gene cluster. These proteins play a role in the transport of oxygen to tissues of the fetal body." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "https://www.genecards.org/cgi-bin/carddisp.pl?gene=HBG1" ; obo:SCDO_1000288 "None" ; dc:source ; oboInOwl:hasExactSynonym "Gamma-Globin", "Haemoglobin Gamma Chain", "Haemoglobin Subunit Gamma", "Hemoglobin Gamma Chain" ; a owl:Class ; rdfs:label "Hemoglobin Subunit Gamma" ; rdfs:subClassOf obo:SCDO_1000012 . obo:SCDO_0001384 obo:IAO_0000115 "A reduction in the ratio of production of alpha globin to that of gamma globin." ; obo:SCDO_0000303 "Request inclusion into the HPO below \"Imbalanced Hemoglobin Synthesis\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Nicole Vasilevsky)" ; oboInOwl:hasExactSynonym "Increased Gamma/Alpha Synthesis Ratio" ; a owl:Class ; rdfs:label "Reduced Alpha/Gamma Synthesis Ratio" ; rdfs:subClassOf obo:HP_0005560, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001386 ] . obo:SCDO_0001385 obo:IAO_0000115 "The state, in utero or shortly after birth, in which all four alpha globin genes are deleted or inactivated resulting in absent alpha globin synthesis. If gamma globin synthesis persists, then the resulting phenotype is hemoglobin Barts (four gamma chains) and hemoglobin Bart hydrops fetalis." ; obo:SCDO_0000303 "Request inclusion into HPO below \"Reduced Alpha/Gamma Synthesis Ratio\" (also requested for inclusion)." ; obo:SCDO_0000340 "Marengo-Rowe, A.J., 2007, January. The thalassemias and related disorders. In Baylor university medical center proceedings (Vol. 20, No. 1, pp. 27-31). Taylor & Francis." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "Absence of Alpha Globin Synthesis with Gamma Globin Synthesis" ; rdfs:subClassOf obo:SCDO_0001384, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001387 ] . obo:SCDO_0001386 obo:IAO_0000115 "A deletion in or of the HBA1 or HBA2 gene that can result in some form of alpha thalassemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology", """Still need to add one sub-class: the complete deletion of the HBA1 and HBA2 genes on one chromosome 16, combined with a defect (deletional or nondeletional) in either the HBA1 or HBA2 gene on the other chromosome 16, leaving one functioning gene present (https://www.snpedia.com/index.php/Alpha_Thalassemia)""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Alpha-Globin Cluster Deletion", "Alpha-Globin Gene Cluster Deletion", "HBA Locus Deletion" ; a owl:Class ; rdfs:label "Alpha-Globin Locus Deletion" ; rdfs:subClassOf obo:NCIT_C19296, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000251 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ] . obo:SCDO_0001387 obo:IAO_0000115 "Deletion of all four alpha-globin genes resulting in the most severe form of alpha thalassemia, Hemoglobin Barts Hydrops Fetalis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "Homozygous Deletion of HBA1 and HBA2" ; rdfs:subClassOf obo:SCDO_0001386, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000518 ] . obo:SCDO_0001388 obo:IAO_0000115 "Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt genetic translation of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016254" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001388" ; oboInOwl:hasDbXref "MESH:D016254" ; oboInOwl:hasExactSynonym "Gene Insertion", "Insertion Mutation" ; a owl:Class ; rdfs:label "Insertion" ; rdfs:subClassOf obo:IDOMAL_50000026 . obo:SCDO_0001436 obo:IAO_0000115 "The administration of oxygen to an individual. It is of paramount importance in the peri-operative care of SCD patients as hypoxaemia predisposes to sickling." ; obo:SCDO_0000340 obo:NCIT_C94624, obo:SCDO_1000145 ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasExactSynonym "Supplemental Oxygen Therapy" ; a owl:Class ; rdfs:label "Oxygen Therapy" ; rdfs:subClassOf obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:SCDO_0001511 obo:IAO_0000115 "Renal medullary carcinoma is a rare, aggressive subtype of renal cell carcinoma characterized by a large, white or tan, firm, infiltrative tumor with microabscess-like foci centered in the renal medulla, typically presenting with hematuria, abdominal/flank pain, weight loss and fever. It is associated with sickle cell trait and disease and metastasis to the bones and lungs is common at time of diagnosis." ; obo:SCDO_0000340 "http://www.orpha.net/ORDO/Orphanet_319319" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001511" ; dc:source "Shetty A, Matrana MR. Renal medullary carcinoma: a case report and brief review of the literature. Ochsner J. 2014;14(2):270-5." ; oboInOwl:hasDbXref "ORPHA:319319" ; oboInOwl:hasExactSynonym "Kidney Medullary Carcinoma", "RMC", "Renal Medullary Cancer" ; a owl:Class ; rdfs:label "Renal Medullary Carcinoma" ; rdfs:subClassOf obo:HP_0000077, obo:SCDO_0001054, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001551 obo:IAO_0000115 "A part of anthropological linguistics concerned with the interrelation between a language and the cultural behavior of those who speak it." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001551" ; dc:source ; oboInOwl:hasDbXref "APAONTO:Ethnolinguistics" ; a owl:Class ; rdfs:label "Ethnolinguistics" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_0001604 obo:IAO_0000115 "That period when the patient with sickle cell anaemia is free of infection, pain, or other disease processes." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "Juwah, A. I., Nlemadim, E. U., & Kaine, W. (2004). Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria. Archives of disease in childhood, 89(6), 572-576." ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; oboInOwl:hasExactSynonym "SCD Steady State" ; a owl:Class ; rdfs:label "Steady State" ; rdfs:subClassOf obo:SCDO_0000895, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0001611 obo:IAO_0000115 "A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism." ; obo:IAO_0100001 obo:SCDO_0000674 ; a owl:Class ; rdfs:label "deprecated-Renal Insufficiency" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001624 obo:IAO_0000115 "Not anemic, i.e. no reduction in erythrocytes volume and/or hemoglobin concentration." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Nonanemic" ; a owl:Class ; rdfs:label "Non-Anemic" ; rdfs:subClassOf obo:NCIT_C3833 . obo:SCDO_0001626 obo:IAO_0000115 "An amino acid-specifying codon that has been converted to a stop codon by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018389" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001626" ; oboInOwl:hasDbXref "MESH:D018389" ; a owl:Class ; rdfs:label "Nonsense Codon" ; rdfs:subClassOf obo:SCDO_0004623 . obo:SCDO_0001715 obo:IAO_0000115 "Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat." ; obo:IAO_0100001 obo:SCDO_0000228 ; obo:SCDO_0000303 "This term already exists in the ontology as 'Chronic Neuropathic Pain' (SCDO:0000228), however when searching other ontologies, the term 'chronic' is included in the definition. I have therefore edited the definition to include the term 'chronic'. Please review as to whether we need to change the label that currently exists in SCDO. Is treated with: amitriptyline, duloxetine, gabapentin, or pregabalin." ; a owl:Class ; rdfs:label "deprecated-Neuropathic Pain" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0001751 obo:IAO_0000115 "Deletion of both HBA2 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Trans Deletion of HBA2" ; a owl:Class ; rdfs:label "Homozygous Deletion of HBA2" ; rdfs:subClassOf obo:SCDO_0001386 . obo:SCDO_0001765 obo:IAO_0000115 "A mutation in the beta-globin gene, HBB, that results in reduced beta globin synthesis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Beta-Minus Thalassemia Mutation" ; rdfs:subClassOf obo:SCDO_0009731, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000159 ] . obo:SCDO_0001851 obo:IAO_0000115 "A rapid heartrate that exceeds the range of the normal resting heartrate for age, gender or patient population." ; obo:SCDO_0000303 """Suggest update to description in HPO. The original description stated 'A rapid heartrate that exceeds the range of the normal resting heartrate for age', however I think it should be recommended that gender and patient population be included.""" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/HP_0001649" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0001649" ; oboInOwl:hasExactSynonym "Fast Heart Rate", "Heart Racing", "Racing Heart" ; a owl:Class ; rdfs:label "Tachycardia" ; rdfs:subClassOf obo:HP_0011025, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0001997 obo:IAO_0000115 "The process whereby a mutation in a hemoglobin molecule causes conformational changes in the hemoglobin molecule, which cause increased hydrophobicity of the molecule, which result in the formation of crystals consisting of the mutated hemoglobin molecules. This type of crystallisation is observed in hemoglobins with the HbC mutation." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Crystallisation of Haemoglobin", "Crystallization of Haemoglobin", "Crystallization of Hemoglobin", "Haemoglobin Crystallisation", "Haemoglobin Crystallization", "Hemoglobin Crystallisation", "Hemoglobin Crystallization" ; a owl:Class ; rdfs:label "Crystallisation of Hemoglobin" ; rdfs:subClassOf obo:SCDO_1000253, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000041 ] . obo:SCDO_0002039 obo:IAO_0000115 "A deficiency of the essential metal Zinc; an essential cofactor for many enzymes. Zinc deficiency is caused by a lack of zinc in the diet, loss of zinc after absorption, for example through loss through burns, inability to absorb Zinc, or increased loss through exercise." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002039" ; oboInOwl:hasDbXref "EFO:1000003" ; a owl:Class ; rdfs:label "Zinc Deficiency" ; rdfs:subClassOf obo:SCDO_1000261 . obo:SCDO_0002106 obo:IAO_0000115 "Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_1001190" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002106" ; oboInOwl:hasDbXref "EFO:1001190" ; a owl:Class ; rdfs:label "Splenic Infarction" ; rdfs:subClassOf obo:HP_0001743, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0002107 obo:IAO_0000115 "This represents the phenotypic feature of mutational effects on a given property of an organism biological system [Gaston K. Mazandu, []]." ; a owl:Class ; rdfs:label "deprecated-Nature of Mutations" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0002125 obo:IAO_0000115 "The privacy of information and its protection against unauthorized disclosure." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003219" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002125" ; oboInOwl:hasDbXref "MESH:D003219" ; oboInOwl:hasExactSynonym "Privileged Communications" ; a owl:Class ; rdfs:label "Confidentiality" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_0002130 obo:IAO_0000115 "The pattern of gene expression at the level of genetic transcription in a specific organism or under specific circumstances in specific cells." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D059467" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002130" ; oboInOwl:hasDbXref "MESH:D059467" ; oboInOwl:hasExactSynonym "Gene Expression Levels", "Gene Expression Profile", "Gene Expression Profiles" ; a owl:Class ; rdfs:label "Transcriptome" ; rdfs:subClassOf obo:SCDO_0005722 . obo:SCDO_0002240 obo:IAO_0000115 "The presence and extensiveness of a disease in the body. It is objectively evaluated through diagnostic testing and physiological examination of the impaired biological organs or tissues, in cases in which disease severity can be distinguished from other realms of health, as in heart disease." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. This exists in the Influenza Ontology, but their definition is not ideal.""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasExactSynonym "Severity" ; a owl:Class ; rdfs:label "Disease Severity" ; rdfs:subClassOf obo:NCIT_C43646 . obo:SCDO_0002243 obo:IAO_0000115 "Reimbursement of research participants for costs directly incurred during the research, such as travel costs and reasonable compensation for their inconvenience and time spent. Compensation can be monetary or non-monetary." ; obo:SCDO_0000303 """Request inclusion into relevant ontology The label for this term has been changed to be more specific than the original \"Compensation\".""" ; obo:SCDO_0000340 "International Ethical Guidelines for Health-related Research Involving Humans, Fourth Edition. Geneva, Council for International Organizations of Medical Sciences (CIOMS); 2016." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Study Participant Compensation" ; a owl:Class ; rdfs:comment "Research participants should be reasonably reimbursed for costs directly incurred during the research, such as travel costs, and compensated reasonably for their inconvenience and time spent. Compensation can be monetary or non-monetary. Compensation must not be so large as to induce potential participants to consent to participate in the research against their better judgment (\"undue inducement\"). A local research ethics committee must approve reimbursement and compensation for research participants." ; rdfs:label "Research Participant Compensation" ; rdfs:subClassOf obo:NCIT_C19332 . obo:SCDO_0002305 obo:IAO_0000115 "A mutation wholly or partly responsible for causing Hemoglobin D Disease." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hemoglobin D Disease Causal Mutation" ; rdfs:subClassOf obo:IDOMAL_50000026 . obo:SCDO_0002337 obo:IAO_0000115 "The abiding by applicable principles such as 1. compliance by research institutions; 2. obtaining and documenting informed consent; 3. Research Ethics Committee membership function, operations, review of research, and record keeping; 4. additional protection for certain vulnerable research subjects - pregnant women, prisoners, and children" ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research. [Bethesda, Md.]", "Research ethics committees: Basic concepts for capacity building. International Ethical Guidelines for Health-related Research Involving Humans, Fourth Edition. Geneva. Council for International Organizations of Medical Sciences (CIOMS); 2016.", "The Commission, 1978. World Health Organization. Geneva: WHO Document Production Services; 2009." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Ethical Conduct" ; rdfs:subClassOf obo:SCDO_1000430 . obo:SCDO_0002475 obo:IAO_0000115 "A mutation in the beta-globin gene, HBB, that results in absent beta globin synthesis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Beta Null Mutation" ; a owl:Class ; rdfs:label "Beta-Zero Thalassemia Mutation" ; rdfs:subClassOf obo:SCDO_0009731, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000067 ] . obo:SCDO_0002674 obo:IAO_0000115 "An abnormality of the body's metabolism or homeostasis." ; obo:SCDO_0000303 "Suggest update to description in HPO. Currenlty the HPO does not have a description." ; obo:SCDO_0000340 obo:HP_0001939 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0001939" ; oboInOwl:hasExactSynonym "Homeostasis Abnormality", "Metabolism Abnormality" ; a owl:Class ; rdfs:label "Abnormality of Metabolism/Homeostasis" ; rdfs:subClassOf obo:HP_0000118, obo:MP_0005376 . obo:SCDO_0002798 obo:IAO_0000115 "Naturally occurring genetic variations associated with drug response. While these variants are not markers for genetic predisposition to disease, they influence pharmacokinetics and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., angiotensin converting enzyme; cytochrome P-450 CYP2D6)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002798" ; oboInOwl:hasDbXref "MESH:D000071184" ; a owl:Class ; rdfs:label "Pharmacogenomic Variants" ; rdfs:subClassOf obo:NCIT_C17004 . obo:SCDO_0002814 obo:IAO_0000115 "'The hemoglobin molecule that transports oxygen in the blood is made up of a number of components. Human hemoglobin is a tetramer: in adults it is made up of two alpha globins and two beta globins; in the fetus, of two alpha and two g globins; and in the embryo, two e and two z globins. The sequences of these five globin types are similar and the genes that code for them occur in clusters on the chromosomes. In humans, there are two main clusters of globin genes: the alpha globin cluster on chromosome 16 and the beta globin cluster on chromosome 11. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0000456 ; obo:SCDO_0000340 "http://www2.nau.edu/~bio372-c/class/evolution/glbgnclst.htm" ; a owl:Class ; rdfs:label "deprecated Globin Gene" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0002829 obo:IAO_0000115 "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a material) to be used for testing, analysis, inspection, investigation, demonstration, or trial use." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0002829" ; oboInOwl:hasDbXref "SIO:001050" ; a owl:Class ; rdfs:label "Sample" ; rdfs:subClassOf obo:NCIT_C19332 . obo:SCDO_0002939 obo:IAO_0000115 "Deoxygenated malfunctioning or mutated hemoglobins which clump together and form a long polymer in a process called polymerisation." ; obo:SCDO_0000303 """Request inclusion in the HPO, below \"Abnormal Hemoglobin\". Description still needs work.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Khuthala Mnika)" ; oboInOwl:hasExactSynonym "Hemoglobin Polymer", "Polymerised Haemoglobin", "Polymerized Hemoglobin", "Sickle Hemoglobin Polymer", "Sickling Hemoglobin" ; a owl:Class ; rdfs:label "Polymerised Hemoglobin" ; rdfs:subClassOf obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ] . obo:SCDO_0003028 obo:IAO_0000115 "A person's ethnic status, whether conserved or mixed ethnicity." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (curators)" ; oboInOwl:hasExactSynonym "Tribe" ; a owl:Class ; rdfs:label "Ethnic Status" ; rdfs:subClassOf obo:SCDO_0001551 . obo:SCDO_0003065 obo:IAO_0000115 "Genetic variation in the structure leading to the abnomality of protein structure in non-sickle cell disease hemoglobin." ; obo:SCDO_0000303 "Curation completed by the SCDO curator team: Clair." ; a owl:Class ; rdfs:label "obsolete Non-SCD Structural Variants" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0003572 obo:IAO_0000115 "Documents describing a medical treatment or research project, including proposed procedures, risks, and alternatives, that are to be signed by an individual, or the individual's proxy, to indicate his/her understanding of the document and a willingness to undergo the treatment or to participate in the research." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D032962" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003572" ; oboInOwl:hasDbXref "MESH:D032962" ; oboInOwl:hasExactSynonym "Consent Forms" ; a owl:Class ; rdfs:label "Consent Form" ; rdfs:subClassOf obo:SCDO_0007597 . obo:SCDO_0003675 obo:IAO_0000115 "A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003675" ; oboInOwl:hasDbXref "MESH:D020641" ; a owl:Class ; rdfs:label "Single Nucleotide Polymorphism" ; rdfs:subClassOf obo:NCIT_C17004 . obo:SCDO_0003696 obo:IAO_0000115 "A procedure in which a sample of peripheral blood is viewed under a microscope to count different circulating blood cells (red blood cells, white blood cells, platelets, etc.) and see whether the cells look normal." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Peripheral Blood Film Examination", "Peripheral Blood Smear" ; a owl:Class ; rdfs:label "Peripheral Blood Film" ; rdfs:subClassOf obo:NCIT_C79903 . obo:SCDO_0003712 obo:IAO_0000115 "A legal representation or family member of the participant gives consent on behalf of the patient." ; obo:SCDO_0000303 """Request inclusion into the Informed Consent Ontology. MESH has the term Third-party consent, but the description's not suitable.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Victoria Nembaware)" ; oboInOwl:hasExactSynonym "Third-Party Consent" ; a owl:Class ; rdfs:label "Proxy Consent" ; rdfs:subClassOf obo:NCIT_C25460 . obo:SCDO_0003736 obo:IAO_0000115 "Dynamic consent is a personalised, communication interface to enable greater participant engagement in clinical and research activities.The interface facilitates two-way communication to stimulate a more engaged, informed and scientifically literate participant population where individuals can tailor and manage their own consent preferences. It has the potential to be applied more broadly to situations where there are multiple and varied uses of data requiring different kinds of consent over a period of time." ; obo:SCDO_0000303 "Request inclusion into ICO below \"Informed Consent\"." ; obo:SCDO_0000340 "https://www.nature.com/articles/ejhg201471" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Dynamic Consent" ; rdfs:subClassOf obo:SCDO_0007087 . obo:SCDO_0003742 obo:IAO_0000115 "Surgical procedure involving either partial or entire removal of the spleen." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0003742" ; oboInOwl:hasDbXref "MESH:D013156" ; oboInOwl:hasExactSynonym "Splenectomies" ; a owl:Class ; rdfs:label "Splenectomy" ; rdfs:subClassOf obo:SCDO_0001133 . obo:SCDO_0003807 obo:IAO_0000115 "Hemoglobin characterized by structural alterations within the molecule that confer an inherited health condition phenotype. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains." ; obo:SCDO_0000303 """Suggest HPO to update their term description and to move terms related to hemoglobin concentration below \"Abnormal Hemoglobin Concentration\". Include as a sub-class \"Hemoglobin S-Providence\"?""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; dc:source obo:HP_0011902 ; oboInOwl:hasExactSynonym "Abnormal Hemoglobin Variant", "Abnormal Hemoglobins", "Abnormal Variant of Hemoglobin" ; a owl:Class ; rdfs:label "Abnormal Hemoglobin" ; rdfs:subClassOf obo:HP_0001877, obo:SCDO_0006921 . obo:SCDO_0003894 obo:IAO_0000115 "The polymerase chain reaction (PCR) is the most common method to detect the deletional thalassaemias. Gap-PCR amplifies the deleted DNA sequence using the primers flanking the deleted region 10. Three primers are designed for each deletion to amplify the normal (undeleted) and deleted gene sequences." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "Kho SL, Chua KH, George E, Tan JA. A novel gap-PCR with high resolution melting analysis for the detection of α-thalassaemia Southeast Asian and Filipino β°-thalassaemia deletion. Sci Rep. 2015;5:13937. Published 2015 Sep 14. doi:10.1038/srep13937" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Gap PCR" ; rdfs:subClassOf obo:SCDO_0000913 . obo:SCDO_0004061 obo:IAO_0000115 "The genetic constitution of the individual, comprising the alleles present at each genetic locus." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004061" ; oboInOwl:hasDbXref "MESH:D005838" ; a owl:Class ; rdfs:label "Genotype" ; rdfs:subClassOf obo:SCDO_0000765 . obo:SCDO_0004078 obo:IAO_0000115 "Characterized by an established ileus, with vomiting, a silent distended abdomen and distended bowel loops and fluid levels on abdominal x-ray. Some hepatic enlargement is common, and it is often associated with bilateral basal lung consolidation (chest syndrome)." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Can be treated with analgesia, IV fluids, and antibiotics if patient is febrile.""" ; obo:SCDO_0000340 , "SCD Management guidelines - Tanzania" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Mesenteric Syndrome" ; a owl:Class ; rdfs:label "Girdle Syndrome" ; rdfs:subClassOf obo:HP_0000118, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:SCDO_0004139 obo:IAO_0000115 "The most common and normal adult human hemoglobin tetramer, comprising over 97% of the total red blood cell hemoglobin and consisting of two alpha chains and two beta chains." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\". Suggest update to description in MESH.""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasDbXref "MESH:D006441" ; oboInOwl:hasExactSynonym "Adult Haemoglobin", "Haemoglobin A", "Haemoglobin A1", "Hb A", "HbA", "Hemoglobin A", "Hemoglobin A1", "alpha2beta2" ; a owl:Class ; rdfs:label "Adult Hemoglobin" ; rdfs:subClassOf obo:SCDO_0006835 . obo:SCDO_0004187 obo:IAO_0000115 "May be caused by an acute VOC, malarial infection or oxidant drug exposure in individuals with concomitant glucose-6-phosphate dehydrogenase (G6PD) deficiency. Haemolytic crisis may be distinguished from aplastic crisis by the finding of a reticulocytosis as opposed to a reticulocytopenia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "SCD Management guidelines - South Africa" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Hemolytic Crisis" ; rdfs:subClassOf obo:HP_0001871, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ] . obo:SCDO_0004277 obo:IAO_0000115 "A term used to express willingness to participate in research by persons who are by definition too young to give informed consent but who are old enough to understand the proposed research in general, its expected risks and possible benefits, and the activities expected of them as subjects." ; obo:SCDO_0000303 "The source term seems to be deprecated in the ICO." ; obo:SCDO_0000340 obo:ICO_0000143 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "ICO:0000143" ; a owl:Class ; rdfs:label "Assent" ; rdfs:subClassOf obo:SCDO_0007597 . obo:SCDO_0004444 obo:IAO_0000115 "The protein product of the fusion of the gene products of the HBD and HBB genes that causes the mutation which causes the Hemoglobin Lepore Trait." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Crossover between delta and beta globin gene loci", "Delta Beta Globin Chain Fusion Product" ; a owl:Class ; rdfs:label "Delta Beta Globin Fusion Chain" ; rdfs:subClassOf obo:SCDO_1000012 . obo:SCDO_0004576 obo:IAO_0000115 "Chronic splenic sequestration associated with enlarged spleen and cytopaenia with anaemia and reduction in white blood cells and platelets. The anaemia is usually chronic in nature and patients rarely present with signs of heart failure." ; obo:SCDO_0000303 "Request inclusion into the HPO below \"Hypersplenism\"." ; obo:SCDO_0000340 "Management of Sickle Cell Disease - The United Republic of Tanzania (By Ministry of Health)" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Chronic Hypersplenism" ; rdfs:subClassOf obo:SCDO_0001334, obo:SCDO_0006905, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0004598 obo:IAO_0000115 "The sequential set of three nucleotides in transfer RNA that interacts with its complement in messenger RNA, the Codon, during translation in the ribosome." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000926" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004598" ; oboInOwl:hasDbXref "MESH:D000926" ; a owl:Class ; rdfs:label "Anticodon" ; rdfs:subClassOf obo:SCDO_0005593 . obo:SCDO_0004623 obo:IAO_0000115 "Also known as sense codon, a set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (terminator codon). Most codons are universal, but some organisms do not produce the transfer RNAs complementary to all codons. These codons are referred to as unassigned codons (nonsense codons)." ; obo:SCDO_0000303 "Add \"Terminator Codon\" as a parent of \"Nonsense Codon\" as in MESH?" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D003062" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004623" ; oboInOwl:hasDbXref "MESH:D003062" ; a owl:Class ; rdfs:label "Codon" ; rdfs:subClassOf obo:SCDO_0005593 . obo:SCDO_0004716 obo:IAO_0000115 "A codon that directs initiation of protein translation (Translation, Genetic) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D018387" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004716" ; oboInOwl:hasDbXref "MESH:D018387" ; oboInOwl:hasExactSynonym "Codon, Initiation", "Codon, Initiator", "Initiation Codon", "Initiation Codons", "Initiator Codons", "Start Codon", "Start Codons" ; a owl:Class ; rdfs:label "Initiator Codon" ; rdfs:subClassOf obo:SCDO_0004623 . obo:SCDO_0004829 obo:IAO_0000115 "Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic)." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_0003764" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004829" ; oboInOwl:hasDbXref "EFO:0003764" ; oboInOwl:hasExactSynonym "Mini Stroke", "TIA", "Transient Ischemic Attacks" ; a owl:Class ; rdfs:label "Transient Ischemic Attack" ; rdfs:subClassOf obo:HP_0030680, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0004836 obo:IAO_0000115 "A chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood." ; obo:SCDO_0000340 obo:OAE_0002122 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0004836" ; oboInOwl:hasDbXref "OAE:0002122" ; a owl:Class ; rdfs:label "Angina" ; rdfs:subClassOf obo:HP_0011025 . obo:SCDO_0004847 obo:IAO_0000115 "A rarely recognized complication of vaso-occlusive crisis. It is characterized by a presentation of right upper quadrant pain in the liver. A smooth, tender, enlarged liver is noted on physical exam. The lab values show a decrease in the hemoglobin/hematocrit. An increase in reticulocyte count is also seen." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Norris, W. E. (2004). Acute hepatic sequestration in sickle cell disease. Journal of the National Medical Association, 96(9), 1235-1239. The Management of Sickle Cell Disease. 1984. (Revised June 2002). NIH publication 02-2117. Available at http:/www.nhlbi.nih.gov/health/prof/blood/sickle/sc." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Acute Hepatic Sequestration" ; rdfs:subClassOf obo:HP_0001392, obo:NCIT_C115224, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0004860 obo:IAO_0000115 "'A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0002381 ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_2676" ; oboInOwl:hasDbXref "CHEBI:2676" ; a owl:Class ; rdfs:label "deprecated-Amoxicillin" ; rdfs:subClassOf obo:SCDO_1000035 ; owl:deprecated true . obo:SCDO_0004888 obo:IAO_0000115 "An acquired disorder caused by several hematological and immunological diseases and characterized by impairment of splenic function." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps below \"Abnormality of the Spleen\" in the HPO." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; dc:source "Kirkineska L, Perifanis V, Vasiliadis T. Functional hyposplenism. Hippokratia. 2014;18(1):7–11.", "Vijay, V., Cavenagh, J.D. and Yate, P., 1998. The anaesthetist's role in acute sickle cell crisis. British journal of anaesthesia, 80(6), pp.820-828." ; oboInOwl:hasExactSynonym "FH" ; a owl:Class ; rdfs:label "Functional Hyposplenism" ; rdfs:subClassOf obo:HP_0001743, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0004905 obo:IAO_0000115 "Deletion of a part of the beta-globin locus." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source ; oboInOwl:hasExactSynonym "Beta-Globin Cluster Deletion", "Beta-Globin Gene Cluster Deletion", "Hemaglobin Beta Gene Deletion" ; a owl:Class ; rdfs:label "Beta-Globin Locus Deletion" ; rdfs:subClassOf obo:NCIT_C19296 . obo:SCDO_0005167 obo:IAO_0000115 "Long lasting form of anemia." ; obo:SCDO_0000303 """Request inclusion into relevant ontology No online description for this term exists, would it be sufficient to say 'Long lasting form of anemia'? or is there a better definition specific for sickle cell anemia?""" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Chronic Anemia" ; rdfs:subClassOf obo:HP_0001903, obo:SCDO_0001334, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0005191 obo:IAO_0000115 "An increase in the rate of hemolysis, in conjunction with specific clinical complications of sickle cell disease." ; obo:SCDO_0000303 """Request inclusion into Mammalian Phenotype ontology below \"Hemolysis\". Info also provided by the definition source: 'Hyperhemolysis should be typified by an acute reduction in hemoglobin level associated with higher than usual reticulocyte counts and perhaps an unaccountable and sudden increase in LDH.'""", "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs, David J. Weatherall. Cambridge University Press, 17 Aug 2009" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Hyperhemolysis" ; rdfs:subClassOf obo:HP_0001392, obo:MP_0010163, obo:NCIT_C115224, obo:SCDO_0000895 . obo:SCDO_0005243 obo:IAO_0000115 "A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005243" ; oboInOwl:hasDbXref "MESH:D055028" ; oboInOwl:hasExactSynonym "CGH", "Comparative Genome Hybridization", "Comparative Genomic Analysis", "Comparative Genomic Hybridizations" ; a owl:Class ; rdfs:label "Comparative Genomic Hybridisation" ; rdfs:subClassOf obo:SCDO_0000448 . obo:SCDO_0005279 obo:IAO_0000115 "An abnormally high number of reticulocytes per unit volume of blood. The normal fraction of reticulocytes in the blood depends on the clinical situation but is usually 0.5% to 2.5% in adults and 2% to 6% in infants." ; obo:IAO_0100001 obo:SCDO_0001272 ; obo:SCDO_0000303 """Request inclusion into relevant ontology Symptom of splenic sequestration, or increased haemolysis.""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Reticulocyte Count High" ; a owl:Class ; rdfs:label "deprecated High Reticulocyte Count" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0005339 obo:IAO_0000115 "The physical characteristics of the globin polypeptides that form hemoglobins." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 "https://www.ncbi.nlm.nih.gov/pubmed/20339107" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Globin Chain Phenotype" ; a owl:Class ; rdfs:label "Globin Phenotype" ; rdfs:subClassOf obo:SCDO_0009613 . obo:SCDO_0005379 obo:IAO_0000115 "Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D019991" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005379" ; oboInOwl:hasDbXref "MESH:D019991" ; oboInOwl:hasExactSynonym "Data Base" ; a owl:Class ; rdfs:label "Database" ; rdfs:subClassOf obo:SCDO_0300003 . obo:SCDO_0005446 obo:IAO_0000115 "The major component of hemoglobin in the fetus. This hemoglobin has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by leukemia and several types of anemia." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\", for completion sake." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005446" ; oboInOwl:hasDbXref "MESH:D005319" ; oboInOwl:hasExactSynonym "Fetal Haemoglobin", "Foetal Haemoglobin", "Haemoglobin F", "Hb F", "HbF", "Hemoglobin F" ; a owl:Class ; rdfs:label "Fetal Hemoglobin" ; rdfs:subClassOf obo:SCDO_0006835 . obo:SCDO_0005464 obo:IAO_0000115 "A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction)." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_1001375" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005464" ; oboInOwl:hasDbXref "EFO:1001375" ; a owl:Class ; rdfs:label "Myocardial Ischemia" ; rdfs:subClassOf obo:SCDO_0000665, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:SCDO_0005580 obo:IAO_0000115 "Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterised by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty." ; obo:IAO_0100001 obo:SCDO_0000842 ; obo:SCDO_0000340 "http://www.orpha.net/ORDO/Orphanet_86820" ; oboInOwl:hasDbXref "Orphanet:86820" ; oboInOwl:hasExactSynonym "ANFH" ; a owl:Class ; rdfs:label "deprecated-Avascular Necrosis of the Femoral Head" ; rdfs:subClassOf obo:NCIT_C118385 ; owl:deprecated true . obo:SCDO_0005593 obo:IAO_0000115 "The meaning ascribed to the base sequence with respect to how it is translated into amino acid sequence. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D005815" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005593" ; oboInOwl:hasDbXref "MESH:D005815" ; a owl:Class ; rdfs:label "Genetic Code" ; rdfs:subClassOf obo:SCDO_0005722 . obo:SCDO_0005671 obo:IAO_0000115 "Deletion of the HBB and HBD genes that results in delta-beta thalassemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "HBB and HBD Deletion" ; rdfs:subClassOf obo:SCDO_0004905, obo:SCDO_1000366, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000343 ] . obo:SCDO_0005722 obo:IAO_0000115 "A biological object that contains genetic information and that is involved in transmitting genetically encoded traits from one organism to another." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0005722" ; oboInOwl:hasDbXref "MESH:D040342" ; oboInOwl:hasExactSynonym "Genetic Structures" ; a owl:Class ; rdfs:label "Genetic Structure" ; rdfs:subClassOf obo:SCDO_0000765 . obo:SCDO_0005927 obo:IAO_0000115 "An ethical principle that obligates one to treat people fairly. Distributive justice refers to allocating benefits and harms fairly; procedural justice refers to using fair processes to make decisions that affect people; formal justice refers to treating similar cases in the same way. In human subjects research, the principle of justice implies that subjects should be selected equitably." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "https://www.niehs.nih.gov/research/resources/bioethics/glossary/index.cfm#human-subjects-research" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Justice" ; rdfs:subClassOf obo:GSSO_003239 . obo:SCDO_0006000 obo:IAO_0000115 "Elevated body temperature due to failed thermoregulation, or inflammation or immune responses." ; obo:SCDO_0000303 """Merged the two descriptions from NCIT and HP Suggest update to description in NCIT and HP.""" ; obo:SCDO_0000340 obo:HP_0001945, obo:NCIT_C3038 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0001945", "NCIT:C3038" ; oboInOwl:hasExactSynonym "Pyrexia", "Pyrogenic Reaction" ; a owl:Class ; rdfs:label "Fever" ; rdfs:subClassOf obo:SCDO_0002674, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0006036 obo:IAO_0000115 "A person who has not attained the age at which full civil rights are accorded." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D033242" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006036" ; oboInOwl:hasDbXref "MESH:D033242" ; a owl:Class ; rdfs:label "Minor" ; rdfs:subClassOf obo:SCDO_0002125 . obo:SCDO_0006070 obo:IAO_0000115 "An ethnic group that includes persons with significant ethnic contributions from more than one group." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0002032" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006070" ; oboInOwl:hasDbXref "ERO:0002032" ; a owl:Class ; rdfs:label "Mixed Ethnicity" ; rdfs:subClassOf obo:SCDO_0003028 . obo:SCDO_0006339 obo:IAO_0000115 "Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012106" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006339" ; oboInOwl:hasDbXref "MESH:D012106" ; a owl:Class ; rdfs:label "Research" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_0006429 obo:IAO_0000115 "An uncommon complication of cholecystitis and refers to a situation where the gallbladder lumen is filled and distended by purulent material (pus)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "https://radiopaedia.org/articles/gallbladder-empyema" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Gallbladder Empyema" ; rdfs:subClassOf obo:HP_0025031 . obo:SCDO_0006461 obo:IAO_0000115 "Aplasia or hemolysis may be precipitated by another illness/infection in sickle cell disease patients. Acutely severe anemia is defined as Hb < 5g/dl or a recent acute drop in HB > 2g/dl below the individual's steady state value. If no steady state value is available, it can be detected by the presence of acutely symptomatic anemia (i.e. tachycardia, cardiac failure, shock)." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Please check with the working group as to how they feel about the label for this term.""" ; obo:SCDO_0000340 "SCD Management guidelines - Tanzania" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Acutely Severe Anemia" ; rdfs:subClassOf obo:HP_0001903, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ] . obo:SCDO_0006517 obo:IAO_0000115 "Research involving the collection, storage, or use of private data or biological samples from living individuals by means of interactions, interventions, surveys, or other research methods or procedures." ; obo:SCDO_0000340 "https://www.niehs.nih.gov/research/resources/bioethics/glossary/index.cfm#human-subjects-research" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; a owl:Class ; rdfs:label "Human Subject Research" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_0006589 obo:IAO_0000115 "The collecting of fetal blood samples typically via endoscopic ultrasound guided fine needle aspiration from the umbilical vein, followed by examination of the blood to detect fetal abnormalities." ; obo:SCDO_0000303 "Suggest update to description in MESH." ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D017218" ; oboInOwl:hasExactSynonym "Fetal Blood Sampling", "PUBS", "Percutaneous Umbilical Cord Blood Sampling", "Umbilical Vein Sampling" ; a owl:Class ; rdfs:label "Cordocentesis" ; rdfs:subClassOf obo:SCDO_0000505, obo:SCDO_0000919 . obo:SCDO_0006613 obo:IAO_0000115 "A material transfer agreement (MTA) is a type of legally enforceable contract employed by research institutions and companies to set the terms under which their materials and associated data may be obtained and used by others." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Henderson J (2007) Counterpoint: MTAs are a practical necessity. Nat Biotechnol 25: 722–724." ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "MTA" ; a owl:Class ; rdfs:label "Material Transfer Agreement" ; rdfs:subClassOf obo:SCDO_0300006 . obo:SCDO_0006706 obo:IAO_0000115 "A branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D001675" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006706" ; oboInOwl:hasDbXref "MESH:D001675" ; oboInOwl:hasExactSynonym "Biomedical Ethics", "Health Care Ethics" ; a owl:Class ; rdfs:label "Bioethics" ; rdfs:subClassOf obo:NCIT_C39796 . obo:SCDO_0006832 obo:IAO_0000115 "A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006832" ; oboInOwl:hasDbXref "MESH:D001206" ; oboInOwl:hasExactSynonym "Ascorbic Acid Deficiencies", "Vitamin C Deficiencies", "Vitamin C Deficiency" ; a owl:Class ; rdfs:label "Ascorbic Acid Deficiency" ; rdfs:subClassOf obo:SCDO_1000261 . obo:SCDO_0006833 obo:IAO_0000115 "A rare intracranial arteriopathy involving progressive stenosis of the cerebral vasculature located at the base of the brain causing transient ischemic attacks or strokes." ; obo:SCDO_0000340 "http://www.orpha.net/ORDO/Orphanet_2573" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006833" ; oboInOwl:hasDbXref "ORPHA:2573" ; oboInOwl:hasExactSynonym "MMD" ; a owl:Class ; rdfs:label "Moyamoya Disease" ; rdfs:subClassOf obo:SCDO_0000267, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0006835 obo:IAO_0000115 "Hemoglobin that presents no inherited health condition phenotype." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin\"." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hemoglobin Normal", "Hemoglobin Normal Variant" ; a owl:Class ; rdfs:label "Normal Hemoglobin" ; rdfs:subClassOf obo:NCIT_C16676, obo:SCDO_0009613 . obo:SCDO_0006847 obo:IAO_0000115 "An acute form of acquired red cell aplasia. A significant change in blood picture is observed, characterised by a precipitous fall in the haemoglobin level (>20 g/l beyond steady state level) and reduced (<1%) or absent reticulocytes in the peripheral blood. The total white blood cell or platelet counts may or may not be affected. In addition, there is no significant increase in the unconjugated fraction of serum bilirubin.The most common cause is infection by parvovirus B19, a DNA virus that replicates inside immature red blood cells in the bone marrow, resulting in severe anaemia (hemoglobin levels well below steady state) and low reticulocyte count. It is rarely recurrent." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Juwah, A. I., Nlemadim, E. U., & Kaine, W. (2004). Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria. Archives of disease in childhood, 89(6), 572-576.", "SCD Management guidelines - Jamaica", "SCD Management guidelines - Nigeria", "SCD Management guidelines - South Africa" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Aplastic Crises" ; a owl:Class ; rdfs:label "Aplastic Crisis" ; rdfs:subClassOf obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0006860 obo:IAO_0000115 "Mutations in the HBG1 and/or HBG2 genes. Such mutations can lead to variably increased levels of fetal hemoglobin (Hb) (Hb F, alpha2gamma2) in the syndrome of hereditary persistence of fetal Hb (HPFH)." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Perhaps add sub-classes of specific mutations as in the dc:source.""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "HBG1 and/or HBG2 Mutations" ; rdfs:subClassOf obo:IDOMAL_50000026, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000235 ] . obo:SCDO_0006905 obo:IAO_0000115 "Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_1000975" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0006905" ; dc:source "Al-Salem, A. H. (2011). Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy. ISRN Hematology, 2011, 864257. http://doi.org/10.5402/2011/864257" ; oboInOwl:hasDbXref "EFO:1000975" ; oboInOwl:hasExactSynonym "Hypersplenia" ; a owl:Class ; rdfs:label "Hypersplenism" ; rdfs:subClassOf obo:HP_0001743, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0006909 obo:IAO_0000115 "Significant change in blood picture characterised by a precipitous fall in the haemoglobin level associated with jaundice, marked reticulocytosis, and polychromasia on the blood smear, increased unconju- gated hyperbilirubinaemia, and increased urobilinogen content in urine above the steady state level for each individual patient." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Juwah, A. I., Nlemadim, E. U., & Kaine, W. (2004). Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria. Archives of disease in childhood, 89(6), 572-576." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Hyper-Hemolytic Crisis" ; rdfs:subClassOf obo:SCDO_0004187, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0006911 obo:IAO_0000115 "An ethnic group that includes persons with ethnic contributions from only one ethnic group." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (curators)" ; a owl:Class ; rdfs:label "Conserved Ethnicity" ; rdfs:subClassOf obo:SCDO_0003028 . obo:SCDO_0006921 obo:IAO_0000115 "Hemoglobin with altered structural and biochemical properties." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin\"." ; obo:SCDO_0000340 "https://www.ncbi.nlm.nih.gov/pubmed/23388674" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "Hemoglobin Variant" ; rdfs:subClassOf obo:NCIT_C16676, obo:SCDO_0009613 . obo:SCDO_0007087 obo:IAO_0000115 "Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007087" ; oboInOwl:hasDbXref "MESH:D007258" ; a owl:Class ; rdfs:label "Informed Consent" ; rdfs:subClassOf obo:NCIT_C25460 . obo:SCDO_0007161 obo:IAO_0000115 "Significant change in blood picture characterised by a precipitous fall in the haemoglobin level of at least 20 g/l and accompanied by a rapidly enlarging spleen or liver (greater than 2 cm from the steady state level) and reticulocytosis above the steady state level for each individual patient. Signs of acute circulatory insufficiency such tachypnoea, tachycardia, and hypotension may or may not be present. It is the earliest life-threatening complication seen in patients with SCD besides pneumococcal infections." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Vijay, V., Cavenagh, J.D. and Yate, P., 1998. The anaesthetist's role in acute sickle cell crisis. British journal of anaesthesia, 80(6), pp.820-828." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Acute Crisis Splenic Sequestration" ; a owl:Class ; rdfs:label "Acute Splenic Sequestration Crisis" ; rdfs:subClassOf obo:SCDO_0000895, obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0007192 obo:IAO_0000115 "A hemoglobinopathy caused by a reduced or imbalanced synthesis of a normal globin chain or by a defect in the switch between synthesis of different types of normal hemoglobin." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Abnormal Hemoglobin Synthesis", "Abnormal Synthesis Hemoglobinopathy", "Synthesis Hemoglobinopathy" ; a owl:Class ; rdfs:label "Quantitative Hemoglobinopathy" ; rdfs:subClassOf obo:SCDO_0000552 . obo:SCDO_0007212 obo:IAO_0000115 "'Other molecules are complexes which do not contain protein or RNA, including lipids, carbohydrates, etc.'" ; a owl:Class ; rdfs:label "obsolete Other Molecules" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0007281 obo:IAO_0000115 "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves." ; obo:SCDO_0000303 "Suggest update to description. Not sure if they changed their description or if we adapted it." ; obo:SCDO_0000340 obo:HP_0000846 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0000846" ; oboInOwl:hasExactSynonym "Hypoadrenalism" ; a owl:Class ; rdfs:label "Adrenal Insufficiency" ; rdfs:subClassOf obo:HP_0000834 . obo:SCDO_0007495 obo:IAO_0000115 "The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D012306" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007495" ; oboInOwl:hasDbXref "MESH:D012306" ; a owl:Class ; rdfs:label "Risk" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_0007519 obo:IAO_0000115 "A process of inclusive participation that supports mutual respect of values, strategies, and actions for authentic partnership of people affiliated by geographic location, shared interest, or similar circumstances to address issues affecting community wellbeing." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Holzer et al 2014 Doi:10.1097/JIM.0000000000000097" ; obo:SCDO_1000288 "Few but definitions not available" ; a owl:Class ; rdfs:label "Community Engagement" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_0007565 obo:IAO_0000115 "Distinct geographical area." ; obo:IAO_0100001 obo:SCDO_1000367 ; obo:SCDO_0000303 "This term was too general. Was replaced by \"Geographic Area\"." ; a owl:Class ; rdfs:label "deprecated Major Area" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0007597 obo:IAO_0000115 "Information or a description of consent (hypothetical or obtained) or any aspect involved in or captured in the consent process." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps the ICO." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Descriptor of Consent" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_0007618 obo:IAO_0000115 "In situ death of bone within the humeral head due to disruption of blood supply." ; obo:IAO_0100001 obo:SCDO_1000376 ; obo:SCDO_0000303 "Has synonym: Osteonecrosis of the humeral head" ; obo:SCDO_0000340 "http://www.wheelessonline.com/ortho/Humeral_Head_Osteonecrosis" ; a owl:Class ; rdfs:label "deprecated-Avascular necrosis of the humeral head" ; rdfs:subClassOf obo:NCIT_C118385 ; owl:deprecated true . obo:SCDO_0007623 obo:IAO_0000115 "The molecular characteristics of a cell of tissue including expressed coding and non-coding RNAs, proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." ; obo:SCDO_0000340 , "http://www.bioassayontology.org/bao#BAO_0170001" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0007623" ; oboInOwl:hasDbXref "BAO:0170001" ; a owl:Class ; rdfs:label "Molecular Phenotype" ; rdfs:subClassOf obo:OGMS_0000023 . obo:SCDO_0007624 obo:IAO_0000115 "HBB genetic variants that result in reduced or absent hemoglobin subunit beta production." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "PMID: 20301599" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Beta Thalassemia Genotype" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000107 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000240 ] . obo:SCDO_0007656 obo:IAO_0000115 "Hemolytic anemia, in which patients are compound or double heterozygous for both the sickle cell gene and a thalassemia gene." ; obo:SCDO_0000303 "Suggest update to description in NCIT" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C61237" ; oboInOwl:hasExactSynonym "Sickle Cell-Thalassemia" ; a owl:Class ; rdfs:label "Sickle Cell Thalassemia" ; rdfs:subClassOf obo:SCDO_1000163, obo:SCDO_1000215, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C79903 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0009731 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0007897 obo:IAO_0000115 "A document containing the determination of the Research Ethics Committee (REC) that the clinical study with human subject participation has been reviewed and may be conducted at a particular study site within the constraints set forth by the REC and other institutional and federal requirements. The regulations require that an REC conduct continuing review of research at intervals appropriate to the degree of risk, but not less than once a year." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Ethics Approval" ; rdfs:subClassOf obo:SCDO_0300005, obo:SCDO_1000430 . obo:SCDO_0007900 obo:IAO_0000115 "Hemoglobin produced in the blood islands in the embryonic yolk sac during the mesoblastic stage of gestation. There are four different embryonic hemoglobins, Hemoglobin Gower 1, Hemoglobin Gower 2, Hemoglobin Portland 1 and Hemoglobin Portland 2." ; obo:SCDO_0000303 """Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\". Add sub-classes: Hemoglobin Gower 1 Hemoglobin Gower 2 Hemoglobin Portland 1 Hemoglobin Portland 2""" ; obo:SCDO_0000340 , """R Al-Mufti, H Hambley, F Farzaneh, KH Nicolaides Haematologica Jan 2000, 85 (7) 690-693;""" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Hemoglobin Epsilon" ; a owl:Class ; rdfs:label "Embryonic Hemoglobin" ; rdfs:subClassOf obo:SCDO_0006835 . obo:SCDO_0008037 obo:IAO_0000115 "A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed. It is often associated with infections, infarctions, and severe metabolic or sickle cell complications." ; obo:SCDO_0000303 "Suggest update to description in HPO." ; obo:SCDO_0000340 obo:HP_0011145, "SCD Management guidelines - Jamaica" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0011145" ; oboInOwl:hasExactSynonym "Provoked Seizures", "Situation-Related Seizures" ; a owl:Class ; rdfs:label "Acute Symptomatic Seizure" ; rdfs:subClassOf obo:SCDO_1000000, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0008251 obo:IAO_0000115 "Deletion of both HBA1 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Trans Deletion of HBA1" ; a owl:Class ; rdfs:label "Homozygous Deletion of HBA1" ; rdfs:subClassOf obo:SCDO_0001386 . obo:SCDO_0008262 obo:IAO_0000115 "A hemoglobinopathy caused by the presence of structurally abnormal hemoglobins." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Qualitative Hemoglobinopathy" ; a owl:Class ; rdfs:label "Structural Hemoglobinopathy" ; rdfs:subClassOf obo:SCDO_0000552 . obo:SCDO_0008595 obo:IAO_0000115 "Persistence of an inflammatory event in the articulation overtime." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Chronic Arthritis" ; rdfs:subClassOf obo:HP_0001369, obo:SCDO_0001334, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ] . obo:SCDO_0008623 obo:IAO_0000115 "The obstruction of blood vessels by altered erythrocytes that can result in pain, anemia and tissue ischemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Vaso-Occlusion" ; rdfs:subClassOf obo:HP_0030680 . obo:SCDO_0008625 obo:IAO_0000115 "Characterized by pain and discomfort in the right upper quadrant (RUQ) of the abdomen caused by a number of possible aetiologies in sickle cell disease. Causes of RUQ pain may be divided into pain originating from the liver or gall bladder versus other origins of abdominal pain in that region." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "SCD Management guidelines - Jamaica" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "RUQ Pain", "Right Upper Quadrant Pain" ; a owl:Class ; rdfs:label "Right Upper Quadrant Syndrome" ; rdfs:subClassOf obo:SCDO_0000895, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ] . obo:SCDO_0008688 obo:IAO_0000115 "A biobank is a collections of samples of biological substances (e.g. tissue, blood, DNA) which are linked to data about the samples and their donors. They have a dual nature as collections of samples and data and usually require investigators or institutions to agree to certain conditions as a condition for sharing samples or data with them." ; obo:SCDO_0000303 "Suggest update to description in OMIABIS" ; obo:SCDO_0000340 obo:OMIABIS_0000000, ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "OMIABIS:0000000" ; a owl:Class ; rdfs:label "Biobank" ; rdfs:subClassOf obo:SCDO_0300003 . obo:SCDO_0008713 obo:IAO_0000115 "The concurrence of sickle cell anemia and alpha-thalassemia. This condition is thought to result in less severe hemolytic anemia due to reduced concentration of hemoglobin S and its polymerization within red blood cells." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Clair Ingram)" ; dc:source ; oboInOwl:hasExactSynonym "Co-Inheritance of Alpha-Thalassemia and Sickle Cell Anemia", "Co-Inheritance of Sickle Cell Anemia and Alpha-Thalassemia", "Sickle Cell Anemia Associated with Coexistent Alpha Thalassemia" ; a owl:Class ; rdfs:label "Sickle Cell Anemia Associated with Alpha Thalassemia" ; rdfs:subClassOf obo:SCDO_1000106, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0003894 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ] . obo:SCDO_0008778 obo:IAO_0000115 "A radiograph of dental structures made on x-ray film or stored as a digital image. The radiographs may be extraoral or intraoral. Three common types of intraoral dental images are periapical, interproximal, and occlusal radiographs." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "\"dental radiograph.\" Mosby's Medical Dictionary, 8th edition. 2009. Elsevier 7 Nov. 2018 https://medical-dictionary.thefreedictionary.com/dental+radiograph" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Radiologic Examination, Teeth" ; a owl:Class ; rdfs:label "Dental Radiograph" ; rdfs:subClassOf obo:SCDO_0000963 . obo:SCDO_0008888 obo:IAO_0000115 "The removal of excess iron from the body with special drugs." ; obo:SCDO_0000303 "Request inclusion into MESH below \"Chelation Therapy\"" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Iron Chelation Therapy" ; rdfs:subClassOf obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C95504 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000518 ] . obo:SCDO_0008925 obo:IAO_0000115 "The capacity for self-governance, i.e. the ability to make reasonable decisions." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; dc:source "https://www.hhs.gov/ohrp/sites/default/files/the-belmont-report-508c_FINAL.pdf" ; a owl:Class ; rdfs:label "Autonomy" ; rdfs:subClassOf obo:GSSO_003239 . obo:SCDO_0008937 obo:IAO_0000115 "Blockage of blood flow in the central retinal artery. Results in sudden painless loss of vision and occurs in children and young adults. Thrombus formation in the retinal artery occurs spontaneously or in association with hyphema, Moyamoya and acute chest sydrome. There is no associated pain and it may be unilateral or bilateral." ; obo:SCDO_0000303 "Suggest update to description in HPO" ; obo:SCDO_0000340 obo:HP_0025342, "SCD Management guidelines - Jamaica" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0025342" ; a owl:Class ; rdfs:label "Central Retinal Artery Occlusion" ; rdfs:subClassOf obo:HP_0030680, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0008990 obo:IAO_0000115 "Occurs where there is infarction of vertebral bone marrow, leading to collapse of the vertebrae with a typical 'fish mouth' appearance. It is often asymptomatic, but may cause acute and/or long term pain requiring analgesia and mechanical support such as a brace. Can be an acute or chronic bone problem in SCD." ; obo:SCDO_0000303 "Suggest update to description in HPO (currently no description)." ; obo:SCDO_0000340 obo:HP_0002953 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO" ; oboInOwl:hasDbXref "HP:0002953" ; oboInOwl:hasExactSynonym "Compression Fracture", "Fractures of Vertebral Bodies", "Vertebral Body Compression", "Vertebral Compression", "Vertebral Compression Fractures", "Vertebral Compression or Collapse" ; a owl:Class ; rdfs:label "Vertebral Collapse" ; rdfs:subClassOf obo:HP_0000924, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0009089 obo:IAO_0000115 "Principle dictating that harm should not come to individuals as a result of their participation in a research project." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Shamoo AE and Resnik DB, Responsible Conduct of Research, 3rd ed. (New York: Oxford University Press, 2015)." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Non-Maleficience" ; rdfs:subClassOf obo:GSSO_003239 . obo:SCDO_0009117 obo:IAO_0000115 "A nutritional condition produced by a deficiency of folic acid in the diet." ; obo:SCDO_0000340 ; obo:SCDO_0000661 "Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives." ; obo:SCDO_0000662 "This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009117" ; dc:source ; oboInOwl:hasDbXref "EFO:0001070" ; oboInOwl:hasExactSynonym "Deficiency of Folic Acid", "Deficiency of Folic Acid (Disorder)", "Folic Acid Deficiencies", "Folic Acid Deficiency" ; a owl:Class ; rdfs:label "Folate Deficiency" ; rdfs:subClassOf obo:SCDO_1000261 . obo:SCDO_0009169 obo:IAO_0000115 "A hemoglobinopathy caused by compound heterozygous inheritance of one hemoglobin S allele and one hemoglobin allele that produces structurally abnormal hemoglobin." ; obo:SCDO_0000340 ; a owl:Class ; rdfs:label "obsolete Sickle Plus Structural Variant" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0009279 obo:IAO_0000115 "Hemoglobin with decreased solubility in the red cell due to substitutions in the primary sequence of globin which alters the tertiary or quaternary structure of the molecule and results in a globin polypeptide/hemoglobin tetramer that is unstable and precipitates intracellularly, reducing the red blood cell lifespan." ; obo:SCDO_0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Unstable Hemoglobin" ; rdfs:subClassOf obo:SCDO_0003807 . obo:SCDO_0009350 obo:IAO_0000115 "An acute condition of intrasplenic pooling of large amounts of blood." ; obo:SCDO_0000303 "Suggest update to description in the Radiology Lexicon, or use their description \"Splenic sequestration occurs in sickle cell disease when sickled red blood cells become trapped in the spleen, causing it to enlarge.\"" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Blood Trapped in the Spleen" ; a owl:Class ; rdfs:comment "Can cause severely acute anemia." ; rdfs:label "Splenic Sequestration" ; rdfs:subClassOf obo:HP_0001743, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000202 ; owl:someValuesFrom obo:SCDO_0008623 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001923 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:SCDO_0009445 obo:IAO_0000115 "A complication of kidney diseases characterized by cell death involving kidney papilla in the kidney medulla. Damages to this area may hinder the kidney to concentrate urine resulting in polyuria. Sloughed off necrotic tissue may block kidney pelvis or ureter. Necrosis of multiple renal papillae can lead to kidney failure." ; obo:SCDO_0000340 "http://www.ebi.ac.uk/efo/EFO_1001004" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009445" ; oboInOwl:hasDbXref "EFO:1001004" ; oboInOwl:hasExactSynonym "Kidney Papillary Necrosis", "Necrotising Renal Papillitis", "Necrotizing Renal Papillitis", "Papillary Necrosis", "Papillary Necrosis (Disorder)", "Renal Papillitis Necrotizing" ; a owl:Class ; rdfs:label "Renal Papillary Necrosis" ; rdfs:subClassOf obo:HP_0000077, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SCDO_0009488 obo:IAO_0000115 "'Any single chemical entity that is an electrically neutral entity consisting of more than one atom. Each atom carries a certain number of electrons that orbit around the nucleus.[Curator team: []]'" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/CHEBI_25367" ; oboInOwl:hasDbXref "CHEBI:25367" ; a owl:Class ; rdfs:label "obsolete Molecule" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0009532 obo:IAO_0000115 "Effort made to secure the well-being of persons, maximizing possible benefits and minimizing possible harms." ; obo:SCDO_0000340 "https://www.hhs.gov/ohrp/sites/default/files/the-belmont-report-508c_FINAL.pdf" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO" ; oboInOwl:hasDbXref "MESH:D026686" ; a owl:Class ; rdfs:label "Beneficence" ; rdfs:subClassOf obo:GSSO_003239 . obo:SCDO_0009613 obo:IAO_0000115 "The physical characteristics and levels of proteins that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." ; obo:SCDO_0000303 """Request inclusion into BioAssay Ontology below \"biochemical phenotype\". Can all sub-classes of the \"Gene Product\" class not be included here? Can this class not be removed but its sub-classes kept?""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Protein Phenotype" ; rdfs:subClassOf obo:SCDO_0009884 . obo:SCDO_0009620 obo:IAO_0000115 "An abnormally low number of reticulocytes per unit volume of blood." ; obo:IAO_0100001 obo:SCDO_0001423 ; obo:SCDO_0000303 """Request inclusion into relevant ontology Symptom of aplastic crisis, possibly due to parvovirus B19 infection. Is there a certain value below which is considered a low reticulocyte count?""" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "deprecated Low Reticulocyte Count" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0009635 obo:IAO_0000115 "'The aplastic crisis is temporary cessation of red cell production. This usually affect sickle cell patients, because of the markedly shortened red cell survival time in patients with sickle cell disease, a precipitous drop in hemoglobin occurs in the absence of adequate reticulocytosis. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0006847 ; obo:SCDO_0000340 "http://www.ihtc.org/medical-professionals/blood-disorders/sickle-cell-disease/aplastic-crisis-intervention/" ; a owl:Class ; rdfs:label "deprecated Aplastic Crises" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_0009664 obo:IAO_0000115 "Pain resulting from tissue ischemia as a result of blockage of mesenteric blood vessels." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Akingbola TS, Kolude B, Aneni EC, et al. ABDOMINAL PAIN IN ADULT SICKLE CELL DISEASE PATIENTS: A NIGERIAN EXPERIENCE. Annals of Ibadan Postgraduate Medicine. 2011;9(2):100-104.", "SCD Management guidelines - Tanzania" ; obo:SCDO_0000662 "Abdominal distension with generalised abdominal tenderness (no rebound tenderness) and reduced bowel sounds. Abdomen moves with respiration. Vomiting/diarrhoea are not common." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Abdominal Vaso-Occlusive Crisis" ; rdfs:subClassOf obo:SCDO_0001229, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000153 ] . obo:SCDO_0009731 obo:IAO_0000115 "A mutation in the beta-globin gene, HBB, that causes decreased or absent beta-globin synthesis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Beta Thalassemia Mutation" ; rdfs:subClassOf obo:IDOMAL_50000026, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000114 ] . obo:SCDO_0009786 obo:IAO_0000115 "A genetic mutation in the HBB gene that results in absent or decreased hemoglobin subunit beta or an abnormal hemoglobin other than Hb S." ; obo:SCDO_0000303 "Too specific to SCD to be included in other ontologies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Other HBB Variants" ; rdfs:subClassOf obo:SCDO_1000038 . obo:SCDO_0009884 obo:IAO_0000115 "The proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0009884" ; oboInOwl:hasDbXref "BAO:0170003" ; a owl:Class ; rdfs:label "Biochemical Phenotype" ; rdfs:subClassOf obo:SCDO_0007623 . obo:SCDO_0010000 obo:IAO_0000115 "'Genotypes which are not specific to sickle cell trait.'" ; a owl:Class ; rdfs:label "obsolete Other Genotypes" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_0300002 obo:IAO_0000115 "The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D032984" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0300002" ; oboInOwl:hasDbXref "MESH:D032984" ; a owl:Class ; rdfs:label "Research Ethics" ; rdfs:subClassOf obo:NCIT_C39796, obo:SCDO_0300005 . obo:SCDO_0300003 obo:IAO_0000115 "Specific genre of publication." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D052180" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0300003" ; oboInOwl:hasDbXref "MESH:D052180" ; a owl:Class ; rdfs:label "Publication Formats" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_0300004 obo:IAO_0000115 "Types and formulations of studies used in epidemiological and clinical research." ; obo:SCDO_0000303 "Suggest update to description in MESH" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016020" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D016020" ; a owl:Class ; rdfs:label "Epidemiologic Study Characteristics" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_0300005 obo:IAO_0000115 "Elements, types, descriptions and formulations of a research study." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Gaston K. Mazandu)" ; a owl:Class ; rdfs:label "Research Characteristics" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_0300006 obo:IAO_0000115 "Revealing of information, by oral or written communication." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D030881" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0300006" ; oboInOwl:hasDbXref "MESH:D030881" ; a owl:Class ; rdfs:label "Information Disclosure" ; rdfs:subClassOf obo:SCDO_0002125 . obo:SCDO_0300007 obo:IAO_0000115 "Reporting to parents or guardians about care to be provided to a minor (minors)." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D035622" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0300007" ; oboInOwl:hasDbXref "MESH:D035622" ; a owl:Class ; rdfs:label "Parental Notification" ; rdfs:subClassOf obo:SCDO_0300006 . obo:SCDO_0300008 obo:IAO_0000115 "A legal requirement that designated types of information acquired by professionals or institutions in the course of their work be reported to appropriate authorities." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D019221" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0300008" ; oboInOwl:hasDbXref "MESH:D019221" ; a owl:Class ; rdfs:label "Mandatory Reporting" ; rdfs:subClassOf obo:SCDO_0300006 . obo:SCDO_0300009 obo:IAO_0000115 "Making information permanently non-identifiable that is associated with the identity of specific entities via encryption or other methods." ; obo:SCDO_0000303 "Suggest update to description in MESH" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D000068240" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D000068240" ; oboInOwl:hasExactSynonym "Data De-Identification", "Data Masking", "De-Identification" ; a owl:Class ; rdfs:label "Data Anonymization" ; rdfs:subClassOf obo:SCDO_0002125 . obo:SCDO_1000000 obo:IAO_0000115 "An observable characteristic of disease that has a severe and rapid onset of symptoms with short duration." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/NCIT_C14140", "http://semanticscience.org/resource/SIO_010056" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "Acute Phenotype" ; rdfs:subClassOf obo:HP_0000118 . obo:SCDO_1000001 obo:IAO_0000115 "A unique identifier generated either manually or electronically when adding a subject to a study." ; obo:IAO_0100001 obo:SCDO_1000469 ; a owl:Class ; rdfs:label "deprecated Research Subject ID" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000003 obo:IAO_0000115 "Records the slider label used by REDCap for a data element that uses a slider to collect data." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:label "has slider label" . obo:SCDO_1000004 obo:IAO_0000115 "Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys." ; obo:SCDO_0000303 "Could this and it's sub-classes not fall below any of the other main Therapeutics classes? Symptomatic?" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D017582" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000004" ; oboInOwl:hasDbXref "MESH:D017582" ; a owl:Class ; rdfs:label "Renal Replacement Therapy" ; rdfs:subClassOf obo:SCDO_0001129, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000084 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0009045 ] . obo:SCDO_1000005 obo:IAO_0000115 "A relationship between a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy) and a disease modifier, where the condition, entity or process is modified by the disease modifier in some way." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "modified by" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000007 obo:IAO_0000115 "An abnormal hemoglobin caused by various point mutations within the HBB gene. This form of hemoglobin prevents red blood cells from carrying oxygen effectively. There are at least 8 different types of hemoglobin D." ; obo:SCDO_0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"." ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Haemoglobin D", "Hb D", "HbD" ; a owl:Class ; rdfs:label "Hemoglobin D" ; rdfs:subClassOf obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000108 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000113 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000115 ] . obo:SCDO_1000008 obo:IAO_0000115 "A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha, beta or gamma chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis." ; obo:SCDO_0000303 """Suggest update to description in MESH (to include \"gamma chains\") Suggest this term replaces \"Methemoglobinemia\" below \"Abnormal Hemoglobin\" in the HPO.""" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006449" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "MESH:D006449" ; oboInOwl:hasExactSynonym "Hb M", "HbM Hemoglobin" ; a owl:Class ; rdfs:label "Hemoglobin M" ; rdfs:subClassOf obo:SCDO_0003807 . obo:SCDO_1000009 obo:IAO_0000115 "An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations." ; obo:SCDO_0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\", for the sake of completion." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D006446" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000009" ; oboInOwl:hasDbXref "MESH:D006446" ; oboInOwl:hasExactSynonym "Hb E" ; a owl:Class ; rdfs:label "Hemoglobin E" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000042 ] . obo:SCDO_1000010 obo:IAO_0000115 "A group of disorders caused by large deletions of the beta-globin gene complex; typically 30% fetal haemoglobin." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "HPFH-Sickle Cell Disease Syndrome", "Hereditary Persistence of Fetal Hemoglobin-Sickle Cell Disease Syndrome", "Sickle Cell Disease Syndrome-Hereditary Persistence of Fetal Hemoglobin", "Sickle Cell Disease-S/Persistence of Fetal Hemoglobin", "Sickle Cell-Hereditary Persistence of Fetal Hemoglobin" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S/HPFH" ; rdfs:subClassOf obo:SCDO_1000163, obo:SCDO_1000215, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0003894 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000069 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0006860 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001744 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0010885 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:HP_0011904 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ] . obo:SCDO_1000012 obo:IAO_0000115 "Members of the beta-globin family. In humans, they are encoded in a gene cluster on chromosome 11. They include hemoglobin subunit epsilon, hemoglobin subunit gamma, hemoglobin subunit delta and hemoglobin subunit beta. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult hemoglobin is comprised of two alpha globin chains and two beta-globin chains." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000012" ; oboInOwl:hasDbXref "MESH:D055544" ; oboInOwl:hasExactSynonym "Beta-Globins" ; a owl:Class ; rdfs:label "Beta-Globin Family Members" ; rdfs:subClassOf obo:SCDO_0005339, obo:SCDO_1000104 . obo:SCDO_1000013 obo:IAO_0000115 "This gene encodes the hemoglobin subunit beta and is located on chromosome 11 mapped at 11p15.5." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasDbXref "NCBIGene:3043" ; oboInOwl:hasExactSynonym "Beta-Globin Gene", "HBB Gene", "HBB1", "Hemoglobin Beta Gene", "Hemoglobin Beta Locus", "Hemoglobin Subunit Beta Gene" ; a owl:Class ; rdfs:label "HBB" ; rdfs:subClassOf obo:SCDO_1000362 . obo:SCDO_1000014 obo:IAO_0000115 "This gene encodes the hemoglobin subunit delta, which is a component of hemoglobin A2, which plays a role in the transport of oxygen to tissues of the adult body, but exists only in small amounts in all adult humans (1.5-3.1% of all hemoglobin molecules)." ; obo:SCDO_0000303 "Suggest update to description in NCIT" ; obo:SCDO_0000340 , "http://purl.obolibrary.org/obo/NCIT_C84961" ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C84961" ; oboInOwl:hasExactSynonym "HBD Gene", "Hemoglobin Delta Gene", "Hemoglobin Subunit Delta Gene" ; a owl:Class ; rdfs:label "HBD" ; rdfs:subClassOf obo:SCDO_1000362 . obo:SCDO_1000015 obo:IAO_0000115 "A relationship between a disease modifier and a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy), where the disease modifier modifies the condition, entity or process in some way." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "modifies" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000016 obo:IAO_0000115 "An abnormal hemoglobin that results from the substitution of glutamic acid with lysine at position 121 of the beta chain." ; obo:SCDO_0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"." ; obo:SCDO_0000340 "MESH and Zimmerman SA. Am J Hematol. 1999 Apr; 60(4) 279-84" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Hb O-Arab", "Hb-Arab", "Hemoglobin-Arab" ; a owl:Class ; rdfs:label "Hemoglobin O-Arab" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000040 ] . obo:SCDO_1000017 obo:IAO_0000115 "A material processing technique that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury or to help improve bodily function or appearance." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/ERO_0000378" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000017" ; oboInOwl:hasDbXref "ERO:0000378" ; a owl:Class ; rdfs:label "Surgery" ; rdfs:subClassOf obo:SCDO_0001133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1188 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000815 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000962 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001260 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001342 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001920 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002138 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002164 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002170 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002341 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002650 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002653 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002665 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002808 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003302 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003418 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0009830 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0010628 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0010885 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0011868 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0011886 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0012203 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0030049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0030127 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0100774 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C115319 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:OBI_1110053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000454 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000656 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000840 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001168 ] . obo:SCDO_1000018 obo:IAO_0000115 "A relation between a type of treatment or a specific treatment and a condition (phenotype or disease), where the type of treatment or specific treatment treat the condition." ; obo:SCDO_0000303 "If required later, specify as inverse of \"treated with\"." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "treats" . obo:SCDO_1000020 obo:IAO_0000115 "Treatment of factors associated with the definitive onset of a disease, illness, accident, behavioral response, or course of action. Usually one factor is more important or more obviously recognizable than others, if several are involved, and one may often be regarded as necessary. Examples include exposure to specific disease; amount or level of an infectious organism, drug, or noxious agent, etc." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D015985" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Management of Precipitating Factors", "Management of Underlying Cause", "Treatment of Underlying Cause" ; a owl:Class ; rdfs:label "Treatment of Precipitating Factors" ; rdfs:subClassOf obo:SCDO_0001152, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:DOID_1188 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000084 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000096 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000099 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000123 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000815 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000823 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000843 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000952 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000961 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000967 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0000980 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001271 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001298 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001511 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001789 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0001970 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002157 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002829 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0002955 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003198 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003418 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0003641 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0007340 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0009830 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0010628 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0011001 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:HP_0012282 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:MP_0001762 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:MP_0001792 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C115319 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:NCIT_C26702 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000037 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000265 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000465 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000743 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000796 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000797 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000828 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000839 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000851 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000932 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0000986 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001105 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_0001168 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SCDO_1000224 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000018 ; owl:someValuesFrom obo:SYMP_0019161 ] . obo:SCDO_1000023 obo:IAO_0000115 "'Every annotation must be attributed to a source, which may be a literature reference, another database or a computational analysis. The annotation must indicate what kind of evidence is found in the cited source to support the association between the gene product and the GO term. A simple controlled vocabulary is used to record evidence; and the evidence codes are simply the three-letter codes used to signify the type of evidence cited. [Curator team: Exact []]'" ; obo:SCDO_0000303 "The information in this class and its sub-classes will be migrated to evidence code properties." ; obo:SCDO_0000340 "http://www.geneontology.org/faq/what-evidence-code" ; a owl:Class ; rdfs:label "obsolete Evidence Code" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000024 obo:IAO_0000115 "'Used for annotations that depend directly on computation or automated transfer of annotations from a database, particularly when the analysis is performed internally and not published. A key feature that distinguishes this evidence code from others is that it is not made by a curator; use IEA when no curator has checked the specific annotation to verify its accuracy. [Curator team: Exact []]'" ; obo:SCDO_0000340 "http://geneontology.org/page/automatically-assigned-evidence-codes" ; a owl:Class ; rdfs:label "obsolete IEA (inferred from electronic annotation)" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_1000025 obo:IAO_0000115 "'This should be used for information extracted from articles in the medical literature. [Curator team: []]'" ; a owl:Class ; rdfs:label "obsolete PCS (published clinical study)" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_1000026 obo:IAO_0000115 "'Can be used for annotations based on individual clinical experience. [Curator team: []]'" ; a owl:Class ; rdfs:label "obsolete ICE (individual clinical experience)" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_1000027 obo:IAO_0000115 "'Not described [Curator team: []]'" ; a owl:Class ; rdfs:label "obsolete ITM (inferred by text-mining)" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_1000028 obo:IAO_0000115 "'Usually reviews or disease entries (e.g. OMIM) that only refers to the original publication. [Curator team: []]'" ; a owl:Class ; rdfs:label "obsolete TAS (traceable author statement)" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_1000029 obo:IAO_0000115 "'used in all cases where the author makes a statement that a curator wants to capture but for which there are neither results presented nor a specific reference cited in the source used to make the annotation. [Curator team: []]'" ; obo:SCDO_0000340 "http://www.geneontology.org/page/nas-non-traceable-author-statement" ; a owl:Class ; rdfs:label "obsolete NAS (non-traceable author statement)" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_1000030 obo:IAO_0000115 "'Used for those cases where an annotation is not supported by any direct evidence, but can be reasonably inferred by a curator from other annotations, for which evidence is available. [Curator team: []]'" ; obo:SCDO_0000340 "http://www.geneontology.org/page/ic-inferred-curator" ; a owl:Class ; rdfs:label "obsolete IC (inferred by curator)" ; rdfs:subClassOf obo:SCDO_1000023 ; owl:deprecated true . obo:SCDO_1000031 obo:IAO_0000115 "Terms deprecated in the \"Personal Attribute\" class." ; a owl:Class ; rdfs:label "from personal attribute" ; rdfs:subClassOf obo:SCDO_0000359 . obo:SCDO_1000032 obo:IAO_0000115 "A diagnostic instrument, technique, laboratory assay or test, or method of patient examination used for differential diagnosis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Diagnostic Tool" ; rdfs:subClassOf obo:SCDO_0000379 . obo:SCDO_1000033 obo:IAO_0000115 "A research instrument consisting of a series of questions and other prompts for the purpose of gathering information from respondents to assist with differential diagnosis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Questionnaire" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Diagnostic Questionnaire" ; a owl:Class ; rdfs:label "Diagnostic Instrument" ; rdfs:subClassOf obo:SCDO_1000032 . obo:SCDO_1000034 obo:IAO_0000115 "Terms deprecated in the \"Diagnostics\" class." ; a owl:Class ; rdfs:label "from diagnostics" ; rdfs:subClassOf obo:SCDO_0000359 . obo:SCDO_1000035 obo:IAO_0000115 "Terms deprecated in the \"Therapeutics\" class." ; a owl:Class ; rdfs:label "from therapeutics" ; rdfs:subClassOf obo:SCDO_0000359 . obo:SCDO_1000036 obo:IAO_0000115 "When the abnormal hemoglobin, hemoglobin C (HbC), has been detected in a blood sample." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin C Present", "Haemoglobin C in Blood", "HbC Present", "HbC in Blood", "Hemoglobin C in Blood" ; a owl:Class ; rdfs:label "Hemoglobin C Present" ; rdfs:subClassOf obo:HP_0020061 . obo:SCDO_1000037 obo:IAO_0000115 "An abnormality of the cerebral vasculature." ; obo:SCDO_0000340 obo:HP_0100659 ; obo:SCDO_1000288 "Few but definitions not available" ; oboInOwl:hasDbXref "HP:0100659" ; oboInOwl:hasExactSynonym "Abnormality of the Cerebral Blood Vessels", "Cerebrovascular Disorder" ; a owl:Class ; rdfs:label "Abnormality of the Cerebral Vasculature" ; rdfs:subClassOf obo:HP_0002597 . obo:SCDO_1000038 obo:IAO_0000115 "A mutation wholly or partly responsible for causing a sickle cell disease." ; obo:SCDO_0000303 """Request inclusion into relevant ontology B-Thal mutations: -- http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2004.tb00278.x/pdf -- https://www.ncbi.nlm.nih.gov/pubmed/15153712""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SCD Causal Mutation" ; rdfs:subClassOf obo:IDOMAL_50000026 . obo:SCDO_1000039 obo:IAO_0000115 "The glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.bloodjournal.org/content/bloodjournal/46/3/363.full.pdf?sso-checked=true" ; obo:SCDO_1000288 "Negligable" ; oboInOwl:hasExactSynonym "Beta S Mutation", "E6V", "Glu6Val", "Sickle Cell Mutation" ; a owl:Class ; rdfs:label "HBB, GLU6VAL" ; rdfs:subClassOf obo:SCDO_1000038, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001055 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001059 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001061 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001062 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000010 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000062 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000086 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000090 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000164 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000165 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000166 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000205 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000051 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000052 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000069 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000070 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000075 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000084 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000107 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000159 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000161 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000058 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000072 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000073 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000074 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000083 ] . obo:SCDO_1000040 obo:IAO_0000115 "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation is found as a single alteration in Hemoglobin O-Arab and is one of the two contributing mutations to the production of Hemoglobin S-Oman." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Beta O-Arab Mutation", "Contributing Beta S-Oman Mutation", "Glu121Lys" ; a owl:Class ; rdfs:label "HBB, GLU121LYS" ; rdfs:subClassOf obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0000544 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0000545 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001064 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000165 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000051 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000075 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000228 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000231 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000016 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000074 ] . obo:SCDO_1000041 obo:IAO_0000115 "A mutation where the glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation results in the production of Hemoglobin C and confers resistance to malaria." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Beta C mutation", "HbC Mutation" ; a owl:Class ; rdfs:label "HBB, GLU6LYS" ; rdfs:subClassOf obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0000519 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0000520 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001059 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000166 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000049 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000225 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000232 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_0000513 ] . obo:SCDO_1000042 obo:IAO_0000115 "A mutation in the HBB gene causing substitution of glutamic acid for lysine at the 26th position of the beta-globin chain." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Beta E Mutation", "HbE Mutation" ; a owl:Class ; rdfs:label "HBB, GLU26LYS" ; rdfs:subClassOf obo:SCDO_0001765, obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0000531 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001062 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000052 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000227 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000229 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000009 ] . obo:SCDO_1000043 obo:IAO_0000115 "A person's concept of self as being male and masculine or female and feminine, or ambivalent, based in part on physical characteristics, parental responses, and psychological and social pressures. It is the internal experience of gender role." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000043" ; oboInOwl:hasDbXref "MESH:D005783" ; a owl:Class ; rdfs:label "Gender Identity" ; rdfs:subClassOf obo:NCIT_C19332 . obo:SCDO_1000044 obo:IAO_0000115 "A mutation where the aspartic acid in position 73 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation is found as a single alteration in Hemoglobin Korle Bu and is one of the two contributing mutations to the production of Hemoglobin C-Harlem." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://www.bloodjournal.org/content/bloodjournal/46/3/363.full.pdf?sso-checked=true" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Asp73Asn", "D73N" ; a owl:Class ; rdfs:label "HBB, ASP73ASN" ; rdfs:subClassOf obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000062 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000205 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000058 ] . obo:SCDO_1000045 obo:IAO_0000115 "A mutation where the valine in position 23 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. When compounded with the HbS mutation in the same gene, the sickling Hemoglobin S-Antilles is produced." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Contributing Beta S-Antilles Mutation", "Contributing Hb S-Antilles Mutation" ; a owl:Class ; rdfs:label "HBB, VAL23ILE" ; rdfs:subClassOf obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000166 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000073 ] . obo:SCDO_1000046 obo:IAO_0000115 "A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. This mutation is found as a single alteration in Hemoglobin Quebec-Chori. Compound heterozygosity for Hb Quebec-chori and Hb S results in sickle cell disease." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "Witkowska, H. E., Lubin, B. H., Beuzard, Y., Baruchel, S., Esseltine, D. W., Vichinsky, E. P., Kleman, K. M., Bardakdjian-Michau, J., Pinkoski, L., Cahn, S., Roitman, E., Green, B. N., Falick, A. M., Shackleton, C. H. L. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. New Eng. J. Med. 325: 1150-1154, 1991." ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hb Quebec-Chori Mutation" ; a owl:Class ; rdfs:label "HBB, THR87ILE" ; rdfs:subClassOf obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000086 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000084 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000085 ] . obo:SCDO_1000047 obo:IAO_0000115 "A mutation where the leusine residue in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by phenylalanine. This mutation on its own produces a stable hemoglobin that does not result in hemolysis (Hb Rockford), but when in combination with the Hb S mutation (HBB, GLU6VAL), the symptomatic Hb Jamaica Plain is produced." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "Perrault, J., Fairbanks, V. F., McCormick, D. J., Kubik, K., Madden, B. J., Holmes, M. W., Hoyer, J. D. Hemoglobin Rockford, beta68(E12)leu-to-phe: a new HB variant associated with mild anemia. (Abstract) Blood 90 (Suppl. 1): 30b, 1997." ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Contributing Hb Jamaica Plain Mutation" ; a owl:Class ; rdfs:label "HBB, LEU68PHE" ; rdfs:subClassOf obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000164 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000072 ] . obo:SCDO_1000048 obo:IAO_0000115 "The alleles, or variant forms of the HBB gene, that are carried by an SCD sufferer." ; obo:SCDO_0000303 """Probably too specific to be included in other ontologies. Paper mentioning haplotypes and severity: -- https://www.nature.com/scitable/topicpage/sickle-cell-anemia-a-look-at-global-8756219 -- -- Table of SCD Genotypes: -- http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2004.tb00278.x/pdf -- -- HBB allelic variants: -- https://www.omim.org/entry/141900#0243 -- -- Perhaps have parent class Hemoglobinopathy Genotype, with Hemoglobinopathy Trait below that?""" ; obo:SCDO_0000340 "http://www.nature.com/scitable/definition/genotype-234" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Sickle Cell Disease Genotype", "Sickle Genotype" ; a owl:Class ; rdfs:label "SCD Genotype" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ] . obo:SCDO_1000049 obo:IAO_0000115 "The genotype when an individual has the Hb C gene from one parent and the Hb S gene from the other. Individuals with Hb SC have similar symptoms to individuals with Hb SS, however, the anemia is less severe." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Haemoglobin Genotype SC", "SC Genotype", "beta6Glu>Val/beta6Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype SC" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0001059 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000513 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ] . obo:SCDO_1000050 obo:IAO_0000115 "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin D-Punjab (HBB Glu121Gln) variants." ; obo:SCDO_0000303 "Hemoglobin Genotype S/D-Punjab" ; obo:SCDO_0000340 "Torres LS, Okumura JV, Silva DG, Bonini-Domingos CR. Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis. Rev Bras Hematol Hemoter. 2015;37(2): 120–126. pmid:25818823" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype S/D-Punjab", "S/D-Punjab Genotype", "beta6Glu>Val/beta121Glu>Gln" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/D-Punjab" ; rdfs:subClassOf obo:SCDO_1000054, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0001061 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000528 ] . obo:SCDO_1000051 obo:IAO_0000115 "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin O-Arab (HBB GluU121Lys) variants." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Lancet. 2010 Dec 11;376(9757):2018-31. doi: 10.1016/S0140-6736(10)61029-X. Epub 2010 Dec 3." ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype S/OArab", "S/O-Arab Genotype", "beta6Glu>Val/beta121Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/O-Arab" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0001064 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000040 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000016 ] . obo:SCDO_1000052 obo:IAO_0000115 "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin E (HBB Glu26Lys) variants." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Lancet. 2010 Dec 11;376(9757):2018-31. doi: 10.1016/S0140-6736(10)61029-X. Epub 2010 Dec 3." ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype SE", "SE Genotype", "SE Hemoglobin Genotype", "beta6Glu>Val/beta26Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype SE" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0001062 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000009 ] . obo:SCDO_1000053 obo:IAO_0000115 "The homozygous genotype that involves a substitution of glutamic acid for a valine at position 6 of beta-globin chains produced by both beta-globin gene (HBB) alleles." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype SS", "Hemoglobin S Genotype", "SS Genotype", "beta6Glu>Val/beta6Glu>Val" ; a owl:Class ; rdfs:label "Hemoglobin Genotype SS" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ] . obo:SCDO_1000054 obo:IAO_0000115 "Compound heterozygous inheritance of Hb S and Hb D mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb D generally results from substitution of glutamic acid for glutamine at beta-121 (beta121Glu>Gln); such as the Hb D-Punjab/Hb D-Los Angeles variants. There are several other Hb D variants, including Hb D-Iband where threonine is substituted by lysine at beta-87 (beta87Thr>Lys) and Hb D-Iran where glutamic acid is substituted by glutamine at beta-22 (beta22Glu>Gln)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype SD", "SD Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype SD" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C155310 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000108 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000113 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000056 obo:IAO_0000115 "Compound heterozygous inheritance of Hb S and Hb C-Harlem mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb C-Harlem involves two substitutions in each beta-chain: the first being identical to that found in Hb S, and the second being a substitution of aspartic acid at position 73 by asparagine (beta73Asp>Asn)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "PMID: 1148394" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype S/C-Harlem", "S/C-Harlem Genotype", "beta6Glu>Val/beta6Glu>Val, beta73Asp>Asn" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/C-Harlem" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_1000062 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000044 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000058 ] . obo:SCDO_1000058 obo:IAO_0000115 "An abnormal hemoglobin in which two mutations occur in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the aspartic acid in position 73 is replaced by asparagine." ; obo:SCDO_0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." ; obo:SCDO_0000340 "https://www.omim.org/entry/141900#0243" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "HbS-HBC-Harlem", "Hemoglobin C-Georgetown", "Hemoglobin S-Hemoglobin C-Harlem" ; a owl:Class ; rdfs:label "Hemoglobin C-Harlem" ; rdfs:subClassOf obo:SCDO_1000082, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000044 ] . obo:SCDO_1000059 obo:IAO_0000115 "The inheritance of the gene for hemoglobin D-Punjab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Hb AD-Punjab" ; a owl:Class ; rdfs:comment "Hemoglobin D-Punjab Trait causes no clinical or hematological alterations" ; rdfs:label "Hemoglobin D-Punjab Trait" ; rdfs:subClassOf obo:SCDO_0000525, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000109 ] . obo:SCDO_1000060 obo:IAO_0000115 "The underlying molecular makeup resulting in sickle cell disease." ; obo:SCDO_0000303 """Probably too specific to warrant inclusion into anther ontology. Consider inclusion of other sub-classes of this term in the Human Phenotype Ontology. -- - Elevated hemoglobin A1c -- - Imbalanced Hemoglobin Synthesis (and the 2 terms below this) -- Methemoglobina -- Others from MESH?: -- J, M, Methemoglobin?""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; a owl:Class ; rdfs:label "SCD Molecular Phenotype" ; rdfs:subClassOf obo:SCDO_0007623, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ] . obo:SCDO_1000061 obo:IAO_0000115 "An altered level of normal hemoglobin (Hemoglobin A (Hb A), Hemoglobin A2 (Hb A2) or Hemoglobin F (Hb F, fetal hemoglobin) in the blood, which may be seen in those suffering with Sickle Cell Disease (SCD)." ; obo:SCDO_0000303 "Probably too specific to SCD be included in other ontologies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Altered Level of Normal Hemoglobin in SCD" ; rdfs:subClassOf obo:SCDO_1000276, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ] . obo:SCDO_1000062 obo:IAO_0000115 "A rare type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin C-Harlem. This condition is described to have a clinical course similar to sickle cell anemia." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Moo-Penn, W., Bechtel, K., Jue, D., Chan, M.S., Hopkins, G., Schneider, N.J., Wright, J. and Schmidt, R.M., 1975. The presence of hemoglobin S and C Harlem in an individual in the United States. Blood, 46(3), pp.363-367." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "SC(Harlem) Disease", "Sickle Cell-Hemoglobin C-Harlem Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S/C-Harlem" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000163, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000006 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000044 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000058 ] . obo:SCDO_1000063 obo:IAO_0000115 "A 106-kb deletion of the beta globin gene cluster." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "HPFH1" ; a owl:Class ; rdfs:label "HBB, 106-KB DEL" ; rdfs:subClassOf obo:SCDO_0004905, obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:NCIT_C129072 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000010 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_1000707 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000069 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000235 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:HP_0011904 ] . obo:SCDO_1000064 obo:IAO_0000115 "A consent model in which participants are given a set of options allowing them to select how they want to participate in the research." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_0000340 "https://www.genome.gov/27559022/informed-consent-glossary/" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Tiered Consent" ; rdfs:subClassOf obo:NCIT_C25460 . obo:SCDO_1000065 obo:IAO_0000115 "Requires that consent to the use of human samples be specific to the 'purpose' for which the sample is to be used and that where previously collected samples are to be used for a different 'research purpose' further consent should generally be obtained." ; obo:SCDO_0000303 "Request inclusion into the ICO below \"Informed Consent\"." ; obo:SCDO_0000340 "https://www.alrc.gov.au/publications/15-human-genetic-research-and-consent/specific-consent" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Specific Consent" ; rdfs:subClassOf obo:SCDO_0007087 . obo:SCDO_1000066 obo:IAO_0000115 "The determination of the amount of hemoglobin F present in a sample." ; obo:SCDO_0000303 """Suggest update to label in NCIT (from \"Hemoglobin F Measurement\") Add sub-classes of \"Fetal hemoglobin determination\" in SNOMED CT?""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C92262" ; oboInOwl:hasExactSynonym "Fetal Hemoglobin Test", "HGBF Test" ; a owl:Class ; rdfs:label "Hemoglobin F Test" ; rdfs:subClassOf obo:SCDO_0000522 . obo:SCDO_1000067 obo:IAO_0000115 "When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a null mutation, called beta-zero, because of the resulting inability to synthesize any beta-globin chain." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "S/Beta-Zero-Thal Genotype", "S/Beta-Zero-Thalassaemia Genotype", "S/Beta-Zero-Thalassemia" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/Beta Zero Thalassaemia" ; rdfs:subClassOf obo:SCDO_1000107, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_0002475 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000241 ] . obo:SCDO_1000068 obo:IAO_0000115 "'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a severe beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000078 ; obo:SCDO_0000340 "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." ; oboInOwl:hasExactSynonym "Severe S/Beta-Plus-Thal", "Severe S/Beta-Plus-Thal Genotype", "Severe S/Beta-Plus-Thalassaemia Genotype" ; a owl:Class ; rdfs:label "deprecated Severe S/Beta-Plus-Thal" ; rdfs:subClassOf obo:SCDO_1000091 ; owl:deprecated true . obo:SCDO_1000069 obo:IAO_0000115 "Genotype whereby a person is heterozygous for a hemoglobin S mutation and heterozygous for a mutation that causes persistant fetal hemoglobin production into adulthood. HPFH causative mutations are largely due to deletions in the beta-globin locus, but also by point mutations in the gamma-globin gene promoters." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Stamatoyannopoulos, G. (2005). Control of globin gene expression during development and erythroid differentiation. Experimental Hematology, 33(3), 259. http://doi.org/10.1016/j.exphem.2004.11.007" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype S/HPFH", "S/HPFH Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/HPFH" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_1000010 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_0006860 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:HP_0011904 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ] . obo:SCDO_1000070 obo:IAO_0000115 "A compound heterozygous genotype, involving the mutations for Hemoglobin S (beta6Glu>Val) and Hemoglobin Lepore Boston." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "PMID: 7055103", "Stevens MC, Lehmann H, Mason KP, Serjeant BE, Serjeant GR. 1982. Sickle cell Hb Lepore Boston syndrome. Uncommon differential diagnosis to homozygous sickle cell disease. Am J Dis Child. 136(1):19-22." ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype S/Lepore", "S/Lepore", "S/Lepore Boston Genotype", "S/Lepore Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/Lepore Boston" ; rdfs:subClassOf obo:SCDO_1000107, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0001063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000089 ] . obo:SCDO_1000071 obo:IAO_0000115 "A genotype that involves a double mutation in one beta-globin gene that results in hemoglobin with low oxygen affinity, which results in the polymerisation of the hemoglobin variant (hemoglobin Jamaica Plain) and thus sickling of erythorcytes." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "A/Jamaica Plain Genotype", "A/Jamaica Plain Haemoglobin Genotype", "A/Jamaica Plain Hemoglobin Genotype", "Haemoglobin Genotype A/Jamaica Plain" ; a owl:Class ; rdfs:label "Hemoglobin Genotype A/Jamaica Plain" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_1000164 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000047 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000072 ] . obo:SCDO_1000072 obo:IAO_0000115 "A sickling hemoglobin with reduced oxygen affinity that causes severe hemolytic anemia and sickling of erythrocytes." ; obo:SCDO_0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." ; obo:SCDO_0000340 "http://www.nejm.org/doi/full/10.1056/NEJMoa040771#t=article" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hb JP", "Hb Jamaica Plain", "Hemoglobin JP" ; a owl:Class ; rdfs:label "Hemoglobin Jamaica Plain" ; rdfs:subClassOf obo:SCDO_1000082, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000047 ] . obo:SCDO_1000073 obo:IAO_0000115 "A form of hemoglobin caused by two mutations in its beta-chains, the classic beta S mutation (beta 6 Glu>Val) and beta 23 Val>Ile. Hemoglobin S-Antilles has the same electrophoretic mobility as Hemoglobin S but a distinct isoelectric focus and produces sickling in the carriers of the Hb A/S Antilles trait." ; obo:SCDO_0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hemoglobin S-Antilles" ; rdfs:subClassOf obo:SCDO_1000082, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000045 ] . obo:SCDO_1000074 obo:IAO_0000115 "A form of hemoglobin caused by two mutations in a beta-globin chain, the classic beta S mutation (beta6 Glu> Val) and a beta121 Glu > Lys mutation identical to that of Hb-O Arab. The hemoglobin variant has reduced solubility and there is an apparent increase in red cell sickling tendency. It is reported to cause a rare dominant form of sickle cell disease, Sickle Cell Disease A/S-Oman." ; obo:SCDO_0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." ; obo:SCDO_0000340 , "Nagel, R.L., Daar, S., Romero, J.R., Suzuka, S.M., Gravell, D., Bouhassira, E., Schwartz, R.S., Fabry, M.E. and Krishnamoorthy, R., 1998. HbS-Oman heterozygote: a new dominant sickle syndrome. Blood, 92(11), pp.4375-4382." ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hb S-Oman", "Hemoglobin S (Oman)" ; a owl:Class ; rdfs:label "Hemoglobin S-Oman" ; rdfs:subClassOf obo:SCDO_1000082, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000040 ] . obo:SCDO_1000075 obo:IAO_0000115 "Dominant heterozygosity for the double HBB Glu6Val and Glu121Lys mutation." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "PMID: 9834244" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "A/S-Oman Genotype", "A/S-Oman Haemoglobin Genotype", "A/S-Oman Hemoglobin Genotype", "Haemoglobin Genotype A/S-Oman" ; a owl:Class ; rdfs:label "Hemoglobin Genotype A/S-Oman" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_1000165 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000040 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000074 ] . obo:SCDO_1000076 obo:IAO_0000115 "A form of sickle cell thalassemia, with a mild clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Mild Sickle Cell Disease-S Beta Minus Thalassaemia", "Mild Sickle Cell-Beta Minus Thalassaemia", "Mild Sickle Cell-Beta Minus Thalassemia" ; a owl:Class ; rdfs:label "Mild Sickle Cell Disease-S Beta Minus Thalassemia" ; rdfs:subClassOf obo:SCDO_0001056, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001765 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ] . obo:SCDO_1000077 obo:IAO_0000115 "A form of sickle cell thalassemia, with a moderate clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Moderate Sickle Cell Disease-S Beta Minus Thalassaemia", "Moderate Sickle Cell-Beta Minus Thalassaemia", "Moderate Sickle Cell-Beta Minus Thalassemia" ; a owl:Class ; rdfs:label "Moderate Sickle Cell Disease-S Beta Minus Thalassemia" ; rdfs:subClassOf obo:SCDO_0001056, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001765 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ] . obo:SCDO_1000078 obo:IAO_0000115 "A form of sickle cell thalassemia, with a severe clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Severe Sickle Cell Disease-S Beta Minus Thalassaemia", "Severe Sickle Cell-Beta Minus Thalassaemia", "Severe Sickle Cell-Beta Minus Thalassemia" ; a owl:Class ; rdfs:label "Severe Sickle Cell Disease-S Beta Minus Thalassemia" ; rdfs:subClassOf obo:SCDO_0001056, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0001765 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ] . obo:SCDO_1000079 obo:IAO_0000115 "'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a moderate beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000077 ; obo:SCDO_0000340 "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." ; oboInOwl:hasExactSynonym "Moderate S/Beta-Plus-Thalassaemia" ; a owl:Class ; rdfs:label "deprecated Moderate S/Beta-Plus-Thal" ; rdfs:subClassOf obo:SCDO_1000091 ; owl:deprecated true . obo:SCDO_1000080 obo:IAO_0000115 "'Not described [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_1000076 ; oboInOwl:hasExactSynonym "Mild S/Beta-Plus-Thalassaemia" ; a owl:Class ; rdfs:label "deprecated Mild S/Beta-Plus-Thal" ; rdfs:subClassOf obo:SCDO_1000091 ; owl:deprecated true . obo:SCDO_1000081 obo:IAO_0000115 "Compound heterozygosity for the hemoglobin C (HBB Glu6Lys) mutation and the double HBB Glu6Val, Val23Ile mutation of hemoglobin S-Antilles." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "DOI: 10.1016/S0140-6736(10)61029-X", "PMID: 21131035" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "C/S Antilles Genotype", "C/S Antilles Haemoglobin Genotype", "C/S Antilles Hemoglobin Genotype", "Haemoglobin Genotype C/S Antilles", "beta6Glu>Lys/beta6Glu>Val, beta23Val>Ile" ; a owl:Class ; rdfs:label "Hemoglobin Genotype C/S Antilles" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_1000166 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000045 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000513 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000073 ] . obo:SCDO_1000082 obo:IAO_0000115 "A hemoglobin that sickles due to the presence of two beta-globin gene mutations within the same HBB gene." ; obo:SCDO_0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"." ; obo:SCDO_1000288 "None" ; dc:source , , ; oboInOwl:hasExactSynonym "Doubly Substituted Sickling Hemoglobin" ; a owl:Class ; rdfs:label "Sickling Hemoglobin with Two Beta-Globin Gene Substitutions" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_0003807 . obo:SCDO_1000083 obo:IAO_0000115 "An abnormal hemoglobin in which two mutations occurring in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the lysine in position 132 is replaced by asparagine." ; obo:SCDO_0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." ; obo:SCDO_0000340 "Luo, H.Y., Adewoye, A.H., Eung, S.H., Skelton, T.P., Quillen, K., McMahon, L., Steinberg, M.H. and Chui, D.H., 2004. A novel sickle hemoglobin: Hemoglobin S-South End. Journal of pediatric hematology/oncology, 26(11), pp.773-776." ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hemoglobin S-South End" ; rdfs:subClassOf obo:SCDO_1000082, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000087 ] . obo:SCDO_1000084 obo:IAO_0000115 "A compound heterozygous genotype, involving the mutations for Hemoglobin S and Hemoglobin Quebec Chori, which shows an electrophoretic pattern similar to that of the Hb A/S Genotype, but shows sickling." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Pediatr Blood Cancer. 2007 Aug;49(2):207-10." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype S/Quebec-Chori", "S/Quebec-Chori Genotype", "beta6Glu>Val/beta87Thr>Ile" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/Quebec-Chori" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_1000086 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000046 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000085 ] . obo:SCDO_1000085 obo:IAO_0000115 "An abnormal hemoglobin in which a threonine is replaced by an isoleucine residue at the eighty-seventh position of beta chains. It migrates like HbA but promotes sickling." ; obo:SCDO_0000303 """Suggest update to description in MESH (the term in MESH doesn't currently have a description). Also request inclusion in the HPO, below \"Abnormal Hemoglobin\", for the sake of completion.""" ; obo:SCDO_0000340 , "Witkowska, H.E., Lubin, B.H., Beuzard, Y., Baruchel, S., Esseltine, D.W., Vichinsky, E.P. et al. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. N Engl J Med. 1991; 325: 1150–1154" ; obo:SCDO_1000288 "Suggest update to description" ; dc:source , "http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3" ; oboInOwl:hasDbXref "MESH:C070823" ; oboInOwl:hasExactSynonym "Hb Quebec-Chori" ; a owl:Class ; rdfs:label "Hemoglobin Quebec Chori" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_0003807, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000046 ] . obo:SCDO_1000086 obo:IAO_0000115 "A severe compound heterozygous sickling disorder characterized by the presence of both hemoglobin S and hemoglobin Quebec Chori." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Sickle Cell-Hemoglobin Quebec Chori Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S/Quebec Chori" ; rdfs:subClassOf obo:SCDO_1000163, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:CHMO_0001009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000084 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000046 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000085 ] . obo:SCDO_1000087 obo:IAO_0000115 "A mutation where the lysine residue in position 132 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation on its own produces Hb Yamagata which has reduced oxygen affinity, but no distinctive clinical abnormalities. However, when present in the same gene as the Hb S mutation (HBB, GLU6VAL), the sickling HbS-South End is produced." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Contributing Beta S-South End Mutation", "Contributing Hb S-South End Mutation", "Hb Yamagata Mutation", "LYS132ASN" ; a owl:Class ; rdfs:label "HBB, LYS132ASN" ; rdfs:subClassOf obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000090 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000083 ] . obo:SCDO_1000088 obo:IAO_0000115 "A compound heterozygous genotype, involving the mutations for hemoglobin S and hemoglobin S-South End." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype S/S-South End", "S/S-South End Genotype", "beta Glu6Val, GAG>GTG/beta Glu6Val, GAG>GTG; beta Lys132Asn, AAA>AAC", "beta6Glu>Val/beta132Lys>Asn" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/S-South End" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_1000090 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000087 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000083 ] . obo:SCDO_1000089 obo:IAO_0000115 "The most common Hemoglobin Lepore type and the only type of the three known variants described in association with HbS. This abnormal hemoglobin consists of two normal alpha globin chains (HBA) and two deltabeta globin fusion chains which occur due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis." ; obo:SCDO_0000303 """Suggest inclusion in the HPO, below \"Abnormal Hemoglobin\". Hb Lepore is produced at a reduced rate and this is why the disease is related to the Β-thalassemic syndromes. Quantity in heterozygotes 7-13%; found in combination with Hb S, Hb C, beta+-thal, and in the homozygous state. The most common Hb Lepore type; found mainly in Italian families; it has also been observed in families from Rumania, Yugoslavia, Turkey, Cyprus, Jamaica, Cuba, Greece, England, Australia, Mexico, etc""" ; obo:SCDO_0000340 "http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome#Homozygous_Hb_Lepore", "http://globin.cse.psu.edu/html/huisman/variants/hybrid/Lepore-Boston-Washington.html" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Hb Lepore Boston-Washington", "Hb Lepore-B-W", "Hb Lepore-Boston-Washington", "Hb Lepore-WB", "Hb Lepore-Washington-Boston", "Hemoglobin Lepore Boston-Washington", "Hemoglobin Lepore-Boston-Washington" ; a owl:Class ; rdfs:label "Hemoglobin Lepore Boston" ; rdfs:subClassOf obo:SCDO_0000007, obo:SCDO_0003807 . obo:SCDO_1000090 obo:IAO_0000115 "A rare, reported severe, type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin S-South End." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Luo, H.Y., Adewoye, A.H., Eung, S.H., Skelton, T.P., Quillen, K., McMahon, L., Steinberg, M.H. and Chui, D.H., 2004. A novel sickle hemoglobin: Hemoglobin S-South End. Journal of pediatric hematology/oncology, 26(11), pp.773-776." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "Sickle Cell-Hemoglobin S-South End Disease" ; a owl:Class ; rdfs:label "Sickle Cell Disease-S/S-South End" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000163, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000088 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000087 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:EUPATH_0000215 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000083 ] . obo:SCDO_1000091 obo:IAO_0000115 "'Sb+ thalassemia is an inherited condition. Hemoglobin S comes from one parent and Beta plus thalassemia comes from the other parent. Instead of appearing round (like donuts), red blood cells are somewhat small, pale and misshapen. [Curator team: []]'" ; obo:IAO_0100001 obo:SCDO_0001056 ; a owl:Class ; rdfs:label "deprecated Sickle beta plus thalassemia" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000092 obo:IAO_0000115 "A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis." ; obo:IAO_0100001 obo:SCDO_0001288 ; obo:SCDO_0000303 "Ask a clinician if this is different to a cluster headache?" ; obo:SCDO_0000340 "https://meshb.nlm.nih.gov/record/ui?ui=D003027" ; oboInOwl:hasDbXref "MESH:D003027" ; a owl:Class ; rdfs:label "deprecated-Acute Severe Headache" ; rdfs:subClassOf obo:SCDO_0001336 ; owl:deprecated true . obo:SCDO_1000093 obo:IAO_0000115 "A medically undesirable event occurring in a research subject, such as an abnormal sign, symptom, worsening of a disease, injury, etc. A serious adverse event (SAE) results in death, hospitalization (or increased hospital stay), persistent disability, birth defect, or any other outcome that seriously jeopardizes the subject's health." ; obo:SCDO_0000340 obo:OAE_0000001 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000093" ; oboInOwl:hasDbXref "OAE:0000001" ; oboInOwl:hasExactSynonym "Adverse Reaction" ; a owl:Class ; rdfs:label "Adverse Event (AE)" ; rdfs:subClassOf obo:SCDO_0000391 . obo:SCDO_1000094 obo:IAO_0000115 "A desirable research outcome or state of affairs, such as medical treatment, clinically useful information, or self-esteem. In the oversight of human subjects research, money is usually not treated as a benefit." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 "Shamoo AE and Resnik DB, Responsible Conduct of Research, 3rd ed. (New York: Oxford University Press, 2015)." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Research Benefit" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_1000095 obo:IAO_0000115 "A situation in which an individual or their close associates might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust.The concept refers both to actual conflict of interest and the appearance or perception of conflict." ; obo:SCDO_0000340 "http://purl.bioontology.org/ontology/MESH/D016265" ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasDbXref "MESH:D016265" ; oboInOwl:hasExactSynonym "Interest Conflict" ; a owl:Class ; rdfs:label "Conflict of Interest" ; rdfs:subClassOf obo:SCDO_0300005, obo:SCDO_1000430 . obo:SCDO_1000097 obo:IAO_0000115 "An homo sapiens that bears an experimental subject role which is realized through his/her participation in a scientific technique as the subject of interest (ie as the subject about which data is generated in an assay or study, or the entity that is transformed or modified in a material processing technique)." ; obo:SCDO_0000340 obo:ERO_0001964 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000097" ; oboInOwl:hasDbXref "ERO:0001964" ; a owl:Class ; rdfs:label "Human Subject" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_1000098 obo:IAO_0000115 "A paper or electronic questionnaire specifically used in research by the sponsor of the research to collect data from each research participant. All data on each participant in the study are held and/or documented in the CRF, including adverse events." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps as parent of \"electronic case report form\" in the Ontology for Biomedical Investigations (OBI)" ; obo:SCDO_0000340 "Debbie Kennedy, CRF Designer, Canary Publications, ISBN 0-9531174-7-2" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Case Report Form (CRF)" ; rdfs:subClassOf obo:SCDO_0300003 . obo:SCDO_1000099 obo:IAO_0000115 "Genes with alleles that affect the phenotype associated with a nonallelic gene." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000099" ; oboInOwl:hasDbXref "MESH:D060045" ; oboInOwl:hasExactSynonym "Gene, Modifier" ; a owl:Class ; rdfs:label "Modifier Gene" ; rdfs:subClassOf obo:SCDO_0000444 . obo:SCDO_1000100 obo:IAO_0000115 "The type of ICD-10-CM code, in terms of a code's usability for reimbursement purposes." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "ICD-10-CM Code Type" ; rdfs:subClassOf obo:SCDO_0000245 . obo:SCDO_1000101 a owl:AnnotationProperty ; rdfs:label "curation status - complete" . obo:SCDO_1000102 a owl:AnnotationProperty ; rdfs:label "curation status - incomplete" . obo:SCDO_1000103 obo:IAO_0000115 "A specific region that is mapped within a genome. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or hereditary disease." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000103" ; oboInOwl:hasDbXref "MESH:D056426" ; oboInOwl:hasExactSynonym "Genetic Loci", "Loci, Genetic", "Locus, Genetic" ; a owl:Class ; rdfs:label "Genetic Locus" ; rdfs:subClassOf obo:SCDO_0005722 . obo:SCDO_1000104 obo:IAO_0000115 "The protein subunits that comprise multimeric hemoglobins." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000104" ; oboInOwl:hasDbXref "MESH:D055554" ; a owl:Class ; rdfs:label "Hemoglobin Subunits" ; rdfs:subClassOf obo:NCIT_C26548 . obo:SCDO_1000105 obo:IAO_0000115 "Members of the alpha-globin family. In humans, they are encoded in a gene cluster on chromosome 16. They include hemoglobin subunit zeta and hemoglobin subunit alpha. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult hemoglobin is comprised of 2 alpha-globin chains and 2 beta-globin chains." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000105" ; oboInOwl:hasDbXref "MESH:D055542" ; oboInOwl:hasExactSynonym "Alpha-Globins" ; a owl:Class ; rdfs:label "Alpha-Globin Family Members" ; rdfs:subClassOf obo:SCDO_0005339, obo:SCDO_1000104 . obo:SCDO_1000106 obo:IAO_0000115 """Sickle cell disease (SCD) is a pleiotropic inherited disorder of the blood, characterised by the appearance of sickle-shaped red blood cells and anemia. It results from homozygosity for the sickle beta-globin gene mutation at position 6 (glu > val), or compound heterozygosity for the sickle gene and either another mutation for a different hemoglobin variant or one of numerous beta-thalassemia mutations.""" ; obo:SCDO_0000303 """Suggest update to description in NCIT. Sickle cell diseases include inheritance of the gene for sickle hemoglobin from one parent and one of the following: A gene for sickle hemoglobin from the other parent (Hb SS), A gene for another abnormal hemoglobin from the other parent (Hb SC, HbSD Punjab, HbSO Arab, HbS Leopore, or Hb SE), A gene that limits hemoglobin production from the other parent (sickle beta +/0 thalassemia). In S beta (+) thalassemia there is some production of beta globin, and in S beta (0) thalassemia there is no production of beta globin.""" ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source ; oboInOwl:hasExactSynonym "Banana Cell Disease", "Drepanocytosis", "SCD", "Sickle Cell Disorder", "Sickle Cell Hemoglobinopathy", "Sickle Hemoglobinopathy", "Sickle-Cell Disorder" ; a owl:Class ; rdfs:label "Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_0000552, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000469 ; owl:someValuesFrom obo:SCDO_0000311 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_0009786 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ] . obo:SCDO_1000107 obo:IAO_0000115 "The combination of the hemoglobin S mutation (beta6Glu>Val) and a beta-thalassemia mutation." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Hemoglobin Genotype S/Beta Thalassaemia", "S/Beta -Thal Genotype", "S/Beta -Thalassaemia Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/Beta Thalassemia" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_0007624 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000240 ] . obo:SCDO_1000108 obo:IAO_0000115 "A mutation where the serine in position 9 in the primary sequence of a beta-chain produced by the HBB gene is replaced by tyrosine. This mutation is one of 2 amino acid substitutions in the same beta chain that produces the asymptomatic Hemoglobin D-Agri, the other mutation being HBB, GLU121GLN, which on its own produces Hemoglobin D-Punjab." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Beta D-Agri Mutation" ; a owl:Class ; rdfs:label "HBB, SER9TYR" ; rdfs:subClassOf obo:SCDO_0002305, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000109 obo:IAO_0000115 "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source , ; oboInOwl:hasExactSynonym "Beta 121Glu>Gln", "Beta D-Punjab Mutation" ; a owl:Class ; rdfs:comment "Derived from a point mutation in the beta-globin gene (HBB: c.364G>C; rs33946267)." ; rdfs:label "HBB, GLU121GLN" ; rdfs:subClassOf obo:SCDO_0002305, obo:SCDO_0009786, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001061 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_1000059 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_0000528 ] . obo:SCDO_1000110 obo:IAO_0000115 "A mutation where the glycine in position 16 in the primary sequence of a beta-chain produced by the HBB gene is replaced by arginine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Beta D-Bushman Mutation" ; a owl:Class ; rdfs:label "HBB, GLY16ARG" ; rdfs:subClassOf obo:SCDO_0002305, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000111 obo:IAO_0000115 "A mutation where the asparargine acid in position 19 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Beta D-Ouled Rabah Mutation" ; a owl:Class ; rdfs:label "HBB, ASN19LYS" ; rdfs:subClassOf obo:SCDO_0002305, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000112 obo:IAO_0000115 "A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Beta D-Iran Mutation" ; a owl:Class ; rdfs:label "HBB, GLU22GLN" ; rdfs:subClassOf obo:SCDO_0002305, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000113 obo:IAO_0000115 "A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Beta D-Granada Mutation" ; a owl:Class ; rdfs:label "HBB, GLU22VAL" ; rdfs:subClassOf obo:SCDO_0002305, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000114 obo:IAO_0000115 "A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Beta D-Ibadan Mutation" ; a owl:Class ; rdfs:label "HBB, THR87LYS" ; rdfs:subClassOf obo:SCDO_0002305, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000115 obo:IAO_0000115 "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by alanine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Beta D-Neath Mutation" ; a owl:Class ; rdfs:label "HBB, GLU121ALA" ; rdfs:subClassOf obo:SCDO_0002305, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000054 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000226 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000230 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000116 obo:IAO_0000115 "The Adja ethnic group are mostly farmers and live in the southern part of Benin Republic. They make up 15% of the general country population. This group of people migrated into Benin between the 12th and 13th centuries from River Mono. The primary language is Aja-Gbe with a majority of the people being trilingual." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negigable" ; dc:source "Demographic and Health Surveys Program (2011-2012)" ; oboInOwl:hasExactSynonym "Adja Ethnic Group" ; a owl:Class ; rdfs:label "Adja" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000117 obo:IAO_0000115 "Bariba is the ethnic group dominating the northern side of Benin, who constitute 9% of the population. They are the first inhabitants of Benin and are concentrated in the capital city, Nikki. One of their leading practices is horse riding, which is a practice that has been enjoyed from generation to generation. With agriculture being their dominant occupation, Bariba people have a diverse range of produce such as corn, rice and palm oil." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:source "Demographic and Health Surveys Program (2011-2012)" ; oboInOwl:hasExactSynonym "Bariba Ethnic Group" ; a owl:Class ; rdfs:label "Bariba" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000118 obo:SCDO_1000288 "Negligable" ; oboInOwl:hasExactSynonym "Dendi Ethnic Group" ; a owl:Class ; rdfs:label "Dendi" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000119 obo:IAO_0000115 "The largest ethnic group in Benin is Fon/Dahomey which constitutes 39% of the total population. Established in 1600 by the Fon, a group that came about through the intermarriage between the Adja and local Gedevi." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic and Health Surveys Program (2011-2012)" ; oboInOwl:hasExactSynonym "Fon Ethnic Group" ; a owl:Class ; rdfs:label "Fon" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000120 obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Yoa Ethnic Group" ; a owl:Class ; rdfs:label "Yoa" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000121 obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Betamaribe Ethnic Group" ; a owl:Class ; rdfs:label "Betamaribe" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000122 obo:IAO_0000115 "The Embu are a Bantu-speaking people who are closely related to the Gikuyu of Ndia and Gicugu to the west, the Mbeere and the Kamba to the southeast, and the Chuka and the Meru to the north in Kenya." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Embu Ethnic Group" ; a owl:Class ; rdfs:label "Embu" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000123 obo:IAO_0000115 "The Kalenjin ethnic group are one of the five largest ethnic groups in Kenya. They are a Nilotic ethnic group and they are mainly farmers." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Kalenjin Ethnic Group" ; a owl:Class ; rdfs:label "Kalenjin" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000124 obo:IAO_0000115 "The Kamba ethnic group, also known as Akamba is one of the five largest ethnic groups in Kenya. They are Bantu-speaking people and primarily agriculturists." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Kamba Ethnic Group" ; a owl:Class ; rdfs:label "Kamba" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000125 obo:IAO_0000115 "The Kikuyu are the largest single ethnic tribe in Kenya, making up 22% of the country's population. It is believed that the Kikuyu people migrated from Lake Chad to East Africa in 1000 AD, settling in the fertile central highlands of Kenya and engaging in farming." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Kikuyu Ethnic Group" ; a owl:Class ; rdfs:label "Kikuyu" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000126 obo:IAO_0000115 "The Kisii tribe (also known as the Gusii tribe) is a Bantu ethnic group who occupy the Kisii highlands in Nyanza, Western Kenya. The Kisiis constitute the sixth largest ethnic group, comprising about seven percent of the national population. Kisii, which is their ethnic language, is also traditionally known as Ekegusii." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Gusii", "Kisii Ethnic Group" ; a owl:Class ; rdfs:label "Kisii" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000127 obo:IAO_0000115 "The Luhya ethnic group, also known as the Abaluhya, Baluhya, or Abaluyia, is a Bantu tribe living in Kenya's agriculturally fertile western region. They are the second largest tribe in Kenya and neighbors to some of the Nilotic tribes, including the Luo, Kalenjin, Maasai and Teso (Iteso)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Luhya Ethnic Group" ; a owl:Class ; rdfs:label "Luhya" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000128 obo:IAO_0000115 "Luo, also called Joluo or Kavirondo constitute the fourth largest ethnic group in Kenya. The Luo speak a Nilotic language of the Nilo-Saharan language family." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Luo Ethnic Group" ; a owl:Class ; rdfs:label "Luo" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000129 obo:IAO_0000115 "A smaller ethnic group, accounting for only about 0.7 percent of Kenya's population, with a similar number living in Tanzania. Maasais speak Maa, a Nilotic ethnic language from their origin in the Nile region of North Africa." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Maasai Ethnic Group" ; a owl:Class ; rdfs:label "Maasai" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000130 obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "Peulh Ethnic Group" ; a owl:Class ; rdfs:label "Peulh" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000131 obo:IAO_0000115 "Yoruba is an ethnic group coming from Nigeria and well settled along the eastern boundary of Benin. They are more than 18% of the population. The majority of the Yoruba people in Benin are descendants of the Ife tribe, and the Yoruba people are predominantly of the Muslim religion." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source "Demographic and Health Surveys Program (2011-2012)" ; oboInOwl:hasExactSynonym "Yoruba Ethnic Group" ; a owl:Class ; rdfs:label "Yoruba" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000132 obo:IAO_0000115 "The Meru tribe or Merus is a Bantu ethnic group. They reside on Mount Kenya's agriculturally rich northeastern slopes, in Kenya's Eastern Province. The name Meru refers to both the people and the location. Merus are primarily agrarian, raising a few domestic animals." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Meru Ethnic Group" ; a owl:Class ; rdfs:label "Meru" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000133 obo:IAO_0000115 "The Mijikenda tribe is a Kenyan coastal Bantu tribe that consists of nine closely related sub-tribes. \"Mijikenda\" literally means nine homes or nine homesteads (in Swahili), referring to the common ancestry of the Mijikenda people. The nine Mijikenda sub-tribes are believed to be nine different homes of the same tribe. Each sub-tribe speaks its own dialect of the Mijikenda language." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Mijikenda", "Mijikenda Ethnic Group" ; a owl:Class ; rdfs:label "Mijikenda/Swahili" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000134 obo:IAO_0000115 "A Cushitic speaking people comprising a small minority of Kenya's population. The Somali tend large herds of cattle, goats, sheep, and camels in the dry, arid lands of Northern Kenya. They are politically well organized and are united by both family allegiances and political treaties. The Somali also produce exquisitely carved headrests and woven artifacts." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Somali Ethnic Group" ; a owl:Class ; rdfs:label "Somali" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000135 obo:IAO_0000115 "The Taita people are a Bantu tribe living in the Taita Hills on Kenya's southwest, near the Tanzania border and surrounding plains. Taita tribe actually consists of three separate but closely-related tribes: Wadawida (or Taita), Wasaghala (Sagalla) and Wataveta (Taveta)." ; obo:SCDO_0000303 """Perhaps change label to \"Taveta\"? Include the Wadawida (or Taita), Wasaghala (Sagalla) and Wataveta (Taveta) as sub-classes? Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:source "Demographic Health and Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Taita/Taveta Ethnic Group", "Taveta Ethnic Group" ; a owl:Class ; rdfs:label "Taita/Taveta" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000136 obo:IAO_0000115 "The Borana are a branch of the populous Oromo people found in southern Ethiopia and northern Kenya." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Borana Ethnic Group" ; a owl:Class ; rdfs:label "Borana" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000137 obo:IAO_0000115 "It is the second largest sub-tribe of the Luhya ethnic group in Kenya." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Maragoli Ethnic Group" ; a owl:Class ; rdfs:label "Maragoli" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000138 obo:IAO_0000115 "The Pokot are a Kalenjin-speaking people whose language incorporates words from the neighboring Karamojong and Turkana. The Pokot live in an ecologically complex region that extends from the plains of eastern Uganda across the highlands of northwestern Kenya to the plains of Lake Baringo." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic Health and Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Pokot Ethnic Group" ; a owl:Class ; rdfs:label "Pokot" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000139 obo:IAO_0000115 "The Turkana tribe is a nomadic pastoralist people that inhabit the Turkana district in Kenya's Rift Valley Province. Turkana tribe is part of the Nilotic tribes and constitutes the second largest pastoralist community in Kenya after the Maasais. They speak the Turkana language, which is Nilotic and similar to the Maasai language." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:source "Demographic and Health Surveys Program (2015)" ; oboInOwl:hasExactSynonym "Turkana Ethnic Group" ; a owl:Class ; rdfs:label "Turkana" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000141 obo:IAO_0000115 "Bassa is a Niger-Congo Kru language. Historians have traced the Bassa's origins back to Egypt nearly six thousand years ago. Due to their migration from Egypt to other parts of Africa, the Bassa in Liberia share a similar history with Bassa groups in other parts of the continent such as Nigeria (Bassa Nge), The Democratic Republic of the Congo (Bassaa la Mpasu), Togo (Basa'r), Senegal (Bassa-Ri), and Cameroon (Basaa Mpoo)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Negligable" ; dc:source "Demographic and Health Surveys Program (2013)" ; oboInOwl:hasExactSynonym "Bassa Ethnic Group" ; a owl:Class ; rdfs:label "Bassa" ; rdfs:subClassOf obo:NCIT_C16564 . obo:SCDO_1000142 obo:IAO_0000115 "Spectrophotometry involves the use of a spectrophotometer to measure the amount of light that a sample absorbs. The instrument operates by passing a beam of light through a sample and measuring the intensity of light reaching a detector." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000142" ; oboInOwl:hasDbXref "BAO:0000049" ; oboInOwl:hasExactSynonym "Spectrophotometry Method" ; a owl:Class ; rdfs:label "Spectrophotometry" ; rdfs:subClassOf obo:SCDO_0000896 . obo:SCDO_1000143 obo:IAO_0000115 "A recommendation on the appropriate treatment and care of people with a specific disease or condition, based on the best available evidence, designed to help healthcare professionals in their work." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000143" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "FaBiO:d4e2515" ; oboInOwl:hasExactSynonym "Clinical Guideline" ; a owl:Class ; rdfs:label "Disease Management Guideline" ; rdfs:subClassOf obo:SCDO_1000160 . obo:SCDO_1000144 obo:IAO_0000115 "Management protocols for the purposes of consistency and standardisation, which could also facilitate sharing of resources between centers for maximal utility. These recommendations have been developed for the South African setting, and it is intended to update them regularly to meet new demands and challenges." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "N A Alli, M Patel, H D Alli, et al. Recommendations for the management of sickle cell disease in South Africa. SAMJ. 2014, Vol. 104, No. 11." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "South African Management Guidelines" ; rdfs:label "Recommendations for the Management of Sickle Cell Disease in South Africa" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000145 obo:IAO_0000115 "Guidelines for the management of specific clinical problems and protocols for various therapeutic procedures for patients with sickle cell disease and thalassaemia; to facilitate uniformity and standardization of care across different disciplines." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "National guideline for the control and management of sickle cell disease. 2014." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "A Nigerian document." ; rdfs:label "National Guideline for the Control and Management of Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000146 obo:IAO_0000115 "Guidelines for health care professionals for management of sickle cell disease in patients in the Tanzanian context." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Management of Sickle Cell Disease - The United Republic of Tanzania" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:comment "Tanzania Management Guidelines" ; rdfs:label "Management of Sickle Cell Disease - The United Republic of Tanzania" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000147 obo:IAO_0000115 "A booklet with information and standard guidelines to help parents learn about sickle cell disease and how to take care of their children with sickle cell disease." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "A parent's guide to managing sickle cell disease. Brent Sickle Cell and Thalassaemia Centre. 3rd Edition 2012." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "A UK document.(for parents)" ; rdfs:label "A Parental Guide to Managing Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000148 obo:IAO_0000115 "A document that includes standards and guidelines for clinical care and recommendations for how care for adults with sickle cell disease should be delivered." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Standards for Clinical Care of Adults with Sickle Cell Disease in the UK, 2nd Edition. 2018, Sickle Cell Society." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "A UK document (for adults with SCD)" ; rdfs:label "Standards for Clinical Care of Adults with Sickle Cell Disease in the UK" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000149 obo:IAO_0000115 "The second edition of the Clinical Care Guidelines of the Sickle Cell Unit, containing revised and expanded guidelines for the management of sickle cell disease. It outlines a standard of care that is informed by best practice, taking into account resource limitations locally and regionally. It also contains patient information leaflets." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit, 2015" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:comment "Jamaican Management Guidelines" ; rdfs:label "Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000150 obo:IAO_0000115 "Standard of care guidelines that promote excellence in sickle cell care, and that lead to improved patient experiences around care and treatment." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Segbefia C, Pendergrast J, Amid A, et al. 2015. Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada. The Canadian Haemoglobinopathy Association." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "A Canadian document." ; rdfs:label "Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000151 obo:IAO_0000115 "A document that include standards and guidelines for clinical care and recommendations for how care for children with sickle cell disease should be delivered." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Sickle cell disease in children, standards and guidelines for clinic care. 2nd edition. October 2010" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "A UK document (for children with SCD)" ; rdfs:label "Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000152 obo:IAO_0000115 "Guidelines providing the best science-based recommendations to guide practice decisions for primary care providers and other clinicians, nurses, and staff who provide emergency or continuity care to individuals with sickle cell disease (SCD). They assist health care professionals in the management of common issues, including routine health maintenance, the recognition and treatment of common acute and chronic complications and comorbidities of SCD, as well as the indications for and monitoring of hydroxyurea and blood transfusion therapy. The guidelines address the care of infants, children, adolescents, and adults with SCD, with the goal of facilitating high-quality and appropriate care for all individuals with this disease." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report, 2014" ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:comment "USA Management Guidelines Children" ; rdfs:label "Evidence-Based Management of Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000153 obo:IAO_0000115 "A review of service delivery across Europe to children with sickle cell disease (SCD), reporting on the available minimum standards of care and future perspectives." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_1000288 "None" ; dc:source "Colombatti R and Sainati L. Management of children with sickle cell disease in Europe: current situation and future perspectives. EMJ Hematol. 2016;4[1]:129-135." ; a owl:Class ; rdfs:comment "European document (Colombatti)" ; rdfs:label "Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000154 obo:IAO_0000115 "A document that describes various ways in which sickle cell disease can be managed and its complications can be prevented in children." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_1000288 "None" ; dc:source "Am J Hematol. 2011 Jan;86(1):72-5. doi: 10.1002/ajh.21865." ; a owl:Class ; rdfs:comment "European document for children with SCD (Montalambert)" ; rdfs:label "ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000155 obo:IAO_0000115 "Research conducted on members of families, examining the affects of genetics, the environment, or twin offspring." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000155" ; oboInOwl:hasDbXref "EDDA:familial_study" ; oboInOwl:hasExactSynonym "Familial Studies", "Familial Study", "Family Based Study", "Family Study" ; a owl:Class ; rdfs:label "Family Study" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SCDO_1000157 obo:IAO_0000115 "The distinguishing qualities or prominent aspects of an individual person that have some relation with quality of life." ; obo:SCDO_0000303 "Probably too specific to SCDO to be included in other ontologies?" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Quality of Life Related Personal Attribute" ; rdfs:subClassOf obo:NCIT_C17047 . obo:SCDO_1000158 obo:IAO_0000115 "Hemoglobin that has undergone conformational changes resulting in increased hydrophobicity that results in the formation of solid crystals consisting of hemoglobin particles." ; obo:SCDO_0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Crystallised Haemoglobin", "Crystallized Haemoglobin", "Crystallized Hemoglobin", "Haemoglobin Crystals", "Hemoglobin Crystals" ; a owl:Class ; rdfs:label "Crystallised Hemoglobin" ; rdfs:subClassOf obo:SCDO_0003807 . obo:SCDO_1000159 obo:IAO_0000115 "When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a mutation that reduces the amount of beta-globin chain synthesised." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hemoglobin Genotype S/Beta Minus Thalassaemia" ; rdfs:subClassOf obo:SCDO_1000107, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0001056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_0001765 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000976 ] . obo:SCDO_1000160 obo:IAO_0000115 "Work consisting of a set of statements, directions, or principles presenting current or future rules or policy. Guidelines may be developed by government agencies at any level, institutions, organizations such as professional societies or governing boards, or by the convening of expert panels. The text may be cursive or in outline form, but it is generally a comprehensive guide to problems and approaches in any discipline or activity. This concept relates to the general conduct and administration of health care activities rather than to specific decisions for a particular clinical condition." ; obo:SCDO_0000303 "Do we rather want to use the more specific MESH term \"Practice Guideline\"?" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000160" ; oboInOwl:hasDbXref "MESH:D016431" ; a owl:Class ; rdfs:label "Guideline" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_1000161 obo:IAO_0000115 "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains of hemoglobin S. Individuals with this genotype are known to be carriers of the sickle cell trait." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype AS", "Sickle Cell Trait Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype AS" ; rdfs:subClassOf obo:SCDO_1000048, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0001055 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000514 ] . obo:SCDO_1000162 obo:IAO_0000115 "The condition in which an individual with sickle cell trait shows symptoms of sickle cell disease such as anemia or acute chest syndrome." ; obo:IAO_0100001 obo:SCDO_1000211 ; obo:SCDO_0000340 ; dc:source ; oboInOwl:hasExactSynonym "Clinical Sickle Cell Disease in the Heterozygous State", "Dominant Sickle Cell Disease" ; a owl:Class ; rdfs:comment """Often these individuals have co-inherited another hemoglobin mutation that decreases hemoglobin solubility (eg, HbS-Antilles; Hb-Quebec-Chori; HbS-Oman; Hb Jamaica Plain). Other rare causes of symptomatic sickle cell trait include: mosaicism for cells in which only the sickle mutation was expressed due to post-zygotic uniparental disomy, and when sickle cell trait coexists with pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling.""" ; rdfs:label "deprecated-Symptomatic Sickle Cell Trait" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000163 obo:IAO_0000115 "A hemoglobinopathy in which the sickle mutation (HBB, Glu6Val) is inherited in combination with another beta-globin gene mutation, other thanHBB, Glu6Val." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Compound Heterozygous Sickling Disorder" ; a owl:Class ; rdfs:label "Compound Heterozygous Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_0001051 . obo:SCDO_1000164 obo:IAO_0000115 "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta68 Leu > Phe mutation.The other beta globin allele produces normal beta globin chains." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Sickle Cell Disease A/Jamaica Plain" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000211, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000006 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000047 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:HP_0001878 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000218 ; owl:someValuesFrom obo:NCIT_C3890 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000072 ] . obo:SCDO_1000165 obo:IAO_0000115 "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation (beta6 Glu > Val) and the hemoglobin O-Arab mutation (beta121 Glu > Lys). The other beta globin allele produces normal beta globin chains." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Sickle Cell Disease A/S-Oman" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000211, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000006 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000075 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000040 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000074 ] . obo:SCDO_1000166 obo:IAO_0000115 "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta 23 Val>Ile mutation. The other beta globin allele produces normal beta globin chains." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Sickle Cell Disease C/S Antilles" ; rdfs:subClassOf obo:SCDO_0008262, obo:SCDO_1000211, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:NCIT_C15709 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0000666 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:SCDO_1000243 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000172 ; owl:someValuesFrom obo:SCDO_1000081 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000045 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_0000513 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000073 ] . obo:SCDO_1000170 obo:IAO_0000115 "A directive information entity that specifies how to establish a diagnosis based on clinical findings." ; obo:SCDO_0000340 obo:AERO_0000001 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000170" ; oboInOwl:hasDbXref "AERO:0000001" ; a owl:Class ; rdfs:label "Diagnosis Guideline" ; rdfs:subClassOf obo:SCDO_1000160 . obo:SCDO_1000171 obo:IAO_0000115 "A relation between a Diagnostic Tool (test, method, assay, etc.) or the Diagnostic Measurement obtained from such a tool and a specific Diagnostic Device, where the Diagnostic Device is used in the application of the Diagnostic Tool or to obtain the Diagnostic Measurement." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has diagnostic device" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000172 obo:IAO_0000115 "A relation between a condition (hemoglobinopathy) and the genotype that causes the condition." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has causal genotype" ; rdfs:subPropertyOf obo:SCDO_0000660 . obo:SCDO_1000173 obo:IAO_0000115 "An ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes as there are no codes with a greater level of specificity under each code." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source , ; oboInOwl:hasExactSynonym "Specific ICD-10-CM Code" ; a owl:Class ; rdfs:label "Billable ICD-10-CM Code" ; rdfs:subClassOf obo:SCDO_1000100 . obo:SCDO_1000174 obo:IAO_0000115 "An ICD-10-CM diagnosis code that is not billable as there are more specific codes below it that contain a greater level of detail." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Non-specific ICD-10-CM Code" ; a owl:Class ; rdfs:label "Non-Billable ICD-10-CM Code" ; rdfs:subClassOf obo:SCDO_1000100 . obo:SCDO_1000175 obo:IAO_0000115 "An object property that specifies the type of an ICD-10-CM code, whether Billable or Non-Billable." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:domain obo:SCDO_0000607 ; rdfs:label "is ICD-10-CM code type" ; rdfs:range obo:SCDO_1000100 ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000176 obo:IAO_0000115 "An indication of whether or not a clinical code requires an additional code to be specified with it. Annotation is either \"yes\", \"no\" or \"if applicable, X\", where X is the name of a diagnosis for which a code should be provided if it is applicable." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_0000607 ; rdfs:label "requires additional code" . obo:SCDO_1000177 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:N48.32" ; oboInOwl:hasExactSynonym "N48.32", "Priapism due to disease classified elsewhere" ; a owl:Class ; rdfs:label "N48.32 Priapism due to disease classified elsewhere" ; rdfs:subClassOf obo:SCDO_0000607, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0000923 ] . obo:SCDO_1000178 obo:IAO_0000115 "A data element in the SickleInAfrica Extended Demographics data capture instrument." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "SickleInAfrica Extended Demographics DE" ; a owl:Class ; rdfs:label "SickleInAfrica Extended Demographics Data Element" ; rdfs:subClassOf obo:SCDO_1000508 . obo:SCDO_1000179 obo:IAO_0000115 "A lack of production of hemoglobin E." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Absent Haemoglobin E", "Haemoglobin E Absent", "Hemoglobin E Absent", "Normal Haemoglobin E Level", "Normal Hemoglobin E Level" ; a owl:Class ; rdfs:label "Absent Hemoglobin E" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000180 obo:IAO_0000115 "A relationship that holds between a phenotype (i.e. manifestation) and a condition such as a disease (hemoglobinopathy), wherein the phenotype is evidence of the condition." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "manifestation of" ; rdfs:subPropertyOf obo:RO_0002201 . obo:SCDO_1000181 obo:IAO_0000115 "When the abnormal hemoglobin, hemoglobin E (HbE), has been detected in a blood sample." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin E Present", "Haemoglobin E in Blood", "HbE Present", "HbE in Blood", "Hemoglobin E in Blood" ; a owl:Class ; rdfs:label "Hemoglobin E Present" ; rdfs:subClassOf obo:HP_0020061 . obo:SCDO_1000182 obo:IAO_0000115 "A relation between a phenotype that is a symptom (subjective evidence of disease perceived by the patient) and a disease." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "symptom of" ; rdfs:subPropertyOf obo:RO_0002201 . obo:SCDO_1000183 obo:IAO_0000115 "A relationship between 'a' and 'b', where 'a' has some causal role for 'b'." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "causes or contributes to" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000184 obo:IAO_0000115 "A relationship between an entity (e.g. genetic variation such as mutation or specific allele) and a genotype, where the entity contributes to the genotype." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "contributes to genotype" ; rdfs:subPropertyOf obo:SCDO_1000183 . obo:SCDO_1000187 obo:IAO_0000115 "When the level of hemoglobin A2 detected in a sample of blood falls in the normal range for HbA2." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal Haemoglobin A2 Level", "Normal HbA2 Level", "Normal Hemoglobin A2 Concentration" ; a owl:Class ; rdfs:label "Normal Hemoglobin A2 Level" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000188 obo:IAO_0000115 "A relation between a condition (Hemoglobinopathy) and a form of research (type of study) that the condition was studied in." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "studied in" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000189 obo:IAO_0000115 "A relation between a condition (disease or phenotype) and a type of linking association (e.g. age of onset association)." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "associated via" . obo:SCDO_1000190 obo:IAO_0000115 "A relationship between a diagnostic measurement and the diagnostic tool used to produce the measurement." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "obtained via diagnostic tool" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000191 obo:IAO_0000115 "A relationship between a diagnostic device and the diagnostic tool by which the device is used." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "used by diagnostic tool" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000192 obo:IAO_0000115 "A relation between a diagnostic tool (test, method, assay, etc.) and a diagnostic device, where the diagnostic device is used in the application of the diagnostic tool." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "uses diagnostic device" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000193 obo:IAO_0000115 "A relation between a diagnostic measurement and a diagnostic device, where the diagnostic measurement is the output of the diagnostic device." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "output of diagnostic device" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000194 obo:IAO_0000115 "A relation between a diagnostic tool and the diagnostic measurement that it measures." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "measures" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000196 obo:IAO_0000115 "A relation between a genotype and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation contributes to the genotype." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has contributing genetic variation" ; rdfs:subPropertyOf obo:SCDO_0000660 . obo:SCDO_1000197 obo:IAO_0000115 "A test to detect both HIV antibodies and HIV antigens (a part of the virus) in blood." ; obo:SCDO_0000303 "Request inclusion into relevant ontology." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Khuthala Mnika)" ; oboInOwl:hasExactSynonym "Antibody/Antigen Tests" ; a owl:Class ; rdfs:comment "It can take 2 to 6 weeks for a person’s body to make enough antigens and antibodies for a combination test to detect HIV infection." ; rdfs:label "HIV Combination Test" ; rdfs:subClassOf obo:SCDO_0000571 . obo:SCDO_1000198 obo:IAO_0000115 "A test to detect HIV in a person's blood." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. The more specific term \"HIV-1 nucleic acid testing\" is found in the OBI." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Khuthala Mnika)" ; oboInOwl:hasExactSynonym "NAT" ; a owl:Class ; rdfs:comment """NATS can detect HIV infection about 7 to 28 days after a person has been infected with HIV. NATs are very expensive and not routinely used for HIV screening unless the person had a high-risk exposure or a possible exposure with early symptoms of HIV infection.""" ; rdfs:label "HIV Nucleic Acid Test" ; rdfs:subClassOf obo:SCDO_0000571 . obo:SCDO_1000199 obo:IAO_0000115 "A condition (phenotype or disease) or event (adverse event) induced by an entity (e.g. a drug) or activity (e.g. exercise)." ; obo:SCDO_0000303 "The \"developmentally induced by\" object property in RO has the alternative term \"induced by\"." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "induced by" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000201 obo:IAO_0000115 "An abnormal albumin excretion rate of more than 300 mg/g urine creatinine." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Macro-albuminuria", "Macroalbuminuria" ; a owl:Class ; rdfs:label "High Level Albuminuria" ; rdfs:subClassOf obo:SCDO_0000037 . obo:SCDO_1000202 obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (e.g. environment) or condition (phenotype or disease) which could be an existing condition or an event, where the entity or second condition has a causal role for the condition being described." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "caused by" ; rdfs:subPropertyOf obo:SCDO_0000660 . obo:SCDO_1000203 obo:IAO_0000115 "A relation between a condition (disease or phenotype) and an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of the condition." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has risk factor" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000204 obo:IAO_0000115 "A relation between an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of a condition and the condition (disease or phenotype) that it increases the likelihood of." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "risk factor for" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000205 obo:IAO_0000115 "A clinically severe form of sickle cell disease resulting when a person is homozygous for Hemoglobin C-Harlem." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Hemoglobin C-Harlem Disease" ; rdfs:subClassOf obo:SCDO_0008262, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001364 ; owl:someValuesFrom obo:HP_0000007 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000039 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000210 ; owl:someValuesFrom obo:SCDO_1000044 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000223 ; owl:someValuesFrom obo:SCDO_1000058 ] . obo:SCDO_1000206 obo:IAO_0000115 "Production of new arrangements of DNA by various mechanisms such as assortment and segregation, crossing over; gene conversion; genetic transformation; genetic conjugation; genetic transduction; or mixed infection of viruses." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000206" ; oboInOwl:hasDbXref "MESH:D011995" ; oboInOwl:hasExactSynonym "Recombination", "Recombination, Genetic" ; a owl:Class ; rdfs:label "Genetic Recombination" ; rdfs:subClassOf obo:SCDO_0001369 . obo:SCDO_1000207 obo:IAO_0000115 "An exchange of DNA between matching or similar sequences." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000207" ; oboInOwl:hasDbXref "MESH:D059765" ; oboInOwl:hasExactSynonym "Homologous Recombinations" ; a owl:Class ; rdfs:label "Homologous Recombination" ; rdfs:subClassOf obo:SCDO_1000206 . obo:SCDO_1000208 obo:IAO_0000115 "The reciprocal exchange of segments at corresponding positions along pairs of homologous chromosomes by symmetrical breakage and crosswise rejoining forming cross-over sites (Holliday junctions) that are resolved during chromosome segregation. Crossing-over typically occurs during meiosis but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes." ; obo:SCDO_0000303 "link this term to" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000208" ; oboInOwl:hasDbXref "MESH:D003434" ; oboInOwl:hasExactSynonym "Crossing Over, Genetic" ; a owl:Class ; rdfs:label "Genetic Crossing Over" ; rdfs:subClassOf obo:SCDO_1000207 . obo:SCDO_1000209 obo:IAO_0000115 "The homologous recombination event that occurs during meiosis and results in the delta beta globin fusion chains that replace hemoglobin subunit beta chains in the abnormal hemoglobin, Hemoglobin Lepore." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Crossover between delta (HBD) and beta globin (HBB) gene loci" ; rdfs:subClassOf obo:SCDO_1000208, [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0000343 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0000536 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003302 ; owl:someValuesFrom obo:SCDO_0001063 ], [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C141366 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000070 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000236 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000217 ; owl:someValuesFrom obo:SCDO_1000089 ] . obo:SCDO_1000210 obo:IAO_0000115 "A relation between a condition (disease or phenotype) or an entity (molecular phenotype) and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation has some causal or contributing role that influences the condition or entity." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has causal or contributing genetic variation" ; rdfs:subPropertyOf obo:SCDO_0000660 . obo:SCDO_1000211 obo:IAO_0000115 "Clinical sickle cell disease in the heterozygous state due to an additional mutation on the same allele as the beta S mutation." ; obo:SCDO_0000303 "Hemoglobin Jamaica Plain is an example of an abnormal hemoglobin structure caused by a double mutation in 1 Hb allele." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Dominant Sickle Cell Syndrome", "Dominant Sickle Syndrome" ; a owl:Class ; rdfs:comment """Often these individuals have co-inherited another hemoglobin mutation that decreases hemoglobin solubility (eg, HbS-Antilles; Hb-Quebec-Chori; HbS-Oman; Hb Jamaica Plain). Other rare causes of symptomatic sickle cell trait include: mosaicism for cells in which only the sickle mutation was expressed due to post-zygotic uniparental disomy, and when sickle cell trait coexists with pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling.""" ; rdfs:label "Dominant Sickle Cell Disease" ; rdfs:subClassOf obo:NCIT_C95534, obo:SCDO_0001051 . obo:SCDO_1000212 obo:IAO_0100001 obo:SCDO_1000164 ; a owl:Class ; rdfs:label "deprecated Disease Caused by A/Jamaica Plain Genotype" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000213 obo:IAO_0100001 obo:SCDO_1000165 ; dc:source ; a owl:Class ; rdfs:label "deprecated Disease Caused by A/S-Oman Genotype" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000214 obo:IAO_0100001 obo:SCDO_1000166 ; a owl:Class ; rdfs:label "deprecated Disease Caused by C/S Antilles Genotype" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000215 obo:IAO_0000115 "A hemoglobinopathy involving the presence of structurally abnormal hemoglobins and defects in the quantity of hemoglobins synthesised." ; obo:SCDO_0000303 "Probably too specific to the SCDO to be included in other ontologies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Structural and Quantitative Hemoglobinopathy" ; rdfs:subClassOf obo:SCDO_0000552 . obo:SCDO_1000217 obo:IAO_0000115 "A relation between an entity (genotype) and a molecular phenotype, where the entity has some causal or contributing role that influences the molecular phenotype." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "causes or contributes to molecular phenotype" ; rdfs:subPropertyOf obo:SCDO_1000183 . obo:SCDO_1000218 obo:IAO_0000115 "A relationship that holds between a condition such as a disease (hemoglobinopathy) and a phenotype (i.e. manifestation), where the phenotype is evidence of the condition." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has manifestation" ; rdfs:subPropertyOf obo:RO_0002200 . obo:SCDO_1000219 obo:IAO_0000115 "A relation between a condition that is a diagnosis and a phenotype used in making the diagnosis." ; a owl:ObjectProperty ; rdfs:label "diagnosed by" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000220 obo:IAO_0000115 "A relation between an Abnormal Phenotype that is a diagnosis and a Diagnostic Measurement or Diagnostic Device Visual Output used in making the diagnosis." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "diagnosed using measurement" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000221 obo:IAO_0000115 "A genotype whereby one of the four alpha-globin genes is faulty, either as a result of a single nucleotide variant (SNP) or of a deletion." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "-/alpha alpha/alpha" ; a owl:Class ; rdfs:label "Alpha Thalassemia Silent Genotype" ; rdfs:subClassOf obo:EUPATH_0000034, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C95536 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000239 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:HP_0011907 ] . obo:SCDO_1000222 obo:IAO_0000115 "A relation between a genotype and a molecular phenotype, where the genotype has a causal role for the molecular phenotype." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "causes molecular phenotype" ; rdfs:subPropertyOf obo:SCDO_1000183 . obo:SCDO_1000223 obo:IAO_0000115 "A relation between a condition (disease such as a Hemoglobinopathy) and a molecular phenotype, where the molecular phenotype is evidence of the condition." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "has causal molecular phenotype" ; rdfs:subPropertyOf obo:SCDO_0000660 . obo:SCDO_1000224 obo:IAO_0000115 "Increased susceptibility to bruising." ; obo:SCDO_0000303 """Suggest update to label of HPO's \"Bruising Susceptibility\". \"Bruising Susceptibility\" and \"Easy Bruisability\" are not actually the same thing.""" ; obo:SCDO_1000288 "Suggest update to label" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Bruisability, Bruising susceptibility, Easy bruising", "Bruise Easily", "Bruising Susceptibility", "Easy Bruising" ; a owl:Class ; rdfs:label "Easy Bruisability" ; rdfs:subClassOf obo:HP_0002597, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ] . obo:SCDO_1000225 obo:IAO_0000115 "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin C. Individuals with this genotype are known to be carriers of the hemoglobin C trait." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "AC Genotype", "AC Hemoglobin Genotype", "Haemoglobin Genotype AC", "Hemoglobin C Trait Genotype", "beta / beta6Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype AC" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000520 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000513 ] . obo:SCDO_1000226 obo:IAO_0000115 "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin D. Individuals with this genotype are known to be carriers of the hemoglobin D trait." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "AD Genotype", "AD Hemoglobin Genotype", "Haemoglobin Genotype AD", "Hemoglobin D Trait Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype AD" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000525 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000108 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000113 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000227 obo:IAO_0000115 "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin E. Individuals with this genotype are known to be carriers of the hemoglobin E trait." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Clair Ingram)" ; oboInOwl:hasExactSynonym "AE Genotype", "AE Hemoglobin Genotype", "Haemoglobin Genotype AE", "Hemoglobin E Trait Genotype", "beta / beta26Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype AE" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000531 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000009 ] . obo:SCDO_1000228 obo:IAO_0000115 "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin O-Arab. Individuals with this genotype are known to be carriers of the hemoglobin O-Arab trait." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "AO-Arab Genotype", "AO-Arab Hemoglobin Genotype", "Haemoglobin Genotype AO-Arab", "beta / beta121Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype AO-Arab" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000545 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000040 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000016 ] . obo:SCDO_1000229 obo:IAO_0000115 "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 26 of beta-globin chains (hemoglobin E mutation) produced by both beta-globin gene (HBB) alleles." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "EE Genotype", "EE Hemoglobin Genotype", "Haemoglobin Genotype EE", "Hemoglobin E Genotype", "beta6Glu>Lys / beta26Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype EE" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000530 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000042 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000009 ] . obo:SCDO_1000230 obo:IAO_0000115 "The homozygous genotype that involves a hemoglobin D mutation in both beta-globin gene (HBB) alleles." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "DD Genotype", "DD Hemoglobin Genotype", "Haemoglobin Genotype DD", "Hemoglobin C Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype DD" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000524 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000108 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000110 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000111 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000112 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000113 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000114 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000115 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000007 ] . obo:SCDO_1000231 obo:IAO_0000115 "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 121 of beta-globin chains (hemoglobin O-Arab mutation) produced by both beta-globin gene (HBB) alleles." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype O-Arab", "O-Arab Genotype", "O-Arab Hemoglobin Genotype", "beta121Glu>Lys / beta121Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype O-Arab" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000544 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000040 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_1000016 ] . obo:SCDO_1000232 obo:IAO_0000115 "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 6 of beta-globin chains (hemoglobin C mutation) produced by both beta-globin gene (HBB) alleles." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "CC Genotype", "CC Hemoglobin Genotype", "Haemoglobin Genotype CC", "Hemoglobin C Genotype", "beta6Glu>Lys / beta6Glu>Lys" ; a owl:Class ; rdfs:label "Hemoglobin Genotype CC" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000519 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000041 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:SCDO_0000513 ] . obo:SCDO_1000233 obo:IAO_0000115 "The presence of an amino acid substitution in either an alpha-, beta-, or gamma-globin chain such that its proximity to the heme iron in the hemoglobin molecule results in facilitated oxidation of the hemoglobin to yield excess methemoglobin. This can occur in either one or both alleles of the effected gene." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin Genotype M", "Hemoglobin M Genotype" ; a owl:Class ; rdfs:label "Hemoglobin Genotype M" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000541 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000238 ] . obo:SCDO_1000234 obo:SCDO_0000303 "Hemoglobin M Disease is autosomal dominant, thus does not seem to have a \"trait\" condition." ; a owl:Class ; rdfs:label "obsolete - Hemoglobin M trait Genotype" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000235 obo:IAO_0000115 "Either homozygosity or heterozygosity for the HPFH1 mutation, a 106-KB deletion in the beta globin gene cluster." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hereditary Persistence of Fetal Hemoglobin Genotype" ; rdfs:subClassOf obo:SCDO_0004061, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:NCIT_C129072 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_0006860 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000222 ; owl:someValuesFrom obo:HP_0011904 ] . obo:SCDO_1000236 obo:IAO_0000115 "The homozygous genotype for Hemoglobin Lepore Boston that involves a crossover between both sets of delta (HBD) and beta globin (HBB) gene loci during meiosis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hemoglobin Lepore Boston Genotype" ; rdfs:subClassOf obo:SCDO_0007624, [ a owl:Restriction ; owl:onProperty obo:RO_0003303 ; owl:someValuesFrom obo:SCDO_0000536 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000196 ; owl:someValuesFrom obo:SCDO_1000209 ] . obo:SCDO_1000237 obo:IAO_0000115 "The inheritance of one normal HBB gene along with an abnormal HBB gene that contains two amino acid substitutions, namely Glu6Val (HbS) and Asp73Asn." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Hb CH-Trait" ; a owl:Class ; rdfs:comment "Erythrocytes from persons with Hb CH trait show some sickling in hypertonic saline without deoxygenation; this finding and the renal functional abnormalities are similar to those seen in persons with sickle cell trait and suggest that the renal concentrating defects in the two disorders have similar pathogeneses." ; rdfs:label "Hemoglobin C-Harlem Trait" ; rdfs:subClassOf obo:NCIT_C95534 . obo:SCDO_1000238 obo:IAO_0000115 "A mutation in the NADH-Cytochrome b5 Reductase 3 gene, CYB5R3, that contributes to the presence of methemoglobinemia (type I or II)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; oboInOwl:hasExactSynonym "DIA 1 Mutation", "Diaphorase Mutation", "Methemoglobinemia Mutation", "NADH-Cytochrome b5 Reductase 3 Mutation" ; a owl:Class ; rdfs:label "CYB5R3 Mutation" ; rdfs:subClassOf obo:IDOMAL_50000026, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000233 ] . obo:SCDO_1000239 obo:IAO_0000115 "Deletion of one alpha-globin gene, either an HBA1 or HBA2 gene, which results in Alpha Thalassemia Silent (the person with the mutation is a silent carrier)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Heterozygous Deletion of HBA1 or HBA2" ; rdfs:subClassOf obo:SCDO_0001386, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000184 ; owl:someValuesFrom obo:SCDO_1000221 ] . obo:SCDO_1000240 obo:IAO_0000115 "Either a decrease in the proportion of hemoglobin A to below 96-98% of all hemoglobin, or a complete lack of hemoglobin A production." ; obo:SCDO_0000303 "Probably too specific to be added to existing ontologies?" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Reduced or Absent Hemoglobin A" ; rdfs:subClassOf obo:SCDO_1000061 . obo:SCDO_1000241 obo:IAO_0000115 "A lack of production of normal adult hemoglobin." ; obo:SCDO_0000303 "Request inclusion into HPO below \"Abnormal Hemoglobin Concentration\"." ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hemoglobin A Absent" ; a owl:Class ; rdfs:label "Absent Hemoglobin A" ; rdfs:subClassOf obo:HP_0020061, obo:SCDO_1000061 . obo:SCDO_1000242 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are homozygotes (having two copies of the same mutant allele)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Autosomal Homozygous Recessive Inheritance" ; a owl:Class ; rdfs:label "Autosomal Recessive Homozygous" ; rdfs:subClassOf obo:HP_0000007 . obo:SCDO_1000243 obo:IAO_0000115 "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Autosomal Recessive Compound Heterozygous Inheritance" ; a owl:Class ; rdfs:label "Autosomal Recessive Compound Heterozygous" ; rdfs:subClassOf obo:HP_0000007 . obo:SCDO_1000244 obo:IAO_0000115 "A sickle cell disease phenotype in which an individual heterozygous for hemoglobin S also has a severe pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source , ; a owl:Class ; rdfs:label "Sickle Cell Trait with a Severe Pyruvate Kinase Deficiency" ; rdfs:subClassOf obo:SCDO_1000211 . obo:SCDO_1000247 obo:IAO_0000115 "A powder form of the optically active form of glutamine having L-configuration; to be administered orally." ; obo:SCDO_0000303 "Suggest update to description in the Drug Ontology (DRON) for \"Glutamine Oral Powder\" (currently no description provided)." ; obo:SCDO_0000340 obo:CHEBI_18050, ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Glutamine Oral Powder", "Glutamine Oral Powder Product", "Glutamine Powder", "L-Glutamine Powder", "Oral Glutamine" ; a owl:Class ; rdfs:comment "Oral administration of L-glutamine oral powder is approved by the FDA to reduce the acute complications of sickle cell disease and sickle beta zero-thalassemia in adult and pediatric patients." ; rdfs:label "L-Glutamine Oral Powder" ; rdfs:subClassOf obo:CHEBI_23888, obo:SCDO_0001133 . obo:SCDO_1000250 obo:IAO_0000115 "A phenotype in which a specific molecular function is abnormal." ; obo:SCDO_0000340 obo:FYPO_0000707 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000250" ; oboInOwl:hasDbXref "FYPO:0000707" ; a owl:Class ; rdfs:label "deprecated Abnormal Molecular Function" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000251 obo:IAO_0000115 "An increase in red blood cell sensitivity to change in osmotic pressure. More specifically, the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to osmotic stress by being placed in a hypotonic solution." ; obo:SCDO_0000303 """What is normal osmotic fragility? Perhaps this can be included in the description. Suggest update to description in the HPO. Currently no description given. Include \"Osmotic Fragility Test\" in an appropriate location below \"Diagnostics Tools\" and link to this term.""" ; obo:SCDO_0000340 , obo:HP_0005502, ; obo:SCDO_1000288 "Suggest update to description." ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "HP:0005502" ; oboInOwl:hasExactSynonym "Increased Erythrocyte Osmotic Fragility", "Increased Red Cell Fragility" ; a owl:Class ; rdfs:label "Increased Red Cell Osmotic Fragility" ; rdfs:subClassOf obo:HP_0020054 . obo:SCDO_1000252 obo:SCDO_0000303 """Is this not the same as \"Increased Red Cell Osmotic Fragility\"? See dc:source provided. What is normal osmotic resistance? Perhaps this can be included in the description. Suggest update to description in the HPO. Currently no description given. Include \"Osmotic Fragility Test\" in an appropriate location below \"Diagnostics Tools\" and link to this term.""" ; obo:SCDO_0000340 obo:HP_0005546 ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "HP:0005546" ; a owl:Class ; rdfs:label "Increased Red Cell Osmotic Resistance" ; rdfs:subClassOf obo:HP_0020054 . obo:SCDO_1000253 obo:IAO_0000115 "A situation in which a specific biological process within an organism is abnormal." ; obo:SCDO_0000303 """Include here \"Intrahepatic Sinusoidal Sickling\"? See paper \"Liver involvement in sickle cell disease\" by Emel GÜRKAN et al.""" ; obo:SCDO_0000340 obo:FYPO_0005447 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000253" ; oboInOwl:hasDbXref "FYPO:0005447" ; a owl:Class ; rdfs:label "Abnormal Biological Process" ; rdfs:subClassOf obo:HP_0000118 . obo:SCDO_1000254 obo:IAO_0000115 "When deoxygenated, malfunctioning or mutated hemoglobins clump together and form a long polymer." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hemoglobin Polymerisation" ; a owl:Class ; rdfs:label "Polymerisation of Hemoglobin" ; rdfs:subClassOf obo:SCDO_1000253 . obo:SCDO_1000255 obo:IAO_0000115 "Guidelines that examine current available evidence on indications for transfusion in sickle cell disease." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Br J Haematol. 2017 Jan;176(2):192-209. doi: 10.1111/bjh.14383. Epub 2016 Nov 18." ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Guidelines on Red Cell Transfusion in Sickle Cell Disease - Part II: Indications for Transfusion" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000256 obo:IAO_0000115 "This guideline addresses the management of an acute painful sickle cell episode in patients presenting to hospital until discharge. This includes the use of pharmacological and non-pharmacological interventions, identifying the signs and symptoms of acute complications, skills and settings for managing an acute painful episode, and the information and support needs of patients." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; dc:source ; a owl:Class ; rdfs:label "Sickle Cell Acute Painful Episode - Management of an Acute Painful Sickle Cell Episode in Hospital" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000257 obo:IAO_0000115 "A factsheet that shares steps to improve care in emergency departments (ED) of hospitals and clinics for people with sickle cell disease (SCD). It was created to help improve healthcare in the ED for patients with SCD." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Three Tips About Sickle Cell Disease Every Emergency Provider Needs to Know" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000258 obo:IAO_0000115 "A comprehensive guideline to aid physicians and other health care professionals in the management of patients with acute and chronic pain associated with sickle cell disease (SCD). The guideline covers the following information: an overview of the disease, the types and characteristics of pain associated with the disease, recommendations for pain assessment, methods for treatment of pain and a discussion of pain in the various developmental stages. It also includes discussions of pain assessment instruments." ; obo:SCDO_0000303 "Probably not necessary to include in other ontologies." ; obo:SCDO_0000340 "Am Fam Physician. 2000 Mar 1;61(5):1544-1550." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Practice Guidelines: Management of Pain in Sickle Cell Disease" ; rdfs:subClassOf obo:SCDO_1000143 . obo:SCDO_1000259 obo:IAO_0000115 "A hemoglobin that shows characteristics of an abnormal hemoglobin, but its inheritance does not accompany any disability." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Hemoglobin Variant\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Unusual Hemoglobin Variant" ; a owl:Class ; rdfs:label "Unusual Hemoglobin" ; rdfs:subClassOf obo:SCDO_0006921 . obo:SCDO_1000260 obo:IAO_0000115 "Any feeling of illness or physical or mental change that results from strenuous exercise." ; obo:SCDO_0000303 "Suggest update to description in OMIM (currently no description provided)." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source , ; oboInOwl:hasDbXref "OMIM:MTHU024836" ; a owl:Class ; rdfs:label "Symptom Induced by Strenuous Exercise" ; rdfs:subClassOf obo:HP_0000118 . obo:SCDO_1000261 obo:IAO_0000115 "A condition due to a deficiency of one or more essential vitamins. (Dorland, 27th ed)" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000261" ; oboInOwl:hasDbXref "MESH:D001361" ; oboInOwl:hasExactSynonym "Vitamin Deficiencies", "Vitamin Deficiency" ; a owl:Class ; rdfs:label "Avitaminosis" ; rdfs:subClassOf obo:HP_0000118 . obo:SCDO_1000268 obo:IAO_0000115 "Abnormality originating in one or more muscles of the set of muscles in the body." ; obo:SCDO_0000340 obo:HP_0003011 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0003011" ; a owl:Class ; rdfs:label "Abnormality of the Musculature" ; rdfs:subClassOf obo:HP_0000118 . obo:SCDO_1000276 obo:IAO_0000115 "An abnormal level of hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD)." ; obo:SCDO_0000303 "Probably too specific to SCD be included in other ontologies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Abnormal Hemoglobin Level in SCD" ; rdfs:subClassOf obo:SCDO_1000060 . obo:SCDO_1000280 obo:IAO_0000115 "Hemochromatosis that results from repeated blood transfusions." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; oboInOwl:hasExactSynonym "Transfusion Haemochromatosis", "Transfusion-Induced Iron Overload" ; a owl:Class ; rdfs:label "Transfusion Hemochromatosis" ; rdfs:subClassOf obo:SCDO_1000281 . obo:SCDO_1000281 obo:IAO_0000115 "An acquired metabolic disorder characterized by iron accumulation in the tissues." ; obo:SCDO_0000303 "Suggest inclusion into existing ontology." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Secondary Hemochromatosis" ; rdfs:subClassOf obo:NCIT_C78393 . obo:SCDO_1000288 obo:IAO_0000115 "An indication of whether a term/class already exists in other ontologies. Only used for term (descriptions) that were not taken directly from an existing ontology." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:comment """Annotation options: Negligable Not relevant to context of sickle cell Few but definitions not freely available Suggest update to description Suggest update to label None""" ; rdfs:label "existence in other ontologies" . obo:SCDO_1000289 obo:IAO_0000115 "When the abnormal hemoglobin, hemoglobin D-Punjab (Hb D-Punjab), has been detected in a blood sample." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin D-Punjab Present", "Haemoglobin D-Punjab in Blood", "Hb D-Punjab Present", "Hb D-Punjab in Blood", "Hemoglobin D-Punjab in Blood" ; a owl:Class ; rdfs:label "Hemoglobin D-Punjab Present" ; rdfs:subClassOf obo:HP_0020061 . obo:SCDO_1000290 obo:IAO_0000115 "When the abnormal hemoglobin, hemoglobin G-Philadelphia (Hb G-Philadelphia), has been detected in a blood sample." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin G-Philadelphia Present", "Haemoglobin G-Philadelphia in Blood", "Hb G-Philadelphia Present", "Hb G-Philadelphia in Blood", "Hemoglobin G-Philadelphia in Blood" ; a owl:Class ; rdfs:label "Hemoglobin G-Philadelphia Present" ; rdfs:subClassOf obo:HP_0020061 . obo:SCDO_1000291 obo:IAO_0000115 "When the abnormal hemoglobin, hemoglobin O-Arab (Hb O-Arab), has been detected in a blood sample." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin O-Arab Present", "Haemoglobin O-Arab in Blood", "Hb O-Arab Present", "Hb O-Arab in Blood", "Hemoglobin O-Arab in Blood" ; a owl:Class ; rdfs:label "Hemoglobin O-Arab Present" ; rdfs:subClassOf obo:HP_0020061 . obo:SCDO_1000292 obo:IAO_0000115 "When the level of hemoglobin F detected in a sample of blood falls in the normal range for HbF." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal Haemoglobin F Level", "Normal HbF Level", "Normal Hemoglobin F Concentration" ; a owl:Class ; rdfs:label "Normal Hemoglobin F Level" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000295 obo:IAO_0000115 "The score obtained from a quality of life-related diagnostic instrument." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Quality of Life Score" ; a owl:Class ; rdfs:label "Quality of Life Assessment Score" ; rdfs:subClassOf obo:SCDO_1000318 . obo:SCDO_1000296 obo:IAO_0000115 "The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me) diagnostic instrument." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "ASCQ-Me - Quality of Life in SCD Score", "Sickle Cell Disease Adult Quality of Life Questionnaire Assessment Score" ; a owl:Class ; rdfs:label "ASCQ-Me Score" ; rdfs:subClassOf obo:SCDO_1000295 . obo:SCDO_1000297 obo:IAO_0000115 "A diagnostic instrument that involves an assessment of quality of life- and/or quality of care-related elements." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Quality of Life and Care Diagnostic Instrument" ; rdfs:subClassOf obo:SCDO_1000033 . obo:SCDO_1000298 obo:IAO_0000115 "A deteremination of the presence of hepatitis B virus surface antigen." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Surface Antigen Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; dc:source ; oboInOwl:hasDbXref "NCIT:C64850" ; oboInOwl:hasExactSynonym "HBSAG Test", "HBsAg Test", "Hepatitis B Surface Antigen Test", "Hepatitis B Virus Surface Antigen Measurement" ; a owl:Class ; rdfs:comment """If a person tests “positive,” then further testing is needed to determine if this is a new “acute” infection or a “chronic” hepatitis B infection. A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood.""" ; rdfs:label "Hepatitis B Virus Surface Antigen Test" ; rdfs:subClassOf obo:SCDO_0000616 . obo:SCDO_1000299 obo:IAO_0000115 "The determination of the surface antibody reaction of a sample to the Hepatitis B virus." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis B Surface Antibody Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C74711" ; oboInOwl:hasExactSynonym "HBSAB Test", "HBsAb Test", "Hepatitis B Virus Surface Antibody Test", "anti-HBs Test" ; a owl:Class ; rdfs:comment ; rdfs:label "Hepatitis B Surface Antibody Test" ; rdfs:subClassOf obo:SCDO_1000302 . obo:SCDO_1000300 obo:IAO_0000115 "The determination of the amount of Hepatitis B virus core antibody present in a sample." ; obo:SCDO_0000303 "Suggest update to label in nCIT (from \"Hepatitis B Virus Core Antibody Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; dc:source ; oboInOwl:hasDbXref "NCIT:C96660" ; oboInOwl:hasExactSynonym "Anti-HBc Test", "HBCAB Test", "HBcAB Test", "Hepatitis B Virus Core Antibody Test" ; a owl:Class ; rdfs:comment """A \"positive\" or \"reactive\" anti-HBc (or HBcAb) test result indicates a past or current hepatitis B infection. The core antibody does not provide any protection against the hepatitis B virus (unlike the surface antibod). This test can only be fully understood by knowing the results of the HBsAg and anti-HBs tests. A positive anti-HBc (or HBcAb) test result requires talking to your health care provider for a complete explanation of your hepatitis B status.""" ; rdfs:label "Hepatitis B Core Antibody Test" ; rdfs:subClassOf obo:SCDO_1000302 . obo:SCDO_1000301 obo:IAO_0000115 "A set of three blood tests (Hepatitis B Core Antibody Test, Hepatitis B Surface Antibody Test, and Hepatitis B Virus Surface Antigen Test) needed to fully understand whether a person is infected with Hepatitis B or not." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Hepatitis B Panel", "Hepatitis B Panel of Blood Tests" ; a owl:Class ; rdfs:label "Hepatitis B Blood Panel" ; rdfs:subClassOf obo:SCDO_0000616 . obo:SCDO_1000302 obo:IAO_0000115 "The determination of the amount of hepatitis B virus antibody present in a sample." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Antibody Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C125944" ; oboInOwl:hasExactSynonym "HBAB Test", "Hepatitis B Antibody Test" ; a owl:Class ; rdfs:label "Hepatitis B Virus Antibody Test" ; rdfs:subClassOf obo:SCDO_0000616 . obo:SCDO_1000303 obo:IAO_0000115 "The determination of the amount of hepatitis B virus core IgG antibody in a biological specimen." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Core IgG Antibody Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C119280" ; oboInOwl:hasExactSynonym "HBCIGGAB Test", "Hepatitis B Virus Core IgG Antibody Test" ; a owl:Class ; rdfs:label "Hepatitis B Core IgG Antibody Test" ; rdfs:subClassOf obo:SCDO_1000300 . obo:SCDO_1000304 obo:IAO_0000115 "The determination of the amount of Hepatitis B virus core IgM antibody present in a sample." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Core IgM Antibody Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C96661" ; oboInOwl:hasExactSynonym "HBCIGMAB Test", "Hepatitis B Virus Core IgM Antibody Test" ; a owl:Class ; rdfs:label "Hepatitis B Core IgM Antibody Test" ; rdfs:subClassOf obo:SCDO_1000300 . obo:SCDO_1000305 obo:IAO_0000115 "Exercise testing for evaluation of hypoxemia and/or desaturation that occurs on exertion." ; obo:SCDO_0000303 "Suggest inclusion of term below \"Pulse Oximetry\" in the CMO." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Pulse Oximetry (Exercise) #91001" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000305" ; oboInOwl:hasDbXref "phenX:91001" ; a owl:Class ; rdfs:label "Pulse Oximetry (Exercise)" ; rdfs:subClassOf obo:NCIT_C38085 . obo:SCDO_1000306 obo:IAO_0000115 "The determination of the amount of hepatitis C virus antigen present in a sample." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis C Virus Antigen Measurement\"" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C116196" ; oboInOwl:hasExactSynonym "HCAG Test", "Hepatitis C Virus Antigen Measurement" ; a owl:Class ; rdfs:label "Hepatitis C Virus Antigen Test" ; rdfs:subClassOf obo:SCDO_0000616 . obo:SCDO_1000307 obo:IAO_0000115 "A determination of the presence of the hepatitis C virus antibody in a biological specimen." ; obo:SCDO_0000303 "Suggest update to label and description in NCIT (from \"Hepatitis C Antibody Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label and description" ; oboInOwl:hasDbXref "NCIT:C92535" ; oboInOwl:hasExactSynonym "HCAB Test", "Hepatitis C Antibody Measurement", "Hepatitis C Virus Antibody Test" ; a owl:Class ; rdfs:label "Hepatitis C Antibody Test" ; rdfs:subClassOf obo:SCDO_0000616 . obo:SCDO_1000308 obo:IAO_0000115 "The determination of the amount of hepatitis C virus core antigen in a biological sample." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis C Virus Core Antigen Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C135424" ; oboInOwl:hasExactSynonym "HCCAG Test", "HCV Core Antigen Measurement", "HCV Core Antigen Test", "Hepatitis C Core Antigen Test", "Hepatitis C Virus Core Antigen Measurement" ; a owl:Class ; rdfs:label "Hepatitis C Virus Core Antigen Test" ; rdfs:subClassOf obo:SCDO_1000306 . obo:SCDO_1000309 obo:IAO_0000115 "The determination of the surface antibody reaction of a sample to the Hepatitis C virus." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Hepatitis C Surface Antibody Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C74712" ; oboInOwl:hasExactSynonym "Hepatitis C Surface Antibody Measurement" ; a owl:Class ; rdfs:label "Hepatitis C Surface Antibody Test" ; rdfs:subClassOf obo:SCDO_1000307 . obo:SCDO_1000310 obo:IAO_0000115 "The determination of the amount of cystatin C present in a sample." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Cystatin C Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C92290" ; oboInOwl:hasExactSynonym "CYSTATC Blood Test" ; a owl:Class ; rdfs:label "Cystatin C Blood Test" ; rdfs:subClassOf obo:SCDO_0000133, obo:SCDO_0000676, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000310 ] . obo:SCDO_1000313 obo:IAO_0000115 "The visual output that a specific diagnostic device produces." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Visual Output of a Diagnostic Device" ; a owl:Class ; rdfs:label "Diagnostic Device Visual Output" ; rdfs:subClassOf obo:SCDO_0000379 . obo:SCDO_1000314 obo:IAO_0000115 "A bioassay to measure levels of red blood cell microparticles." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Red Blood Cell Microparticles Assay" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000975 ] . obo:SCDO_1000315 obo:IAO_0000115 "A quantitative measurement of the amount of HDL cholesterol present in a sample of serum." ; obo:SCDO_0000303 "Suggest update to label in NCIT (from \"Serum HDL Cholesterol Measurement\")" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "NCIT:C61041" ; oboInOwl:hasExactSynonym "Serum HDL Cholesterol Measurement" ; a owl:Class ; rdfs:label "Serum HDL Cholesterol Test" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0001043 ] . obo:SCDO_1000316 obo:IAO_0000115 "A technique used to measure velocity and amount of blood flow and circulation in the living system." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Blood Flow Test" ; rdfs:subClassOf obo:SCDO_0000902 . obo:SCDO_1000317 obo:IAO_0000115 "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart." ; obo:SCDO_0000303 "Suggest this description for this term in the CMO (it was recently described separately from another similar term\" but's it's definition has not yet been ascribed)." ; obo:SCDO_0000340 obo:CMO_0000670 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "CMO:0000670" ; a owl:Class ; rdfs:label "Heart Measurement" ; rdfs:subClassOf obo:CMO_0000001 . obo:SCDO_1000318 obo:IAO_0000115 "An information entity, used in the diagnosis of medical conditions, that is a recording of the output of a diagnostic instrument." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Add terms/Variables obtained from: History of Head Trauma Diagnostic Instrument""" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Diagnostic Instrument Outcome" ; a owl:Class ; rdfs:label "Diagnostic Instrument Measurement" ; rdfs:subClassOf obo:SCDO_0000728 . obo:SCDO_1000319 obo:IAO_0000115 "Questions asking the respondent about smoking status in his or her entire life." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; a owl:Class ; rdfs:label "Cigarette Smoking Status Diagnostic Instrument" ; rdfs:subClassOf obo:SCDO_1000033 . obo:SCDO_1000320 obo:IAO_0000115 "Questions asking an adult respondent about smoking status in his or her entire life." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000479 "PhenX protocol: Cigarette Smoking Status - Adult #30604" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Cigarette Smoking Status Diagnostic Instrument - Adult" ; rdfs:subClassOf obo:SCDO_1000319, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000235 ] . obo:SCDO_1000321 obo:IAO_0000115 "Questions asking an adolescentt respondent about smoking status in his or her entire life." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_0000479 "PhenX protocol: Cigarette Smoking Status - Adolescent #30603" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Cigarette Smoking Status Diagnostic Instrument - Adolescent" ; rdfs:subClassOf obo:SCDO_1000319, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000235 ] . obo:SCDO_1000322 obo:IAO_0000115 "A person who has never smoked a cigarette, not even one or two puffs." ; obo:SCDO_0000303 "Other ontologies define this as \"A person who was not smoking at the time of the interview and has smoked less than 100 cigarettes in their life.\"" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Never Smoker" ; rdfs:subClassOf obo:SCDO_0000235 . obo:SCDO_1000323 obo:IAO_0000115 "A person who was smoking on a daily basis at the time of the interview." ; obo:SCDO_0000303 "Other ontologies define this as \"Indicates a person who has smoked at least 100 cigarettes in his or her lifetime and who currently smokes every day.\"" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Current Every-Day Smoker" ; rdfs:subClassOf obo:SCDO_0000235 . obo:SCDO_1000324 obo:IAO_0000115 "A person who had smoked a cigarette in the past, and was smoking on some days, but not daily, at the time of the interview." ; obo:SCDO_0000303 "Other ontologies define this as \"Indicates a person who has smoked at least 100 cigarettes in his or her lifetime, who smokes now, but does not smoke every day.\"" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Current Some-Day Smoker" ; rdfs:subClassOf obo:SCDO_0000235 . obo:SCDO_1000325 obo:IAO_0000115 "A person who was not smoking at the time of the interview but has smoked a cigarette in the past, even if just one or two puffs" ; obo:SCDO_0000303 "Other ontologies define this as \"A person who was not smoking at the time of the interview but has smoked at least 100 cigarettes in their life.\"" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Former Smoker" ; rdfs:subClassOf obo:SCDO_0000235 . obo:SCDO_1000326 obo:IAO_0000115 "A person who has smoked a cigarette in the past, even if just one or two puffs, but was unable to or refused to answer when asked when the last time was that they smoked a cigarette, even one or two puffs." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Ever-Smoker" ; rdfs:subClassOf obo:SCDO_0000235 . obo:SCDO_1000327 obo:IAO_0000115 "A person who had smoked in the past 30 days at the time of the interview, but who had not smoked every day of the past 30 days." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Past 30-Day Smoker" ; rdfs:subClassOf obo:SCDO_0000235 . obo:SCDO_1000328 obo:IAO_0000115 "A person who had smoked every day of the past 30 days at the time of the interview." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Past 30-Day Every-Day Smoker" ; rdfs:subClassOf obo:SCDO_0000235 . obo:SCDO_1000329 obo:IAO_0000115 "Question asking the respondent if s/he has ever consumed any alcoholic beverage during his or her entire life." ; obo:SCDO_0000303 "Suggest update to label in PhenX" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: #30101" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:030100" ; a owl:Class ; rdfs:label "Alcohol - Lifetime Use Diagnostic Instrument" ; rdfs:subClassOf obo:SCDO_1000474, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000038 ] . obo:SCDO_1000330 obo:IAO_0000115 "A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in adults." ; obo:SCDO_0000303 """Request inclusion into \"PhenX Phenotypic Terms\". This is in the PhenX toolkit but not in the ontology in BioPortal. It should probably be included there.""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "phenX:130401" ; oboInOwl:hasExactSynonym "Epilepsy Screener for Adults" ; a owl:Class ; rdfs:label "Epilepsy Screener - Adult" ; rdfs:subClassOf obo:SCDO_0000440 . obo:SCDO_1000331 obo:IAO_0000115 "A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in family members, including children and those who are deceased." ; obo:SCDO_0000303 """Request inclusion into \"PhenX Phenotypic Terms\". This is in the PhenX toolkit but not in the ontology in BioPortal. It should probably be included there.""" ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "phenX:130402" ; oboInOwl:hasExactSynonym "Family History of Epilepsy Screening Interview", "Ottman Brief Epilepsy Screener - Proxy-reported Version" ; a owl:Class ; rdfs:label "Epilepsy Screener - Child/Proxy" ; rdfs:subClassOf obo:SCDO_0000440 . obo:SCDO_1000332 obo:IAO_0000115 "A disruption to the efficacy of the executive functions, which is a group of cognitive processes that regulate, control, and manage other cognitive processes." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. Perhaps below \"Behavioral Abnormality\" in the HPO." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "Defects in Executive Function", "Executive Function Deficit" ; a owl:Class ; rdfs:label "Executive Dysfunction" ; rdfs:subClassOf obo:HP_0000708, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000663 ; owl:someValuesFrom obo:SCDO_0001304 ] . obo:SCDO_1000333 obo:IAO_0000115 "A series of 21 age-specific questionnaires and scoring sheets designed to screen a child's skills in five developmental areas: fine motor, gross motor, problem solving, communication, and personal-social. A child's scores for each area are compared to cut-off scores to determine a need for monitoring or further assessment." ; obo:SCDO_0000303 "Request inclusion into relevant ontology. Maybe below \"Clinical or Research Assessment Questionnaire\" in the NCIT." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "Global Mental Status Screener - Child #130702" ; obo:SCDO_1000288 "Few but definitions not freely available" ; oboInOwl:hasExactSynonym "The Ages & Stages Questionnaires, Third Edition (ASQ-3)" ; a owl:Class ; rdfs:label "Global Mental Status Screener - Child" ; rdfs:subClassOf obo:SCDO_0000455 . obo:SCDO_1000336 obo:IAO_0000115 "The frequency of acute pain episodes due to sickle cell disease (SCD)." ; obo:SCDO_0000303 """Request inclusion into relevant ontology Add as sub-classes: (from protocol questions) - a term for the number of times an emergency room was visited because of a sickle cell painful event in the last 6 months - a term for the number of times the person was admitted to a hospital because of a sickle cell painful event in the last 12 months""" ; obo:SCDO_1000288 "Not relevant to context of sickle cell. This term in PhenX currently refers to a diagnostic instrument." ; a owl:Class ; rdfs:label "Frequency of Sickle Cell Pain Episodes" ; rdfs:subClassOf obo:SCDO_1000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000725 ] . obo:SCDO_1000337 obo:IAO_0000115 "Questions from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) related to their lifetime use of illicit and prescribed substances." ; obo:SCDO_0000303 "Suggest update to label in PhenX" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Substances - Lifetime Use #31102" ; obo:SCDO_1000288 "Suggest update to label" ; a owl:Class ; rdfs:label "Substances - Lifetime Use Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0001121 ] . obo:SCDO_1000338 obo:IAO_0000115 "A 26-item, self-administered scale completed by the parent that assesses the child's sleep behaviors in the past 6 months. The scale includes six subscales: disorders of initiating and maintaining sleep (items 1, 2, 3, 4, 5, 10, 11); sleep breathing disorders (items 13, 14, 15); disorders of arousal (items 17, 20, 21); sleep-wake transition disorders (items 6, 7, 8, 12, 18, 19); disorders of excessive somnolence (items 22, 23, 24, 25, 26); and sleep hyperhidrosis (score of the items 9, 16). Each item is rated on a 5-point, Likert-type scale (1 = Never; 5 = Always [daily]). Scores from individual items of each subscale are added together to give a subscale score, with higher scores indicating greater symptoms. Scores from the individual subscales can be added together to give a total score." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Separate adult vs children instruments not shown in \"PhenX Phenotypic Terms\".""" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Sleep Disorders Screener - Children #121002" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "phenX:121002" ; oboInOwl:hasExactSynonym "Sleep Disturbances Scale for Children" ; a owl:Class ; rdfs:label "Sleep Disorders Screener - Children" ; rdfs:subClassOf obo:SCDO_1000348 . obo:SCDO_1000339 obo:IAO_0000115 "A record of an individual's background in regard to head trauma." ; obo:SCDO_0000303 """Request inclusion into relevant ontology. Perhaps as a sub-class of \"History of Trauma\" in \"The Stroke Ontology\"? PhenX uses this as their label for a questionnaire, but we're going to suggest they change that. Otherwise, don't see it in other ontologies.""" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "History of Head Trauma" ; rdfs:subClassOf obo:NCIT_C18772 . obo:SCDO_1000340 obo:IAO_0000115 "A record of an individual's history of stroke(s) and associated symptoms such as slurred speech, double vision, loss of vision, and paralysis." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Personal Medical History\". Note: Is present in The Stroke Ontology." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "History of Stroke" ; rdfs:subClassOf obo:NCIT_C18772 . obo:SCDO_1000341 obo:IAO_0000115 "A record of an individual's history of kidney failure." ; obo:SCDO_0000303 """Request inclusion into NCIT as a sub-class of \"Personal Medical History\". PhenX uses this as their label for a questionnaire, but we're going to suggest they change that. Otherwise, don't see it in other ontologies.""" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "History of Kidney Failure" ; rdfs:subClassOf obo:NCIT_C18772 . obo:SCDO_1000342 obo:IAO_0000115 "A questionnaire to assess history of transfusion." ; obo:SCDO_0000303 "Suggest update to label as we have done. We are using \"History of Transfusion\" below Personal Attribute." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: History of Transfusion #830201" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:830200" ; a owl:Class ; rdfs:label "History of Transfusion Diagnostic Instrument" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033, [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:NCIT_C17357 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0001297 ; owl:someValuesFrom obo:SCDO_0000304 ] . obo:SCDO_1000343 obo:IAO_0000115 "A record of an individual's history of type 1 and type 2 diabetes." ; obo:SCDO_0000303 """Request inclusion into NCIT as a sub-class of \"Personal Medical History\". PhenX uses this as their label for a questionnaire, but we're going to suggest they change that. Otherwise, don't see it in other ontologies.""" ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "History of Type 1 and Type 2 Diabetes" ; rdfs:subClassOf obo:NCIT_C18772 . obo:SCDO_1000344 obo:IAO_0000115 "A questionnaire to assess males' pregnancy history." ; obo:SCDO_0000303 "Suggest update to label and description in PhenX as we have done. We are using \"Reproductive History\" below Personal Attribute." ; obo:SCDO_0000479 "PhenX protocol: Reproductive History - Male #101302" ; obo:SCDO_1000288 "Suggest update to label and description." ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Reproductive History Diagnostic Instrument - Male" ; rdfs:subClassOf obo:SCDO_0000987 . obo:SCDO_1000345 obo:IAO_0000115 "A questionnaire to assess females' pregnancy history." ; obo:SCDO_0000303 "Suggest update to label and description in PhenX as we have done. We are using \"Reproductive History\" below Personal Attribute." ; obo:SCDO_0000479 "PhenX protocol: Reproductive History - Female #101301" ; obo:SCDO_1000288 "Suggest update to label and description." ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Reproductive History Diagnostic Instrument - Female" ; rdfs:subClassOf obo:SCDO_0000987 . obo:SCDO_1000348 obo:IAO_0000115 "A questionnaire to assess sleep disorders, a broad group of disorders that can be caused by endogenous disturbances in the sleep-wake or timing cycles (American Psychiatric Association, 2000)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000348" ; oboInOwl:hasDbXref "phenX:121000" ; a owl:Class ; rdfs:label "Sleep Disorders Screener" ; rdfs:subClassOf obo:NCIT_C91105, obo:SCDO_1000033 . obo:SCDO_1000350 obo:IAO_0000115 "A test to assess the structure and function of the heart valves." ; obo:SCDO_0000303 "Suggest update to label in PhenX (from \"Heart Valve Function\")" ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Heart Valve Function #40501" ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "phenX:40501" ; a owl:Class ; rdfs:label "Heart Valve Function Test" ; rdfs:subClassOf obo:SCDO_0000500, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:SCDO_0000502 ] . obo:SCDO_1000352 obo:IAO_0000115 "Measurement of the breathing capacity of an adult's lung by means of a spirometer." ; obo:SCDO_0000303 "Suggest update to description in PhenX (currently the same for both adult and child protocols)" ; obo:SCDO_0000479 "PhenX protocol: Spirometry - Adult #91601" ; obo:SCDO_1000288 "Suggest update to description" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Spirometry - Adult" ; rdfs:subClassOf obo:NCIT_C85397 . obo:SCDO_1000353 obo:IAO_0000115 "Measurement of the breathing capacity of a child's lung by means of a spirometer." ; obo:SCDO_0000303 "Suggest update to description in PhenX (currently the same for both adult and child protocols)" ; obo:SCDO_0000479 "PhenX protocol: Spirometry - Child #91602" ; obo:SCDO_1000288 "Suggest update to description" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Spirometry - Child" ; rdfs:subClassOf obo:NCIT_C85397 . obo:SCDO_1000354 obo:IAO_0000115 "Pattern of behavior which predisposes certain individuals to increased risk for contracting disease or sustaining personal injury. These behaviors may cluster into a risky lifestyle." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000354" ; oboInOwl:hasDbXref "MESH:D000073599" ; oboInOwl:hasExactSynonym "Health Risk Behaviors", "Risky Health Behavior", "Risky Health Behaviors" ; a owl:Class ; rdfs:label "Health Risk Behavior" ; rdfs:subClassOf obo:SCDO_0000487 . obo:SCDO_1000355 obo:IAO_0000115 "Physical surroundings or conditions of a hospital or other health facility and influence of these factors on patients and staff." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000355" ; oboInOwl:hasDbXref "MESH:D006272" ; a owl:Class ; rdfs:label "Health Facility Environment" ; rdfs:subClassOf obo:ExO_0000048 . obo:SCDO_1000356 obo:IAO_0000115 "Height above sea level or above the earth's surface." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000356" ; oboInOwl:hasDbXref "CSP:1035-6505" ; a owl:Class ; rdfs:label "Altitude" ; rdfs:subClassOf obo:SCDO_0000897 . obo:SCDO_1000357 obo:IAO_0000115 "A measure of educational progress reported using a questionnaire based approach, often used as a proxy for cognitive performance as the two are correlated." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Current Educational Attainment #11001" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000357" ; oboInOwl:hasDbXref "EFO:0004784" ; a owl:Class ; rdfs:label "Self Reported Educational Attainment" ; rdfs:subClassOf obo:SCDO_0000305 . obo:SCDO_1000360 obo:IAO_0000115 "A gene that encodes one of the globin family proteins, which are globular heme-containing proteins and include androglobin, cryoglobin, hemoglobin subunits, myoglobin and neuroglobin." ; obo:SCDO_0000303 "Suggest update to description in NCIT." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "NCIT:C142196" ; oboInOwl:hasExactSynonym "Globin Gene Family", "Globin Genes" ; a owl:Class ; rdfs:label "Globin Gene" ; rdfs:subClassOf obo:NCIT_C16612 . obo:SCDO_1000361 obo:IAO_0000115 "A gene that provides instructions for making a protein called alpha-globin." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Alpha-Globin Gene" ; rdfs:subClassOf obo:SCDO_1000360 . obo:SCDO_1000362 obo:IAO_0000115 "A gene located in the beta-globin locus (or gene cluster) on chromosome 11." ; obo:SCDO_0000303 """Include sub-classes?: HBE1 (encodes hemoglobin subunit epsilon) HBG1 HBG2 HBM HBQ1 HBZ""", """Should this perhaps rather be something like \"Beta-Globin Locus Gene\"? To prevent confusion with the HBB Gene. Request inclusion into relevant ontology.""" ; obo:SCDO_1000288 "Negligable" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Beta-Globin Gene" ; rdfs:subClassOf obo:SCDO_1000360 . obo:SCDO_1000363 obo:IAO_0000115 "A member of the alpha-globin family. In humans, it is encoded in the alpha-globin gene cluster or locus, located on chromosome 16. Two hemoglobin subunit zeta chains combine with two hemoglobin subunit epsilon chains to form the embryonic Hemoglobin Gower 1." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000363" ; oboInOwl:hasDbXref "MESH:D055543" ; oboInOwl:hasExactSynonym "HBAZ", "Haemoglobin Subunit Zeta", "Haemoglobin Zeta Chain", "Hemoglobin Zeta Chain", "Zeta Globin", "Zeta-Globin" ; a owl:Class ; rdfs:label "Hemoglobin Subunit Zeta" ; rdfs:subClassOf obo:SCDO_1000105 . obo:SCDO_1000364 obo:IAO_0000115 "An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia." ; obo:SCDO_0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000364" ; oboInOwl:hasDbXref "MESH:D006443" ; oboInOwl:hasExactSynonym "A2, Hemoglobin", "HbA2", "Normal Variant of Hemoglobin A", "alpha2delta2" ; a owl:Class ; rdfs:label "Hemoglobin A2" ; rdfs:subClassOf obo:SCDO_0006835 . obo:SCDO_1000366 obo:IAO_0000115 "A mutation that contributes to decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis." ; obo:SCDO_0000303 "Request inclusion into relevant ontology" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Delta Beta Thalassaemia Mutation" ; a owl:Class ; rdfs:label "Delta Beta Thalassemia Mutation" ; rdfs:subClassOf obo:SCDO_0009731 . obo:SCDO_1000371 obo:IAO_0000115 "A health abnormality in a woman during pregnancy." ; obo:SCDO_0000303 "Suggest update to description in HP. Currently no description." ; obo:SCDO_0000340 obo:HP_0002686 ; obo:SCDO_1000288 "Suggest update to description" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "HP:0002686" ; oboInOwl:hasExactSynonym "Maternal Health Problem" ; a owl:Class ; rdfs:label "Prenatal Maternal Abnormality" ; rdfs:subClassOf obo:HP_0001197 . obo:SCDO_1000376 obo:IAO_0000115 "In situ death of bone within the humeral head due to disruption of blood supply." ; obo:SCDO_0000303 "Request inclusion into NCIT as sub-class of \"Avascular Necrosis of Humerus\"." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Aseptic Necrosis of the Humeral Head", "Avascular Necrosis of the Humeral Head" ; a owl:Class ; rdfs:label "Osteonecrosis of the Humeral Head" ; rdfs:subClassOf obo:HP_0010885, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ] . obo:SCDO_1000379 obo:IAO_0000115 "Health care services that are respectful of and responsive to the health beliefs, practices and cultural and linguistic needs of diverse patients. The provider and the patient each bring their individual learned patterns of language and culture to the health care experience which must be transcended to achieve equal access and quality health care." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000379" ; oboInOwl:hasDbXref "MESH:D065246" ; oboInOwl:hasExactSynonym "Care, Culturally Congruent", "Culturally Congruent Care" ; a owl:Class ; rdfs:label "Culturally Competent Care" ; rdfs:subClassOf obo:SCDO_0000246 . obo:SCDO_1000383 obo:IAO_0000115 "Any kidney disorder occurring as a consequence of injury to the kidney." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Kidney Complication" ; a owl:Class ; rdfs:label "Renal Complication" ; rdfs:subClassOf obo:NCIT_C2959 . obo:SCDO_1000392 obo:IAO_0000115 "Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000392" ; oboInOwl:hasDbXref "MESH:D016329" ; oboInOwl:hasExactSynonym "Transcription Factor, Sp1" ; a owl:Class ; rdfs:label "Sp1 Transcription Factor" ; rdfs:subClassOf obo:NCIT_C26548 . obo:SCDO_1000394 obo:IAO_0000115 "A gene component is a component of a gene." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000394" ; oboInOwl:hasDbXref "SIO:010444" ; a owl:Class ; rdfs:label "Gene Component" ; rdfs:subClassOf obo:SCDO_0005722 . obo:SCDO_1000395 obo:IAO_0000115 "A gene regulatory component is a gene component that exerts a regulatory function." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000395" ; oboInOwl:hasDbXref "SIO:010085" ; a owl:Class ; rdfs:label "Gene Regulatory Component" ; rdfs:subClassOf obo:SCDO_1000394 . obo:SCDO_1000396 obo:IAO_0000115 "A gene enhancer is a short region of DNA that can be bound with proteins to enhance transcription levels of genes in a gene cluster." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000396" ; oboInOwl:hasDbXref "SIO:010086" ; a owl:Class ; rdfs:label "Gene Enhancer" ; rdfs:subClassOf obo:SCDO_1000395 . obo:SCDO_1000397 obo:IAO_0000115 "A gene promoter is a region of DNA that initiates transcription of a particular gene." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000397" ; oboInOwl:hasDbXref "SIO:010446" ; a owl:Class ; rdfs:label "Gene Promoter" ; rdfs:subClassOf obo:SCDO_1000395 . obo:SCDO_1000398 obo:SCDO_1000288 "None" ; dc:source , ; oboInOwl:hasExactSynonym "Erythroid Specific Enhancer of Bcl11A" ; a owl:Class ; rdfs:label "BCL11A Erythroid Enhancer" ; rdfs:subClassOf obo:SCDO_1000396 . obo:SCDO_1000401 obo:IAO_0000115 "A characteristic that further describes the nature of data." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Data Descriptor" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_1000402 obo:IAO_0000115 "The predominant publication type for articles and other items indexed for NLM databases." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000402" ; oboInOwl:hasDbXref "MESH:D016428" ; a owl:Class ; rdfs:label "Journal Article" ; rdfs:subClassOf obo:SCDO_0300003 . obo:SCDO_1000406 obo:IAO_0000115 "A characteristic or directive that further describes the nature of data sharing." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Data Sharing Descriptor" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_1000408 obo:IAO_0000115 "Requirements indicate additional conditions set for use of data." ; obo:SCDO_0000303 "Suggest update to description in DUO" ; obo:SCDO_0000340 obo:DUO_0000017 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "DUO:0000017" ; a owl:Class ; rdfs:label "Data Use Requirements" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_1000421 obo:IAO_0000115 "The standard method of providing feedback to study participants regarding their information (data, biological samples, genetic material) that has been shared." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Policy for Feedback to Participant", "Policy for Returning Results", "Policy for Returning Results to Participant" ; a owl:Class ; rdfs:label "Participant Feedback Policy" ; rdfs:subClassOf obo:SCDO_1000422, obo:SCDO_1000424 . obo:SCDO_1000422 obo:IAO_0000115 "An element or information entity that is required to be provided in consent forms." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Basic Element of a Consent Form" ; rdfs:subClassOf obo:SCDO_0007597 . obo:SCDO_1000423 obo:IAO_0000115 "The policy regarding participants' right to withdraw their participation in a study." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Participant Withdrawal Policy" ; rdfs:subClassOf obo:SCDO_1000422, obo:SCDO_1000424 . obo:SCDO_1000424 obo:IAO_0000115 "A course or principle of action adopted or proposed by a study." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Study Policy" ; rdfs:subClassOf obo:SCDO_0300005 . obo:SCDO_1000425 obo:IAO_0000115 "A statement of what the key investigational purpose of the study is." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Study Focus Statement" ; rdfs:subClassOf obo:SCDO_1000422 . obo:SCDO_1000426 obo:IAO_0000115 "A statement about how the researcher is obligated by law to report if the participant is found to have a communicable disease." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Communicable Disease - Report by Law Statement" ; rdfs:subClassOf obo:SCDO_1000422 . obo:SCDO_1000429 obo:IAO_0000115 "The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000429" ; oboInOwl:hasDbXref "MESH:D004992" ; a owl:Class ; rdfs:label "Medical Ethics" ; rdfs:subClassOf obo:SCDO_0006706 . obo:SCDO_1000430 obo:IAO_0000115 "Concepts related to ethics, excluding types of ethics." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Ethics Related Concept" ; rdfs:subClassOf obo:SCDO_0006339 . obo:SCDO_1000431 obo:IAO_0000115 "A protein expressed in enterocytes of the small intestine and released into the systemic circulation when there is intestinal damage. This protein plays a role in binding to saturated long-chain fatty acids with a high affinity and to unsaturated long-chain fatty acids with less affinity." ; obo:SCDO_0000303 "Suggest update to description in NCIT" ; obo:SCDO_0000340 , ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source ; oboInOwl:hasDbXref "NCIT:C29616" ; oboInOwl:hasExactSynonym "FABPI", "Fatty Acid-Binding Protein, Intestinal", "I-FABP", "Intestinal-Type Fatty Acid-Binding Protein", "iFABP" ; a owl:Class ; rdfs:label "Intestinal Fatty-Acid Binding Protein" ; rdfs:subClassOf obo:NCIT_C26548 . obo:SCDO_1000432 obo:IAO_0000115 "The level of intestinal fatty-acid binding protein in the systemic circulation (serum)." ; obo:SCDO_0000486 "Used to provide the evidence for intestinal injury due to VOC affecting the splanchnic vasculature." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Serum Intestinal Fatty-Acid Binding Protein Level" ; a owl:Class ; rdfs:comment "Measured in ng/ml" ; rdfs:label "Serum iFABP Level" ; rdfs:subClassOf obo:CMO_0000023 . obo:SCDO_1000433 obo:IAO_0000115 "Damage inflicted on the intestine." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Intestinal Damage" ; a owl:Class ; rdfs:label "Intestinal Injury" ; rdfs:subClassOf obo:HP_0025031, obo:NCIT_C3671 . obo:SCDO_1000436 obo:IAO_0000115 "Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (reperfusion), including swelling; hemorrhage; necrosis; and damage from free radicals. The most common instance is myocardial reperfusion injury." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000436" ; dc:source ; oboInOwl:hasDbXref "EFO:0002687" ; oboInOwl:hasExactSynonym "Hypoxia-Reoxygenation Injury", "Hypoxia/Reperfusion Injury", "IRI", "Ischaemia Reperfusion Injury", "Ischemia Reperfusion Injury", "Reoxygenation Injury" ; a owl:Class ; rdfs:label "Hypoxia-Reperfusion Injury" ; rdfs:subClassOf obo:NCIT_C3671 . obo:SCDO_1000439 obo:IAO_0000115 "An increased circulating blood concentration of the intestinal fatty-acid binding protein." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:comment "Significantly high serum iFABP levels is evidence of intestinal injury." ; rdfs:label "Elevated Serum iFABP Level" ; rdfs:subClassOf obo:HP_0010876 . obo:SCDO_1000444 obo:IAO_0000115 "The level of L-selectin in the systemic circulation (serum)." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Serum CD62L Level", "Soluble CD62L" ; a owl:Class ; rdfs:label "Serum L-Selectin Level" ; rdfs:subClassOf obo:CMO_0000023 . obo:SCDO_1000445 obo:IAO_0000115 "The number of aged neutrophils in a specified volume of blood, usually 1 cubic millimeter." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; oboInOwl:hasExactSynonym "Activated Neutrophil Count" ; a owl:Class ; rdfs:label "Aged Neutrophil Count" ; rdfs:subClassOf obo:CMO_0000030 . obo:SCDO_1000448 obo:IAO_0000115 "A medication that is typically used for indications other than pain control but provides control of pain in some painful diseases." ; obo:SCDO_1000288 "None" ; dc:source ; oboInOwl:hasExactSynonym "Adjuvant Analgesic Agent" ; a owl:Class ; rdfs:label "Adjunct Analgesic Agent" ; rdfs:subClassOf obo:SCDO_0001133 . obo:SCDO_1000449 obo:IAO_0000115 "An infusion of ketamine at a low dose (up to 5 µg/kg/min)." ; obo:SCDO_1000288 "None" ; dc:source ; a owl:Class ; rdfs:comment "Low-dose ketamine infusion may be considered as an adjunct analgesic agent in patients with vaso-occlusive episodes who report continued severe pain despite high-dose opioid therapy, particularly those experiencing opioid-induced adverse effects." ; rdfs:label "Low-Dose Ketamine Infusion" ; rdfs:subClassOf obo:SCDO_1000448 . obo:SCDO_1000452 obo:IAO_0000115 "Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during neoplasm growth, tissue invasion, and metastasis." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000452" ; oboInOwl:hasDbXref "MESH:D000072716" ; oboInOwl:hasExactSynonym "Cancer-Related Pain", "Pains, Neoplasm-Related" ; a owl:Class ; rdfs:label "Cancer Pain" ; rdfs:subClassOf obo:SCDO_0000851 . obo:SCDO_1000455 obo:IAO_0000115 "The current age of a patient, calculated using the current date and the patient's date of birth and provided in years." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Calculated Current Age in Years" ; a owl:Class ; rdfs:label "Calculated Current Age (Years)" ; rdfs:subClassOf obo:SCDO_1000527 . obo:SCDO_1000457 obo:IAO_0000115 "A type of consent that includes an aspect of timing (i.e. an indication of when consent was acquired)." ; obo:SCDO_0000303 "Request inclusion into ICO below \"Informed Consent\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Temporal Consent Concept" ; rdfs:subClassOf obo:NCIT_C25460 . obo:SCDO_1000458 obo:IAO_0000115 "Consent given prior to enrollment." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Prospective Consent" ; rdfs:subClassOf obo:SCDO_1000457 . obo:SCDO_1000459 obo:IAO_0000115 "Consent that is taken later after enrollment into study especially in emergency situations." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Victoria Nembaware)" ; a owl:Class ; rdfs:label "Deferred Consent" ; rdfs:subClassOf obo:SCDO_1000457 . obo:SCDO_1000460 obo:IAO_0000115 "Informed consent given prior to enrollment." ; obo:SCDO_0000303 "Request inclusion into ICO below \"Informed Consent\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Victoria Nembaware)" ; a owl:Class ; rdfs:label "Prospective Informed Consent" ; rdfs:subClassOf obo:SCDO_0007087, obo:SCDO_1000458 . obo:SCDO_1000461 obo:IAO_0000115 "Consent obtained at a population level through public/community engagement where individual consenting is not feasible. This is normally done for low risk studies and/or in case of emergencies." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Victoria Nembaware)" ; a owl:Class ; rdfs:label "Waived Consent" ; rdfs:subClassOf obo:NCIT_C25460 . obo:SCDO_1000462 obo:IAO_0000115 "A decision made by a research ethics committee." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Research Ethics Committee Decision" ; rdfs:subClassOf obo:SCDO_1000430 . obo:SCDO_1000463 obo:IAO_0000115 "When a research ethics committee approves a study's application for approval of their proposed research." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Approval of Ethics" ; rdfs:subClassOf obo:SCDO_1000462 . obo:SCDO_1000464 obo:IAO_0000115 "When a research ethics committee declines a study's application for approval of their proposed research." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Disapproval of Ethics" ; rdfs:subClassOf obo:SCDO_1000462 . obo:SCDO_1000465 obo:IAO_0000115 "A method in which a patient or their legal representative provides consent." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Mode of Providing Consent" ; rdfs:subClassOf obo:SCDO_0007597 . obo:SCDO_1000466 obo:IAO_0000115 "When the participant or a legal representative or family member provides consent by filling out and/or signing a written form." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Written Consent" ; rdfs:subClassOf obo:SCDO_1000465 . obo:SCDO_1000467 obo:IAO_0000115 "When the participant communicates consent orally rather than by filling out and signing a written form. Normally a witness is present when verbal consent is given." ; obo:SCDO_0000303 "Request inclusion into the Informed Consent Ontology." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO" ; a owl:Class ; rdfs:label "Verbal Consent" ; rdfs:subClassOf obo:SCDO_1000465 . obo:SCDO_1000470 obo:IAO_0000115 "A unique identifier assigned to a study participant's data when it is registered in the SickleInAfrica data registry." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica Participant Number" ; rdfs:subClassOf obo:NCIT_C69256 . obo:SCDO_1000471 obo:IAO_0000115 "The name of the country where the sample or data was collected." ; obo:SCDO_0000340 obo:FLU_0000831 ; obo:SCDO_1000288 "Few but definitions not specific enough" ; oboInOwl:hasDbXref "FLU:0000831" ; a owl:Class ; rdfs:label "Country of Data Collection" ; rdfs:subClassOf obo:SCDO_1000401 . obo:SCDO_1000472 obo:IAO_0000115 "The rules by which data are described and recorded." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Data Standards" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_1000474 obo:IAO_0000115 "A data element used to capture or facilitate the capture of data in a clinical or research assessment." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Clinical or Research Assessment Data Element" ; rdfs:subClassOf obo:SCDO_1000472 . obo:SCDO_1000475 obo:IAO_0000115 "A type of question pertaining to a clinical or research assessment data element." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Clinical or Research Assessment Question Type" ; rdfs:subClassOf obo:SCDO_1000472 . obo:SCDO_1000477 a owl:Class ; rdfs:label "deprecated Field Type" ; rdfs:subClassOf obo:SCDO_0000359 ; owl:deprecated true . obo:SCDO_1000479 a owl:Class ; rdfs:label "deprecated Calculation Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000480 a owl:Class ; rdfs:label "deprecated Checkbox Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000481 a owl:Class ; rdfs:label "deprecated Descriptive Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000482 a owl:Class ; rdfs:label "deprecated Dropdown Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000483 a owl:Class ; rdfs:label "deprecated Dropdown Multiple Choice Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000484 a owl:Class ; rdfs:label "deprecated Dropdown Single Choice Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000485 a owl:Class ; rdfs:label "deprecated File Upload Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000486 a owl:Class ; rdfs:label "deprecated Radio Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000487 a owl:Class ; rdfs:label "deprecated Text Box Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000488 a owl:Class ; rdfs:label "deprecated Notes Box Field Type" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000489 a owl:Class ; rdfs:label "deprecated Slider - Visual Analog Scale" ; rdfs:subClassOf obo:SCDO_1000477 ; owl:deprecated true . obo:SCDO_1000490 obo:IAO_0000115 "The situation, with regard to obtaining consent from a respondent, at a particular stage during a process." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Consent Status" ; rdfs:subClassOf obo:SCDO_0007597 . obo:SCDO_1000492 obo:IAO_0000115 "A question that provides the respondent with specific answer options to choose from." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Close-Ended Question" ; rdfs:subClassOf obo:SCDO_1000475 . obo:SCDO_1000493 obo:IAO_0000115 "A question that allows the respondent to give their own answer instead of selecting an answer from answer options." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Open-Ended Question" ; rdfs:subClassOf obo:SCDO_1000475 . obo:SCDO_1000494 obo:IAO_0000115 "A close-ended question that provides two possible answers." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Dichotomous Question" ; rdfs:subClassOf obo:SCDO_1000492 . obo:SCDO_1000495 obo:IAO_0000115 "A close-ended question that provides multiple answers for respondents to select from and allows for the selection of multiple options." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Multiple Choice Multiple Selection Question" ; rdfs:subClassOf obo:SCDO_1000492 . obo:SCDO_1000496 obo:IAO_0000115 "A close-ended question that provides multiple answers for respondents to select from but allows for the selection of only one option." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Multiple Choice Single Selection Question" ; rdfs:subClassOf obo:SCDO_1000492 . obo:SCDO_1000497 obo:IAO_0000115 "A dichotomous question that has answer options \"true\" and \"false\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "True-False Question" ; rdfs:subClassOf obo:SCDO_1000494 . obo:SCDO_1000498 obo:IAO_0000115 "A dichotomous question that has answer options \"yes\" and \"no\"." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Yes-No Question" ; rdfs:subClassOf obo:SCDO_1000494 . obo:SCDO_1000501 obo:IAO_0000115 "A open ended question that restricts the nature of the text answer that can be provided by the respondent." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Open-Ended Question - Restricted" ; rdfs:subClassOf obo:SCDO_1000493 . obo:SCDO_1000502 obo:IAO_0000115 "A open ended question that allows the respondent to respond in free text, without any restrictions on the nature of the text answer provided." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Open-Ended Question - Free Text" ; rdfs:subClassOf obo:SCDO_1000493 . obo:SCDO_1000508 obo:IAO_0000115 "A data element in a SickleInAfrica data capture instrument." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "SickleInAfrica DE" ; a owl:Class ; rdfs:label "SickleInAfrica Data Element" ; rdfs:subClassOf obo:SCDO_1000474 . obo:SCDO_1000509 obo:IAO_0000115 "A data element in the SickleInAfrica core data capture instrument." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "SickleInAfrica Core DE" ; a owl:Class ; rdfs:label "SickleInAfrica Core Data Element" ; rdfs:subClassOf obo:SCDO_1000508 . obo:SCDO_1000510 obo:IAO_0000115 "The Sickle in Africa core data element that collects the concentration of albumin in the respondent's urine." ; obo:SCDO_1000518 "Urinary albumin concentration" ; obo:SCDO_1000519 "urinary_microalbumin_conc" ; obo:SCDO_1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" ; obo:SCDO_1000737 "µg/mL; PX141501" ; obo:SCDO_1000739 3 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Urinary Albumin Concentration Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0001209 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C64572 ] . obo:SCDO_1000512 obo:IAO_0000115 "The Sickle in Africa core data element that records whether the respondent has consented as necessary." ; obo:SCDO_1000517 """1, Yes 2, No -7, Refused -9, Don't Know""" ; obo:SCDO_1000518 "Has the patient consented?" ; obo:SCDO_1000519 "consent_obtained" ; obo:SCDO_1000735 "Consent" ; obo:SCDO_1000739 1 ; obo:SCDO_1000749 "radio" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Informed Consent Obtained Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000025 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000027 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000513 ] . obo:SCDO_1000513 obo:IAO_0000115 "An indication of whether informed consent was obtained from the respondent and/or their proxy." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Informed Consent Obtained" ; rdfs:subClassOf obo:SCDO_1000490 . obo:SCDO_1000514 obo:IAO_0000115 "Voluntary authorization given by a respondent and/or their proxy to be enrolled into a study as a research subject." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps the ICO." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Study Enrollment Consent" ; rdfs:subClassOf obo:SCDO_0007087 . obo:SCDO_1000515 obo:IAO_0000115 "Voluntary authorization given by a study respondent and/or their proxy to have their specimen(s) stored." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps the ICO." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Specimen Storage Consent" ; rdfs:subClassOf obo:SCDO_0007087 . obo:SCDO_1000516 obo:IAO_0000115 "Voluntary authorization given by a study paticipant to have their genetic material stored." ; obo:SCDO_0000303 "Request inclusion into relevant ontology, perhaps the ICO." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Genetic Material Storage Consent" ; rdfs:subClassOf obo:SCDO_0007087 . obo:SCDO_1000517 obo:IAO_0000115 "Records the answer options text for input in Redcap for a data element that provides answer options." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has answer options text" . obo:SCDO_1000518 obo:IAO_0000115 "Records the field label of a data element." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has field label" . obo:SCDO_1000519 obo:IAO_0000115 "Records the variable of the associated data element from a REDCap data capture instrument." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has redcap variable" . obo:SCDO_1000520 obo:IAO_0000115 "The Sickle in Africa core data element that records the type(s) of informed consent obtained from the participant." ; obo:SCDO_1000517 """1, Study Enrollment Consent 2, Specimen Storage Consent 3, Genetic Material Storage Consent 4, Broad Consent""" ; obo:SCDO_1000518 "Type(s) of informed consent obtained" ; obo:SCDO_1000519 "consent_type" ; obo:SCDO_1000735 "Consent" ; obo:SCDO_1000739 2 ; obo:SCDO_1000749 "checkbox" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Type of Informed Consent Obtained Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000495 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:ICO_0000179 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000515 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000516 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000521 ], [ a owl:Restriction ; owl:hasValue 0 ; owl:onProperty obo:SCDO_1000529 ], [ a owl:Restriction ; owl:hasValue 4 ; owl:onProperty obo:SCDO_1000530 ] . obo:SCDO_1000521 obo:IAO_0000115 "An indication of the type of informed consent that was obtained from the respondent and/or their proxies." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Type of Informed Consent Obtained" ; rdfs:subClassOf obo:SCDO_1000490 . obo:SCDO_1000522 obo:IAO_0000115 "Time-related information that can be observed and is related to consent." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Temporal Observable of Consent" ; rdfs:subClassOf obo:SCDO_0007597, obo:SCDO_1000537 . obo:SCDO_1000523 obo:IAO_0000115 "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25555 ; oboInOwl:hasExactSynonym "has lower limit of normal", "has lower reference limit" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has LLN" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000524 obo:IAO_0000115 "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25706 ; oboInOwl:hasExactSynonym "has upper limit of normal", "has upper reference limit" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has ULN" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000525 obo:IAO_0000115 "A relationship between a Clinical or Research Assessment Data Element and a Clinical or Research Assessment Question Type." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "is question type" ; rdfs:range obo:SCDO_1000475 . obo:SCDO_1000526 obo:IAO_0000115 "A relationship between a multiple choice data element and an answer option or a group of answer options that are provided to the respondent by the data element." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has answer option" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000527 obo:IAO_0000115 "The current age of a patient, calculated using the current date and the patient's date of birth." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Calculated Current Age" ; rdfs:subClassOf obo:SCDO_0000304 . obo:SCDO_1000528 obo:IAO_0000115 "A relationship between a data element and the type of information that is collected by that data element." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "collects" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000529 obo:IAO_0000115 "Records the minimum number of selections that a respondent is allowed to make from a list of multiple answer options provided for a data element." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:label "min number of selections allowed" ; rdfs:range xsd:nonNegativeInteger . obo:SCDO_1000530 obo:IAO_0000115 "Records the maximum number of selections that a respondent is allowed to make from a list of multiple answer options provided for a data element." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:label "max number of selections allowed" ; rdfs:range xsd:nonNegativeInteger . obo:SCDO_1000532 obo:IAO_0000115 "The Sickle in Africa core data element that records the date on which the respondent signed the consent form for the relevant study." ; obo:SCDO_1000518 "Date subject signed consent (dd/mm/yyyy)" ; obo:SCDO_1000519 "consent_date" ; obo:SCDO_1000735 "Consent" ; obo:SCDO_1000739 3 ; obo:SCDO_1000741 "date_dmy" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Date of Signing Consent Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:ICO_0000036 ] . obo:SCDO_1000533 obo:IAO_0000115 "The Sickle in Africa core data element that records the name of the person who managed the process of consenting the respondent." ; obo:SCDO_1000518 "Consented by:" ; obo:SCDO_1000519 "consented_by" ; obo:SCDO_1000735 "Consent" ; obo:SCDO_1000739 4 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Consented By Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000536 ] . obo:SCDO_1000534 obo:IAO_0000115 "An indication of whether the respondent has had a blood transfusion since their last hospital visit. This is any transfusion before enrolment if it is the patient's first hospital visit." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Blood Transfusion Since Last Visit" ; rdfs:subClassOf obo:SCDO_1000318 . obo:SCDO_1000535 obo:IAO_0000115 "An indication of whether the consent form used for obtaining informed consent from the respondent has been uploaded to the relevant electronic system." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Consent Form Uploaded" ; rdfs:subClassOf obo:SCDO_1000490 . obo:SCDO_1000536 obo:IAO_0000115 "The name of the person who conducted consenting of the respondent." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Consented By" ; rdfs:subClassOf obo:SCDO_0007597 . obo:SCDO_1000537 obo:IAO_0000115 "Time-related information that can be observed." ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Temporal Observable" ; rdfs:subClassOf obo:SCDO_0001000 . obo:SCDO_1000538 obo:IAO_0000115 "Time-related information that can be observed and is related to a diagnosis." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Diagnosis Temporal Observable" ; rdfs:subClassOf obo:SCDO_1000537, obo:SCDO_1000553 . obo:SCDO_1000539 obo:IAO_0000115 "The Sickle in Africa core data element that records the visit date, in the format dd/mm/yyyy." ; obo:SCDO_1000518 "Visit date (dd/mm/yyyy)" ; obo:SCDO_1000519 "date_today" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "date_dmy" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Visit Date Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C83031 ] . obo:SCDO_1000542 obo:IAO_0000115 "The Sickle in Africa core data element that records the site-specific unique identifier that was assigned to the study participant by the data collectors at the data collection site." ; obo:SCDO_1000518 "Site participant number" ; obo:SCDO_1000519 "participant_number" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000737 "Site-specific ID eg. GH20181234 for Ghana, NG20184321 for Nigeria or TZ20180001 for Tanzania" ; obo:SCDO_1000739 3 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Site Participant Number Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000730 ] . obo:SCDO_1000543 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's date of birth in the format dd/mm/yyyy." ; obo:SCDO_1000518 "Date of birth (dd/mm/yyyy)" ; obo:SCDO_1000519 "date_of_birth" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 9 ; obo:SCDO_1000741 "date_dmy" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Date of Birth Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C68615 ] . obo:SCDO_1000545 obo:IAO_0000115 "The current age of a patient, calculated using the current date and the patient's date of birth and provided in months." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Calculated Current Age in Months" ; a owl:Class ; rdfs:label "Calculated Current Age (Months)" ; rdfs:subClassOf obo:SCDO_1000527 . obo:SCDO_1000546 obo:IAO_0000115 "The length of time that a person has lived since their birth up until the current day, as reported in years by the respondent." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Self-Reported Age in Years", "Self-Reported Current Age in Years" ; a owl:Class ; rdfs:label "Self-Reported Current Age (Years)" ; rdfs:subClassOf obo:SCDO_0000304 . obo:SCDO_1000547 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's age, as reported by the respondent in years." ; obo:SCDO_1000518 "Self-reported age (in years)" ; obo:SCDO_1000519 "age_on_day_of_visit" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000737 "Age on day of visit" ; obo:SCDO_1000739 11 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000743 0 ; obo:SCDO_1000744 125 ; obo:SCDO_1000748 "RH" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Self-Reported Age Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000546 ] . obo:SCDO_1000548 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's current marital status." ; obo:SCDO_1000517 """1, Married 2, Widowed 3, Divorced 4, Separated 5, Never been married/Annulled""" ; obo:SCDO_1000518 "Current marital status" ; obo:SCDO_1000519 "marital_status" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 15 ; obo:SCDO_1000749 "radio" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Current Marital Status Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C156541 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C51773 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C51774 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C51775 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C51776 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000307 ] . obo:SCDO_1000549 obo:IAO_0000115 "The Sickle in Africa core data element that records the date on which the respondent last received a blood transfusion." ; obo:SCDO_1000518 "Date of blood transfusion" ; obo:SCDO_1000519 "transfusion_date" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 8 ; obo:SCDO_1000741 "date_dmy" ; obo:SCDO_1000742 "[blood_transfusion] = \"Yes\"" ; obo:SCDO_1000749 "text" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Date of Transfusion Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000566 ] . obo:SCDO_1000550 obo:IAO_0000115 "The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent, in the case where the type of test was not listed as an answer option in a previous data element." ; obo:SCDO_1000518 "If other test, please specify:" ; obo:SCDO_1000519 "other_test" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000739 6 ; obo:SCDO_1000742 "[type_of_test] = '6'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - SCD Other Test Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000577 ] . obo:SCDO_1000551 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's sex." ; obo:SCDO_1000517 """1, Male 2, Female 3, Intersex -7, Refused""" ; obo:SCDO_1000518 "Respondent's sex" ; obo:SCDO_1000519 "respondent_sex" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 14 ; obo:SCDO_1000749 "radio" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Sex Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:GSSO_000109 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C16576 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C20197 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000027 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C28421 ] . obo:SCDO_1000552 obo:IAO_0000115 "The Sickle in Africa core data element that records whether the respondent knows the date of their SCD diagnosis." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Is date of SCD diagnosis known?" ; obo:SCDO_1000519 "diagnosis_date_known" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000739 1 ; obo:SCDO_1000749 "yesno" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Date of Diagnosis Known Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000555 ] . obo:SCDO_1000553 obo:IAO_0000115 "Information or a description that further describes a diagnosis." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Diagnosis Descriptor" ; rdfs:subClassOf obo:SCDO_0000379 . obo:SCDO_1000554 obo:IAO_0000115 "An indication of whether the date of the respondent's diagnosis of a disease is known by the respondent or the respondent's guardian." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Date of Diagnosis Known" ; rdfs:subClassOf obo:SCDO_1000538 . obo:SCDO_1000555 obo:IAO_0000115 "An indication of whether the date of the respondent's SCD diagnosis is known by the respondent or the respondent's guardian." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Date of SCD Diagnosis Known" ; rdfs:subClassOf obo:SCDO_1000554 . obo:SCDO_1000556 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's date of diagnosis in the format dd/mm/yyyy." ; obo:SCDO_1000518 "Date of SCD diagnosis (dd/mm/yyyy)" ; obo:SCDO_1000519 "exact_diagnosis_date" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000739 2 ; obo:SCDO_1000741 "date_dmy" ; obo:SCDO_1000742 "[diagnosis_date_known] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Date of Diagnosis Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000558 ] . obo:SCDO_1000558 obo:IAO_0000115 "The date on which a diagnosis of sickle cell disease was made." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Date of SCD Diagnosis" ; rdfs:subClassOf obo:NCIT_C164339 . obo:SCDO_1000566 obo:IAO_0000115 "The date on which a patient received a blood transfusion." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Date of Blood Transfusion" ; rdfs:subClassOf obo:SCDO_1000537, obo:SCDO_1000590 . obo:SCDO_1000568 obo:IAO_0000115 "The year in which a sickle cell disease diagnosis was made." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Year of SCD Diagnosis" ; rdfs:subClassOf obo:NCIT_C168823 . obo:SCDO_1000569 obo:IAO_0000115 "The month when a diagnosis was assigned to an individual's condition." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Month of Diagnosis" ; rdfs:subClassOf obo:SCDO_1000538 . obo:SCDO_1000570 obo:IAO_0000115 "The month when a sickle cell disease diagnosis was made." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Month of SCD Diagnosis" ; rdfs:subClassOf obo:SCDO_1000569 . obo:SCDO_1000571 obo:IAO_0000115 "The Sickle in Africa core data element that records the month of the year in which the respondent was diagnosed with SCD." ; obo:SCDO_1000517 """-9, Don't know 1, 1 2, 2 3, 3 4, 4 5, 5 6, 6 7, 7 8, 8 9, 9 10, 10 11, 11 12, 12""" ; obo:SCDO_1000518 "Month of SCD diagnosis" ; obo:SCDO_1000519 "month_of_diagnosis" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000739 4 ; obo:SCDO_1000742 "[diagnosis_date_known] = '0'" ; obo:SCDO_1000749 "dropdown" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Month of Diagnosis Question" ; rdfs:subClassOf obo:SCDO_1000509 . obo:SCDO_1000572 obo:IAO_0000115 "A diagnosis is the result of a medical investigation to identify a disorder from its signs and symptoms." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000572" ; oboInOwl:hasDbXref "SIO:001331" ; a owl:Class ; rdfs:label "Diagnosis" ; rdfs:subClassOf obo:NCIT_C18772 . obo:SCDO_1000573 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's SCD test result." ; obo:SCDO_1000517 """1, SS 2, SBThal 3, SC 4, AS 5, Other""" ; obo:SCDO_1000518 "SCD test result" ; obo:SCDO_1000519 "scd_test_result" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000737 "SS = Sickle Cell Disease-SS | SBThal = Sickle Beta Thalassemia | SC = Sickle Cell Disease-SC | AS = Sickle Cell Trait" ; obo:SCDO_1000739 3 ; obo:SCDO_1000748 "RH" ; obo:SCDO_1000749 "dropdown" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - SCD Test Result Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000028 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0001055 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0001059 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000574 ] . obo:SCDO_1000574 obo:IAO_0000115 "The result of a medical investigation to identify the type of sickle cell disease that a person has." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SCD Test Result" ; rdfs:subClassOf obo:CMO_0000508, obo:SCDO_1000572 . obo:SCDO_1000575 obo:IAO_0000115 "The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent." ; obo:SCDO_1000517 """1, HPLC 2, HBE 3, IEF 4, Basique 5, Acide 6, Sickle SCAN rapid test 7, Other""" ; obo:SCDO_1000518 "Type of test?" ; obo:SCDO_1000519 "type_of_test" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000737 "HPLC = High-Performance Liquid Chromatography| HBE = Hemoglobin Electrophoresis | IEF = Isoelectric Focusing| Basique = Basique SCD Test | Acide = Acide SCD Test" ; obo:SCDO_1000739 5 ; obo:SCDO_1000749 "dropdown" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Type of SCD Test Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:CHMO_0001009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000028 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0000666 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000669 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000768 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000769 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000577 ] . obo:SCDO_1000576 obo:IAO_0000115 "A piece of information that further describes a diagnostic measurement." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Diagnostic Measurement Descriptor" ; rdfs:subClassOf obo:SCDO_0000379 . obo:SCDO_1000577 obo:IAO_0000115 "The type of test that was used to obtain a sickle cell disease diagnosis." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Type of SCD Test" ; rdfs:subClassOf obo:SCDO_1000576 . obo:SCDO_1000578 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's SCD test result, in the case where the specific result was not listed as an answer option in a previous data element." ; obo:SCDO_1000518 "If other SCD test result, please specify:" ; obo:SCDO_1000519 "other_scd_test_result" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000739 4 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - SCD Test Other Result Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000574 ] . obo:SCDO_1000579 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's ABO Blood Group." ; obo:SCDO_1000517 """1, A+ 2, A- 3, B+ 4, B- 5, O+ 6, O- 7, AB+ 8, AB-""" ; obo:SCDO_1000518 "ABO blood group" ; obo:SCDO_1000519 "abo_blood_group" ; obo:SCDO_1000735 "SCD Diagnosis Details" ; obo:SCDO_1000739 7 ; obo:SCDO_1000749 "dropdown" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Blood Group Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000582 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000583 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000585 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000586 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000587 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000588 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000589 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:HP_0032224 ] . obo:SCDO_1000580 obo:IAO_0000115 "A blood test that uses the principles of gel electrophoresis to separate out the various types of hemoglobin in order to determine the level of different types of hemoglobin in the blood." ; obo:SCDO_0000303 "Placed as sub-class here according to position in the \"Read Codes, Clinical Terms Version 3 (CTV3)\" Ontology" ; obo:SCDO_1000288 "Few but definitions not available" ; dc:source , ; oboInOwl:hasExactSynonym "Electrophoresis - hemoglobin", "HBE", "Haemoglobin Electrophoresis", "Hb electrophoresis", "Hemoglobinopathy - electrophoresis", "Hgb electrophoresis", "Sickle cell - electrophoresis", "Thalassemia Screening", "Thallasemia - electrophoresis" ; a owl:Class ; rdfs:label "Hemoglobin Electrophoresis" ; rdfs:subClassOf obo:SCDO_0000424, obo:SCDO_0000522, obo:SCDO_1000577 . obo:SCDO_1000582 obo:IAO_0000115 "A blood type containing type A red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Kambe Banda)" ; oboInOwl:hasExactSynonym "A+", "Blood group A Rh(D) positive", "Type A blood, Rh positive" ; a owl:Class ; rdfs:label "Blood Type A Positive" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000583 obo:IAO_0000115 "A blood type containing type A red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor.", "SCDO (Kambe Banda)" ; obo:SCDO_1000288 "Few but definitions not available" ; oboInOwl:hasExactSynonym "A-", "Blood group A Rh(D) negative", "Type A blood, Rh negative" ; a owl:Class ; rdfs:label "Blood Type A Negative" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000584 obo:IAO_0000115 "A blood type containing type B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Kambe Banda)" ; oboInOwl:hasExactSynonym "B+", "Blood group B Rh(D) positive", "Type B blood, Rh positive" ; a owl:Class ; rdfs:label "Blood Type B Positive" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000585 obo:IAO_0000115 "A blood type containing type B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Kambe Banda)" ; oboInOwl:hasExactSynonym "B-", "Blood group B Rh(D) negative", "Type B blood, Rh negative" ; a owl:Class ; rdfs:label "Blood Type B Negative" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000586 obo:IAO_0000115 "A blood type containing no surface markers on red blood cells, with the presence of a protein called rhesus (Rh) factor." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Kambe Banda)" ; oboInOwl:hasExactSynonym "Blood group O Rh(D) positive", "O+", "Type O blood, Rh positive" ; a owl:Class ; rdfs:label "Blood Type O Positive" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000587 obo:IAO_0000115 "A blood type containing no surface markers on red blood cells, with the absence of a protein called rhesus (Rh) factor." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Kambe Banda)" ; oboInOwl:hasExactSynonym "Blood group O Rh(D) negative", "O-", "Type O blood, Rh negative" ; a owl:Class ; rdfs:label "Blood Type O Negative" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000588 obo:IAO_0000115 "A blood type containing both type A and B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Kambe Banda)" ; oboInOwl:hasExactSynonym "AB+", "Blood group AB Rh(D) positive", "Type AB blood, Rh positive" ; a owl:Class ; rdfs:label "Blood Type AB Positive" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000589 obo:IAO_0000115 "A blood type containing both type A and B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor" ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Kambe Banda)" ; oboInOwl:hasExactSynonym "AB-", "Blood group AB Rh(D) negative", "Type AB blood, Rh negative" ; a owl:Class ; rdfs:label "Blood Type AB Negative" ; rdfs:subClassOf obo:HP_0032224 . obo:SCDO_1000590 obo:IAO_0000115 "Information about how a patient's SCD is being managed." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SCD Management Details" ; rdfs:subClassOf obo:NCIT_C19332, obo:SCDO_0001152 . obo:SCDO_1000591 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's hydroxyurea use status (i.e. an indication of whether the respondent is using hydroxyurea)." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Using hydroxyurea" ; obo:SCDO_1000519 "using_hydroxyurea" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 1 ; obo:SCDO_1000748 "RH" ; obo:SCDO_1000749 "yesno" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hydroxyurea Use Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000592 ] . obo:SCDO_1000592 obo:IAO_0000115 "An indication of whether the respondent is using hydroxyurea." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hydroxyurea Use Status" ; rdfs:subClassOf obo:SCDO_1000318, obo:SCDO_1000590 . obo:SCDO_1000593 obo:IAO_0000115 "The Sickle in Africa core data element that records the date on which the respondent started hydroxyurea therapy, in the format dd/mm/yyyy." ; obo:SCDO_1000518 "Date of initiation of hydroxyurea therapy (dd/mm/yyyy)" ; obo:SCDO_1000519 "date_of_initiation_of_hydr" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 2 ; obo:SCDO_1000741 "date_dmy" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hydroxyurea Initiation Date Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000594 ] . obo:SCDO_1000594 obo:IAO_0000115 "The date on which hydroxyurea therapy was initiated." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Date of Hydroxyurea Therapy Initiation" ; rdfs:subClassOf obo:SCDO_1000537 . obo:SCDO_1000595 obo:IAO_0000115 "The Sickle in Africa core data element that records whether the respondent is using penicillin V as a prophylaxis against bacterial infections." ; obo:SCDO_1000517 """1, Yes 2, No -6, NA""" ; obo:SCDO_1000518 "Using penicillin V (prophylaxis)" ; obo:SCDO_1000519 "penicillin_v_prophylaxis" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 3 ; obo:SCDO_1000748 "RH" ; obo:SCDO_1000749 "radio" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Penicillin V Use Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C48660 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000596 ] . obo:SCDO_1000596 obo:IAO_0000115 "An indication of whether the respondent is using penicillin V prophylaxis." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Penicillin V Prophylaxis Use Status" ; rdfs:subClassOf obo:SCDO_1000318, obo:SCDO_1000590 . obo:SCDO_1000597 obo:IAO_0000115 "The Sickle in Africa core data element that records the respondent's folic acid use status (i.e. an indication of whether the respondent is using folic acid)." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Using folic acid" ; obo:SCDO_1000519 "folic_acid" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 5 ; obo:SCDO_1000748 "RH" ; obo:SCDO_1000749 "yesno" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Folic Acid Use Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000598 ] . obo:SCDO_1000598 obo:IAO_0000115 "An indication of whether the respondent is using folic acid." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Folic Acid Use Status" ; rdfs:subClassOf obo:SCDO_1000318, obo:SCDO_1000590 . obo:SCDO_1000599 obo:IAO_0000115 "An indication of whether the respondent is using malaria prophylaxis." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Malaria Prophylaxis Status" ; rdfs:subClassOf obo:SCDO_1000318, obo:SCDO_1000590 . obo:SCDO_1000600 obo:IAO_0000115 "The Sickle in Africa core data element that records whether the respondent is using malaria chemoprophylaxis (drugs that prevent malaria)." ; obo:SCDO_1000517 """1, Yes 2, No -6, NA""" ; obo:SCDO_1000518 "Using malaria chemoprophylaxis" ; obo:SCDO_1000519 "antimalaria_prophylaxis" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 4 ; obo:SCDO_1000749 "radio" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Malaria Prophylaxis Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:NCIT_C48660 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000599 ] . obo:SCDO_1000601 obo:IAO_0000115 "The Sickle in Africa core data element that records whether the respondent's pneumococcal vaccination is up to date." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Pneumococcal vaccination up to date" ; obo:SCDO_1000519 "pneumococcal_vacc_uptodate" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 6 ; obo:SCDO_1000748 "RH" ; obo:SCDO_1000749 "yesno" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Pneumococcal Vaccination Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000602 ] . obo:SCDO_1000602 obo:IAO_0000115 "An indication of whether the respondent is up to date with their pneumococcal vaccinations." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Pneumococcal Vaccination Status" ; rdfs:subClassOf obo:SCDO_1000590 . obo:SCDO_1000604 obo:IAO_0000115 "The person who recorded the information about how a patient's condition is being managed." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Management Details Added By" ; rdfs:subClassOf obo:SCDO_1000590 . obo:SCDO_1000605 obo:IAO_0000115 "Any assay which measures the amount, level or concentration of urea in whole blood." ; obo:SCDO_0000340 obo:MMO_0000272 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000605" ; oboInOwl:hasDbXref "MMO:0000272" ; a owl:Class ; rdfs:label "Blood Urea Analysis" ; rdfs:subClassOf obo:SCDO_0000133, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000194 ; owl:someValuesFrom obo:EUPATH_0021227 ] . obo:SCDO_1000606 obo:IAO_0000115 "The date on which the respondent's management details were added/recorded." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Management Details Add Date" ; rdfs:subClassOf obo:SCDO_1000537, obo:SCDO_1000590 . obo:SCDO_1000607 obo:IAO_0000115 "The Sickle in Africa core data element that collects the red blood cell count in the respondent's blood, as measured by a complete blood count." ; obo:SCDO_1000518 "Red blood cell count (RBC)" ; obo:SCDO_1000519 "cbc_redbloodcount" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "million cells/µL" ; obo:SCDO_1000739 1 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Red Blood Cell Count Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000025 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67251 ] . obo:SCDO_1000611 obo:IAO_0000115 "The Sickle in Africa core data element that collects the white blood cell count in the respondent's blood, as measured by a complete blood count." ; obo:SCDO_1000518 "White blood cell count (WBC)" ; obo:SCDO_1000519 "cbc_whitebloodcount" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "1000 cells/µL" ; obo:SCDO_1000739 2 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - White Blood Cell Count Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000027 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67244 ] . obo:SCDO_1000612 obo:IAO_0000115 "Any structural abnormality of leukocytes (nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue)." ; obo:SCDO_0000303 "Suggest the HPO update their definition. Theirs currently is \"An abnormality of leukocytes.\"" ; obo:SCDO_0000340 obo:HP_0001881 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0001881" ; a owl:Class ; rdfs:label "Abnormal Leukocyte Morphology" ; rdfs:subClassOf obo:HP_0001871, obo:HP_0002715 . obo:SCDO_1000615 obo:IAO_0000115 "The Sickle in Africa core data element that collects the platelet count in the respondent's blood, as measured by a complete blood count." ; obo:SCDO_1000518 "Platelet count" ; obo:SCDO_1000519 "cbc_platelet_count" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "1000 cells/µL" ; obo:SCDO_1000739 3 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Platelet Count Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000029 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67244 ] . obo:SCDO_1000619 obo:IAO_0000115 "The Sickle in Africa core data element that collects the concentration of hemoglobin in the respondent's blood, as measured by a complete blood count." ; obo:SCDO_1000518 "Hemoglobin" ; obo:SCDO_1000519 "cbc_hemoglobin" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "g/dL" ; obo:SCDO_1000739 4 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin - CBC Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C64783 ] . obo:SCDO_1000621 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's mean cell volume (MCV), as measured by a complete blood count." ; obo:SCDO_1000518 "Mean cell volume (MCV)" ; obo:SCDO_1000519 "cbc_mean_cell_volume" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "fL" ; obo:SCDO_1000739 5 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Mean Cell Volume Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000038 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000104 ] . obo:SCDO_1000627 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin (MCH), as measured by a complete blood count." ; obo:SCDO_1000518 "Mean cell hemoglobin (MCH)" ; obo:SCDO_1000519 "cbc_mean_cell_hemoglobin" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "pg" ; obo:SCDO_1000739 6 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Mean Cell Hemoglobin Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000290 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000025 ] . obo:SCDO_1000630 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin concentration (MCHC), as measured by a complete blood count." ; obo:SCDO_1000518 "Mean cell hemoglobin concentration (MCHC)" ; obo:SCDO_1000519 "cbc_mchc" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "g/dL" ; obo:SCDO_1000739 7 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Mean Cell Hemoglobin Concentration Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000291 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C64783 ] . obo:SCDO_1000637 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's red cell distribution width, as measured by a complete blood count." ; obo:SCDO_1000518 "Red cell distribution width (RDW)" ; obo:SCDO_1000519 "cbc_redcelldistributionwidth" ; obo:SCDO_1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 8 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Red Cell Distribution Width Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000638 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000638 obo:IAO_0000115 "Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. Usually red blood cells are a standard size of about 6-8 μm in diameter. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.[1] If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia. It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000638" ; oboInOwl:hasDbXref "EFO:0009188" ; oboInOwl:hasExactSynonym "RCDW", "RDW", "Red Cell Distribution Width" ; a owl:Class ; rdfs:label "Red Blood Cell Distribution Width" ; rdfs:subClassOf obo:CMO_0001356, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CMO_0000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0010067 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:MP_0010068 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000828 ] . obo:SCDO_1000645 obo:IAO_0000115 "The Sickle in Africa core data element that collects the level of serum creatinine in the respondent's blood." ; obo:SCDO_1000518 "Serum creatinine concentration" ; obo:SCDO_1000519 "serum_creatinine_conc" ; obo:SCDO_1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" ; obo:SCDO_1000737 "mg/dL; PX141401" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Serum Creatinine Concentration Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67015 ] . obo:SCDO_1000649 obo:IAO_0000115 "An abnormally increased amount of creatinine in the blood." ; obo:SCDO_0000303 "Suggest update to description in HPO (include the word \"abnormally\")" ; obo:SCDO_0000340 obo:HP_0003259 ; obo:SCDO_1000288 "Suggest update to description" ; oboInOwl:hasDbXref "HP:0003259" ; oboInOwl:hasExactSynonym "Elevated Creatinine", "High Blood Creatinine Level", "Increased Creatinine", "Increased Serum Creatinine" ; a owl:Class ; rdfs:label "Elevated Serum Creatinine" ; rdfs:subClassOf obo:HP_0002157, obo:HP_0012100 . obo:SCDO_1000650 obo:IAO_0000115 "The Sickle in Africa core data element that collects the concentration of creatinine in the respondent's urine." ; obo:SCDO_1000518 "Urinary creatinine concentration" ; obo:SCDO_1000519 "urinary_creatinine_conc" ; obo:SCDO_1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" ; obo:SCDO_1000737 "mg/dL; PX141601" ; obo:SCDO_1000739 4 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Urinary Creatinine Concentration Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0001213 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67015 ] . obo:SCDO_1000657 obo:IAO_0000115 "The Sickle in Africa core data element that collects the level of alanine aminotransferase in the respondent's blood." ; obo:SCDO_1000518 "Alanine aminotransferase level" ; obo:SCDO_1000519 "results_of_alanine_at_assay" ; obo:SCDO_1000735 "Liver Function Assay (PhenX protocol PX190801 unless stated otherwise)" ; obo:SCDO_1000737 "IU/L" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Alanine Aminotransferase Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000035 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67376 ] . obo:SCDO_1000660 obo:IAO_0000115 "The Sickle in Africa core data element that collects the level of aspartate aminotransferase in the respondent's blood." ; obo:SCDO_1000518 "Aspartate aminotransferase level" ; obo:SCDO_1000519 "results_of_aspartate_at_assay" ; obo:SCDO_1000735 "Liver Function Assay (PhenX protocol PX190801 unless stated otherwise)" ; obo:SCDO_1000737 "IU/L" ; obo:SCDO_1000739 2 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Aspartate Aminotransferase Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000080 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67376 ] . obo:SCDO_1000662 obo:IAO_0000115 "The Sickle in Africa core data element that collects the level of alkaline phosphatase in the respondent's blood." ; obo:SCDO_1000518 "Alkaline phosphatase level" ; obo:SCDO_1000519 "results_of_alkaline_phosphatase_assay" ; obo:SCDO_1000735 "Liver Function Assay (PhenX protocol PX190801 unless stated otherwise)" ; obo:SCDO_1000737 "IU/L" ; obo:SCDO_1000739 3 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Alkaline Phosphatase Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:VT_0000202 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67376 ] . obo:SCDO_1000663 obo:IAO_0000115 "A quantitative measurement of alkaline phosphatase present in a blood sample." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Alkaline Phosphatase Test" ; a owl:Class ; rdfs:label "Alkaline Phosphatase Blood Test" ; rdfs:subClassOf obo:NCIT_C74954, obo:SCDO_0000133 . obo:SCDO_1000669 obo:IAO_0000115 "A multiplexed qualitative point-of-care immunoassay used for the rapid diagnosis of sickle cell disorders. The test is made up of three indicators which detect the presence of hemoglobins A, S, and C, allowing the user to rapidly distinguish between normal, carrier, and sickle cell samples." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; dc:source ; a owl:Class ; rdfs:label "Sickle SCAN Rapid Test" ; rdfs:subClassOf obo:SCDO_0000522, obo:SCDO_1000577 . obo:SCDO_1000673 obo:IAO_0000115 "An indication of a person's current status in terms of living with a person as though married (in a romantic relationship and living together but not married)." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Current Partner Status" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_1000679 obo:IAO_0000115 "An indication of whether a person has previously lived with someone as though married (in a romantic relationship and lived together but were not married)." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Past Partner Status" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_1000680 obo:IAO_0000115 "The Sickle in Africa core data element that collects the level of billirubin in the respondent's blood." ; obo:SCDO_1000518 "Total billirubin concentration" ; obo:SCDO_1000519 "billirubin_total_billirubin_conc" ; obo:SCDO_1000735 "Laboratory Results: Bilirubin Level (PhenX protocol PX0810901 unless stated otherwise)" ; obo:SCDO_1000737 "mg/dL" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Total Bilirubin Concentration Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000376 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67015 ] . obo:SCDO_1000682 obo:IAO_0000115 "The Sickle in Africa core data element that collects the level of lactate dehydrogenase in the respondent's blood." ; obo:SCDO_1000518 "Lactate dehydrogenase level" ; obo:SCDO_1000519 "lactate_dehydrogenase_conc" ; obo:SCDO_1000735 "Laboratory Results: Lactate Dehydrogenase Level (PhenX protocol PX0811001 unless stated otherwise)" ; obo:SCDO_1000737 "IU/L" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Lactate Dehydrogenase Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67376 ] . obo:SCDO_1000684 obo:IAO_0000115 "A decreased or reduced level of the enzyme lactate dehydrogenase in serum." ; obo:SCDO_0000303 "The current label in HPO is \"Reduced lactate dehydrogenase B level\". Seems the \"B\" in the label and the comment that refers to the B subunit should be removed." ; obo:SCDO_0000340 obo:HP_0045041 ; obo:SCDO_1000288 "Suggest update to label" ; oboInOwl:hasDbXref "HP:0045041" ; oboInOwl:hasExactSynonym "Decreased Lactate Dehydrogenase Level" ; a owl:Class ; rdfs:label "Reduced Lactate Dehydrogenase Level" ; rdfs:subClassOf obo:HP_0045040 . obo:SCDO_1000685 obo:IAO_0000115 "The Sickle in Africa core data element that collects the reticulocyte count in the respondent's blood, as measured by a complete blood count." ; obo:SCDO_1000518 "Number of reticulocytes" ; obo:SCDO_1000519 "reticulocyte_amount" ; obo:SCDO_1000735 "Laboratory Results: Reticulocyte Count (PhenX protocol PX0810601 unless stated otherwise)" ; obo:SCDO_1000737 "1000 cells/µL" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Reticulocyte Count Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0001004 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C67244 ] . obo:SCDO_1000686 obo:IAO_0000115 "A test used to measure the reticulocyte count (number of reticulocytes in a given volume of blood)." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Retic Count", "Reticulocyte Count Test" ; a owl:Class ; rdfs:label "Reticulocyte Count Assay" ; rdfs:subClassOf obo:SCDO_0000133 . obo:SCDO_1000687 obo:IAO_0000115 "The Sickle in Africa core data element that records the hemoglobins for which assay results were recorded." ; obo:SCDO_1000517 """1, Hb A 2, Hb F 3, Hb S 4, Hb C 5, Hb E 6, Hb A2 7, Hb D-Punjab 8, Hb G-Philadelphia 9, Hb O-Arab""" ; obo:SCDO_1000518 "For which hemoglobins were assay results recorded?" ; obo:SCDO_1000519 "scd_hemoglobin_assay_results" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "Select all relevant options" ; obo:SCDO_1000739 1 ; obo:SCDO_1000748 "LH" ; obo:SCDO_1000749 "checkbox" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hb Assay Results Recorded Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000495 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0000513 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0000514 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0000528 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0004139 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_0005446 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000016 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000364 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000689 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000688 ] . obo:SCDO_1000688 obo:IAO_0000115 "The hemoglobins for which assay results were recorded." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hemoglobin Assay Results Recorded" ; rdfs:subClassOf obo:SCDO_1000576 . obo:SCDO_1000689 obo:IAO_0000115 "Hemoglobin G Philadelphia (HbG Phil) is a structural variant of the hemoglobin molecule that involves the alpha chain rather than the beta chain. It has a frequency of about 1 in 5,000 African Americans, but has been reported in other ethnic groups in the Mediterranean region as well, HbG Phil itself has no clinical consequences. The only finding of clinical interest is the mild microcytosis. While this molecule has no clinical consequences, the presence helps to distinguish HbG from HbD that shares its electrophoretic migration on HPLC and gel electrophoresis and which does have consequences when it occurs with sickle trait." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000689" ; oboInOwl:hasDbXref "LNC:LP16433-2" ; oboInOwl:hasExactSynonym "Hb G-Phil", "Hb G-Philadelphia", "HbG Phil", "Hemoglobin G Philadelphia" ; a owl:Class ; rdfs:label "Hemoglobin G-Philadelphia" ; rdfs:subClassOf obo:SCDO_0006921 . obo:SCDO_1000690 obo:IAO_0000115 "The amount of hemoglobin A present in a specified volume of blood." ; obo:SCDO_1000288 "Negligible" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin A Level" ; a owl:Class ; rdfs:label "Hemoglobin A Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_0000976 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000241 ] . obo:SCDO_1000691 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A." ; obo:SCDO_1000518 "Record the levels of Hb A if measured." ; obo:SCDO_1000519 "hba2" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 2 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(1)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin A Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000690 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000692 obo:IAO_0000115 "The amount of hemoglobin S present in a specified volume of blood." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin S Level" ; a owl:Class ; rdfs:label "Hemoglobin S Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000784 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000844 ] . obo:SCDO_1000693 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin S." ; obo:SCDO_1000518 "Record the levels of Hb S if measured." ; obo:SCDO_1000519 "hbs" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 4 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(3)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin S Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000692 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000694 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin C." ; obo:SCDO_1000518 "Record the levels of Hb C if measured." ; obo:SCDO_1000519 "hbc" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 5 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(4)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin C Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000695 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000695 obo:IAO_0000115 "The amount of hemoglobin C present in a specified volume of blood." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin C Level" ; a owl:Class ; rdfs:label "Hemoglobin C Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000036 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000806 ] . obo:SCDO_1000696 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin E." ; obo:SCDO_1000518 "Record the levels of Hb E if measured." ; obo:SCDO_1000519 "hbe" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 6 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(5)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin E Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000697 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000697 obo:IAO_0000115 "The amount of hemoglobin E present in a specified volume of blood." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin E Level" ; a owl:Class ; rdfs:label "Hemoglobin E Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000179 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000181 ] . obo:SCDO_1000698 obo:IAO_0000115 "The amount of hemoglobin A2 present in a specified volume of blood." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin A2 Level" ; a owl:Class ; rdfs:label "Hemoglobin A2 Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0045048 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000187 ] . obo:SCDO_1000699 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A2." ; obo:SCDO_1000518 "Record the levels of Hb A2 if measured." ; obo:SCDO_1000519 "hb_a2" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 7 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(6)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin A2 Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000698 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000700 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin D-Punjab." ; obo:SCDO_1000518 "Record the levels of Hb D-Punjab if measured." ; obo:SCDO_1000519 "hb_dpunjab" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 8 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(7)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin D-Punjab Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000701 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000701 obo:IAO_0000115 "The amount of hemoglobin D-Punjab present in a specified volume of blood." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin D-Punjab Level" ; a owl:Class ; rdfs:label "Hemoglobin D-Punjab Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000289 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000816 ] . obo:SCDO_1000702 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin G-Philadelphia." ; obo:SCDO_1000518 "Record the levels of Hb G-Philadelphia if measured." ; obo:SCDO_1000519 "hb_gphilidelphia" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 9 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(8)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin G-Philadelphia Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000703 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000703 obo:IAO_0000115 "The amount of hemoglobin G-Philadelphia present in a specified volume of blood." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin G-Philadelphia Level" ; a owl:Class ; rdfs:label "Hemoglobin G-Philadelphia Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000290 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000817 ] . obo:SCDO_1000704 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin O-Arab." ; obo:SCDO_1000518 "Record the levels of Hb O-Arab if measured." ; obo:SCDO_1000519 "hb_o_arab" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 10 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(9)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin O-Arab Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000705 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000705 obo:IAO_0000115 "The amount of hemoglobin O-Arab present in a specified volume of blood." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin O-Arab Level" ; a owl:Class ; rdfs:label "Hemoglobin O-Arab Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000291 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000818 ] . obo:SCDO_1000706 obo:IAO_0000115 "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin F." ; obo:SCDO_1000518 "Record the levels of Hb F if measured." ; obo:SCDO_1000519 "hbf_percent" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 3 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[scd_hemoglobin_assay_results(2)] = '1'" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hemoglobin F Level Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000707 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000707 obo:IAO_0000115 "The amount of hemoglobin F present in a specified volume of blood." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin F Level" ; a owl:Class ; rdfs:label "Hemoglobin F Level" ; rdfs:subClassOf obo:SCDO_0000546, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000094 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000117 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000580 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_0000810 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000005 ; owl:someValuesFrom obo:SCDO_1000063 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000251 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000015 ; owl:someValuesFrom obo:SCDO_0000895 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:CHMO_0001009 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000182 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000547 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0011904 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000292 ] . obo:SCDO_1000708 obo:IAO_0000115 "The sex of the respondent's spouse, as provided by the respondent." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Sex of Spouse" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_1000709 obo:IAO_0000115 "The sex of the respondent's partner (where the partner is not a spouse), as provided by the respondent." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Sex of Partner" ; rdfs:subClassOf obo:NCIT_C16495 . obo:SCDO_1000711 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's body temperature." ; obo:SCDO_1000518 "Patient's body temperature" ; obo:SCDO_1000519 "body_temperature" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000737 "degrees Celsius" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000743 13 ; obo:SCDO_1000744 46 ; obo:SCDO_1000749 "text" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Body Temperature Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000015 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C42559 ] . obo:SCDO_1000714 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's respiratory rate." ; obo:SCDO_1000518 "Patient's respiratory rate" ; obo:SCDO_1000519 "respiratory_rate" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000737 "breaths per minute" ; obo:SCDO_1000739 3 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Respiratory Rate Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000993 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C49674 ] . obo:SCDO_1000717 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's partial pressure of carbon dioxide in their arterial blood, as measured by an arterial blood gas test." ; obo:SCDO_1000518 "Partial pressure of carbon dioxide (PaCO2)" ; obo:SCDO_1000519 "partial_pressure_co2" ; obo:SCDO_1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" ; obo:SCDO_1000737 "mmHg" ; obo:SCDO_1000739 1 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Partial Pressure CO2 Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000283 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000272 ] . obo:SCDO_1000722 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's partial pressure of oxygen their arterial blood, as measured by an arterial blood gas test." ; obo:SCDO_1000518 "Partial pressure of oxygen (PaO2)" ; obo:SCDO_1000519 "partial_pressure_of_oxygen" ; obo:SCDO_1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" ; obo:SCDO_1000737 "mmHg" ; obo:SCDO_1000739 2 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Partial Pressure O2 Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000723 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000272 ] . obo:SCDO_1000723 obo:IAO_0000115 "The pressure exerted by oxygen dissolved in the blood, indicating how well oxygen is able to move from the airspace of the lungs into the blood." ; obo:SCDO_1000288 "Few but available definitions not adequate" ; oboInOwl:hasDbXref "CMO:0000381" ; oboInOwl:hasExactSynonym "Oxygen Tension", "PaO2", "Partial Pressure of Blood Oxygen", "Partial Pressure of Blood Oxygen (Po2)", "Partial Pressure of Oxygen (PaO2)", "Po2" ; a owl:Class ; rdfs:label "Partial Pressure of Oxygen" ; rdfs:subClassOf obo:CMO_0000225, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000819 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000838 ] . obo:SCDO_1000724 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's arterial oxygen saturation (oxyhemoglobin saturation), as measured by an arterial blood gas test." ; obo:SCDO_1000518 "Oxyhemoglobin saturation (HbO2)" ; obo:SCDO_1000519 "oxyhemoglobin_saturation" ; obo:SCDO_1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 3 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Oxyhemoglobin Saturation Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000849 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000725 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's carboxyhemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test." ; obo:SCDO_1000518 "Carboxyhemoglobin (COHb)" ; obo:SCDO_1000519 "carboxyhemoglobin" ; obo:SCDO_1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 4 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Carboxyhemoglobin Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000728 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000726 obo:IAO_0000115 "The Sickle in Africa core data element that collects the respondent's methemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test." ; obo:SCDO_1000518 "Methemoglobin (MetHb)" ; obo:SCDO_1000519 "methemoglobin" ; obo:SCDO_1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" ; obo:SCDO_1000737 "%" ; obo:SCDO_1000739 5 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Methemoglobin Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000727 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000187 ] . obo:SCDO_1000727 obo:IAO_0000115 "The ratio of methemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Used term from existing ontology but will suggest they update their label and description to ours." ; oboInOwl:hasDbXref "EFO:0009226" ; oboInOwl:hasExactSynonym "HGBMHGB", "MetHb Saturation", "Methemoglobin Saturation", "Methemoglobin to Total Hemoglobin Ratio Measurement", "Methemoglobin/Total Hemoglobin" ; a owl:Class ; rdfs:label "Methemoglobin to Total Hemoglobin Ratio" ; rdfs:subClassOf obo:CMO_0000508, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000729 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000815 ] . obo:SCDO_1000728 obo:IAO_0000115 "The ratio of carboxyhemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Used term from existing ontology but will suggest they update their label and description to ours." ; oboInOwl:hasDbXref "EFO:0009203" ; oboInOwl:hasExactSynonym "COHb Saturation", "Carboxyhemoglobin Saturation", "Carboxyhemoglobin/Total Hemoglobin" ; a owl:Class ; rdfs:label "Carboxyhemoglobin to Total Hemoglobin Ratio" ; rdfs:subClassOf obo:CMO_0000508, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_0000071 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000807 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000814 ] . obo:SCDO_1000729 obo:IAO_0000115 "An elevated concentration in the blood of methemoglobin, which is the ferric (Fe(3+)) form of hemoglobin." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Methemoglobin Increased", "Raised Methemoglobin" ; a owl:Class ; rdfs:comment "Injury or toxic agents can convert a larger proportion of hemoglobin to methemoglobin, which does not function reversibly as an oxygen carrier and thus less oxygen is made available to the tissues." ; rdfs:label "Increased Methemoglobin" ; rdfs:subClassOf obo:HP_0020063 . obo:SCDO_1000730 obo:IAO_0000115 "A site-specific unique identifier assigned to a study participant by the data collectors at the data collection site." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Site Participant Number" ; rdfs:subClassOf obo:NCIT_C69256 . obo:SCDO_1000731 obo:IAO_0000115 "A unique identifier provided on SCD passports." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SCD Passport Number" ; rdfs:subClassOf obo:NCIT_C69256 . obo:SCDO_1000732 obo:IAO_0000115 "The Sickle in Africa core data element that records the unique identifier that was assigned to the study participant's data when it was registered in the SickleInAfrica data registry." ; obo:SCDO_1000518 "SickleInAfrica Participant Number" ; obo:SCDO_1000519 "record_id" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - SickleInAfrica Participant Number" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000470 ] . obo:SCDO_1000734 obo:IAO_0000115 "The Sickle in Africa core data element that calculates the respondent's age in months, using the visit date and birth date collected by other core data elements." ; obo:SCDO_1000518 "Calculated age (in months)" ; obo:SCDO_1000519 "calc_age_on_day_of_visit" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000736 "datediff([date_today],[date_of_birth], \"M\",\"dmy\")" ; obo:SCDO_1000737 "Age on day of visit" ; obo:SCDO_1000739 10 ; obo:SCDO_1000748 "RH" ; obo:SCDO_1000749 "calc" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Age In Months Calculation" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000545 ] . obo:SCDO_1000735 obo:IAO_0000115 "Records the section of a CRF in which a data element occurs." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "in CRF section" . obo:SCDO_1000736 obo:IAO_0000115 "Records the calculation used to automatically calculate the value for a data element in REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has calculation equation" . obo:SCDO_1000737 obo:IAO_0000115 "Records a data element's field note (a note provided below the answer field)." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has field note" . obo:SCDO_1000738 obo:IAO_0000115 "A data capture instrument designed and applied by the Sickle In Africa Consortium." ; obo:SCDO_1000288 "None" ; obo:SCDO_1000740 """Consent Demographics SCD Diagnosis Details Management Details Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise) Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise) Liver Function Assay (PhenX protocol PX190801 unless stated otherwise) Laboratory Results: Bilirubin Level (PhenX protocol PX0810901 unless stated otherwise) Laboratory Results: Lactate Dehydrogenase Level (PhenX protocol PX0811001 unless stated otherwise) Laboratory Results: Reticulocyte Count (PhenX protocol PX0810601 unless stated otherwise) Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise) Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)""" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica Core Data Element Instrument" ; rdfs:subClassOf obo:NCIT_C91105 . obo:SCDO_1000739 obo:IAO_0000115 "Records the order in which a data element appears in a specific section of a specific CRF/questionnaire/instrument. This is provided in the form of a number which is relative to the order numbers of other data elements of the section." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "order in CRF section" . obo:SCDO_1000740 obo:IAO_0000115 "Used to provide a list of sections present in a questionnaire/instrument." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000476 ; rdfs:label "has sections" . obo:SCDO_1000741 obo:IAO_0000115 "Records the type of validation used for a data element in REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:label "has redcap validation" . obo:SCDO_1000742 obo:IAO_0000115 "Records the branching logic applied to a data element in REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has branching logic" . obo:SCDO_1000743 obo:IAO_0000115 "Records the mainimum value that is accepted for a data element that has validation applied to it in REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has redcap min number validation" . obo:SCDO_1000744 obo:IAO_0000115 "Records the maximum value that is accepted for a data element that has validation applied to it in REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has redcap max number validation" . obo:SCDO_1000745 obo:IAO_0000115 "Records the field annotations of a data element in REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has redcap field annotation" . obo:SCDO_1000746 obo:IAO_0000115 "Used to show if a data element is considered an \"identifier\" (meaning it contains identifying information)." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "is identifier" . obo:SCDO_1000747 obo:IAO_0000115 "Used to show if a data element is a required field. \"y\" is assigned to it if the data element is a required field." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "required field" . obo:SCDO_1000748 obo:IAO_0000115 "Records the custom alignment of a data element in REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:label "custom alignment" . obo:SCDO_1000749 obo:IAO_0000115 "Records a data element's field type, as per REDCap." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has field type" . obo:SCDO_1000750 obo:IAO_0000115 "Used to record the matrix group that a data element occurs in." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "in matrix group" . obo:SCDO_1000751 obo:IAO_0000115 "The Sickle in Africa core data element that collects the total concentration of hemoglobin in the respondent's blood." ; obo:SCDO_1000518 "Total hemoglobin (Hbtotal)" ; obo:SCDO_1000519 "total_hemoglobin" ; obo:SCDO_1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" ; obo:SCDO_1000737 "g/dL" ; obo:SCDO_1000739 11 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Total Hemoglobin Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:CMO_0000506 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C64783 ] . obo:SCDO_1000753 obo:IAO_0000115 "An assay to determine the body temperature of an evaluant using an oral thermometer." ; obo:SCDO_0000340 ; obo:SCDO_0000479 "PhenX protocol: Body Temperature - Oral Thermometers #810102" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Oral Temperature Taking" ; a owl:Class ; rdfs:label "Body Temperature - Oral Measurement Assay" ; rdfs:subClassOf obo:OBI_0002140 . obo:SCDO_1000754 obo:IAO_0000115 "An assay to determine the body temperature of an evaluant using a tympanic (i.e. ear) thermometer." ; obo:SCDO_0000479 "PhenX protocol: Body Temperature - Tympanic Thermometers #810101" ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Tympanic Temperature Taking" ; a owl:Class ; rdfs:label "Body Temperature - Tympanic Measurement Assay" ; rdfs:subClassOf obo:OBI_0002140 . obo:SCDO_1000755 obo:IAO_0000115 "The temperature of the oral cavity." ; obo:SCDO_0000340 obo:VSO_0000025 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000755" ; oboInOwl:hasDbXref "VSO:0000025" ; oboInOwl:hasExactSynonym "Oral Body Temperature" ; a owl:Class ; rdfs:label "Oral Temperature" ; rdfs:subClassOf obo:CMO_0000015 . obo:SCDO_1000756 obo:IAO_0000115 "The temperature of the external acoustic tube." ; obo:SCDO_0000340 obo:VSO_0000045 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000756" ; oboInOwl:hasDbXref "VSO:0000045" ; oboInOwl:hasExactSynonym "Tympanic (ear) Temperature", "Tympanic Body Temperature" ; a owl:Class ; rdfs:label "Tympanic Temperature" ; rdfs:subClassOf obo:CMO_0000015 . obo:SCDO_1000757 obo:IAO_0000115 "The temperature of the lumen of the rectum." ; obo:SCDO_0000340 obo:VSO_0000033 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000757" ; oboInOwl:hasDbXref "VSO:0000033" ; oboInOwl:hasExactSynonym "Rectal Body Temperature" ; a owl:Class ; rdfs:label "Rectal Temperature" ; rdfs:subClassOf obo:CMO_0000015 . obo:SCDO_1000758 obo:IAO_0000115 "The temperature of the axillary fossa." ; obo:SCDO_0000340 obo:VSO_0000003 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000758" ; oboInOwl:hasDbXref "VSO:0000003" ; oboInOwl:hasExactSynonym "Armpit Temperature", "Axillary (armpit) Temperature" ; a owl:Class ; rdfs:label "Axillary Temperature" ; rdfs:subClassOf obo:CMO_0000015 . obo:SCDO_1000759 obo:IAO_0000115 "The Sickle in Africa core data element that records the type of body temperature that was taken for the respondent." ; obo:SCDO_1000517 """1, Oral Temperature 2, Tympanic (ear) Temperature 3, Axillary (armpit) Temperature 4, Rectal Temperature""" ; obo:SCDO_1000518 "Type of body temperature taken" ; obo:SCDO_1000519 "type_of_temp" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000739 2 ; obo:SCDO_1000749 "dropdown" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Type of Temperature Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000755 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000756 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000757 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000758 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000763 ] . obo:SCDO_1000763 a owl:Class ; rdfs:label "Type of Body Temperature" ; rdfs:subClassOf obo:SCDO_1000576 . obo:SCDO_1000766 obo:IAO_0000115 "An answer to a question where the answer is a year between 1900 and the current year, selected from a provided list of years." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Year 1900 - Current" ; rdfs:subClassOf obo:NCIT_C91106 . obo:SCDO_1000767 obo:IAO_0000115 "An answer to a question where the answer is a month between 1 - 12, selected form a list of months." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Month 1 - 12" ; rdfs:subClassOf obo:NCIT_C91106 . obo:SCDO_1000768 obo:SCDO_0000303 "Waiting for description for this." ; a owl:Class ; rdfs:label "Acide" ; rdfs:subClassOf obo:SCDO_1000577 . obo:SCDO_1000769 obo:IAO_0000115 "Waiting for description for this." ; a owl:Class ; rdfs:label "Basique" ; rdfs:subClassOf obo:SCDO_1000577 . obo:SCDO_1000771 obo:IAO_0000115 "A relationship between a data element and the unit of measurement used, as a standard, for the information that is collected by the data element." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:domain obo:SCDO_1000474 ; rdfs:label "has answer standard unit" ; rdfs:range obo:UO_0000000 ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000772 obo:IAO_0000115 "A relationship between a Diagnostic Measurement and a Phenotype, where the Phenotype is a possible finding of the Diagnostic Measurement, depending on the value recorded for the Diagnostic Measurement." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has possible finding" ; rdfs:range obo:HP_0000118 ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000773 obo:IAO_0000115 "A relationship between an Abnormal Phenotype that is a diagnosis of a condition and a Phenotype that is a finding from a Diagnostic Measurement, where the Phenotype that is a finding is used as evidence to diagnose patients with the Abnormal Phenotype that is a diagnosis." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "diagnosed using finding" ; rdfs:range obo:OGMS_0000023 ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000774 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.03" ; oboInOwl:hasExactSynonym "D57.03", "Hb-SS disease with cerebral vascular involvement", "Sickle cell anemia with cerebral vascular involvement" ; a owl:Class ; rdfs:label "D57.03 Hb-SS disease with cerebral vascular involvement" ; rdfs:subClassOf obo:SCDO_0000312, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_1000037 ] . obo:SCDO_1000775 obo:IAO_0000115 "-" ; obo:SCDO_1000176 "yes" ; obo:SCDO_1000288 "Few but definitions not available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.09" ; oboInOwl:hasExactSynonym "D57.09", "Hb-SS disease with crisis with other specified complication", "Sickle cell anemia with crisis with other specified complication" ; a owl:Class ; rdfs:label "D57.09 Hb-SS disease with crisis with other specified complication" ; rdfs:subClassOf obo:SCDO_0000312, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C131682 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_1000776 obo:IAO_0000115 "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for males for a particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25555 ; oboInOwl:hasExactSynonym "has lower limit of normal for males" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has LLN male" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000777 obo:IAO_0000115 "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for females for a particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25555 ; oboInOwl:hasExactSynonym "has lower limit of normal for females" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has LLN female" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000778 obo:IAO_0000115 "Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for children for a particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25555 ; oboInOwl:hasExactSynonym "has lower limit of normal for children" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has LLN pediatric" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000779 obo:IAO_0000115 "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for males for a particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25555 ; oboInOwl:hasExactSynonym "has upper limit of normal for males" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has ULN male" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000780 obo:IAO_0000115 "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for females for a particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25555 ; oboInOwl:hasExactSynonym "has upper limit of normal for females" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has ULN female" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000781 obo:IAO_0000115 "Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for children for a particular laboratory result or other quantitative parameter." ; obo:SCDO_1000288 "None" ; dc:source obo:NCIT_C25555 ; oboInOwl:hasExactSynonym "has upper limit of normal for children" ; a owl:DatatypeProperty, owl:FunctionalProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has ULN pediatric" ; rdfs:range xsd:decimal ; rdfs:subPropertyOf owl:topDataProperty . obo:SCDO_1000782 obo:IAO_0000115 "A relationship between a Diagnostic Measurement and the Unit of Measurement used for the values provided by the data properties that specify upper (ULN) or lower (LLN) limit of normal for the Diagnostic Measurement." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:domain obo:SCDO_0000728 ; rdfs:label "has reference range standard unit" ; rdfs:range obo:UO_0000000 . obo:SCDO_1000783 obo:IAO_0000115 "When there is no deviation from the normal concentration of hemoglobin in the blood." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Normal Hemoglobin Concentration" ; rdfs:subClassOf obo:SCDO_0009613, obo:SCDO_1000821 . obo:SCDO_1000784 obo:IAO_0000115 "A lack of production of hemoglobin S." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasDbXref "MEDDRA:10055604" ; oboInOwl:hasExactSynonym "Absent Haemoglobin S", "Haemoglobin S Absent", "Hemoglobin S Absent", "Normal Haemoglobin S Level", "Normal Hemoglobin S Level" ; a owl:Class ; rdfs:label "Absent Hemoglobin S" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000785 obo:IAO_0000115 "A relationship between a clinical code (such as ICD10 code) and a Phenotype, where the code can only be applied in instances where the phenotype is present." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "code requires phenotype" ; rdfs:subPropertyOf owl:topObjectProperty . obo:SCDO_1000786 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.213" ; oboInOwl:hasExactSynonym "D57.213", "Sickle Cell Disease-SC with cerebral vascular involvement", "Sickle-cell/Hb-C disease with cerebral vascular involvement" ; a owl:Class ; rdfs:label "D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement" ; rdfs:subClassOf obo:SCDO_0000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_1000037 ] . obo:SCDO_1000787 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.218" ; oboInOwl:hasExactSynonym "D57.218", "Sickle Cell Disease-SC with crisis with other specified complication", "Sickle-cell/Hb-C disease with crisis with other specified complication" ; a owl:Class ; rdfs:label "D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication" ; rdfs:subClassOf obo:SCDO_0000318, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001059 ] . obo:SCDO_1000788 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.413" ; oboInOwl:hasExactSynonym "D57.413" ; a owl:Class ; rdfs:label "D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement" ; rdfs:subClassOf obo:SCDO_0000325, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_1000037 ] . obo:SCDO_1000789 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.418" ; oboInOwl:hasExactSynonym "D57.418", "Sickle-cell thalassemia, unspecified, with crisis with other specified complication" ; a owl:Class ; rdfs:label "D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication" ; rdfs:subClassOf obo:SCDO_0000325, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C95539 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_1000790 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.42" ; oboInOwl:hasExactSynonym "D57.42", "Sickle-cell thalassemia beta zero without crisis" ; a owl:Class ; rdfs:label "D57.42 Sickle-cell thalassemia beta zero without crisis" ; rdfs:subClassOf obo:SCDO_0000323, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C3833 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C98835 ] . obo:SCDO_1000791 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.43" ; oboInOwl:hasExactSynonym "D57.43", "Sickle-cell thalassemia beta zero with crisis" ; a owl:Class ; rdfs:label "D57.43 Sickle-cell thalassemia beta zero with crisis" ; rdfs:subClassOf obo:SCDO_0000323, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_1000792 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.431" ; oboInOwl:hasExactSynonym "D57.431", "Sickle-cell thalassemia beta zero with acute chest syndrome" ; a owl:Class ; rdfs:label "D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome" ; rdfs:subClassOf obo:SCDO_1000791, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_1000793 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.432" ; oboInOwl:hasExactSynonym "D57.432", "Sickle-cell thalassemia beta zero with splenic sequestration" ; a owl:Class ; rdfs:label "D57.432 Sickle-cell thalassemia beta zero with splenic sequestration" ; rdfs:subClassOf obo:SCDO_1000791, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0007161 ] . obo:SCDO_1000794 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.433" ; oboInOwl:hasExactSynonym "D57.433", "Sickle-cell thalassemia beta zero with cerebral vascular involvement" ; a owl:Class ; rdfs:label "D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement" ; rdfs:subClassOf obo:SCDO_1000791, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_1000037 ] . obo:SCDO_1000795 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.438" ; oboInOwl:hasExactSynonym "D57.438", "Sickle-cell thalassemia beta zero with crisis with other specified complication" ; a owl:Class ; rdfs:label "D57.438 Sickle-cell thalassemia beta zero with crisis with other specified complication" ; rdfs:subClassOf obo:SCDO_1000791, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_1000796 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.439" ; oboInOwl:hasExactSynonym "D57.439", "Sickle-cell thalassemia beta zero with crisis, unspecified" ; a owl:Class ; rdfs:label "D57.439 Sickle-cell thalassemia beta zero with crisis, unspecified" ; rdfs:subClassOf obo:SCDO_1000791, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C98835 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_1000797 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.44" ; oboInOwl:hasExactSynonym "D57.44", "Sickle-cell thalassemia beta minus without crisis", "Sickle-cell thalassemia beta plus without crisis" ; a owl:Class ; rdfs:label "D57.44 Sickle-cell thalassemia beta plus without crisis" ; rdfs:subClassOf obo:SCDO_0000323, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:NCIT_C3833 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001056 ] . obo:SCDO_1000798 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.45" ; oboInOwl:hasExactSynonym "D57.45", "Sickle-cell thalassemia beta minus with crisis", "Sickle-cell thalassemia beta plus with crisis" ; a owl:Class ; rdfs:label "D57.45 Sickle-cell thalassemia beta plus with crisis" ; rdfs:subClassOf obo:SCDO_0000323, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001056 ] . obo:SCDO_1000799 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.451" ; oboInOwl:hasExactSynonym "D57.451", "Sickle-cell thalassemia beta minus with acute chest syndrome", "Sickle-cell thalassemia beta plus with acute chest syndrome" ; a owl:Class ; rdfs:label "D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome" ; rdfs:subClassOf obo:SCDO_1000798, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:DOID_1584 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001056 ] . obo:SCDO_1000800 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.452" ; oboInOwl:hasExactSynonym "D57.452", "Sickle-cell thalassemia beta minus with splenic sequestration", "Sickle-cell thalassemia beta plus with splenic sequestration" ; a owl:Class ; rdfs:label "D57.452 Sickle-cell thalassemia beta plus with splenic sequestration" ; rdfs:subClassOf obo:SCDO_1000798, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0007161 ] . obo:SCDO_1000801 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.453" ; oboInOwl:hasExactSynonym "D57.453", "Sickle-cell thalassemia beta minus with cerebral vascular involvement", "Sickle-cell thalassemia beta plus with cerebral vascular involvement" ; a owl:Class ; rdfs:label "D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement" ; rdfs:subClassOf obo:SCDO_1000798, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001056 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_1000037 ] . obo:SCDO_1000802 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.458" ; oboInOwl:hasExactSynonym "D57.458", "Sickle-cell thalassemia beta minus with crisis with other specified complication", "Sickle-cell thalassemia beta plus with crisis with other specified complication" ; a owl:Class ; rdfs:label "D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication" ; rdfs:subClassOf obo:SCDO_1000798, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001056 ] . obo:SCDO_1000803 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.459" ; oboInOwl:hasExactSynonym "D57.459", "Sickle-cell thalassemia beta minus with crisis, unspecified", "Sickle-cell thalassemia beta plus with crisis, unspecified" ; a owl:Class ; rdfs:label "D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified" ; rdfs:subClassOf obo:SCDO_1000798, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001056 ] . obo:SCDO_1000804 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.818" ; oboInOwl:hasExactSynonym "D57.818" ; a owl:Class ; rdfs:label "D57.818 Other sickle-cell disorders with crisis with other specified complication" ; rdfs:subClassOf obo:SCDO_0000331, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ] . obo:SCDO_1000805 obo:IAO_0000115 "-" ; obo:SCDO_1000288 "Few but definitions not freely available" ; dc:source ; oboInOwl:hasDbXref "ICD10CM:D57.813" ; oboInOwl:hasExactSynonym "D57.813" ; a owl:Class ; rdfs:label "D57.813 Other sickle-cell disorders with cerebral vascular involvement" ; rdfs:subClassOf obo:SCDO_0000331, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_0001053 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000785 ; owl:someValuesFrom obo:SCDO_1000037 ] . obo:SCDO_1000806 obo:IAO_0000115 "A lack of production of hemoglobin C." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Absent Haemoglobin C", "Haemoglobin C Absent", "Hemoglobin C Absent", "Normal Haemoglobin C Level", "Normal Hemoglobin C Level" ; a owl:Class ; rdfs:label "Absent Hemoglobin C" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000807 obo:IAO_0000115 "An elevated concentration in the blood of carboxyhemoglobin, which is the form of hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO)." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Carboxyhemoglobin Increased", "Raised Carboxyhemoglobin" ; a owl:Class ; rdfs:label "Increased Carboxyhemoglobin" ; rdfs:subClassOf obo:HP_0020063 . obo:SCDO_1000808 obo:IAO_0000115 "An abnormal reduction in the amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Arterial Oxygen Saturation Decreased", "Decreased Arterial HbO2", "Decreased Arterial Oxyhemoglobin Saturation", "Decreased Arterial SaO2", "Decreased Arterial Sats", "Decreased Oxygen Saturation of Arterial Blood", "Decreased Oxyhemoglobin/Total Hemoglobin", "Low Arterial Oxygen Saturation" ; a owl:Class ; rdfs:label "Decreased Arterial Oxygen Saturation" ; rdfs:subClassOf obo:MP_0002329 . obo:SCDO_1000812 obo:IAO_0000115 "A phenotype of the body's metabolism or homeostasis that is not clinically abnormal." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Normal Metabolism/Homeostasis Phenotype" ; rdfs:subClassOf obo:MP_0005376 . obo:SCDO_1000813 obo:IAO_0000115 "When the degree to which oxygen is bound to hemoglobin in arterial blood is in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal Arterial Blood Oxygen Saturation" ; a owl:Class ; rdfs:label "Normal Arterial Oxygen Saturation" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000814 obo:IAO_0000115 "When the level of carboxyhemoglobin detected in a sample of blood falls in the normal range for carboxyhemoglobin." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Carboxyhemoglobin Normal", "Normal Carboxyhemoglobin Concentration" ; a owl:Class ; rdfs:label "Normal Carboxyhemoglobin Level" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000815 obo:IAO_0000115 "When the level of methemoglobin detected in a sample of blood falls in the normal range for methemoglobin." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "MetHb Normal", "Normal MetHb Level", "Normal Methemoglobin Concentration" ; a owl:Class ; rdfs:label "Normal Methemoglobin Level" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000816 obo:IAO_0000115 "A lack of production of hemoglobin D-Punjab." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Absent Haemoglobin D-Punjab", "Haemoglobin D-Punjab Absent", "Hemoglobin D-Punjab Absent", "Normal Haemoglobin D-Punjab Level", "Normal Hemoglobin D-Punjab Level" ; a owl:Class ; rdfs:label "Absent Hemoglobin D-Punjab" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000817 obo:IAO_0000115 "A lack of production of hemoglobin G-Philadelphia." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Absent Haemoglobin G-Philadelphia", "Haemoglobin G-Philadelphia Absent", "Hemoglobin G-Philadelphia Absent", "Normal Haemoglobin G-Philadelphia Level", "Normal Hemoglobin G-Philadelphia Level" ; a owl:Class ; rdfs:label "Absent Hemoglobin G-Philadelphia" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000818 obo:IAO_0000115 "A lack of production of hemoglobin O-Arab." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Absent Haemoglobin O-Arab", "Haemoglobin O-Arab Absent", "Hemoglobin O-Arab Absent", "Normal Haemoglobin O-Arab Level", "Normal Hemoglobin O-Arab Level" ; a owl:Class ; rdfs:label "Absent Hemoglobin O-Arab" ; rdfs:subClassOf obo:SCDO_1000783 . obo:SCDO_1000819 obo:IAO_0000115 "An abnormal reduction in the pressure exerted by oxygen dissolved in the blood." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Arterial Oxygen Partial Pressure Decreased", "Decreased Oxygen Tension", "Decreased PO2", "Decreased PaO2", "Decreased Partial Pressure of Blood Oxygen", "PO2 Decreased" ; a owl:Class ; rdfs:label "Decreased Partial Pressure of Oxygen" ; rdfs:subClassOf obo:MP_0002329 . obo:SCDO_1000820 obo:IAO_0000115 "The observable morphological and physiological characteristics of the human blood cells or the organs associated with the development and formation of blood cells that are manifested through development and lifespan." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:source obo:MP_0005397 ; oboInOwl:hasExactSynonym "Haematopoietic System Phenotype", "Haemopoietic System Phenotype", "Hemopoietic System Phenotype" ; a owl:Class ; rdfs:label "Hematopoietic System Phenotype" ; rdfs:subClassOf obo:OGMS_0000023 . obo:SCDO_1000821 obo:IAO_0000115 "A phenotype of the body's hematopoietic system that is not clinically abnormal." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Normal Hematopoietic System Phenotype" ; rdfs:subClassOf obo:SCDO_1000820 . obo:SCDO_1000822 obo:IAO_0000115 "When the number of red blood cells in a specified volume of blood falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal RBC Count", "RBC Count Normal", "Red Blood Cell Count Normal" ; a owl:Class ; rdfs:label "Normal Red Blood Cell Count" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000823 obo:IAO_0000115 "When the number of white blood cells in a specified volume of blood falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal WBC Count", "WBC Count Normal", "White Blood Cell Count Normal" ; a owl:Class ; rdfs:label "Normal White Blood Cell Count" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000824 obo:IAO_0000115 "When the number of platelets in a specified volume of blood falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Platelet Count Normal" ; a owl:Class ; rdfs:label "Normal Platelet Count" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000825 obo:IAO_0000115 "When the average volume or size of a single red blood cell falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "MCV Normal", "Mean Cell Volume Normal", "Mean Corpuscular Volume Normal", "Normal MCV", "Normal Mean Cell Volume" ; a owl:Class ; rdfs:label "Normal Mean Corpuscular Volume" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000826 obo:IAO_0000115 "When the average amount of hemoglobin per red blood cell (calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood) falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "MCH Normal", "Mean Cell Hemoglobin Normal", "Mean Corpuscular Hemoglobin Level Normal", "Mean Corpuscular Hemoglobin Normal", "Normal MCH", "Normal Mean Cell Hemoglobin", "Normal Mean Corpuscular Hemoglobin", "Normal Mean Corpuscular Hemoglobin Level" ; a owl:Class ; rdfs:label "Normal Mean Corpuscular Hemoglobin" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000827 obo:IAO_0000115 "When the amount of hemoglobin in a given volume of packed red blood cells falls in the normal range." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "MCHC Normal", "Mean Corpuscular Hemoglobin Concentration Normal", "Normal MCHC", "Normal Mean Cell Hemoglobin Concentration" ; a owl:Class ; rdfs:label "Normal Mean Corpuscular Hemoglobin Concentration" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000828 obo:IAO_0000115 "When the range of variation of red blood cell (RBC) volume falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal RBC Distribution Width", "Normal RCDW", "RBC Distribution Width Normal", "RCDW Normal", "Red Blood Cell Distribution Width Normal" ; a owl:Class ; rdfs:label "Normal Red Blood Cell Distribution Width" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000829 obo:IAO_0000115 "When the level of serum creatinine is in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal Serum Creatinine Level", "Serum Creatinine Level Normal", "Serum Creatinine Normal" ; a owl:Class ; rdfs:label "Normal Serum Creatinine" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000830 obo:IAO_0000115 "When the level of serum alanine aminotransferase is in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "ALT Level Normal", "ALT Normal", "Normal ALT", "Normal ALT Level", "Normal Alanine Aminotransferase Level", "Normal Alanine Transaminase", "Normal Serum Alanine Aminotransferase Level", "Serum Alanine Aminotransferase Level Normal", "Serum Alanine Aminotransferase Normal" ; a owl:Class ; rdfs:label "Normal Serum Alanine Aminotransferase" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000831 obo:IAO_0000115 "When the level of serum aspartate aminotransferase is in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "AST Level Normal", "AST Normal", "Normal AST", "Normal AST Level", "Normal Aspartate Aminotransferase", "Normal Serum AST", "Normal Serum Aspartate Aminotransferase Level", "Serum AST Normal", "Serum Aspartate Aminotransferase Normal" ; a owl:Class ; rdfs:label "Normal Serum Aspartate Aminotransferase" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000832 obo:IAO_0000115 "When the level of serum alkaline aminotransferase is in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "AP Level Normal", "AP Normal", "Alkaline Phosphatase Level Normal", "Alkaline Phosphatase Normal", "Normal AP", "Normal AP Level", "Normal Serum AP Level", "Normal Serum Alkaline Phosphatase Level" ; a owl:Class ; rdfs:label "Normal Serum Alkaline Phosphatase" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000833 obo:IAO_0000115 "When the level of the enzyme lactate dehydrogenase in the serum is in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "LD Level Normal", "LD Normal", "LDH Level Normal", "LDH Normal", "Lactate Dehydrogenase Level Normal", "Lactate Dehydrogenase Normal", "Normal LD", "Normal LD Level", "Normal LDH", "Normal LDH Level" ; a owl:Class ; rdfs:label "Normal Lactate Dehydrogenase Level" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000834 obo:IAO_0000115 "When the number of reticulocytes in a specified volume of blood falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Reticulocyte Count Normal" ; a owl:Class ; rdfs:label "Normal Reticulocyte Count" ; rdfs:subClassOf obo:SCDO_1000821 . obo:SCDO_1000835 obo:IAO_0000115 "When the total bilirubin level in the serum is in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Serum Bilirubin Total Normal", "Total Serum Bilirubin Level Normal", "Total Serum Bilirubin Normal" ; a owl:Class ; rdfs:label "Normal Total Serum Bilirubin" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000836 obo:IAO_0000115 "When the concentration of urinary albumin falls in the normal range." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal Urinary Albumin Concentration", "Urinary Albumin Concentration Normal", "Urine Albumin Concentration Normal" ; a owl:Class ; rdfs:label "Normal Urine Albumin Concentration" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000837 obo:IAO_0000115 "When the concentration of urine creatinine falls in the normal range." ; obo:SCDO_1000288 "Few but definitions not available" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Creatinine Urine Normal", "Normal Urinary Creatinine", "Normal Urinary Creatinine Level", "Normal Urine Creatinine", "Urinary Creatinine Level Normal", "Urine Creatinine Level Normal" ; a owl:Class ; rdfs:label "Normal Urine Creatinine Level" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000838 obo:IAO_0000115 "When the pressure exerted by oxygen dissolved in the blood falls in the normal range." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal Oxygen Tension", "Normal PO2", "Normal PaO2", "Normal Partial Pressure of Blood Oxygen", "PO2 Normal", "PaO2 Normal", "Partial Pressure of Blood Oxygen Normal", "Partial Pressure of Oxygen Normal" ; a owl:Class ; rdfs:label "Normal Partial Pressure of Oxygen" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000839 obo:IAO_0000115 "When the pressure exerted by carbon dioxide dissolved in the blood falls in the normal range." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Normal Carbon Dioxide Tension", "Normal PaCO2", "Normal Partial Pressure of Blood Carbon Dioxide", "PaCO2 Normal", "Partial Pressure of Blood Carbon Dioxide Normal", "Partial Pressure of Carbon Dioxide Normal" ; a owl:Class ; rdfs:label "Normal Partial Pressure of Carbon Dioxide" ; rdfs:subClassOf obo:SCDO_1000812 . obo:SCDO_1000840 obo:IAO_0000115 "An abnormal reduction in the pressure exerted by carbon dioxide dissolved in the blood." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Decreased PCO2", "Decreased PaCO2", "Decreased Partial Pressure of Blood Carbon Dioxide", "PCO2 Decreased", "PaCO2 Decreased", "Partial Pressure of Blood Carbon Dioxide Decreased" ; a owl:Class ; rdfs:label "Decreased Partial Pressure of Carbon Dioxide" ; rdfs:subClassOf obo:MP_0002329 . obo:SCDO_1000841 obo:IAO_0000115 "An abnormal increase in the pressure exerted by carbon dioxide dissolved in the blood." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Elevated Partial Pressure of Carbon Dioxide", "Increased PCO2", "Increased PaCO2", "Increased Partial Pressure of Blood Carbon Dioxide", "PCO2 Increased", "PaCO2 Increased", "Partial Pressure of Carbon Dioxide Increased", "Raised Partial Pressure of Carbon Dioxide" ; a owl:Class ; rdfs:label "Increased Partial Pressure of Carbon Dioxide" ; rdfs:subClassOf obo:MP_0002329 . obo:SCDO_1000842 obo:IAO_0000115 "Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000842" ; oboInOwl:hasDbXref "MESH:D016857" ; oboInOwl:hasExactSynonym "Hypocarbia" ; a owl:Class ; rdfs:label "Hypocapnia" ; rdfs:subClassOf obo:MP_0002329 . obo:SCDO_1000843 obo:IAO_0000115 "A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000843" ; oboInOwl:hasDbXref "MESH:D006935" ; oboInOwl:hasExactSynonym "Hypercarbia" ; a owl:Class ; rdfs:label "Hypercapnia" ; rdfs:subClassOf obo:MP_0002329 . obo:SCDO_1000844 obo:IAO_0000115 "When the abnormal hemoglobin, hemoglobin S (HbS), has been detected in a blood sample." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Haemoglobin S Present", "Haemoglobin S in Blood", "HbS Present", "HbS in Blood", "Hemoglobin S in Blood" ; a owl:Class ; rdfs:label "Hemoglobin S Present" ; rdfs:subClassOf obo:HP_0020061 . obo:SCDO_1000845 obo:IAO_0000115 "An indication of whether or not a data element with a dropdown field should be autocompleted. Annotation is either \"yes\" or \"no\"." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:label "autocomplete" . obo:SCDO_1000846 obo:IAO_0000115 "An indication of whether or not a data element with a slider field should display the slider's number values. Annotation is either \"yes\" or \"no\"." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:label "show slider" . obo:SCDO_1000847 obo:IAO_0000115 "The Sickle in Africa core data element that records the type of visit undertaken by a patient." ; obo:SCDO_1000517 """1, Routine 2, Acute 3, Review 4, First visit""" ; obo:SCDO_1000518 "Type of visit" ; obo:SCDO_1000519 "visit_type" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 2 ; obo:SCDO_1000749 "dropdown" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Type of Visit Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000496 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:EUPATH_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000849 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000900 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:SCDO_1000901 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C103165 ] . obo:SCDO_1000849 obo:IAO_0000115 "A clinical visit occuring because of an acute (severe with sudden onset) health condition." ; obo:SCDO_1000288 "Few but definitions not specific enough" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Acute Clinical Visit" ; rdfs:subClassOf obo:NCIT_C103165 . obo:SCDO_1000850 obo:IAO_0000115 "The Sickle in Africa core data element that records the patient's medical record number." ; obo:SCDO_1000518 "Medical record number (MRN)" ; obo:SCDO_1000519 "medical_record_number" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 4 ; obo:SCDO_1000749 "text" ; oboInOwl:hasExactSynonym "MRN", "Medical record number" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Medical Record Number Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C81262 ] . obo:SCDO_1000854 obo:IAO_0000115 "The Sickle in Africa core data element that records the name of the hospital that a patient visited." ; obo:SCDO_1000518 "Hospital name" ; obo:SCDO_1000519 "hospital_name" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 5 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Hospital Name Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000855 ] . obo:SCDO_1000855 obo:IAO_0000115 "The name of the hospital visited by a patient." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Hospital Name" ; rdfs:subClassOf obo:EUPATH_0000310 . obo:SCDO_1000856 obo:IAO_0000115 "The Sickle in Africa core data element that records a respondent's first name." ; obo:SCDO_1000518 "First name" ; obo:SCDO_1000519 "first_name" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 6 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - First Name Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000858 ] . obo:SCDO_1000857 obo:IAO_0000115 "The Sickle in Africa core data element that records a respondent's middle name." ; obo:SCDO_1000518 "Middle name" ; obo:SCDO_1000519 "middle_name" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 7 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Middle Name Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000860 ] . obo:SCDO_1000858 obo:IAO_0000115 "A first name is a name that denotes a specific individual between members of a group of individuals, whose members usually share the same surname." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000858" ; oboInOwl:hasDbXref "sio:FirstName" ; oboInOwl:hasExactSynonym "Forename", "Given Name" ; a owl:Class ; rdfs:label "First Name" ; rdfs:subClassOf obo:NCIT_C25191 . obo:SCDO_1000860 obo:IAO_0000115 "A middle name is a name assigned to an individual that is not the first or last name." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000860" ; oboInOwl:hasDbXref "sio:MiddleName" ; a owl:Class ; rdfs:label "Middle Name" ; rdfs:subClassOf obo:NCIT_C25191 . obo:SCDO_1000861 obo:IAO_0000115 "A last name (surname) is a name added to a given name and is part of a personal name and is often the family name." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000861" ; oboInOwl:hasDbXref "sio:LastName" ; a owl:Class ; rdfs:label "Last Name" ; rdfs:subClassOf obo:NCIT_C25191 . obo:SCDO_1000862 obo:IAO_0000115 "The Sickle in Africa core data element that records a respondent's last name." ; obo:SCDO_1000518 "Last name" ; obo:SCDO_1000519 "last_name" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 8 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Last Name Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000861 ] . obo:SCDO_1000863 obo:IAO_0000115 "The Sickle in Africa core data element that records a respondent's height." ; obo:SCDO_1000518 "Height/Length" ; obo:SCDO_1000519 "height_length" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000737 "cm" ; obo:SCDO_1000739 12 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Height Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000015 ] . obo:SCDO_1000866 obo:IAO_0000115 "The Sickle in Africa core data element that records a respondent's measured weight." ; obo:SCDO_1000518 "Weight" ; obo:SCDO_1000519 "weight" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000737 "kg" ; obo:SCDO_1000739 13 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Weight Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000727 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000009 ] . obo:SCDO_1000868 obo:IAO_0000115 "The Sickle in Africa core data element that records the ethnic group to which a respondent belongs." ; obo:SCDO_1000518 "Ethnic Group" ; obo:SCDO_1000519 "tribe" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 16 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Ethnic Group Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C16564 ] . obo:SCDO_1000869 obo:IAO_0000115 "The Sickle in Africa core data element that records the religion of a respondent." ; obo:SCDO_1000518 "Religion" ; obo:SCDO_1000519 "religion" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 17 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Religion Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000981 ] . obo:SCDO_1000870 obo:IAO_0000115 "The Sickle in Africa core data element that records the region in which the respondent lives." ; obo:SCDO_1000518 "Region" ; obo:SCDO_1000519 "region" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 18 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Region Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C16632 ] . obo:SCDO_1000871 obo:IAO_0000115 "A street name is the token given to identify a particular street." ; obo:SCDO_0000340 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000871" ; oboInOwl:hasDbXref "SIO:000766" ; a owl:Class ; rdfs:label "Street Name" ; rdfs:subClassOf obo:NCIT_C19332 . obo:SCDO_1000872 obo:IAO_0000115 "The Sickle in Africa core data element that records the name of the street in which the respondent lives." ; obo:SCDO_1000518 "Street" ; obo:SCDO_1000519 "street" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 19 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Street Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000871 ] . obo:SCDO_1000873 obo:IAO_0000115 "The Sickle in Africa core data element that records the landmark that is nearest to where the participant lives." ; obo:SCDO_1000518 "Nearest landmark" ; obo:SCDO_1000519 "nearest_landmark" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 20 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Nearest Landmark Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000874 ] . obo:SCDO_1000874 obo:IAO_0000115 "A recognizable natural or artificial geographic feature, used for navigation (often visible from long distances), that is nearest to where the participant lives." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Nearest Geographical Landmark" ; rdfs:subClassOf obo:NCIT_C19332 . obo:SCDO_1000875 obo:IAO_0000115 "The name of a respondent's next of kin." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Next of Kin Name" ; rdfs:subClassOf obo:NCIT_C25191 . obo:SCDO_1000876 obo:IAO_0000115 "The Sickle in Africa core data element that records the participant's primary telephone number." ; obo:SCDO_1000518 "Telephone 1" ; obo:SCDO_1000519 "telephone_1" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 21 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Telephone 1 Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000882 ] . obo:SCDO_1000877 obo:IAO_0000115 "The Sickle in Africa core data element that records the participant's secondary telephone number." ; obo:SCDO_1000518 "Telephone 2" ; obo:SCDO_1000519 "telephone_2" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 22 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Telephone 2 Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000883 ] . obo:SCDO_1000878 obo:IAO_0000115 "The Sickle in Africa core data element that records the name of the participant's next of kin." ; obo:SCDO_1000518 "Next of kin name" ; obo:SCDO_1000519 "next_of_kin_name" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 23 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Next of Kin Name Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000875 ] . obo:SCDO_1000879 obo:IAO_0000115 "The Sickle in Africa core data element that records the telephone number of the participant's next of kin." ; obo:SCDO_1000518 "Next of kin telephone number" ; obo:SCDO_1000519 "next_of_kin_telephone_numb" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 24 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Next of Kin Number Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000884 ] . obo:SCDO_1000880 obo:IAO_0000115 "The Sickle in Africa core data element that records the participant's next of kin's relationship to the participant." ; obo:SCDO_1000518 "Relationship to participant" ; obo:SCDO_1000519 "next_of_kin_relationship" ; obo:SCDO_1000735 "Demographics" ; obo:SCDO_1000739 25 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Relationship to Participant Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000502 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000885 ] . obo:SCDO_1000882 obo:IAO_0000115 "A respondent's primary telephone number." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Telephone Number 1" ; rdfs:subClassOf obo:NCIT_C40978 . obo:SCDO_1000883 obo:IAO_0000115 "A respondent's secondary telephone number." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Telephone Number 2" ; rdfs:subClassOf obo:NCIT_C40978 . obo:SCDO_1000884 obo:IAO_0000115 "The telephone number of a respondent's next of kin." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Next of Kin Telephone Number" ; rdfs:subClassOf obo:NCIT_C40978 . obo:SCDO_1000885 obo:IAO_0000115 "The relationship that the participant's next of kin has with the participant." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Next of Kin Relationship to Patient" ; a owl:Class ; rdfs:label "Next of Kin Relationship to Participant" ; rdfs:subClassOf obo:NCIT_C19332 . obo:SCDO_1000886 obo:IAO_0000115 "The Sickle in Africa core data element that records whether the participant was given a blood transfusion." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Blood transfusion" ; obo:SCDO_1000519 "blood_transfusion" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 7 ; obo:SCDO_1000749 "yesno" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Blood Transfusion Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000534 ] . obo:SCDO_1000887 obo:IAO_0000115 "The Sickle in Africa core data element that records the number of units of blood that a participant was given during a blood transfusion." ; obo:SCDO_1000518 "Units transfused" ; obo:SCDO_1000519 "units_transfused" ; obo:SCDO_1000735 "Management Details" ; obo:SCDO_1000739 9 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000742 "[blood_transfusion] = \"Yes\"" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Units Transfused Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_1000888 ] . obo:SCDO_1000888 obo:IAO_0000115 "The number of units of blood that a patient received during a blood transfusion." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "Number of Units Transfused" ; rdfs:subClassOf obo:SCDO_1000590 . obo:SCDO_1000889 obo:IAO_0000115 "The Sickle in Africa core data element that records whether a participant has difficulty in breathing." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Difficulty in breathing" ; obo:SCDO_1000519 "difficulty_in_breathing" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000739 4 ; obo:SCDO_1000749 "yesno" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Difficulty in Breathing Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:HP_0002098 ] . obo:SCDO_1000890 obo:IAO_0000115 "The Sickle in Africa core data element that records a participant's systolic blood pressure." ; obo:SCDO_1000518 "Systolic blood pressure" ; obo:SCDO_1000519 "systolic_blood_press" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000737 "mmHg" ; obo:SCDO_1000739 5 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Systolic Blood Pressure Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C25298 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000272 ] . obo:SCDO_1000891 obo:IAO_0000115 "The Sickle in Africa core data element that records a participant's diastolic blood pressure." ; obo:SCDO_1000518 "Diastolic blood pressure" ; obo:SCDO_1000519 "diastol_blood_press" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000737 "mmHg" ; obo:SCDO_1000739 6 ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Diastolic Blood Pressure Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:NCIT_C25299 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:UO_0000272 ] . obo:SCDO_1000894 obo:IAO_0000115 "The Sickle in Africa core data element that records whether a participant has priapism." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Priapism" ; obo:SCDO_1000519 "priapism" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000739 7 ; obo:SCDO_1000749 "yesno" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Priapism Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:SCDO_0000923 ] . obo:SCDO_1000895 obo:IAO_0000115 "The Sickle in Africa core data element that records whether a participant has chest pain." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Chest Pain" ; obo:SCDO_1000519 "chest_pain" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000739 8 ; obo:SCDO_1000749 "yesno" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Chest Pain Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:HP_0100749 ] . obo:SCDO_1000896 obo:IAO_0000115 "The Sickle in Africa core data element that records whether a participant has anaemia." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Anaemia" ; obo:SCDO_1000519 "anaemia" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000739 9 ; obo:SCDO_1000749 "yesno" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Anaemia Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:HP_0001903 ] . obo:SCDO_1000897 obo:IAO_0000115 "The Sickle in Africa core data element that records whether a participant has jaundice." ; obo:SCDO_1000517 """1, Yes 0, No""" ; obo:SCDO_1000518 "Jaundice" ; obo:SCDO_1000519 "jaundice" ; obo:SCDO_1000735 "Vital Signs" ; obo:SCDO_1000739 10 ; obo:SCDO_1000749 "yesno" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Jaundice Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000498 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000023 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000526 ; owl:someValuesFrom obo:OPMI_0000024 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:HP_0000952 ] . obo:SCDO_1000898 obo:IAO_0000115 "The Sickle in Africa core data element that collects the concentration of urea in the respondent's blood." ; obo:SCDO_1000518 "Urea" ; obo:SCDO_1000519 "urea" ; obo:SCDO_1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" ; obo:SCDO_1000737 "mmol/L" ; obo:SCDO_1000739 2 ; obo:SCDO_1000741 "Number" ; obo:SCDO_1000749 "text" ; a owl:Class ; rdfs:label "SickleInAfrica CDE - Urea Question" ; rdfs:subClassOf obo:SCDO_1000509, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000525 ; owl:someValuesFrom obo:SCDO_1000501 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000528 ; owl:someValuesFrom obo:EUPATH_0021227 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000771 ; owl:someValuesFrom obo:NCIT_C64387 ] . obo:SCDO_1000900 obo:IAO_0000115 "A clinical visit that is the patient's first clinical visit." ; obo:SCDO_1000288 "None" ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:Class ; rdfs:label "First Visit" ; rdfs:subClassOf obo:NCIT_C103165 . obo:SCDO_1000901 obo:IAO_0000115 "A clinical visit that is a follow-up for a previous visit." ; obo:SCDO_1000288 "Not relevant to context of sickle cell" ; dc:creator "SCDO (Jade Hotchkiss)" ; oboInOwl:hasExactSynonym "Review Visit" ; a owl:Class ; rdfs:label "Follow-Up Visit" ; rdfs:subClassOf obo:NCIT_C103165 . obo:SCDO_1000910 obo:IAO_0000115 "Used to record the identifier that had been used previously but is no longer in use." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:AnnotationProperty ; rdfs:label "previous identifier" . obo:SCDO_1110663 obo:IAO_0000115 "A relation between an entity (phenotypic, therapeutic or diagnostic concept) and a guideline or directive." ; dc:creator "SCDO (Jade Hotchkiss)" ; a owl:ObjectProperty ; rdfs:label "in guideline" . obo:STATO_0000091 obo:IAO_0000115 "Genome wide association study is a kind of study whose objective is to detect association between genetic markers (SNP or otherwise) accross the genome and a trait which may be a disease or another phenotype (e.g. trait of agronomic relevance in animal or plant studies). Genome wide association study compare the allele frequencies in 2 populations, one free of the trait used as control, the other one showing the trait use as 'case'. GWAS studies implement case-control design." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/STATO_0000091" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000450" ; oboInOwl:hasDbXref "STATO:0000091" ; oboInOwl:hasExactSynonym "GWAS" ; a owl:Class ; rdfs:label "Genome Wide Association Study" ; rdfs:subClassOf obo:SCDO_0000437 . obo:SYMP_0000412 obo:IAO_0000115 "A neurological and physiological symptom characterized by a painful or apprehensive uneasiness of mind usually over an impending or anticipated ill." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/SYMP_0000412" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000068" ; dc:source "http://www.apa.org/topics/anxiety/" ; oboInOwl:hasDbXref "SYMP:0000412" ; oboInOwl:hasExactSynonym "Anxiety Symptoms", "Panic", "Worry" ; a owl:Class ; rdfs:comment "Physical symptoms include increased blood pressure (rapid heartbeat), trembling or dizziness." ; rdfs:label "Anxiety" ; rdfs:subClassOf obo:HP_0000708, obo:SCDO_0000746, obo:SCDO_0000954, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:SYMP_0019161 obo:IAO_0000115 "Muscle pain is a pain characterized by pain in one or more muscles." ; obo:SCDO_0000303 "Provide source for additional info" ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/SYMP_0019161" ; obo:SCDO_0000661 "Over-stretching of one muscle or a group of muscles, trauma, infections ( influenza, Lyme, Ebola, Dengue fever, Chicungunya fever, Babesiosis, Malaria, Toxoplasmosis, Hemorrhage fever, polio, Rocky Mountain spotted fever, Trichinosis), vaccines, muscle hematoma, autoimmune disorders ( lupus, polymyalgia, polymyositis, nutricional deficiencies, chronic fatigue syndrome, acute rejection after heart transplant surgery, rhabdomyolysis, severe potassium deficiency, fibromialgia, muscle abscess , reaction to drugs ( statins, fibrates, ACE inhibitors, cocaine), repetitive strain injury,withdrawal syndrome of certain drugs ( corticosteroids, opioids, barbiturates, benzodiazepines, caffeine, alcohol)." ; obo:SCDO_0000662 "Pain of a muscle or a group of muscles." ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000779" ; oboInOwl:hasDbXref "SYMP:0019161" ; oboInOwl:hasExactSynonym "Myalgia" ; a owl:Class ; rdfs:label "Muscle Pain" ; rdfs:subClassOf obo:SCDO_0000851, [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000050 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000057 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_0000262 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_0000664 ; owl:someValuesFrom obo:SCDO_1000020 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ] . obo:UO_0000000 obo:IAO_0000115 "A standardized quantity of a physical quality." ; obo:SCDO_0000340 obo:UO_0000000 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000478" ; oboInOwl:hasDbXref "UO:0000000" ; oboInOwl:hasExactSynonym "Unit", "Unit of Measure", "Units" ; a owl:Class ; rdfs:label "Unit of Measurement" ; rdfs:subClassOf obo:SCDO_1000472 . obo:UO_0000001 obo:IAO_0000115 "A unit which is a standard measure of the distance between two points." ; obo:SCDO_0000340 obo:UO_0000001 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000864" ; oboInOwl:hasDbXref "UO:0000001" ; a owl:Class ; rdfs:label "Length Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000002 obo:IAO_0000115 "A unit which is a standard measure of the amount of matter/energy of a physical object." ; obo:SCDO_0000340 obo:UO_0000002 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000628" ; oboInOwl:hasDbXref "UO:0000002" ; a owl:Class ; rdfs:label "Mass Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000005 obo:IAO_0000115 "A unit which is a standard measure of the average kinetic energy of the particles in a sample of matter." ; obo:SCDO_0000340 obo:UO_0000005 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000712" ; oboInOwl:hasDbXref "UO:0000005" ; a owl:Class ; rdfs:label "Temperature Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000009 obo:IAO_0000115 "A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France." ; obo:SCDO_0000340 obo:UO_0000009 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000867" ; oboInOwl:hasDbXref "UO:0000009" ; a owl:Class ; rdfs:label "Kilogram" ; rdfs:subClassOf obo:UO_0000002 . obo:UO_0000015 obo:IAO_0000115 "A length unit which is equal to one hundredth of a meter or 10^[-2] m." ; obo:SCDO_0000340 obo:UO_0000015 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000865" ; oboInOwl:hasDbXref "UO:0000015" ; a owl:Class ; rdfs:label "Centimeter" ; rdfs:subClassOf obo:UO_0000001 . obo:UO_0000025 obo:IAO_0000115 "A mass unit which is equal to 10^[-12] g." ; obo:SCDO_0000340 obo:UO_0000025 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000629" ; oboInOwl:hasDbXref "UO:0000025" ; oboInOwl:hasExactSynonym "picogram" ; a owl:Class ; rdfs:label "pg" ; rdfs:subClassOf obo:UO_0000002 . obo:UO_0000051 obo:IAO_0000115 "A unit which represents a standard measurement of how much of a given substance there is mixed with another substance." ; obo:SCDO_0000340 obo:UO_0000051 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000491" ; oboInOwl:hasDbXref "UO:0000051" ; a owl:Class ; rdfs:label "Concentration Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000095 obo:IAO_0000115 "A unit which is a standard measure of the amount of space occupied by any substance, whether solid, liquid, or gas." ; obo:SCDO_0000340 obo:UO_0000095 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000622" ; oboInOwl:hasDbXref "UO:0000095" ; a owl:Class ; rdfs:label "Volume Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000104 obo:IAO_0000115 "A volume unit which is equal to 10^[-15] L." ; obo:SCDO_0000340 obo:UO_0000104 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000623" ; oboInOwl:hasDbXref "UO:0000104" ; oboInOwl:hasExactSynonym "cubic micrometre", "femtoliter", "femtolitre", "μm^3" ; a owl:Class ; rdfs:label "fL" ; rdfs:subClassOf obo:UO_0000095 . obo:UO_0000109 obo:IAO_0000115 "A unit which is a standard measure of the force applied to a given area." ; obo:SCDO_0000340 obo:UO_0000109 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000720" ; oboInOwl:hasDbXref "UO:0000109" ; a owl:Class ; rdfs:label "Pressure Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000180 obo:IAO_0000115 "A concentration unit which is a standard measure of the mass of a substance in a given volume (density)." ; obo:SCDO_0000340 obo:UO_0000180 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000506" ; oboInOwl:hasDbXref "UO:0000180" ; oboInOwl:hasExactSynonym "Unit of Density" ; a owl:Class ; rdfs:comment "Definition from BioAssay Ontology" ; rdfs:label "Mass Per Unit Volume" ; rdfs:subClassOf obo:UO_0000051 . obo:UO_0000186 obo:IAO_0000115 "A unit which is a standard measure of physical quantity consisting of only a numerical number without any units." ; obo:SCDO_0000340 obo:UO_0000186 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000642" ; oboInOwl:hasDbXref "UO:0000186" ; a owl:Class ; rdfs:label "Dimensionless Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000187 obo:IAO_0000115 "A dimensionless ratio unit which denotes numbers as fractions of 100." ; obo:SCDO_0000340 obo:UO_0000187 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000644" ; oboInOwl:hasDbXref "UO:0000187" ; oboInOwl:hasExactSynonym "%" ; a owl:Class ; rdfs:label "Percent" ; rdfs:subClassOf obo:UO_0000190 . obo:UO_0000190 obo:IAO_0000115 "A dimensionless unit which denotes an amount or magnitude of one quantity relative to another." ; obo:SCDO_0000340 obo:UO_0000190 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000643" ; oboInOwl:hasDbXref "UO:0000190" ; a owl:Class ; rdfs:label "Ratio" ; rdfs:subClassOf obo:UO_0000186 . obo:UO_0000200 obo:IAO_0000115 "A concentration unit which denotes the average cell number in a given volume." ; obo:SCDO_0000340 obo:UO_0000200 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000503" ; oboInOwl:hasDbXref "UO:0000200" ; a owl:Class ; rdfs:label "Cell Concentration Unit" ; rdfs:subClassOf obo:UO_0000051 . obo:UO_0000272 obo:IAO_0000115 "A unit of pressure equal to the amount of fluid pressure one millimeter deep in mercury at zero degrees centigrade on Earth." ; obo:SCDO_0000340 obo:UO_0000272 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000721" ; oboInOwl:hasDbXref "UO:0000272" ; oboInOwl:hasExactSynonym "millimetres of mercury" ; a owl:Class ; rdfs:label "mmHg" ; rdfs:subClassOf obo:UO_0000109 . obo:UO_0000280 obo:IAO_0000115 "A unit which represents a standard measurement occurrence of a process per unit time." ; obo:SCDO_0000340 obo:UO_0000280 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000715" ; oboInOwl:hasDbXref "UO:0000280" ; a owl:Class ; rdfs:label "Rate Unit" ; rdfs:subClassOf obo:UO_0000000 . obo:UO_0000316 obo:IAO_0000115 "A unit of cell concentration which is equal to one cell in a volume of 1 microliter." ; obo:SCDO_0000340 obo:UO_0000316 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000507" ; oboInOwl:hasDbXref "UO:0000316" ; oboInOwl:hasExactSynonym "cells per microliter", "cells/µL" ; a owl:Class ; rdfs:label "cells per microliter" ; rdfs:subClassOf obo:UO_0000200 . obo:VO_0000001 obo:IAO_0000115 "A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/VO_0000001" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001221" ; oboInOwl:hasDbXref "VO:0000001" ; a owl:Class ; rdfs:label "Vaccine" ; rdfs:subClassOf obo:SCDO_0000930, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000144 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000145 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000146 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000147 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000148 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000151 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000152 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:VO_0000642 obo:IAO_0000115 "A viral vaccine that protects against infection with influenza virus." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/VO_0000642" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0000642" ; oboInOwl:hasDbXref "VO:0000642" ; a owl:Class ; rdfs:label "Influenza Virus Vaccine" ; rdfs:subClassOf obo:VO_0000001, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ] . obo:VO_0000675 obo:IAO_0000115 "A Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases." ; obo:SCDO_0000340 "http://purl.obolibrary.org/obo/VO_0000675" ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:0001109" ; oboInOwl:hasDbXref "VO:0000675" ; oboInOwl:hasExactSynonym "Pneumococcal Vaccine" ; a owl:Class ; rdfs:label "Streptococcus Pneumoniae Vaccine" ; rdfs:subClassOf obo:VO_0000001, [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000149 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000150 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1110663 ; owl:someValuesFrom obo:SCDO_1000154 ] . obo:VT_0000202 obo:IAO_0000115 "The amount of alkaline phosphatase present in a specified volume of blood.", "The proportion, quantity, or volume in whole blood, serum, or plasma of this enzyme, which hydrolyzes orthophosphoric monoesters." ; obo:SCDO_0000340 obo:VT_0000202 ; obo:SCDO_1000288 "Sufficient" ; obo:SCDO_1000910 "SCDO:1000499" ; oboInOwl:hasDbXref "VT:0000202" ; oboInOwl:hasExactSynonym "AP Level", "Blood Alkaline Phosphatase Amount", "Circulating ALP Level", "Circulating Alkaline Phosphatase Level" ; a owl:Class ; rdfs:label "Alkaline Phosphatase Level" ; rdfs:subClassOf obo:CMO_0000023, [ a owl:Restriction ; owl:onProperty obo:SCDO_1000190 ; owl:someValuesFrom obo:SCDO_1000663 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0003155 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:HP_0003282 ], [ a owl:Restriction ; owl:onProperty obo:SCDO_1000772 ; owl:someValuesFrom obo:SCDO_1000832 ] . hp1:abbreviation obo:IAO_0000115 "A shortened form of a word or phrase, in this case a class/term. It consists of a group of letters taken from the word or phrase." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "yes" ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; a owl:AnnotationProperty ; rdfs:label "abbreviation" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp1:obsolete_synonym a owl:AnnotationProperty ; rdfs:label "discarded/obsoleted synonym" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp1:plural_form a owl:AnnotationProperty ; rdfs:label "plural form" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . hp:layperson a owl:AnnotationProperty ; rdfs:label "layperson term" ; rdfs:subPropertyOf oboInOwl:SynonymTypeProperty . dc:LicenseDocument ; dc:abstract "Sickle cell disease (SCD) is one of the most common monogenic diseases in humans with multiple phenotypic expressions that can manifest as both acute and chronic complications. Although described more than a century ago, challenges in comprehensive disease management and collaborative research on this disease are compounded by the complex molecular and clinical phenotypes of SCD, environmental and psychosocial factors, limited therapeutic options and ambiguous terminology. This ambiguous terminology has hampered the integration and interoperability of existing SCD knowledge, and SCD research translation. The SCD Ontology (SCDO), which is a community-driven integrative and universal knowledge representation system for SCD, overcomes this issue by providing a controlled vocabulary developed by a group of experts in both SCD and ontology design. SCDO is the first and most comprehensive standardized human- and machine-readable resource that unambiguously represents terminology and concepts about SCD for researchers, patients and clinicians. It is built around the central concept ‘hemoglobinopathy’, allowing inclusion of non-SCD haemoglobinopathies, such as thalassaemias, which may interfere with or influence SCD phenotypic manifestations. This collaboratively developed ontology constitutes a comprehensive knowledge management system and standardized terminology of various SCD-related factors. The SCDO will promote interoperability of different research datasets, facilitate seamless data sharing and collaborations, including meta-analyses within the SCD community, and support the development and curation of data-basing and clinical informatics in SCD." ; dc:accessRights "Anyone can access the resource." ; dc:accrualMethod "Manually, based on terms in existing ontologies and in collaboration with sickle cell disease (SCD) experts where necessary." ; dc:accrualPeriodicity "As necessary. Not currently following a fixed frequency." ; dc:accrualPolicy "Terms/classes are added as they are identified as necessary by the sickle cell disease (SCD) community." ; dc:audience "Researchers in Hemoglobinopathy and/or sickle cell disease (SCD), SCD patients and clinicians." ; dc:available "First draft was made available in BioPortal in May 2017" ; dc:conformsTo "OBO Foundry standards." ; dc:coverage "The field of sickle cell disease (SCD) research and care." ; dc:isReferencedBy , , , ; dc:issued "April 2021" ; dc:language "English" ; dc:license "GPL-3.0" ; a owl:Ontology ; owl:versionIRI . obo:SCDO_0000340 ; oboInOwl:hasDbXref "so:associated_with" ; a owl:ObjectProperty ; rdfs:label "associated with" ; rdfs:subPropertyOf owl:topObjectProperty . dc:LicenseDocument obo:IAO_0000115 "A legal document giving official permission to do something with a Resource." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:LicenseDocument" ; skos:prefLabel "License Document" . dc:abstract obo:IAO_0000115 "A summary of the resource." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:abstract" ; skos:prefLabel "Abstract" . dc:accessRights obo:IAO_0000115 "Information about who can access the resource or an indication of its security status." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:accessRights" ; skos:prefLabel "Access Rights" . dc:accrualMethod obo:IAO_0000115 "The method by which items are added to a collection." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:accrualMethod" ; skos:prefLabel "Accrual Method" . dc:accrualPeriodicity obo:IAO_0000115 "The frequency with which items are added to a collection." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:accrualPeriodicity" ; skos:prefLabel "Accrual Periodicity" . dc:accrualPolicy obo:IAO_0000115 "The policy governing the addition of items to a collection." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:accrualPolicy" ; skos:prefLabel "Accrual Policy" . dc:audience obo:IAO_0000115 "A class of entity for whom the resource is intended or useful." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:audience" ; skos:prefLabel "Audience" . dc:available obo:IAO_0000115 "Date (often a range) that the resource became or will become available." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:available" ; skos:prefLabel "Date Available" . dc:conformsTo obo:IAO_0000115 "An established standard to which the described resource conforms." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:conformsTo" ; skos:prefLabel "Conforms To" . dc:coverage obo:IAO_0000115 "The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:coverage" ; skos:prefLabel "Coverage" . dc:creator obo:IAO_0000115 "An entity primarily responsible for making the resource. (This property is used in the SCDO when a term was created by the SCDO Working Group or a curator.) The SCDO uses this especially to apply to term descriptions." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ready for release" ; a owl:AnnotationProperty ; rdfs:label "dc:creator" ; skos:prefLabel "Creator" . dc:isReferencedBy obo:IAO_0000115 "A related resource that references, cites, or otherwise points to the described resource." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:isReferencedBy" ; skos:prefLabel "Is Referenced By" . dc:issued obo:IAO_0000115 "Date of formal issuance (e.g., publication) of the resource." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:issued" ; skos:prefLabel "Date Issued" . dc:language obo:IAO_0000115 "A language of the resource." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:comment "Recommended best practice is to use a controlled vocabulary such as RFC 4646 [RFC4646]." ; rdfs:label "dc:language" ; skos:prefLabel "Language" . dc:license obo:IAO_0000115 "A legal document giving official permission to do something with the resource." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "ontology annotation property" ; a owl:AnnotationProperty ; rdfs:label "dc:license" ; skos:prefLabel "License" . dc:source obo:IAO_0000115 "A related resource from which the described class/term's annotations are derived." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "yes" ; obo:SCDO_0000929 "pending vetting by the SCDO developers" ; a owl:AnnotationProperty ; rdfs:label "dc:source" . rdfs:label """Visit your GP if you or your child have unexplained symptomssuch as balance and co-ordination problems or difficulty walking, talking or swallowing. Family and medical history: Your GP may ask whether you have any family history of ataxia. They will also want to know about the progression of your symptoms. They might carry out a simple assessment of your balance, walking and co-ordination. Your GP may also ask how much alcohol you drink and whether you're taking any form of medication. This is because excessive drinking and certain medications can cause ataxia-like symptoms in some people. You may be referred for a series of tests to rule out other possible causes of your symptoms, such as an infection. The tests will probably include blood and urine tests. Further testing: If your symptoms suggest you may have acquired ataxia because of a serious underlying condition, it's likely you'll be admitted immediately to your nearest hospital. Otherwise, you'll be referred to a neurologist (a specialist in brain and nervous system conditions) for further testing or, in the case of children, a paediatrician. Some of the tests you may have are described below. Genetic testing: Genetic testing involves taking a sample of blood and testing the DNA in it for any genetic mutation known to cause ataxia.Currently, tests can detect the mutations responsible for Friedreich's ataxia, ataxia-telangiectasia and most of the spinocerebellar ataxias. Brain scans: Brain scans can be used to check for physical abnormalities in the brain that could be caused by certain types of hereditary ataxia. They can also be used to check for other problems that may affect your brain, such as a brain tumour. The two most widely used brain imaging scans are: magnetic resonance imaging (MRI) scan – this uses a strong magnetic field and radio waves to produce detailed scans of the soft tissue of the brain. computerised tomography (CT) scan – where a series of X-raysare taken and assembled by a computer into a detailed three-dimensional image of your brain Other tests: Some of the other tests you may have to help diagnose ataxia and determine how severe it is can include: a lumbar puncture – where a sample of cerebrospinal fluid is taken from the base of the spine to check it for infection and any other abnormalities. nerve conduction studies and electromyography (EMG) – tests used to assess the electrical activity in nerves and muscles. videofluoroscopy – a continuous moving X-ray taken while you swallow different types of food and drink. an electrocardiogram (ECG) – an assessment of the electrical activity of the heart. an echocardiogram – an ultrasound scan of the heart.""" . rdfs:label "Surgery" . rdfs:label """main treatments are lifestyle changes to ensure you remain as healthy as possible medication to control associated problems such as high blood pressure and high cholesterol dialysis – treatment to replicate some of the kidney's functions; this may be necessary in advanced CKD kidney transplant – this may also be necessary in advanced CKD""" . rdfs:label "Cancer can be caused by genetic factors; lifestyle factors such as tobacco use, diet, and physical activity; certain types of infections; and environmental exposures to different types of chemicals and radiation." . dc:source , ; rdfs:label "Severely Increased Albuminuria" . rdfs:label "Pulse Oximeter" . obo:IAO_0000115 "The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "no" ; oboInOwl:hasDbXref "D011877" ; rdfs:label "Scintigraphy" . rdfs:label """May be Acute (acute kidney injury) or chronic (see chronic kidney disease). """ . rdfs:label "Hair-pulling" . rdfs:label """Ddiagnosed by kidney biopsy - Diagnostic features include capillary wall thickening, normal cellularity, IgG and C3 along capillary walls on immunofluorescence, and subepithelial deposits on electron microscopy [KDIGO 2012].""" . rdfs:label """Main treatments are lifestyle changes to ensure you remain as healthy as possible medication to control associated problems such as high blood pressure and high cholesterol dialysis – treatment to replicate some of the kidney's functions; this may be necessary in advanced CKD kidney transplant – this may also be necessary in advanced CKD""" . rdfs:label """main treatments are: lifestyle changes to ensure you remain as healthy as possible medication to control associated problems such as high blood pressure and high cholesterol dialysis – treatment to replicate some of the kidney's functions; this may be necessary in advanced CKD kidney transplant – this may also be necessary in advanced CKD""" . rdfs:label "Hemoglobin M Disease" . rdfs:label "Pain Management" . rdfs:label "Biologic therapy, Antibody therapy, Stem-cell transplantation, Splenectomy, Steroid treatment, Radioimmunotherapy, Surgery, chemotherapy, and radiation therapy," . obo:IAO_0000115 "A list of essential measures, measures that are critical to the collection of the measure at hand or are necessary for the interpretation of results for the measure at hand. Without such information, the data collected would be incomplete or misleading." ; obo:SCDO_0000929 "example to be eventually removed" ; rdfs:label "essential measures (annotations)" . rdfs:label """Anti-inflammatory medications for joint pain and stiffness. Steroid creams for rashes. Corticosteroids to minimize the immune response. Antimalarial drugs for skin and joint problems. """ . obo:SCDO_0000340 ; rdfs:label "Test for Stroke Risk in Children with Sickle Cell Disease - TCD" . obo:IAO_0000115 "A measurement performed during physical examination to determine the size of the liver and identify possible hepatomegaly." ; obo:SCDO_0000340 ; obo:SCDO_0000363 "yes" ; obo:SCDO_0000929 "uncurated" ; rdfs:label "Assessment for Hepatomegaly" . rdfs:label "Test for Stroke Risk in Children with Sickle Cell Disease - TCDi" . rdfs:label "Peritonitis, intraabdominal abscess, or sepsis, necrotizing myometritis, necrotizing fasciitis of the abdominal wall, septic pelvic thrombophlebitis, and toxic shock syndrome are rare complications, death. Amy be associated to secondary infertility." . rdfs:label """Visit your GP if you or your child have unexplained symptomssuch as balance and co-ordination problems or difficulty walking, talking or swallowing. Family and medical history: Your GP may ask whether you have any family history of ataxia. They will also want to know about the progression of your symptoms. They might carry out a simple assessment of your balance, walking and co-ordination. Your GP may also ask how much alcohol you drink and whether you're taking any form of medication. This is because excessive drinking and certain medications can cause ataxia-like symptoms in some people. You may be referred for a series of tests to rule out other possible causes of your symptoms, such as an infection. The tests will probably include blood and urine tests. Further testing: If your symptoms suggest you may have acquired ataxia because of a serious underlying condition, it's likely you'll be admitted immediately to your nearest hospital. Otherwise, you'll be referred to a neurologist (a specialist in brain and nervous system conditions) for further testing or, in the case of children, a paediatrician. Some of the tests you may have are described below. Genetic testing: Genetic testing involves taking a sample of blood and testing the DNA in it for any genetic mutation known to cause ataxia. Currently, tests can detect the mutations responsible for Friedreich's ataxia, ataxia-telangiectasia and most of the spinocerebellar ataxias. Brain scans: Brain scans can be used to check for physical abnormalities in the brain that could be caused by certain types of hereditary ataxia. They can also be used to check for other problems that may affect your brain, such as a brain tumour. The two most widely used brain imaging scans are: magnetic resonance imaging (MRI) scan – this uses a strong magnetic field and radio waves to produce detailed scans of the soft tissue of the brain. computerised tomography (CT) scan – where a series of X-raysare taken and assembled by a computer into a detailed three-dimensional image of your brain Other tests: Some of the other tests you may have to help diagnose ataxia and determine how severe it is can include: a lumbar puncture – where a sample of cerebrospinal fluid is taken from the base of the spine to check it for infection and any other abnormalities. nerve conduction studies and electromyography (EMG) – tests used to assess the electrical activity in nerves and muscles. videofluoroscopy – a continuous moving X-ray taken while you swallow different types of food and drink. an electrocardiogram (ECG) – an assessment of the electrical activity of the heart. an echocardiogram – an ultrasound scan of the heart.""" . obo:IAO_0000115 "The branch of medicine that deals with the anatomy, functions and disorders of the nervous system." ; obo:SCDO_0000363 "no" ; dc:source ; oboInOwl:hasNarrowSynonym "Neurological disorders" ; rdfs:label "Neurology" . rdfs:label """Blood tests, such as antibody tests and a complete blood count, a urinalysis and a chest X-ray.""" . oboInOwl:SynonymTypeProperty a owl:AnnotationProperty ; rdfs:label "synonym_type_property" . oboInOwl:hasBroadSynonym obo:IAO_0000115 "An alias in which the alias is broader than the primary class name. Example: cell division is a broad synonym of cytokinesis." ; obo:SCDO_0000340 oboInOwl:hasBroadSynonym ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "pending vetting by the SCDO developers" ; a owl:AnnotationProperty ; rdfs:label "hasBroadSynonym" . oboInOwl:hasDbXref obo:IAO_0000115 "A database cross-reference. An annotation which directs one to information contained within a database." ; obo:SCDO_0000340 ; obo:SCDO_0000929 "metadata complete - requires restrictions and relationships" ; oboInOwl:hasDbXref "SBO:0000554" ; oboInOwl:hasExactSynonym "DbXref", "Xref", "database cross-reference", "database_cross_reference", "db xref", "hasDbXref" ; a owl:AnnotationProperty ; rdfs:label "database cross reference" . oboInOwl:hasExactSynonym obo:IAO_0000115 "An alias in which the alias exhibits true synonymy. Example: ornithine cycle is an exact synonym of urea cycle." ; obo:SCDO_0000340 oboInOwl:hasExactSynonym ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "pending vetting by the SCDO developers" ; a owl:AnnotationProperty ; rdfs:label "hasExactSynonym" . oboInOwl:hasNarrowSynonym obo:IAO_0000115 "An alias in which the alias is narrower than the primary class name. Example: pyrimidine-dimer repair by photolyase is a narrow synonym of photoreactive repair." ; obo:SCDO_0000340 oboInOwl:hasNarrowSynonym ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "pending vetting by the SCDO developers" ; a owl:AnnotationProperty ; rdfs:label "hasNarrowSynonym" . oboInOwl:hasRelatedSynonym obo:IAO_0000115 "An alias in which the alias is related to the primary class name, but not necessarily broader or narrower. Example: cytochrome bc1 complex is a related synonym of ubiquinol-cytochrome-c reductase activity; virulence is a related synonym of pathogenesis." ; obo:SCDO_0000340 oboInOwl:hasRelatedSynonym ; obo:SCDO_0000363 "no" ; obo:SCDO_0000929 "pending vetting by the SCDO developers" ; a owl:AnnotationProperty ; rdfs:label "hasRelatedSynonym" . oboInOwl:hasSynonymType obo:IAO_0000115 "An annotation property used to further annotate synonym axioms." ; a owl:AnnotationProperty ; rdfs:label "has_synonym_type" . rdfs:comment obo:IAO_0000115 "Additional information describing the class/term." ; obo:SCDO_0000340 rdfs:comment ; obo:SCDO_0000363 "yes" ; rdfs:label "rdfs:comment" . rdfs:label obo:IAO_0000115 "A human-readable name for the class/term." ; obo:SCDO_0000340 rdfs:label ; obo:SCDO_0000363 "yes" ; rdfs:label "rdfs:label" . rdfs:seeAlso obo:IAO_0000115 "Further information about the class/term." ; obo:SCDO_0000340 rdfs:seeAlso ; obo:SCDO_0000363 "yes" ; rdfs:label "rdfs:seeAlso" . owl:deprecated obo:IAO_0000115 "The annotation property that indicates that a given entity has been deprecated." ; rdfs:label "deprecated" . owl:topObjectProperty obo:SCDO_0000303 "Add properties that link diagnostic tools or measurements back to phenotypes...\"diagnoses\" when linked to a diagnosis? \"detects\" when linked to a phenotype that is a deviation from normal (e.g. an increased level of something)." . skos:prefLabel obo:IAO_0000115 "A preferred label." ; obo:SCDO_0000340 skos:prefLabel ; obo:SCDO_0000363 "yes" ; obo:SCDO_0000929 "pending vetting by the SCDO developers" ; a owl:AnnotationProperty ; rdfs:label "skos:prefLabel" . obo:SCDO_0000340 "PMID:22655528" . obo:SCDO_0000340 "PMID:6690472" . [] oboInOwl:SynonymTypeProperty hp1:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:SCDO_0000165 ; owl:annotatedTarget "BDR" . [] oboInOwl:SynonymTypeProperty hp1:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:SCDO_1000198 ; owl:annotatedTarget "NAT" . [] oboInOwl:hasSynonymType obo:SCDO_1000291 ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:HP_0030243 ; owl:annotatedTarget "Blood Clot in Liver Vein" . [] oboInOwl:SynonymTypeProperty hp1:abbreviation ; a owl:Axiom ; owl:annotatedProperty oboInOwl:hasExactSynonym ; owl:annotatedSource obo:NCIT_C114300 ; owl:annotatedTarget "COHb" .