made by pyLODE 2.10.0

TOXic Process Ontology (TXPO)

Metadata

URI
http://purl.obolibrary.org/obo/txpo.owl
Creator(s)
Yuki Yamagata yuki.yamagata at riken.jp
Version Information
2020/07/09
Version URI
http://purl.obolibrary.org/obo/txpo/releases/2020-03-03/txpo.owl
Ontology RDF
RDF (turtle)

Description

This ontology is beta version. We are currently refining annotations and expanding the theme of toxic courses.

Table of Contents

  1. Classes
  2. Object Properties
  3. Annotation Properties
  4. Namespaces
  5. Legend

Overview

Pictures say 1,000 words
Figure 1: Ontology overview

Classes ↑

OATP familyc # Classes

URI http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C107150
Description

A family of transmembrane proteins that play a role in the transport of organic anions including bile acids and bilirubin.
Super-classes obo:CHEBI_25367c

in vitro assayc # Classes

URI http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15958
Super-classes obo:OBI_0000070c
Sub-classes obo:TXPO_0000795c

Organic Cation Transporterc # Classes

URI http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21204
Super-classes obo:CHEBI_25367c

entityc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000001
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Sub-classes obo:BFO_0000003c
obo:BFO_0000002c
In domain of obo:TXPO_0001862op

continuantc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000002
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000001c
Sub-classes obo:BFO_0000031c
obo:BFO_0000020c
obo:BFO_0000004c
In domain of obo:RO_0000056op
In range of obo:RO_0000057op

occurrentc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000003
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000001c
Sub-classes obo:BFO_0000008c
obo:BFO_0000035c
obo:TXPO_0000270c
obo:BFO_0000015c
obo:BFO_0000011c
In domain of obo:RO_0000057op
obo:RO_0002012op
obo:BFO_0000066op
obo:RO_0002501op
In range of obo:RO_0002012op
obo:RO_0000056op
obo:RO_0002501op

independent continuantc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000004
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000002c
Sub-classes obo:BFO_0000040c
obo:BFO_0000141c
In range of obo:BFO_0000066op

spatial regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000006
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000141c
Sub-classes obo:BFO_0000009c
obo:BFO_0000018c
obo:BFO_0000028c
obo:BFO_0000026c

temporal regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000008
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000003c
Sub-classes obo:BFO_0000038c
obo:BFO_0000148c

two-dimensional spatial regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000009
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000006c

spatiotemporal regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000011
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000003c

processc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000015
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000003c
Sub-classes obo:TXPO_0000420c
obo:TXPO_0000271c
obo:BFO_0000144c
obo:TXPO_0000608c
obo:OBI_0000070c
In domain of obo:TXPO_0001873op
obo:RO_0002335op
obo:RO_0002336op
obo:TXPO_0000076op
obo:TXPO_0000069op
obo:RO_0002334op
obo:RO_0002211op
obo:TXPO_0000531op
In range of obo:TXPO_0000004op
obo:TXPO_0000076op
obo:RO_0002598op
obo:RO_0002335op
obo:RO_0002336op
obo:RO_0002334op
obo:TXPO_0000069op
obo:TXPO_0000774op
obo:RO_0002599op
obo:RO_0002211op

dispositionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000016
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000017c
Sub-classes obo:DOID_4c
obo:BFO_0000034c

realizable entityc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000017
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000020c
Sub-classes obo:BFO_0000023c
obo:BFO_0000016c

zero-dimensional spatial regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000018
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000006c

qualityc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000019
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000020c
Sub-classes obo:PATO_0000016c
obo:PATO_0000165c
obo:PATO_0002011c
obo:PATO_0000068c
obo:PATO_0000141c
obo:PATO_0000125c
obo:PATO_0001637c
obo:HP_0000118c
obo:PATO_0000146c
obo:PATO_0001884c
obo:PATO_0000169c
obo:PATO_0000117c
obo:PATO_0000069c
obo:BFO_0000145c
obo:PATO_0001035c
obo:PATO_0001024c
obo:PATO_0001906c
obo:PATO_0001842c
obo:PATO_0000060c
obo:PATO_0001025c
obo:PATO_0001464c
obo:PATO_0001159c
obo:TXPO_0000657c
obo:PATO_0001886c
obo:TXPO_0003753c
obo:PATO_0001230c
obo:PATO_0002353c
obo:PATO_0000039c
obo:PATO_0000070c
obo:PATO_0001309c
obo:PATO_0000048c
obo:PATO_0000014c
obo:PATO_0001236c
obo:PATO_0000970c
obo:PATO_0002070c
In range of obo:RO_0000086op

specifically dependent continuantc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000020
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000002c
Sub-classes obo:BFO_0000019c
obo:TXPO_0000300c
obo:BFO_0000017c
In range of obo:RO_0000053op

rolec # Classes

URI http://purl.obolibrary.org/obo/BFO_0000023
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000017c
Sub-classes obo:CHEBI_51086c
obo:TXPO_0001225c
obo:CHEBI_25944c
obo:TXPO_0003727c
obo:CHEBI_52210c
obo:CHEBI_52217c
obo:CHEBI_24432c
obo:TXPO_0002178c
obo:OBI_0000017c
In range of obo:RO_0000087op

fiat object partc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000024
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000040c
Sub-classes obo:UBERON_0001113c

one-dimensional spatial regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000026
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000006c

object aggregatec # Classes

URI http://purl.obolibrary.org/obo/BFO_0000027
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000040c
Sub-classes obo:TXPO_0002107c
obo:TXPO_0000065c
obo:TXPO_0000603c
obo:UBERON_0000463c

three-dimensional spatial regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000028
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000006c

sitec # Classes

URI http://purl.obolibrary.org/obo/BFO_0000029
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000141c

objectc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000030
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000040c
Sub-classes obo:CHEBI_24431c
obo:UBERON_0001062c
obo:GOCHE_50906c

generically dependent continuantc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000031
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000002c
Sub-classes obo:IAO_0000030c
obo:TXPO_0000275c

functionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000034
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000016c
In domain of obo:RO_0000079op
In range of obo:RO_0000085op

process boundaryc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000035
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000003c

one-dimensional temporal regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000038
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000008c

material entityc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000040
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000004c
Sub-classes obo:BFO_0000024c
obo:OBI_0100026c
obo:OGG_0000000002c
obo:BFO_0000030c
obo:BFO_0000027c
In domain of obo:TXPO_0003360op

continuant fiat boundaryc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000140
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000141c
Sub-classes obo:BFO_0000146c
obo:BFO_0000147c
obo:BFO_0000142c

immaterial entityc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000141
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000004c
Sub-classes obo:BFO_0000006c
obo:BFO_0000140c
obo:BFO_0000029c

one-dimensional continuant fiat boundaryc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000142
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000140c

process profilec # Classes

URI http://purl.obolibrary.org/obo/BFO_0000144
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000015c

relational qualityc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000145
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000019c

two-dimensional continuant fiat boundaryc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000146
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000140c

zero-dimensional continuant fiat boundaryc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000147
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000140c

zero-dimensional temporal regionc # Classes

URI http://purl.obolibrary.org/obo/BFO_0000148
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Super-classes obo:BFO_0000008c

voriconazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_10023
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50183c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL441C17c)

ciprofloxacinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_100241
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_50750c
obo:RO_0000087op some obo:CHEBI_59517c
obo:RO_0000087op some obo:CHEBI_53559c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL496C17c)
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_36047c
obo:RO_0000087op some obo:CHEBI_33281c
obo:RO_0000087op some obo:CHEBI_35441c

zafirlukastc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_10100
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_65023c
obo:RO_0000087op some obo:CHEBI_49159c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL526C17c)

zidovudinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_10110
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL563C17c)
obo:RO_0000087op some obo:CHEBI_36044c
obo:RO_0000087op some obo:CHEBI_53756c
obo:RO_0000087op some obo:CHEBI_35221c
Sub-classes obo:TXPO_0004387c

zileutonc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_10112
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_49159c
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_49167c
obo:RO_0000087op some obo:CHEBI_64964c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL602C17c)

diltiazemc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_101278
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_38215c
obo:RO_0000087op some obo:CHEBI_35620c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL637C17c)
obo:RO_0000087op some obo:CHEBI_35674c

erlotinibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_114785
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL672C17c)
obo:RO_0000087op some obo:CHEBI_37699c
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_74440c

nomifensinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_116225
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL699C17c)
obo:RO_0000087op some obo:CHEBI_51039c

efavirenzc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_119486
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL730C17c)
obo:RO_0000087op some obo:CHEBI_36044c
obo:RO_0000087op some obo:CHEBI_53756c

atomoxetinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_127342
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_35640c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL769C17c)
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35469c

lysophosphatidic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_132742
Super-classes obo:CHEBI_32957c
Restrictions obo:RO_0000087op some obo:TXPO_0003686c
obo:RO_0000087op some obo:TXPO_0002401c
Sub-classes obo:TXPO_0001857c

intermediate-density lipoproteinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_132933
Super-classes obo:CHEBI_6495c

farnesoid X receptor agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_132972
Super-classes obo:CHEBI_48705c

radiosensitizing agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_132992
Super-classes obo:CHEBI_23888c

fatty acid oxidation inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_133190
Super-classes obo:TXPO_0003648c
Restrictions obo:RO_0002599op some obo:GO_0019395c

NADc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_13389
Super-classes obo:CHEBI_36976c
Sub-classes obo:CHEBI_15846c
obo:CHEBI_16908c

mebanazinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_134728
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL860C17c)

isaxoninec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_134762
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL881C17c)

sulfacarbamidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_134891
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL902C17c)

tilbroquinolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_134965
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL923C17c)

milnacipranc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135005
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL944C17c)

nitrefazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135009
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL965C17c)

pirprofenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135028
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35475c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL993C17c)
Sub-classes obo:TXPO_0004364c

clomacranc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135273
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1014C17c)

zimeldinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135357
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1035C17c)

oxyphenisatinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135358
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1056C17c)

clometacinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135512
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1077C17c)

pipamazinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135641
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1098C17c)

alpidemc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135649
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35474c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1126C17c)
Sub-classes obo:TXPO_0004333c

tasosartanc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135666
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1147C17c)

niperotidinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135706
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1168C17c)

ebrotidinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135774
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1189C17c)

benziodaronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135814
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1210C17c)

alatrofloxacinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_135829
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1231C17c)

glycerophosphonocholinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_137209
Super-classes obo:CHEBI_37739c
Sub-classes obo:CHEBI_64482c

anxiogenicc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_137736
Super-classes obo:CHEBI_35471c

Hedgehog signaling pathway inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_140921
Super-classes obo:CHEBI_76932c

1,2-dichloropropanec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_142468
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0005060c

4-hydroxynonenalc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_142593
Super-classes obo:TXPO_0004328c
Sub-classes obo:TXPO_0005025c

tigecyclinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_149836
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_36047c

acetaldehydec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_15343
Super-classes obo:CHEBI_17478c
Sub-classes obo:TXPO_0003769c
obo:TXPO_0001634c

ATPc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_15422
Super-classes obo:CHEBI_36976c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

NAD(+)c # Classes

URI http://purl.obolibrary.org/obo/CHEBI_15846
Super-classes obo:CHEBI_13389c

polynucleotidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_15986
Super-classes obo:CHEBI_33694c
Sub-classes obo:CHEBI_33696c

GTPc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_15996
Super-classes obo:CHEBI_36976c

phosphatidylethanolaminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16038
Super-classes obo:CHEBI_36314c

cholesterolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16113
Super-classes obo:CHEBI_35341c

1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16152
Super-classes obo:CHEBI_37328c

ethanolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16236
Super-classes obo:CHEBI_30879c

phospholipidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16247
Super-classes obo:CHEBI_18059c
Sub-classes obo:CHEBI_37739c
obo:CHEBI_35786c

lithocholic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16325
Super-classes obo:TXPO_0000509c

adenosinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16335
Super-classes obo:CHEBI_33838c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

phosphatidic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16337
Super-classes obo:CHEBI_37739c

cholic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16359
Super-classes obo:TXPO_0000509c

sphingosinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16393
Super-classes obo:CHEBI_26739c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c

liposaccharidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16412
Description

Lipopolysaccharide (LPS) is a glycosylated lipid on the outer surface of Gram-negative bacteria acts as immunostimulants.
Super-classes obo:CHEBI_18059c
obo:CHEBI_18154c

17β-Estradiolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16469
Super-classes obo:CHEBI_23965c

NADPHc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16474
Super-classes obo:CHEBI_36976c

nitric oxidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16480
Super-classes obo:CHEBI_26519c

trichloroethylenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16602
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004675c

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16618
Super-classes obo:CHEBI_60169c

carbohydratec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16646
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_35381c
obo:CHEBI_18154c
obo:IMR_0001698c

albendazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16664
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1491C17c)
obo:RO_0000087op some obo:CHEBI_35443c
obo:RO_0000087op some obo:CHEBI_60832c
obo:RO_0000087op some obo:CHEBI_61951c

peptidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16670
Super-classes obo:CHEBI_23367c
Sub-classes obo:CHEBI_16856c
obo:TXPO_0000617c
obo:CHEBI_36080c

1-phosphatidyl-1D-myo-inositolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16749
Super-classes obo:CHEBI_28874c

guanosinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16750
Super-classes obo:CHEBI_33838c

chenodeoxycholic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16755
Description

InChIKey:RUDATBOHQWOJDD-BSWAIDMHSA-N
Super-classes obo:TXPO_0000509c
obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_75771c
obo:RO_0000087op some obo:CHEBI_77746c

AMPc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16761
Super-classes obo:CHEBI_36976c

L-gamma-glutamyl-L-cysteinylglycinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16856
Super-classes obo:CHEBI_16670c
Sub-classes obo:TXPO_0003164c

NADHc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16908
Super-classes obo:CHEBI_13389c

salicylic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16914
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35718c
Sub-classes obo:TXPO_0004352c

monoacylglycerol phosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16961
Super-classes obo:CHEBI_37739c
Sub-classes obo:CHEBI_32957c

bilirubinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16990
Super-classes obo:CHEBI_50860c

deoxyribonucleic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_16991
Super-classes obo:CHEBI_33696c
Sub-classes efo:EFO_0008480c

glucosec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17234
Super-classes obo:CHEBI_35381c

estronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17263
Super-classes obo:CHEBI_35341c
Sub-classes obo:TXPO_0002707c

myo-inositolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17268
Super-classes obo:CHEBI_24848c

testosteronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17347
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_75771c
obo:RO_0000087op some obo:CHEBI_77746c
obo:RO_0000087op some obo:CHEBI_50113c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1658C17c)
obo:RO_0000087op some obo:CHEBI_83056c

2-acetamidofluorenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17356
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004513c

CMPc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17361
Super-classes obo:TXPO_0002623c

aldehydec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17478
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_15343c
obo:TXPO_0004328c

phosphatidylglycerolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17517
Super-classes obo:CHEBI_24360c

gemcitabinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_175901
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_132992c
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35705c
obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_35703c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL1754C17c)
obo:RO_0000087op some obo:CHEBI_50266c
obo:RO_0000087op some obo:CHEBI_74213c
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_59517c
obo:RO_0000087op some obo:CHEBI_47868c
obo:RO_0000087op some obo:CHEBI_36044c

CTPc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17677
Super-classes obo:TXPO_0002623c

bis(2-ethylhexyl) phthalatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17747
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0005138c

ceramidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17761
Super-classes obo:CHEBI_26739c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c
Sub-classes obo:TXPO_0003543c
obo:TXPO_0003599c

gentamicinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17833
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0001425c
obo:TXPO_0000318c

triglyceridec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17855
Super-classes obo:CHEBI_50860c

Glutathione disulfidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17858
Super-classes obo:CHEBI_23367c

styrene oxidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17907
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004961c

N-hydroxy-2-acetamidofluorenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17931
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004705c

acyl-CoAc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_17984
Super-classes obo:CHEBI_72695c

lipidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18059
Description

Organic molecule that is insoluble in water but tends to dissolve in nonpolar organic solvent.
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_35741c
obo:CHEBI_26607c
obo:CHEBI_16412c
obo:TXPO_0000834c
obo:CHEBI_16247c
obo:CHEBI_24848c
obo:CHEBI_26739c
obo:CHEBI_35341c

polysaccharidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18154
Super-classes obo:CHEBI_33694c
obo:CHEBI_16646c
Sub-classes obo:IMR_0001789c
obo:CHEBI_16412c
obo:IMR_0001699c
obo:CHEBI_28087c

phosphoinositidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18179
Super-classes obo:CHEBI_28874c
Sub-classes obo:CHEBI_28765c

iron atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18248
Super-classes obo:CHEBI_33250c

phosphatidyl-L-serinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18303
Super-classes obo:CHEBI_35766c

1,4-dithiothreitolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18320
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_38161c
Sub-classes obo:TXPO_0001980c

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18348
Description

PI(4,5)P2 is cleaved by phospholipase C-beta or gamma to generate IP3 and diacylglycerol.
Super-classes obo:CHEBI_37328c

superoxidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_18421
Super-classes obo:TXPO_0000201c

ATP synthase inhibitor (mitochondrial respiratory-chain inhibitor)c # Classes

URI http://purl.obolibrary.org/obo/CHEBI_20854
Super-classes obo:CHEBI_25355c

aflatoxinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22271
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_2504c
obo:CHEBI_30725c

alkali metal atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22314
Super-classes obo:CHEBI_33521c
Sub-classes obo:CHEBI_26216c
obo:CHEBI_26708c

alkylating agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22333
Super-classes obo:TXPO_0001316c
obo:CHEBI_25435c

anionc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22563
Super-classes obo:CHEBI_24870c

antioxidantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22586
Super-classes obo:CHEBI_51086c
Sub-classes obo:CHEBI_48578c

antiviral agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22587
Super-classes obo:CHEBI_33281c
Sub-classes obo:CHEBI_59897c
obo:CHEBI_64946c
obo:CHEBI_36044c

barbituratesc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22693
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_8069c

basec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22695
Super-classes obo:CHEBI_51086c
Sub-classes obo:CHEBI_59740c

calcium atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_22984
Super-classes obo:CHEBI_33250c

EC 4.2.1.1 (carbonic anhydrase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23018
Super-classes obo:CHEBI_76907c

chemosterilantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23092
Super-classes obo:CHEBI_25944c
Sub-classes obo:CHEBI_67105c

coenzymec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23354
Super-classes obo:CHEBI_23357c

cofactorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23357
Super-classes obo:TXPO_0003732c
Sub-classes obo:CHEBI_23354c

molecular entityc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23367
Super-classes obo:CHEBI_24431c
Sub-classes obo:CHEBI_16670c
obo:CHEBI_36357c
obo:CHEBI_26519c
obo:CHEBI_24870c
obo:CHEBI_24636c
obo:CHEBI_17858c
obo:CHEBI_24195c
obo:CHEBI_25806c
obo:CHEBI_25367c

4-(phenylazo)anilinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_233869
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004892c

acarbosec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_2376
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2048C17c)
obo:RO_0000087op some obo:CHEBI_67239c
obo:RO_0000087op some obo:CHEBI_35526c
obo:RO_0000087op some obo:CHEBI_50627c

drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23888
Super-classes obo:CHEBI_52217c
obo:CHEBI_52210c
Sub-classes obo:CHEBI_55324c
obo:CHEBI_35610c
obo:CHEBI_35554c
obo:CHEBI_50857c
obo:CHEBI_65023c
obo:CHEBI_51061c
obo:CHEBI_50739c
obo:CHEBI_132992c
obo:CHEBI_48422c
obo:CHEBI_35846c
obo:CHEBI_66956c
obo:CHEBI_50646c
obo:CHEBI_48407c
obo:CHEBI_50177c
obo:CHEBI_50248c
obo:CHEBI_35470c
obo:CHEBI_90710c
obo:CHEBI_35498c
obo:CHEBI_47868c
obo:CHEBI_48676c
obo:CHEBI_35472c
obo:CHEBI_88188c
obo:CHEBI_35480c
obo:CHEBI_50267c
obo:CHEBI_35942c
obo:CHEBI_50266c
obo:CHEBI_49201c
obo:CHEBI_35441c
obo:CHEBI_50846c
obo:CHEBI_52726c
obo:CHEBI_49167c
obo:CHEBI_35842c
obo:CHEBI_50689c
obo:CHEBI_50926c
obo:CHEBI_35679c
obo:CHEBI_35497c
obo:CHEBI_35526c
obo:CHEBI_51372c
obo:CHEBI_35493c
obo:CHEBI_50751c

icosanoidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23899
Super-classes obo:CHEBI_61697c
Sub-classes obo:CHEBI_73693c
obo:CHEBI_26347c
obo:IMR_0100021c

enzyme inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23924
Super-classes obo:TXPO_0003711c
obo:CHEBI_52206c
obo:CHEBI_35222c
Sub-classes obo:CHEBI_71300c
obo:CHEBI_76932c
obo:CHEBI_76710c
obo:TXPO_0002399c
obo:CHEBI_76725c
obo:CHEBI_77113c
obo:CHEBI_75596c
obo:CHEBI_50925c
obo:CHEBI_76759c

estradiolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23965
Description

InChIKey=VOXZDWNPVJITMN-WKUFJEKOSA-N
Super-classes obo:CHEBI_35341c
Sub-classes obo:CHEBI_16469c

N-ethyl-N-nitrosoureac # Classes

URI http://purl.obolibrary.org/obo/CHEBI_23995
Super-classes obo:CHEBI_50860c

bromfenacc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_240107
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35475c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2122C17c)
obo:RO_0000087op some obo:CHEBI_35481c

fungicidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24127
Super-classes obo:CHEBI_25944c
obo:CHEBI_35718c

gamma-glutamylcysteinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24195
Super-classes obo:CHEBI_23367c

glycerophosphoglycerolsc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24360
Super-classes obo:CHEBI_37739c
Sub-classes obo:CHEBI_90454c
obo:CHEBI_17517c

chemical entityc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24431
Super-classes obo:BFO_0000030c
Sub-classes obo:CHEBI_50860c
obo:CHEBI_23367c
obo:TXPO_0001820c
obo:TXPO_0003575c
obo:TXPO_0001731c
obo:CHEBI_33250c

biological rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24432
Super-classes obo:BFO_0000023c
Sub-classes obo:CHEBI_52206c
obo:CHEBI_35703c
obo:CHEBI_52290c
obo:CHEBI_33290c
obo:CHEBI_35222c
obo:CHEBI_33280c
obo:CHEBI_52209c
obo:CHEBI_52208c
obo:CHEBI_52210c
obo:CHEBI_50846c
obo:CHEBI_64909c
obo:CHEBI_33281c

hormonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24621
Description

substance with hormone role: http://purl.bioontology.org/ontology/STY/T125
Super-classes obo:CHEBI_48705c
obo:CHEBI_33280c
Sub-classes obo:CHEBI_37845c
obo:CHEBI_36413c
obo:CHEBI_50112c

protonc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24636
Super-classes obo:CHEBI_23367c

iminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24783
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_29132c

inositolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24848
Super-classes obo:CHEBI_18059c
Sub-classes obo:CHEBI_17268c

insecticidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24852
Super-classes obo:CHEBI_25944c
Sub-classes obo:CHEBI_67105c

ionc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_24870
Super-classes obo:CHEBI_23367c
Sub-classes obo:TXPO_0000052c
obo:CHEBI_22563c

aflatoxin B1c # Classes

URI http://purl.obolibrary.org/obo/CHEBI_2504
Super-classes obo:CHEBI_22271c
Sub-classes obo:TXPO_0004907c

metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25212
Super-classes obo:CHEBI_52206c
Sub-classes obo:CHEBI_76206c
obo:CHEBI_48887c
obo:CHEBI_75787c
obo:TXPO_0003600c
obo:CHEBI_75763c

mitochondrial respiratory-chain inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25355
Super-classes obo:CHEBI_38497c
Sub-classes obo:CHEBI_20854c

moleculec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25367
Super-classes obo:CHEBI_23367c
Sub-classes obo:TXPO_0000666c
obo:TXPO_1000204c
obo:IMR_0000541c
obo:IMR_0000409c
obo:IMR_0000397c
obo:IMR_0000305c
obo:TXPO_1000418c
obo:TXPO_1000032c
obo:IMR_0000605c
obo:TXPO_0003119c
obo:TXPO_0005098c
obo:TXPO_0001312c
obo:TXPO_0001558c
obo:TXPO_0004730c
obo:TXPO_0000740c
obo:TXPO_0001020c
obo:TXPO_1000170c
obo:IMR_0000249c
obo:TXPO_0003840c
obo:TXPO_1000271c
obo:TXPO_0005069c
obo:IMR_0000370c
obo:TXPO_1000385c
obo:TXPO_1000165c
obo:TXPO_1000205c
obo:IMR_0100712c
obo:TXPO_1000507c
obo:TXPO_1000194c
obo:TXPO_0005087c
obo:TXPO_0000665c
obo:IMR_0000383c
obo:TXPO_1000399c
obo:TXPO_1000529c
obo:OGG_3000008431c
obo:IMR_0000015c
obo:IMR_0000257c
obo:TXPO_1000340c
obo:TXPO_0004645c
obo:TXPO_0003823c
obo:TXPO_1000361c
obo:IMR_0100464c
obo:TXPO_0005094c
obo:IMR_0000442c
obo:TXPO_1000260c
obo:TXPO_1000063c
obo:TXPO_1000152c
obo:TXPO_1000045c
obo:TXPO_1000116c
obo:IMR_0000552c
obo:TXPO_1000308c
obo:IMR_0100153c
obo:IMR_0010020c
obo:TXPO_0003843c
obo:TXPO_1000376c
obo:IMR_0010016c
obo:TXPO_1000522c
obo:TXPO_1000302c
obo:TXPO_1000313c
obo:TXPO_1000250c
obo:IMR_0010278c
obo:TXPO_0001111c
obo:TXPO_1000383c
obo:TXPO_1000004c
obo:TXPO_0004799c
obo:TXPO_1000322c
obo:IMR_0001711c
obo:TXPO_1000401c
obo:TXPO_0000372c
obo:TXPO_1000300c
obo:TXPO_1000127c
obo:IMR_0000402c
obo:TXPO_1000267c
obo:TXPO_1000407c
obo:IMR_0000432c
obo:TXPO_1000126c
obo:TXPO_1000089c
obo:TXPO_1000123c
obo:IMR_0000068c
obo:IMR_0100659c
obo:TXPO_1000193c
obo:TXPO_1000240c
obo:TXPO_0001517c
obo:IMR_0000774c
obo:TXPO_1000535c
obo:TXPO_1000379c
obo:TXPO_0002089c
obo:TXPO_0002802c
obo:IMR_0001865c
obo:IMR_0000316c
obo:TXPO_1000408c
obo:TXPO_0001424c
obo:TXPO_1000125c
obo:IMR_0000558c
obo:IMR_0000187c
obo:TXPO_1000003c
obo:IMR_0100636c
obo:TXPO_0004772c
obo:TXPO_0003835c
obo:TXPO_0004467c
obo:TXPO_1000241c
obo:TXPO_1000391c
obo:TXPO_1000174c
obo:TXPO_1000279c
obo:IMR_0000224c
obo:TXPO_1000286c
obo:TXPO_1000016c
obo:TXPO_1000519c
obo:TXPO_1000527c
obo:IMR_0000016c
obo:IMR_0000745c
obo:IMR_0100465c
obo:TXPO_1000335c
obo:TXPO_0003974c
obo:IMR_0000342c
obo:TXPO_1000249c
obo:TXPO_1000523c
obo:TXPO_0001528c
obo:TXPO_1000131c
obo:TXPO_1000129c
obo:IMR_0000526c
obo:TXPO_1000264c
obo:TXPO_1000002c
obo:IMR_0000356c
obo:TXPO_1000320c
obo:TXPO_1000331c
obo:TXPO_1000220c
obo:TXPO_1000054c
obo:TXPO_1000344c
obo:TXPO_1000039c
obo:TXPO_1000533c
obo:TXPO_0004748c
obo:IMR_0000192c
obo:IMR_0000650c
obo:TXPO_1000268c
obo:TXPO_1000072c
obo:IMR_0000092c
obo:TXPO_1000394c
obo:TXPO_1000419c
obo:TXPO_1000528c
obo:IMR_0000027c
obo:TXPO_1000068c
obo:TXPO_1000374c
obo:TXPO_1000114c
obo:IMR_0000966c
obo:TXPO_1000299c
obo:IMR_0000167c
obo:TXPO_1000520c
obo:TXPO_1000066c
obo:TXPO_0005088c
obo:TXPO_1000540c
obo:TXPO_1000296c
obo:TXPO_1000202c
obo:TXPO_1000055c
obo:TXPO_1000386c
obo:IMR_0000018c
obo:TXPO_0003817c
obo:IMR_0000229c
obo:TXPO_1000140c
obo:TXPO_1000261c
obo:TXPO_1000197c
obo:TXPO_1000195c
obo:TXPO_1000148c
obo:IMR_0100704c
obo:TXPO_1000546c
obo:TXPO_1000532c
obo:TXPO_1000348c
obo:TXPO_1000515c
obo:IMR_0003045c
obo:TXPO_1000422c
obo:IMR_0001923c
obo:TXPO_1000403c
obo:TXPO_1000198c
obo:TXPO_1000315c
obo:TXPO_1000303c
obo:TXPO_0005092c
obo:TXPO_1000294c
obo:TXPO_1000169c
obo:IMR_0000546c
obo:TXPO_1000372c
obo:IMR_0000825c
obo:IMR_0000202c
obo:TXPO_1000185c
obo:TXPO_1000387c
obo:TXPO_1000288c
obo:IMR_0000217c
obo:TXPO_1000353c
obo:IMR_0001372c
obo:TXPO_1000358c
obo:TXPO_1000534c
obo:IMR_0100648c
obo:TXPO_1000330c
obo:IMR_0100258c
obo:TXPO_0003833c
obo:IMR_0000417c
obo:TXPO_1000405c
obo:TXPO_1000334c
obo:TXPO_1000269c
obo:IMR_0000084c
obo:TXPO_1000501c
obo:TXPO_0002527c
obo:IMR_0000255c
obo:TXPO_1000278c
obo:TXPO_0001417c
obo:IMR_0000421c
obo:IMR_0000007c
obo:IMR_0000178c
obo:TXPO_1000181c
obo:TXPO_1000397c
obo:TXPO_1000119c
obo:TXPO_1000336c
obo:TXPO_1000510c
obo:TXPO_1000010c
obo:TXPO_1000295c
obo:TXPO_0005100c
obo:TXPO_1000384c
obo:TXPO_1000203c
obo:TXPO_1000504c
obo:TXPO_0000014c
obo:TXPO_1000324c
obo:IMR_0000463c
obo:TXPO_0005102c
obo:TXPO_0004406c
obo:TXPO_1000274c
obo:TXPO_1000053c
obo:TXPO_1000272c
obo:IMR_0001206c
obo:IMR_0000426c
obo:TXPO_0004782c
obo:TXPO_0003120c
obo:IMR_0000422c
obo:TXPO_1000542c
obo:TXPO_1000154c
obo:IMR_0000454c
obo:TXPO_1000052c
obo:TXPO_1000218c
obo:TXPO_1000138c
obo:TXPO_1000162c
obo:TXPO_0000120c
obo:TXPO_0001094c
obo:TXPO_1000178c
obo:IMR_0000460c
obo:TXPO_0004744c
obo:TXPO_1000173c
obo:TXPO_1000263c
obo:IMR_0010012c
obo:TXPO_1000350c
obo:TXPO_1000098c
obo:TXPO_0001007c
obo:TXPO_0004581c
obo:TXPO_1000186c
obo:IMR_0000374c
obo:TXPO_1000525c
obo:TXPO_0004613c
obo:IMR_0000444c
obo:TXPO_0005096c
obo:IMR_0002804c
obo:IMR_0000522c
obo:TXPO_1000255c
obo:TXPO_0004685c
obo:IMR_0000897c
obo:IMR_0000310c
obo:TXPO_1000070c
obo:TXPO_1000351c
obo:IMR_0001423c
obo:IMR_0100271c
obo:TXPO_1000355c
obo:TXPO_1000134c
obo:TXPO_1000050c
obo:TXPO_1000366c
obo:TXPO_1000153c
obo:TXPO_1000223c
obo:TXPO_1000275c
obo:TXPO_1000276c
obo:TXPO_1000253c
obo:IMR_0100702c
obo:TXPO_1000146c
obo:TXPO_1000188c
obo:TXPO_0001148c
obo:TXPO_0005136c
obo:TXPO_1000378c
obo:IMR_0000153c
obo:TXPO_1000056c
obo:TXPO_0000282c
obo:TXPO_1000075c
obo:IMR_0002090c
obo:TXPO_0005137c
obo:TXPO_1000258c
obo:IMR_0000559c
obo:TXPO_1000190c
obo:TXPO_1000209c
obo:TXPO_1000337c
obo:IMR_0010013c
obo:TXPO_1000229c
obo:TXPO_0003221c
obo:TXPO_1000317c
obo:TXPO_1000065c
obo:IMR_0010387c
obo:IMR_0000211c
obo:TXPO_0003158c
obo:IMR_0000180c
obo:TXPO_1000287c
obo:IMR_0000204c
obo:TXPO_1000356c
obo:TXPO_1000150c
obo:IMR_0002688c
obo:TXPO_1000215c
obo:TXPO_1000252c
obo:IMR_0002576c
obo:TXPO_1000051c
obo:TXPO_0005093c
obo:TXPO_0000033c
obo:IMR_0000339c
obo:TXPO_1000043c
obo:IMR_0000547c
obo:TXPO_1000365c
obo:TXPO_1000213c
obo:TXPO_1000347c
obo:TXPO_0000321c
obo:IMR_0001422c
obo:TXPO_1000037c
obo:TXPO_1000244c
obo:TXPO_0004715c
obo:TXPO_0004709c
obo:TXPO_0000737c
obo:TXPO_1000500c
obo:TXPO_1000343c
obo:TXPO_0000635c
obo:IMR_0002950c
obo:TXPO_1000362c
obo:IMR_0000888c
obo:TXPO_0005132c
obo:IMR_0000212c
obo:IMR_0100660c
obo:TXPO_1000293c
obo:TXPO_1000230c
obo:IMR_0000213c
obo:IMR_0000433c
obo:TXPO_0001931c
obo:TXPO_1000309c
obo:TXPO_0001792c
obo:IMR_0010628c
obo:TXPO_1000381c
obo:TXPO_1000521c
obo:TXPO_1000136c
obo:IMR_0000021c
obo:TXPO_1000097c
obo:TXPO_1000359c
obo:TXPO_1000207c
obo:IMR_0000416c
obo:TXPO_0003839c
obo:TXPO_1000329c
obo:TXPO_0003832c
obo:IMR_0000004c
obo:IMR_0001844c
obo:IMR_0000896c
obo:TXPO_1000036c
obo:IMR_0000075c
obo:IMR_0002835c
obo:IMR_0000266c
obo:TXPO_1000044c
obo:IMR_0000245c
obo:TXPO_1000318c
obo:TXPO_1000319c
obo:IMR_0010283c
ncicp:C21204c
obo:TXPO_1000235c
obo:TXPO_0001002c
obo:IMR_0000189c
obo:TXPO_1000304c
obo:TXPO_1000060c
obo:TXPO_1000009c
obo:IMR_0000017c
obo:TXPO_1000216c
obo:TXPO_1000245c
obo:TXPO_1000398c
obo:TXPO_1000352c
obo:TXPO_1000124c
obo:TXPO_1000085c
obo:TXPO_1000314c
obo:TXPO_1000321c
obo:TXPO_1000339c
obo:IMR_0000411c
obo:IMR_0000191c
obo:TXPO_1000325c
obo:TXPO_1000145c
obo:TXPO_1000149c
obo:TXPO_1000547c
obo:TXPO_1000393c
obo:TXPO_1000266c
obo:TXPO_0005127c
obo:IMR_0000701c
obo:TXPO_1000221c
obo:TXPO_1000242c
obo:TXPO_0000587c
obo:IMR_0000142c
obo:TXPO_1000006c
obo:TXPO_0004399c
obo:TXPO_1000156c
obo:IMR_0000418c
obo:TXPO_1000001c
obo:TXPO_1000160c
obo:TXPO_0003241c
obo:TXPO_0001022c
obo:TXPO_1000539c
obo:IMR_0000351c
obo:TXPO_1000514c
obo:TXPO_1000310c
obo:TXPO_1000524c
obo:TXPO_0004563c
obo:TXPO_1000371c
obo:IMR_0000868c
obo:TXPO_1000222c
obo:TXPO_1000536c
obo:TXPO_0003284c
obo:TXPO_1000071c
obo:TXPO_1000161c
obo:TXPO_1000341c
obo:TXPO_0005128c
obo:TXPO_0004228c
obo:TXPO_1000516c
obo:TXPO_1000166c
obo:TXPO_1000206c
obo:IMR_0000206c
obo:TXPO_1000163c
obo:IMR_0100540c
obo:IMR_0000269c
obo:TXPO_1000228c
obo:IMR_0000056c
obo:TXPO_1000289c
obo:TXPO_1000543c
obo:TXPO_1000298c
obo:IMR_0000456c
obo:TXPO_1000530c
obo:IMR_0100463c
obo:TXPO_0003254c
obo:IMR_0000254c
obo:TXPO_0004521c
obo:TXPO_1000390c
obo:IMR_0000974c
obo:TXPO_1000360c
obo:TXPO_1000159c
obo:TXPO_1000357c
obo:TXPO_1000047c
obo:TXPO_1000192c
obo:TXPO_1000189c
obo:TXPO_0001106c
obo:IMR_0000190c
obo:TXPO_1000369c
obo:IMR_0000256c
obo:TXPO_1000368c
obo:IMR_0000020c
obo:TXPO_1000262c
obo:TXPO_1000311c
obo:TXPO_1000008c
obo:TXPO_0004565c
obo:TXPO_0005119c
obo:TXPO_1000435c
obo:IMR_0100488c
obo:TXPO_0000856c
obo:TXPO_0001124c
obo:TXPO_0001014c
obo:TXPO_1000120c
obo:TXPO_1000091c
obo:TXPO_1000121c
obo:TXPO_1000227c
obo:TXPO_1000211c
obo:TXPO_1000115c
obo:TXPO_1000345c
obo:IMR_0000301c
obo:TXPO_1000306c
obo:TXPO_0003841c
obo:TXPO_1000143c
obo:TXPO_1000224c
obo:IMR_0000089c
obo:TXPO_1000316c
obo:IMR_0000445c
obo:IMR_0000172c
obo:TXPO_1000389c
obo:IMR_0000295c
obo:IMR_0100512c
obo:TXPO_1000531c
obo:IMR_0100701c
obo:TXPO_0001443c
obo:TXPO_1000406c
obo:TXPO_1000058c
obo:IMR_0100809c
obo:TXPO_1000375c
obo:TXPO_1000232c
obo:TXPO_1000503c
obo:IMR_0000347c
obo:TXPO_1000254c
obo:CHEBI_72695c
obo:TXPO_1000307c
obo:TXPO_0001509c
obo:TXPO_1000158c
obo:TXPO_1000290c
obo:TXPO_0000877c
obo:TXPO_1000544c
obo:TXPO_0003970c
obo:IMR_0000560c
obo:TXPO_1000182c
obo:IMR_0001204c
obo:TXPO_0000849c
obo:IMR_0000535c
obo:TXPO_1000333c
obo:IMR_0000193c
obo:IMR_0000250c
obo:IMR_0001692c
obo:TXPO_1000029c
obo:TXPO_1000191c
obo:TXPO_1000062c
obo:TXPO_1000141c
obo:IMR_0100207c
obo:IMR_0000554c
obo:TXPO_1000248c
obo:TXPO_1000076c
obo:IMR_0000300c
obo:TXPO_1000246c
obo:IMR_0100543c
obo:TXPO_1000094c
obo:TXPO_1000285c
obo:TXPO_1000431c
obo:TXPO_1000273c
obo:IMR_0100149c
obo:TXPO_1000038c
obo:TXPO_1000367c
obo:TXPO_0003834c
obo:IMR_0000156c
obo:TXPO_1000380c
obo:TXPO_0001382c
obo:TXPO_1000077c
obo:TXPO_1000231c
obo:TXPO_1000177c
obo:IMR_0000151c
obo:TXPO_1000112c
obo:TXPO_0001877c
obo:TXPO_1000074c
obo:TXPO_0000785c
obo:TXPO_1000031c
obo:TXPO_1000111c
obo:TXPO_1000332c
obo:TXPO_1000095c
obo:IMR_0000462c
obo:IMR_0100466c
obo:IMR_0100755c
ncicp:C107150c
obo:TXPO_1000297c
obo:IMR_0001091c
obo:IMR_0000515c
obo:IMR_0000299c
obo:TXPO_1000239c
obo:IMR_0000520c
obo:TXPO_0004707c
obo:TXPO_0004290c
obo:TXPO_0002694c
obo:TXPO_1000512c
obo:IMR_0000451c
obo:TXPO_1000183c
obo:TXPO_1000354c
obo:IMR_0000271c
obo:TXPO_1000135c
obo:TXPO_1000541c
obo:TXPO_0003966c
obo:TXPO_1000377c
obo:TXPO_1000018c
obo:TXPO_0000613c
obo:TXPO_1000030c
obo:TXPO_0005134c
obo:IMR_0000415c
obo:IMR_0000220c
obo:TXPO_0000150c
obo:TXPO_0003287c
obo:TXPO_1000277c
obo:TXPO_0001146c
obo:TXPO_1000301c
obo:TXPO_1000212c
obo:TXPO_1000064c
obo:IMR_0000331c
obo:TXPO_1000210c
obo:TXPO_1000349c
obo:TXPO_1000118c
obo:TXPO_0005068c
obo:TXPO_1000508c
obo:IMR_0100718c
obo:IMR_0000125c
obo:TXPO_0003836c
obo:TXPO_0004815c
obo:IMR_0000386c
obo:TXPO_1000017c
obo:IMR_0000134c
obo:TXPO_1000233c
obo:TXPO_1000328c
obo:TXPO_1000545c
obo:TXPO_1000395c
obo:TXPO_1000280c
obo:TXPO_1000370c
obo:TXPO_0004778c
obo:TXPO_0001098c
obo:IMR_0000289c
obo:IMR_0002411c
obo:TXPO_1000187c
obo:TXPO_0003842c
obo:IMR_0001409c
obo:TXPO_1000234c
obo:IMR_0000431c
obo:TXPO_1000502c
obo:TXPO_1000415c
obo:TXPO_1000144c
obo:TXPO_1000168c
obo:TXPO_1000061c
obo:TXPO_1000259c
obo:TXPO_0004711c
obo:TXPO_1000243c
obo:IMR_0000200c
obo:TXPO_0004486c
obo:IMR_0100165c
obo:TXPO_1000265c
obo:TXPO_1000338c
obo:TXPO_0003837c
obo:IMR_0000003c
obo:TXPO_1000517c
obo:TXPO_1000256c
obo:IMR_0000259c
obo:IMR_0010280c
obo:IMR_0100166c
obo:TXPO_0005133c
obo:IMR_0000081c
obo:TXPO_1000196c
obo:IMR_0010281c
obo:TXPO_1000128c
obo:TXPO_1000400c
obo:TXPO_0004231c
obo:IMR_0100002c
obo:TXPO_0005130c
obo:TXPO_1000014c
obo:TXPO_0004713c
obo:TXPO_1000007c
obo:IMR_0000096c
obo:TXPO_1000270c
obo:TXPO_1000392c
obo:TXPO_1000537c
obo:TXPO_0001883c
obo:IMR_0000251c
obo:TXPO_0005079c
obo:TXPO_0000298c
obo:TXPO_1000346c
obo:TXPO_1000090c
obo:TXPO_1000305c
obo:IMR_0100700c
obo:TXPO_1000388c
obo:TXPO_0005135c
obo:TXPO_0004608c
obo:IMR_0000894c
obo:TXPO_1000219c
obo:TXPO_1000157c
obo:TXPO_1000509c
obo:TXPO_1000292c
obo:TXPO_0003223c
obo:TXPO_1000236c
obo:TXPO_1000414c
obo:TXPO_1000184c
obo:TXPO_0004604c
obo:TXPO_1000409c
obo:TXPO_1000251c
obo:IMR_0100703c
obo:TXPO_1000199c
obo:TXPO_1000096c
obo:TXPO_1000086c
obo:TXPO_1000005c
obo:TXPO_1000342c
obo:TXPO_1000225c
obo:IMR_0002721c
obo:TXPO_0003981c
obo:TXPO_1000139c
obo:IMR_0000205c
obo:TXPO_1000033c
obo:TXPO_1000034c
obo:TXPO_1000110c
obo:IMR_0000382c
obo:TXPO_0005103c
obo:IMR_0000124c
obo:TXPO_0004020c
obo:TXPO_1000067c
obo:TXPO_0003121c
obo:TXPO_1000238c
obo:TXPO_1000217c
obo:IMR_0000080c
obo:TXPO_1000511c
obo:IMR_0100192c
obo:TXPO_0002365c
obo:TXPO_1000073c
obo:TXPO_1000513c
obo:TXPO_1000035c
obo:TXPO_1000137c
obo:TXPO_0002331c
obo:IMR_0100382c
obo:TXPO_1000147c
obo:TXPO_0000563c
obo:TXPO_1000323c
obo:TXPO_1000093c
obo:TXPO_1000167c
obo:TXPO_1000171c
obo:TXPO_1000518c
obo:IMR_0100606c
obo:TXPO_1000164c
obo:IMR_0010024c
obo:TXPO_0000780c
obo:TXPO_1000364c
obo:IMR_0000203c
obo:TXPO_1000506c
obo:IMR_0002658c
obo:TXPO_1000059c
obo:TXPO_1000214c
obo:TXPO_1000046c
obo:IMR_0000274c
obo:TXPO_1000048c
obo:TXPO_1000538c
obo:TXPO_1000142c
obo:IMR_0002410c
obo:TXPO_0004621c
obo:TXPO_1000015c
obo:TXPO_1000092c
obo:TXPO_1000526c
obo:TXPO_0003838c
obo:TXPO_1000057c

mutagenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25435
Super-classes obo:CHEBI_50902c
Sub-classes obo:CHEBI_22333c

mycotoxinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25442
Super-classes obo:CHEBI_27026c

7,12-dimethyltetraphenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_254496
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004891c

nematicidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25491
Super-classes obo:CHEBI_25944c
Sub-classes obo:CHEBI_35444c

neurotransmitterc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25512
Super-classes obo:CHEBI_33280c

nitrogen atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25555
Super-classes obo:CHEBI_33250c

organophosphorus compoundc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25710
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_36711c

oxygen atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25805
Super-classes obo:CHEBI_33250c

oxygen molecular entityc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25806
Super-classes obo:CHEBI_23367c
Sub-classes obo:CHEBI_26523c

hydroperoxylc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25935
Super-classes obo:TXPO_0000201c

pesticidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_25944
Super-classes obo:BFO_0000023c
Sub-classes obo:CHEBI_25491c
obo:CHEBI_24852c
obo:CHEBI_86328c
obo:CHEBI_24127c
obo:CHEBI_23092c

potassium atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26216
Super-classes obo:CHEBI_22314c

prostanoidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26347
Super-classes obo:CHEBI_23899c
Sub-classes obo:CHEBI_26995c
obo:IMR_0100019c

radicalc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26519
Super-classes obo:CHEBI_23367c
Sub-classes obo:CHEBI_30737c
obo:TXPO_0000201c
obo:CHEBI_16480c
obo:TXPO_0004317c

reactive oxygen speciesc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26523
Super-classes obo:CHEBI_25806c

saturated fatty acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26607
Super-classes obo:CHEBI_18059c
Sub-classes obo:TXPO_0005058c

amiodaronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_2663
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2384C17c)
obo:RO_0000086op some obo:PATO_0001886c
obo:RO_0000086op some obo:PATO_0001884c
obo:RO_0000087op some obo:CHEBI_35554c
Sub-classes obo:TXPO_0004332c
obo:TXPO_0000317c
obo:TXPO_0003227c
obo:TXPO_0000880c
obo:TXPO_0003226c

amitriptylinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_2666
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0001566c

sodium atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26708
Super-classes obo:CHEBI_22314c

sphingolipidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26739
Super-classes obo:CHEBI_18059c
Sub-classes obo:CHEBI_17761c
obo:CHEBI_16393c
obo:CHEBI_35786c

sulfur atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26833
Super-classes obo:CHEBI_33250c

thromboxanec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_26995
Super-classes obo:CHEBI_26347c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c
obo:RO_0000087op some obo:TXPO_0003686c

toxinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27026
Super-classes obo:CHEBI_64909c
Sub-classes obo:CHEBI_25442c

triolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27136
Super-classes obo:CHEBI_50860c

uric acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27226
Super-classes obo:CHEBI_50860c

tetrachloromethanec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27385
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003772c
obo:TXPO_0004316c
obo:TXPO_0004454c
obo:TXPO_0001981c
obo:TXPO_0003509c

carbon atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27594
Super-classes obo:CHEBI_33250c

acetazolamidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27690
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2498C17c)
obo:RO_0000087op some obo:CHEBI_35623c
obo:RO_0000087op some obo:CHEBI_35498c
obo:RO_0000087op some obo:CHEBI_23018c

griseofulvinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27779
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_76964c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2529C17c)
obo:RO_0000087op some obo:CHEBI_33282c

resveratrolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27881
Super-classes obo:TXPO_0000591c
Restrictions obo:RO_0000087op some obo:CHEBI_22586c
Sub-classes obo:TXPO_0003027c

tetracyclinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_27902
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_33281c
Sub-classes obo:TXPO_0004336c

rifampicinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28077
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0001885c

glycogenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28087
Super-classes obo:CHEBI_18154c

papaverinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28241
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2602C17c)
obo:RO_0000087op some obo:CHEBI_35620c
obo:RO_0000087op some obo:CHEBI_53784c

aristolochic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_2825
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004922c

cardiolipinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28494
Super-classes obo:CHEBI_37739c

chloroethenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28509
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004498c

cytarabinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28680
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2668C17c)
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_22587c
obo:RO_0000087op some obo:CHEBI_35705c

fructosec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28757
Super-classes obo:CHEBI_35381c

phosphatidylinositol phosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28765
Super-classes obo:CHEBI_18179c
Sub-classes obo:CHEBI_60169c
obo:CHEBI_37328c

coumarinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28794
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0002065c

deoxycholic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28834
Super-classes obo:TXPO_0000509c

phosphatidylinositolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28874
Super-classes obo:CHEBI_36315c
Sub-classes obo:CHEBI_18179c
obo:CHEBI_16749c

1-hydroxyanthraquinonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28877
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0005062c

busulfanc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_28901
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50905c
obo:RO_0000087op some obo:CHEBI_50903c
obo:RO_0000087op some obo:CHEBI_22333c
obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2755C17c)
obo:RO_0000087op some obo:CHEBI_67105c

N-acetyl-1,4-benzoquinone iminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_29132
Super-classes obo:CHEBI_24783c
Sub-classes obo:TXPO_0000974c

hydroxylc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_29191
Super-classes obo:TXPO_0000201c

azathioprinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_2948
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50266c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2822C17c)
obo:RO_0000087op some obo:CHEBI_59517c
obo:RO_0000087op some obo:CHEBI_35705c
obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_50908c
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_50903c

telithromycinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_29688
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2844C17c)

tunicamycinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_29699
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003818c
obo:TXPO_0003819c
obo:TXPO_0001962c

benzbromaronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3023
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35841c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2878C17c)

aflatoxin B1 exo-8,9-epoxidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_30725
Super-classes obo:CHEBI_22271c
Sub-classes obo:TXPO_0004909c

trichloromethyl(.)c # Classes

URI http://purl.obolibrary.org/obo/CHEBI_30737
Super-classes obo:CHEBI_26519c
Sub-classes obo:TXPO_0003630c

alcoholc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_30879
Super-classes obo:CHEBI_72695c
Sub-classes obo:TXPO_0004384c
obo:CHEBI_16236c
obo:TXPO_0004924c

bicalutamidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3090
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2941C17c)
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35497c

trichloroacetic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_30956
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004676c

alclofenacc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_31183
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_88188c
obo:RO_0000087op some obo:CHEBI_35475c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL2985C17c)
obo:RO_0000087op some obo:CHEBI_35481c

bendazacc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_31257
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_48578c
obo:RO_0000087op some obo:CHEBI_35475c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3016C17c)

Cyclofenilc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_31446
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3038C17c)

febuxostatc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_31596
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35634c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3065C17c)

glafeninec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_31653
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35222c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3100C17c)
obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_35475c

lopinavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_31781
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003011c

bromobenzenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3179
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0002452c

oxaliplatinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_31941
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3150C17c)
obo:RO_0000087op some obo:CHEBI_25435c

buprenorphinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3216
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:TXPO_0003665c
Sub-classes obo:TXPO_0004339c

Tolvaptanc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_32246
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3186C17c)

amineptinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_32499
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3219C17c)
obo:RO_0000087op some obo:CHEBI_51039c
obo:RO_0000087op some obo:CHEBI_35469c
Sub-classes obo:TXPO_0004361c

pirinixic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_32509
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0000122c

lysophosphatidic acidsc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_32957
Super-classes obo:CHEBI_16961c
Sub-classes obo:CHEBI_132742c
obo:CHEBI_60815c

long-chain fatty acyl-CoAc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33184
Super-classes obo:CHEBI_37554c

antitubercular agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33231
Super-classes obo:CHEBI_64912c

atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33250
Super-classes obo:CHEBI_24431c
Sub-classes obo:TXPO_0003128c
obo:CHEBI_25555c
obo:CHEBI_22984c
obo:CHEBI_25805c
obo:CHEBI_27594c
obo:CHEBI_18248c
obo:CHEBI_33521c
obo:CHEBI_26833c
obo:CHEBI_49637c

molecular messengerc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33280
Super-classes obo:CHEBI_24432c
obo:TXPO_0001393c
Sub-classes obo:CHEBI_24621c
obo:TXPO_0000564c
obo:TXPO_0000622c
obo:TXPO_0003686c
obo:TXPO_0002401c
obo:TXPO_0001898c
obo:CHEBI_25512c

antimicrobial agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33281
Super-classes obo:CHEBI_52210c
obo:CHEBI_24432c
Sub-classes obo:CHEBI_22587c
obo:CHEBI_33282c
obo:CHEBI_36043c
obo:CHEBI_35718c
obo:CHEBI_36044c

antibacterial agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33282
Super-classes obo:CHEBI_33281c
Sub-classes obo:CHEBI_36047c

food rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33290
Super-classes obo:CHEBI_24432c

metal atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33521
Super-classes obo:CHEBI_33250c
Sub-classes obo:CHEBI_22314c

biomacromoleculec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33694
Super-classes obo:CHEBI_36357c
Sub-classes obo:CHEBI_6495c
obo:CHEBI_18154c
obo:CHEBI_36080c
obo:CHEBI_15986c

nucleic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33696
Super-classes obo:CHEBI_15986c
Sub-classes obo:CHEBI_16991c
obo:CHEBI_33697c

ribonucleic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33697
Super-classes obo:CHEBI_33696c

amino acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33709
Description

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Super-classes obo:CHEBI_72695c
Sub-classes obo:IMR_0200272c
obo:IMR_0200428c
obo:IMR_0200240c
obo:IMR_0100043c
obo:IMR_0200113c
obo:IMR_0100118c
obo:IMR_0200342c
obo:IMR_0200459c
obo:IMR_0100119c
obo:IMR_0200290c
obo:IMR_0200453c
obo:IMR_0200251c
obo:IMR_0200307c
obo:IMR_0200137c
obo:IMR_0100044c
obo:IMR_0100117c
obo:IMR_0200448c
obo:IMR_0200140c
obo:IMR_0200274c
obo:IMR_0100120c
obo:IMR_0200467c
obo:IMR_0200183c
obo:IMR_0200492c
obo:IMR_0200488c
obo:IMR_0200501c
obo:IMR_0200154c

nucleosidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33838
Super-classes obo:IMR_0001698c
obo:CHEBI_72695c
Sub-classes obo:CHEBI_16335c
obo:CHEBI_16750c

phenolsc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_33853
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0000591c

carbamazepinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3387
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_61115c
obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_35623c
obo:RO_0000087op some obo:CHEBI_35480c
obo:RO_0000087op some obo:CHEBI_88188c
obo:RO_0000087op some obo:CHEBI_52290c
obo:RO_0000087op some obo:CHEBI_64370c
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_38633c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3369C17c)
obo:RO_0000087op some obo:CHEBI_35477c

benzaronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_34559
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3427C17c)

N-nitrosodiethylaminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_34873
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004704c

antimetabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35221
Super-classes obo:CHEBI_52206c
Sub-classes obo:CHEBI_73913c

inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35222
Super-classes obo:CHEBI_24432c
obo:TXPO_0003710c
Sub-classes obo:CHEBI_23924c
obo:CHEBI_73240c
obo:CHEBI_83317c
obo:TXPO_0003989c

catalystc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35223
Super-classes obo:CHEBI_51086c

central nervous system stimulantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35337
Super-classes obo:CHEBI_35470c

steroidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35341
Super-classes obo:CHEBI_18059c
Sub-classes obo:CHEBI_16113c
obo:CHEBI_791c
obo:CHEBI_23965c
obo:CHEBI_17263c
obo:TXPO_0000509c

monosaccharidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35381
Super-classes obo:CHEBI_16646c
Sub-classes obo:CHEBI_17234c
obo:CHEBI_28757c

antiinfective agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35441
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_35442c
obo:CHEBI_36043c

antiparasitic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35442
Super-classes obo:CHEBI_35441c
Sub-classes obo:CHEBI_35443c
obo:CHEBI_64915c
obo:CHEBI_35820c

anthelminthic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35443
Super-classes obo:CHEBI_35442c
Sub-classes obo:CHEBI_35444c

antinematodal drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35444
Super-classes obo:CHEBI_25491c
obo:CHEBI_35443c

antidepressantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35469
Super-classes obo:CHEBI_35471c

central nervous system drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35470
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_35488c
obo:CHEBI_35337c
obo:CHEBI_35471c

psychotropic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35471
Super-classes obo:CHEBI_35470c
Sub-classes obo:CHEBI_137736c
obo:CHEBI_35473c
obo:CHEBI_35469c

anti-inflammatory drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35472
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_35475c

tranquilizing drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35473
Super-classes obo:CHEBI_35488c
obo:CHEBI_35471c
Sub-classes obo:CHEBI_35474c
obo:CHEBI_35476c
obo:CHEBI_35477c

anxiolytic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35474
Super-classes obo:CHEBI_35473c

non-steroidal anti-inflammatory drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35475
Super-classes obo:CHEBI_35842c
obo:CHEBI_35472c

antipsychotic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35476
Super-classes obo:CHEBI_35473c
Sub-classes obo:CHEBI_65191c

antimanic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35477
Super-classes obo:CHEBI_35473c

analgesicc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35480
Super-classes obo:CHEBI_52210c
obo:CHEBI_23888c
Sub-classes obo:CHEBI_35481c
obo:TXPO_0003665c

non-narcotic analgesicc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35481
Super-classes obo:CHEBI_35480c

EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35487
Super-classes obo:CHEBI_76852c

central nervous system depressantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35488
Super-classes obo:CHEBI_35470c
Sub-classes obo:CHEBI_35473c
obo:CHEBI_35717c
obo:TXPO_0003653c
obo:CHEBI_35623c

antipyreticc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35493
Super-classes obo:CHEBI_23888c

androgen antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35497
Super-classes obo:CHEBI_49020c
obo:CHEBI_23888c

diureticc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35498
Super-classes obo:CHEBI_23888c

hypoglycemic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35526
Super-classes obo:CHEBI_23888c

beta-adrenergic antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35530
Super-classes obo:CHEBI_37887c
obo:CHEBI_48540c

EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35544
Super-classes obo:CHEBI_76840c
Sub-classes obo:CHEBI_50629c
obo:CHEBI_50630c

Perfluorooctanoic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35549
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004537c

perhexilinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35553
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL3720C17c)
obo:RO_0000087op some obo:CHEBI_35554c
Sub-classes obo:TXPO_0002013c
obo:TXPO_0004330c

cardiovascular drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35554
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_35620c
obo:CHEBI_38070c
obo:CHEBI_38147c
obo:CHEBI_35674c
obo:CHEBI_50514c

alpha-adrenergic agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35569
Super-classes obo:CHEBI_48539c
obo:CHEBI_37886c

phoronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35572
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0001924c

antineoplastic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35610
Super-classes obo:CHEBI_23888c

vasodilator agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35620
Super-classes obo:CHEBI_35554c

anticonvulsantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35623
Super-classes obo:CHEBI_35488c

EC 1.17.3.2 (xanthine oxidase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35634
Super-classes obo:CHEBI_76850c

adrenergic uptake inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35640
Super-classes obo:CHEBI_37962c

HIV protease inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35660
Super-classes obo:CHEBI_36044c
obo:CHEBI_64946c
obo:CHEBI_37670c

antihypertensive agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35674
Super-classes obo:CHEBI_35554c

antilipemic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35679
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_35821c

xenobioticc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35703
Super-classes obo:CHEBI_24432c

immunosuppressive agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35705
Super-classes obo:CHEBI_50846c

sedativec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35717
Super-classes obo:CHEBI_35488c

antifungal agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35718
Super-classes obo:CHEBI_33281c
Sub-classes obo:CHEBI_24127c
obo:CHEBI_86327c

glycerolipidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35741
Super-classes obo:CHEBI_18059c
Sub-classes obo:IMR_0100027c
obo:CHEBI_37739c

glycerophosphoserinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35766
Super-classes obo:CHEBI_37739c
Sub-classes obo:CHEBI_18303c

phosphosphingolipidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35786
Super-classes obo:CHEBI_16247c
obo:CHEBI_26739c
Sub-classes obo:CHEBI_37550c
obo:CHEBI_64583c

leprostatic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35816
Super-classes obo:CHEBI_64912c

antiprotozoal drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35820
Super-classes obo:CHEBI_36043c
obo:CHEBI_35442c
Sub-classes obo:CHEBI_36335c
obo:CHEBI_64915c

anticholesteremic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35821
Super-classes obo:CHEBI_35679c

uricosuric drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35841
Super-classes obo:CHEBI_35845c
obo:CHEBI_35846c

antirheumatic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35842
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_35845c
obo:CHEBI_35475c

gout suppressantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35845
Super-classes obo:CHEBI_35842c
Sub-classes obo:CHEBI_35841c

renal agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35846
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_35841c

lipoxygenase inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35856
Super-classes obo:CHEBI_76837c
Sub-classes obo:CHEBI_64964c

neurotransmitter agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_35942
Super-classes obo:CHEBI_23888c
obo:CHEBI_52210c
Sub-classes obo:CHEBI_51374c
obo:CHEBI_37962c
obo:CHEBI_48560c
obo:CHEBI_64371c
obo:CHEBI_38323c
obo:CHEBI_48278c
obo:CHEBI_37957c

antimicrobial drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36043
Super-classes obo:CHEBI_33281c
obo:CHEBI_35441c
Sub-classes obo:CHEBI_36044c
obo:CHEBI_35820c
obo:CHEBI_36047c

antiviral drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36044
Super-classes obo:CHEBI_36043c
obo:CHEBI_33281c
obo:CHEBI_22587c
Sub-classes obo:CHEBI_35660c
obo:CHEBI_59886c

antibacterial drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36047
Super-classes obo:CHEBI_33282c
obo:CHEBI_36043c
Sub-classes obo:CHEBI_64912c

proteinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36080
Super-classes obo:CHEBI_16670c
obo:CHEBI_33694c

chlormezanonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3619
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35474c
obo:RO_0000087op some obo:CHEBI_51371c
obo:RO_0000087op some obo:CHEBI_35476c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4000C17c)

glycerophosphoethanolaminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36314
Super-classes obo:CHEBI_37739c
obo:CHEBI_36711c
Sub-classes obo:CHEBI_16038c

glycerophosphoinositolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36315
Super-classes obo:CHEBI_37739c
Sub-classes obo:CHEBI_28874c

trypanocidal drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36335
Super-classes obo:CHEBI_35820c

polyatomic entityc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36357
Super-classes obo:CHEBI_23367c
Sub-classes obo:CHEBI_33694c

dichloroacetic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36386
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004674c

anabolic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36413
Super-classes obo:CHEBI_24621c

chlorpromazinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3647
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0000499c

chlorzoxazonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3655
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_51371c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4084C17c)
obo:RO_0000087op some obo:CHEBI_35717c

phosphoethanolaminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36711
Super-classes obo:CHEBI_25710c
Sub-classes obo:CHEBI_36314c

darunavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_367163
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_36044c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4120C17c)
obo:RO_0000087op some obo:CHEBI_35660c

duloxetinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36796
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_76779c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4146C17c)

nucleotidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_36976
Super-classes obo:CHEBI_72695c
obo:IMR_0001698c
Sub-classes obo:CHEBI_15996c
obo:CHEBI_16474c
obo:CHEBI_13389c
obo:CHEBI_16761c
obo:CHEBI_15422c
obo:IMR_0001355c
obo:IMR_0001357c
obo:IMR_0200292c

EC 3.1.3.16 (phosphoprotein phosphatase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37153
Super-classes obo:CHEBI_76775c

clarithromycinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3732
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_36047c
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35703c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4200C17c)
obo:RO_0000087op some obo:CHEBI_48001c

phosphatidylinositol bisphosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37328
Super-classes obo:CHEBI_28765c
Sub-classes obo:CHEBI_16152c
obo:CHEBI_18348c

clofibratec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3750
Super-classes obo:TXPO_1000442c
Restrictions obo:RO_0000087op some obo:CHEBI_35679c
obo:RO_0000087op some obo:CHEBI_35821c
Sub-classes obo:TXPO_0001897c
obo:TXPO_0004567c

acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37527
Super-classes obo:CHEBI_51086c
Sub-classes obo:CHEBI_59739c

sphingosine-1-phosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37550
Description

Sphingolipid mediators, such as sphingosine 1-phosphate (S1P), ceramide, and sphingosine are derived by the enzymatic breakdown of sphingomyelin, an abundant membrane phospholipid. S1P is an evolutionarily conserved bioactive lipid mediator with potent effects on multiple organ systems.
Super-classes obo:CHEBI_35786c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c
obo:RO_0000087op some obo:TXPO_0003686c
Sub-classes obo:TXPO_0003349c
obo:TXPO_0001609c
obo:TXPO_0003570c

fatty acyl-CoAc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37554
Super-classes obo:CHEBI_61697c
Sub-classes obo:CHEBI_33184c
obo:CHEBI_61910c
obo:CHEBI_51006c

clozapinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_3766
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_48279c
obo:RO_0000087op some obo:CHEBI_37956c
obo:RO_0000087op some obo:CHEBI_48561c
obo:RO_0000087op some obo:CHEBI_65259c
obo:RO_0000087op some obo:CHEBI_48876c
obo:RO_0000087op some obo:CHEBI_37887c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4318C17c)
obo:RO_0000087op some obo:CHEBI_65191c
obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_76779c
obo:RO_0000087op some obo:CHEBI_78298c

protease inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37670
Super-classes obo:CHEBI_60258c
Sub-classes obo:CHEBI_64926c
obo:CHEBI_35660c

protein kinase inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37699
Super-classes obo:CHEBI_76668c
Sub-classes obo:CHEBI_38637c
obo:CHEBI_76812c
obo:CHEBI_76817c
obo:CHEBI_74440c

EC 2.7.11.13 (protein kinase C) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37700
Super-classes obo:CHEBI_76812c

EC 3.1.1.8 (cholinesterase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37733
Super-classes obo:CHEBI_76773c

phosphoric esterc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37734
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0002623c

glycerophospholipidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37739
Super-classes obo:CHEBI_35741c
obo:CHEBI_16247c
Sub-classes obo:CHEBI_36315c
obo:CHEBI_137209c
obo:CHEBI_16337c
obo:CHEBI_24360c
obo:CHEBI_36314c
obo:CHEBI_28494c
obo:CHEBI_16961c
obo:CHEBI_35766c

growth hormonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37845
Super-classes obo:CHEBI_24621c

adrenergic agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37886
Super-classes obo:CHEBI_37962c
Sub-classes obo:CHEBI_35569c

adrenergic antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37887
Super-classes obo:CHEBI_37962c
Sub-classes obo:CHEBI_35530c
obo:CHEBI_37890c

alpha-adrenergic antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37890
Super-classes obo:CHEBI_48539c
obo:CHEBI_37887c

atazanavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37924
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35660c
obo:RO_0000087op some obo:CHEBI_36044c
Sub-classes obo:TXPO_0003024c

histamine antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37956
Super-classes obo:CHEBI_48706c
obo:CHEBI_37957c

histaminergic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37957
Super-classes obo:CHEBI_35942c
Sub-classes obo:CHEBI_37956c

adrenergic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_37962
Super-classes obo:CHEBI_35942c
Sub-classes obo:CHEBI_66991c
obo:CHEBI_37887c
obo:CHEBI_35640c
obo:CHEBI_48540c
obo:CHEBI_48539c
obo:CHEBI_37886c

antimalarialc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38068
Super-classes obo:CHEBI_64915c

anti-arrhythmia drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38070
Super-classes obo:CHEBI_35554c

cardiotonic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38147
Super-classes obo:CHEBI_35554c

iron chelatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38157
Super-classes obo:CHEBI_38161c

chelatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38161
Super-classes obo:CHEBI_52214c
obo:CHEBI_51086c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
Sub-classes obo:CHEBI_38157c

Methapyrilene hydrochloridec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38213
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50857c
obo:RO_0000087op some obo:CHEBI_35717c
Sub-classes obo:TXPO_0004969c

Monuronc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38214
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0005008c

calcium channel blockerc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38215
Super-classes obo:CHEBI_38808c

fumonisin B1c # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38221
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004516c

DNA polymerase inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38234
Super-classes obo:CHEBI_76815c
Sub-classes obo:CHEBI_59897c

cholinergic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38323
Super-classes obo:CHEBI_35942c
Sub-classes obo:CHEBI_48873c

acetylcholinesterase inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38462
Super-classes obo:CHEBI_76759c

electron-transport chain inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38496
Super-classes obo:CHEBI_76932c
Sub-classes obo:CHEBI_38497c

respiratory-chain inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38497
Super-classes obo:CHEBI_38496c
Sub-classes obo:CHEBI_25355c
obo:CHEBI_38503c

EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38503
Super-classes obo:CHEBI_76866c
obo:CHEBI_38497c

membrane transport modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38632
Super-classes obo:CHEBI_52208c
obo:TXPO_0003230c
Sub-classes obo:CHEBI_38808c
obo:CHEBI_64371c
obo:CHEBI_39000c
obo:CHEBI_50510c

sodium channel blockerc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38633
Super-classes obo:CHEBI_39000c

tyrosine kinase inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38637
Super-classes obo:CHEBI_37699c
Sub-classes obo:CHEBI_62434c

calcium channel agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38807
Super-classes obo:CHEBI_38808c

calcium channel modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38808
Super-classes obo:CHEBI_38632c
Sub-classes obo:CHEBI_38215c
obo:CHEBI_38807c
obo:CHEBI_38809c

ryanodine receptor modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38809
Super-classes obo:CHEBI_38808c
Sub-classes obo:CHEBI_67114c

sunitinibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_38940
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_48422c
obo:RO_0000087op some obo:CHEBI_65207c
obo:RO_0000087op some obo:CHEBI_63726c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4658C17c)
obo:RO_0000087op some obo:CHEBI_62434c
obo:RO_0000087op some obo:CHEBI_50846c
obo:RO_0000087op some obo:CHEBI_35610c

sodium channel modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39000
Super-classes obo:CHEBI_38632c
Sub-classes obo:CHEBI_38633c

high-density lipoproteinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39025
Super-classes obo:CHEBI_6495c

very-low-density lipoproteinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39027
Super-classes obo:CHEBI_6495c
Sub-classes obo:TXPO_0001351c

pyrethrinsc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39098
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004971c

calcium cationc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39123
Super-classes obo:CHEBI_39124c

calcium ionc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39124
Super-classes obo:TXPO_0000052c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c
Sub-classes obo:CHEBI_39123c

atorvastatinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39548
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4733C17c)
obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_78298c

diflunisalc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39669
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35481c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4764C17c)
obo:RO_0000087op some obo:CHEBI_35475c

valproic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_39867
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_61115c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4817C17c)
obo:RO_0000087op some obo:CHEBI_35623c
obo:RO_0000087op some obo:CHEBI_35477c
obo:RO_0000087op some obo:CHEBI_51374c
obo:RO_0000087op some obo:CHEBI_35471c
obo:RO_0000087op some obo:CHEBI_50905c
obo:RO_0000087op some obo:CHEBI_63726c
Sub-classes obo:TXPO_0004358c
obo:TXPO_0000788c

allopurinolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_40279
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35845c
obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_35634c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4856C17c)
obo:RO_0000087op some obo:CHEBI_48578c

cyclosporin Ac # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4031
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003132c

tamoxifenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_41774
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50837c
obo:RO_0000087op some obo:CHEBI_37700c
obo:RO_0000087op some obo:CHEBI_48422c
obo:RO_0000087op some obo:CHEBI_50739c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4923C17c)
obo:RO_0000087op some obo:CHEBI_50792c
obo:RO_0000087op some obo:CHEBI_62872c
obo:RO_0000087op some obo:CHEBI_50646c
obo:RO_0000087op some obo:CHEBI_35610c
Sub-classes obo:TXPO_0000319c
obo:TXPO_0000313c
obo:TXPO_0000787c
obo:TXPO_0004335c

abacavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_421707
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_53756c
obo:RO_0000087op some obo:CHEBI_88188c
obo:RO_0000087op some obo:CHEBI_36044c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL4958C17c)

erythromycin Ac # Classes

URI http://purl.obolibrary.org/obo/CHEBI_42355
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_33281c

dacarbazinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4305
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_22333c
obo:RO_0000087op some obo:CHEBI_50266c
obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5010C17c)
obo:RO_0000087op some obo:CHEBI_50903c

danazolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4315
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50751c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5040C17c)
obo:RO_0000087op some obo:CHEBI_50837c

dantrolenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4317
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5067C17c)
obo:RO_0000087op some obo:CHEBI_51371c

indinavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_44032
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35660c

methotrexatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_44185
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35842c
obo:RO_0000087op some obo:CHEBI_50177c
obo:RO_0000087op some obo:CHEBI_50683c
obo:RO_0000087op some obo:CHEBI_35705c
obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_59517c
obo:RO_0000087op some obo:CHEBI_50691c
obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5134C17c)

dermatanc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4439
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5156C17c)

hydroxyureac # Classes

URI http://purl.obolibrary.org/obo/CHEBI_44423
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50846c
obo:RO_0000087op some obo:CHEBI_50905c
obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5215C17c)
obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_74213c
obo:RO_0000087op some obo:CHEBI_48578c
obo:RO_0000087op some obo:CHEBI_50902c
obo:RO_0000087op some obo:CHEBI_59517c
obo:RO_0000087op some obo:CHEBI_64911c

nimesulidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_44445
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50629c
obo:RO_0000087op some obo:CHEBI_35475c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5248C17c)
Sub-classes obo:TXPO_0004354c
obo:TXPO_0002042c

rifapentinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_45304
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_33231c
obo:RO_0000087op some obo:CHEBI_35816c

ritonavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_45409
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35703c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5304C17c)
obo:RO_0000087op some obo:CHEBI_36044c
obo:RO_0000087op some obo:CHEBI_35660c
obo:RO_0000087op some obo:CHEBI_78298c

imatinibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_45783
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_38637c
obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5339C17c)
obo:RO_0000087op some obo:CHEBI_68495c

thiabendazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_45979
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35444c
obo:RO_0000087op some obo:CHEBI_86328c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5370C17c)

tacrinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_45980
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_38462c
Sub-classes obo:TXPO_0004365c

fluconazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_46081
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35703c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5419C17c)
obo:RO_0000087op some obo:CHEBI_50183c
obo:RO_0000087op some obo:CHEBI_78298c

paracetamolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_46195
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5447C17c)
obo:RO_0000087op some obo:CHEBI_35475c
Sub-classes obo:TXPO_0004331c
obo:TXPO_0001922c

disulfiramc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4659
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_37733c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5508C17c)
obo:RO_0000087op some obo:CHEBI_73240c
obo:RO_0000087op some obo:CHEBI_78444c
obo:RO_0000087op some obo:CHEBI_50276c
obo:RO_0000087op some obo:CHEBI_24127c
obo:RO_0000087op some obo:CHEBI_35487c
obo:RO_0000087op some obo:CHEBI_68495c
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_48422c
Sub-classes obo:TXPO_0004334c

solventc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_46787
Super-classes obo:CHEBI_51086c

diclofenacc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_47381
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5568C17c)
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_35544c
obo:RO_0000087op some obo:CHEBI_88188c
obo:RO_0000087op some obo:CHEBI_35493c
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_35481c
Sub-classes obo:TXPO_0004353c

caspofunginc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_474180
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35441c

imipraminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_47499
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003228c
obo:TXPO_0001560c
obo:TXPO_0003225c

ketoconazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_47519
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5614C17c)

clomipraminec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_47780
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_48278c
obo:RO_0000087op some obo:CHEBI_77402c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5658C17c)
obo:RO_0000087op some obo:CHEBI_35469c
obo:RO_0000087op some obo:CHEBI_50949c
obo:RO_0000087op some obo:CHEBI_48279c
Sub-classes obo:TXPO_0000081c

photosensitizing agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_47868
Super-classes obo:CHEBI_23888c

protein synthesis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48001
Super-classes obo:CHEBI_76932c
Restrictions obo:RO_0002599op some obo:TXPO_0000382c

serotonergic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48278
Super-classes obo:CHEBI_35942c
Sub-classes obo:CHEBI_48279c
obo:CHEBI_50949c

serotonergic antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48279
Super-classes obo:CHEBI_48278c

EC 2.1.1.6 (catechol O-methyltransferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48406
Super-classes obo:CHEBI_76871c

antiparkinson drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48407
Super-classes obo:CHEBI_23888c
obo:CHEBI_66956c

angiogenesis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48422
Super-classes obo:CHEBI_23888c

erythromycin estolatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4846
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_33281c
Sub-classes obo:TXPO_0003131c

alpha-adrenergic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48539
Super-classes obo:CHEBI_37962c
Sub-classes obo:CHEBI_35569c
obo:CHEBI_37890c

beta-adrenergic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48540
Super-classes obo:CHEBI_37962c
Sub-classes obo:CHEBI_35530c

tolrestatc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48549
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5771C17c)
obo:RO_0000087op some obo:CHEBI_48550c

EC 1.1.1.21 (aldehyde reductase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48550
Super-classes obo:CHEBI_76835c

dopaminergic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48560
Super-classes obo:CHEBI_35942c
Sub-classes obo:CHEBI_48561c
obo:CHEBI_51039c

dopaminergic antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48561
Super-classes obo:CHEBI_48560c

radical scavengerc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48578
Super-classes obo:CHEBI_22586c

fibrin modulating drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48676
Super-classes obo:CHEBI_23888c

estramustinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4868
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_66987c
obo:RO_0000087op some obo:CHEBI_22333c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5846C17c)

agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48705
Super-classes obo:CHEBI_52210c
Sub-classes obo:CHEBI_24621c
obo:CHEBI_85012c
obo:CHEBI_50864c
obo:CHEBI_71554c
obo:CHEBI_63951c
obo:CHEBI_132972c
obo:CHEBI_64106c
obo:CHEBI_70782c
obo:CHEBI_72768c
obo:CHEBI_77326c

antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48706
Super-classes obo:CHEBI_52210c
Sub-classes obo:CHEBI_37956c
obo:CHEBI_65259c
obo:CHEBI_74440c
obo:CHEBI_50792c
obo:CHEBI_67199c
obo:CHEBI_91079c
obo:CHEBI_65207c
obo:CHEBI_63673c
obo:CHEBI_49020c
obo:CHEBI_76998c
obo:CHEBI_60798c

ethambutolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4877
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_33231c
obo:RO_0000087op some obo:CHEBI_35703c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5899C17c)
obo:RO_0000087op some obo:CHEBI_78298c

ethionamidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4885
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:TXPO_0001996c
obo:RO_0000087op some obo:CHEBI_50185c

cholinergic antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48873
Super-classes obo:CHEBI_38323c
Sub-classes obo:CHEBI_48876c

muscarinic antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48876
Super-classes obo:CHEBI_48873c

bile acid metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48887
Super-classes obo:CHEBI_25212c

erythromycinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_48923
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_78298c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL5973C17c)
obo:RO_0000087op some obo:CHEBI_76969c
obo:RO_0000087op some obo:CHEBI_35703c

deferasiroxc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49005
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6000C17c)
obo:RO_0000087op some obo:CHEBI_38157c

hormone antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49020
Super-classes obo:CHEBI_48706c
obo:CHEBI_51061c
Sub-classes obo:CHEBI_51451c
obo:CHEBI_49159c
obo:CHEBI_35497c
obo:CHEBI_50671c
obo:CHEBI_50837c

didanosinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_490877
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_63090c
obo:RO_0000087op some obo:CHEBI_36044c
obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_53756c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6049C17c)
Sub-classes obo:TXPO_0004386c

etodolacc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4909
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_35493c
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_50629c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6088C17c)

drug metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49103
Super-classes obo:CHEBI_76967c

leukotriene antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49159
Super-classes obo:CHEBI_49020c

anti-asthmatic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49167
Super-classes obo:CHEBI_65023c
obo:CHEBI_23888c

anti-ulcer drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49201
Super-classes obo:CHEBI_23888c

contraceptive drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49323
Super-classes obo:CHEBI_50689c
Sub-classes obo:CHEBI_49324c

female contraceptive drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49324
Super-classes obo:CHEBI_49323c

exemestanec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4953
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_78298c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6174C17c)
obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_50790c

lapatinibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49603
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6204C17c)
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_38637c

hydrogen atomc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49637
Super-classes obo:CHEBI_33250c

gefitinibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_49668
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6241C17c)
obo:RO_0000087op some obo:CHEBI_74440c

felbamatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_4995
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6272C17c)
obo:RO_0000087op some obo:CHEBI_63726c
obo:RO_0000087op some obo:CHEBI_35623c

fenofibratec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5001
Super-classes obo:TXPO_1000442c
Sub-classes obo:TXPO_0001895c

fenoprofenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5004
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50629c
obo:RO_0000087op some obo:CHEBI_35475c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6328C17c)
obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_88188c
obo:RO_0000087op some obo:CHEBI_50630c
obo:RO_0000087op some obo:CHEBI_35493c

sex hormonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50112
Super-classes obo:CHEBI_24621c
Sub-classes obo:CHEBI_50113c
obo:CHEBI_50114c
obo:CHEBI_50745c

androgenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50113
Super-classes obo:CHEBI_50112c

estrogenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50114
Super-classes obo:CHEBI_50112c

rosiglitazonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50122
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0002720c

acitretinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50172
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6382C17c)

keratolytic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50176
Super-classes obo:CHEBI_50177c

dermatologic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50177
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_50176c
obo:CHEBI_50748c

P450 inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50183
Super-classes obo:CHEBI_76725c
obo:CHEBI_76898c
Restrictions obo:RO_0002599op some obo:TXPO_0001758c

fatty acid synthesis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50185
Super-classes obo:TXPO_0003648c
Restrictions obo:RO_0002599op some obo:GO_0006633c

hematologic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50248
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_50249c
obo:CHEBI_50427c

anticoagulantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50249
Super-classes obo:CHEBI_50248c

prodrugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50266
Super-classes obo:CHEBI_23888c

protective agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50267
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_63726c
obo:CHEBI_66987c

EC 5.99.1.2 (DNA topoisomerase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50276
Super-classes obo:CHEBI_70727c

platelet aggregation inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50427
Super-classes obo:CHEBI_50248c

phospholipase A2 inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50469
Super-classes obo:CHEBI_76759c

EC 2.5.1.15 (dihydropteroate synthase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50502
Super-classes obo:CHEBI_76663c

potassium channel modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50510
Super-classes obo:CHEBI_38632c

vasoconstrictor agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50514
Super-classes obo:CHEBI_35554c

EC 3.2.1.1 (alpha-amylase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50627
Super-classes obo:CHEBI_52424c

cyclooxygenase 2 inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50629
Super-classes obo:CHEBI_35544c

cyclooxygenase 1 inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50630
Super-classes obo:CHEBI_35544c

bone density conservation agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50646
Super-classes obo:CHEBI_23888c

antithyroid drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50671
Super-classes obo:CHEBI_49020c

methimazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50673
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50671c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6562C17c)

EC 1.5.1.3 (dihydrofolate reductase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50683
Super-classes obo:CHEBI_76863c
obo:CHEBI_73913c

reproductive control drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50689
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_66993c
obo:CHEBI_49323c
obo:CHEBI_50691c

abortifacientc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50691
Super-classes obo:CHEBI_50689c

minocyclinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50694
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6617C17c)
obo:RO_0000087op some obo:CHEBI_36047c
obo:RO_0000087op some obo:CHEBI_76971c

estrogen receptor modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50739
Super-classes obo:CHEBI_23888c

cyproterone acetatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50743
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004504c

progestogenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50745
Super-classes obo:CHEBI_50112c
Sub-classes obo:CHEBI_59826c

antipsoriaticc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50748
Super-classes obo:CHEBI_50177c

EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50750
Super-classes obo:CHEBI_70727c

anti-estrogenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50751
Super-classes obo:CHEBI_23888c

etonogestrelc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50777
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_49323c
obo:RO_0000087op some obo:CHEBI_49324c
obo:RO_0000087op some obo:CHEBI_59826c

EC 1.14.14.14 (aromatase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50790
Super-classes obo:CHEBI_76838c

estrogen receptor antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50792
Super-classes obo:CHEBI_48706c

estrogen antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50837
Super-classes obo:CHEBI_49020c

immunomodulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50846
Super-classes obo:CHEBI_23888c
obo:CHEBI_24432c
Sub-classes obo:CHEBI_35705c

anti-allergic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50857
Super-classes obo:CHEBI_23888c

bexarotenec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50859
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6751C17c)
obo:RO_0000087op some obo:CHEBI_35610c

organic molecular entityc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50860
Super-classes obo:CHEBI_24431c
Sub-classes obo:TXPO_0004819c
obo:CHEBI_4315c
obo:CHEBI_16646c
obo:CHEBI_5004c
obo:CHEBI_4659c
obo:CHEBI_135649c
obo:CHEBI_31183c
obo:CHEBI_38221c
obo:CHEBI_3655c
obo:CHEBI_4846c
obo:CHEBI_63589c
obo:CHEBI_10110c
obo:TXPO_0005179c
obo:CHEBI_47780c
obo:CHEBI_22693c
obo:CHEBI_135774c
obo:CHEBI_233869c
obo:CHEBI_33853c
obo:CHEBI_6717c
obo:CHEBI_46081c
obo:CHEBI_134728c
obo:CHEBI_135814c
obo:CHEBI_40279c
obo:TXPO_1000069c
obo:TXPO_1000327c
obo:CHEBI_16990c
obo:CHEBI_490877c
obo:CHEBI_3179c
obo:CHEBI_39669c
obo:TXPO_0005162c
obo:CHEBI_51450c
obo:CHEBI_4877c
obo:CHEBI_50122c
obo:CHEBI_28241c
obo:CHEBI_34559c
obo:TXPO_0005159c
obo:CHEBI_9352c
obo:TXPO_0005157c
obo:CHEBI_149836c
obo:TXPO_0005145c
obo:CHEBI_27779c
obo:CHEBI_31781c
obo:CHEBI_10112c
obo:CHEBI_63628c
obo:CHEBI_50743c
obo:CHEBI_39548c
obo:CHEBI_134965c
obo:CHEBI_45304c
obo:TXPO_0005172c
obo:CHEBI_2666c
obo:CHEBI_575568c
obo:TXPO_0005174c
obo:CHEBI_44423c
obo:CHEBI_9337c
obo:TXPO_0005147c
obo:CHEBI_135829c
obo:CHEBI_38940c
obo:CHEBI_7496c
obo:TXPO_0005177c
obo:TXPO_0005149c
obo:CHEBI_38214c
obo:CHEBI_119486c
obo:CHEBI_31446c
obo:CHEBI_135358c
obo:CHEBI_2376c
obo:TXPO_0005184c
obo:CHEBI_135009c
obo:TXPO_0005169c
obo:CHEBI_45783c
obo:CHEBI_4305c
obo:CHEBI_29688c
obo:TXPO_0005146c
obo:CHEBI_32246c
obo:CHEBI_35572c
obo:CHEBI_142468c
obo:CHEBI_114785c
obo:CHEBI_38213c
obo:CHEBI_681569c
obo:CHEBI_27690c
obo:TXPO_0005186c
obo:CHEBI_4909c
obo:CHEBI_17907c
obo:CHEBI_5958c
obo:CHEBI_64355c
obo:CHEBI_7820c
obo:CHEBI_4439c
obo:CHEBI_63613c
obo:CHEBI_6067c
obo:CHEBI_22271c
obo:CHEBI_49603c
obo:CHEBI_36796c
obo:TXPO_0005176c
obo:CHEBI_7573c
obo:CHEBI_17833c
obo:TXPO_0005183c
obo:CHEBI_5165c
obo:CHEBI_32509c
obo:TXPO_0005181c
obo:CHEBI_421707c
obo:CHEBI_3216c
obo:NCIT_C1029c
obo:CHEBI_75142c
obo:TXPO_0005148c
obo:CHEBI_6741c
obo:CHEBI_61697c
obo:CHEBI_17478c
obo:CHEBI_68508c
obo:CHEBI_48549c
obo:CHEBI_100241c
obo:CHEBI_50694c
obo:CHEBI_175901c
obo:CHEBI_8863c
obo:CHEBI_63630c
obo:CHEBI_28794c
obo:CHEBI_37734c
obo:TXPO_0005168c
obo:CHEBI_71415c
obo:TXPO_0005167c
obo:CHEBI_474180c
obo:CHEBI_135641c
obo:CHEBI_63581c
obo:CHEBI_10100c
obo:TXPO_0005166c
obo:CHEBI_45980c
obo:CHEBI_63598c
obo:CHEBI_18059c
obo:CHEBI_50172c
obo:CHEBI_47499c
obo:CHEBI_7494c
obo:CHEBI_28877c
obo:CHEBI_55346c
obo:CHEBI_6030c
obo:CHEBI_63924c
obo:CHEBI_7466c
obo:CHEBI_28680c
obo:TXPO_0005173c
obo:CHEBI_134762c
obo:CHEBI_9516c
obo:CHEBI_6402c
obo:CHEBI_25710c
obo:CHEBI_39098c
obo:CHEBI_23995c
obo:CHEBI_4317c
obo:CHEBI_27226c
obo:CHEBI_39867c
obo:CHEBI_3647c
obo:CHEBI_5937c
obo:CHEBI_5938c
obo:CHEBI_5120c
obo:CHEBI_73044c
obo:CHEBI_127342c
obo:CHEBI_44185c
obo:CHEBI_16914c
obo:CHEBI_8107c
obo:CHEBI_3619c
obo:CHEBI_49668c
obo:CHEBI_3387c
obo:CHEBI_16602c
obo:CHEBI_31653c
obo:TXPO_0005182c
obo:TXPO_0005154c
obo:CHEBI_5441c
obo:CHEBI_76603c
obo:CHEBI_2663c
obo:CHEBI_6076c
obo:CHEBI_240107c
obo:CHEBI_254496c
obo:CHEBI_17855c
obo:CHEBI_35553c
obo:TXPO_0005156c
obo:CHEBI_9588c
obo:CHEBI_71219c
obo:CHEBI_47381c
obo:CHEBI_29699c
obo:CHEBI_4995c
obo:CHEBI_49005c
obo:CHEBI_76133c
obo:CHEBI_27902c
obo:TXPO_0005150c
obo:TXPO_0005161c
obo:TXPO_0005160c
obo:TXPO_0005171c
obo:TXPO_0005163c
obo:CHEBI_44032c
obo:CHEBI_28077c
obo:CHEBI_7640c
obo:CHEBI_94686c
obo:CHEBI_4953c
obo:CHEBI_5132c
obo:CHEBI_36386c
obo:CHEBI_35549c
obo:CHEBI_3090c
obo:CHEBI_50859c
obo:CHEBI_135005c
obo:CHEBI_135706c
obo:TXPO_0005165c
obo:CHEBI_101278c
obo:CHEBI_3766c
obo:TXPO_0005170c
obo:CHEBI_46195c
obo:CHEBI_134891c
obo:CHEBI_31941c
obo:CHEBI_63608c
obo:TXPO_1000442c
obo:CHEBI_47519c
obo:CHEBI_17747c
obo:CHEBI_34873c
obo:TXPO_0005180c
obo:CHEBI_17931c
obo:CHEBI_9763c
obo:CHEBI_17347c
obo:TXPO_0005158c
obo:CHEBI_135512c
obo:CHEBI_31257c
obo:CHEBI_16664c
obo:TXPO_0005153c
obo:CHEBI_50777c
obo:TXPO_0004970c
obo:CHEBI_3023c
obo:TXPO_1000172c
obo:CHEBI_42355c
obo:TXPO_0004972c
obo:CHEBI_37924c
obo:TXPO_0005144c
obo:TXPO_0005152c
obo:CHEBI_48923c
obo:CHEBI_50924c
obo:CHEBI_18320c
obo:CHEBI_367163c
obo:CHEBI_4031c
obo:CHEBI_7864c
obo:CHEBI_4868c
obo:CHEBI_50673c
obo:CHEBI_116225c
obo:CHEBI_135357c
obo:CHEBI_27385c
obo:CHEBI_6343c
obo:CHEBI_16755c
obo:CHEBI_45409c
obo:CHEBI_135273c
obo:CHEBI_5296c
obo:CHEBI_7953c
obo:CHEBI_65172c
obo:CHEBI_9334c
obo:CHEBI_9727c
obo:CHEBI_6916c
obo:CHEBI_85010c
obo:CHEBI_76114c
obo:CHEBI_28901c
obo:TXPO_0005175c
obo:CHEBI_63629c
obo:TXPO_0005185c
obo:CHEBI_41774c
obo:CHEBI_17356c
obo:CHEBI_3732c
obo:CHEBI_32499c
obo:CHEBI_45979c
obo:TXPO_0005155c
obo:CHEBI_2825c
obo:CHEBI_9448c
obo:TXPO_0005187c
obo:TXPO_0005164c
obo:CHEBI_2948c
obo:TXPO_0005178c
obo:CHEBI_28509c
obo:CHEBI_31596c
obo:CHEBI_10023c
obo:TXPO_0005151c
obo:CHEBI_52717c
obo:CHEBI_24783c
obo:TXPO_0005188c
obo:CHEBI_135666c
obo:CHEBI_44445c
obo:CHEBI_600520c
obo:CHEBI_4885c
obo:CHEBI_9753c
obo:CHEBI_76158c
obo:CHEBI_6367c
obo:CHEBI_30956c
obo:CHEBI_135028c
obo:CHEBI_5855c
obo:CHEBI_27136c

insulin-sensitizing drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50864
Super-classes obo:CHEBI_48705c

genotoxinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50902
Super-classes obo:CHEBI_52209c
obo:TXPO_0000038c
Sub-classes obo:CHEBI_25435c

carcinogenic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50903
Super-classes obo:CHEBI_52209c

allergenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50904
Super-classes obo:CHEBI_52209c
Sub-classes obo:CHEBI_88188c

teratogenic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50905
Super-classes obo:CHEBI_52209c

hepatotoxic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50908
Super-classes obo:TXPO_0000038c
obo:CHEBI_52209c
Sub-classes obo:CHEBI_83612c

cardiotoxic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50912
Super-classes obo:TXPO_0000038c

sorafenibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50924
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_38637c
obo:RO_0000087op some obo:CHEBI_50925c
obo:RO_0000087op some obo:CHEBI_36044c
obo:RO_0000087op some obo:CHEBI_48422c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6855C17c)
Sub-classes obo:TXPO_0003025c

EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50925
Super-classes obo:CHEBI_76812c
obo:CHEBI_23924c

angiogenesis modulating agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50926
Super-classes obo:CHEBI_23888c

serotonin uptake inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_50949
Super-classes obo:CHEBI_48278c

unsaturated fatty acyl-CoAc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51006
Super-classes obo:CHEBI_37554c

dopamine uptake inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51039
Super-classes obo:CHEBI_48560c

hormone receptor modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51061
Super-classes obo:CHEBI_23888c
obo:CHEBI_90710c
Sub-classes obo:CHEBI_49020c

chemical rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51086
Super-classes obo:BFO_0000023c
Sub-classes obo:CHEBI_64297c
obo:CHEBI_37527c
obo:CHEBI_38161c
obo:CHEBI_78298c
obo:CHEBI_63248c
obo:CHEBI_22695c
obo:CHEBI_52214c
obo:CHEBI_63247c
obo:TXPO_0003660c
obo:CHEBI_46787c
obo:CHEBI_22586c
obo:CHEBI_35223c

fluoxymesteronec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5120
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_36413c

flutamidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5132
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL6955C17c)
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_35497c

muscle relaxantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51371
Super-classes obo:CHEBI_51372c
Sub-classes obo:CHEBI_53784c

neuromuscular agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51372
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_51371c

GABA agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51374
Super-classes obo:CHEBI_35942c
Sub-classes obo:CHEBI_65259c

bosentanc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51450
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7008C17c)
obo:RO_0000087op some obo:CHEBI_51451c
obo:RO_0000087op some obo:CHEBI_35674c
Sub-classes obo:TXPO_0000032c

endothelin receptor antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_51451
Super-classes obo:CHEBI_49020c

Fosphenytoinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5165
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7038C17c)

biochemical rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52206
Super-classes obo:CHEBI_24432c
Sub-classes obo:CHEBI_68495c
obo:CHEBI_23924c
obo:CHEBI_83317c
obo:CHEBI_25212c
obo:CHEBI_35221c

biophysical rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52208
Super-classes obo:CHEBI_24432c
Sub-classes obo:CHEBI_38632c

aetiopathogenetic rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52209
Super-classes obo:CHEBI_24432c
Sub-classes obo:CHEBI_50902c
obo:CHEBI_50904c
obo:CHEBI_59132c
obo:CHEBI_50903c
obo:OBI_0000718c
obo:OBI_0000093c
obo:TXPO_0003995c
obo:TXPO_0000064c
obo:CHEBI_64909c
obo:CHEBI_50905c
obo:TXPO_0000038c
obo:TXPO_0003041c
obo:CHEBI_50908c

pharmacological rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52210
Super-classes obo:BFO_0000023c
obo:CHEBI_24432c
Sub-classes obo:CHEBI_48706c
obo:CHEBI_60832c
obo:CHEBI_74518c
obo:TXPO_0001426c
obo:CHEBI_35480c
obo:TXPO_0002262c
obo:CHEBI_33281c
obo:CHEBI_64911c
obo:CHEBI_35942c
obo:CHEBI_23888c
obo:CHEBI_48705c

ligandc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52214
Super-classes obo:CHEBI_51086c
Sub-classes obo:CHEBI_38161c

pharmaceuticalc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52217
Super-classes obo:BFO_0000023c
Sub-classes obo:CHEBI_23888c

mitogenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52290
Super-classes obo:CHEBI_24432c

EC 3.2.1.* (glycosidase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52424
Super-classes obo:CHEBI_76761c
Sub-classes obo:CHEBI_67239c
obo:CHEBI_50627c

EC 3.1.26.13 (retroviral ribonuclease H) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52629
Super-classes obo:CHEBI_76785c
obo:CHEBI_64947c
Sub-classes obo:CHEBI_53756c

bortezomibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52717
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_52726c
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_37670c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7147C17c)
obo:RO_0000087op some obo:CHEBI_35820c
Sub-classes obo:TXPO_0003021c

proteasome inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_52726
Super-classes obo:CHEBI_23888c

gemfibrozilc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5296
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35679c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7183C17c)
Sub-classes obo:TXPO_0004948c

topoisomerase IV inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_53559
Super-classes obo:CHEBI_70727c

HIV-1 reverse transcriptase inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_53756
Super-classes obo:CHEBI_64947c
obo:CHEBI_52629c

antispasmodic drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_53784
Super-classes obo:CHEBI_51371c

glyburidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5441
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0002697c

gastrointestinal drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_55324
Super-classes obo:CHEBI_23888c

anidulafunginc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_55346
Super-classes obo:CHEBI_50860c

malondialdehydec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_566274
Super-classes obo:TXPO_0004328c
Sub-classes obo:TXPO_0004502c
obo:TXPO_0004979c

atovaquonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_575568
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_77106c
obo:RO_0000087op some obo:CHEBI_35718c
obo:RO_0000087op some obo:CHEBI_38503c
obo:RO_0000087op some obo:CHEBI_77103c
obo:RO_0000087op some obo:CHEBI_38068c

ibuprofenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5855
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35475c
Sub-classes obo:TXPO_0004362c
obo:TXPO_0002035c

antigenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59132
Super-classes obo:CHEBI_52209c

EC 3.4.21.* (serine endopeptidase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5924
Super-classes obo:CHEBI_60258c
Sub-classes obo:CHEBI_76779c
obo:CHEBI_65232c

EC 1.14.13.132 (squalene monooxygenase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59285
Super-classes obo:CHEBI_76841c

Interferon alfa-2ac # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5937
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7326C17c)

Interferon beta-1bc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5938
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7347C17c)

DNA synthesis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59517
Super-classes obo:CHEBI_76932c
Restrictions obo:RO_0002599op some obo:GO_0071897c

Iproniazidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_5958
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7381C17c)

electrophilic reagentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59739
Super-classes obo:CHEBI_37527c

nucleophilic reagentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59740
Super-classes obo:CHEBI_22695c

progestinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59826
Super-classes obo:CHEBI_50745c

HIV fusion inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59886
Super-classes obo:CHEBI_64946c
obo:CHEBI_36044c

EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_59897
Super-classes obo:CHEBI_22587c
obo:CHEBI_38234c

micafunginc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_600520
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7447C17c)
obo:RO_0000087op some obo:CHEBI_35441c

phosphatidylinositol trisphosphatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_60169
Super-classes obo:CHEBI_28765c
Sub-classes obo:CHEBI_16618c

EC 3.4.* (hydrolases acting on peptide bond) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_60258
Super-classes obo:CHEBI_76759c
Sub-classes obo:CHEBI_5924c
obo:CHEBI_37670c

isoniazidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6030
Super-classes obo:CHEBI_50860c

isotretinoinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6067
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50176c
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_50905c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7506C17c)

itraconazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6076
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_140921c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7541C17c)
obo:RO_0000087op some obo:CHEBI_77748c
obo:RO_0000087op some obo:CHEBI_50183c

excitatory amino acid antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_60798
Super-classes obo:CHEBI_48706c

lysobisphosphatidic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_60815
Super-classes obo:CHEBI_32957c
Restrictions obo:RO_0000056op only obo:TXPO_0000010c
Sub-classes obo:TXPO_0001802c
obo:TXPO_0002296c

tubulin modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_60832
Super-classes obo:CHEBI_52210c
Sub-classes obo:CHEBI_61951c

nephrotoxinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_61015
Super-classes obo:CHEBI_64909c

EC 3.5.1.98 (histone deacetylase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_61115
Super-classes obo:CHEBI_76807c

fatty acid derivativec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_61697
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_23899c
obo:CHEBI_37554c

very long-chain fatty acyl-CoAc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_61910
Super-classes obo:CHEBI_37554c

microtubule-destabilising agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_61951
Super-classes obo:CHEBI_60832c
obo:CHEBI_64911c

EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_62434
Super-classes obo:CHEBI_76817c
obo:CHEBI_38637c

EC 1.2.3.1 (aldehyde oxidase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_62872
Super-classes obo:CHEBI_76853c

EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63090
Super-classes obo:CHEBI_76790c

reducing agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63247
Super-classes obo:CHEBI_51086c

oxidising agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63248
Super-classes obo:CHEBI_51086c

labetalolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6343
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35530c
obo:RO_0000087op some obo:CHEBI_35674c
obo:RO_0000087op some obo:CHEBI_37890c
obo:RO_0000087op some obo:CHEBI_66991c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7692C17c)

stavudinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63581
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_59897c
obo:RO_0000087op some obo:CHEBI_22587c
obo:RO_0000087op some obo:CHEBI_36044c
obo:RO_0000087op some obo:CHEBI_35221c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7733C17c)
Sub-classes obo:TXPO_0004388c

etravirinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63589
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_53756c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7764C17c)
obo:RO_0000087op some obo:CHEBI_22587c

levofloxacinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63598
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_53559c
obo:RO_0000087op some obo:CHEBI_59517c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7799C17c)
obo:RO_0000087op some obo:CHEBI_36047c

maravirocc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63608
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_59886c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7834C17c)
obo:RO_0000087op some obo:CHEBI_63673c
obo:RO_0000087op some obo:CHEBI_36044c

nevirapinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63613
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_53756c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7865C17c)
obo:RO_0000087op some obo:CHEBI_36044c

tipranavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63628
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7896C17c)
obo:RO_0000087op some obo:CHEBI_36044c
obo:RO_0000087op some obo:CHEBI_35660c

tizanidinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63629
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_51371c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7927C17c)
obo:RO_0000087op some obo:CHEBI_35569c

tolcaponec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63630
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_48406c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL7958C17c)
obo:RO_0000087op some obo:CHEBI_48407c

lamotriginec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6367
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_76779c
obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_35477c
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35469c
obo:RO_0000087op some obo:CHEBI_35703c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8017C17c)
obo:RO_0000087op some obo:CHEBI_38215c
obo:RO_0000087op some obo:CHEBI_35623c
obo:RO_0000087op some obo:CHEBI_60798c

chemokine receptor 5 antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63673
Super-classes obo:CHEBI_48706c

neuroprotective agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63726
Super-classes obo:CHEBI_50267c

riddelliinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63924
Description

A macrolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004503c

estrogen receptor agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_63951
Super-classes obo:CHEBI_48705c

protein kinase C agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64018
Super-classes obo:CHEBI_64106c

leflunomidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6402
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50908c
obo:RO_0000087op some obo:CHEBI_50266c
obo:RO_0000087op some obo:CHEBI_68543c
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_37153c
obo:RO_0000087op some obo:CHEBI_35705c
obo:RO_0000087op some obo:CHEBI_68542c
obo:RO_0000087op some obo:CHEBI_38637c
obo:RO_0000087op some obo:CHEBI_35442c
obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8120C17c)

protein kinase agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64106
Super-classes obo:CHEBI_48705c
Sub-classes obo:CHEBI_64018c

reaction intermediatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64297
Super-classes obo:CHEBI_51086c

posaconazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64355
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_36335c

glutamate transporter activatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64370
Super-classes obo:CHEBI_64371c

neurotransmitter transporter modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64371
Super-classes obo:CHEBI_38632c
obo:CHEBI_35942c
Sub-classes obo:CHEBI_64370c

phosphatidylcholinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64482
Super-classes obo:CHEBI_137209c

sphingomyelinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64583
Super-classes obo:CHEBI_35786c
Sub-classes obo:TXPO_0004147c

poisonc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64909
Super-classes obo:CHEBI_52209c
obo:CHEBI_24432c
Sub-classes obo:CHEBI_27026c
obo:TXPO_0000172c
obo:CHEBI_61015c

antimitoticc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64911
Super-classes obo:CHEBI_52210c
Sub-classes obo:CHEBI_61951c

antimycobacterial drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64912
Super-classes obo:CHEBI_36047c
Sub-classes obo:CHEBI_33231c
obo:CHEBI_35816c
obo:TXPO_0001996c

antiplasmodial drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64915
Super-classes obo:CHEBI_35442c
obo:CHEBI_35820c
Sub-classes obo:CHEBI_38068c

serine protease inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64926
Super-classes obo:CHEBI_37670c

anti-HIV agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64946
Super-classes obo:CHEBI_22587c
Sub-classes obo:CHEBI_59886c
obo:CHEBI_35660c
obo:CHEBI_64947c

anti-HIV-1 agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64947
Super-classes obo:CHEBI_64946c
Sub-classes obo:CHEBI_53756c
obo:CHEBI_52629c

lipoproteinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6495
Super-classes obo:CHEBI_33694c
Sub-classes obo:TXPO_0001339c
obo:CHEBI_132933c
obo:CHEBI_39027c
obo:CHEBI_39025c

EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_64964
Super-classes obo:CHEBI_76837c
obo:CHEBI_35856c

EC 3.1.1.3 (triacylglycerol lipase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_65001
Super-classes obo:CHEBI_76773c

anti-asthmatic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_65023
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_49167c

ximelagatranc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_65172
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_65232c
obo:RO_0000087op some obo:CHEBI_50249c
obo:RO_0000087op some obo:CHEBI_50266c
obo:RO_0000087op some obo:CHEBI_64926c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8304C17c)

second generation antipsychoticc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_65191
Super-classes obo:CHEBI_35476c
obo:TXPO_0003658c

vascular endothelial growth factor receptor antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_65207
Super-classes obo:CHEBI_48706c

EC 3.4.21.5 (thrombin) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_65232
Super-classes obo:CHEBI_5924c

GABA antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_65259
Super-classes obo:CHEBI_48706c
obo:CHEBI_51374c

antidyskinesia agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_66956
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_48407c

radiation protective agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_66987
Super-classes obo:CHEBI_50267c

sympatholytic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_66991
Super-classes obo:CHEBI_37962c

tocolytic agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_66993
Super-classes obo:CHEBI_50689c

insect sterilantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_67105
Super-classes obo:CHEBI_23092c
obo:CHEBI_24852c

ryanodine receptor agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_67114
Super-classes obo:CHEBI_38809c

mefenamic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6717
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35493c
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_78298c
obo:RO_0000087op some obo:CHEBI_35842c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8434C17c)
obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_35544c
obo:RO_0000087op some obo:CHEBI_35480c

AP-1 antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_67199
Super-classes obo:CHEBI_48706c

EC 3.2.1.20 (alpha-glucosidase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_67239
Super-classes obo:CHEBI_52424c

meloxicamc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6741
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0001982c

clofarabinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_681569
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35221c
obo:RO_0000087op some obo:CHEBI_35610c

apoptosis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_68494
Super-classes obo:TXPO_0000327c
Restrictions obo:RO_0002599op some obo:GO_0006915c

apoptosis inducerc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_68495
Super-classes obo:CHEBI_52206c
obo:TXPO_0000327c
Restrictions obo:RO_0002598op some obo:GO_0006915c

diethyl malatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_68508
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0001941c

glutathione depleting agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_68509
Super-classes obo:TXPO_0002037c
obo:TXPO_0000638c

EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_68542
Super-classes obo:CHEBI_76858c

pyrimidine synthesis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_68543
Super-classes obo:CHEBI_76932c

P2Y12 receptor antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_68563
Super-classes obo:CHEBI_91079c

mexiletinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_6916
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8566C17c)
obo:RO_0000087op some obo:CHEBI_38070c

topoisomerase inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_70727
Super-classes obo:CHEBI_76830c
Sub-classes obo:CHEBI_50750c
obo:CHEBI_53559c
obo:CHEBI_50276c

PPARalpha agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_70782
Super-classes obo:CHEBI_48705c

pazopanibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_71219
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_38637c
obo:RO_0000087op some obo:CHEBI_50926c
obo:RO_0000087op some obo:CHEBI_65207c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8620C17c)
obo:RO_0000087op some obo:CHEBI_35610c

EC 2.* (transferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_71300
Super-classes obo:CHEBI_23924c
Sub-classes obo:CHEBI_76668c
obo:CHEBI_76834c
obo:CHEBI_76661c
obo:CHEBI_76655c
obo:CHEBI_76662c

nitrofurantoinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_71415
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35441c
obo:RO_0000087op some obo:CHEBI_50908c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8663C17c)
obo:RO_0000087op some obo:CHEBI_36047c

EC 2.3.1.85 (fatty acid synthase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_71476
Super-classes obo:CHEBI_76878c

PPARgamma agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_71554
Super-classes obo:CHEBI_48705c

organic moleculec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_72695
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001122c
obo:CHEBI_17984c
obo:CHEBI_36976c
obo:CHEBI_33709c
obo:IMR_0001656c
obo:CHEBI_30879c
obo:IMR_0001693c
obo:CHEBI_33838c
obo:TXPO_0001144c

aryl hydrocarbon receptor agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_72768
Super-classes obo:CHEBI_48705c

lumiracoxibc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_73044
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_50629c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8723C17c)

EC 3.6.* (hydrolases acting on acid anhydrides) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_73216
Super-classes obo:CHEBI_76759c
Sub-classes obo:CHEBI_76895c

NF-kappaB inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_73240
Super-classes obo:TXPO_0003711c
obo:CHEBI_35222c

ketone bodyc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_73693
Super-classes obo:CHEBI_23899c

antifolatec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_73913
Super-classes obo:CHEBI_35221c
Sub-classes obo:CHEBI_50683c

EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_74213
Super-classes obo:CHEBI_76848c

epidermal growth factor receptor antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_74440
Super-classes obo:CHEBI_48706c
obo:CHEBI_37699c

anti-obesity agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_74518
Super-classes obo:CHEBI_52210c

nandrolonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7466
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_77746c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8804C17c)

nefazodonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7494
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50949c
obo:RO_0000087op some obo:CHEBI_35469c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8846C17c)
obo:RO_0000087op some obo:CHEBI_37890c
obo:RO_0000087op some obo:CHEBI_48279c
obo:RO_0000087op some obo:CHEBI_35480c

nelfinavirc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7496
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_35660c
Sub-classes obo:TXPO_0003023c

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinalc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_75142
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003020c

EC 5.* (isomerase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_75596
Super-classes obo:CHEBI_23924c
Sub-classes obo:CHEBI_76697c

nilutamidec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7573
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL8913C17c)
obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_35497c
Sub-classes obo:TXPO_0004338c

eukaryotic metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_75763
Super-classes obo:CHEBI_25212c
Sub-classes obo:CHEBI_75767c
obo:CHEBI_76946c

animal metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_75767
Super-classes obo:CHEBI_75763c
Sub-classes obo:CHEBI_83039c
obo:CHEBI_75768c

mammalian metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_75768
Super-classes obo:CHEBI_75767c
Sub-classes obo:CHEBI_75771c
obo:CHEBI_77746c

mouse metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_75771
Super-classes obo:CHEBI_75768c

prokaryotic metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_75787
Super-classes obo:CHEBI_25212c
Sub-classes obo:CHEBI_76969c

benoxaprofenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76114
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35493c
obo:RO_0000087op some obo:CHEBI_50748c
obo:RO_0000087op some obo:CHEBI_64018c
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_50908c
obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_64964c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9008C17c)
obo:RO_0000087op some obo:CHEBI_61015c

droxicamc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76133
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_50266c
obo:RO_0000087op some obo:CHEBI_50427c
obo:RO_0000087op some obo:CHEBI_50908c
obo:RO_0000087op some obo:CHEBI_35481c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9055C17c)
obo:RO_0000087op some obo:CHEBI_50630c

ibufenacc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76158
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9094C17c)
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_35544c
obo:RO_0000087op some obo:CHEBI_50908c

xenobiotic metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76206
Super-classes obo:CHEBI_25212c
Sub-classes obo:CHEBI_76967c

nortriptylinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7640
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9149C17c)
obo:RO_0000087op some obo:CHEBI_49103c
obo:RO_0000087op some obo:CHEBI_35480c
obo:RO_0000087op some obo:CHEBI_35640c
obo:RO_0000087op some obo:CHEBI_35469c
obo:RO_0000087op some obo:CHEBI_68495c
obo:RO_0000087op some obo:CHEBI_35610c

Chlorendic Acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76603
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004934c

EC 2.1.* (C1-transferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76655
Super-classes obo:CHEBI_71300c
Sub-classes obo:CHEBI_76871c

EC 2.3.* (acyltransferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76661
Super-classes obo:CHEBI_71300c
Sub-classes obo:CHEBI_76878c

EC 2.4.* (glycosyltransferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76662
Super-classes obo:CHEBI_71300c
Sub-classes obo:CHEBI_76790c

EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76663
Super-classes obo:CHEBI_76834c
Sub-classes obo:CHEBI_50502c
obo:CHEBI_76797c

EC 2.7.* (P-containing group transferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76668
Super-classes obo:CHEBI_71300c
Sub-classes obo:CHEBI_37699c
obo:CHEBI_76817c
obo:CHEBI_76812c
obo:CHEBI_76815c

EC 5.99.* (other isomerases) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76697
Super-classes obo:CHEBI_75596c
Sub-classes obo:CHEBI_76830c

EC 4.* (lyase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76710
Super-classes obo:CHEBI_23924c
Sub-classes obo:CHEBI_76712c

EC 4.2.* (C-O lyase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76712
Super-classes obo:CHEBI_76710c
Sub-classes obo:CHEBI_76907c

EC 1.* (oxidoreductase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76725
Super-classes obo:CHEBI_23924c
Sub-classes obo:CHEBI_76741c
obo:CHEBI_76726c
obo:CHEBI_76729c
obo:CHEBI_76737c
obo:CHEBI_76727c
obo:CHEBI_50183c
obo:CHEBI_76744c
obo:CHEBI_76740c
obo:CHEBI_76735c
obo:CHEBI_76731c
obo:CHEBI_76733c

EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76726
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76835c

EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76727
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76853c
obo:CHEBI_76852c

EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76729
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_77102c
obo:CHEBI_76858c

EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76731
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76863c

EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76733
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76866c

EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76735
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76869c

EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76737
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_77105c

EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76740
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76837c

EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76741
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76841c
obo:CHEBI_76838c
obo:CHEBI_76840c

EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76744
Super-classes obo:CHEBI_76725c
Sub-classes obo:CHEBI_76850c
obo:CHEBI_76848c

EC 3.* (hydrolase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76759
Description

Wikipedia:Hydrolase
Super-classes obo:CHEBI_23924c
Sub-classes obo:CHEBI_38462c
obo:CHEBI_73216c
obo:CHEBI_60258c
obo:TXPO_0000559c
obo:CHEBI_76764c
obo:CHEBI_76761c
obo:CHEBI_50469c
obo:CHEBI_76760c

EC 3.1.* (ester hydrolase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76760
Super-classes obo:CHEBI_76759c
Sub-classes obo:CHEBI_76785c
obo:CHEBI_76775c
obo:CHEBI_76773c

EC 3.2.* (glycosylase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76761
Super-classes obo:CHEBI_76759c
Sub-classes obo:CHEBI_52424c

EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76764
Super-classes obo:CHEBI_76759c
Sub-classes obo:CHEBI_76807c

EC 3.1.1.* (carboxylic ester hydrolase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76773
Super-classes obo:CHEBI_76760c
Sub-classes obo:CHEBI_37733c
obo:CHEBI_65001c
obo:CHEBI_78444c

EC 3.1.3.* (phosphoric monoester hydrolase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76775
Super-classes obo:CHEBI_76760c
Sub-classes obo:CHEBI_37153c

EC 3.4.21.26 (prolyl oligopeptidase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76779
Super-classes obo:CHEBI_5924c

EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76785
Super-classes obo:CHEBI_76760c
Sub-classes obo:CHEBI_52629c

EC 2.4.2.* (pentosyltransferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76790
Super-classes obo:CHEBI_76662c
Sub-classes obo:CHEBI_63090c

EC 2.5.1.18 (glutathione transferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76797
Super-classes obo:CHEBI_76663c

EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76807
Super-classes obo:CHEBI_76764c
Sub-classes obo:CHEBI_61115c

sphingomyelin phosphodiesterase inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76811
Super-classes obo:TXPO_0000559c

EC 2.7.11.* (protein-serine/threonine kinase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76812
Super-classes obo:CHEBI_37699c
obo:CHEBI_76668c
Sub-classes obo:CHEBI_50925c
obo:CHEBI_37700c

EC 2.7.7.* (nucleotidyltransferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76815
Super-classes obo:CHEBI_76668c
Sub-classes obo:CHEBI_38234c

EC 2.7.10.* (protein-tyrosine kinase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76817
Super-classes obo:CHEBI_37699c
obo:CHEBI_76668c
Sub-classes obo:CHEBI_62434c

EC 5.99.1.* (miscellaneous isomerase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76830
Super-classes obo:CHEBI_76697c
Sub-classes obo:CHEBI_70727c

EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76834
Super-classes obo:CHEBI_71300c
Sub-classes obo:CHEBI_76663c

EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76835
Super-classes obo:CHEBI_76726c
Sub-classes obo:CHEBI_48550c

EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76837
Super-classes obo:CHEBI_76740c
Sub-classes obo:CHEBI_35856c
obo:CHEBI_64964c

EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76838
Super-classes obo:CHEBI_76741c
Sub-classes obo:CHEBI_76898c
obo:CHEBI_50790c

EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76840
Super-classes obo:CHEBI_76741c
Sub-classes obo:CHEBI_35544c

EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76841
Super-classes obo:CHEBI_76741c
Sub-classes obo:CHEBI_59285c

EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76848
Super-classes obo:CHEBI_76744c
Sub-classes obo:CHEBI_74213c

EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76850
Super-classes obo:CHEBI_76744c
Sub-classes obo:CHEBI_35634c

EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76852
Super-classes obo:CHEBI_76727c
Sub-classes obo:CHEBI_35487c

EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76853
Super-classes obo:CHEBI_76727c
Sub-classes obo:CHEBI_62872c

EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76858
Super-classes obo:CHEBI_76729c
Sub-classes obo:CHEBI_68542c

EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76863
Super-classes obo:CHEBI_76731c
Sub-classes obo:CHEBI_50683c

EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76866
Super-classes obo:CHEBI_76733c
Sub-classes obo:CHEBI_38503c

EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76869
Super-classes obo:CHEBI_76735c
Sub-classes obo:CHEBI_77402c

EC 2.1.1.* (methyltransferases) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76871
Super-classes obo:CHEBI_76655c
Sub-classes obo:CHEBI_48406c

EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76878
Super-classes obo:CHEBI_76661c
Sub-classes obo:CHEBI_71476c

EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76895
Super-classes obo:CHEBI_73216c
Sub-classes obo:CHEBI_77748c

EC 1.14.14.1 (unspecific monooxygenase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76898
Super-classes obo:CHEBI_76838c
Sub-classes obo:CHEBI_50183c

EC 4.2.1.* (hydro-lyases) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76907
Super-classes obo:CHEBI_76712c
Sub-classes obo:CHEBI_23018c

pathway inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76932
Super-classes obo:CHEBI_23924c
obo:TXPO_0003720c
Sub-classes obo:CHEBI_68543c
obo:CHEBI_38496c
obo:CHEBI_59517c
obo:CHEBI_140921c
obo:CHEBI_48001c
obo:TXPO_0003721c
obo:TXPO_0003911c

fungal metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76946
Super-classes obo:CHEBI_75763c
Sub-classes obo:CHEBI_76964c

Penicillium metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76964
Super-classes obo:CHEBI_76946c

human xenobiotic metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76967
Super-classes obo:CHEBI_76206c
obo:CHEBI_77746c
Sub-classes obo:CHEBI_49103c

bacterial metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76969
Super-classes obo:CHEBI_75787c
Sub-classes obo:CHEBI_76971c

Escherichia coli metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76971
Super-classes obo:CHEBI_76969c

aryl hydrocarbon receptor antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_76998
Super-classes obo:CHEBI_48706c

EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77102
Super-classes obo:CHEBI_76729c
Sub-classes obo:CHEBI_77103c

EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77103
Super-classes obo:CHEBI_77102c

EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77105
Super-classes obo:CHEBI_76737c
Sub-classes obo:CHEBI_77106c

EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77106
Super-classes obo:CHEBI_77105c

IkappaB kinase inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77113
Super-classes obo:CHEBI_23924c

androstane receptor agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77326
Super-classes obo:CHEBI_48705c

EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77402
Super-classes obo:CHEBI_76869c

p53 activatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77731
Super-classes obo:TXPO_0003714c

human metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77746
Super-classes obo:CHEBI_75768c
Sub-classes obo:CHEBI_76967c

EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_77748
Super-classes obo:CHEBI_76895c

oxandrolonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7820
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_36413c
obo:RO_0000087op some obo:CHEBI_50113c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9756C17c)

environmental contaminantc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_78298
Super-classes obo:CHEBI_51086c

EC 3.1.1.1 (carboxylesterase) inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_78444
Super-classes obo:CHEBI_76773c

oxymetholonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7864
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50113c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9803C17c)
obo:RO_0000087op some obo:CHEBI_36413c

17β-estradiol 17-glucosiduronic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_791
Super-classes obo:CHEBI_35341c
Sub-classes obo:TXPO_0003115c

pemolinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_7953
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9838C17c)
obo:RO_0000087op some obo:CHEBI_35337c

phenobarbitalc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_8069
Super-classes obo:CHEBI_22693c
Restrictions obo:RO_0000087op some obo:CHEBI_35623c
Sub-classes obo:TXPO_0001524c
obo:TXPO_0004448c

phenytoinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_8107
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_38633c
obo:RO_0000087op some obo:CHEBI_88188c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9890C17c)
obo:RO_0000087op some obo:CHEBI_35623c
obo:RO_0000087op some obo:CHEBI_50905c

crustacean metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_83039
Super-classes obo:CHEBI_75767c
Sub-classes obo:CHEBI_83057c

Daphnia magna metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_83056
Super-classes obo:CHEBI_83057c

Daphnia metabolitec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_83057
Super-classes obo:CHEBI_83039c
Sub-classes obo:CHEBI_83056c

sterol biosynthesis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_83317
Super-classes obo:CHEBI_52206c
obo:CHEBI_35222c

hepatic steatosis inducing agentc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_83612
Super-classes obo:CHEBI_50908c

eltrombopagc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_85010
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_85012c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL9960C17c)

thrombopoietin receptor agonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_85012
Super-classes obo:CHEBI_48705c

antifungal drugc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_86327
Super-classes obo:CHEBI_35718c

antifungal agrochemicalc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_86328
Super-classes obo:CHEBI_25944c

drug allergenc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_88188
Super-classes obo:CHEBI_50904c
obo:CHEBI_23888c

autophagy inhibitorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_88230
Super-classes obo:TXPO_0002629c
Restrictions obo:RO_0002599op some obo:GO_0006914c

Riluzolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_8863
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10025C17c)

lysophosphatidylglycerolc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_90454
Super-classes obo:CHEBI_24360c

receptor modulatorc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_90710
Super-classes obo:CHEBI_23888c
Sub-classes obo:CHEBI_51061c

purinergic receptor P2 antagonistc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_91079
Super-classes obo:CHEBI_48706c
Sub-classes obo:CHEBI_68563c

sulfasalazinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9334
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10091C17c)
obo:RO_0000087op some obo:CHEBI_35441c
obo:RO_0000087op some obo:CHEBI_35475c
obo:RO_0000087op some obo:CHEBI_76797c
obo:RO_0000087op some obo:CHEBI_55324c
obo:RO_0000087op some obo:CHEBI_88188c

sulfathiazolec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9337
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_50502c
obo:RO_0000087op some obo:CHEBI_88188c
obo:RO_0000087op some obo:CHEBI_35703c
obo:RO_0000087op some obo:CHEBI_35441c
obo:RO_0000087op some obo:CHEBI_78298c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10134C17c)

sulindacc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9352
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:RO_0000087op some obo:CHEBI_35544c
obo:RO_0000087op some obo:CHEBI_50266c
obo:RO_0000087op some obo:CHEBI_35493c
obo:RO_0000087op some obo:CHEBI_66993c
obo:RO_0000087op some obo:CHEBI_35480c
obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10194C17c)
obo:RO_0000087op some obo:CHEBI_35481c
obo:RO_0000087op some obo:CHEBI_35475c
Sub-classes obo:TXPO_0003118c

terbinafinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9448
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_83317c
obo:RO_0000087op some obo:CHEBI_59285c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10229C17c)
obo:RO_0000087op some obo:CHEBI_50183c

orlistatc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_94686
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10268C17c)
obo:RO_0000087op some obo:CHEBI_71476c
obo:RO_0000087op some obo:CHEBI_74518c
obo:RO_0000087op some obo:CHEBI_76969c
obo:RO_0000087op some obo:CHEBI_65001c

thapsigarginc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9516
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_38215c
Sub-classes obo:TXPO_0003015c

ticlopidinec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9588
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_48676c
obo:RO_0000087op some obo:CHEBI_68563c
obo:RO_0000087op some obo:CHEBI_50427c
obo:RO_0000087op some obo:CHEBI_50248c
obo:RO_0000087op some obo:CHEBI_50249c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10325C17c)

Trimethadionec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9727
Super-classes obo:CHEBI_50860c

troglitazonec # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9753
Description

Wikipedia:Troglitazone
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35610c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10388C17c)
obo:RO_0000087op some obo:CHEBI_22586c
obo:RO_0000087op some obo:CHEBI_35623c
obo:RO_0000087op some obo:CHEBI_50249c
obo:RO_0000087op some obo:CHEBI_35620c
obo:RO_0000087op some obo:CHEBI_50427c
obo:RO_0000087op some obo:CHEBI_35526c
Sub-classes obo:TXPO_0000931c
obo:TXPO_0004337c

trovafloxacinc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9763
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_59517c
obo:RO_0000087op some obo:CHEBI_33281c
obo:RO_0000087op some obo:CHEBI_36047c
obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL10431C17c)
obo:RO_0000087op some obo:CHEBI_50908c
obo:RO_0000087op some obo:CHEBI_53559c

ursodeoxycholic acidc # Classes

URI http://purl.obolibrary.org/obo/CHEBI_9907
Super-classes obo:TXPO_0000509c

cell line cellc # Classes

URI http://purl.obolibrary.org/obo/CLO_0000001
Super-classes obo:OBI_0001866c

cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000000
Description

The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
Super-classes obo:GO_0005575c
Sub-classes obo:CL_0000891c
obo:CL_0000988c
obo:CL_0000578c
obo:CL_0000151c
obo:CL_0002320c
obo:CL_0000056c
obo:CL_0000066c
obo:CL_0000234c

primary cultured cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000001
Super-classes obo:CL_0000010c

cultured cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000010
Super-classes obo:CL_0000578c
Sub-classes obo:CL_0000001c
obo:OBI_0001866c

myoblastc # Classes

URI http://purl.obolibrary.org/obo/CL_0000056
Super-classes obo:CL_0000000c

fibroblastc # Classes

URI http://purl.obolibrary.org/obo/CL_0000057
Super-classes obo:CL_0002320c
Sub-classes obo:CL_0000632c

epithelial cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000066
Super-classes obo:CL_0000000c
Sub-classes obo:CL_0000182c

T cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000084
Super-classes obo:CL_0000542c
Sub-classes obo:CL_0000789c

Kupffer cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000091
Super-classes obo:CL_0000864c

granulocytec # Classes

URI http://purl.obolibrary.org/obo/CL_0000094
Super-classes obo:CL_0000988c
Sub-classes obo:CL_0000771c
obo:CL_0000767c
obo:CL_0000775c

mast cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000097
Super-classes obo:CL_0000738c

fat cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000136
Super-classes obo:CL_0002320c
Sub-classes obo:CL_0000449c
obo:CL_0000448c

secretory cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000151
Super-classes obo:CL_0000000c
Sub-classes obo:CL_0000233c
obo:CL_0000168c

insulin secreting cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000168
Super-classes obo:CL_0000151c
Sub-classes obo:CL_0000169c

type B pancreatic cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000169
Super-classes obo:CL_0000168c

hepatocytec # Classes

URI http://purl.obolibrary.org/obo/CL_0000182
Super-classes obo:CL_0000066c

erythrocytec # Classes

URI http://purl.obolibrary.org/obo/CL_0000232
Super-classes obo:CL_0000988c

plateletc # Classes

URI http://purl.obolibrary.org/obo/CL_0000233
Description

Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
Super-classes obo:CL_0000151c

phagocytec # Classes

URI http://purl.obolibrary.org/obo/CL_0000234
Super-classes obo:CL_0000000c
Sub-classes obo:CL_0000235c

macrophagec # Classes

URI http://purl.obolibrary.org/obo/CL_0000235
Description

Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
Super-classes obo:CL_0000234c
Sub-classes obo:NCIT_C116387c
obo:CL_0000863c
obo:CL_0000864c

B cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000236
Super-classes obo:CL_0000542c
Sub-classes obo:CL_0000786c

white fat cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000448
Super-classes obo:CL_0000136c

brown fat cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000449
Super-classes obo:CL_0000136c

dendritic cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000451
Super-classes obo:CL_0000738c

lymphocytec # Classes

URI http://purl.obolibrary.org/obo/CL_0000542
Super-classes obo:CL_0000842c
Sub-classes obo:CL_0000236c
obo:TXPO_0001526c
obo:CL_0000084c

monocytec # Classes

URI http://purl.obolibrary.org/obo/CL_0000576
Super-classes obo:CL_0000842c

experimentally modified cell in vitroc # Classes

URI http://purl.obolibrary.org/obo/CL_0000578
Super-classes obo:CL_0000000c
Sub-classes obo:CL_0000010c

hepatic stellate cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000632
Super-classes obo:CL_0000057c

leukocytec # Classes

URI http://purl.obolibrary.org/obo/CL_0000738
Super-classes obo:CL_0000988c
Sub-classes obo:CL_0000451c
obo:CL_0000097c
obo:CL_0000842c

basophilc # Classes

URI http://purl.obolibrary.org/obo/CL_0000767
Super-classes obo:CL_0000094c

eosinophilc # Classes

URI http://purl.obolibrary.org/obo/CL_0000771
Super-classes obo:CL_0000094c

neutrophilc # Classes

URI http://purl.obolibrary.org/obo/CL_0000775
Super-classes obo:CL_0000094c

plasma cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000786
Super-classes obo:CL_0000236c

alpha-beta T cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000789
Super-classes obo:CL_0000084c

mononuclear cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000842
Super-classes obo:CL_0000738c
Sub-classes obo:CL_0000576c
obo:CL_0000542c

inflammatory macrophagec # Classes

URI http://purl.obolibrary.org/obo/CL_0000863
Description

Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).
Super-classes obo:CL_0000235c

tissue-resident macrophagec # Classes

URI http://purl.obolibrary.org/obo/CL_0000864
Super-classes obo:CL_0000235c
Sub-classes obo:CL_0000091c

foam cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000891
Super-classes obo:CL_0000000c

hematopoietic cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0000988
Super-classes obo:CL_0000000c
Sub-classes obo:CL_0000738c
obo:CL_0000232c
obo:CL_0000094c

connective tissue cellc # Classes

URI http://purl.obolibrary.org/obo/CL_0002320
Super-classes obo:CL_0000000c
Sub-classes obo:CL_0000057c
obo:CL_0000136c

Niemann-Pick disease type Ac # Classes

URI http://purl.obolibrary.org/obo/DOID_0070111
Super-classes obo:DOID_14504c

Niemann-Pick disease type Bc # Classes

URI http://purl.obolibrary.org/obo/DOID_0070112
Super-classes obo:DOID_14504c

Niemann-Pick disease type C1c # Classes

URI http://purl.obolibrary.org/obo/DOID_0070113
Super-classes obo:DOID_14504c

Niemann-Pick disease type C2c # Classes

URI http://purl.obolibrary.org/obo/DOID_0070114
Super-classes obo:DOID_14504c

Niemann-Pick diseasec # Classes

URI http://purl.obolibrary.org/obo/DOID_14504
Super-classes obo:DOID_4c
Sub-classes obo:DOID_0070111c
obo:DOID_0070113c
obo:DOID_0070112c
obo:DOID_0070114c

diseasec # Classes

URI http://purl.obolibrary.org/obo/DOID_4
Super-classes obo:BFO_0000016c
Sub-classes obo:DOID_14504c
obo:DOID_9351c
In range of obo:TXPO_0003585op

diabetes mellitusc # Classes

URI http://purl.obolibrary.org/obo/DOID_9351
Super-classes obo:DOID_4c
Sub-classes obo:DOID_9744c
obo:DOID_9352c

type 2 diabetes mellitusc # Classes

URI http://purl.obolibrary.org/obo/DOID_9352
Super-classes obo:DOID_9351c

type 1 diabetes mellitusc # Classes

URI http://purl.obolibrary.org/obo/DOID_9744
Super-classes obo:DOID_9351c

substance with antioxidant rolec # Classes

URI http://purl.obolibrary.org/obo/GOCHE_22586
Super-classes obo:GOCHE_50906c
Restrictions obo:RO_0000087op some obo:CHEBI_22586c

substance with rolec # Classes

URI http://purl.obolibrary.org/obo/GOCHE_50906
Description

In YAMATO ontology theory, an entity (continuant) playing a role in a specific context is called a role holder.
Super-classes obo:BFO_0000030c
Restrictions obo:RO_0000087op some obo:BFO_0000023c
Sub-classes obo:TXPO_0002106c
obo:TXPO_0000257c
obo:TXPO_0000260c
obo:GOCHE_22586c
obo:TXPO_0003353c
obo:GOCHE_52214c

substance with ligand rolec # Classes

URI http://purl.obolibrary.org/obo/GOCHE_52214
Description

This entity is inferred from Description Logic.
Super-classes obo:GOCHE_50906c

fatty-acyl-CoA bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0000062
Super-classes obo:GO_1901567c
Restrictions obo:RO_0002233op some obo:CHEBI_37554c
Sub-classes obo:GO_0036042c

cytoplasmic chromosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0000229
Super-classes obo:GO_0005694c
Restrictions obo:BFO_0000050op some obo:GO_0005737c

mitochondrial fissionc # Classes

URI http://purl.obolibrary.org/obo/GO_0000266
Super-classes obo:TXPO_0002576c
Restrictions obo:RO_0002233op some obo:GO_0005739c
Sub-classes obo:TXPO_0004261c
obo:TXPO_0004311c

M phasec # Classes

URI http://purl.obolibrary.org/obo/GO_0000279
Super-classes obo:GO_0022403c

autophagy of mitochondrionc # Classes

URI http://purl.obolibrary.org/obo/GO_0000422
Super-classes obo:GO_0006914c
Restrictions obo:RO_0002233op some obo:GO_0005739c
Sub-classes obo:GO_0000423c

mitohagyc # Classes

URI http://purl.obolibrary.org/obo/GO_0000423
Super-classes obo:GO_0000422c
Restrictions obo:RO_0002233op some obo:GO_0005739c
Sub-classes obo:TXPO_0002010c

pexophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_0000425
Super-classes obo:GO_0030242c
Restrictions obo:RO_0002233op some obo:GO_0005777c
Sub-classes obo:TXPO_0003219c

response to hypoxiac # Classes

URI http://purl.obolibrary.org/obo/GO_0001666
Super-classes obo:GO_0006950c
Sub-classes obo:TXPO_0004837c

long-chain fatty acid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0001676
Super-classes obo:GO_0006631c
Sub-classes obo:TXPO_0003884c

formation of cytoplasmic translation initiation complexc # Classes

URI http://purl.obolibrary.org/obo/GO_0001732
Super-classes obo:GO_0006461c

cell activationc # Classes

URI http://purl.obolibrary.org/obo/GO_0001775
Super-classes obo:TXPO_0000401c
Restrictions obo:RO_0002234op some (obo:CL_0000000c and ub744bL10991C17c)
Sub-classes obo:GO_0045321c
obo:GO_0035733c

natural killer cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_0001787
Super-classes obo:GO_0046651c

cytokine productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0001816
Description

Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
Super-classes obo:TXPO_0000382c
Restrictions obo:BFO_0000051op some obo:GO_0042089c
Sub-classes obo:GO_0032905c
obo:GO_0032606c
obo:GO_0071706c
obo:GO_0071604c
obo:TXPO_0004304c
obo:GO_0002367c
obo:GO_0032623c
obo:GO_0032602c
obo:GO_0032611c
obo:GO_0032609c
obo:GO_0002534c
obo:GO_0032612c

release of cytochrome c from mitochondriac # Classes

URI http://purl.obolibrary.org/obo/GO_0001836
Super-classes obo:TXPO_0002588c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0003105c
obo:TXPO_0002403c
obo:TXPO_0004263c

epithelial to mesenchymal transitionc # Classes

URI http://purl.obolibrary.org/obo/GO_0001837
Super-classes obo:GO_0030154c
Sub-classes obo:TXPO_0004422c

phagolysosome assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0001845
Super-classes obo:GO_0071840c
Restrictions obo:BFO_0000050op some obo:GO_0006909c

NK T cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0001865
Description

Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Super-classes obo:GO_0030217c

TLR signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0002224
Super-classes obo:TXPO_0000609c
Sub-classes obo:GO_0034142c
obo:GO_0034162c

natural killer cell mediated immunityc # Classes

URI http://purl.obolibrary.org/obo/GO_0002228
Super-classes obo:GO_0045087c
Restrictions obo:RO_0000057op some obo:TXPO_0001526c

adaptive immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0002250
Super-classes obo:GO_0006955c
Sub-classes obo:GO_0035397c

cytokine production involved in immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0002367
Super-classes obo:GO_0001816c

hepatic immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0002384
Super-classes obo:GO_0006955c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c

immune response to tumor cellc # Classes

URI http://purl.obolibrary.org/obo/GO_0002418
Super-classes obo:GO_0006955c

leukocyte differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0002521
Super-classes obo:GO_0030154c
Sub-classes obo:GO_0030225c
obo:GO_0030098c

cytokine production involved in inflammatory responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0002534
Super-classes obo:GO_0001816c
Sub-classes obo:TXPO_0004269c

DNA bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0003677
Super-classes obo:GO_0005488c

ketone biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_00042181
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_73693c
Sub-classes obo:TXPO_0004065c

binding (with molecule)c # Classes

URI http://purl.obolibrary.org/obo/GO_0005488
Super-classes obo:TXPO_0000469c
Sub-classes obo:GO_1901567c
obo:TXPO_0003343c
obo:GO_0005515c
obo:TXPO_0001398c
obo:GO_0008289c
obo:GO_0003677c
obo:TXPO_0002066c
obo:TXPO_0004500c
obo:TXPO_0002118c

fatty acid bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0005504
Super-classes obo:GO_0008289c
Sub-classes obo:GO_0036041c

protein bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0005515
Super-classes obo:GO_0005488c
Sub-classes obo:TXPO_0001693c
obo:TXPO_0003117c
obo:TXPO_0002786c

phospholipid bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0005543
Super-classes obo:GO_0008289c
Sub-classes obo:GO_0070300c
obo:TXPO_0003640c
obo:GO_1901611c
obo:GO_0031210c
obo:GO_0008429c

cellular_componentc # Classes

URI http://purl.obolibrary.org/obo/GO_0005575
Super-classes obo:UBERON_0001062c
obo:GO_0005575c
Sub-classes obo:GO_0043226c
obo:GO_0044464c
obo:TXPO_0000895c
obo:CL_0000000c
obo:GO_0005575c
obo:TXPO_0000332c

extracellular regionc # Classes

URI http://purl.obolibrary.org/obo/GO_0005576
Description

Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
Super-classes obo:GO_0044464c

extracellular spacec # Classes

URI http://purl.obolibrary.org/obo/GO_0005615
Description

Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
Super-classes obo:GO_0044464c
Restrictions obo:BFO_0000050op some obo:GO_0005576c

intracellularc # Classes

URI http://purl.obolibrary.org/obo/GO_0005622
Super-classes obo:GO_0044464c

nucleusc # Classes

URI http://purl.obolibrary.org/obo/GO_0005634
Super-classes obo:GO_0043227c
Restrictions obo:BFO_0000051op some obo:GO_0031965c
obo:BFO_0000050op some obo:GO_0005622c

chromosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005694
Description

Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
Super-classes obo:GO_0043226c
Restrictions obo:BFO_0000050op some obo:GO_0005622c
Sub-classes obo:GO_0000229c
obo:TXPO_0002543c

cytoplasmc # Classes

URI http://purl.obolibrary.org/obo/GO_0005737
Super-classes obo:TXPO_0000065c
Restrictions obo:BFO_0000050op some obo:GO_0005622c

mitochondrionc # Classes

URI http://purl.obolibrary.org/obo/GO_0005739
Super-classes obo:GO_0043227c
Restrictions obo:BFO_0000051op some obo:GO_0031966c

mitochondrial outer membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0005741
Super-classes obo:GO_0031966c

mitochondrial inner membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0005743
Super-classes obo:GO_0031966c

mitochondrial respiratory chain complex Ic # Classes

URI http://purl.obolibrary.org/obo/GO_0005747
Super-classes obo:GO_0098800c
Restrictions obo:RO_0002180op some obo:TXPO_0004329c

mitochondrial respiratory chain complex IVc # Classes

URI http://purl.obolibrary.org/obo/GO_0005751
Super-classes obo:GO_0098800c

lysosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005764
Description

Another function of the ER in eucaryotic cells is to sequester Ca2+ from the cytosol. Cell
Super-classes obo:GO_0005773c
Restrictions obo:BFO_0000051op some obo:GO_0005765c
obo:RO_0000086op some obo:PATO_0001429c

lysosomal membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0005765
Super-classes obo:GO_0031090c
Restrictions obo:BFO_0000050op some obo:GO_0005764c

endosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005768
Super-classes obo:GO_0031982c
Sub-classes obo:GO_0055037c
obo:GO_0005769c
obo:GO_0005770c

early endosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005769
Super-classes obo:GO_0005768c

late endosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005770
Super-classes obo:GO_0005768c

vacuolec # Classes

URI http://purl.obolibrary.org/obo/GO_0005773
Super-classes obo:GO_0043227c
Restrictions obo:BFO_0000050op some obo:GO_0005737c
Sub-classes obo:GO_0005776c
obo:GO_0005764c

autophagosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005776
Super-classes obo:GO_0005773c

peroxisomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005777
Super-classes obo:GO_0042579c
Restrictions obo:BFO_0000050op some obo:GO_0005737c

endoplasmic reticulumc # Classes

URI http://purl.obolibrary.org/obo/GO_0005783
Super-classes obo:GO_0043227c
Restrictions obo:TXPO_0001896op some obo:GO_0016042c
obo:TXPO_0001896op some obo:GO_0008610c
obo:BFO_0000051op some obo:GO_0005788c
obo:TXPO_0001896op some obo:TXPO_0000820c
obo:TXPO_0001896op some obo:GO_0051208c
obo:BFO_0000051op some obo:GO_0005789c
obo:BFO_0000050op some obo:GO_0005622c
obo:TXPO_0001896op some obo:TXPO_0000173c
Sub-classes obo:GO_0005791c
obo:GO_0005790c

endoplasmic reticulum lumenc # Classes

URI http://purl.obolibrary.org/obo/GO_0005788
Super-classes obo:GO_0043233c

endoplasmic reticulum membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0005789
Super-classes obo:GO_0031090c

smooth endoplasmic reticulumc # Classes

URI http://purl.obolibrary.org/obo/GO_0005790
Description

The hepatocyte is a cell with an abundant smooth ER.
Super-classes obo:GO_0005783c
Restrictions obo:BFO_0000067op some obo:TXPO_0000173c
obo:BFO_0000067op some obo:GO_0042158c

rough endoplasmic reticulumc # Classes

URI http://purl.obolibrary.org/obo/GO_0005791
Super-classes obo:GO_0005783c

golgi apparatusc # Classes

URI http://purl.obolibrary.org/obo/GO_0005794
Description

Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
Super-classes obo:GO_0043227c
Restrictions obo:BFO_0000050op some obo:GO_0005737c
obo:BFO_0000051op some obo:GO_0005796c

Golgi lumenc # Classes

URI http://purl.obolibrary.org/obo/GO_0005796
Super-classes obo:GO_0043233c

microtubule organizing centerc # Classes

URI http://purl.obolibrary.org/obo/GO_0005815
Super-classes obo:GO_0044464c
Restrictions obo:BFO_0000050op some obo:GO_0005856c

cytosolc # Classes

URI http://purl.obolibrary.org/obo/GO_0005829
Super-classes obo:TXPO_0000065c
Restrictions obo:BFO_0000050op some obo:GO_0005737c

ribosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0005840
Super-classes obo:GO_0043226c
Restrictions obo:BFO_0000050op some obo:GO_0005737c

cytoskeletonc # Classes

URI http://purl.obolibrary.org/obo/GO_0005856
Super-classes obo:GO_0043226c
Restrictions obo:BFO_0000050op some obo:GO_0005622c

plasma membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0005886
Super-classes obo:TXPO_0000895c
Restrictions obo:BFO_0000050op some obo:CL_0000000c

carbohydrate metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0005975
Super-classes obo:GO_0008152c
Restrictions obo:BFO_0000051op some obo:GO_0016052c
obo:BFO_0000051op some obo:GO_0016051c
Sub-classes obo:GO_0005977c

glycogen metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0005977
Super-classes obo:GO_0005975c
Restrictions obo:BFO_0000051op some obo:GO_0005978c
obo:BFO_0000051op some obo:GO_0005980c

glycogen biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0005978
Super-classes obo:GO_0016051c
Restrictions obo:RO_0002234op some obo:CHEBI_28087c

glycogen catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0005980
Super-classes obo:GO_0016052c
Restrictions obo:RO_0002233op some obo:CHEBI_28087c
Sub-classes obo:TXPO_0000958c

alcohol metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006066
Super-classes obo:GO_0008152c
Sub-classes obo:TXPO_0000900c

generation of precursor metabolites and energyc # Classes

URI http://purl.obolibrary.org/obo/GO_0006091
Super-classes obo:GO_0008152c

gluconeogenesisc # Classes

URI http://purl.obolibrary.org/obo/GO_0006094
Super-classes obo:GO_0016051c
Restrictions obo:RO_0002234op some obo:CHEBI_17234c

glycolytic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006096
Super-classes obo:GO_0016052c
Sub-classes obo:TXPO_0000153c
obo:TXPO_0004634c

tricarboxylic acid cyclec # Classes

URI http://purl.obolibrary.org/obo/GO_0006099
Super-classes obo:GO_0008152c
Restrictions obo:BFO_0000066op some obo:GO_0005739c

regulation of carbohydrate metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006109
Super-classes obo:GO_0019222c
Restrictions obo:RO_0002211op some obo:GO_0005975c
Sub-classes obo:TXPO_0000149c

oxidative phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006119
Super-classes obo:GO_0016310c
Sub-classes obo:TXPO_0001745c

mitochondrial electron transport, NADH to ubiquinonec # Classes

URI http://purl.obolibrary.org/obo/GO_0006120
Super-classes obo:GO_0022904c

mitochondrial electron transport, succinate to ubiquinonec # Classes

URI http://purl.obolibrary.org/obo/GO_0006121
Super-classes obo:GO_0022904c

mitochondrial electron transport, ubiquinol to cytochrome cc # Classes

URI http://purl.obolibrary.org/obo/GO_0006122
Super-classes obo:GO_0022904c

DNA replicationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006260
Super-classes obo:TXPO_0000093c
Restrictions obo:TXPO_0000531op some obo:TXPO_0000304c
Sub-classes obo:TXPO_0004517c

DNA repairc # Classes

URI http://purl.obolibrary.org/obo/GO_0006281
Super-classes obo:TXPO_0000535c
Sub-classes obo:TXPO_0002137c

DNA alkylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006305
Super-classes obo:GO_0008152c
Sub-classes obo:TXPO_0004497c

DNA methylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006306
Super-classes obo:GO_0032259c
Sub-classes obo:TXPO_0004788c
obo:TXPO_0004688c
obo:TXPO_0004775c

DNA catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006308
Super-classes obo:GO_0009056c
Sub-classes obo:GO_0032043c
obo:GO_0006309c

apoptotic DNA fragmentationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006309
Description

DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
Super-classes obo:GO_0006308c
Sub-classes obo:TXPO_0002388c

chromatin remodelingc # Classes

URI http://purl.obolibrary.org/obo/GO_0006338
Super-classes obo:TXPO_0002566c

transcription, DNA-templatedc # Classes

URI http://purl.obolibrary.org/obo/GO_0006351
Super-classes obo:GO_0010467c

regulation of transcription, DNA-templatedc # Classes

URI http://purl.obolibrary.org/obo/GO_0006355
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0006351c
Sub-classes obo:GO_0045892c

mRNA cleavagec # Classes

URI http://purl.obolibrary.org/obo/GO_0006379
Super-classes obo:TXPO_0000333c

mRNA catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006402
Super-classes obo:GO_0009056c

translationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006412
Super-classes obo:GO_0010467c

regulation of translationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006417
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0006412c
Sub-classes obo:GO_0009386c
obo:TXPO_0002874c

protein foldingc # Classes

URI http://purl.obolibrary.org/obo/GO_0006457
Description

Due to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and associate with proteins in their non-native state and facilitate their folding by stabilizing the conformation of productive folding intermediates. Chaperones that take part broadly in de novo protein folding, such as the Hsp70s and the chaperonins, facilitate the folding process through cycles of substrate binding and release regulated by their ATPase activity (see Young et al., 2004; Spiess et al., 2004; Bigotti and Clarke, 2008).
Super-classes obo:TXPO_0002565c
Sub-classes obo:GO_0042026c

protein complex assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0006461
Super-classes obo:GO_0065003c
Sub-classes obo:TXPO_0001212c
obo:GO_0097314c
obo:TXPO_0003114c
obo:GO_0051258c
obo:GO_0001732c

protein acetylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006473
Super-classes obo:GO_0043543c

protein deacetylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006476
Super-classes obo:GO_0035601c

protein glycosylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006486
Super-classes obo:GO_0070085c

protein lipidationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006497
Super-classes obo:GO_0036211c
Sub-classes obo:GO_0018377c
obo:GO_0045234c

proteolysisc # Classes

URI http://purl.obolibrary.org/obo/GO_0006508
Description

This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.
Super-classes obo:TXPO_0000333c
Restrictions obo:RO_0002233op some obo:CHEBI_36080c
Sub-classes obo:GO_0016485c

protein deglycosylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006517
Super-classes obo:GO_0036211c

cellular amino acid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006520
Super-classes obo:GO_0044281c
Restrictions obo:RO_0000057op some obo:CHEBI_33709c
obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:HINO_0016364c

methionine metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006555
Super-classes obo:GO_0008152c
Restrictions obo:BFO_0000051op some obo:TXPO_0001165c

S-adenosylmethionine biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006556
Super-classes obo:GO_0009058c

lipid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006629
Super-classes obo:GO_0008152c
Restrictions obo:BFO_0000051op some obo:GO_0008610c
obo:BFO_0000051op some obo:GO_0016042c
Sub-classes obo:GO_0006631c
obo:GO_0006644c
obo:GO_0006665c

fatty acid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006631
Super-classes obo:GO_0006629c
Restrictions obo:BFO_0000051op some obo:GO_0009062c
obo:BFO_0000051op some obo:GO_0006633c
Sub-classes obo:GO_0001676c

fatty acid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006633
Super-classes obo:GO_0008610c

fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006635
Super-classes obo:GO_0019395c
Sub-classes obo:TXPO_0001100c
obo:TXPO_0001388c

phospholipid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006644
Super-classes obo:GO_0006629c
Restrictions obo:BFO_0000051op some obo:GO_0008654c
obo:BFO_0000051op some obo:GO_0009395c
Sub-classes obo:GO_0006650c
obo:GO_0006684c

phosphatidylethanolamine biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006646
Super-classes obo:GO_0046474c
Restrictions obo:RO_0002234op some obo:CHEBI_16038c

phospholipid transfer to membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0006649
Super-classes obo:GO_0015914c
Restrictions obo:RO_0002339op some obo:TXPO_0000895c

glycerophospholipid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006650
Super-classes obo:GO_0006644c
Restrictions obo:RO_0000057op some obo:CHEBI_37739c
Sub-classes obo:GO_0046475c
obo:GO_0046473c
obo:GO_0006658c
obo:GO_0046474c
obo:GO_0046470c
obo:GO_0046488c
obo:GO_0046471c

phosphatidic acid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006654
Super-classes obo:GO_0046474c
obo:GO_0046473c
Restrictions obo:RO_0002234op some obo:CHEBI_16337c

phosphatidylglycerol biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006655
Super-classes obo:GO_0046471c
obo:GO_0046474c
Restrictions obo:RO_0002234op some obo:CHEBI_17517c
Sub-classes obo:GO_0032049c

phosphatidylcholine biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006656
Super-classes obo:GO_0046474c
obo:GO_0046470c
Restrictions obo:RO_0002234op some obo:CHEBI_64482c

phosphatidylserine metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006658
Super-classes obo:GO_0006650c
Restrictions obo:RO_0000057op some obo:CHEBI_18303c
Sub-classes obo:GO_0006660c
obo:GO_0006659c

phosphatidylserine biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006659
Super-classes obo:GO_0046474c
obo:GO_0006658c
Restrictions obo:RO_0002234op some obo:CHEBI_18303c

phosphatidylserine catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006660
Super-classes obo:GO_0046475c
obo:GO_0006658c
Restrictions obo:RO_0002233op some obo:CHEBI_18303c

phosphatidylinositol biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006661
Description

Phosphatidylinositol (PI) is synthesized when phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-DAG) followed by conversion into PI and cytidine monophosphate (CMP) (Stuhne-Sekalec et al 1986, Lykidis et al. 1997).
Super-classes obo:GO_0046474c
obo:GO_0046488c
Restrictions obo:RO_0002234op some obo:CHEBI_28874c

sphingolipid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006665
Super-classes obo:GO_0006629c

sphingomyelin metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006684
Super-classes obo:GO_0006644c
Restrictions obo:RO_0000057op some obo:CHEBI_64583c
Sub-classes obo:GO_0006685c
obo:GO_0006686c

sphingomyelin catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006685
Super-classes obo:GO_0006684c
obo:TXPO_0001465c
Restrictions obo:RO_0002233op some obo:CHEBI_64583c

sphingomyelin biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006686
Super-classes obo:TXPO_0001291c
obo:GO_0006684c
Restrictions obo:RO_0002234op some obo:CHEBI_64583c
Sub-classes obo:TXPO_0003580c
obo:TXPO_0003579c

cholesterol biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006695
Super-classes obo:GO_0008610c
Sub-classes obo:TXPO_0003135c
obo:TXPO_0003332c

bile acid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006699
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:TXPO_0000509c
Sub-classes obo:TXPO_0000268c

estrogen catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006711
Super-classes obo:GO_0009056c
obo:GO_0008210c
Restrictions obo:RO_0002233op some (obo:BFO_0000040c and ub744bL12094C17c)

NADH regenerationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006735
Super-classes obo:GO_0009058c
Restrictions obo:RO_0000057op some obo:CHEBI_15846c
obo:RO_0002234op some obo:CHEBI_16908c

NADPH regenerationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006740
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_16474c
Sub-classes obo:TXPO_0002379c

glutathione metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006749
Super-classes obo:GO_0008152c
Sub-classes obo:TXPO_0003991c

glutathione biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006750
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_16856c
obo:TXPO_0002524op some obo:TXPO_0000652c
obo:TXPO_0002524op some obo:HINO_0016374c
Sub-classes obo:TXPO_0001194c

ATP biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006754
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_15422c
obo:BFO_0000051op some obo:GO_0042773c
obo:BFO_0000051op some obo:GO_0006119c
Sub-classes obo:TXPO_0003181c

heme biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006783
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_18248c

phosphorus metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006793
Super-classes obo:GO_0008152c
Sub-classes obo:GO_0016310c
obo:GO_0016311c

xenobiotic metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006805
Description

Xenobiotic biotransformation is metabolic conversion of xenobiotic chemicals to more hydrophilic (water-soluble) compounds.
Super-classes obo:GO_0008152c
Sub-classes obo:TXPO_0004294c
obo:GO_0017144c

transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0006810
Super-classes obo:TXPO_0000442c
Sub-classes obo:TXPO_0003355c
obo:TXPO_0000111c
obo:GO_0007041c
obo:GO_0015893c
obo:GO_0034635c
obo:GO_0022900c
obo:GO_0048193c
obo:GO_0055085c
obo:GO_0006811c
obo:TXPO_0003124c
obo:TXPO_0003188c
obo:GO_0006836c
obo:TXPO_0000460c
obo:GO_0015721c
obo:GO_0016192c
obo:GO_0051169c

ion transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0006811
Super-classes obo:GO_0006810c
obo:TXPO_0000111c
Sub-classes obo:GO_0006813c
obo:GO_1902600c

potassium ion transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0006813
Super-classes obo:GO_0006811c

neurotransmitter transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0006836
Super-classes obo:GO_0006810c

lipid transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0006869
Super-classes obo:TXPO_0000111c
Sub-classes obo:GO_0015908c
obo:GO_0030301c
obo:TXPO_0000131c
obo:GO_0015914c
obo:GO_0034197c

endocytosisc # Classes

URI http://purl.obolibrary.org/obo/GO_0006897
Super-classes obo:TXPO_0002587c

phagocytosisc # Classes

URI http://purl.obolibrary.org/obo/GO_0006909
Super-classes obo:TXPO_0002587c
Restrictions obo:BFO_0000051op some obo:GO_0001845c
obo:BFO_0000051op some obo:GO_0006910c
Sub-classes obo:TXPO_0000926c

phagocytosis, recognitionc # Classes

URI http://purl.obolibrary.org/obo/GO_0006910
Description

Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'.
Super-classes obo:TXPO_0000379c
Restrictions obo:BFO_0000050op some obo:GO_0006909c

nucleocytoplasmic transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0006913
Super-classes obo:GO_0051169c

autophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_0006914
Super-classes obo:GO_0009056c
Sub-classes obo:GO_0030242c
obo:TXPO_0004928c
obo:GO_0062093c
obo:TXPO_0000204c
obo:TXPO_0001298c
obo:TXPO_0000127c
obo:GO_0000422c
obo:TXPO_0004929c
obo:TXPO_0002445c

apoptotic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0006915
Super-classes obo:GO_0008219c
Restrictions obo:TXPO_0001868op some obo:CL_0000000c
Sub-classes obo:TXPO_0001992c
obo:TXPO_0000514c
obo:TXPO_0001087c
obo:TXPO_0003391c
obo:TXPO_0001026c
obo:TXPO_0000513c
obo:TXPO_0000515c
obo:TXPO_0002371c
obo:GO_0043276c
obo:TXPO_0000314c
obo:TXPO_0000089c

cell motilityc # Classes

URI http://purl.obolibrary.org/obo/GO_0006928
Super-classes obo:GO_0040011c
Restrictions obo:RO_0000057op some obo:CL_0000000c

response to stressc # Classes

URI http://purl.obolibrary.org/obo/GO_0006950
Super-classes obo:GO_0050896c
Sub-classes obo:GO_0006979c
obo:GO_0001666c
obo:GO_0034976c

immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0006955
Super-classes obo:GO_0050896c
Restrictions obo:BFO_0000051op some obo:TXPO_0003990c
obo:BFO_0000051op some obo:TXPO_0000296c
obo:BFO_0000051op some obo:TXPO_0003646c
Sub-classes obo:GO_0002418c
obo:GO_0002250c
obo:GO_0045087c
obo:GO_0002384c
obo:TXPO_0003646c

cellular response to DNA damage stimulusc # Classes

URI http://purl.obolibrary.org/obo/GO_0006974
Super-classes obo:GO_0050896c

response to oxidative stressc # Classes

URI http://purl.obolibrary.org/obo/GO_0006979
Super-classes obo:GO_0006950c

organelle organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0006996
Super-classes obo:GO_0071840c
Sub-classes obo:GO_0007010c

mitochondrion organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0007005
Super-classes obo:TXPO_0000468c
Restrictions obo:BFO_0000066op some obo:GO_0005739c

cytoskeleton organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0007010
Super-classes obo:GO_0006996c
Sub-classes obo:GO_0030036c

actin filament organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0007015
Super-classes obo:GO_0030036c

cytoplasm organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0007028
Super-classes obo:GO_0071840c

vacuole organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0007033
Super-classes obo:GO_0071840c
Sub-classes obo:TXPO_0002339c

lysosomal transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0007041
Super-classes obo:GO_0006810c

cell cyclec # Classes

URI http://purl.obolibrary.org/obo/GO_0007049
Super-classes obo:TXPO_0000425c

cell cycle arrestc # Classes

URI http://purl.obolibrary.org/obo/GO_0007050
Super-classes obo:TXPO_0003798c
Restrictions obo:RO_0002212op some obo:GO_0007049c
Sub-classes obo:TXPO_0002116c
obo:TXPO_0004376c

cell adhesionc # Classes

URI http://purl.obolibrary.org/obo/GO_0007155
Super-classes obo:TXPO_0002581c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
obo:RO_0000057op some obo:CL_0000000c

epidermal growth factor receptor signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0007173
Super-classes obo:TXPO_0000609c

transforming growth factor beta receptor signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0007179
Super-classes obo:TXPO_0000609c

Notch signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0007219
Super-classes obo:TXPO_0000609c

I-kappaB kinase/NF-kappaB signalingc # Classes

URI http://purl.obolibrary.org/obo/GO_0007249
Super-classes obo:TXPO_0000027c
Restrictions obo:BFO_0000051op some obo:TXPO_0002779c
obo:BFO_0000051op some obo:TXPO_0002785c
obo:BFO_0000051op some obo:TXPO_0002783c
obo:BFO_0000051op some obo:TXPO_0002789c
obo:BFO_0000051op some obo:TXPO_0002781c

cytoplasmic sequestering of NF-kappaBc # Classes

URI http://purl.obolibrary.org/obo/GO_0007253
Super-classes obo:TXPO_0000433c
Sub-classes obo:TXPO_0002789c

feeding behaviorc # Classes

URI http://purl.obolibrary.org/obo/GO_0007631
Super-classes obo:TXPO_0002587c
Sub-classes obo:TXPO_0001542c

metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0008152
Description

Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
Super-classes obo:TXPO_0000261c
Sub-classes obo:GO_0006066c
obo:GO_0005975c
obo:GO_0006091c
obo:GO_0019538c
obo:GO_0070085c
obo:GO_0032259c
obo:GO_0006805c
obo:GO_0019585c
obo:GO_0042445c
obo:GO_0006305c
obo:GO_0009404c
obo:GO_0006629c
obo:GO_0044281c
obo:GO_0006793c
obo:TXPO_0000283c
obo:GO_0046034c
obo:GO_0055114c
obo:GO_0006099c
obo:GO_0070988c
obo:GO_0006555c
obo:GO_0006749c

estrogen metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0008210
Super-classes obo:GO_0042445c
Sub-classes obo:GO_0006711c

cell deathc # Classes

URI http://purl.obolibrary.org/obo/GO_0008219
Super-classes obo:TXPO_0000437c
Restrictions obo:RO_0002233op some obo:CL_0000000c
Sub-classes obo:TXPO_0000814c
obo:TXPO_0000008c
obo:TXPO_0000520c
obo:GO_0070265c
obo:TXPO_0003568c
obo:GO_0006915c
obo:GO_0097707c
obo:TXPO_0001204c
obo:TXPO_0002149c
obo:TXPO_0000927c
obo:GO_0070269c
obo:TXPO_0004129c

cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_0008283
Description

This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
Super-classes obo:TXPO_0000093c
Restrictions obo:TXPO_0001868op some obo:CL_0000000c
obo:RO_0002234op some (obo:CL_0000000c and ub744bL12524C17c)
obo:BFO_0000066op some obo:UBERON_0000062c
Sub-classes obo:TXPO_0001490c
obo:TXPO_0000339c
obo:GO_0046651c
obo:NCIT_C20613c
obo:TXPO_0002173c
obo:GO_1990922c
obo:TXPO_0000831c
obo:GO_0072574c
obo:TXPO_0004898c
obo:TXPO_0003286c
obo:TXPO_0000961c
obo:TXPO_0001427c
obo:TXPO_0000338c

insulin receptor signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0008286
Super-classes obo:TXPO_0000027c
Sub-classes obo:TXPO_0000993c

lipid bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0008289
Super-classes obo:GO_0005488c
Sub-classes obo:GO_0005543c
obo:GO_0017129c
obo:GO_0005504c

RNA splicingc # Classes

URI http://purl.obolibrary.org/obo/GO_0008380
Super-classes obo:TXPO_0000333c
Sub-classes obo:TXPO_0001015c
obo:TXPO_0000725c

phosphatidylethanolamine bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0008429
Super-classes obo:GO_0005543c

lipid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0008610
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_18059c
Sub-classes obo:GO_0046513c
obo:GO_0009247c
obo:TXPO_0004372c
obo:GO_0006633c
obo:GO_0006695c
obo:TXPO_0002163c
obo:TXPO_0001141c
obo:GO_0008654c

extrinsic apoptotic signaling pathway via death domain receptorsc # Classes

URI http://purl.obolibrary.org/obo/GO_0008625
Super-classes obo:TXPO_0000611c
Sub-classes obo:TXPO_0003061c

carbohydrate transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0008643
Super-classes obo:TXPO_0000111c
Sub-classes obo:TXPO_0000932c

phospholipid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0008654
Super-classes obo:GO_0008610c
Restrictions obo:RO_0002234op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0003387c
obo:TXPO_0001291c
obo:GO_0046474c
obo:TXPO_0005189c

catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0009056
Super-classes obo:TXPO_0000185c
Sub-classes obo:GO_0006402c
obo:GO_0016052c
obo:GO_0016042c
obo:GO_0006711c
obo:GO_0006914c
obo:GO_0030163c
obo:TXPO_0000114c
obo:GO_0006308c
obo:TXPO_0001165c

biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0009058
Super-classes obo:TXPO_0000019c
Restrictions obo:BFO_0000051op some obo:TXPO_0000387c
Sub-classes obo:GO_0042089c
obo:GO_00042181c
obo:GO_0006556c
obo:GO_0071897c
obo:GO_0006735c
obo:GO_0016051c
obo:GO_0009236c
obo:GO_0006740c
obo:TXPO_0000306c
obo:GO_0006783c
obo:GO_0006754c
obo:TXPO_0000205c
obo:TXPO_0000209c
obo:GO_0006750c
obo:GO_0006699c
obo:TXPO_0000212c
obo:TXPO_0000210c
obo:GO_1903409c
obo:TXPO_0002552c
obo:GO_0008610c

fatty acid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0009062
Super-classes obo:GO_0016042c
Restrictions obo:RO_0002233op some obo:TXPO_0000834c
obo:BFO_0000051op some obo:GO_0019395c

cobalamin biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0009236
Super-classes obo:GO_0009058c

glycolipid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0009247
Super-classes obo:GO_0008610c
Sub-classes obo:TXPO_0000693c

attenuation of translationc # Classes

URI http://purl.obolibrary.org/obo/GO_0009386
Super-classes obo:GO_0006417c
Restrictions obo:RO_0002212op some obo:GO_0006412c
Sub-classes obo:TXPO_0000722c

phospholipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0009395
Super-classes obo:GO_0016042c
Restrictions obo:RO_0002233op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0001406c
obo:TXPO_0001465c
obo:TXPO_0000393c
obo:GO_0046475c

toxin metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0009404
Super-classes obo:GO_0008152c
Sub-classes obo:GO_0046222c

response to external stimulusc # Classes

URI http://purl.obolibrary.org/obo/GO_0009605
Description

Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
Super-classes obo:GO_0050896c

response to endogenous stimulusc # Classes

URI http://purl.obolibrary.org/obo/GO_0009719
Description

Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
Super-classes obo:GO_0050896c

membrane invaginationc # Classes

URI http://purl.obolibrary.org/obo/GO_0010324
Super-classes obo:TXPO_0002587c
Sub-classes obo:GO_0061736c
obo:GO_0099024c

gene expressionc # Classes

URI http://purl.obolibrary.org/obo/GO_0010467
Description

A changing process to convert a gene's sequenes into a mature gene prduct(s), i.e., (m)RNA, or protein.
Super-classes obo:TXPO_0002282c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000382c
Sub-classes obo:TXPO_0001611c
obo:TXPO_0001383c
obo:GO_0006351c
obo:TXPO_0003383c
obo:GO_0006412c
obo:TXPO_0000375c
obo:TXPO_0003398c
obo:TXPO_0001626c
obo:TXPO_0002224c
obo:TXPO_0003071c
obo:TXPO_0000703c
obo:TXPO_0000296c
obo:TXPO_0000399c
obo:TXPO_0002334c
obo:TXPO_0002917c
obo:TXPO_0002061c
obo:TXPO_0000706c
obo:TXPO_0002266c
obo:TXPO_0000175c
obo:TXPO_0001381c
obo:TXPO_0001300c
obo:TXPO_0000727c

regulation of gene expressionc # Classes

URI http://purl.obolibrary.org/obo/GO_0010468
Description

This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0010467c
obo:BFO_0000051op some obo:GO_0010629c
obo:BFO_0000051op some obo:GO_0010628c
Sub-classes obo:TXPO_0000585c
obo:TXPO_0000183c
obo:TXPO_0002545c
obo:TXPO_0003937c
obo:TXPO_0002784c
obo:TXPO_0000119c
obo:GO_0040029c
obo:TXPO_0002136c
obo:TXPO_0000667c
obo:GO_0035195c
obo:TXPO_0003139c
obo:TXPO_0000195c

proteasomal protein catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0010498
Super-classes obo:GO_0030163c
Sub-classes obo:GO_0043161c
obo:GO_0036503c

regulation of autophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_0010506
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0006914c
Sub-classes obo:GO_0010508c
obo:TXPO_0000755c
obo:GO_0010507c
obo:GO_1901524c

negative regulation of autophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_0010507
Super-classes obo:GO_0010506c
Restrictions obo:RO_0002212op some obo:GO_0006914c
Sub-classes obo:TXPO_0002323c
obo:TXPO_0001258c
obo:TXPO_0004679c
obo:TXPO_0002128c
obo:TXPO_0001018c

positive regulation of autophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_0010508
Super-classes obo:GO_0010506c
Restrictions obo:RO_0002213op some obo:GO_0006914c
Sub-classes obo:TXPO_0004442c
obo:TXPO_0001455c
obo:TXPO_0000757c
obo:TXPO_0003877c
obo:TXPO_0003478c
obo:TXPO_0000406c

positive regulation of gene expressionc # Classes

URI http://purl.obolibrary.org/obo/GO_0010628
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0010467c
Sub-classes obo:TXPO_0002756c
obo:TXPO_0003116c

negative regulation of gene expressionc # Classes

URI http://purl.obolibrary.org/obo/GO_0010629
Description

This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0010467c
obo:BFO_0000051op some obo:GO_0045892c
obo:BFO_0000051op some obo:GO_0009386c
Sub-classes obo:TXPO_0002057c
obo:TXPO_0003455c
obo:TXPO_0002001c
obo:TXPO_0003218c
obo:TXPO_0003940c
obo:TXPO_0003013c

negative regulation of extracellular matrix disassemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0010716
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0022411c
Sub-classes obo:TXPO_0003761c

macrophage derived foam cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0010742
Super-classes obo:GO_0090077c

regulation of macrophage derived foam cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0010743
Super-classes obo:GO_0045595c
Sub-classes obo:GO_0010745c
obo:GO_0010744c

positive regulation of macrophage derived foam cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0010744
Super-classes obo:GO_0010743c
Restrictions obo:TXPO_0000716op some obo:GO_0010742c
Sub-classes obo:TXPO_0004085c

negative regulation of macrophage derived foam cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0010745
Super-classes obo:GO_0010743c

cholesterol storagec # Classes

URI http://purl.obolibrary.org/obo/GO_0010878
Super-classes obo:GO_0019915c
Restrictions obo:RO_0002233op some obo:CHEBI_16113c
Sub-classes obo:TXPO_0001537c
obo:TXPO_0004991c

negative regulation of lipid storagec # Classes

URI http://purl.obolibrary.org/obo/GO_0010888
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0019915c
Sub-classes obo:TXPO_0000130c

negative regulation of phosphatidylcholine catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0010900
Super-classes obo:TXPO_0001304c
Sub-classes obo:TXPO_0000621c

regulation of cell deathc # Classes

URI http://purl.obolibrary.org/obo/GO_0010941
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0008219c
Sub-classes obo:TXPO_0004079c
obo:TXPO_0004082c

bile acid and bile salt transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015721
Super-classes obo:GO_0006810c
Sub-classes obo:TXPO_0000269c
obo:TXPO_0002693c
obo:GO_0015722c

canalicular bile acid transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015722
Super-classes obo:GO_0015721c
Sub-classes obo:TXPO_0000336c

choline transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015871
Super-classes obo:TXPO_0000111c
Sub-classes obo:TXPO_0001320c

drug transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015893
Super-classes obo:GO_0006810c

fatty acid transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015908
Super-classes obo:GO_0006869c
Sub-classes obo:GO_0015909c

long-chain fatty acid transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015909
Super-classes obo:GO_0015908c
Sub-classes obo:TXPO_0004986c
obo:GO_0015910c

long-chain fatty acid import into peroxisomec # Classes

URI http://purl.obolibrary.org/obo/GO_0015910
Super-classes obo:GO_0015909c
Sub-classes obo:TXPO_0000109c

phospholipid transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015914
Super-classes obo:GO_0006869c
Sub-classes obo:GO_0006649c
obo:TXPO_0003388c

electron transport coupled proton transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0015990
Super-classes obo:GO_1902600c

lipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0016042
Super-classes obo:GO_0009056c
Restrictions obo:RO_0002233op some obo:CHEBI_18059c
Sub-classes obo:TXPO_0001220c
obo:GO_0009395c
obo:TXPO_0000187c
obo:TXPO_0000071c
obo:GO_0009062c

cell growthc # Classes

URI http://purl.obolibrary.org/obo/GO_0016049
Super-classes obo:GO_0040007c
Sub-classes obo:TXPO_0001578c
obo:TXPO_0000766c
obo:TXPO_0003319c

carbohydrate biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0016051
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_16646c
Sub-classes obo:GO_0006094c
obo:TXPO_0004371c
obo:GO_0005978c

carbohydrate catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0016052
Super-classes obo:GO_0009056c
Restrictions obo:RO_0002233op some obo:CHEBI_16646c
Sub-classes obo:GO_0006096c
obo:GO_0005980c

vesicle-mediated transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0016192
Super-classes obo:GO_0006810c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:TXPO_0003133c
obo:GO_0016197c

endosomal transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0016197
Super-classes obo:GO_0016192c
Sub-classes obo:GO_0032456c

gap junction assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0016264
Super-classes obo:GO_0034329c

phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0016310
Super-classes obo:GO_0006793c
Sub-classes obo:TXPO_0002495c
obo:GO_0046777c
obo:TXPO_0001392c
obo:TXPO_0004995c
obo:GO_0006119c
obo:TXPO_0001899c

dephosphorylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0016311
Super-classes obo:GO_0006793c
Sub-classes obo:TXPO_0002752c

cell migrationc # Classes

URI http://purl.obolibrary.org/obo/GO_0016477
Super-classes obo:TXPO_0000003c
Sub-classes obo:GO_0050900c
obo:TXPO_0005045c
obo:TXPO_0000763c
obo:NCIT_C19151c

protein processingc # Classes

URI http://purl.obolibrary.org/obo/GO_0016485
Super-classes obo:GO_0006508c
Sub-classes obo:TXPO_0001063c
obo:TXPO_0003063c
obo:GO_0030908c
obo:TXPO_0003766c

protein deubiquitinationc # Classes

URI http://purl.obolibrary.org/obo/GO_0016579
Super-classes obo:GO_0070646c

protein sumoylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0016925
Super-classes obo:TXPO_0004107c

triglyceride bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0017129
Description

Interacting selectively and non-covalently with any triester of glycerol.
Super-classes obo:GO_0008289c

drug metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0017144
Super-classes obo:GO_0006805c
Sub-classes obo:TXPO_0000173c
obo:TXPO_0001584c
obo:TXPO_0001591c

protein myristoylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0018377
Super-classes obo:GO_0006497c

protein glucuronidationc # Classes

URI http://purl.obolibrary.org/obo/GO_0018411
Super-classes obo:GO_0036211c

regulation of lipid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0019216
Super-classes obo:GO_0019222c
Restrictions obo:RO_0002211op some obo:GO_0006629c
Sub-classes obo:TXPO_0000116c

regulation of metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0019222
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0008152c
Sub-classes obo:GO_0006109c
obo:GO_0019216c

fatty acid oxidationc # Classes

URI http://purl.obolibrary.org/obo/GO_0019395
Super-classes obo:GO_0034440c
Sub-classes obo:GO_0006635c
obo:TXPO_0000112c
obo:TXPO_0000097c

protein metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0019538
Super-classes obo:GO_0008152c
Restrictions obo:BFO_0000051op some obo:TXPO_0000306c
obo:RO_0000057op some obo:CHEBI_36080c
obo:BFO_0000051op some obo:GO_0030163c
Sub-classes obo:GO_0036211c

glucuronate metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0019585
Super-classes obo:GO_0008152c
Sub-classes obo:GO_0052697c

cytolysisc # Classes

URI http://purl.obolibrary.org/obo/GO_0019835
Super-classes obo:TXPO_0000437c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:TXPO_0004830c

lipid storagec # Classes

URI http://purl.obolibrary.org/obo/GO_0019915
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_18059c
Sub-classes obo:TXPO_0000256c
obo:TXPO_0003623c
obo:TXPO_0004959c
obo:GO_0010878c
obo:TXPO_0001276c
obo:GO_0030730c
obo:TXPO_0001244c
obo:TXPO_0004143c

cell cycle phasec # Classes

URI http://purl.obolibrary.org/obo/GO_0022403
Super-classes obo:PATO_0000083c
Sub-classes obo:GO_0051319c
obo:GO_0051318c
obo:GO_0044838c
obo:GO_0000279c
obo:GO_0051320c

extracellular matrix disassemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0022411
Super-classes obo:TXPO_0000343c
Restrictions obo:RO_0002233op some obo:GO_0031012c
Sub-classes obo:TXPO_0004144c

cellular component assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0022607
Super-classes obo:TXPO_0000468c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:GO_0034333c

electron transport chainc # Classes

URI http://purl.obolibrary.org/obo/GO_0022900
Super-classes obo:GO_0055114c
obo:GO_0006810c
Sub-classes obo:GO_0022904c

respiratory electron transport chainc # Classes

URI http://purl.obolibrary.org/obo/GO_0022904
Super-classes obo:GO_0022900c
Sub-classes obo:GO_0042773c
obo:GO_0006121c
obo:GO_0006120c
obo:GO_0006122c

regulation of signalingc # Classes

URI http://purl.obolibrary.org/obo/GO_0023051
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:TXPO_0000471c

signaling [biological] (primitive)c # Classes

URI http://purl.obolibrary.org/obo/GO_0023052
Description

Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
Super-classes obo:TXPO_0000471c
Restrictions obo:BFO_0000051op some obo:TXPO_0000020c
Sub-classes obo:TXPO_0004724c
obo:TXPO_0004301c
obo:TXPO_0004535c
obo:TXPO_0004663c
obo:TXPO_0000447c
obo:TXPO_0004531c
obo:TXPO_0005065c
obo:TXPO_0001492c
obo:TXPO_0000444c
obo:TXPO_0004327c
obo:TXPO_0000274c
obo:TXPO_0000769c
obo:TXPO_0004860c
obo:TXPO_0004539c
obo:TXPO_0004303c
obo:TXPO_0000604c
obo:TXPO_0004495c
obo:TXPO_0004548c
obo:TXPO_0000477c
obo:TXPO_0004599c
obo:TXPO_0004824c
obo:TXPO_0001795c
obo:TXPO_0001494c
obo:TXPO_0004554c
obo:TXPO_0004451c
obo:TXPO_0004871c
obo:TXPO_0004868c
obo:TXPO_0004848c
obo:TXPO_0004696c
obo:TXPO_0004810c
obo:TXPO_0004832c
obo:TXPO_0004667c
obo:TXPO_0004576c
obo:TXPO_0000761c
obo:TXPO_0000335c
obo:TXPO_0004424c
obo:TXPO_0004629c
obo:TXPO_0004807c
obo:TXPO_0004839c
obo:TXPO_0004637c
obo:TXPO_0001854c
obo:TXPO_0003237c
obo:TXPO_0004875c
obo:TXPO_0004657c
obo:TXPO_0000001c
obo:TXPO_0004028c
obo:TXPO_0004814c
obo:TXPO_0000449c
obo:TXPO_0000720c
obo:TXPO_0004481c
obo:TXPO_0004545c
obo:TXPO_0004752c
obo:TXPO_0000830c

negative regulation of signalingc # Classes

URI http://purl.obolibrary.org/obo/GO_0023057
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0023052c
obo:RO_0002212op some obo:TXPO_0000609c
Sub-classes obo:TXPO_0002102c
obo:TXPO_0004425c
obo:TXPO_0004840c
obo:TXPO_0004532c
obo:TXPO_0004496c
obo:GO_0042059c
obo:GO_0030512c
obo:GO_0051898c
obo:GO_1901797c

lamellipodium biogenesisc # Classes

URI http://purl.obolibrary.org/obo/GO_0030032
Super-classes obo:GO_0071840c

actin cytoskeleton organization and biogenesisc # Classes

URI http://purl.obolibrary.org/obo/GO_0030036
Super-classes obo:GO_0007010c
Sub-classes obo:GO_0031532c
obo:GO_0007015c

insulin secretionc # Classes

URI http://purl.obolibrary.org/obo/GO_0030073
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:IMR_0000052c

protein repairc # Classes

URI http://purl.obolibrary.org/obo/GO_0030091
Super-classes obo:TXPO_0000535c

lymphocyte differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0030098
Description

Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Super-classes obo:GO_0002521c
Sub-classes obo:GO_0030217c

natural killer cell activationc # Classes

URI http://purl.obolibrary.org/obo/GO_0030101
Super-classes obo:GO_0046649c
Sub-classes obo:TXPO_0000073c

cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0030154
Super-classes obo:TXPO_0002282c
Restrictions obo:TXPO_0001868op some obo:CL_0000000c
obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:GO_0001837c
obo:GO_0002521c
obo:GO_0045444c
obo:GO_0090077c
obo:GO_0030855c
obo:GO_0060290c
obo:OMIT_0003800c

protein catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0030163
Description

This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
Super-classes obo:GO_0009056c
Restrictions obo:RO_0002233op some obo:CHEBI_36080c
Sub-classes obo:GO_0010498c
obo:TXPO_0002758c
obo:TXPO_0003898c
obo:TXPO_0000516c

extracellular matrix organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0030198
Super-classes obo:TXPO_0000468c
Sub-classes obo:TXPO_0003759c

T cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0030217
Super-classes obo:GO_0030098c
Sub-classes obo:GO_0001865c

macrophage differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0030225
Super-classes obo:GO_0002521c
Sub-classes obo:TXPO_0003430c

autophagy of peroxisomec # Classes

URI http://purl.obolibrary.org/obo/GO_0030242
Super-classes obo:GO_0006914c
Restrictions obo:RO_0002233op some obo:GO_0005777c
Sub-classes obo:GO_0000425c

cholesterol transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0030301
Super-classes obo:GO_0006869c
Sub-classes obo:GO_0090117c

negative regulation of transforming growth factor beta receptor signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0030512
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:GO_0007179c
obo:RO_0002212op some obo:TXPO_0001854c

leukocyte chemotaxisc # Classes

URI http://purl.obolibrary.org/obo/GO_0030595
Super-classes obo:GO_0050900c

sequestering of triglyceridec # Classes

URI http://purl.obolibrary.org/obo/GO_0030730
Super-classes obo:GO_0019915c
Restrictions obo:RO_0002233op some obo:CHEBI_17855c
Sub-classes obo:TXPO_0001522c

epithelial cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0030855
Super-classes obo:GO_0030154c
Sub-classes obo:GO_0045446c

protein splicingc # Classes

URI http://purl.obolibrary.org/obo/GO_0030908
Super-classes obo:GO_0016485c

endoplasmic reticulum unfolded protein responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0030968
Description

Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
Super-classes obo:GO_0034976c

retrograde protein transport, ER to cytosolc # Classes

URI http://purl.obolibrary.org/obo/GO_0030970
Super-classes obo:TXPO_0000111c
Restrictions obo:RO_0002338op some obo:GO_0005783c
obo:RO_0002339op some obo:GO_0005829c
Sub-classes obo:TXPO_0000456c

extracellular matrixc # Classes

URI http://purl.obolibrary.org/obo/GO_0031012
Super-classes obo:TXPO_0000065c

organelle membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0031090
Super-classes obo:TXPO_0000895c
Sub-classes obo:GO_0031966c
obo:GO_0005765c
obo:GO_0031965c
obo:GO_0005789c

stress-activated protein kinase signaling cascadec # Classes

URI http://purl.obolibrary.org/obo/GO_0031098
Super-classes obo:TXPO_0000609c
Restrictions obo:BFO_0000051op some obo:TXPO_0000769c

phosphatidylinositol catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0031161
Super-classes obo:GO_0046488c
obo:GO_0046475c
Restrictions obo:RO_0002233op some obo:CHEBI_28874c

phosphatidylcholine bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0031210
Super-classes obo:GO_0005543c

negative regulation of protein complex assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0031333
Super-classes obo:TXPO_0004212c
Restrictions obo:RO_0002212op some obo:GO_0006461c

actin cytoskeleton reorganizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0031532
Super-classes obo:GO_0030036c
Sub-classes obo:TXPO_0004874c

heat generationc # Classes

URI http://purl.obolibrary.org/obo/GO_0031649
Super-classes obo:TXPO_0000381c

TOR signalingc # Classes

URI http://purl.obolibrary.org/obo/GO_0031929
Super-classes obo:TXPO_0000609c

nuclear membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0031965
Super-classes obo:GO_0031090c

mitochondrial membranec # Classes

URI http://purl.obolibrary.org/obo/GO_0031966
Super-classes obo:GO_0031090c
Restrictions obo:RO_0000086op some obo:PATO_0000970c
Sub-classes obo:GO_0005741c
obo:GO_0005743c

vesiclec # Classes

URI http://purl.obolibrary.org/obo/GO_0031982
Super-classes obo:GO_0043227c
Restrictions obo:BFO_0000050op some obo:GO_0005737c
Sub-classes obo:GO_0048770c
obo:GO_0005768c

mitochondrial DNA catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0032043
Super-classes obo:GO_0006308c
Restrictions obo:RO_0002233op only efo:EFO_0008480c
Sub-classes obo:TXPO_0004262c

cardiolipin biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0032049
Super-classes obo:GO_0006655c
Restrictions obo:RO_0002234op some obo:CHEBI_28494c

bleb assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0032060
Super-classes obo:GO_0071840c
Sub-classes obo:TXPO_0000231c

methylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0032259
Super-classes obo:GO_0008152c
Sub-classes obo:GO_0006306c

endocytic recyclingc # Classes

URI http://purl.obolibrary.org/obo/GO_0032456
Super-classes obo:GO_0016197c

chemokine productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032602
Super-classes obo:GO_0001816c
Sub-classes obo:TXPO_0004478c
obo:GO_0071610c
obo:GO_0071606c
obo:GO_0097390c
obo:TXPO_0004288c

type I interferon productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032606
Super-classes obo:GO_0001816c

interferon-gamma productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032609
Super-classes obo:GO_0001816c

IL-1 beta productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032611
Super-classes obo:GO_0001816c
Restrictions obo:TXPO_0001868op some obo:CL_0000091c
Sub-classes obo:TXPO_0004346c
obo:TXPO_0001878c

interleukin-1 productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032612
Super-classes obo:GO_0001816c

interleukin-2 productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032623
Super-classes obo:GO_0001816c

tumor necrosis factor productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032640
Super-classes obo:GO_0071706c
Sub-classes obo:TXPO_0004254c

bile acid secretionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032782
Description

Bile contains bile acids, glutathione, phospholipids, cholesterol, bilirubin, and other organic anions, proteins, metals, ions, and xenobiotics.

Hepatocytes begins the formation of bile by transporting bile acids, glutathione, and other solutes including Xenobiotics and their metabolites into the canalicular lumen.

The major driving force of bile formation is the active transport of bile salts and other osmolytes into the canalicular lumen.

Most conjugated bile acids (taurine and glycine conjugates) and some unconjugated bile acids are transported into hepatocytes by sodium-dependent transporters.

Sodium-independent uptake of conjugated and unconjugated bile acids is performed by members of the organic anion-transporting polypeptides (OATPs). OATPs also transport numerous drugs and hepatotoxicants.

Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids.

Conjugates of glutathione, glucuronide, and sulfate are exported by multidrug resistance-associated protein2 (MRP2).
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:TXPO_0000509c
Sub-classes obo:TXPO_0002649c

transforming growth factor beta1 productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0032905
Super-classes obo:GO_0001816c

mitochondrial respiratory chain complex I assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0032981
Super-classes obo:GO_0033108c
Restrictions obo:BFO_0000066op some obo:GO_0005739c

mitochondrial respiratory chain complex assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0033108
Super-classes obo:GO_0065003c
Restrictions obo:BFO_0000050op some obo:GO_0007005c
Sub-classes obo:GO_0032981c
obo:GO_0034553c
obo:GO_0033617c
obo:GO_0034551c

tumor necrosis factor-mediated signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0033209
Super-classes obo:TXPO_0000609c

cholesterol effluxc # Classes

URI http://purl.obolibrary.org/obo/GO_0033344
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:CHEBI_16113c
Sub-classes obo:TXPO_0002614c
obo:TXPO_0001457c

mitochondrial respiratory chain complex IV assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0033617
Super-classes obo:GO_0033108c
Restrictions obo:BFO_0000066op some obo:GO_0005739c

phospholipid effluxc # Classes

URI http://purl.obolibrary.org/obo/GO_0033700
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0002627c

TLR4 signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0034142
Super-classes obo:GO_0002224c

TLR9 signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0034162
Super-classes obo:GO_0002224c

triglyceride transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0034197
Super-classes obo:GO_0006869c
Sub-classes obo:TXPO_0003486c

cell junction assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0034329
Super-classes obo:TXPO_0000468c
Sub-classes obo:GO_0016264c

adherens junction assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0034333
Super-classes obo:GO_0022607c

very-low-density lipoprotein particle assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0034379
Super-classes obo:GO_0065005c
Restrictions obo:RO_0002234op some obo:CHEBI_39027c
Sub-classes obo:TXPO_0001281c

lipid droplet organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0034389
Super-classes obo:TXPO_0000468c
Sub-classes obo:TXPO_0004110c

lipid oxidationc # Classes

URI http://purl.obolibrary.org/obo/GO_0034440
Super-classes obo:GO_0055114c
Sub-classes obo:TXPO_0003514c
obo:GO_0019395c

phosphatidylglycerol catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0034478
Super-classes obo:GO_0046471c
obo:GO_0046475c
Restrictions obo:RO_0002233op some obo:CHEBI_17517c

mitochondrial respiratory chain complex III assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0034551
Super-classes obo:GO_0033108c
Restrictions obo:BFO_0000066op some obo:GO_0005739c

mitochondrial respiratory chain complex II assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0034553
Super-classes obo:GO_0033108c
Restrictions obo:BFO_0000066op some obo:GO_0005739c

glutathione transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0034635
Super-classes obo:GO_0006810c
Sub-classes obo:TXPO_0004983c
obo:TXPO_0002488c

phosphatidylcholine catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0034638
Super-classes obo:GO_0046470c
obo:GO_0046475c
Restrictions obo:RO_0002233op some obo:CHEBI_64482c

response to endoplasmic reticulum stressc # Classes

URI http://purl.obolibrary.org/obo/GO_0034976
Super-classes obo:GO_0006950c
Sub-classes obo:TXPO_0000735c
obo:GO_0030968c
obo:TXPO_0005026c

gene silencing by miRNAc # Classes

URI http://purl.obolibrary.org/obo/GO_0035195
Super-classes obo:GO_0010468c

helper T cell enhancement of adaptive immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0035397
Super-classes obo:GO_0002250c

protein deacylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0035601
Super-classes obo:GO_0036211c
Sub-classes obo:GO_0006476c

hepatic stellate cell activationc # Classes

URI http://purl.obolibrary.org/obo/GO_0035733
Super-classes obo:GO_0001775c
Restrictions obo:RO_0002233op some obo:CL_0000632c
Sub-classes obo:TXPO_0003746c
obo:TXPO_0004344c

positive regulation of mitochondrial membrane permeabilityc # Classes

URI http://purl.obolibrary.org/obo/GO_0035794
Super-classes obo:TXPO_0001223c
Restrictions obo:BFO_0000066op some obo:GO_0031966c
obo:RO_0002213op some obo:TXPO_0000799c
Sub-classes obo:TXPO_0000233c
obo:TXPO_0000234c
obo:TXPO_0001991c
obo:TXPO_0000981c
obo:TXPO_0000546c
obo:TXPO_0001083c
obo:TXPO_0001207c

long-chain fatty acid bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0036041
Super-classes obo:GO_0005504c

long-chain fatty acyl-CoA bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0036042
Super-classes obo:GO_0000062c
Restrictions obo:RO_0002233op some obo:CHEBI_33184c

protein modification processc # Classes

URI http://purl.obolibrary.org/obo/GO_0036211
Super-classes obo:GO_0019538c
Sub-classes obo:GO_0006517c
obo:GO_0018411c
obo:GO_0006497c
obo:GO_0035601c
obo:GO_0070647c
obo:GO_0043543c

Fas signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0036337
Super-classes obo:TXPO_0000609c

IRE1-mediated unfolded protein responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0036498
Super-classes obo:TXPO_0002155c
Sub-classes obo:TXPO_0002487c

PERK-mediated unfolded protein responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0036499
Super-classes obo:TXPO_0000285c
Sub-classes obo:TXPO_0002145c

ATF6-mediated unfolded protein responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0036500
Super-classes obo:TXPO_0002126c
Sub-classes obo:TXPO_0002143c

ERAD pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0036503
Description

ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
Super-classes obo:GO_0010498c
Sub-classes obo:GO_0071712c

interleukin-2-mediated signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0038110
Super-classes obo:TXPO_0000609c

CCL2 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0038151
Super-classes obo:TXPO_0000609c

growthc # Classes

URI http://purl.obolibrary.org/obo/GO_0040007
Super-classes obo:TXPO_0000138c
Sub-classes obo:GO_0016049c

locomotionc # Classes

URI http://purl.obolibrary.org/obo/GO_0040011
Super-classes obo:TXPO_0000765c
Sub-classes obo:GO_0006928c

regulation of gene expression, epigeneticc # Classes

URI http://purl.obolibrary.org/obo/GO_0040029
Super-classes obo:GO_0010468c

protein refoldingc # Classes

URI http://purl.obolibrary.org/obo/GO_0042026
Super-classes obo:GO_0006457c
Sub-classes obo:TXPO_0002175c
obo:TXPO_0002207c

negative regulation of epidermal growth factor receptor signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0042059
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:GO_0007173c
obo:RO_0002212op some obo:TXPO_0001492c
Sub-classes obo:TXPO_0003905c

cytokine biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0042089
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some (obo:BFO_0000040c and ub744bL13977C17c)

T cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_0042098
Super-classes obo:GO_0046651c

B cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_0042100
Super-classes obo:GO_0046651c

T cell activationc # Classes

URI http://purl.obolibrary.org/obo/GO_0042110
Super-classes obo:GO_0046649c

macrophage activationc # Classes

URI http://purl.obolibrary.org/obo/GO_0042116
Super-classes obo:GO_0045321c
Sub-classes obo:TXPO_0003184c
obo:TXPO_0004277c

lipoprotein biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0042158
Super-classes obo:TXPO_0000306c

negative regulation of protein catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0042177
Super-classes obo:TXPO_0000115c
Restrictions obo:RO_0002212op some obo:GO_0030163c
Sub-classes obo:TXPO_0000874c
obo:GO_1901799c

RNA repairc # Classes

URI http://purl.obolibrary.org/obo/GO_0042245
Super-classes obo:TXPO_0000535c

tissue regenerationc # Classes

URI http://purl.obolibrary.org/obo/GO_0042246
Super-classes obo:TXPO_0002590c
Sub-classes obo:TXPO_0005037c

hormone metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0042445
Super-classes obo:GO_0008152c
Sub-classes obo:GO_0008210c

microbodyc # Classes

URI http://purl.obolibrary.org/obo/GO_0042579
Super-classes obo:GO_0043227c
Sub-classes obo:GO_0005777c

homeostatic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0042592
Super-classes obo:TXPO_0000682c
Sub-classes obo:GO_0055091c
obo:TXPO_0001164c
obo:GO_0048878c
obo:TXPO_0000470c
obo:TXPO_0003552c

ATP synthesis coupled electron transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0042773
Super-classes obo:GO_0022904c
Sub-classes obo:GO_0042775c

mitochondrial ATP synthesis coupled electron transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0042775
Super-classes obo:GO_0042773c
Restrictions obo:TXPO_0003500op some obo:GO_0005739c

regulation of apoptotic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0042981
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0006915c
Sub-classes obo:GO_0043065c
obo:GO_0043066c

positive regulation of apoptotic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0043065
Super-classes obo:GO_0042981c
Restrictions obo:RO_0002213op some obo:GO_0006915c
Sub-classes obo:TXPO_0002114c
obo:TXPO_0000928c

negative regulation of apoptotic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0043066
Super-classes obo:GO_0042981c
Restrictions obo:RO_0002212op some obo:GO_0006915c
Sub-classes obo:TXPO_0002322c
obo:TXPO_0004396c
obo:TXPO_0001926c
obo:TXPO_0002100c
obo:TXPO_0002239c
obo:TXPO_0000965c
obo:TXPO_0001149c
obo:TXPO_0003786c
obo:TXPO_0001595c
obo:TXPO_0000371c

proteasome-mediated ubiquitin-dependent protein catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0043161
Super-classes obo:GO_0010498c
Sub-classes obo:TXPO_0002432c
obo:TXPO_0003770c
obo:TXPO_0004048c

organellec # Classes

URI http://purl.obolibrary.org/obo/GO_0043226
Super-classes obo:GO_0005575c
Sub-classes obo:GO_0005694c
obo:GO_0005856c
obo:GO_0005840c
obo:GO_0043227c

membrane-bounded organellec # Classes

URI http://purl.obolibrary.org/obo/GO_0043227
Super-classes obo:GO_0043226c
Sub-classes obo:GO_0005773c
obo:GO_0005634c
obo:GO_0005783c
obo:GO_0031982c
obo:GO_0005739c
obo:GO_0005794c
obo:GO_0042579c

organelle lumenc # Classes

URI http://purl.obolibrary.org/obo/GO_0043233
Super-classes obo:UBERON_0000464c
Sub-classes obo:GO_0005788c
obo:GO_0005796c

regulation of potassium ion transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0043266
Super-classes obo:GO_0051049c
Restrictions obo:RO_0002211op some obo:GO_0006813c
Sub-classes obo:GO_0043267c
obo:GO_0043268c

negative regulation of potassium ion transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0043267
Super-classes obo:GO_0043266c
Sub-classes obo:TXPO_0004084c

positive regulation of potassium ion transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0043268
Super-classes obo:GO_0043266c

anoikisc # Classes

URI http://purl.obolibrary.org/obo/GO_0043276
Super-classes obo:GO_0006915c
Sub-classes obo:TXPO_0000512c

apoptotic cell clearancec # Classes

URI http://purl.obolibrary.org/obo/GO_0043277
Super-classes obo:TXPO_0000458c

protein unfoldingc # Classes

URI http://purl.obolibrary.org/obo/GO_0043335
Super-classes obo:TXPO_0002565c
Sub-classes obo:TXPO_0002161c
obo:TXPO_0001894c

regulation of generation of precursor metabolites and energyc # Classes

URI http://purl.obolibrary.org/obo/GO_0043467
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0006091c
Sub-classes obo:TXPO_0001619c

accumulation of pigmentsc # Classes

URI http://purl.obolibrary.org/obo/GO_0043473
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:GO_0048770c
Sub-classes obo:TXPO_0000259c
obo:TXPO_0000258c
obo:TXPO_0000083c

protein kinase B signalingc # Classes

URI http://purl.obolibrary.org/obo/GO_0043491
Super-classes obo:TXPO_0000609c

protein acylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0043543
Super-classes obo:GO_0036211c
Sub-classes obo:GO_0006473c

small molecule metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0044281
Description

The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
Super-classes obo:GO_0008152c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:GO_0006520c

cell partc # Classes

URI http://purl.obolibrary.org/obo/GO_0044464
Super-classes obo:GO_0005575c
Restrictions obo:BFO_0000050op some obo:CL_0000000c
Sub-classes obo:GO_0005622c
obo:GO_0005815c
obo:GO_0005615c
obo:GO_0005576c

dendritic cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_0044565
Super-classes obo:GO_0046651c

cell cycle phase transitionc # Classes

URI http://purl.obolibrary.org/obo/GO_0044770
Super-classes obo:TXPO_0000425c
Sub-classes obo:GO_0044843c
obo:GO_0044839c

cell quiescencec # Classes

URI http://purl.obolibrary.org/obo/GO_0044838
Super-classes obo:GO_0022403c

cell cycle G2/M phase transitionc # Classes

URI http://purl.obolibrary.org/obo/GO_0044839
Super-classes obo:GO_0044770c

cell cycle G1/S phase transitionc # Classes

URI http://purl.obolibrary.org/obo/GO_0044843
Super-classes obo:GO_0044770c
Sub-classes obo:TXPO_0000669c

innate immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0045087
Super-classes obo:GO_0006955c
Sub-classes obo:GO_0002228c

regulation of innate immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0045088
Super-classes obo:GO_0050776c
Restrictions obo:RO_0002211op some obo:GO_0045087c
Sub-classes obo:TXPO_0001523c

protein palmitoleylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0045234
Super-classes obo:GO_0006497c

leukocyte activationc # Classes

URI http://purl.obolibrary.org/obo/GO_0045321
Super-classes obo:GO_0001775c
Sub-classes obo:GO_0042116c
obo:GO_0046649c

Adipocyte differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0045444
Super-classes obo:GO_0030154c
Restrictions obo:RO_0000057op some obo:CL_0000136c

myoblast differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0045445
Super-classes obo:TXPO_0002703c
Sub-classes obo:TXPO_0003757c

endothelial cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0045446
Super-classes obo:GO_0030855c

regulation of cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0045595
Super-classes obo:TXPO_0000113c
Sub-classes obo:GO_0010743c

negative regulation of gluconeogenesisc # Classes

URI http://purl.obolibrary.org/obo/GO_0045721
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006094c
Sub-classes obo:TXPO_0003926c
obo:TXPO_0004742c

negative regulation of DNA repairc # Classes

URI http://purl.obolibrary.org/obo/GO_0045738
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006281c
Sub-classes obo:TXPO_0004508c

positive regulation of cell cyclec # Classes

URI http://purl.obolibrary.org/obo/GO_0045787
Super-classes obo:GO_0051726c
obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0007049c
Sub-classes obo:TXPO_0004459c

negative regulation of endocytosisc # Classes

URI http://purl.obolibrary.org/obo/GO_0045806
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006897c
Sub-classes obo:TXPO_0002297c

negative regulation of glycolytic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0045820
Super-classes obo:TXPO_0000115c
Restrictions obo:RO_0002212op some obo:GO_0006096c
Sub-classes obo:TXPO_0000675c

positive regulation of proteolysisc # Classes

URI http://purl.obolibrary.org/obo/GO_0045862
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0006508c
Sub-classes obo:GO_1904294c

negative regulation of transcription, DNA-templatedc # Classes

URI http://purl.obolibrary.org/obo/GO_0045892
Super-classes obo:GO_0006355c
Restrictions obo:RO_0002212op some obo:GO_0006351c
Sub-classes obo:TXPO_0002218c

ATP metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046034
Super-classes obo:GO_0008152c
Restrictions obo:BFO_0000051op some obo:TXPO_0001165c
obo:BFO_0000051op some obo:GO_0006754c

aflatoxin metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046222
Super-classes obo:GO_0009404c
Sub-classes obo:TXPO_0004908c

phosphatidylethanolamine catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046338
Super-classes obo:GO_0046475c
Restrictions obo:RO_0002233op some obo:CHEBI_16038c

phosphatidylcholine metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046470
Super-classes obo:GO_0006650c
Restrictions obo:RO_0000057op some obo:CHEBI_64482c
Sub-classes obo:GO_0034638c
obo:GO_0006656c

phosphatidylglycerol metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046471
Super-classes obo:GO_0006650c
Restrictions obo:RO_0000057op some obo:CHEBI_17517c
Sub-classes obo:GO_0006655c
obo:GO_0034478c

phosphatidic acid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046473
Super-classes obo:GO_0006650c
Restrictions obo:RO_0000057op some obo:CHEBI_16337c
Sub-classes obo:GO_0006654c

glycerophospholipid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046474
Super-classes obo:GO_0006650c
obo:GO_0008654c
Restrictions obo:RO_0002234op some obo:CHEBI_37739c
Sub-classes obo:GO_0006656c
obo:GO_0006646c
obo:GO_0006661c
obo:GO_0006659c
obo:GO_0006654c
obo:GO_0006655c

glycerophospholipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046475
Super-classes obo:GO_0006650c
obo:GO_0009395c
Restrictions obo:RO_0002233op some obo:CHEBI_37739c
Sub-classes obo:GO_0006660c
obo:GO_0034638c
obo:GO_0034478c
obo:TXPO_0001620c
obo:GO_0031161c
obo:GO_0046338c

phosphatidylinositol metabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046488
Super-classes obo:GO_0006650c
Restrictions obo:RO_0000057op some obo:CHEBI_28874c
Sub-classes obo:GO_0031161c
obo:GO_0006661c

ceramide biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046513
Super-classes obo:GO_0008610c

ceramide catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046514
Super-classes obo:TXPO_0000071c
Restrictions obo:RO_0002233op some obo:CHEBI_17761c

drug exportc # Classes

URI http://purl.obolibrary.org/obo/GO_0046618
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some (obo:BFO_0000002c and ub744bL14542C17c)

lymphocyte activationc # Classes

URI http://purl.obolibrary.org/obo/GO_0046649
Super-classes obo:GO_0045321c
Sub-classes obo:GO_0042110c
obo:GO_0030101c

lymphocyte proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_0046651
Super-classes obo:GO_0008283c
Restrictions obo:RO_0002234op some (obo:CL_0000542c and ub744bL14568C17c)
Sub-classes obo:GO_0042100c
obo:GO_0042098c
obo:GO_0044565c
obo:GO_0001787c

negative regulation of insulin secretionc # Classes

URI http://purl.obolibrary.org/obo/GO_0046676
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0030073c
Sub-classes obo:TXPO_0001311c

protein autophosphorylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0046777
Super-classes obo:GO_0016310c
Sub-classes obo:TXPO_0000742c
obo:TXPO_0002597c

positive regulation of lipid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046889
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0008610c
Sub-classes obo:TXPO_0001153c

ketone body biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0046951
Super-classes obo:TXPO_0000019c
Restrictions obo:RO_0002234op some obo:CHEBI_73693c
Sub-classes obo:TXPO_0004374c

HGFR signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0048012
Super-classes obo:TXPO_0000609c

Golgi vesicle transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0048193
Super-classes obo:GO_0006810c

pigment granulec # Classes

URI http://purl.obolibrary.org/obo/GO_0048770
Super-classes obo:GO_0031982c
Sub-classes obo:TXPO_0003820c
obo:TXPO_0003821c

chemical homeostasisc # Classes

URI http://purl.obolibrary.org/obo/GO_0048878
Super-classes obo:GO_0042592c

cytokine secretionc # Classes

URI http://purl.obolibrary.org/obo/GO_0050663
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some (obo:BFO_0000002c and ub744bL14648C17c)
Sub-classes obo:TXPO_0003745c

regulation of immune responsec # Classes

URI http://purl.obolibrary.org/obo/GO_0050776
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0006955c
Sub-classes obo:GO_0045088c

response to stimulusc # Classes

URI http://purl.obolibrary.org/obo/GO_0050896
Super-classes obo:TXPO_0001984c
Sub-classes obo:GO_0009719c
obo:GO_0006950c
obo:GO_0009605c
obo:GO_0006974c
obo:GO_0006955c

leukocyte migrationc # Classes

URI http://purl.obolibrary.org/obo/GO_0050900
Super-classes obo:GO_0016477c
Sub-classes obo:GO_0030595c
obo:TXPO_0005020c
obo:GO_1905517c
obo:TXPO_0004315c
obo:TXPO_0004313c

positive regulation of lipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0050996
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0016042c
Sub-classes obo:TXPO_0001174c

regulation of transport (biology)c # Classes

URI http://purl.obolibrary.org/obo/GO_0051049
Super-classes obo:TXPO_0003636c
Restrictions obo:RO_0002211op some obo:GO_0006810c
Sub-classes obo:TXPO_0003637c
obo:GO_0043266c

negative regulation of lipid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0051055
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0008610c
Sub-classes obo:TXPO_0000182c
obo:TXPO_0003956c

nuclear exportc # Classes

URI http://purl.obolibrary.org/obo/GO_0051168
Super-classes obo:GO_0051169c
Restrictions obo:RO_0002338op some obo:GO_0005634c

nuclear transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0051169
Super-classes obo:GO_0006810c
Restrictions obo:BFO_0000066op some obo:GO_0005634c
Sub-classes obo:TXPO_0000053c
obo:GO_0006913c
obo:TXPO_0003917c
obo:TXPO_0002980c
obo:TXPO_0002494c
obo:GO_0051170c
obo:GO_0051168c

import into nucleusc # Classes

URI http://purl.obolibrary.org/obo/GO_0051170
Super-classes obo:GO_0051169c
Restrictions obo:RO_0002339op some obo:GO_0005634c

sequestering of calcium ionc # Classes

URI http://purl.obolibrary.org/obo/GO_0051208
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_39124c
Sub-classes obo:TXPO_0003554c

protein polymerizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0051258
Super-classes obo:GO_0006461c
Sub-classes obo:TXPO_0003641c

chromosome organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0051276
Super-classes obo:TXPO_0002566c

cell divisionc # Classes

URI http://purl.obolibrary.org/obo/GO_0051301
Super-classes obo:TXPO_0002576c
Restrictions obo:RO_0002233op some obo:CL_0000000c
Sub-classes obo:TXPO_0001570c
obo:TXPO_0003298c
obo:TXPO_0003793c

G1 phasec # Classes

URI http://purl.obolibrary.org/obo/GO_0051318
Super-classes obo:GO_0022403c

G2 phasec # Classes

URI http://purl.obolibrary.org/obo/GO_0051319
Description

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
Super-classes obo:GO_0022403c

S phasec # Classes

URI http://purl.obolibrary.org/obo/GO_0051320
Super-classes obo:GO_0022403c

regulation of cell cyclec # Classes

URI http://purl.obolibrary.org/obo/GO_0051726
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:GO_0007049c
Sub-classes obo:TXPO_0003231c
obo:TXPO_0001489c
obo:TXPO_0000374c
obo:GO_0045787c
obo:TXPO_0001580c
obo:TXPO_0002376c
obo:TXPO_0003296c
obo:TXPO_0000954c

positive regulation of cell divisionc # Classes

URI http://purl.obolibrary.org/obo/GO_0051781
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0051301c
Sub-classes obo:TXPO_0003795c
obo:TXPO_0004403c
obo:TXPO_0004897c

negative regulation of protein kinase B signalingc # Classes

URI http://purl.obolibrary.org/obo/GO_0051898
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:TXPO_0001494c
obo:RO_0002212op some obo:GO_0043491c
Sub-classes obo:TXPO_0002103c
obo:TXPO_0004416c
obo:TXPO_0000781c

xenobiotic glucuronidationc # Classes

URI http://purl.obolibrary.org/obo/GO_0052697
Super-classes obo:GO_0019585c
Sub-classes obo:TXPO_0001599c

recycling endosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0055037
Super-classes obo:GO_0005768c

transmembrane transportc # Classes

URI http://purl.obolibrary.org/obo/GO_0055085
Description

Transmembrane transport requires transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.
Super-classes obo:GO_0006810c
Restrictions obo:BFO_0000066op some obo:TXPO_0000895c

maintaining phospholipid homeostasisc # Classes

URI http://purl.obolibrary.org/obo/GO_0055091
Super-classes obo:GO_0042592c
Sub-classes obo:TXPO_0001683c
obo:TXPO_0002273c

oxidation-reduction processc # Classes

URI http://purl.obolibrary.org/obo/GO_0055114
Super-classes obo:GO_0008152c
Sub-classes obo:TXPO_0002377c
obo:GO_0022900c
obo:GO_0034440c

Transdifferentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0060290
Super-classes obo:GO_0030154c

positive regulation of phospholipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0060697
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0009395c
Sub-classes obo:TXPO_0002255c

membrane organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0061024
Super-classes obo:GO_0071840c
Restrictions obo:BFO_0000066op some obo:GO_0005886c
Sub-classes obo:GO_0090158c

inflammasome complexc # Classes

URI http://purl.obolibrary.org/obo/GO_0061702
Super-classes obo:TXPO_0002107c

engulfment of target by autophagosomec # Classes

URI http://purl.obolibrary.org/obo/GO_0061736
Super-classes obo:GO_0010324c

lysophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_0062093
Super-classes obo:GO_0006914c
Restrictions obo:BFO_0000066op some obo:GO_0005776c
obo:RO_0002233op some obo:GO_0005764c
Sub-classes obo:TXPO_0001485c

protein-containing complex assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0065003
Super-classes obo:TXPO_0003815c
Restrictions obo:RO_0002233op some obo:CHEBI_36080c
Sub-classes obo:TXPO_0001254c
obo:GO_0006461c
obo:GO_0033108c
obo:GO_0065005c

protein-lipid complex assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0065005
Super-classes obo:GO_0065003c
Restrictions obo:RO_0002233op some obo:CHEBI_18059c
Sub-classes obo:GO_0034379c

glycosylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0070085
Super-classes obo:GO_0008152c
Sub-classes obo:GO_0006486c

interleukin-6-mediated signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0070102
Super-classes obo:TXPO_0000609c

necrosisc # Classes

URI http://purl.obolibrary.org/obo/GO_0070265
Description

Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
Super-classes obo:GO_0008219c
Sub-classes obo:TXPO_0000539c
obo:TXPO_0004342c
obo:TXPO_0003495c
obo:TXPO_0002200c
obo:TXPO_0003852c
obo:TXPO_0003779c
obo:TXPO_0002387c
obo:TXPO_0002669c
obo:TXPO_0004591c

pyroptosisc # Classes

URI http://purl.obolibrary.org/obo/GO_0070269
Super-classes obo:GO_0008219c
Sub-classes obo:TXPO_0002144c

phosphatidic acid bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_0070300
Super-classes obo:GO_0005543c

IL-1 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0070498
Super-classes obo:TXPO_0000609c

protein modification by small protein removalc # Classes

URI http://purl.obolibrary.org/obo/GO_0070646
Super-classes obo:GO_0070647c
Sub-classes obo:GO_0016579c

protein modification by small protein conjugation or removalc # Classes

URI http://purl.obolibrary.org/obo/GO_0070647
Super-classes obo:GO_0036211c
Sub-classes obo:TXPO_0004107c
obo:GO_0070646c

demethylationc # Classes

URI http://purl.obolibrary.org/obo/GO_0070988
Super-classes obo:GO_0008152c
Sub-classes obo:TXPO_0004672c

positive regulation of phospholipid biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0071073
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0008654c
Sub-classes obo:TXPO_0003400c
obo:TXPO_0001710c

transforming growth factor beta productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0071604
Super-classes obo:GO_0001816c

chemokine (C-C motif) ligand 4 productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0071606
Super-classes obo:GO_0032602c

chemokine (C-C motif) ligand 1 productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0071610
Super-classes obo:GO_0032602c

tumor necrosis factor superfamily cytokine productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0071706
Super-classes obo:GO_0001816c
Sub-classes obo:GO_0032640c

endoplasmic reticulum-associated degradationc # Classes

URI http://purl.obolibrary.org/obo/GO_0071712
Super-classes obo:GO_0036503c
Sub-classes obo:TXPO_0002204c

cellular component organization or biogenesisc # Classes

URI http://purl.obolibrary.org/obo/GO_0071840
Super-classes obo:TXPO_0000134c
Sub-classes obo:GO_0001845c
obo:GO_0030032c
obo:GO_0007033c
obo:GO_0032060c
obo:GO_0007028c
obo:GO_0006996c
obo:GO_0061024c

DNA biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_0071897
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_16991c

signal transduction by p53 class mediatorc # Classes

URI http://purl.obolibrary.org/obo/GO_0072331
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0000237c

hepatocyte proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_0072574
Super-classes obo:GO_0008283c
Restrictions obo:RO_0002234op some (obo:CL_0000182c and ub744bL15099C17c)
Sub-classes obo:TXPO_0000970c
obo:TXPO_0000217c

foam cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/GO_0090077
Super-classes obo:GO_0030154c
Sub-classes obo:GO_0010742c

endosome to lysosome transport of low-density lipoprotein particlec # Classes

URI http://purl.obolibrary.org/obo/GO_0090117
Super-classes obo:GO_0030301c

endoplasmic reticulum membrane organizationc # Classes

URI http://purl.obolibrary.org/obo/GO_0090158
Super-classes obo:GO_0061024c
Sub-classes obo:TXPO_0001615c

cellular senescencec # Classes

URI http://purl.obolibrary.org/obo/GO_0090398
Super-classes obo:TXPO_0000392c
Sub-classes obo:TXPO_0001006c

intrinsic apoptotic signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/GO_0097193
Super-classes obo:TXPO_0000609c
Sub-classes obo:TXPO_0003111c

apoptosome assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_0097314
Super-classes obo:GO_0006461c
Sub-classes obo:TXPO_0003737c
obo:TXPO_0003110c

chemokine (C-X-C motif) ligand 12 productionc # Classes

URI http://purl.obolibrary.org/obo/GO_0097390
Super-classes obo:GO_0032602c

feroptosisc # Classes

URI http://purl.obolibrary.org/obo/GO_0097707
Super-classes obo:GO_0008219c

detoxificationc # Classes

URI http://purl.obolibrary.org/obo/GO_0098754
Super-classes obo:TXPO_0000458c
Sub-classes obo:GO_1990748c

inner mitochondrial membrane protein complexc # Classes

URI http://purl.obolibrary.org/obo/GO_0098800
Super-classes obo:TXPO_0002107c
Sub-classes obo:TXPO_0004329c
obo:GO_0005747c
obo:GO_0005751c

cellular oxidant detoxificationc # Classes

URI http://purl.obolibrary.org/obo/GO_0098869
Super-classes obo:GO_1990748c

plasma membrane invaginationc # Classes

URI http://purl.obolibrary.org/obo/GO_0099024
Super-classes obo:GO_0010324c

positive regulation of cellular response to oxidative stressc # Classes

URI http://purl.obolibrary.org/obo/GO_1900409
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0006979c
obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:TXPO_0002746c

regulation of mitophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_1901524
Super-classes obo:GO_0010506c
Restrictions obo:RO_0002211op some obo:GO_0000423c
Sub-classes obo:TXPO_0004977c
obo:GO_1901526c

positive regulation of mitophagyc # Classes

URI http://purl.obolibrary.org/obo/GO_1901526
Super-classes obo:GO_1901524c
Restrictions obo:RO_0002213op some obo:GO_0000423c
Sub-classes obo:TXPO_0004443c

fatty acid derivative bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_1901567
Super-classes obo:GO_0005488c
Restrictions obo:RO_0002233op some obo:CHEBI_61697c
Sub-classes obo:GO_0000062c

phosphatidylglycerol bindingc # Classes

URI http://purl.obolibrary.org/obo/GO_1901611
Super-classes obo:GO_0005543c

negative regulation of p53 signalingc # Classes

URI http://purl.obolibrary.org/obo/GO_1901797
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:GO_0007173c
obo:RO_0002212op some obo:TXPO_0000001c
Sub-classes obo:TXPO_0004683c
obo:TXPO_0000964c

negative regulation of proteasomal protein catabolic processc # Classes

URI http://purl.obolibrary.org/obo/GO_1901799
Super-classes obo:GO_0042177c
Restrictions obo:RO_0002212op some obo:GO_0010498c
Sub-classes obo:TXPO_0002441c
obo:TXPO_0003017c

negative regulation of cell junction assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_1901889
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0034329c
Sub-classes obo:GO_1903597c
obo:TXPO_0000955c

cell cycle DNA replication initiationc # Classes

URI http://purl.obolibrary.org/obo/GO_1902292
Super-classes obo:TXPO_0001984c
Sub-classes obo:TXPO_0000962c

negative regulation of nuclear cell cycle DNA replicationc # Classes

URI http://purl.obolibrary.org/obo/GO_1902576
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006260c

proton transmembrane transportc # Classes

URI http://purl.obolibrary.org/obo/GO_1902600
Super-classes obo:GO_0006811c
Sub-classes obo:GO_0015990c

negative regulation of mitochondrial electron transport, NADH to ubiquinonec # Classes

URI http://purl.obolibrary.org/obo/GO_1902957
Super-classes obo:TXPO_0002342c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:RO_0002212op some obo:GO_0006120c
Sub-classes obo:TXPO_0004109c

reactive oxygen species biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_1903409
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_26523c
Sub-classes obo:TXPO_0000948c
obo:TXPO_0001086c
obo:TXPO_0003173c
obo:TXPO_0003850c
obo:TXPO_0001990c

negative regulation of ROS formationc # Classes

URI http://purl.obolibrary.org/obo/GO_1903427
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_1903409c
Sub-classes obo:TXPO_0005032c

negative regulation of gap junction assemblyc # Classes

URI http://purl.obolibrary.org/obo/GO_1903597
Super-classes obo:GO_1901889c
Restrictions obo:RO_0002212op some obo:GO_0016264c
Sub-classes obo:TXPO_0003790c

positive regulation of glutathione biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/GO_1903788
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0006750c
Sub-classes obo:TXPO_0004098c

positive regulation of ERADc # Classes

URI http://purl.obolibrary.org/obo/GO_1904294
Super-classes obo:GO_0045862c
Restrictions obo:RO_0002213op some obo:GO_0036503c
Sub-classes obo:TXPO_0000386c

positive regulation of protein refoldingc # Classes

URI http://purl.obolibrary.org/obo/GO_1904592
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:GO_0042026c
Sub-classes obo:TXPO_0000413c

macrophage migrationc # Classes

URI http://purl.obolibrary.org/obo/GO_1905517
Super-classes obo:GO_0050900c
Sub-classes obo:TXPO_0000764c
obo:TXPO_0004113c
obo:TXPO_0004275c
obo:TXPO_0004978c

cellular detoxificationc # Classes

URI http://purl.obolibrary.org/obo/GO_1990748
Super-classes obo:GO_0098754c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:GO_0098869c

hepatic stellate cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/GO_1990922
Super-classes obo:GO_0008283c
Restrictions obo:RO_0002233op some obo:CL_0000632c
obo:RO_0002234op some (obo:CL_0000632c and ub744bL15404C17c)
Sub-classes obo:TXPO_0003755c

negative regulation of cellular senescencec # Classes

URI http://purl.obolibrary.org/obo/GO_2000773
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0090398c
Sub-classes obo:TXPO_0004477c
obo:TXPO_0001052c

Activation, translocation and oligomerization of BAXc # Classes

URI http://purl.obolibrary.org/obo/HINO_0016226
Description

As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000)
Super-classes obo:TXPO_0003222c
Sub-classes obo:TXPO_0003235c

Activation and oligomerization of BAK proteinc # Classes

URI http://purl.obolibrary.org/obo/HINO_0016227
Description

tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux.
Super-classes obo:TXPO_0003222c
Sub-classes obo:TXPO_0003163c

Activation of BH3-only proteinsc # Classes

URI http://purl.obolibrary.org/obo/HINO_0016241
Super-classes obo:TXPO_0003222c

amino acid conjugationc # Classes

URI http://purl.obolibrary.org/obo/HINO_0016364
Super-classes obo:GO_0006520c

Glutathione synthesis and recyclingc # Classes

URI http://purl.obolibrary.org/obo/HINO_0016374
Super-classes obo:TXPO_0000610c

Translocation of NF-kappaB from the cytosol to the nucleusc # Classes

URI http://purl.obolibrary.org/obo/HINO_0017769
Super-classes obo:TXPO_0002494c
Restrictions obo:RO_0002234op some obo:TXPO_0002769c
Sub-classes obo:TXPO_0002779c

Phenotypic abnormalityc # Classes

URI http://purl.obolibrary.org/obo/HP_0000118
Super-classes obo:BFO_0000019c
Sub-classes obo:HP_0000969c

edemac # Classes

URI http://purl.obolibrary.org/obo/HP_0000969
Super-classes obo:HP_0000118c

Hyperglycemiac # Classes

URI http://purl.obolibrary.org/obo/HP_0003074
Super-classes obo:PATO_0001162c

information content entityc # Classes

URI http://purl.obolibrary.org/obo/IAO_0000030
Super-classes obo:BFO_0000031c
Sub-classes obo:TXPO_0000614c

measurement datumc # Classes

URI http://purl.obolibrary.org/obo/IAO_0000109
Super-classes obo:TXPO_0000614c

Wntc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000003
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
Sub-classes obo:IMR_0100773c
obo:IMR_0100768c
obo:IMR_0100781c
obo:IMR_0100775c
obo:IMR_0100767c
obo:IMR_0100765c
obo:IMR_0100770c
obo:IMR_0100777c
obo:IMR_0100772c
obo:IMR_0100766c
obo:IMR_0100771c
obo:IMR_0100779c
obo:IMR_0100778c
obo:IMR_0100783c
obo:IMR_0100769c
obo:IMR_0100774c
obo:IMR_0100776c
obo:IMR_0100782c
obo:IMR_0100780c

hedgehogc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000004
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
Sub-classes obo:IMR_0000005c
obo:IMR_0100739c
obo:IMR_0100738c

SHH (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000005
Super-classes obo:IMR_0000004c
Sub-classes obo:TXPO_0004632c

Interleukinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000007
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
obo:TXPO_0002260op some obo:IMR_0000007c
Sub-classes obo:IMR_0000599c
obo:TXPO_0004103c
obo:IMR_0000590c
obo:IMR_0002718c
obo:IMR_0000588c
obo:IMR_0000595c
obo:IMR_0000587c
obo:IMR_0000009c
obo:IMR_0000589c
obo:TXPO_1000200c
obo:TXPO_1000201c
obo:IMR_0000601c
obo:IMR_0000013c
obo:IMR_0000010c
obo:IMR_0000586c
obo:IMR_0002716c
obo:IMR_0000012c
obo:IMR_0000011c
obo:IMR_0000585c
obo:IMR_0000598c
obo:IMR_0000596c
obo:IMR_0000008c
obo:IMR_0000597c

IL-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000008
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000009
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000010
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
Sub-classes obo:IMR_0000019c
obo:TXPO_0004224c
obo:TXPO_0003172c
obo:TXPO_0004660c
obo:TXPO_0004319c
obo:TXPO_0003775c
obo:TXPO_0003037c
obo:TXPO_0004385c
obo:TXPO_0004654c

IL-1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000011
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
Sub-classes obo:TXPO_0003774c
obo:IMR_0100855c
obo:IMR_0100854c

IL-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000012
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000013
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

TPOc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000015
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000155c

EPOc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000016
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
obo:RO_0000087op some obo:TXPO_0000155c

G-CSFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000017
Description

related molecular function GO:0005130
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

GM-CSFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000018
Description

relate molecular function GO:0005129
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

LIFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000019
Super-classes obo:IMR_0000010c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

SCFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000020
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
obo:RO_0000087op some obo:TXPO_0000155c

TNF superfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000021
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
Sub-classes obo:IMR_0000026c
obo:IMR_0000025c
obo:IMR_0000022c
obo:IMR_0001200c
obo:IMR_0000023c

FasLc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000022
Super-classes obo:IMR_0000021c

CD40Lc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000023
Super-classes obo:IMR_0000021c

TNF alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000025
Super-classes obo:IMR_0000021c

LT alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000026
Super-classes obo:IMR_0000021c

Interferonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000027
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
Sub-classes obo:IMR_0000028c
obo:IMR_0000029c

IFN type Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0000028
Super-classes obo:IMR_0000027c
Sub-classes obo:IMR_0100386c
obo:IMR_0100388c
obo:IMR_0100389c
obo:IMR_0100387c

IFN type IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000029
Super-classes obo:IMR_0000027c
Sub-classes obo:IMR_0100390c

VEGF (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000031
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0002395c
obo:RO_0000087op some obo:TXPO_0000624c
Sub-classes obo:TXPO_0004857c
obo:TXPO_0004858c

PDGFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000032
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
obo:RO_0000087op some obo:TXPO_0002395c
Sub-classes obo:IMR_0100550c
obo:TXPO_0003752c
obo:IMR_0100549c

HGFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000033
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
obo:RO_0000087op some obo:TXPO_0002395c

NGF familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000034
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
obo:RO_0000087op some obo:TXPO_0002395c
Sub-classes obo:IMR_0100407c
obo:IMR_0100409c
obo:IMR_0100410c
obo:IMR_0100408c

type I cytokeratinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000035
Super-classes obo:IMR_0000202c
Sub-classes obo:IMR_0000459c
obo:IMR_0000458c
obo:IMR_0000362c
obo:IMR_0000471c
obo:IMR_0000366c
obo:IMR_0000365c
obo:IMR_0000352c
obo:IMR_0000467c
obo:IMR_0000363c
obo:IMR_0000364c
obo:IMR_0000466c
obo:IMR_0000367c
obo:IMR_0000413c

TGF-beta superfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000036
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
obo:RO_0000087op some obo:TXPO_0002395c
Sub-classes obo:IMR_0000046c
obo:IMR_0000040c
obo:IMR_0000041c
obo:IMR_0000039c
obo:IMR_0000037c

inhibinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000037
Super-classes obo:IMR_0000036c

activinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000039
Super-classes obo:IMR_0000036c

BMP familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000040
Super-classes obo:IMR_0000036c
Sub-classes obo:IMR_0001437c
obo:IMR_0001434c
obo:IMR_0003083c
obo:IMR_0001426c
obo:IMR_0001436c
obo:IMR_0001435c
obo:IMR_0001427c
obo:IMR_0003077c
obo:IMR_0003084c
obo:IMR_0003085c
obo:IMR_0003080c
obo:IMR_0003073c

TGF-beta familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000041
Super-classes obo:IMR_0000036c
Sub-classes obo:IMR_0000042c
obo:IMR_0000043c
obo:IMR_0000044c

TGF-beta1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000042
Super-classes obo:IMR_0000041c
Sub-classes obo:TXPO_0003751c
obo:TXPO_0003892c
obo:TXPO_0003893c
obo:TXPO_0004827c
obo:TXPO_0003897c
obo:TXPO_0003895c

TGF-beta2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000043
Super-classes obo:IMR_0000041c

TGF-beta3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000044
Super-classes obo:IMR_0000041c

GDNFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000045
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0002395c
obo:RO_0000087op some obo:TXPO_0000624c

Nodal familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000046
Super-classes obo:IMR_0000036c

EGF familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000047
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0002395c
obo:RO_0000087op some obo:TXPO_0000624c
Sub-classes obo:IMR_0100279c
obo:IMR_0100275c
obo:IMR_0100274c
obo:IMR_0000048c
obo:IMR_0100277c
obo:IMR_0100278c
obo:IMR_0100276c

neuregulinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000048
Super-classes obo:IMR_0000047c
Sub-classes obo:IMR_0000616c
obo:IMR_0000615c
obo:IMR_0000614c
obo:IMR_0000617c

FGFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000049
Super-classes obo:TXPO_0001382c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
obo:RO_0000087op some obo:TXPO_0002395c
Sub-classes obo:IMR_0100562c
obo:IMR_0100572c
obo:IMR_0100568c
obo:IMR_0100565c
obo:IMR_0100560c
obo:IMR_0100561c
obo:IMR_0100555c
obo:IMR_0100569c
obo:IMR_0100558c
obo:IMR_0100567c
obo:IMR_0100551c
obo:IMR_0100557c
obo:IMR_0100563c
obo:IMR_0100573c
obo:IMR_0100566c
obo:IMR_0100556c
obo:IMR_0100570c
obo:IMR_0100559c
obo:IMR_0100554c
obo:IMR_0100571c
obo:IMR_0100552c
obo:IMR_0100553c
obo:IMR_0100564c

type II cytokeratinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000050
Super-classes obo:IMR_0000202c
Sub-classes obo:IMR_0000164c
obo:IMR_0000087c
obo:IMR_0000469c
obo:IMR_0000053c
obo:IMR_0000146c
obo:IMR_0000162c
obo:IMR_0000163c

leptinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000051
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c

insulinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000052
Super-classes obo:IMR_0002835c
Restrictions obo:TXPO_0002260op some obo:IMR_0002835c
Sub-classes obo:TXPO_0004090c
obo:TXPO_0001109c

cytokeratin 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000053
Super-classes obo:IMR_0000050c

TNFR familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000056
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0001202c
obo:IMR_0000058c
obo:IMR_0100674c
obo:IMR_0000057c
obo:IMR_0001201c

CD40c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000057
Super-classes obo:IMR_0000056c

FasRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000058
Super-classes obo:IMR_0000056c

TNFR1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000060
Super-classes obo:IMR_0100674c

TNFR2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000061
Super-classes obo:IMR_0100674c

PDGF receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000068
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000823c
Sub-classes obo:IMR_0000070c
obo:IMR_0000069c

alpha PDGF receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000069
Super-classes obo:IMR_0000068c

beta PDGF receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000070
Super-classes obo:IMR_0000068c

insulin receptor familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000075
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000823c
Sub-classes obo:IMR_0000078c
obo:IMR_0100677c
obo:IMR_0000077c
obo:IMR_0000076c

ALKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000076
Super-classes obo:IMR_0000075c

LTKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000077
Super-classes obo:IMR_0000075c

insulin receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000078
Super-classes obo:IMR_0000075c

FGFR familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000080
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000823c
Sub-classes obo:IMR_0002055c
obo:IMR_0002058c
obo:IMR_0002056c
obo:IMR_0002057c

EGFR (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000081
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000823c
Sub-classes obo:TXPO_0004527c
obo:TXPO_0001798c
obo:TXPO_0003912c
obo:TXPO_0004528c

IP3 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000084
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003161c
obo:RO_0000087op some obo:TXPO_0002628c

TRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000086
Super-classes obo:TXPO_0001509c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c
Sub-classes obo:IMR_0100419c
obo:IMR_0100421c
obo:IMR_0100420c
obo:IMR_0100418c

cytokeratin 3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000087
Super-classes obo:IMR_0000050c

Estrogen receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000088
Super-classes obo:TXPO_0001509c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c

PPARc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000089
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c
Sub-classes obo:TXPO_0000159c
obo:TXPO_0000162c

RARc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000090
Super-classes obo:TXPO_0001509c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c

TGF-beta receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000092
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0002154c
Sub-classes obo:IMR_0000094c
obo:IMR_0000093c

TGF-beta receptor type Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0000093
Super-classes obo:IMR_0000092c

TGF-beta receptor type IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000094
Super-classes obo:IMR_0000092c

interleukin receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000096
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003331c
Sub-classes obo:IMR_0000113c
obo:IMR_0000120c
obo:IMR_0000107c
obo:IMR_0000611c
obo:IMR_0000097c
obo:IMR_0000608c
obo:IMR_0000101c
obo:IMR_0000123c
obo:IMR_0000602c
obo:IMR_0002717c
obo:IMR_0000115c
obo:IMR_0000117c
obo:IMR_0000111c
obo:IMR_0000104c
obo:IMR_0000600c
obo:IMR_0000109c

IL-2 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000097
Super-classes obo:IMR_0000096c

IL-5 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000101
Super-classes obo:IMR_0000096c

IL-6 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000104
Super-classes obo:IMR_0000096c

IL-4 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000107
Super-classes obo:IMR_0000096c

IL-3 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000109
Super-classes obo:IMR_0000096c

IL-7 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000111
Super-classes obo:IMR_0000096c

IL-9 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000113
Super-classes obo:IMR_0000096c

IL-13 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000115
Super-classes obo:IMR_0000096c

IL-15 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000117
Super-classes obo:IMR_0000096c

IL-1 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000120
Super-classes obo:IMR_0000096c
Sub-classes obo:IMR_0000594c
obo:IMR_0000593c

IL-18 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000123
Super-classes obo:IMR_0000096c

TLRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000124
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003441c
Sub-classes obo:IMR_0001455c
obo:IMR_0001449c
obo:IMR_0001461c
obo:IMR_0001450c
obo:IMR_0001440c
obo:IMR_0001452c
obo:IMR_0001451c
obo:IMR_0001464c
obo:IMR_0001458c

leptin receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000125
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003331c

IFNRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000134
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003331c
Sub-classes obo:IMR_0000135c
obo:IMR_0000136c

IFNR type Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0000135
Super-classes obo:IMR_0000134c
Sub-classes obo:IMR_0100392c
obo:IMR_0100391c

IFNR type IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000136
Super-classes obo:IMR_0000134c
Sub-classes obo:IMR_0100323c
obo:IMR_0100324c

MHC familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000142
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003691c
Sub-classes obo:IMR_0002516c
obo:IMR_0000143c
obo:IMR_0002515c
obo:IMR_0000144c

MHC class I moleculec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000143
Super-classes obo:IMR_0000142c

MHC class II moleculec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000144
Super-classes obo:IMR_0000142c

cytokeratin 4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000146
Super-classes obo:IMR_0000050c

TCR familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000151
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0100351c
obo:IMR_0002394c
obo:IMR_0002395c
obo:IMR_0100350c

BCRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000153
Super-classes obo:CHEBI_25367c

FcRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000156
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0000160c
obo:IMR_0000158c
obo:IMR_0000157c
obo:IMR_0000159c

FcepsilonRIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000157
Super-classes obo:IMR_0000156c

FcgammaRIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000158
Super-classes obo:IMR_0000156c

FcgammaRIIIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000159
Super-classes obo:IMR_0000156c

FcgammaRIIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000160
Super-classes obo:IMR_0000156c

cytokeratin 5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000162
Super-classes obo:IMR_0000050c

cytokeratin 7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000163
Super-classes obo:IMR_0000050c

cytokeratin 8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000164
Super-classes obo:IMR_0000050c

cytokeratin 6Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000165
Super-classes obo:IMR_0000469c

cadherinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000167
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003688c
Sub-classes obo:IMR_0000568c
obo:IMR_0000171c
obo:IMR_0000170c
obo:IMR_0000569c
obo:IMR_0000168c
obo:IMR_0000169c

E-cadherinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000168
Super-classes obo:IMR_0000167c
Sub-classes obo:TXPO_0005074c

N-cadherinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000169
Super-classes obo:IMR_0000167c

R-cadherinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000170
Super-classes obo:IMR_0000167c

VE-cadherinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000171
Super-classes obo:IMR_0000167c

integrinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000172
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003688c
Sub-classes obo:IMR_0000173c
obo:IMR_0000174c

Integrin alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000173
Super-classes obo:IMR_0000172c
Sub-classes obo:IMR_0000628c
obo:IMR_0000634c
obo:IMR_0000626c
obo:IMR_0000627c
obo:IMR_0000633c
obo:IMR_0000631c
obo:IMR_0000632c
obo:IMR_0000638c
obo:IMR_0000623c
obo:IMR_0000639c
obo:IMR_0000636c
obo:IMR_0000630c
obo:IMR_0000640c
obo:IMR_0000624c
obo:IMR_0000625c
obo:IMR_0000635c
obo:IMR_0000637c
obo:IMR_0000629c

Integrin betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000174
Super-classes obo:IMR_0000172c
Sub-classes obo:IMR_0000645c
obo:IMR_0000644c
obo:IMR_0000646c
obo:IMR_0000642c
obo:IMR_0000647c
obo:IMR_0000643c
obo:IMR_0000641c
obo:IMR_0000648c

alpha-cateninc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000176
Super-classes obo:TXPO_0003158c
Restrictions obo:RO_0000087op some obo:TXPO_0003688c

beta-cateninc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000177
Description

named 'beta-catenin family' formerly.
Super-classes obo:TXPO_0003158c
Restrictions obo:RO_0000087op some obo:TXPO_0003688c
obo:RO_0000087op some obo:TXPO_0000330c

ICAMc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000178
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003688c
Sub-classes obo:IMR_0000621c
obo:IMR_0000618c
obo:IMR_0000622c
obo:IMR_0000619c
obo:IMR_0000620c

N-CAMc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000180
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003688c

paxillinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000187
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000188c
obo:RO_0000087op some obo:TXPO_0003657c

actin cytoskeleton proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000188
Description

related cellular component GO:0015629
Super-classes obo:TXPO_0003689c

alpha-actininc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000189
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000188c
Sub-classes obo:IMR_0000485c
obo:IMR_0000483c
obo:IMR_0000479c
obo:IMR_0000484c

actinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000190
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003692c
Sub-classes obo:IMR_0000488c
obo:IMR_0000486c
obo:IMR_0000490c

myosinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000191
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000188c
obo:RO_0000087op some obo:TXPO_0003690c

tropomyosinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000192
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000188c

troponinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000193
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000188c

kinesinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000199
Super-classes obo:IMR_0100192c

dyneinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000200
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000186c
obo:RO_0000087op some obo:TXPO_0003690c
Sub-classes obo:IMR_0001209c
obo:IMR_0001213c

keratinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000202
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003693c
Sub-classes obo:IMR_0000050c
obo:IMR_0000035c

neurofilament proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000203
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003693c
Sub-classes obo:IMR_0000474c
obo:IMR_0000475c
obo:IMR_0000472c

dystrophinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000204
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003689c

APCc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000205
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003721c
obo:RO_0000087op some obo:TXPO_0003689c

ankyrinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000206
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003689c

cytokeratin 6Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000208
Super-classes obo:IMR_0000469c

Src familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000211
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001054c
Sub-classes obo:IMR_0100353c
obo:IMR_0100352c
obo:IMR_0100575c

Cskc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000212
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001054c

JAKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000213
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001054c
Sub-classes obo:IMR_0100319c
obo:IMR_0100321c
obo:IMR_0100322c
obo:IMR_0100320c

Fak/Pyk2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000217
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001054c
Sub-classes obo:IMR_0000219c
obo:IMR_0000218c

Fakc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000218
Super-classes obo:IMR_0000217c

Pyk2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000219
Super-classes obo:IMR_0000217c

ZAP-70/Sykc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000220
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001054c
Sub-classes obo:IMR_0000222c
obo:IMR_0000221c

ZAP-70c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000221
Super-classes obo:IMR_0000220c

Sykc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000222
Super-classes obo:IMR_0000220c

MAPKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000224
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0000226c
obo:IMR_0000227c
obo:IMR_0000225c
obo:IMR_0100216c

JNK/SAPKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000225
Super-classes obo:IMR_0000224c
Sub-classes obo:TXPO_0001813c
obo:IMR_0000684c
obo:TXPO_0004230c
obo:IMR_0000685c
obo:IMR_0000683c
obo:TXPO_0002298c

p38c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000226
Super-classes obo:IMR_0000224c
Sub-classes obo:IMR_0000686c
obo:IMR_0000689c
obo:TXPO_0004292c
obo:IMR_0000688c
obo:IMR_0000687c

ERK1/2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000227
Super-classes obo:IMR_0000224c
Sub-classes obo:IMR_0100448c
obo:IMR_0100449c

MAPKKKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000229
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100218c
obo:IMR_0000238c
obo:IMR_0000231c
obo:IMR_0100221c
obo:IMR_0000234c
obo:IMR_0000233c
obo:IMR_0000239c
obo:IMR_0100219c
obo:IMR_0000230c
obo:IMR_0000242c
obo:IMR_0000232c

mosc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000230
Super-classes obo:IMR_0000229c

Rafc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000231
Super-classes obo:IMR_0000229c
Sub-classes obo:IMR_0100355c
obo:IMR_0000675c
obo:IMR_0000674c

TAK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000232
Super-classes obo:IMR_0000229c

Tpl2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000233
Super-classes obo:IMR_0000229c

MEKKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000234
Super-classes obo:IMR_0000229c
Sub-classes obo:IMR_0100450c
obo:IMR_0100222c
obo:IMR_0100451c

PAKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000238
Super-classes obo:IMR_0000252c
obo:IMR_0000229c
Sub-classes obo:IMR_0000671c
obo:IMR_0000672c
obo:IMR_0000670c
obo:IMR_0100356c
obo:IMR_0000669c
obo:IMR_0000673c

MLK familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000239
Super-classes obo:IMR_0000229c
Sub-classes obo:IMR_0100248c
obo:IMR_0100249c
obo:IMR_0100254c

NIKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000242
Super-classes obo:IMR_0000229c

IKK complexc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000243
Super-classes obo:TXPO_0002107c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c

cytokeratin 6Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000244
Super-classes obo:IMR_0000469c

PKCc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000245
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0000247c
obo:IMR_0000246c
obo:IMR_0100486c

nPKCc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000246
Super-classes obo:IMR_0000245c
Sub-classes obo:IMR_0001148c
obo:IMR_0100484c
obo:IMR_0001149c
obo:IMR_0001150c

aPKCc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000247
Super-classes obo:IMR_0000245c
Sub-classes obo:IMR_0001152c
obo:IMR_0001151c

RSKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000248
Super-classes obo:IMR_0001844c
obo:IMR_0100271c
Sub-classes obo:IMR_0001847c
obo:IMR_0001848c
obo:IMR_0001846c

PKAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000249
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c

Aktc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000250
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100846c
obo:IMR_0100844c
obo:IMR_0100845c

PKGc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000251
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0000676c
obo:IMR_0000677c

Ste20 homolog familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000252
Super-classes obo:IMR_0100207c
Sub-classes obo:IMR_0000238c
obo:IMR_0000253c

mammalian Ste20-like kinases (MAPKKKK)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000253
Super-classes obo:IMR_0000252c
Sub-classes obo:IMR_0100535c

G-protein coupled receptor kinasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000254
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0002955c

PDKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000255
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c

Plkc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000256
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0000679c
obo:IMR_0000680c

GSK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000257
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100736c

MAPKKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000259
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0002002c
Sub-classes obo:IMR_0000262c
obo:IMR_0000261c
obo:IMR_0000263c
obo:IMR_0100224c

MEK1/2(MKK1/2)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000261
Super-classes obo:IMR_0000259c
Sub-classes obo:IMR_0100453c
obo:IMR_0100452c

MKK4/7(JNKK1/2)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000262
Super-classes obo:IMR_0000259c
Sub-classes obo:IMR_0100455c
obo:IMR_0100454c

MKK3/6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000263
Super-classes obo:IMR_0000259c
Sub-classes obo:IMR_0100456c
obo:IMR_0100457c

PI3-kinasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000265
Super-classes obo:TXPO_0003223c

PI3-kinase p85 subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000266
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c
Sub-classes obo:IMR_0100590c
obo:IMR_0100589c

PI3-kinase p110 subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000267
Super-classes obo:TXPO_0003223c
Sub-classes obo:IMR_0100592c
obo:IMR_0100594c
obo:IMR_0100593c

RIPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000269
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c

SHIPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000271
Super-classes obo:CHEBI_25367c

SHP familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000274
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0000275c
obo:IMR_0000276c

SHP-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000275
Super-classes obo:IMR_0000274c

SHP-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000276
Super-classes obo:IMR_0000274c

PLA2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000283
Super-classes obo:TXPO_0000635c
Restrictions obo:TXPO_0002260op some obo:IMR_0000283c
obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:IMR_0001040c
obo:TXPO_0001804c
obo:TXPO_0003555c
obo:IMR_0001033c
obo:IMR_0001032c
obo:IMR_0001031c
obo:IMR_0001034c
obo:IMR_0001036c
obo:IMR_0001030c
obo:TXPO_1000283c
obo:IMR_0001042c
obo:IMR_0001041c
obo:IMR_0001035c
obo:IMR_0001038c
obo:TXPO_1000282c
obo:IMR_0001037c
obo:TXPO_0003556c
obo:TXPO_0000772c
obo:IMR_0001039c

PLC (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000284
Super-classes obo:TXPO_0000635c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:IMR_0000285c
obo:IMR_0000286c
obo:TXPO_0001805c

PLC gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000285
Super-classes obo:IMR_0000284c
Sub-classes obo:IMR_0000733c
obo:IMR_0000732c

PLCbetac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000286
Super-classes obo:IMR_0000284c
Sub-classes obo:IMR_0000717c
obo:IMR_0000715c
obo:IMR_0000716c
obo:IMR_0000714c

PLDc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000287
Super-classes obo:TXPO_0000635c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:IMR_0000729c
obo:IMR_0000728c

Ras familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000289
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003669c
Sub-classes obo:IMR_0000292c
obo:IMR_0000293c
obo:IMR_0000294c
obo:IMR_0000290c

Rasc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000290
Super-classes obo:IMR_0000289c
Sub-classes obo:IMR_0000291c
obo:IMR_0000695c
obo:IMR_0000696c

KRAS (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000291
Super-classes obo:IMR_0000290c
Sub-classes obo:TXPO_0004894c
obo:TXPO_0004895c
obo:IMR_0000698c
obo:IMR_0000697c

R-Rasc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000292
Super-classes obo:IMR_0000289c
Sub-classes obo:IMR_0001534c
obo:IMR_0001533c
obo:IMR_0001532c

Ralc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000293
Super-classes obo:IMR_0000289c
Sub-classes obo:IMR_0001528c
obo:IMR_0001527c

Rapc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000294
Super-classes obo:IMR_0000289c
Sub-classes obo:IMR_0001507c
obo:IMR_0001504c

Rho familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000295
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003669c
Sub-classes obo:IMR_0000296c
obo:IMR_0000297c
obo:IMR_0000699c

Rhoc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000296
Super-classes obo:IMR_0000295c
Sub-classes obo:IMR_0001953c

Racc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000297
Super-classes obo:IMR_0000295c
Sub-classes obo:IMR_0001502c
obo:IMR_0001503c
obo:IMR_0001501c

Rabc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000299
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003669c
Sub-classes obo:IMR_0001572c
obo:IMR_0001577c
obo:IMR_0001579c
obo:IMR_0001552c
obo:IMR_0001604c
obo:IMR_0001607c
obo:IMR_0001616c
obo:IMR_0001611c
obo:IMR_0001569c
obo:IMR_0001582c
obo:IMR_0001573c
obo:IMR_0001592c
obo:IMR_0001646c
obo:IMR_0001612c
obo:IMR_0001581c
obo:IMR_0001636c
obo:IMR_0001558c
obo:IMR_0001556c
obo:IMR_0001618c
obo:IMR_0001628c
obo:IMR_0001586c
obo:IMR_0001625c
obo:IMR_0001610c
obo:IMR_0001606c
obo:IMR_0001626c
obo:IMR_0001580c
obo:IMR_0001603c
obo:IMR_0001623c
obo:IMR_0001568c
obo:IMR_0001605c
obo:IMR_0001634c
obo:IMR_0001588c
obo:IMR_0001633c
obo:IMR_0001589c
obo:IMR_0001627c
obo:IMR_0001553c
obo:IMR_0001602c
obo:IMR_0001629c
obo:IMR_0001547c
obo:IMR_0001624c
obo:IMR_0001549c
obo:IMR_0001593c
obo:IMR_0001614c
obo:IMR_0001598c
obo:IMR_0001608c
obo:IMR_0001595c
obo:IMR_0001565c
obo:IMR_0001564c
obo:IMR_0001560c
obo:IMR_0001563c
obo:IMR_0001567c
obo:IMR_0001632c
obo:IMR_0001617c
obo:IMR_0001635c
obo:IMR_0001601c
obo:IMR_0001574c
obo:IMR_0001645c
obo:IMR_0001578c
obo:IMR_0001613c

Ranc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000300
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000885c
obo:RO_0000087op some obo:TXPO_0003669c

Arf/Sarc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000301
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003669c

proteasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000304
Super-classes obo:TXPO_0003663c

caspase (family)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000305
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000304c
Sub-classes obo:IMR_0100308c
obo:IMR_0000306c
obo:IMR_0100305c
obo:IMR_0100306c
obo:IMR_0100304c
obo:TXPO_0000502c
obo:IMR_0000308c
obo:IMR_0100307c
obo:IMR_0100309c
obo:IMR_0100302c

effector caspasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000306
Super-classes obo:IMR_0000305c
Sub-classes obo:TXPO_0001145c
obo:IMR_0100299c
obo:IMR_0100298c
obo:IMR_0100297c

signaling (initiator) caspasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000308
Super-classes obo:IMR_0000305c
Sub-classes obo:IMR_0100301c
obo:IMR_0100300c
obo:IMR_0100303c

26S proteasomec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000310
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000304c

G-alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000316
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003668c
Sub-classes obo:IMR_0000323c
obo:IMR_0000324c
obo:IMR_0000318c
obo:IMR_0000317c

G-alpha-s classc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000317
Super-classes obo:IMR_0000316c
Sub-classes obo:IMR_0100366c
obo:IMR_0100367c

G-alpha-i classc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000318
Super-classes obo:IMR_0000316c
Sub-classes obo:IMR_0000320c
obo:IMR_0000322c
obo:IMR_0000321c
obo:IMR_0000319c

G-alpha-ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0000319
Super-classes obo:IMR_0000318c
Sub-classes obo:IMR_0100369c
obo:IMR_0100368c
obo:IMR_0100370c

G-alpha-oc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000320
Super-classes obo:IMR_0000318c

G-alpha-tc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000321
Super-classes obo:IMR_0000318c
Sub-classes obo:IMR_0100373c
obo:IMR_0100374c

G-alpha-zc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000322
Super-classes obo:IMR_0000318c

G-alpha-q classc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000323
Super-classes obo:IMR_0000316c
Sub-classes obo:IMR_0100376c
obo:IMR_0100375c
obo:IMR_0100377c
obo:IMR_0100379c
obo:IMR_0100378c

G-alpha-12/13 classc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000324
Super-classes obo:IMR_0000316c
Sub-classes obo:IMR_0100381c
obo:IMR_0100380c

ubiquitin activating enzymec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000327
Description

related molecular function GO:0004839
Super-classes obo:TXPO_0003660c
Restrictions obo:TXPO_0000178op some owl:Thingc

COXc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000331
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000519c
Sub-classes obo:IMR_0000735c
obo:IMR_0000734c

Crkc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000335
Super-classes obo:IMR_0000745c
Sub-classes obo:IMR_0000336c
obo:IMR_0000338c

Crk Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0000336
Super-classes obo:IMR_0000335c

Crk-Lc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000337
Super-classes obo:IMR_0000745c

Crk IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000338
Super-classes obo:IMR_0000335c

Grb2 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000339
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003681c
Sub-classes obo:IMR_0000741c
obo:IMR_0000340c
obo:IMR_0000341c

Grb2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000340
Super-classes obo:IMR_0000339c

Grapc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000341
Super-classes obo:IMR_0000339c

Nck familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000342
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003681c
Sub-classes obo:IMR_0000344c
obo:IMR_0000343c

Nckc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000343
Super-classes obo:IMR_0000342c

Nck beta/Grb4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000344
Super-classes obo:IMR_0000342c

Shcc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000347
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003684c
Sub-classes obo:IMR_0000739c
obo:IMR_0000740c
obo:IMR_0000738c

SLP-76c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000350
Super-classes obo:IMR_0100258c

IRSc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000351
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003684c
Sub-classes obo:IMR_0100393c
obo:IMR_0100395c
obo:IMR_0100396c
obo:IMR_0100394c

cytokeratin 9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000352
Super-classes obo:IMR_0000035c

BLNK/SLP-65c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000353
Super-classes obo:IMR_0100258c

Cblc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000356
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003657c
Sub-classes obo:IMR_0100364c
obo:IMR_0100363c

Grb7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000357
Super-classes obo:IMR_0100382c

cytokeratin 10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000362
Super-classes obo:IMR_0000035c

cytokeratin 12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000363
Super-classes obo:IMR_0000035c

cytokeratin 13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000364
Super-classes obo:IMR_0000035c

cytokeratin 14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000365
Super-classes obo:IMR_0000035c

cytokeratin 15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000366
Super-classes obo:IMR_0000035c

cytokeratin 16c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000367
Super-classes obo:IMR_0000035c

Smadc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000370
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003720c
Sub-classes obo:IMR_0000372c
obo:IMR_0000371c
obo:IMR_0000373c

R-Smadc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000371
Super-classes obo:IMR_0000370c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0100504c
obo:IMR_0100507c

Co-Smadc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000372
Super-classes obo:IMR_0000370c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0100315c

I-Smadc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000373
Super-classes obo:IMR_0000370c
Sub-classes obo:IMR_0100317c
obo:IMR_0100318c

STATc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000374
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000378c
obo:IMR_0100733c
obo:IMR_0000375c
obo:IMR_0000376c
obo:IMR_0000381c
obo:IMR_0000377c

STAT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000375
Super-classes obo:IMR_0000374c
Sub-classes obo:TXPO_0003649c

STAT2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000376
Super-classes obo:IMR_0000374c

STAT3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000377
Super-classes obo:IMR_0000374c
Sub-classes obo:TXPO_0004318c
obo:TXPO_0004808c

STAT4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000378
Super-classes obo:IMR_0000374c

STAT5ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000379
Super-classes obo:IMR_0100733c

STAT5bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000380
Super-classes obo:IMR_0100733c

STAT6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000381
Super-classes obo:IMR_0000374c

NF-kappaBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000382
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000700c
obo:IMR_0100446c
obo:IMR_0000873c
obo:IMR_0100447c

Myc (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000383
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:TXPO_0004699c
obo:TXPO_0003983c
obo:TXPO_0004701c
obo:TXPO_0004700c
obo:TXPO_0003245c

IRF familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000386
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000395c
obo:IMR_0000390c
obo:IMR_0000391c
obo:IMR_0000393c
obo:IMR_0000392c
obo:IMR_0000388c
obo:IMR_0000387c
obo:IMR_0000389c
obo:IMR_0000394c

IRF-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000387
Super-classes obo:IMR_0000386c

IRF-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000388
Super-classes obo:IMR_0000386c

IRF-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000389
Super-classes obo:IMR_0000386c

IRF-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000390
Super-classes obo:IMR_0000386c

IRF-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000391
Super-classes obo:IMR_0000386c

IRF-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000392
Super-classes obo:IMR_0000386c

IRF-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000393
Super-classes obo:IMR_0000386c

ICSBPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000394
Super-classes obo:IMR_0000386c

p48c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000395
Super-classes obo:IMR_0000386c

etsc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000397
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000400c
obo:IMR_0000399c
obo:IMR_0001094c
obo:IMR_0001104c
obo:IMR_0001092c
obo:IMR_0001093c
obo:IMR_0000398c
obo:IMR_0001106c
obo:IMR_0001095c
obo:IMR_0002980c

ERGc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000398
Super-classes obo:IMR_0000397c

ETS1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000399
Super-classes obo:IMR_0000397c

ETS2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000400
Super-classes obo:IMR_0000397c

EGR familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000402
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000404c
obo:IMR_0000405c
obo:IMR_0000406c
obo:IMR_0000403c

EGR1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000403
Super-classes obo:IMR_0000402c
Sub-classes obo:TXPO_0003341c

EGR2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000404
Super-classes obo:IMR_0000402c

EGR3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000405
Super-classes obo:IMR_0000402c

EGR4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000406
Super-classes obo:IMR_0000402c

Mybc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000408
Super-classes obo:IMR_0000868c

NF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000409
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000870c
obo:IMR_0000869c
obo:IMR_0000871c
obo:IMR_0000872c

Maf familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000411
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000824c
obo:IMR_0000822c
obo:IMR_0000823c
obo:IMR_0000821c
obo:IMR_0000820c

cytokeratin 17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000413
Super-classes obo:IMR_0000035c

AP-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000414
Super-classes obo:TXPO_0002107c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

FOS familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000415
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000816c
obo:IMR_0000815c
obo:IMR_0000814c
obo:IMR_0000813c

JUN (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000416
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000817c
obo:TXPO_0001948c
obo:TXPO_0003162c
obo:IMR_0000818c
obo:TXPO_0004670c
obo:TXPO_0000653c
obo:IMR_0000819c

BCL-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000417
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

TCF/LEF-1 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000418
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0100744c
obo:IMR_0100745c
obo:IMR_0100746c
obo:IMR_0100747c

NF-ATc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000421
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000857c
obo:IMR_0000855c
obo:IMR_0000858c
obo:IMR_0000856c

C/EBPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000422
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000835c
obo:IMR_0000836c
obo:IMR_0000834c
obo:IMR_0000838c
obo:IMR_0000837c

p300/CBPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000426
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001397c
obo:RO_0000087op some obo:TXPO_0003717c
Sub-classes obo:IMR_0001405c
obo:IMR_0001404c

RGSc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000431
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c
Sub-classes obo:IMR_0001665c
obo:IMR_0001667c
obo:IMR_0001672c
obo:IMR_0001664c
obo:IMR_0001662c
obo:IMR_0001659c
obo:IMR_0001669c
obo:IMR_0001663c
obo:IMR_0001660c
obo:IMR_0001673c
obo:IMR_0001675c
obo:IMR_0001668c
obo:IMR_0001674c
obo:IMR_0001671c
obo:IMR_0001677c
obo:IMR_0001666c
obo:IMR_0001676c
obo:IMR_0001661c
obo:IMR_0001670c

Axinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000432
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003721c
obo:RO_0000087op some obo:TXPO_0003657c
Sub-classes obo:IMR_0001215c
obo:IMR_0001216c

GEFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000433
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c
Sub-classes obo:IMR_0100205c
obo:IMR_0000438c
obo:IMR_0100440c
obo:IMR_0001954c

Vavc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000434
Super-classes obo:IMR_0001954c

Sosc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000435
Super-classes obo:IMR_0100440c
Sub-classes obo:IMR_0002063c
obo:IMR_0002064c

C3Gc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000436
Super-classes obo:IMR_0100440c

Dblc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000437
Super-classes obo:IMR_0001954c

cytohesinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000438
Super-classes obo:IMR_0000433c

RalGEFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000439
Super-classes obo:IMR_0100440c
Sub-classes obo:IMR_0100433c

RasGRFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000440
Super-classes obo:IMR_0100440c
Sub-classes obo:IMR_0100348c
obo:IMR_0100347c

GAP familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000442
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c
Sub-classes obo:IMR_0100206c
obo:IMR_0000443c
obo:IMR_0100268c
obo:IMR_0002759c
obo:IMR_0100269c
obo:IMR_0100270c

Ras GAPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000443
Super-classes obo:IMR_0000442c
Sub-classes obo:IMR_0001107c
obo:IMR_0100429c
obo:IMR_0100430c
obo:IMR_0001115c
obo:IMR_0001116c
obo:IMR_0100431c
obo:IMR_0100428c
obo:IMR_0001117c

GDIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000444
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c

CKIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000445
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c
Sub-classes obo:IMR_0000447c
obo:IMR_0000446c
obo:IMR_0100645c

Cip/Kip familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000446
Super-classes obo:IMR_0000445c
Sub-classes obo:IMR_0100383c
obo:IMR_0100384c
obo:IMR_0100385c

INK4 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000447
Super-classes obo:IMR_0000445c

Bcl-2 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000451
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000327c
Sub-classes obo:IMR_0100705c
obo:IMR_0100707c

BAKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000452
Super-classes obo:IMR_0100708c
Sub-classes obo:TXPO_1000040c

BAX (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000453
Super-classes obo:IMR_0100708c
Sub-classes obo:TXPO_0004356c
obo:TXPO_0003190c
obo:TXPO_0003236c

IAP-familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000454
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000327c
Sub-classes obo:IMR_0100330c
obo:IMR_0100331c
obo:IMR_0100328c
obo:IMR_0100329c
obo:IMR_0100332c

14-3-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000456
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003721c
obo:RO_0000087op some obo:TXPO_0003720c
Sub-classes obo:IMR_0000863c
obo:IMR_0000860c
obo:IMR_0000864c
obo:IMR_0000865c
obo:IMR_0000861c
obo:IMR_0000859c
obo:IMR_0000862c

cytokeratin 18c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000458
Super-classes obo:IMR_0000035c

cytokeratin 19c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000459
Super-classes obo:IMR_0000035c

SOCSc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000460
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003720c
Sub-classes obo:IMR_0100843c
obo:IMR_0100838c
obo:IMR_0100840c
obo:IMR_0100837c
obo:IMR_0100839c
obo:IMR_0100842c
obo:IMR_0100841c

TRAF familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000462
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003657c
Sub-classes obo:IMR_0100422c
obo:IMR_0100425c
obo:IMR_0100427c
obo:IMR_0100424c
obo:IMR_0100426c
obo:IMR_0100423c

I-kappaB familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000463
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003720c
Sub-classes obo:IMR_0000464c

I-kappaBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000464
Super-classes obo:IMR_0000463c
Sub-classes obo:IMR_0100281c
obo:IMR_0100282c
obo:IMR_0100280c

cytokeratin 20c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000466
Super-classes obo:IMR_0000035c

cytokeratin 23c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000467
Super-classes obo:IMR_0000035c

cytokeratin 6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000469
Super-classes obo:IMR_0000050c
Sub-classes obo:IMR_0000165c
obo:IMR_0000244c
obo:IMR_0000208c

cytokeratin 21c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000471
Super-classes obo:IMR_0000035c

NF-Hc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000472
Super-classes obo:IMR_0000203c

NF-Lc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000474
Super-classes obo:IMR_0000203c

NF-Mc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000475
Super-classes obo:IMR_0000203c

alpha-actinin 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000479
Super-classes obo:IMR_0000189c

alpha-actinin 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000483
Super-classes obo:IMR_0000189c

alpha-actinin 3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000484
Super-classes obo:IMR_0000189c

alpha-actinin 4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000485
Super-classes obo:IMR_0000189c

beta-actinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000486
Super-classes obo:IMR_0000190c

alpha-cardiac actinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000487
Super-classes obo:IMR_0000490c

gamma-actinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000488
Super-classes obo:IMR_0000190c

alpha-actin 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000489
Super-classes obo:IMR_0000490c

alpha-actinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000490
Super-classes obo:IMR_0000190c
Sub-classes obo:IMR_0000492c
obo:IMR_0000487c
obo:IMR_0000489c
obo:IMR_0000491c

alpha-actin 3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000491
Super-classes obo:IMR_0000490c

alpha-actin 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000492
Super-classes obo:IMR_0000490c

caveolinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000515
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003657c
Sub-classes obo:IMR_0001647c
obo:IMR_0001649c
obo:IMR_0001648c

arrestinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000520
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003691c
Sub-classes obo:IMR_0002957c
obo:IMR_0002956c

Aquaporinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000522
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003696c

connexinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000526
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003691c

myelin proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000535
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003691c

collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000541
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003695c
Sub-classes obo:IMR_0001124c
obo:IMR_0000542c
obo:IMR_0000544c
obo:IMR_0001118c

fibrillar collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000542
Super-classes obo:IMR_0000541c

fibril-associated collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000544
Super-classes obo:IMR_0000541c

fibronectinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000546
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003695c

elastinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000547
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003695c

type IV collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000551
Super-classes obo:IMR_0001124c

proteoglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000552
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003695c
Sub-classes obo:IMR_0001127c
obo:IMR_0001126c
obo:IMR_0001125c
obo:IMR_0001128c

laminin familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000554
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003695c
Sub-classes obo:IMR_0000555c

kalininc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000555
Super-classes obo:IMR_0000554c

disabledc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000558
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0000809c
obo:IMR_0000808c

GADD45c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000559
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0000805c
obo:IMR_0000807c
obo:IMR_0000806c

presenilinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000560
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000304c
Sub-classes obo:IMR_0100731c
obo:IMR_0100732c

P-cadherinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000568
Super-classes obo:IMR_0000167c

K-cadherinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000569
Super-classes obo:IMR_0000167c

IFN alpha-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000572
Super-classes obo:IMR_0100386c

IFN alpha-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000573
Super-classes obo:IMR_0100386c

IFN alpha-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000574
Super-classes obo:IMR_0100386c

IFN alpha-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000575
Super-classes obo:IMR_0100386c

IFN alpha-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000576
Super-classes obo:IMR_0100386c

IFN alpha-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000577
Super-classes obo:IMR_0100386c

IFN alpha-8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000578
Super-classes obo:IMR_0100386c

IFN alpha-9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000579
Super-classes obo:IMR_0100386c

IFN alpha-10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000580
Super-classes obo:IMR_0100386c

IFN alpha-14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000581
Super-classes obo:IMR_0100386c

IFN alpha-16c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000582
Super-classes obo:IMR_0100386c

IFN alpha-17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000583
Super-classes obo:IMR_0100386c

IFN alpha-21c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000584
Super-classes obo:IMR_0100386c

IL-4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000585
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
Sub-classes obo:TXPO_0003193c

IL-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000586
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000587
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000588
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-10 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000589
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c
Sub-classes obo:TXPO_0003192c

IL-12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000590
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-1RI : IL-1R AcPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000593
Super-classes obo:IMR_0000120c

IL-1RII : IL-1R AcPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000594
Super-classes obo:IMR_0000120c

IL-13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000595
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000596
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000597
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-16c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000598
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000599
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-17 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000600
Super-classes obo:IMR_0000096c

IL-18c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000601
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-12 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000602
Super-classes obo:IMR_0000096c

IL-8 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000605
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0002260op some obo:IMR_0000096c
obo:RO_0000087op some obo:TXPO_0003561c
Sub-classes obo:IMR_0000607c
obo:IMR_0000606c

IL-8RAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000606
Super-classes obo:IMR_0000605c

IL-8RBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000607
Super-classes obo:IMR_0000605c

IL-10 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000608
Super-classes obo:IMR_0000096c

IL-11 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000611
Super-classes obo:IMR_0000096c

neuregulin-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000614
Super-classes obo:IMR_0000048c

neuregulin-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000615
Super-classes obo:IMR_0000048c

neuregulin-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000616
Super-classes obo:IMR_0000048c

neuregulin-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000617
Super-classes obo:IMR_0000048c

ICAM-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000618
Super-classes obo:IMR_0000178c

ICAM-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000619
Super-classes obo:IMR_0000178c

ICAM-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000620
Super-classes obo:IMR_0000178c

ICAM-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000621
Super-classes obo:IMR_0000178c

ICAM-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000622
Super-classes obo:IMR_0000178c

Integrin alpha-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000623
Super-classes obo:IMR_0000173c

Integrin alpha-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000624
Super-classes obo:IMR_0000173c

Integrin alpha-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000625
Super-classes obo:IMR_0000173c

Integrin alpha-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000626
Super-classes obo:IMR_0000173c

Integrin alpha-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000627
Super-classes obo:IMR_0000173c

Integrin alpha-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000628
Super-classes obo:IMR_0000173c

Integrin alpha-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000629
Super-classes obo:IMR_0000173c

Integrin alpha-8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000630
Super-classes obo:IMR_0000173c

Integrin alpha-9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000631
Super-classes obo:IMR_0000173c

Integrin alpha-10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000632
Super-classes obo:IMR_0000173c

Integrin alpha-11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000633
Super-classes obo:IMR_0000173c

Integrin alpha-IIbc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000634
Super-classes obo:IMR_0000173c

Integrin alpha-Dc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000635
Super-classes obo:IMR_0000173c

Integrin alpha-Ec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000636
Super-classes obo:IMR_0000173c

Integrin alpha-Lc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000637
Super-classes obo:IMR_0000173c

Integrin alpha-Mc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000638
Super-classes obo:IMR_0000173c

Integrin alpha-Vc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000639
Super-classes obo:IMR_0000173c

Integrin alpha-Xc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000640
Super-classes obo:IMR_0000173c

Integrin beta-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000641
Super-classes obo:IMR_0000174c

Integrin beta-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000642
Super-classes obo:IMR_0000174c

Integrin beta-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000643
Super-classes obo:IMR_0000174c

Integrin beta-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000644
Super-classes obo:IMR_0000174c

Integrin beta-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000645
Super-classes obo:IMR_0000174c

Integrin beta-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000646
Super-classes obo:IMR_0000174c

Integrin beta-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000647
Super-classes obo:IMR_0000174c

Integrin beta-8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000648
Super-classes obo:IMR_0000174c

CD44 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000649
Super-classes obo:IMR_0001125c
Sub-classes obo:TXPO_0004025c

LFA-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000650
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003688c

PAK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000669
Super-classes obo:IMR_0000238c

PAK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000670
Super-classes obo:IMR_0000238c

PAK4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000671
Super-classes obo:IMR_0000238c

PAK6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000672
Super-classes obo:IMR_0000238c

PAK7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000673
Super-classes obo:IMR_0000238c

A-Rafc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000674
Super-classes obo:IMR_0000231c

B-Rafc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000675
Super-classes obo:IMR_0000231c

cGMP-dependent protein kinase Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0000676
Super-classes obo:IMR_0000251c

cGMP-dependent protein kinase IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000677
Super-classes obo:IMR_0000251c

Plk1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000679
Super-classes obo:IMR_0000256c

Plk3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000680
Super-classes obo:IMR_0000256c

JNK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000683
Super-classes obo:IMR_0000225c

JNK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000684
Super-classes obo:IMR_0000225c

JNK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000685
Super-classes obo:IMR_0000225c

p38alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000686
Super-classes obo:IMR_0000226c

p38betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000687
Super-classes obo:IMR_0000226c

p38gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000688
Super-classes obo:IMR_0000226c

p38deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000689
Super-classes obo:IMR_0000226c

HRAS (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000695
Super-classes obo:IMR_0000290c
Sub-classes obo:TXPO_0004893c

NRAS (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000696
Super-classes obo:IMR_0000290c
Sub-classes obo:TXPO_0004896c

K-Ras2Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000697
Super-classes obo:IMR_0000291c

K-Ras2Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000698
Super-classes obo:IMR_0000291c

Cdc42c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000699
Super-classes obo:IMR_0000295c

p50:RelAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000700
Super-classes obo:IMR_0000382c

IKK familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000701
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100461c
obo:IMR_0100460c
obo:IMR_0100458c
obo:IMR_0100459c

PLCbeta1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000714
Super-classes obo:IMR_0000286c

PLCbeta2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000715
Super-classes obo:IMR_0000286c

PLCbeta3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000716
Super-classes obo:IMR_0000286c

PLCbeta4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000717
Super-classes obo:IMR_0000286c

PLD1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000728
Super-classes obo:IMR_0000287c

PLD2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000729
Super-classes obo:IMR_0000287c

PLC gamma1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000732
Super-classes obo:IMR_0000285c
Sub-classes obo:TXPO_0000599c

PLC gamma2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000733
Super-classes obo:IMR_0000285c

COX-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000734
Super-classes obo:IMR_0000331c

COX-2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000735
Super-classes obo:IMR_0000331c
Sub-classes obo:TXPO_0004472c

Grb10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000736
Super-classes obo:IMR_0100382c

Grb14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000737
Super-classes obo:IMR_0100382c

ShcAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000738
Super-classes obo:IMR_0000347c

ShcBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000739
Super-classes obo:IMR_0000347c

ShcCc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000740
Super-classes obo:IMR_0000347c

Gadsc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000741
Super-classes obo:IMR_0000339c

Crk familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000745
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003681c
Sub-classes obo:IMR_0000337c
obo:IMR_0000335c

ryanodine receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000774
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0002628c
obo:RO_0000087op some obo:TXPO_0003161c

GADD45 alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000805
Super-classes obo:IMR_0000559c

GADD45 betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000806
Super-classes obo:IMR_0000559c

GADD45 gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000807
Super-classes obo:IMR_0000559c

disabled-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000808
Super-classes obo:IMR_0000558c

disabled-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000809
Super-classes obo:IMR_0000558c

CD80c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000811
Super-classes obo:IMR_0002950c

CD86c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000812
Super-classes obo:IMR_0002950c

c-FOSc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000813
Super-classes obo:IMR_0000415c

FOSBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000814
Super-classes obo:IMR_0000415c

FRA-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000815
Super-classes obo:IMR_0000415c

FRA-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000816
Super-classes obo:IMR_0000415c

c-JUNc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000817
Super-classes obo:IMR_0000416c

JUNB (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000818
Super-classes obo:IMR_0000416c

JUND (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000819
Super-classes obo:IMR_0000416c
Sub-classes obo:TXPO_0000853c

c-Mafc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000820
Super-classes obo:IMR_0000411c

MafFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000821
Super-classes obo:IMR_0000411c

MafGc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000822
Super-classes obo:IMR_0000411c

MafKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000823
Super-classes obo:IMR_0000411c

MafBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000824
Super-classes obo:IMR_0000411c

ATFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000825
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:TXPO_1000011c
obo:TXPO_1000012c
obo:IMR_0000833c
obo:IMR_0000827c
obo:TXPO_1000013c
obo:IMR_0000826c
obo:IMR_0000830c

ATF-1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000826
Super-classes obo:IMR_0000825c

ATF-2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000827
Super-classes obo:IMR_0000825c

ATF-5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000830
Super-classes obo:IMR_0000825c

ATF-6 alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000831
Super-classes obo:TXPO_1000013c

ATF-6 betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000832
Super-classes obo:TXPO_1000013c

ATF-7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000833
Super-classes obo:IMR_0000825c

C/EBP alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000834
Super-classes obo:IMR_0000422c

C/EBP betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000835
Super-classes obo:IMR_0000422c

C/EBP deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000836
Super-classes obo:IMR_0000422c

C/EBP gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000837
Super-classes obo:IMR_0000422c

C/EBP epsilonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000838
Super-classes obo:IMR_0000422c

NF-ATc1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000855
Super-classes obo:IMR_0000421c

NF-ATc2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000856
Super-classes obo:IMR_0000421c

NF-ATc3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000857
Super-classes obo:IMR_0000421c

NF-ATc4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000858
Super-classes obo:IMR_0000421c

14-3-3 betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000859
Super-classes obo:IMR_0000456c

14-3-3 gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000860
Super-classes obo:IMR_0000456c

14-3-3 epsilonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000861
Super-classes obo:IMR_0000456c

14-3-3 etac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000862
Super-classes obo:IMR_0000456c

14-3-3 sigmac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000863
Super-classes obo:IMR_0000456c

14-3-3 tau/thetac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000864
Super-classes obo:IMR_0000456c

14-3-3 zetac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000865
Super-classes obo:IMR_0000456c

A-Mybc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000866
Super-classes obo:IMR_0000868c

B-Mybc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000867
Super-classes obo:IMR_0000868c

Myb familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000868
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0000408c
obo:IMR_0000866c
obo:IMR_0000867c

NF1-Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000869
Super-classes obo:IMR_0000409c

NF1-Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000870
Super-classes obo:IMR_0000409c

NF1-Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000871
Super-classes obo:IMR_0000409c

NF1-Xc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000872
Super-classes obo:IMR_0000409c

p52c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000873
Super-classes obo:IMR_0000382c

fat-soluble vitaminc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000877
Super-classes obo:IMR_0001656c
Sub-classes obo:IMR_0100041c
obo:IMR_0100040c

TFIIAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000883
Super-classes obo:IMR_0000888c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c

TFIIDc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000884
Super-classes obo:IMR_0000888c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c

TFIIEc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000885
Super-classes obo:IMR_0000888c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c

TFIIFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000886
Super-classes obo:IMR_0000888c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c

TFIIHc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000887
Super-classes obo:IMR_0000888c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c

TFIIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000888
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c
Sub-classes obo:IMR_0000883c
obo:IMR_0010630c
obo:IMR_0000884c
obo:IMR_0000887c
obo:IMR_0000886c
obo:IMR_0000885c

IRAK-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000890
Super-classes obo:IMR_0100488c

IRAK-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000891
Super-classes obo:IMR_0100488c

IRAK-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000892
Super-classes obo:IMR_0100488c

Tollipc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000894
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003657c

40S ribosomal proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000896
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003687c
Sub-classes obo:IMR_0010536c
obo:IMR_0010551c
obo:IMR_0010560c
obo:IMR_0010546c
obo:IMR_0010542c
obo:IMR_0010539c
obo:IMR_0010537c
obo:IMR_0010540c
obo:IMR_0010538c
obo:IMR_0010552c
obo:IMR_0010547c
obo:IMR_0010561c
obo:IMR_0010557c
obo:IMR_0010544c
obo:IMR_0010535c
obo:IMR_0010563c
obo:IMR_0010549c
obo:IMR_0010447c
obo:IMR_0010541c
obo:IMR_0010556c
obo:IMR_0010554c
obo:IMR_0010545c
obo:IMR_0010555c
obo:IMR_0010548c
obo:IMR_0010565c
obo:IMR_0010553c
obo:IMR_0100711c
obo:IMR_0010559c
obo:IMR_0010564c
obo:IMR_0010543c
obo:IMR_0010558c
obo:IMR_0010567c
obo:IMR_0010550c

60S ribosomal proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000897
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003687c
Sub-classes obo:IMR_0010500c
obo:IMR_0010473c
obo:IMR_0010492c
obo:IMR_0010497c
obo:IMR_0010483c
obo:IMR_0010446c
obo:IMR_0010482c
obo:IMR_0010470c
obo:IMR_0010466c
obo:IMR_0010498c
obo:IMR_0010478c
obo:IMR_0010489c
obo:IMR_0010481c
obo:IMR_0010496c
obo:IMR_0010464c
obo:IMR_0010480c
obo:IMR_0010486c
obo:IMR_0010471c
obo:IMR_0010472c
obo:IMR_0010468c
obo:IMR_0010494c
obo:IMR_0010499c
obo:IMR_0010449c
obo:IMR_0010488c
obo:IMR_0010444c
obo:IMR_0010502c
obo:IMR_0010475c
obo:IMR_0010474c
obo:IMR_0010467c
obo:IMR_0010504c
obo:IMR_0010477c
obo:IMR_0010462c
obo:IMR_0010443c
obo:IMR_0010469c
obo:IMR_0010448c
obo:IMR_0010501c
obo:IMR_0010479c
obo:IMR_0010493c
obo:IMR_0010461c
obo:IMR_0010484c
obo:IMR_0010485c
obo:IMR_0010503c
obo:IMR_0010463c
obo:IMR_0010491c
obo:IMR_0010490c
obo:IMR_0010495c
obo:IMR_0010476c
obo:IMR_0010465c
obo:IMR_0010487c

eIF2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000902
Super-classes obo:IMR_0010016c
Restrictions obo:RO_0000087op some obo:TXPO_0003706c

eIF2Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000903
Super-classes obo:IMR_0010016c
Restrictions obo:TXPO_0002260op some obo:IMR_0000433c

eIF3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000904
Super-classes obo:IMR_0010016c

eIF4Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0000906
Super-classes obo:IMR_0000912c
Sub-classes obo:IMR_0011153c
obo:IMR_0011154c

eIF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000908
Super-classes obo:IMR_0010016c
Sub-classes obo:TXPO_0004064c

eIF4Fc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000909
Super-classes obo:IMR_0010016c

eIF4Gc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000910
Super-classes obo:IMR_0000912c
Sub-classes obo:IMR_0000911c
obo:IMR_0011157c

eIF4GIIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000911
Super-classes obo:IMR_0000910c

eIF4F subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000912
Super-classes obo:IMR_0010016c
Sub-classes obo:IMR_0011155c
obo:IMR_0000906c
obo:IMR_0000910c

eIF2 subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000913
Super-classes obo:IMR_0010016c
Sub-classes obo:IMR_0011135c
obo:IMR_0011134c
obo:IMR_0011133c

eIF2B subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000915
Super-classes obo:IMR_0010016c
Sub-classes obo:IMR_0011136c
obo:IMR_0011139c
obo:IMR_0011140c
obo:IMR_0011138c
obo:IMR_0011137c

eIF3 subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000916
Super-classes obo:IMR_0010016c
Sub-classes obo:IMR_0011144c
obo:IMR_0011147c
obo:IMR_0011149c
obo:IMR_0011143c
obo:IMR_0011146c
obo:IMR_0011148c
obo:IMR_0011150c
obo:IMR_0011141c
obo:IMR_0011142c
obo:IMR_0011151c
obo:IMR_0011145c

LRP3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000962
Super-classes obo:IMR_0100798c

LRP4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000963
Super-classes obo:IMR_0100798c

LRP5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000964
Super-classes obo:IMR_0002954c
obo:IMR_0100798c

chemical hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0000966
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0100083c
obo:IMR_0100089c
obo:IMR_0100033c
obo:IMR_0100072c
obo:IMR_0100087c
obo:IMR_0100084c
obo:IMR_0100086c
obo:IMR_0000051c
obo:IMR_0100042c
obo:IMR_0100076c
obo:IMR_0100082c
obo:IMR_0100045c
obo:IMR_0100143c

LRP6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000970
Super-classes obo:IMR_0002954c
obo:IMR_0100798c

LRP8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000973
Super-classes obo:IMR_0100798c

LDL receptor familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000974
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0000979c
obo:IMR_0002951c
obo:IMR_0100798c

LRP1Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000975
Super-classes obo:IMR_0100798c

LRP10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000976
Super-classes obo:IMR_0100798c

LRP11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000977
Super-classes obo:IMR_0100798c

LRP12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0000978
Super-classes obo:IMR_0100798c

LDL receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0000979
Super-classes obo:IMR_0000974c

cAMP-specific 3',5'-cyclic phosphodiesterase 4Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001016
Super-classes obo:IMR_0100700c

cAMP-specific 3',5'-cyclic phosphodiesterase 4Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001017
Super-classes obo:IMR_0100700c

cAMP-specific 3',5'-cyclic phosphodiesterase 4Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001018
Super-classes obo:IMR_0100700c

cAMP-specific 3',5'-cyclic phosphodiesterase 4Dc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001019
Super-classes obo:IMR_0100700c

High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001020
Super-classes obo:IMR_0100700c

cAMP-specific 3',5'-cyclic phosphodiesterase 7Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001021
Super-classes obo:IMR_0100700c

cGMP-specific 3',5'-cyclic phosphodiesterasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0001022
Super-classes obo:IMR_0100002c

High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001023
Super-classes obo:IMR_0100002c

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001024
Super-classes obo:IMR_0100002c

Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001025
Super-classes obo:IMR_0100002c

Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001026
Super-classes obo:IMR_0100002c

Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001027
Super-classes obo:IMR_0100002c

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase delta-subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001028
Super-classes obo:IMR_0100002c

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001029
Super-classes obo:IMR_0100002c

group III secretory phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001030
Super-classes obo:IMR_0000283c

group V phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001031
Super-classes obo:IMR_0000283c

group VI phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001032
Super-classes obo:IMR_0000283c

group IIA phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001033
Super-classes obo:IMR_0000283c

group IID secretory phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001034
Super-classes obo:IMR_0000283c

group IIE secretory phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001035
Super-classes obo:IMR_0000283c
Sub-classes obo:TXPO_0000736c

group IIF secretory phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001036
Super-classes obo:IMR_0000283c

group X secretory phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001037
Super-classes obo:IMR_0000283c

group XIIA secretory phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001038
Super-classes obo:IMR_0000283c

group XIIB secretory phospholipase A2-like proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001039
Super-classes obo:IMR_0000283c

group IVA phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001040
Super-classes obo:IMR_0000283c

group IVC phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001041
Super-classes obo:IMR_0000283c

group IIC secretory phospholipase A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001042
Super-classes obo:IMR_0000283c

thiolester hydrolasesc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001043
Super-classes obo:TXPO_0003663c
Sub-classes obo:IMR_0001044c

ubiquitin thiolesterasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0001044
Super-classes obo:IMR_0001043c

importin alpha1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001084
Super-classes obo:IMR_0100202c

importin alpha2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001085
Super-classes obo:IMR_0100202c

importin alpha3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001086
Super-classes obo:IMR_0100202c

importin alpha4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001087
Super-classes obo:IMR_0100202c

importin alpha6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001088
Super-classes obo:IMR_0100202c

importin alpha7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001089
Super-classes obo:IMR_0100202c

CRM1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001090
Super-classes obo:IMR_0100015c

importin/exportinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001091
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000885c
Sub-classes obo:IMR_0001109c
obo:IMR_0100015c
obo:IMR_0100010c
obo:IMR_0001110c

FLI1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001092
Super-classes obo:IMR_0000397c

ERMc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001093
Super-classes obo:IMR_0000397c

Elk-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001094
Super-classes obo:IMR_0000397c

Sap-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001095
Super-classes obo:IMR_0000397c

transportin 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001096
Super-classes obo:IMR_0100010c

transportin SRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001097
Super-classes obo:IMR_0100010c

exportin 4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001098
Super-classes obo:IMR_0100015c

exportin 7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001099
Super-classes obo:IMR_0100015c

exportin-tc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001100
Super-classes obo:IMR_0100015c

importin 5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001101
Super-classes obo:IMR_0100010c

importin 7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001102
Super-classes obo:IMR_0100010c

importin 11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001103
Super-classes obo:IMR_0100010c

Netc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001104
Super-classes obo:IMR_0000397c

importin 13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001105
Super-classes obo:IMR_0100015c
obo:IMR_0100010c

PU.1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001106
Super-classes obo:IMR_0000397c

IQGAP1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001107
Super-classes obo:IMR_0000443c

transportin 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001108
Super-classes obo:IMR_0100010c

RanBP17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001109
Super-classes obo:IMR_0001091c

RanBP6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001110
Super-classes obo:IMR_0001091c

importin 8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001111
Super-classes obo:IMR_0100010c

importin 4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001112
Super-classes obo:IMR_0100010c

importin 9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001113
Super-classes obo:IMR_0100010c

exportin 5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001114
Super-classes obo:IMR_0100015c

IQGAP2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001115
Super-classes obo:IMR_0000443c

RASAL1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001116
Super-classes obo:IMR_0000443c

RASA4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001117
Super-classes obo:IMR_0000443c

short chain collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001118
Super-classes obo:IMR_0000541c
Sub-classes obo:IMR_0001123c
obo:IMR_0001122c

type X collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001122
Super-classes obo:IMR_0001118c

type VIII collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001123
Super-classes obo:IMR_0001118c

basement membrane collagenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001124
Super-classes obo:IMR_0000541c
Sub-classes obo:IMR_0000551c

heparan sulfate proteoglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001125
Super-classes obo:IMR_0000552c
Sub-classes obo:IMR_0001131c
obo:IMR_0100579c
obo:IMR_0001139c
obo:IMR_0001134c
obo:IMR_0000649c

chondroitin sulfate proteoglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001126
Super-classes obo:IMR_0000552c
Sub-classes obo:IMR_0001132c
obo:IMR_0001144c
obo:IMR_0001136c
obo:IMR_0001133c
obo:IMR_0001130c

chondroitin/dermatan sulfate proteoglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001127
Super-classes obo:IMR_0000552c
Sub-classes obo:IMR_0001137c
obo:IMR_0001143c

keratan sulfate proteoglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001128
Super-classes obo:IMR_0000552c
Sub-classes obo:IMR_0001129c
obo:IMR_0001138c

lumicanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001129
Super-classes obo:IMR_0001128c

neurocanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001130
Super-classes obo:IMR_0001126c

perlecanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001131
Super-classes obo:IMR_0001125c

versicanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001132
Super-classes obo:IMR_0001126c

aggrecanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001133
Super-classes obo:IMR_0001126c

agrinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001134
Super-classes obo:IMR_0001125c

brevicanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001136
Super-classes obo:IMR_0001126c

decorinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001137
Super-classes obo:IMR_0001127c

keratocanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001138
Super-classes obo:IMR_0001128c

glypican (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001139
Super-classes obo:IMR_0001125c
Sub-classes obo:IMR_0001142c
obo:IMR_0001140c
obo:TXPO_0004067c
obo:IMR_0002958c
obo:IMR_0001141c

glypican-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001140
Super-classes obo:IMR_0001139c

cerebroglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001141
Super-classes obo:IMR_0001139c

K-glypicanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001142
Super-classes obo:IMR_0001139c

biglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001143
Super-classes obo:IMR_0001127c

NG2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001144
Super-classes obo:IMR_0001126c

PKC alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001145
Super-classes obo:IMR_0100486c

PKC betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001146
Super-classes obo:IMR_0100486c

PKC gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001147
Super-classes obo:IMR_0100486c

PKC deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001148
Super-classes obo:IMR_0000246c

PKC epsilonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001149
Super-classes obo:IMR_0000246c

PKC etac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001150
Super-classes obo:IMR_0000246c

PKC zetac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001151
Super-classes obo:IMR_0000247c

PKC lambda/iotac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001152
Super-classes obo:IMR_0000247c

TRAILc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001200
Super-classes obo:IMR_0000021c

TRAIL-R1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001201
Super-classes obo:IMR_0000056c

TRAIL-R2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001202
Super-classes obo:IMR_0000056c

Apaf-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001204
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000327c

cytochrome cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001206
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000154c

Bmfc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001208
Super-classes obo:IMR_0100709c

DLC2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001209
Super-classes obo:IMR_0000200c

Noxac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001210
Super-classes obo:IMR_0100709c

Pumac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001211
Super-classes obo:IMR_0100709c

DLC1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001213
Super-classes obo:IMR_0000200c

Axin1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001215
Super-classes obo:IMR_0000432c

Axin2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001216
Super-classes obo:IMR_0000432c

cyclic nucleotidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0001355
Super-classes obo:CHEBI_36976c
Sub-classes obo:IMR_0100024c
obo:IMR_0100025c

GDPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001357
Super-classes obo:CHEBI_36976c

Gli1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001363
Super-classes obo:IMR_0001372c

Gli2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001366
Super-classes obo:IMR_0001372c

Gli3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001368
Super-classes obo:IMR_0001372c

Ci/Glic # Classes

URI http://purl.obolibrary.org/obo/IMR_0001372
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0001368c
obo:IMR_0001363c
obo:IMR_0001366c

inositol phosphatec # Classes

URI http://purl.obolibrary.org/obo/IMR_0001385
Super-classes obo:TXPO_0001122c
Sub-classes obo:IMR_0100028c
obo:IMR_0100698c
obo:IMR_0100029c

CBPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001404
Super-classes obo:IMR_0000426c

p300c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001405
Super-classes obo:IMR_0000426c

Gabc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001409
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003684c
Sub-classes obo:IMR_0001410c
obo:IMR_0001412c
obo:IMR_0001411c

Gab1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001410
Super-classes obo:IMR_0001409c
Sub-classes obo:TXPO_0001137c

Gab2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001411
Super-classes obo:IMR_0001409c

Gab3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001412
Super-classes obo:IMR_0001409c

ISGF3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001422
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

GAFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001423
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

BMP-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001424
Super-classes obo:IMR_0003083c

BMP-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001426
Super-classes obo:IMR_0000040c

BMP-3bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001427
Super-classes obo:IMR_0000040c

BMP-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001428
Super-classes obo:IMR_0003083c

BMP-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001429
Super-classes obo:IMR_0003084c

BMP-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001430
Super-classes obo:IMR_0003084c

BMP-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001431
Super-classes obo:IMR_0003084c

BMP-8ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001432
Super-classes obo:IMR_0003084c

BMP-8bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001433
Super-classes obo:IMR_0003084c

BMP-10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001434
Super-classes obo:IMR_0000040c

BMP-15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001435
Super-classes obo:IMR_0000040c

GDF-11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001436
Super-classes obo:IMR_0000040c

GDF-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001437
Super-classes obo:IMR_0000040c

TLR4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001440
Super-classes obo:IMR_0000124c
Sub-classes obo:TXPO_0004831c

TLR1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001449
Super-classes obo:IMR_0000124c

TLR2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001450
Super-classes obo:IMR_0000124c

TLR5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001451
Super-classes obo:IMR_0000124c

TLR3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001452
Super-classes obo:IMR_0000124c

TLR6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001455
Super-classes obo:IMR_0000124c

TLR7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001458
Super-classes obo:IMR_0000124c

TLR8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001461
Super-classes obo:IMR_0000124c

TLR9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001464
Super-classes obo:IMR_0000124c
Sub-classes obo:TXPO_0004235c
obo:TXPO_0004236c

DOCK180c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001468
Super-classes obo:IMR_0001469c

DOCKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001469
Super-classes obo:IMR_0001954c
Sub-classes obo:IMR_0001475c
obo:IMR_0001473c
obo:IMR_0001471c
obo:IMR_0001478c
obo:IMR_0001477c
obo:IMR_0001474c
obo:IMR_0001472c
obo:IMR_0001476c
obo:IMR_0001468c
obo:IMR_0001470c

DOCK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001470
Super-classes obo:IMR_0001469c

DOCK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001471
Super-classes obo:IMR_0001469c

DOCK4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001472
Super-classes obo:IMR_0001469c

DOCK5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001473
Super-classes obo:IMR_0001469c

DOCK6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001474
Super-classes obo:IMR_0001469c

DOCK7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001475
Super-classes obo:IMR_0001469c

DOCK8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001476
Super-classes obo:IMR_0001469c

DOCK9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001477
Super-classes obo:IMR_0001469c

DOCK10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001478
Super-classes obo:IMR_0001469c

Rac1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001501
Super-classes obo:IMR_0000297c

Rac2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001502
Super-classes obo:IMR_0000297c

Rac3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001503
Super-classes obo:IMR_0000297c

Rap1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001504
Super-classes obo:IMR_0000294c
Sub-classes obo:IMR_0001506c
obo:IMR_0001505c

Rap1Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001505
Super-classes obo:IMR_0001504c

Rap1Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001506
Super-classes obo:IMR_0001504c

Rap2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001507
Super-classes obo:IMR_0000294c
Sub-classes obo:IMR_0001508c
obo:IMR_0001510c
obo:IMR_0001509c

Rap2Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001508
Super-classes obo:IMR_0001507c

Rap2Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001509
Super-classes obo:IMR_0001507c

Rap2Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001510
Super-classes obo:IMR_0001507c

RalAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001527
Super-classes obo:IMR_0000293c

RalBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001528
Super-classes obo:IMR_0000293c

R-Ras1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001532
Super-classes obo:IMR_0000292c

R-Ras2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001533
Super-classes obo:IMR_0000292c

M-Rasc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001534
Super-classes obo:IMR_0000292c

Rab1Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001547
Super-classes obo:IMR_0000299c

Rab1Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001549
Super-classes obo:IMR_0000299c

Rab2Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001552
Super-classes obo:IMR_0000299c

Rab2Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001553
Super-classes obo:IMR_0000299c

Rab3Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001556
Super-classes obo:IMR_0000299c

Rab3Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001558
Super-classes obo:IMR_0000299c

Rab3Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001560
Super-classes obo:IMR_0000299c

Rab3Dc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001563
Super-classes obo:IMR_0000299c

Rab4Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001564
Super-classes obo:IMR_0000299c

Rab4Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001565
Super-classes obo:IMR_0000299c

Rab5Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001567
Super-classes obo:IMR_0000299c

Rab5Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001568
Super-classes obo:IMR_0000299c

Rab5Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001569
Super-classes obo:IMR_0000299c

Rab6Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001572
Super-classes obo:IMR_0000299c

Rab6Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001573
Super-classes obo:IMR_0000299c

Rab6Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001574
Super-classes obo:IMR_0000299c

Rab7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001577
Super-classes obo:IMR_0000299c

Rab7Lc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001578
Super-classes obo:IMR_0000299c

Rab8Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001579
Super-classes obo:IMR_0000299c

Rab8Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001580
Super-classes obo:IMR_0000299c

Rab9Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001581
Super-classes obo:IMR_0000299c

Rab9Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001582
Super-classes obo:IMR_0000299c

Rab10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001586
Super-classes obo:IMR_0000299c

Rab11Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001588
Super-classes obo:IMR_0000299c

Rab11Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001589
Super-classes obo:IMR_0000299c

Rab12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001592
Super-classes obo:IMR_0000299c

Rab13 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001593
Super-classes obo:IMR_0000299c

Rab14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001595
Super-classes obo:IMR_0000299c

Rab15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001598
Super-classes obo:IMR_0000299c

Rab17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001601
Super-classes obo:IMR_0000299c

Rab18c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001602
Super-classes obo:IMR_0000299c

Rab19c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001603
Super-classes obo:IMR_0000299c

Rab20c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001604
Super-classes obo:IMR_0000299c

Rab21c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001605
Super-classes obo:IMR_0000299c

Rab22Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001606
Super-classes obo:IMR_0000299c

Rab23c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001607
Super-classes obo:IMR_0000299c

Rab24c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001608
Super-classes obo:IMR_0000299c

Rab25c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001610
Super-classes obo:IMR_0000299c

Rab26c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001611
Super-classes obo:IMR_0000299c

Rab27Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001612
Super-classes obo:IMR_0000299c

Rab27Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001613
Super-classes obo:IMR_0000299c

Rab28c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001614
Super-classes obo:IMR_0000299c

Rab30c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001616
Super-classes obo:IMR_0000299c

Rab31c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001617
Super-classes obo:IMR_0000299c

Rab32c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001618
Super-classes obo:IMR_0000299c

Rab33Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001623
Super-classes obo:IMR_0000299c

Rab33B (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001624
Super-classes obo:IMR_0000299c

Rab34c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001625
Super-classes obo:IMR_0000299c

Rab35c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001626
Super-classes obo:IMR_0000299c

Rab36c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001627
Super-classes obo:IMR_0000299c

Rab37c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001628
Super-classes obo:IMR_0000299c

Rab38c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001629
Super-classes obo:IMR_0000299c

Rab39Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001632
Super-classes obo:IMR_0000299c

Rab39Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001633
Super-classes obo:IMR_0000299c

Rab40Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001634
Super-classes obo:IMR_0000299c

Rab40Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001635
Super-classes obo:IMR_0000299c

Rab40Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001636
Super-classes obo:IMR_0000299c

RABL2Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0001645
Super-classes obo:IMR_0000299c

RABL2Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001646
Super-classes obo:IMR_0000299c

caveolin-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001647
Super-classes obo:IMR_0000515c

caveolin-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001648
Super-classes obo:IMR_0000515c

caveolin-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001649
Super-classes obo:IMR_0000515c

vitaminc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001656
Super-classes obo:CHEBI_72695c
Sub-classes obo:IMR_0000877c

RGS1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001659
Super-classes obo:IMR_0000431c

RGS2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001660
Super-classes obo:IMR_0000431c

RGS3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001661
Super-classes obo:IMR_0000431c

RGS4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001662
Super-classes obo:IMR_0000431c

RGS5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001663
Super-classes obo:IMR_0000431c

RGS6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001664
Super-classes obo:IMR_0000431c

RGS7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001665
Super-classes obo:IMR_0000431c

RGS8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001666
Super-classes obo:IMR_0000431c

RGS9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001667
Super-classes obo:IMR_0000431c

RGS10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001668
Super-classes obo:IMR_0000431c

RGS11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001669
Super-classes obo:IMR_0000431c

RGS12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001670
Super-classes obo:IMR_0000431c

RGS13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001671
Super-classes obo:IMR_0000431c

RGS14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001672
Super-classes obo:IMR_0000431c

RGS16c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001673
Super-classes obo:IMR_0000431c

RGS17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001674
Super-classes obo:IMR_0000431c

RGS18c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001675
Super-classes obo:IMR_0000431c

RGS19c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001676
Super-classes obo:IMR_0000431c

RGS20c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001677
Super-classes obo:IMR_0000431c

MAPKAPK2/3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001689
Super-classes obo:IMR_0100271c
Sub-classes obo:IMR_0100266c
obo:IMR_0100267c

MNK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001690
Super-classes obo:IMR_0100273c

MNK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001691
Super-classes obo:IMR_0100273c

HSP27c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001692
Super-classes obo:CHEBI_25367c

aminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0001693
Super-classes obo:CHEBI_72695c
Sub-classes obo:TXPO_0001572c
obo:IMR_0002121c

catecholaminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0001694
Super-classes obo:IMR_0002121c
Sub-classes obo:IMR_0100113c
obo:IMR_0100115c
obo:IMR_0100114c

glycosidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0001698
Super-classes obo:CHEBI_16646c
Sub-classes obo:CHEBI_36976c
obo:CHEBI_33838c

peptidoglycanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001699
Super-classes obo:CHEBI_18154c

vinculinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001711
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000188c

beta-1,3-glucanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001789
Super-classes obo:CHEBI_18154c

S6Kc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001844
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0001845c
obo:IMR_0000248c

p70S6Kc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001845
Super-classes obo:IMR_0001844c
Sub-classes obo:IMR_0002798c
obo:IMR_0002799c

RSK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001846
Super-classes obo:IMR_0000248c

RSK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001847
Super-classes obo:IMR_0000248c

RSK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001848
Super-classes obo:IMR_0000248c

ADAM familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001865
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000304c
Sub-classes obo:TXPO_1000028c
obo:IMR_0001871c
obo:IMR_0001867c

TACEc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001867
Super-classes obo:IMR_0001865c

ADAM10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001871
Super-classes obo:IMR_0001865c

MAM familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001923
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003717c
Sub-classes obo:IMR_0001924c

MAML1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001924
Super-classes obo:IMR_0001923c

RhoAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001953
Super-classes obo:IMR_0000296c

RhoGEFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001954
Super-classes obo:IMR_0000433c
Sub-classes obo:IMR_0000437c
obo:IMR_0000434c
obo:IMR_0003026c
obo:IMR_0001469c

Epacc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001967
Super-classes obo:IMR_0001976c
Sub-classes obo:IMR_0001968c
obo:IMR_0001969c

Epac1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001968
Super-classes obo:IMR_0001967c

Epac2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0001969
Super-classes obo:IMR_0001967c

RapGEFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0001976
Super-classes obo:IMR_0100440c
Sub-classes obo:IMR_0001967c

NDK5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002044
Super-classes obo:IMR_0010012c

NDK6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002046
Super-classes obo:IMR_0010012c

NDK7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002049
Super-classes obo:IMR_0010012c

FGFR1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002055
Super-classes obo:IMR_0000080c

FGFR2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002056
Super-classes obo:IMR_0000080c

FGFR3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002057
Super-classes obo:IMR_0000080c

FGFR4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002058
Super-classes obo:IMR_0000080c

Sos1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002063
Super-classes obo:IMR_0000435c

Sos2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002064
Super-classes obo:IMR_0000435c

immunoglobulinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002090
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0002094c
obo:IMR_0002093c
obo:IMR_0002091c

IgAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002091
Super-classes obo:IMR_0002090c

IgEc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002093
Super-classes obo:IMR_0002090c

IgGc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002094
Super-classes obo:IMR_0002090c

aldosteronec # Classes

URI http://purl.obolibrary.org/obo/IMR_0002120
Super-classes obo:IMR_0100037c

biogenic aminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0002121
Super-classes obo:IMR_0001693c
Sub-classes obo:IMR_0001694c
obo:IMR_0100123c
obo:IMR_0100111c
obo:IMR_0100125c
obo:IMR_0100069c
obo:IMR_0100122c
obo:IMR_0100124c

methionyl-lysyl-bradykininc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002126
Super-classes obo:IMR_0100165c

beta lipotropinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002345
Super-classes obo:IMR_0100197c

gamma lipotropinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002346
Super-classes obo:IMR_0100197c

TCR gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0002394
Super-classes obo:IMR_0000151c

TCR deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0002395
Super-classes obo:IMR_0000151c

UBE2Nc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002410
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000018c

Uev1Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0002411
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000018c

nonclassical MHC class I moleculec # Classes

URI http://purl.obolibrary.org/obo/IMR_0002515
Super-classes obo:IMR_0000142c

nonclassical MHC class II moleculec # Classes

URI http://purl.obolibrary.org/obo/IMR_0002516
Super-classes obo:IMR_0000142c

inositol 1,4,5-trisphosphate 3-kinasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0002576
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0002579c
obo:IMR_0002578c
obo:IMR_0002577c

inositol 1,4,5-trisphosphate 3-kinase Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0002577
Super-classes obo:IMR_0002576c

inositol 1,4,5-trisphosphate 3-kinase Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002578
Super-classes obo:IMR_0002576c

inositol 1,4,5-trisphosphate 3-kinase Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002579
Super-classes obo:IMR_0002576c

BCL10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002658
Super-classes obo:CHEBI_25367c

IGFBPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002688
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003720c
Sub-classes obo:IMR_0002693c
obo:TXPO_1000208c
obo:IMR_0002691c
obo:IMR_0002690c
obo:IMR_0002694c
obo:IMR_0002692c

IGFBP-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002690
Super-classes obo:IMR_0002688c

IGFBP-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002691
Super-classes obo:IMR_0002688c

IGFBP-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002692
Super-classes obo:IMR_0002688c

IGFBP-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002693
Super-classes obo:IMR_0002688c

IGFBP-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002694
Super-classes obo:IMR_0002688c

IL-23c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002716
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

IL-23 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002717
Super-classes obo:IMR_0000096c

IL-27c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002718
Super-classes obo:IMR_0000007c
Restrictions obo:RO_0000087op some obo:TXPO_0000622c

TORc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002721
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c

TSC2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002759
Super-classes obo:IMR_0000442c

AMPK beta subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002777
Super-classes obo:TXPO_0003221c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c

AMPK gamma subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002778
Super-classes obo:TXPO_0003221c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c

S6K1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002798
Super-classes obo:IMR_0001845c

S6K2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002799
Super-classes obo:IMR_0001845c

FOXO familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002804
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0002807c
obo:IMR_0002808c
obo:IMR_0002806c
obo:IMR_0002805c

FOXO1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002805
Super-classes obo:IMR_0002804c
Sub-classes obo:TXPO_0003924c
obo:TXPO_0005080c
obo:TXPO_0003923c

FOXO3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002806
Super-classes obo:IMR_0002804c

FOXO4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002807
Super-classes obo:IMR_0002804c

FOXO6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002808
Super-classes obo:IMR_0002804c

insulin familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002835
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100145c
obo:IMR_0100144c
obo:IMR_0000052c

CD80/CD86c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002950
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
Sub-classes obo:IMR_0000812c
obo:IMR_0000811c

Arrow/LRP5/LRP6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002951
Super-classes obo:IMR_0000974c
Sub-classes obo:IMR_0002954c

LRP5/LRP6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002954
Super-classes obo:IMR_0002951c
Sub-classes obo:IMR_0000964c
obo:IMR_0000970c

GRK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002955
Super-classes obo:IMR_0000254c

beta-arrestin 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002956
Super-classes obo:IMR_0000520c

beta-arrestin 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002957
Super-classes obo:IMR_0000520c

Dlp/Dallyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0002958
Super-classes obo:IMR_0001139c

TEL1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0002980
Super-classes obo:IMR_0000397c

Kif3Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0003014
Super-classes obo:IMR_0100193c

alpha PIXc # Classes

URI http://purl.obolibrary.org/obo/IMR_0003026
Super-classes obo:IMR_0001954c

BMP-1/TLD familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0003045
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000304c

GDF-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0003062
Super-classes obo:IMR_0003085c

GDF-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0003065
Super-classes obo:IMR_0003085c

GDF-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0003069
Super-classes obo:IMR_0003085c

GDF-8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0003073
Super-classes obo:IMR_0000040c

GDF-9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0003077
Super-classes obo:IMR_0000040c

GDF-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0003080
Super-classes obo:IMR_0000040c

BMP-2 subfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0003083
Super-classes obo:IMR_0000040c
Sub-classes obo:IMR_0001424c
obo:IMR_0001428c

BMP-5 subfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0003084
Super-classes obo:IMR_0000040c
Sub-classes obo:IMR_0001431c
obo:IMR_0001432c
obo:IMR_0001429c
obo:IMR_0001430c
obo:IMR_0001433c

GDF-5 subfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0003085
Super-classes obo:IMR_0000040c
Sub-classes obo:IMR_0003065c
obo:IMR_0003069c
obo:IMR_0003062c

nucleoside diphosphate kinasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0010012
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0002046c
obo:IMR_0011416c
obo:IMR_0002044c
obo:IMR_0011415c
obo:IMR_0011423c
obo:IMR_0011414c
obo:IMR_0002049c

NELFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010013
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003644c
Sub-classes obo:IMR_0011350c
obo:IMR_0011351c
obo:IMR_0011352c
obo:IMR_0010453c

eIFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010016
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003685c
Sub-classes obo:IMR_0000902c
obo:IMR_0000904c
obo:IMR_0000903c
obo:IMR_0011152c
obo:IMR_0000913c
obo:IMR_0011158c
obo:TXPO_1000132c
obo:IMR_0000908c
obo:IMR_0000909c
obo:TXPO_1000133c
obo:IMR_0000912c
obo:IMR_0000915c
obo:IMR_0000916c
obo:TXPO_1000421c
obo:IMR_0011159c
obo:IMR_0011160c

Elonginc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010020
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003644c
Sub-classes obo:IMR_0011347c
obo:IMR_0011348c
obo:IMR_0011349c

Heterogeneous nuclear ribonucleoproteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010024
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0010513c
obo:IMR_0010507c
obo:IMR_0010429c
obo:IMR_0010510c
obo:IMR_0010505c
obo:IMR_0010519c
obo:IMR_0010509c
obo:IMR_0010508c
obo:IMR_0010518c
obo:IMR_0010514c
obo:IMR_0010516c
obo:IMR_0010517c
obo:IMR_0010515c
obo:IMR_0010506c
obo:IMR_0010512c
obo:IMR_0010511c

fatty acid synthasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0010252
Description

related molecular function GO:0004312
Super-classes obo:TXPO_0001385c
Sub-classes obo:TXPO_0003326c

Glutathione peroxidasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0010278
Super-classes obo:CHEBI_25367c

GLUT1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010280
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003336c

GLUT2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010281
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003336c

GLUT4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010283
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003336c

Mitochondrial ornithine transporter 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010387
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003697c

Polypyrimidine tract-binding protein 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010429
Super-classes obo:IMR_0010024c

60S ribosomal protein L10ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010443
Super-classes obo:IMR_0000897c

60S ribosomal protein L13ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010444
Super-classes obo:IMR_0000897c

60S ribosomal protein L26-like 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010446
Super-classes obo:IMR_0000897c

40S ribosomal protein S27ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010447
Super-classes obo:IMR_0000896c

60S ribosomal protein L35ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010448
Super-classes obo:IMR_0000897c

60S ribosomal protein L37ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010449
Super-classes obo:IMR_0000897c

NELF-Ec # Classes

URI http://purl.obolibrary.org/obo/IMR_0010453
Super-classes obo:IMR_0010013c

60S ribosomal protein L10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010461
Super-classes obo:IMR_0000897c

60S ribosomal protein L11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010462
Super-classes obo:IMR_0000897c

60S ribosomal protein L12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010463
Super-classes obo:IMR_0000897c

60S ribosomal protein L13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010464
Super-classes obo:IMR_0000897c

60S ribosomal protein L14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010465
Super-classes obo:IMR_0000897c

60S ribosomal protein L15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010466
Super-classes obo:IMR_0000897c

60S ribosomal protein L17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010467
Super-classes obo:IMR_0000897c

60S ribosomal protein L18c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010468
Super-classes obo:IMR_0000897c

60S ribosomal protein L19c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010469
Super-classes obo:IMR_0000897c

60S ribosomal protein L18ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010470
Super-classes obo:IMR_0000897c

60S ribosomal protein L21c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010471
Super-classes obo:IMR_0000897c

60S ribosomal protein L22c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010472
Super-classes obo:IMR_0000897c

60S ribosomal protein L23c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010473
Super-classes obo:IMR_0000897c

60S ribosomal protein L24c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010474
Super-classes obo:IMR_0000897c

60S ribosomal protein L26c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010475
Super-classes obo:IMR_0000897c

60S ribosomal protein L27c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010476
Super-classes obo:IMR_0000897c

60S ribosomal protein L28c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010477
Super-classes obo:IMR_0000897c

60S ribosomal protein L29c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010478
Super-classes obo:IMR_0000897c

60S ribosomal protein L27ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010479
Super-classes obo:IMR_0000897c

60S ribosomal protein L23ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010480
Super-classes obo:IMR_0000897c

60S ribosomal protein L30c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010481
Super-classes obo:IMR_0000897c

60S ribosomal protein L31c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010482
Super-classes obo:IMR_0000897c

60S ribosomal protein L32c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010483
Super-classes obo:IMR_0000897c

60S ribosomal protein L34c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010484
Super-classes obo:IMR_0000897c

60S ribosomal protein L35c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010485
Super-classes obo:IMR_0000897c

60S ribosomal protein L36c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010486
Super-classes obo:IMR_0000897c

60S ribosomal protein L37c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010487
Super-classes obo:IMR_0000897c

60S ribosomal protein L38c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010488
Super-classes obo:IMR_0000897c

60S ribosomal protein L39c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010489
Super-classes obo:IMR_0000897c

60S ribosomal protein L3-likec # Classes

URI http://purl.obolibrary.org/obo/IMR_0010490
Super-classes obo:IMR_0000897c

60S ribosomal protein L3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010491
Super-classes obo:IMR_0000897c

60S ribosomal protein L40c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010492
Super-classes obo:IMR_0000897c

60S ribosomal protein L41c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010493
Super-classes obo:IMR_0000897c

60S ribosomal protein L36ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010494
Super-classes obo:IMR_0000897c

60S ribosomal protein L4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010495
Super-classes obo:IMR_0000897c

60S ribosomal protein L5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010496
Super-classes obo:IMR_0000897c

60S ribosomal protein L6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010497
Super-classes obo:IMR_0000897c

60S ribosomal protein L7ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010498
Super-classes obo:IMR_0000897c

60S ribosomal protein L7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010499
Super-classes obo:IMR_0000897c

60S ribosomal protein L8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010500
Super-classes obo:IMR_0000897c

60S ribosomal protein L9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010501
Super-classes obo:IMR_0000897c

60S acidic ribosomal protein P0c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010502
Super-classes obo:IMR_0000897c

60S acidic ribosomal protein P1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010503
Super-classes obo:IMR_0000897c

60S acidic ribosomal protein P2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010504
Super-classes obo:IMR_0000897c

Heterogeneous nuclear ribonucleoprotein A0c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010505
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein A1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010506
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoproteins A2/B1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010507
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein A3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010508
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoproteins C1/C2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010509
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein D0c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010510
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein Fc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010511
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein Gc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010512
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein Hc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010513
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein H'c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010514
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein Kc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010515
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein Lc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010516
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein Mc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010517
Super-classes obo:IMR_0010024c

Heterogeneous nuclear ribonucleoprotein Rc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010518
Super-classes obo:IMR_0010024c

Heterogenous nuclear ribonucleoprotein Uc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010519
Super-classes obo:IMR_0010024c

40S ribosomal protein S10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010535
Super-classes obo:IMR_0000896c

40S ribosomal protein S11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010536
Super-classes obo:IMR_0000896c

40S ribosomal protein S12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010537
Super-classes obo:IMR_0000896c

40S ribosomal protein S13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010538
Super-classes obo:IMR_0000896c

40S ribosomal protein S14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010539
Super-classes obo:IMR_0000896c

40S ribosomal protein S15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010540
Super-classes obo:IMR_0000896c

40S ribosomal protein S16c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010541
Super-classes obo:IMR_0000896c

40S ribosomal protein S17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010542
Super-classes obo:IMR_0000896c

40S ribosomal protein S18c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010543
Super-classes obo:IMR_0000896c

40S ribosomal protein S19c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010544
Super-classes obo:IMR_0000896c

40S ribosomal protein S15ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010545
Super-classes obo:IMR_0000896c

40S ribosomal protein S20c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010546
Super-classes obo:IMR_0000896c

40S ribosomal protein S21c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010547
Super-classes obo:IMR_0000896c

40S ribosomal protein S23c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010548
Super-classes obo:IMR_0000896c

40S ribosomal protein S24c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010549
Super-classes obo:IMR_0000896c

40S ribosomal protein S25c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010550
Super-classes obo:IMR_0000896c

40S ribosomal protein S26c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010551
Super-classes obo:IMR_0000896c

40S ribosomal protein S27c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010552
Super-classes obo:IMR_0000896c

40S ribosomal protein S28c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010553
Super-classes obo:IMR_0000896c

40S ribosomal protein S29c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010554
Super-classes obo:IMR_0000896c

40S ribosomal protein S2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010555
Super-classes obo:IMR_0000896c

40S ribosomal protein S30c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010556
Super-classes obo:IMR_0000896c

40S ribosomal protein S3ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0010557
Super-classes obo:IMR_0000896c

40S ribosomal protein S3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010558
Super-classes obo:IMR_0000896c

40S ribosomal protein S4, Y isoformc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010559
Super-classes obo:IMR_0000896c

40S ribosomal protein S4, X isoformc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010560
Super-classes obo:IMR_0000896c

40S ribosomal protein S5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010561
Super-classes obo:IMR_0000896c

40S ribosomal protein S7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010563
Super-classes obo:IMR_0000896c

40S ribosomal protein S8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010564
Super-classes obo:IMR_0000896c

40S ribosomal protein S9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0010565
Super-classes obo:IMR_0000896c

40S ribosomal protein SAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010567
Super-classes obo:IMR_0000896c

TFIIS proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010628
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003644c

TFIIBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0010630
Super-classes obo:IMR_0000888c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c

eIF2-alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011133
Super-classes obo:IMR_0000913c

eIF2-betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011134
Super-classes obo:IMR_0000913c

eIF2-gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011135
Super-classes obo:IMR_0000913c

eIF2B-alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011136
Super-classes obo:IMR_0000915c

eIF2B-betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011137
Super-classes obo:IMR_0000915c

eIF2B-deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011138
Super-classes obo:IMR_0000915c

eIF2B-epsilonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011139
Super-classes obo:IMR_0000915c

eIF2B-gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011140
Super-classes obo:IMR_0000915c

eIF3jc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011141
Super-classes obo:IMR_0000916c

eIF3ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0011142
Super-classes obo:IMR_0000916c

eIF3gc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011143
Super-classes obo:IMR_0000916c

eIF3fc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011144
Super-classes obo:IMR_0000916c

eIF3bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011145
Super-classes obo:IMR_0000916c

eIF3hc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011146
Super-classes obo:IMR_0000916c

eIF3ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011147
Super-classes obo:IMR_0000916c

eIF3dc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011148
Super-classes obo:IMR_0000916c

eIF3cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011149
Super-classes obo:IMR_0000916c

eIF3ec # Classes

URI http://purl.obolibrary.org/obo/IMR_0011150
Super-classes obo:IMR_0000916c

eIF3kc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011151
Super-classes obo:IMR_0000916c

eIF1Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0011152
Super-classes obo:IMR_0010016c

eIF4A-Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0011153
Super-classes obo:IMR_0000906c

eIF4A-IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011154
Super-classes obo:IMR_0000906c

eIF4Ec # Classes

URI http://purl.obolibrary.org/obo/IMR_0011155
Super-classes obo:IMR_0000912c

eIF4GIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011157
Super-classes obo:IMR_0000910c

eIF4Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011158
Super-classes obo:IMR_0010016c

eIF4Hc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011159
Super-classes obo:IMR_0010016c

eIF5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0011160
Super-classes obo:IMR_0010016c

Elongin A1 proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011347
Super-classes obo:IMR_0010020c

Elongin B proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011348
Super-classes obo:IMR_0010020c

Elongin C proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011349
Super-classes obo:IMR_0010020c

NELF-A proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011350
Super-classes obo:IMR_0010013c

NELF-B proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011351
Super-classes obo:IMR_0010013c

NELF-C/D proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011352
Super-classes obo:IMR_0010013c

NDKAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011414
Super-classes obo:IMR_0010012c

NDKBc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011415
Super-classes obo:IMR_0010012c

NDK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0011416
Super-classes obo:IMR_0010012c

NDKMc # Classes

URI http://purl.obolibrary.org/obo/IMR_0011423
Super-classes obo:IMR_0010012c

cGMP phosphodiesterasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100002
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003672c
Sub-classes obo:IMR_0001028c
obo:IMR_0001023c
obo:IMR_0001026c
obo:IMR_0001024c
obo:IMR_0001025c
obo:IMR_0001027c
obo:IMR_0001029c
obo:IMR_0001022c

importinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100010
Super-classes obo:IMR_0001091c
Sub-classes obo:IMR_0001112c
obo:IMR_0100203c
obo:IMR_0001102c
obo:IMR_0001111c
obo:IMR_0001105c
obo:IMR_0001096c
obo:IMR_0001103c
obo:IMR_0001108c
obo:IMR_0100202c
obo:IMR_0001097c
obo:IMR_0001101c
obo:IMR_0001113c

exportinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100015
Super-classes obo:IMR_0001091c
Sub-classes obo:IMR_0001105c
obo:IMR_0001100c
obo:IMR_0001099c
obo:IMR_0100204c
obo:IMR_0001098c
obo:IMR_0001090c
obo:IMR_0001114c

prostaglandinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100019
Super-classes obo:CHEBI_26347c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c
obo:RO_0000087op some obo:TXPO_0003686c
Sub-classes obo:IMR_0200497c
obo:IMR_0200281c
obo:IMR_0200457c
obo:IMR_0200253c
obo:IMR_0200146c
obo:TXPO_0002702c
obo:IMR_0200051c

leukotrienec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100021
Super-classes obo:CHEBI_23899c
Restrictions obo:RO_0000087op some obo:TXPO_0003686c
obo:RO_0000087op some obo:TXPO_0002401c

cAMPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100024
Super-classes obo:IMR_0001355c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c

cGMPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100025
Super-classes obo:IMR_0001355c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c

diacylglycerolc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100027
Super-classes obo:CHEBI_35741c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c

IP3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100028
Super-classes obo:IMR_0001385c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c

IP4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100029
Super-classes obo:IMR_0001385c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c

steroid hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100033
Super-classes obo:IMR_0000966c
Sub-classes obo:IMR_0100037c
obo:IMR_0100034c
obo:IMR_0100036c

progesteronec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100034
Super-classes obo:IMR_0100033c

glucocorticoidc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100036
Super-classes obo:IMR_0100033c

mineralocorticoidc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100037
Super-classes obo:IMR_0100033c
Sub-classes obo:IMR_0002120c

vitamin Dc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100040
Super-classes obo:IMR_0000877c

retinoic acidc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100041
Super-classes obo:IMR_0000877c

thyroid hormone (substance)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100042
Super-classes obo:IMR_0000966c
Sub-classes obo:IMR_0100044c
obo:IMR_0100043c

thyroxinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100043
Super-classes obo:CHEBI_33709c
obo:IMR_0100042c

triiodothyroninec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100044
Super-classes obo:IMR_0100042c
obo:CHEBI_33709c

calcitoninc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100045
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c

cholecystokininc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100048
Super-classes obo:IMR_0100072c

gastric inhibitory polypeptidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100050
Super-classes obo:IMR_0100072c

motilinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100051
Super-classes obo:IMR_0100072c

prolactin-releasing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100055
Super-classes obo:IMR_0100093c

thyrotropin-releasing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100056
Super-classes obo:IMR_0100093c

growth hormone-releasing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100057
Super-classes obo:IMR_0100093c

MSH-releasing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100058
Super-classes obo:IMR_0100093c

beta-MSHc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100064
Super-classes obo:IMR_0100198c

melatoninc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100069
Super-classes obo:IMR_0002121c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c

gastrin-releasing peptidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100070
Super-classes obo:IMR_0100072c

vasoactive intestinal peptidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100071
Super-classes obo:IMR_0100072c

gastrointestinal hormonesc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100072
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100050c
obo:IMR_0100070c
obo:IMR_0100074c
obo:IMR_0100075c
obo:IMR_0100211c
obo:IMR_0100071c
obo:IMR_0100048c
obo:IMR_0100051c

peptide YYc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100074
Super-classes obo:IMR_0100072c

secretinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100075
Super-classes obo:IMR_0100072c

pancreatic hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100076
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100212c
obo:IMR_0100213c
obo:IMR_0100077c

glucagonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100077
Super-classes obo:IMR_0100076c

hypothalamic hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100082
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100093c
obo:IMR_0100090c

parathyroid hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100083
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c

pituitary hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100084
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100198c
obo:IMR_0100096c
obo:IMR_0100103c

placental hormone, peptidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100086
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100106c
obo:IMR_0100105c

gonadotropinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100087
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100106c
obo:IMR_0100098c

thymus hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100089
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100110c
obo:IMR_0100109c
obo:IMR_0100108c

pituitary hormone release inhibiting hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100090
Super-classes obo:IMR_0100082c
Sub-classes obo:IMR_0100091c
obo:IMR_0100092c
obo:IMR_0100213c

MSH release-inhibiting hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100091
Super-classes obo:IMR_0100090c

prolactin release-inhibiting hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100092
Super-classes obo:IMR_0100090c

pituitary hormone-releasing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100093
Super-classes obo:IMR_0100082c
Sub-classes obo:IMR_0100094c
obo:IMR_0100058c
obo:IMR_0100056c
obo:IMR_0100055c
obo:IMR_0100057c
obo:IMR_0100095c

corticotropin-releasing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100094
Super-classes obo:IMR_0100093c

gonadotropin-releasing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100095
Super-classes obo:IMR_0100093c

pituitary hormone, anteriorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100096
Super-classes obo:IMR_0100084c
Sub-classes obo:IMR_0100098c
obo:IMR_0100102c
obo:IMR_0100195c
obo:IMR_0100197c
obo:IMR_0100200c

glycoprotein hormone, alpha subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100097
Super-classes obo:IMR_0100200c
obo:IMR_0100100c
obo:IMR_0100106c
obo:IMR_0100099c

gonadotropin, pituitaryc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100098
Super-classes obo:IMR_0100087c
obo:IMR_0100096c
Sub-classes obo:IMR_0100100c
obo:IMR_0100099c
obo:IMR_0100194c

follicle stimulating hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100099
Super-classes obo:IMR_0100098c
Sub-classes obo:IMR_0100097c

luteinizing hormonec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100100
Super-classes obo:IMR_0100098c
Sub-classes obo:IMR_0100097c

growth hormone (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100102
Super-classes obo:IMR_0100096c

pituitary hormone, posteriorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100103
Super-classes obo:IMR_0100084c
Sub-classes obo:IMR_0100104c
obo:IMR_0100201c

oxytocinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100104
Super-classes obo:IMR_0100103c

placental lactogenc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100105
Super-classes obo:IMR_0100086c

chorionic gonadotropinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100106
Super-classes obo:IMR_0100086c
obo:IMR_0100087c
Sub-classes obo:IMR_0100097c

thymic factor, circulatingc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100108
Super-classes obo:IMR_0100089c

thymopoietinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100109
Super-classes obo:IMR_0100089c

thymosinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100110
Super-classes obo:IMR_0100089c

acetylcholinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100111
Super-classes obo:IMR_0002121c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

dopaminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100113
Super-classes obo:IMR_0001694c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

adrenalinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100114
Super-classes obo:IMR_0001694c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

noradrenalinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100115
Super-classes obo:IMR_0001694c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

gamma-aminobutyric acidc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100117
Super-classes obo:CHEBI_33709c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

glycinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100118
Super-classes obo:CHEBI_33709c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

glutamic acidc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100119
Super-classes obo:CHEBI_33709c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

taurinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100120
Super-classes obo:CHEBI_33709c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

octopaminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100122
Super-classes obo:IMR_0002121c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

serotoninc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100123
Super-classes obo:IMR_0002121c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
obo:RO_0000087op some obo:CHEBI_25512c

tyraminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100124
Super-classes obo:IMR_0002121c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

histaminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100125
Super-classes obo:IMR_0002121c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

angiotensin Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0100131
Super-classes obo:IMR_0100149c

angiotensin IIIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100132
Super-classes obo:IMR_0100149c

beta-endorphinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100135
Super-classes obo:IMR_0100154c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c

bradykininc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100137
Super-classes obo:IMR_0100165c

kallidinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100138
Super-classes obo:IMR_0100165c

somatomedinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100143
Super-classes obo:IMR_0000966c
Restrictions obo:RO_0000087op some obo:CHEBI_24621c
Sub-classes obo:IMR_0100144c
obo:IMR_0100145c

insulin-like growth factor Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0100144
Super-classes obo:IMR_0100143c
obo:IMR_0002835c

insulin-like growth factor IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100145
Super-classes obo:IMR_0002835c
obo:IMR_0100143c

angiotensinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100149
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c
Sub-classes obo:IMR_0100132c
obo:IMR_0100131c
obo:IMR_0100150c

angiotensin IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100150
Super-classes obo:IMR_0100149c

opioid peptidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100153
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c
Sub-classes obo:IMR_0100154c
obo:IMR_0100157c

endorphinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100154
Super-classes obo:IMR_0100153c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c
Sub-classes obo:IMR_0100135c
obo:IMR_0100155c
obo:IMR_0100156c

alpha-endorphinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100155
Super-classes obo:IMR_0100154c

gamma-endorphinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100156
Super-classes obo:IMR_0100154c

enkephalinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100157
Super-classes obo:IMR_0100153c
Restrictions obo:RO_0000087op some obo:CHEBI_25512c
Sub-classes obo:IMR_0100158c
obo:IMR_0100159c
obo:IMR_0100160c
obo:IMR_0100161c

leucine enkephalinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100158
Super-classes obo:IMR_0100157c

adrenorphinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100159
Super-classes obo:IMR_0100157c

alpha-neoendorphinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100160
Super-classes obo:IMR_0100157c

rimorphinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100161
Super-classes obo:IMR_0100157c

kininc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100165
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0100138c
obo:IMR_0002126c
obo:IMR_0100137c

endothelinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100166
Description

21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0100169c
obo:IMR_0100168c
obo:IMR_0100167c

endothelin-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100167
Super-classes obo:IMR_0100166c

endothelin-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100168
Super-classes obo:IMR_0100166c

endothelin-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100169
Super-classes obo:IMR_0100166c

kinesin superfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100192
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003690c
obo:RO_0000087op some obo:TXPO_0000186c
Sub-classes obo:IMR_0100193c
obo:IMR_0000199c

kinesin-like proteinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100193
Super-classes obo:IMR_0100192c
Sub-classes obo:IMR_0003014c

prolactinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100194
Super-classes obo:IMR_0100098c

corticotropinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100195
Super-classes obo:IMR_0100096c

alpha-MSHc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100196
Super-classes obo:IMR_0100198c

lipotropinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100197
Super-classes obo:IMR_0100096c
Sub-classes obo:IMR_0002346c
obo:IMR_0002345c

MSHc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100198
Super-classes obo:IMR_0100084c
Sub-classes obo:IMR_0100196c
obo:IMR_0100064c
obo:IMR_0100199c

gamma-MSHc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100199
Super-classes obo:IMR_0100198c

thyrotropinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100200
Super-classes obo:IMR_0100096c
Sub-classes obo:IMR_0100097c

vasopressinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100201
Super-classes obo:IMR_0100103c

importin alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100202
Super-classes obo:IMR_0100010c
Sub-classes obo:IMR_0001084c
obo:IMR_0001089c
obo:IMR_0001085c
obo:IMR_0001088c
obo:IMR_0001086c
obo:IMR_0001087c

importin betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100203
Super-classes obo:IMR_0100010c

CAS/CSEc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100204
Super-classes obo:IMR_0100015c

RCC1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100205
Super-classes obo:IMR_0000433c

Ran GAPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100206
Super-classes obo:IMR_0000442c

MAPKKKKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100207
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0000252c

gastrinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100211
Super-classes obo:IMR_0100072c

pancreatic polypeptidec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100212
Super-classes obo:IMR_0100076c

somatostatinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100213
Super-classes obo:IMR_0100076c
obo:IMR_0100090c

ERK5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100216
Super-classes obo:IMR_0000224c

ASK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100218
Super-classes obo:IMR_0000229c

TAO1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100219
Super-classes obo:IMR_0000229c

ASK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100221
Super-classes obo:IMR_0000229c

MEKK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100222
Super-classes obo:IMR_0000234c

MEK5(MKK5)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100224
Super-classes obo:IMR_0000259c

ZAKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100248
Super-classes obo:IMR_0000239c

MLKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100249
Super-classes obo:IMR_0000239c
Sub-classes obo:IMR_0100253c
obo:IMR_0100250c
obo:IMR_0100252c
obo:IMR_0100251c

MLK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100250
Super-classes obo:IMR_0100249c

MLK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100251
Super-classes obo:IMR_0100249c

MLK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100252
Super-classes obo:IMR_0100249c

MLK4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100253
Super-classes obo:IMR_0100249c

DLKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100254
Super-classes obo:IMR_0000239c
Sub-classes obo:IMR_0100255c
obo:IMR_0100256c

DLK familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100255
Super-classes obo:IMR_0100254c

LZKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100256
Super-classes obo:IMR_0100254c

SLP-76 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100258
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003684c
Sub-classes obo:IMR_0000353c
obo:IMR_0000350c

MAPKAPK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100266
Super-classes obo:IMR_0001689c

MAPKAPK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100267
Super-classes obo:IMR_0001689c

Rho GAPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100268
Super-classes obo:IMR_0000442c

Rab GAPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100269
Super-classes obo:IMR_0000442c

Arf GAPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100270
Super-classes obo:IMR_0000442c

MAPKAPKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100271
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100273c
obo:IMR_0100272c
obo:IMR_0000248c
obo:IMR_0001689c

MAPKAPK5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100272
Super-classes obo:IMR_0100271c

MNKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100273
Super-classes obo:IMR_0100271c
Sub-classes obo:IMR_0001690c
obo:IMR_0001691c

amphiregulinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100274
Super-classes obo:IMR_0000047c

betacellulinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100275
Super-classes obo:IMR_0000047c

epiregulinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100276
Super-classes obo:IMR_0000047c

HB-EGFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100277
Super-classes obo:IMR_0000047c

TGF-alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100278
Super-classes obo:IMR_0000047c

EGF (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100279
Super-classes obo:IMR_0000047c

I-kappaB alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100280
Super-classes obo:IMR_0000464c

I-kappaB betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100281
Super-classes obo:IMR_0000464c

I-kappaB epsilonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100282
Super-classes obo:IMR_0000464c

Bad (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100288
Super-classes obo:IMR_0100709c
Sub-classes obo:TXPO_0001097c
obo:TXPO_0003197c
obo:TXPO_0000866c

Bid (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100289
Super-classes obo:IMR_0100709c
Sub-classes obo:TXPO_0004357c
obo:TXPO_0003199c
obo:TXPO_0001093c

Bikc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100290
Super-classes obo:IMR_0100709c

BIM (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100291
Super-classes obo:IMR_0100709c
Sub-classes obo:TXPO_0002955c

Bfl-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100292
Super-classes obo:IMR_0100706c

Bcl-xLc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100293
Super-classes obo:IMR_0100706c

caspase-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100297
Super-classes obo:IMR_0000306c

caspase-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100298
Super-classes obo:IMR_0000306c

caspase-9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100299
Super-classes obo:IMR_0000306c

caspase-8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100300
Super-classes obo:IMR_0000308c

caspase-10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100301
Super-classes obo:IMR_0000308c

caspase-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100302
Super-classes obo:IMR_0000305c
Sub-classes obo:TXPO_0001104c
obo:TXPO_0003826c
obo:TXPO_0000894c
obo:TXPO_0001079c

caspase-2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100303
Super-classes obo:IMR_0000308c
Sub-classes obo:TXPO_0003272c

caspase-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100304
Super-classes obo:IMR_0000305c

caspase-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100305
Super-classes obo:IMR_0000305c

caspase-11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100306
Super-classes obo:IMR_0000305c

caspase-12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100307
Super-classes obo:IMR_0000305c

caspase-14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100308
Super-classes obo:IMR_0000305c

caspase-13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100309
Super-classes obo:IMR_0000305c

Smad1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100310
Super-classes obo:IMR_0100507c

Smad2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100311
Super-classes obo:IMR_0100504c

Smad3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100312
Super-classes obo:IMR_0100504c

Smad5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100313
Super-classes obo:IMR_0100507c

Smad8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100314
Super-classes obo:IMR_0100507c

Smad4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100315
Super-classes obo:IMR_0000372c

Smad6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100317
Super-classes obo:IMR_0000373c

Smad7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100318
Super-classes obo:IMR_0000373c

JAK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100319
Super-classes obo:IMR_0000213c

JAK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100320
Super-classes obo:IMR_0000213c

JAK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100321
Super-classes obo:IMR_0000213c

Tyk2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100322
Super-classes obo:IMR_0000213c

IFNGR-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100323
Super-classes obo:IMR_0000136c

IFNGR-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100324
Super-classes obo:IMR_0000136c

NAIPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100328
Super-classes obo:IMR_0000454c

c-IAP1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100329
Super-classes obo:IMR_0000454c

c-IAP2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100330
Super-classes obo:IMR_0000454c

XIAPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100331
Super-classes obo:IMR_0000454c

Survivinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100332
Super-classes obo:IMR_0000454c

RasGRF1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100347
Super-classes obo:IMR_0000440c

RasGRF2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100348
Super-classes obo:IMR_0000440c

RasGRPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100349
Super-classes obo:IMR_0100440c

TCR alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100350
Super-classes obo:IMR_0000151c

TCR betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100351
Super-classes obo:IMR_0000151c

Fync # Classes

URI http://purl.obolibrary.org/obo/IMR_0100352
Super-classes obo:IMR_0000211c

Lckc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100353
Super-classes obo:IMR_0000211c

Raf-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100355
Super-classes obo:IMR_0000231c

PAK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100356
Super-classes obo:IMR_0000238c

Cbl-bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100363
Super-classes obo:IMR_0000356c

Cbl-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100364
Super-classes obo:IMR_0000356c

G-alpha-sc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100366
Super-classes obo:IMR_0000317c

G-alpha-olfc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100367
Super-classes obo:IMR_0000317c

G-alpha-i 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100368
Super-classes obo:IMR_0000319c

G-alpha-i 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100369
Super-classes obo:IMR_0000319c

G-alpha-i 3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100370
Super-classes obo:IMR_0000319c

G-alpha-t 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100373
Super-classes obo:IMR_0000321c

G-alpha-t 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100374
Super-classes obo:IMR_0000321c

G-alpha-11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100375
Super-classes obo:IMR_0000323c

G-alpha-14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100376
Super-classes obo:IMR_0000323c

G-alpha-15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100377
Super-classes obo:IMR_0000323c

G-alpha-qc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100378
Super-classes obo:IMR_0000323c

G-alpha-Yc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100379
Super-classes obo:IMR_0000323c

G-alpha-12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100380
Super-classes obo:IMR_0000324c

G-alpha-13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100381
Super-classes obo:IMR_0000324c

Grb7/10/14 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100382
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003657c
Sub-classes obo:IMR_0000357c
obo:IMR_0000737c
obo:IMR_0000736c

Cip1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100383
Super-classes obo:IMR_0000446c

p27Kip1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100384
Super-classes obo:IMR_0000446c

p57KIP2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100385
Super-classes obo:IMR_0000446c

IFN alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100386
Super-classes obo:IMR_0000028c
Sub-classes obo:IMR_0000576c
obo:IMR_0000581c
obo:IMR_0000582c
obo:IMR_0000584c
obo:IMR_0000575c
obo:IMR_0000578c
obo:IMR_0000580c
obo:IMR_0000573c
obo:IMR_0000577c
obo:IMR_0000579c
obo:IMR_0000583c
obo:IMR_0000574c
obo:IMR_0000572c

IFN omegac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100387
Super-classes obo:IMR_0000028c

IFN betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100388
Super-classes obo:IMR_0000028c

IFN deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100389
Super-classes obo:IMR_0000028c

IFN gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100390
Super-classes obo:IMR_0000029c

IFNAR-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100391
Super-classes obo:IMR_0000135c

IFNAR-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100392
Super-classes obo:IMR_0000135c

IRS-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100393
Super-classes obo:IMR_0000351c

IRS-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100394
Super-classes obo:IMR_0000351c

IRS-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100395
Super-classes obo:IMR_0000351c

IRS-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100396
Super-classes obo:IMR_0000351c

NGFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100407
Super-classes obo:IMR_0000034c

BDNFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100408
Super-classes obo:IMR_0000034c

NT-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100409
Super-classes obo:IMR_0000034c

NT-4/5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100410
Super-classes obo:IMR_0000034c

TR alpha 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100418
Super-classes obo:IMR_0000086c

TR alpha 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100419
Super-classes obo:IMR_0000086c

TR beta 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100420
Super-classes obo:IMR_0000086c

TR beta 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100421
Super-classes obo:IMR_0000086c

TRAF1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100422
Super-classes obo:IMR_0000462c

TRAF2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100423
Super-classes obo:IMR_0000462c
Sub-classes obo:TXPO_0002818c

TRAF3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100424
Super-classes obo:IMR_0000462c
Sub-classes obo:TXPO_0003206c

TRAF4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100425
Super-classes obo:IMR_0000462c

TRAF5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100426
Super-classes obo:IMR_0000462c

TRAF6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100427
Super-classes obo:IMR_0000462c

GAP1mc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100428
Super-classes obo:IMR_0000443c

GAP1(IP4BP)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100429
Super-classes obo:IMR_0000443c

NF-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100430
Super-classes obo:IMR_0000443c

RasGAPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100431
Super-classes obo:IMR_0000443c

RalGDSc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100433
Super-classes obo:IMR_0000439c

RasGEFc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100440
Super-classes obo:IMR_0000433c
Sub-classes obo:IMR_0001976c
obo:IMR_0000439c
obo:IMR_0000435c
obo:IMR_0000436c
obo:IMR_0100349c
obo:IMR_0000440c

RelAc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100446
Super-classes obo:IMR_0000382c

p50c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100447
Super-classes obo:IMR_0000382c

ERK1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100448
Super-classes obo:IMR_0000227c

ERK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100449
Super-classes obo:IMR_0000227c

MEKK2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100450
Super-classes obo:IMR_0000234c

MEKK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100451
Super-classes obo:IMR_0000234c

MEK1(MKK1)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100452
Super-classes obo:IMR_0000261c

MEK2(MKK2)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100453
Super-classes obo:IMR_0000261c

MKK4(JNKK1)(SEK1)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100454
Super-classes obo:IMR_0000262c

MKK7(JNKK2)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100455
Super-classes obo:IMR_0000262c

MKK3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100456
Super-classes obo:IMR_0000263c

MKK6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100457
Super-classes obo:IMR_0000263c

IKK alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100458
Super-classes obo:IMR_0000701c

IKK betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100459
Super-classes obo:IMR_0000701c

IKK gammac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100460
Super-classes obo:IMR_0000701c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c

IKK epsilonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100461
Super-classes obo:IMR_0000701c

FADDc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100463
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003682c

TRADD (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100464
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003682c
Sub-classes obo:TXPO_0003203c

MyD88c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100465
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003682c

CRADDc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100466
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003682c

SCF ubiquitin ligase complexc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100470
Super-classes obo:TXPO_0002107c
Restrictions obo:RO_0000087op some obo:TXPO_0000266c

PKC thetac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100484
Super-classes obo:IMR_0000246c

cPKCc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100486
Super-classes obo:IMR_0000245c
Sub-classes obo:IMR_0001146c
obo:IMR_0001145c
obo:IMR_0001147c

IRAKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100488
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0000890c
obo:IMR_0000892c
obo:IMR_0000891c

Smad2/3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100504
Super-classes obo:IMR_0000371c
Sub-classes obo:IMR_0100312c
obo:IMR_0100311c

Smad1/5/8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100507
Super-classes obo:IMR_0000371c
Sub-classes obo:IMR_0100313c
obo:IMR_0100314c
obo:IMR_0100310c

Smurfc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100512
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000266c
Sub-classes obo:IMR_0100514c
obo:IMR_0100513c

Smurf1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100513
Super-classes obo:IMR_0100512c

Smurf2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100514
Super-classes obo:IMR_0100512c

GCK familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100535
Super-classes obo:IMR_0000253c
Sub-classes obo:IMR_0100536c
obo:IMR_0100538c
obo:IMR_0100537c

GCKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100536
Super-classes obo:IMR_0100535c

GCKRc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100537
Super-classes obo:IMR_0100535c

GLKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100538
Super-classes obo:IMR_0100535c

p62c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100540
Super-classes obo:CHEBI_25367c

CaMKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100543
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100548c

CaM-kinase IIc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100548
Super-classes obo:IMR_0100543c

PDGF A-chainc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100549
Super-classes obo:IMR_0000032c

PDGF B-chainc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100550
Super-classes obo:IMR_0000032c

FGF-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100551
Super-classes obo:IMR_0000049c

FGF-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100552
Super-classes obo:IMR_0000049c

FGF-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100553
Super-classes obo:IMR_0000049c

FGF-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100554
Super-classes obo:IMR_0000049c

FGF-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100555
Super-classes obo:IMR_0000049c

FGF-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100556
Super-classes obo:IMR_0000049c

FGF-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100557
Super-classes obo:IMR_0000049c

FGF-8c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100558
Super-classes obo:IMR_0000049c

FGF-9c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100559
Super-classes obo:IMR_0000049c

FGF-10c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100560
Super-classes obo:IMR_0000049c

FGF-11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100561
Super-classes obo:IMR_0000049c

FGF-12c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100562
Super-classes obo:IMR_0000049c

FGF-13c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100563
Super-classes obo:IMR_0000049c

FGF-14c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100564
Super-classes obo:IMR_0000049c

FGF-15c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100565
Super-classes obo:IMR_0000049c

FGF-16c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100566
Super-classes obo:IMR_0000049c

FGF-17c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100567
Super-classes obo:IMR_0000049c

FGF-18c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100568
Super-classes obo:IMR_0000049c

FGF-19c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100569
Super-classes obo:IMR_0000049c

FGF-20c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100570
Super-classes obo:IMR_0000049c

FGF-21c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100571
Super-classes obo:IMR_0000049c

FGF-22c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100572
Super-classes obo:IMR_0000049c

FGF-23c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100573
Super-classes obo:IMR_0000049c

Src (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100575
Super-classes obo:IMR_0000211c
Sub-classes obo:TXPO_0004876c
obo:TXPO_0004951c

syndecanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100579
Super-classes obo:IMR_0001125c
Sub-classes obo:IMR_0100583c
obo:IMR_0100581c
obo:IMR_0100582c
obo:IMR_0100580c

syndecan-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100580
Super-classes obo:IMR_0100579c

syndecan-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100581
Super-classes obo:IMR_0100579c

syndecan-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100582
Super-classes obo:IMR_0100579c

syndecan-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100583
Super-classes obo:IMR_0100579c

PI3-kinase p85-alpha subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100589
Super-classes obo:IMR_0000266c

PI3-kinase p85-beta subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100590
Super-classes obo:IMR_0000266c

PI3-kinase p110 subunit alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100592
Super-classes obo:IMR_0000267c

PI3-kinase p110 subunit betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100593
Super-classes obo:IMR_0000267c

PI3-kinase p110 subunit deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100594
Super-classes obo:IMR_0000267c

Cdc2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100597
Super-classes obo:TXPO_0003241c

CDK2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100598
Super-classes obo:TXPO_0003241c
Sub-classes obo:TXPO_0004465c

CDK3(mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100599
Super-classes obo:TXPO_0003241c

CDK5(mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100601
Super-classes obo:TXPO_0003241c

CDK6(mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100602
Super-classes obo:TXPO_0003241c

CDK7(mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100603
Super-classes obo:TXPO_0003241c

CDK8(mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100604
Super-classes obo:TXPO_0003241c

CDK9(mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100605
Super-classes obo:TXPO_0003241c

cyclinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100606
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c
Sub-classes obo:IMR_0100626c
obo:IMR_0100672c
obo:IMR_0100628c
obo:IMR_0100622c
obo:IMR_0100621c
obo:IMR_0100627c
obo:IMR_0100613c
obo:IMR_0100673c
obo:IMR_0100625c
obo:IMR_0100670c
obo:IMR_0100671c

cyclin Ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100607
Super-classes obo:IMR_0100672c
Sub-classes obo:IMR_0100609c
obo:IMR_0100608c

cyclin A1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100608
Super-classes obo:IMR_0100607c

cyclin A2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100609
Super-classes obo:IMR_0100607c

cyclin Bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100610
Super-classes obo:IMR_0100673c
Sub-classes obo:IMR_0100611c
obo:IMR_0100612c

cyclin B1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100611
Super-classes obo:IMR_0100610c
Sub-classes obo:TXPO_0004227c

cyclin B2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100612
Super-classes obo:IMR_0100610c

cyclin Cc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100613
Super-classes obo:IMR_0100606c

cyclin Dc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100614
Super-classes obo:IMR_0100670c
Sub-classes obo:IMR_0100615c
obo:TXPO_1000088c
obo:IMR_0100617c
obo:IMR_0100616c

cyclin D1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100615
Super-classes obo:IMR_0100614c

cyclin D2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100616
Super-classes obo:IMR_0100614c

cyclin D3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100617
Super-classes obo:IMR_0100614c

cyclin Ec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100618
Super-classes obo:IMR_0100671c
Sub-classes obo:IMR_0100619c
obo:IMR_0100620c

cyclin E1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100619
Super-classes obo:IMR_0100618c

cyclin E2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100620
Super-classes obo:IMR_0100618c

cyclin Fc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100621
Super-classes obo:IMR_0100606c

cyclin Gc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100622
Super-classes obo:IMR_0100606c
Sub-classes obo:IMR_0100624c
obo:IMR_0100623c

cyclin G1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100623
Super-classes obo:IMR_0100622c

cyclin G2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100624
Super-classes obo:IMR_0100622c

cyclin Hc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100625
Super-classes obo:IMR_0100606c

cyclin Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0100626
Super-classes obo:IMR_0100606c

cyclin Tc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100628
Super-classes obo:IMR_0100606c
Sub-classes obo:IMR_0100629c
obo:IMR_0100630c

cyclin T1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100629
Super-classes obo:IMR_0100628c

cyclin T2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100630
Super-classes obo:IMR_0100628c

CAKc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100636
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c

Sic1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100645
Super-classes obo:IMR_0000445c

separasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100648
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000304c

p53 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100659
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:TXPO_0005049c
obo:TXPO_0003202c
obo:TXPO_0001801c
obo:TXPO_0000843c
obo:TXPO_0004889c

Mdm2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100660
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000266c
Sub-classes obo:TXPO_0000000c
obo:TXPO_0001932c
obo:TXPO_0000845c
obo:TXPO_0001004c

Cln1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100661
Super-classes obo:IMR_0100671c

Cln2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100662
Super-classes obo:IMR_0100671c

Cln3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100663
Super-classes obo:IMR_0100670c

Clb1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100664
Super-classes obo:IMR_0100673c

Clb2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100665
Super-classes obo:IMR_0100673c

Clb3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100666
Super-classes obo:IMR_0100673c

Clb4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100667
Super-classes obo:IMR_0100673c

Clb5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100668
Super-classes obo:IMR_0100672c

Clb6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100669
Super-classes obo:IMR_0100672c

G1-cyclinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100670
Super-classes obo:IMR_0100606c
Sub-classes obo:IMR_0100614c
obo:IMR_0100663c

G1/S-cyclinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100671
Super-classes obo:IMR_0100606c
Sub-classes obo:IMR_0100618c
obo:IMR_0100662c
obo:IMR_0100661c

S-cyclinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100672
Super-classes obo:IMR_0100606c
Sub-classes obo:IMR_0100669c
obo:IMR_0100607c
obo:IMR_0100668c

M-cyclinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100673
Super-classes obo:IMR_0100606c
Sub-classes obo:IMR_0100667c
obo:IMR_0100664c
obo:IMR_0100610c
obo:IMR_0100666c
obo:IMR_0100665c

TNF alpha receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100674
Super-classes obo:IMR_0000056c
Sub-classes obo:IMR_0000061c
obo:IMR_0000060c

IGF-1 receptorc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100677
Super-classes obo:IMR_0000075c

IP2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100698
Super-classes obo:IMR_0001385c
Restrictions obo:RO_0000087op some obo:TXPO_0002401c

cAMP phosphodiesterasec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100700
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003672c
Sub-classes obo:IMR_0001019c
obo:IMR_0001021c
obo:IMR_0001017c
obo:IMR_0001020c
obo:IMR_0001018c
obo:IMR_0001016c

PTENc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100701
Super-classes obo:CHEBI_25367c

PKA regulatory subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100702
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003722c
Sub-classes obo:IMR_0100848c
obo:IMR_0100850c
obo:IMR_0100849c
obo:IMR_0100847c

PKA catalytic subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100703
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100852c
obo:IMR_0100851c
obo:IMR_0100853c

thrombinc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100704
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:IMR_0000304c

anti-apoptotic Bcl-2 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100705
Super-classes obo:IMR_0000451c
Sub-classes obo:IMR_0100706c

Bcl-2 subfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100706
Super-classes obo:IMR_0100705c
Sub-classes obo:IMR_0100293c
obo:IMR_0100292c
obo:TXPO_1000041c

pro-apoptotic Bcl-2 familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100707
Super-classes obo:IMR_0000451c
Sub-classes obo:IMR_0100708c
obo:IMR_0100709c

Bax subfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100708
Super-classes obo:IMR_0100707c
Sub-classes obo:IMR_0000453c
obo:IMR_0000452c

BH3 subfamilyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100709
Super-classes obo:IMR_0100707c
Sub-classes obo:IMR_0001211c
obo:IMR_0100289c
obo:IMR_0001208c
obo:IMR_0100290c
obo:IMR_0001210c
obo:IMR_0100288c
obo:IMR_0100291c

40S ribosomal protein S6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100711
Super-classes obo:IMR_0000896c

Notchc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100712
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:IMR_0100715c
obo:IMR_0100717c
obo:IMR_0100716c
obo:IMR_0100714c

Notch 1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100714
Super-classes obo:IMR_0100712c
Sub-classes obo:TXPO_0004725c

Notch 2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100715
Super-classes obo:IMR_0100712c
Sub-classes obo:TXPO_0004726c

Notch 3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100716
Super-classes obo:IMR_0100712c
Sub-classes obo:TXPO_0004727c

Notch 4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100717
Super-classes obo:IMR_0100712c

Deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100718
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0100721c
obo:IMR_0100722c
obo:IMR_0100720c

Delta-like1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100720
Super-classes obo:IMR_0100718c

Delta-like3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100721
Super-classes obo:IMR_0100718c

Delta-like4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100722
Super-classes obo:IMR_0100718c

presenilin 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100731
Super-classes obo:IMR_0000560c

presenilin 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100732
Super-classes obo:IMR_0000560c

STAT5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100733
Super-classes obo:IMR_0000374c
Sub-classes obo:IMR_0000379c
obo:IMR_0000380c

GSK-3 alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100736
Super-classes obo:IMR_0000257c

DHH (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100738
Super-classes obo:IMR_0000004c

IHH (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100739
Super-classes obo:IMR_0000004c
Sub-classes obo:TXPO_0004631c

LEF-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100744
Super-classes obo:IMR_0000418c

TCF-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100745
Super-classes obo:IMR_0000418c

TCF-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100746
Super-classes obo:IMR_0000418c

TCF-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100747
Super-classes obo:IMR_0000418c

Dsh familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100755
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0100758c
obo:IMR_0100760c
obo:IMR_0100757c
obo:IMR_0100759c

Dvl-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100757
Super-classes obo:IMR_0100755c

Dvl-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100758
Super-classes obo:IMR_0100755c

Dvl-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100759
Super-classes obo:IMR_0100755c

Dvl-1-likec # Classes

URI http://purl.obolibrary.org/obo/IMR_0100760
Super-classes obo:IMR_0100755c

Wnt-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100765
Super-classes obo:IMR_0000003c

Wnt-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100766
Super-classes obo:IMR_0000003c

Wnt-2bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100767
Super-classes obo:IMR_0000003c

Wnt-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100768
Super-classes obo:IMR_0000003c

Wnt-3ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100769
Super-classes obo:IMR_0000003c

Wnt-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100770
Super-classes obo:IMR_0000003c

Wnt-5ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100771
Super-classes obo:IMR_0000003c

Wnt-5bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100772
Super-classes obo:IMR_0000003c

Wnt-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100773
Super-classes obo:IMR_0000003c

Wnt-7ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100774
Super-classes obo:IMR_0000003c

Wnt-7bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100775
Super-classes obo:IMR_0000003c

Wnt-8ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100776
Super-classes obo:IMR_0000003c

Wnt-8bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100777
Super-classes obo:IMR_0000003c

Wnt-9ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100778
Super-classes obo:IMR_0000003c

Wnt-9bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100779
Super-classes obo:IMR_0000003c

Wnt-10ac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100780
Super-classes obo:IMR_0000003c

Wnt-10bc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100781
Super-classes obo:IMR_0000003c

Wnt-11c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100782
Super-classes obo:IMR_0000003c

Wnt-16c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100783
Super-classes obo:IMR_0000003c

LRP familyc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100798
Super-classes obo:IMR_0000974c
Sub-classes obo:IMR_0000973c
obo:IMR_0000975c
obo:IMR_0100799c
obo:IMR_0000964c
obo:IMR_0000963c
obo:IMR_0100800c
obo:IMR_0000977c
obo:IMR_0000962c
obo:IMR_0000978c
obo:IMR_0000976c
obo:IMR_0000970c

LRP1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100799
Super-classes obo:IMR_0100798c

LRP2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100800
Super-classes obo:IMR_0100798c

Casein kinase Ic # Classes

URI http://purl.obolibrary.org/obo/IMR_0100809
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:IMR_0100812c
obo:IMR_0100814c
obo:IMR_0100811c
obo:IMR_0100815c
obo:IMR_0100810c
obo:IMR_0100813c

CKI-alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100810
Super-classes obo:IMR_0100809c

CKI-gamma 1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100811
Super-classes obo:IMR_0100809c

CKI-gamma 2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100812
Super-classes obo:IMR_0100809c

CKI-gamma 3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100813
Super-classes obo:IMR_0100809c

CKI-deltac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100814
Super-classes obo:IMR_0100809c

CKI-epsilonc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100815
Super-classes obo:IMR_0100809c

SOCS-1c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100837
Super-classes obo:IMR_0000460c

SOCS-2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100838
Super-classes obo:IMR_0000460c

SOCS-3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100839
Super-classes obo:IMR_0000460c

SOCS-4c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100840
Super-classes obo:IMR_0000460c

SOCS-5c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100841
Super-classes obo:IMR_0000460c

SOCS-6c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100842
Super-classes obo:IMR_0000460c

SOCS-7c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100843
Super-classes obo:IMR_0000460c

Akt1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100844
Super-classes obo:IMR_0000250c
Sub-classes obo:TXPO_0002105c
obo:TXPO_0001799c

Akt2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100845
Super-classes obo:IMR_0000250c

Akt3c # Classes

URI http://purl.obolibrary.org/obo/IMR_0100846
Super-classes obo:IMR_0000250c

PKA type I alpha regulatory subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100847
Super-classes obo:IMR_0100702c

PKA type I beta regulatory subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100848
Super-classes obo:IMR_0100702c

PKA type II alpha regulatory subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100849
Super-classes obo:IMR_0100702c

PKA type II beta regulatory subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100850
Super-classes obo:IMR_0100702c

PKA alpha catalytic subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100851
Super-classes obo:IMR_0100703c

PKA beta catalytic subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100852
Super-classes obo:IMR_0100703c

PKA gamma catalytic subunitc # Classes

URI http://purl.obolibrary.org/obo/IMR_0100853
Super-classes obo:IMR_0100703c

IL-1 alphac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100854
Super-classes obo:IMR_0000011c

IL-1 betac # Classes

URI http://purl.obolibrary.org/obo/IMR_0100855
Super-classes obo:IMR_0000011c

Prostaglandin F2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0200051
Super-classes obo:IMR_0100019c

L-Asparaginec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200113
Super-classes obo:CHEBI_33709c

L-Histidinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200137
Super-classes obo:CHEBI_33709c

L-Lysinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200140
Super-classes obo:CHEBI_33709c

Prostaglandin E2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0200146
Super-classes obo:IMR_0100019c

L-Threoninec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200154
Super-classes obo:CHEBI_33709c

L-Prolinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200183
Super-classes obo:CHEBI_33709c

L-Tyrosinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200240
Super-classes obo:CHEBI_33709c

L-Alaninec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200251
Super-classes obo:CHEBI_33709c

Prostaglandin H2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0200253
Super-classes obo:IMR_0100019c

L-Isoleucinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200272
Super-classes obo:CHEBI_33709c

L-Phenylalaninec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200274
Super-classes obo:CHEBI_33709c

Prostaglandin I2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0200281
Super-classes obo:IMR_0100019c

L-Dopac # Classes

URI http://purl.obolibrary.org/obo/IMR_0200290
Super-classes obo:CHEBI_33709c

GMPc # Classes

URI http://purl.obolibrary.org/obo/IMR_0200292
Super-classes obo:CHEBI_36976c

L-Tryptophanc # Classes

URI http://purl.obolibrary.org/obo/IMR_0200307
Super-classes obo:CHEBI_33709c

L-Ornithinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200342
Super-classes obo:CHEBI_33709c

L-Argininec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200428
Super-classes obo:CHEBI_33709c

L-Glutaminec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200448
Super-classes obo:CHEBI_33709c

L-Serinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200453
Super-classes obo:CHEBI_33709c

Prostaglandin D2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0200457
Super-classes obo:IMR_0100019c

L-Aspartic acidc # Classes

URI http://purl.obolibrary.org/obo/IMR_0200459
Super-classes obo:CHEBI_33709c

L-Cysteinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200467
Super-classes obo:CHEBI_33709c

L-Methioninec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200488
Super-classes obo:CHEBI_33709c

L-Leucinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200492
Super-classes obo:CHEBI_33709c

Prostaglandin G2c # Classes

URI http://purl.obolibrary.org/obo/IMR_0200497
Super-classes obo:IMR_0100019c

L-Valinec # Classes

URI http://purl.obolibrary.org/obo/IMR_0200501
Super-classes obo:CHEBI_33709c

hypoxiac # Classes

URI http://purl.obolibrary.org/obo/MP_0005039
Super-classes obo:TXPO_0000671c
Sub-classes obo:TXPO_0002390c
obo:TXPO_0000978c
obo:TXPO_0000691c
obo:TXPO_0005017c

mus musculusc # Classes

URI http://purl.obolibrary.org/obo/NCBITaxon_10090
Super-classes obo:NCBITaxon_9989c

rattusc # Classes

URI http://purl.obolibrary.org/obo/NCBITaxon_10114
Super-classes obo:NCBITaxon_9989c

Eukaryotac # Classes

URI http://purl.obolibrary.org/obo/NCBITaxon_2759
Super-classes obo:OBI_0100026c
Sub-classes obo:NCBITaxon_7742c

mammaliac # Classes

URI http://purl.obolibrary.org/obo/NCBITaxon_40674
Super-classes obo:NCBITaxon_7742c
Sub-classes obo:NCBITaxon_9606c
obo:NCBITaxon_9989c

vertebratec # Classes

URI http://purl.obolibrary.org/obo/NCBITaxon_7742
Super-classes obo:NCBITaxon_2759c
Sub-classes obo:NCBITaxon_40674c

homo sapiensc # Classes

URI http://purl.obolibrary.org/obo/NCBITaxon_9606
Super-classes obo:NCBITaxon_40674c

rodentiac # Classes

URI http://purl.obolibrary.org/obo/NCBITaxon_9989
Super-classes obo:NCBITaxon_40674c
Sub-classes obo:NCBITaxon_10114c
obo:NCBITaxon_10090c

Buthionine sulfoximinec # Classes

URI http://purl.obolibrary.org/obo/NCIT_C1029
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0001942c

tumor-associated macrophagec # Classes

URI http://purl.obolibrary.org/obo/NCIT_C116387
Super-classes obo:CL_0000235c

cell survivalc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C16407
Super-classes obo:TXPO_0000414c
Restrictions obo:RO_0000057op some obo:CL_0000000c
Sub-classes obo:TXPO_0000377c
obo:TXPO_0000376c
obo:TXPO_0000280c
obo:TXPO_0000813c
obo:TXPO_0002363c

DNA damagec # Classes

URI http://purl.obolibrary.org/obo/NCIT_C16507
Super-classes obo:TXPO_0000222c
Sub-classes obo:TXPO_0004505c
obo:TXPO_0001198c
obo:TXPO_0000952c
obo:TXPO_0004121c
obo:TXPO_0000773c
obo:TXPO_0000223c

hydrolysisc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C16702
Super-classes obo:TXPO_0000185c
Sub-classes obo:TXPO_0003411c

carcinogenesisc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C18078
Super-classes obo:TXPO_0002703c
Sub-classes obo:TXPO_0002281c
obo:TXPO_0002534c
obo:NCIT_C19427c
obo:TXPO_0002319c

tumorigenesisc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C18121
Super-classes obo:TXPO_0000134c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
Sub-classes obo:TXPO_0000136c
obo:TXPO_0003209c
obo:TXPO_0001013c
obo:TXPO_0004218c
obo:TXPO_0000236c
obo:TXPO_0004392c
obo:TXPO_0000758c

metastasisc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C19151
Super-classes obo:GO_0016477c
Sub-classes obo:TXPO_0001497c
obo:TXPO_0001033c
obo:TXPO_0004479c

hepatocarcinogenesisc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C19427
Super-classes obo:NCIT_C18078c

clonal expansionc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C20613
Super-classes obo:GO_0008283c
Sub-classes obo:TXPO_0003867c

polypc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C3340
Super-classes obo:TXPO_0004047c

high levelc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C49508
Super-classes obo:TXPO_0004208c

occlusionc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C50678
Description

The act of closure or the state of being closed; an obstruction; the relationship between all of the components of the masticatory system in normal function, dysfunction, and parafunction; momentary complete closure of some area in the vocal tract, causing stoppage of the breath and accumulation of pressure.
Super-classes obo:TXPO_0002656c
Sub-classes obo:TXPO_0002713c

pathwayc # Classes

URI http://purl.obolibrary.org/obo/NCIT_C54214
Super-classes obo:TXPO_0000608c
Sub-classes obo:TXPO_0000609c
obo:TXPO_0000027c
obo:TXPO_0003222c
obo:TXPO_0000610c
obo:TXPO_0001902c
In range of obo:TXPO_0002524op

regulatory rolec # Classes

URI http://purl.obolibrary.org/obo/OBI_0000017
Super-classes obo:BFO_0000023c

assayc # Classes

URI http://purl.obolibrary.org/obo/OBI_0000070
Super-classes obo:BFO_0000015c
Sub-classes ncicp:C15958c
obo:TXPO_0000489c
obo:OBI_0000185c

patient rolec # Classes

URI http://purl.obolibrary.org/obo/OBI_0000093
Super-classes obo:CHEBI_52209c

imaging assayc # Classes

URI http://purl.obolibrary.org/obo/OBI_0000185
Super-classes obo:OBI_0000070c
Sub-classes obo:TXPO_0001396c

pathogen rolec # Classes

URI http://purl.obolibrary.org/obo/OBI_0000718
Super-classes obo:CHEBI_52209c

electron microscopy imaging assayc # Classes

URI http://purl.obolibrary.org/obo/OBI_0001631
Super-classes obo:TXPO_0001396c

secondary cultured cellc # Classes

URI http://purl.obolibrary.org/obo/OBI_0001866
Description

A secondary cultured cell has been passaged in culture or is a descendant of such a cell that is derived through propagation in culture.
Super-classes obo:CL_0000010c
Sub-classes obo:CLO_0000001c

organismc # Classes

URI http://purl.obolibrary.org/obo/OBI_0100026
Description

Its function is to do life activity.
Super-classes obo:BFO_0000040c
Restrictions obo:RO_0000086op some owl:Thingc
Sub-classes obo:NCBITaxon_2759c
In range of obo:TXPO_0003360op

predicted data itemc # Classes

URI http://purl.obolibrary.org/obo/OBI_0302867
Super-classes obo:TXPO_0000614c

occurrence of infectious diseasec # Classes

URI http://purl.obolibrary.org/obo/OBI_1110008
Super-classes obo:OGMS_0000063c

occurrence of allergyc # Classes

URI http://purl.obolibrary.org/obo/OBI_1110012
Super-classes obo:OGMS_0000063c

genec # Classes

URI http://purl.obolibrary.org/obo/OGG_0000000002
Description

Physical and functional unit of heredity, which carries information from one generation to the next. In molecular terms, it is the entire DNA sequence including exons, introns, and noncoding transcription-control regions necessary for production of a functional protein or RNA.
Super-classes obo:BFO_0000040c
Sub-classes obo:OGG_2000002759c

gene of Eukaryotac # Classes

URI http://purl.obolibrary.org/obo/OGG_2000002759
Super-classes obo:OGG_0000000002c
Restrictions obo:OGG_0000000016op some obo:NCBITaxon_2759c
Sub-classes obo:OGG_2000009606c

gene of Homo sapiensc # Classes

URI http://purl.obolibrary.org/obo/OGG_2000009606
Super-classes obo:OGG_2000002759c
Restrictions obo:OGG_0000000016op some obo:NCBITaxon_9606c
Sub-classes obo:OGG_2110009606c
obo:OGG_2070009606c
obo:OGG_2060009606c

protein-coding gene of Homo sapiensc # Classes

URI http://purl.obolibrary.org/obo/OGG_2060009606
Super-classes obo:OGG_2000009606c
Sub-classes obo:OGG_3000004001c
obo:OGG_3000001996c
obo:OGG_3000010125c
obo:OGG_3000000581c
obo:OGG_3000007298c
obo:OGG_3000010635c
obo:OGG_3000055224c
obo:OGG_3000002195c
obo:OGG_3000029128c
obo:OGG_3000051378c
obo:OGG_3000011124c
obo:OGG_3000064838c
obo:OGG_3000000348c
obo:OGG_3000007965c
obo:OGG_3000113612c
obo:OGG_3000004790c
obo:OGG_3000079789c
obo:OGG_3000057546c
obo:OGG_3000006045c
obo:OGG_3000001551c
obo:OGG_3000000578c
obo:OGG_3000007804c
obo:OGG_3000005465c
obo:OGG_3000007832c
obo:OGG_3000051594c
obo:OGG_3000009709c
obo:OGG_3000001601c
obo:OGG_3000022861c
obo:OGG_3000009439c
obo:OGG_3000080255c
obo:OGG_3000120526c
obo:OGG_3000007076c
obo:OGG_3000001508c
obo:OGG_3000029896c
obo:OGG_3000007184c
obo:OGG_3000122618c
obo:OGG_3000029103c
obo:OGG_3000006554c
obo:OGG_3000049855c
obo:OGG_3000004763c
obo:OGG_3000002908c
obo:OGG_3000004830c
obo:OGG_3000084320c
obo:OGG_3000000285c
obo:OGG_3000064081c
obo:OGG_3000022926c
obo:OGG_3000006794c
obo:OGG_3000284161c
obo:OGG_3000079982c
obo:OGG_3000029948c
obo:OGG_3000057216c
obo:OGG_3000010218c
obo:OGG_3000010741c
obo:OGG_3000005101c
obo:OGG_3000011145c
obo:OGG_3000002877c
obo:OGG_3000001984c
obo:OGG_3000054431c
obo:OGG_3000003592c
obo:OGG_3000023234c
obo:OGG_3000001545c
obo:OGG_3000066002c
obo:OGG_3000000356c
obo:OGG_3000009970c
obo:OGG_3000641371c
obo:OGG_3000008672c
obo:OGG_3000001062c
obo:OGG_3000001544c
obo:OGG_3000008856c
obo:OGG_3000001981c
obo:OGG_3000023594c
obo:OGG_3000002833c
obo:OGG_3000027000c
obo:OGG_3000001557c
obo:OGG_3000001719c
obo:OGG_3000001649c
obo:OGG_3000007357c
obo:OGG_3000000839c
obo:OGG_3000003338c
obo:OGG_3000002168c
obo:OGG_3000000123c
obo:OGG_3000001582c
obo:OGG_3000008894c
obo:OGG_3000001581c
obo:OGG_3000003604c
obo:OGG_3000009939c
obo:OGG_3000000637c
obo:OGG_3000051129c
obo:OGG_3000000317c
obo:OGG_3000153020c
obo:OGG_3000001647c
obo:OGG_3000001964c
obo:OGG_3000023581c
obo:OGG_3000000229c
obo:OGG_3000081575c
obo:OGG_3000079071c
obo:OGG_3000004673c
obo:OGG_3000001572c
obo:OGG_3000004189c
obo:OGG_3000005599c
obo:OGG_3000168620c
obo:OGG_3000000545c
obo:OGG_3000001571c
obo:OGG_3000051726c
obo:OGG_3000005872c
obo:OGG_3000011343c
obo:OGG_3000064215c
obo:OGG_3000006608c
obo:OGG_3000006235c
obo:OGG_3000001591c
obo:OGG_3000008517c
obo:OGG_3000079094c
obo:OGG_3000005350c
obo:OGG_3000284541c
obo:OGG_3000415116c
obo:OGG_3000007186c
obo:OGG_3000001728c
obo:OGG_3000001958c
obo:OGG_3000003488c
obo:OGG_3000009768c
obo:OGG_3000084085c
obo:OGG_3000002817c
obo:OGG_3000001973c
obo:OGG_3000054541c
obo:OGG_3000143244c
obo:OGG_3000010923c
obo:OGG_3000056605c
obo:OGG_3000001386c
obo:OGG_3000083939c
obo:OGG_3000004925c
obo:OGG_3000000788c
obo:OGG_3000010049c
obo:OGG_3000003484c
obo:OGG_3000199974c
obo:OGG_3000022826c
obo:OGG_3000003553c
obo:OGG_3000008935c
obo:OGG_3000022977c
obo:OGG_3000201163c
obo:OGG_3000005308c
obo:OGG_3000005463c
obo:OGG_3000348235c
obo:OGG_3000023341c
obo:OGG_3000002619c
obo:OGG_3000283927c
obo:OGG_3000006347c
obo:OGG_3000007352c
obo:OGG_3000011283c
obo:OGG_3000000572c
obo:OGG_3000008575c
obo:OGG_3000126410c
obo:OGG_3000026286c
obo:OGG_3000079174c
obo:OGG_3000003486c
obo:OGG_3000094241c
obo:OGG_3000203228c
obo:OGG_3000054658c
obo:OGG_3000001978c
obo:OGG_3000002673c
obo:OGG_3000006772c
obo:OGG_3000163590c
obo:OGG_3000112849c
obo:OGG_3000002940c
obo:OGG_3000023753c
obo:OGG_3000011332c
obo:OGG_3000005034c
obo:OGG_3000000443c
obo:OGG_3000004018c
obo:OGG_3000000125c
obo:OGG_3000003560c
obo:OGG_3000002538c
obo:OGG_3000001543c
obo:OGG_3000001374c
obo:OGG_3000005288c
obo:OGG_3000026512c
obo:OGG_3000000207c
obo:OGG_3000004023c
obo:OGG_3000007124c
obo:OGG_3000004047c
obo:OGG_3000051330c
obo:OGG_3000005562c
obo:OGG_3000054905c
obo:OGG_3000003309c
obo:OGG_3000009965c
obo:OGG_3000131118c
obo:OGG_3000005579c
obo:OGG_3000008870c
obo:OGG_3000085406c
obo:OGG_3000009994c
obo:OGG_3000000782c
obo:OGG_3000000325c
obo:OGG_3000001340c
obo:OGG_3000001284c
obo:OGG_3000347252c
obo:OGG_3000122970c
obo:OGG_3000000211c
obo:OGG_3000113130c
obo:OGG_3000000012c
obo:OGG_3000065992c
obo:OGG_3000285440c
obo:OGG_3000007296c
obo:OGG_3000009451c
obo:OGG_3000002259c
obo:OGG_3000005775c
obo:OGG_3000317649c
obo:OGG_3000055304c
obo:OGG_3000003558c
obo:OGG_3000006609c
obo:OGG_3000006372c
obo:OGG_3000008663c
obo:OGG_3000001584c
obo:OGG_3000008668c
obo:OGG_3000003177c
obo:OGG_3000009144c
obo:OGG_3000005322c
obo:OGG_3000003778c
obo:OGG_3000001968c
obo:OGG_3000387103c
obo:OGG_3000003491c
obo:OGG_3000001583c
obo:OGG_3000002937c
obo:OGG_3000006093c
obo:OGG_3000003021c
obo:OGG_3000005447c
obo:OGG_3000001549c
obo:OGG_3000260293c
obo:OGG_3000001842c
obo:OGG_3000027286c
obo:OGG_3000000355c
obo:OGG_3000129607c
obo:OGG_3000006046c
obo:OGG_3000003833c
obo:OGG_3000010419c
obo:OGG_3000055190c
obo:OGG_3000001975c
obo:OGG_3000002863c
obo:OGG_3000003565c
obo:OGG_3000003159c
obo:OGG_3000000835c
obo:OGG_3000003638c
obo:OGG_3000000597c
obo:OGG_3000010209c
obo:OGG_3000003569c
obo:OGG_3000000466c
obo:OGG_3000002308c
obo:OGG_3000003032c
obo:OGG_3000083729c
obo:OGG_3000001589c
obo:OGG_3000010289c
obo:OGG_3000002272c
obo:OGG_3000150353c
obo:OGG_3000002947c
obo:OGG_3000001586c
obo:OGG_3000009926c
obo:OGG_3000000900c
obo:OGG_3000000834c
obo:OGG_3000010858c
obo:OGG_3000027244c
obo:OGG_3000056603c
obo:OGG_3000009829c
obo:OGG_3000006774c
obo:OGG_3000008431c
obo:OGG_3000055289c
obo:OGG_3000003690c
obo:OGG_3000009175c
obo:OGG_3000083452c
obo:OGG_3000151126c
obo:OGG_3000000031c
obo:OGG_3000053354c
obo:OGG_3000004791c
obo:OGG_3000010803c
obo:OGG_3000008876c
obo:OGG_3000025987c
obo:OGG_3000000840c
obo:OGG_3000001950c
obo:OGG_3000009518c
obo:OGG_3000011080c
obo:OGG_3000009068c
obo:OGG_3000001191c
obo:OGG_3000007410c
obo:OGG_3000055632c
obo:OGG_3000090693c
obo:OGG_3000025833c
obo:OGG_3000000427c
obo:OGG_3000007458c
obo:OGG_3000004258c
obo:OGG_3000000595c
obo:OGG_3000010586c
obo:OGG_3000005372c
obo:OGG_3000055192c
obo:OGG_3000002237c
obo:OGG_3000002729c
obo:OGG_3000009972c
obo:OGG_3000084649c
obo:OGG_3000080063c
obo:OGG_3000002730c
obo:OGG_3000552891c
obo:OGG_3000057834c
obo:OGG_3000002826c
obo:OGG_3000003182c
obo:OGG_3000055331c
obo:OGG_3000006515c
obo:OGG_3000022996c
obo:OGG_3000008664c
obo:OGG_3000000997c
obo:OGG_3000004193c
obo:OGG_3000348158c
obo:OGG_3000001388c
obo:OGG_3000001974c
obo:OGG_3000000032c
obo:OGG_3000008743c
obo:OGG_3000080331c
obo:OGG_3000548645c
obo:OGG_3000085479c
obo:OGG_3000051477c
obo:OGG_3000002551c
obo:OGG_3000010480c
obo:OGG_3000001962c
obo:OGG_3000083695c
obo:OGG_3000009159c
obo:OGG_3000009804c
obo:OGG_3000004747c
obo:OGG_3000001558c
obo:OGG_3000000596c
obo:OGG_3000010020c
obo:OGG_3000006400c
obo:OGG_3000027242c
obo:OGG_3000064344c
obo:OGG_3000001233c
obo:OGG_3000004313c
obo:OGG_3000010401c
obo:OGG_3000027335c
obo:OGG_3000002494c
obo:OGG_3000026973c
obo:OGG_3000257019c
obo:OGG_3000023645c
obo:OGG_3000010952c
obo:OGG_3000006880c
obo:OGG_3000116842c
obo:OGG_3000002114c
obo:OGG_3000010539c
obo:OGG_3000003084c
obo:OGG_3000003055c
obo:OGG_3000010273c
obo:OGG_3000202052c
obo:OGG_3000123688c
obo:OGG_3000002247c
obo:OGG_3000005290c
obo:OGG_3000054951c
obo:OGG_3000054788c
obo:OGG_3000010580c
obo:OGG_3000001939c
obo:OGG_3000004605c
obo:OGG_3000000838c
obo:OGG_3000010926c
obo:OGG_3000001052c
obo:OGG_3000001235c
obo:OGG_3000056478c
obo:OGG_3000003158c
obo:OGG_3000055856c
obo:OGG_3000387755c
obo:OGG_3000004616c
obo:OGG_3000001174c
obo:OGG_3000008544c
obo:OGG_3000001237c
obo:OGG_3000010005c
obo:OGG_3000009648c
obo:OGG_3000001236c
obo:OGG_3000008893c
obo:OGG_3000055089c
obo:OGG_3000010053c
obo:OGG_3000006733c
obo:OGG_3000340485c
obo:OGG_3000010553c
obo:OGG_3000001956c
obo:OGG_3000051250c
obo:OGG_3000054943c
obo:OGG_3000000760c
obo:OGG_3000008890c
obo:OGG_3000009669c
obo:OGG_3100133790c
obo:OGG_3000641372c
obo:OGG_3000009470c
obo:OGG_3000008666c
obo:OGG_3000001656c
obo:OGG_3000027241c
obo:OGG_3000009775c
obo:OGG_3000023210c
obo:OGG_3000027329c
obo:OGG_3000051277c
obo:OGG_3000009971c
obo:OGG_3000064782c
obo:OGG_3000003726c
obo:OGG_3000084285c
obo:OGG_3000001806c
obo:OGG_3000340665c
obo:OGG_3000005608c
obo:OGG_3000011164c
obo:OGG_3000000846c
obo:OGG_3000009086c
obo:OGG_3000001234c
obo:OGG_3000005106c
obo:OGG_3000010382c
obo:OGG_3000001230c
obo:OGG_3000003551c
obo:OGG_3000009415c
obo:OGG_3000002081c
obo:OGG_3000089978c
obo:OGG_3000005319c
obo:OGG_3000007157c
obo:OGG_3000056521c
obo:OGG_3000374407c
obo:OGG_3000008647c
obo:OGG_3000064241c
obo:OGG_3000055629c
obo:OGG_3000004345c
obo:OGG_3000005933c
obo:OGG_3000003586c
obo:OGG_3000079962c
obo:OGG_3000001983c
obo:OGG_3000029923c
obo:OGG_3000004259c
obo:OGG_3000001906c
obo:OGG_3000003157c
obo:OGG_3000006319c
obo:OGG_3000051390c
obo:OGG_3000116150c
obo:OGG_3000001576c
obo:OGG_3000414061c
obo:OGG_3000057600c
obo:OGG_3000055819c
obo:OGG_3000001967c
obo:OGG_3000005366c
obo:OGG_3000001026c
obo:OGG_3000004780c
obo:OGG_3000084277c
obo:OGG_3000051512c
obo:OGG_3000005570c
obo:OGG_3000007266c
obo:OGG_3000005890c
obo:OGG_3000029118c
obo:OGG_3000000196c
obo:OGG_3000728689c
obo:OGG_3000353322c
obo:OGG_3000080235c
obo:OGG_3000056910c
obo:OGG_3000005095c
obo:OGG_3000010965c
obo:OGG_3000003300c
obo:OGG_3000005105c
obo:OGG_3000000635c
obo:OGG_3000005610c
obo:OGG_3000001979c
obo:OGG_3000023475c
obo:OGG_3000029785c
obo:OGG_3000008669c
obo:OGG_3000064816c
obo:OGG_3000007187c
obo:OGG_3000001579c
obo:OGG_3000000208c
obo:OGG_3000001316c
obo:OGG_3000003490c
obo:OGG_3000008800c
obo:OGG_3000029028c
obo:OGG_3000051302c
obo:OGG_3000161253c
obo:OGG_3000253314c
obo:OGG_3000090668c
obo:OGG_3000005824c
obo:OGG_3000001965c
obo:OGG_3000011163c
obo:OGG_3000005991c
obo:OGG_3000003727c
obo:OGG_3000023597c
obo:OGG_3000055109c
obo:OGG_3000055741c
obo:OGG_3000001585c
obo:OGG_3000003337c
obo:OGG_3000007112c
obo:OGG_3000001577c
obo:OGG_3000060312c
obo:OGG_3000003688c
obo:OGG_3000253935c
obo:OGG_3000001588c
obo:OGG_3000001553c
obo:OGG_3000166785c
obo:OGG_3000165721c
obo:OGG_3000006341c
obo:OGG_3000079882c
obo:OGG_3000002539c
obo:OGG_3000002549c
obo:OGG_3000064332c
obo:OGG_3000084263c
obo:OGG_3000008337c
obo:OGG_3000001593c
obo:OGG_3000007099c
obo:OGG_3000001562c
obo:OGG_3000010525c
obo:OGG_3000007057c
obo:OGG_3000008891c
obo:OGG_3000000602c
obo:OGG_3000010417c
obo:OGG_3000000960c
obo:OGG_3000009871c
obo:OGG_3000011016c
obo:OGG_3000008661c
obo:OGG_3000005166c
obo:OGG_3000004613c
obo:OGG_3000000837c
obo:OGG_3000026291c
obo:OGG_3000000843c
obo:OGG_3000002206c
obo:OGG_3000009400c
obo:OGG_3000123876c
obo:OGG_3000135932c
obo:OGG_3000093273c
obo:OGG_3000246175c
obo:OGG_3000008717c
obo:OGG_3000064327c
obo:OGG_3000009517c
obo:OGG_3000011010c
obo:OGG_3000023452c
obo:OGG_3000080267c
obo:OGG_3000007364c
obo:OGG_3000025822c
obo:OGG_3000003725c
obo:OGG_3000010243c
obo:OGG_3000006782c
obo:OGG_3000001977c
obo:OGG_3000003339c
obo:OGG_3000005021c
obo:OGG_3000115265c
obo:OGG_3000007873c
obo:OGG_3000007494c
obo:OGG_3000000283c
obo:OGG_3000007291c
obo:OGG_3000000842c
obo:OGG_3000008529c
obo:OGG_3000001594c
obo:OGG_3000055735c
obo:OGG_3000120227c
obo:OGG_3000000983c
obo:OGG_3000197350c
obo:OGG_3000006747c
obo:OGG_3000006519c
obo:OGG_3000196463c
obo:OGG_3000026027c
obo:OGG_3000027102c
obo:OGG_3000003162c
obo:OGG_3000441027c
obo:OGG_3000003552c
obo:OGG_3000285126c
obo:OGG_3000006720c
obo:OGG_3000005138c
obo:OGG_3000055571c
obo:OGG_3000128553c
obo:OGG_3000079799c
obo:OGG_3000003489c
obo:OGG_3000002674c
obo:OGG_3000004609c
obo:OGG_3100861540c
obo:OGG_3000000841c
obo:OGG_3000008339c
obo:OGG_3000000836c
obo:OGG_3000002166c
obo:OGG_3000003956c
obo:OGG_3000010924c
obo:OGG_3000000284c
obo:OGG_3000002339c
obo:OGG_3000010404c
obo:OGG_3000008817c
obo:OGG_3000151056c
obo:OGG_3000004257c
obo:OGG_3000056648c
obo:OGG_3000009891c
obo:OGG_3000008665c
obo:OGG_3000051141c
obo:OGG_3000134526c
obo:OGG_3000009420c
obo:OGG_3000002335c
obo:OGG_3000009133c
obo:OGG_3000008667c
obo:OGG_3000729230c
obo:OGG_3000339761c
obo:OGG_3000010018c
obo:OGG_3000008637c
obo:OGG_3000008837c
obo:OGG_3000004051c
obo:OGG_3000007392c
obo:OGG_3000055729c
obo:OGG_3000005777c
obo:OGG_3000011014c
obo:OGG_3000000467c
obo:OGG_3000006426c
obo:OGG_3000050810c
obo:OGG_3000009695c
obo:OGG_3000022809c
obo:OGG_3000003659c
obo:OGG_3000114827c
obo:OGG_3000006742c
obo:OGG_3000084696c
obo:OGG_3000010769c
obo:OGG_3000008892c
obo:OGG_3000000216c
obo:OGG_3000084675c
obo:OGG_3000009641c
obo:OGG_3000000639c
obo:OGG_3000000468c
obo:OGG_3000001376c
obo:OGG_3000374383c
obo:OGG_3000063934c
obo:OGG_3000051147c
obo:OGG_3000134218c
obo:OGG_3000133746c
obo:OGG_3000090637c
obo:OGG_3000057153c
obo:OGG_3000001565c
obo:OGG_3000001559c
obo:OGG_3000026061c
obo:OGG_3000003487c
obo:OGG_3000001595c
obo:OGG_3000001573c
obo:OGG_3000003161c
obo:OGG_3000001831c
obo:OGG_3000003646c
obo:OGG_3000003485c
obo:OGG_3000006606c
obo:OGG_3000000101c
obo:OGG_3000007376c
obo:OGG_3000005611c
obo:OGG_3000001982c
obo:OGG_3000140809c
obo:OGG_3000023317c
obo:OGG_3100506742c
obo:OGG_3000000771c
obo:OGG_3000023659c
obo:OGG_3000001555c
obo:OGG_3000001891c
obo:OGG_3000008662c
obo:OGG_3000006506c
obo:OGG_3000051386c
obo:OGG_3000006876c
obo:OGG_3000008309c
obo:OGG_3000112476c
obo:OGG_3000002918c
obo:OGG_3000001232c
obo:OGG_3000128346c
obo:OGG_3000009188c
obo:OGG_3000057404c
obo:OGG_3000000291c
obo:OGG_3000005734c
obo:OGG_3000440275c
obo:OGG_3000003692c
obo:OGG_3000008851c
obo:OGG_3000006819c
obo:OGG_3000010542c
obo:OGG_3000010611c
obo:OGG_3000001401c
obo:OGG_3000010857c
obo:OGG_3000083854c
obo:OGG_3000091543c
obo:OGG_3000004318c
obo:OGG_3000029089c
obo:OGG_3000007329c
obo:OGG_3000010670c
obo:OGG_3000001592c
obo:OGG_3000064787c
obo:OGG_3000001580c
obo:OGG_3000022843c
obo:OGG_3000008884c
obo:OGG_3000008310c
obo:OGG_3000004199c
obo:OGG_3000029078c
obo:OGG_3000005241c
obo:OGG_3000001548c
obo:OGG_3000000051c
obo:OGG_3000009221c
obo:OGG_3000002171c
obo:OGG_3000008879c
obo:OGG_3000057761c

pseudo gene of Homo sapiensc # Classes

URI http://purl.obolibrary.org/obo/OGG_2070009606
Super-classes obo:OGG_2000009606c
Sub-classes obo:OGG_3000055350c
obo:OGG_3000319118c
obo:OGG_3000003116c
obo:OGG_3000023766c

ncRNA gene of Homo sapiensc # Classes

URI http://purl.obolibrary.org/obo/OGG_2100009606
Super-classes obo:OGG_2110009606c
Sub-classes obo:OGG_3000150759c
obo:OGG_3000406925c
obo:TXPO_0004623c
obo:OGG_3000406942c
obo:OGG_3000283131c
obo:OGG_3000005820c
obo:TXPO_0004733c
obo:OGG_3000390756c
obo:OGG_3000406926c

RNA gene of Homo sapiensc # Classes

URI http://purl.obolibrary.org/obo/OGG_2110009606
Super-classes obo:OGG_2000009606c
Sub-classes obo:OGG_2100009606c

SERPINA3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000012
Description

Other designations: alpha-1-antichymotrypsin|cell growth-inhibiting gene 24/25 protein|growth-inhibiting protein 24|growth-inhibiting protein 25|serine (or cysteine) proteinase inhibitor, clade A, member 3|serpin A3
Super-classes obo:OGG_2060009606c

ACACAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000031
Description

Other designations: ACC-alpha|acetyl-CoA carboxylase 1|acetyl-Coenzyme A carboxylase alpha
Super-classes obo:OGG_2060009606c

ACACBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000032
Description

Other designations: ACC-beta|acetyl-CoA carboxylase 2|acetyl-Coenzyme A carboxylase beta
Super-classes obo:OGG_2060009606c

ACOX1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000051
Description

Other designations: AOX|acyl-CoA oxidase, straight-chain|acyl-Coenzyme A oxidase 1, palmitoyl|palmitoyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 1|peroxisomal fatty acyl-CoA oxidase|straight-chain acyl-CoA oxidase
Super-classes obo:OGG_2060009606c

ADAM8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000101
Description

Other designations: a disintegrin and metalloproteinase domain 8|cell surface antigen MS2|disintegrin and metalloproteinase domain-containing protein 8|human leukocyte differentiation antigen
Super-classes obo:OGG_2060009606c

PLIN2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000123
Description

Other designations: adipophilin|adipose differentiation-related protein|perilipin-2
Super-classes obo:OGG_2060009606c

ADH1Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000125
Description

Other designations: ADH, beta subunit|alcohol dehydrogenase 1B|alcohol dehydrogenase 2 (class I), beta polypeptide|alcohol dehydrogenase subunit beta|aldehyde reductase|epididymis secretory protein Li 117
Super-classes obo:OGG_2060009606c

AHRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000196
Description

Other designations: AH-receptor|ah receptor|aromatic hydrocarbon receptor|class E basic helix-loop-helix protein 76
Super-classes obo:OGG_2060009606c

AKT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000207
Description

Other designations: PKB alpha|RAC-PK-alpha|RAC-alpha serine/threonine-protein kinase|protein kinase B alpha|proto-oncogene c-Akt|rac protein kinase alpha
Super-classes obo:OGG_2060009606c

AKT2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000208
Description

Other designations: PKB beta|RAC-PK-beta|RAC-beta serine/threonine-protein kinase|murine thymoma viral (v-akt) homolog-2|protein kinase Akt-2|protein kinase B beta|rac protein kinase beta
Super-classes obo:OGG_2060009606c

ALAS1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000211
Description

Other designations: 5-aminolevulinate synthase, nonspecific, mitochondrial|5-aminolevulinic acid synthase 1|ALAS-H|delta-ALA synthase 1|delta-aminolevulinate synthase 1|migration-inducing protein 4
Super-classes obo:OGG_2060009606c

ALDH1A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000216
Description

Other designations: ALDH class 1|ALHDII|RALDH 1|acetaldehyde dehydrogenase 1|aldehyde dehydrogenase 1, soluble|aldehyde dehydrogenase, liver cytosolic|epididymis luminal protein 12|epididymis luminal protein 9|epididymis secretory sperm binding protein Li 53e|retinal dehydrogenase 1|retinaldehyde dehydrogenase 1
Super-classes obo:OGG_2060009606c

ALDOBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000229
Description

Other designations: aldolase 2|aldolase B, fructose-bisphosphatase|fructose-bisphosphate aldolase B|liver-type aldolase
Super-classes obo:OGG_2060009606c

ANGc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000283
Description

Other designations: RNase 5|angiogenin|epididymis luminal protein 168|ribonuclease 5|ribonuclease A A1
Super-classes obo:OGG_2060009606c

ANGPT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000284
Description

Other designations: ANG-1|angiopoietin-1
Super-classes obo:OGG_2060009606c

ANGPT2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000285
Description

Other designations: ANG-2|Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
Super-classes obo:OGG_2060009606c

SLC25A4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000291
Description

Other designations: ADP,ATP carrier protein 1|ADP,ATP carrier protein, heart/skeletal muscle|ADP/ATP translocase 1|adenine nucleotide translocator 1 (skeletal muscle)|heart/skeletal muscle ATP/ADP translocator|solute carrier family 25 member 4
Super-classes obo:OGG_2060009606c

APAF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000317
Description

Other designations: apoptotic protease-activating factor 1
Super-classes obo:OGG_2060009606c

APCSc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000325
Description

Other designations: 9.5S alpha-1-glycoprotein|epididymis secretory sperm binding protein Li 92n|pentaxin-related|serum amyloid P-component
Super-classes obo:OGG_2060009606c

APOEc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000348
Description

Other designations: apo-E|apolipoprotein E3
Super-classes obo:OGG_2060009606c

FASc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000355
Description

Other designations: APO-1 cell surface antigen|CD95 antigen|Delta Fas/APO-1/CD95|FAS 827dupA|FAS receptor variant 9|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas AMA|TNF receptor superfamily member 6|apoptosis antigen 1|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6|tumor necrosis factor receptor superfamily, member 6
Super-classes obo:OGG_2060009606c

FASLGc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000356
Description

Other designations: CD95 ligand|apoptosis (APO-1) antigen ligand 1|apoptosis antigen ligand|fas antigen ligand|tumor necrosis factor (ligand) superfamily, member 6|tumor necrosis factor ligand superfamily member 6
Super-classes obo:OGG_2060009606c

ASAH1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000427
Description

Other designations: acid CDase|acid ceramidase|acylsphingosine deacylase|putative 32 kDa heart protein
Super-classes obo:OGG_2060009606c

ASPAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000443
Description

Other designations: ACY-2|aminoacylase 2|aminoacylase-2
Super-classes obo:OGG_2060009606c

ATF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000466
Description

Other designations: cAMP-dependent transcription factor ATF-1|cyclic AMP-dependent transcription factor ATF-1
Super-classes obo:OGG_2060009606c

ATF3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000467
Description

Other designations: cAMP-dependent transcription factor ATF-3|cyclic AMP-dependent transcription factor ATF-3
Super-classes obo:OGG_2060009606c

ATF4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000468
Description

Other designations: DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-responsive enhancer element B67|tax-responsive enhancer element-binding protein 67
Super-classes obo:OGG_2060009606c

ATRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000545
Description

Other designations: FRAP-related protein 1|FRAP-related protein-1|MEC1, mitosis entry checkpoint 1, homolog|Rad3 related protein|ataxia telangiectasia and Rad3-related protein|protein kinase ATR|serine/threonine-protein kinase ATR
Super-classes obo:OGG_2060009606c

BADc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000572
Description

Other designations: BCL-X/BCL-2 binding protein|BCL2-antagonist of cell death protein|BCL2-binding component 6|BCL2-binding protein|bcl-2-binding component 6|bcl-2-like protein 8|bcl-XL/Bcl-2-associated death promoter|bcl2 antagonist of cell death|bcl2-L-8
Super-classes obo:OGG_2060009606c

BAK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000578
Description

Other designations: BCL2-like 7 protein|apoptosis regulator BAK|bcl-2 homologous antagonist/killer|bcl-2-like protein 7|bcl2-L-7|pro-apoptotic protein BAK
Super-classes obo:OGG_2060009606c

BAXc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000581
Description

Other designations: BCL2-associated X protein omega|BCL2-associated X protein transcript variant delta2|apoptosis regulator BAX|bcl-2-like protein 4|bcl2-L-4
Super-classes obo:OGG_2060009606c

CCND1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000595
Description

Other designations: B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene
Super-classes obo:OGG_2060009606c

BCL2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000596
Description

Other designations: apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50
Super-classes obo:OGG_2060009606c

BCL2A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000597
Description

Other designations: bcl-2-like protein 5|bcl-2-related protein A1|bcl2-L-5|hematopoietic BCL2-related protein A1|hemopoietic-specific early response protein|protein BFL-1
Super-classes obo:OGG_2060009606c

BCL3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000602
Description

Other designations: B-cell leukemia/lymphoma 3|B-cell lymphoma 3 protein|B-cell lymphoma 3-encoded protein|BCL-3|chronic lymphatic leukemia protein|proto-oncogene BCL3
Super-classes obo:OGG_2060009606c

BHMTc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000635
Description

Other designations: betaine--homocysteine S-methyltransferase 1|epididymis secretory sperm binding protein Li 61p
Super-classes obo:OGG_2060009606c

BIDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000637
Description

Other designations: BH3-interacting domain death agonist|BID isoform ES(1b)|BID isoform L(2)|BID isoform Si6|Human BID coding sequence|apoptic death agonist|desmocollin type 4|p22 BID
Super-classes obo:OGG_2060009606c

PRDM1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000639
Description

Other designations: B-lymphocyte-induced maturation protein 1|BLIMP-1|PR domain zinc finger protein 1|PRDI-binding factor-1|beta-interferon gene positive-regulatory domain I binding factor
Super-classes obo:OGG_2060009606c

CA2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000760
Description

Other designations: carbonate dehydratase II|carbonic anhydrase 2|carbonic anhydrase B|carbonic anhydrase C|carbonic dehydratase|epididymis luminal protein 76
Super-classes obo:OGG_2060009606c

CA12c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000771
Description

Other designations: CA-XII|carbonate dehydratase XII|carbonic anhydrase 12|carbonic dehydratase|tumor antigen HOM-RCC-3.1.3
Super-classes obo:OGG_2060009606c

CACNB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000782
Description

Other designations: calcium channel voltage-dependent subunit beta 1|calcium channel, L type, beta 1 polypeptide|dihydropyridine-sensitive L-type, calcium channel beta-1 subunit|voltage-dependent L-type calcium channel subunit beta-1
Super-classes obo:OGG_2060009606c

SLC25A20c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000788
Description

Other designations: mitochondrial carnitine/acylcarnitine carrier protein
Super-classes obo:OGG_2060009606c

CASP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000834
Description

Other designations: CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
Super-classes obo:OGG_2060009606c

CASP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000835
Description

Other designations: caspase-2|neural precursor cell expressed developmentally down-regulated protein 2|protease ICH-1|protein phosphatase 1, regulatory subunit 57
Super-classes obo:OGG_2060009606c

CASP3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000836
Description

Other designations: CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama
Super-classes obo:OGG_2060009606c

CASP4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000837
Description

Other designations: CASP-4|ICE(rel)-II|apoptotic cysteine protease Mih1/TX|caspase 4, apoptosis-related cysteine protease|caspase-4|protease ICH-2|protease TX
Super-classes obo:OGG_2060009606c

CASP5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000838
Description

Other designations: CASP-5|ICE(rel)-III|TY protease|caspase 5, apoptosis-related cysteine protease|caspase-5|protease ICH-3|protease TY
Super-classes obo:OGG_2060009606c

CASP6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000839
Description

Other designations: apoptotic protease MCH-2|caspase 6, apoptosis-related cysteine protease|caspase-6
Super-classes obo:OGG_2060009606c

CASP7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000840
Description

Other designations: ICE-like apoptotic protease 3|apoptotic protease MCH-3|caspase 7, apoptosis-related cysteine protease|caspase-7
Super-classes obo:OGG_2060009606c

CASP8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000841
Description

Other designations: FADD-homologous ICE/CED-3-like protease|FADD-like ICE|ICE-like apoptotic protease 5|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|MORT1-associated ced-3 homolog|apoptotic cysteine protease|apoptotic protease Mch-5|caspase 8, apoptosis-related cysteine protease|caspase-8
Super-classes obo:OGG_2060009606c

CASP9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000842
Description

Other designations: ICE-like apoptotic protease 6|apoptotic protease MCH-6|apoptotic protease activating factor 3|caspase-9|protein phosphatase 1, regulatory subunit 56
Super-classes obo:OGG_2060009606c

CASP10c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000843
Description

Other designations: CASP-10|FADD-like ICE2|FAS-associated death domain protein interleukin-1B-converting enzyme 2|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10, apoptosis-related cysteine protease|caspase-10|interleukin-1B-converting enzyme 2
Super-classes obo:OGG_2060009606c

CASRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000846
Description

Other designations: extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1|parathyroid cell calcium-sensing receptor 1
Super-classes obo:OGG_2060009606c

CCNG1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000900
Description

Other designations: cyclin-G|cyclin-G1
Super-classes obo:OGG_2060009606c

CD44c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000960
Description

Other designations: CD44 antigen|GP90 lymphocyte homing/adhesion receptor|Hermes antigen|cell surface glycoprotein CD44|chondroitin sulfate proteoglycan 8|epican|extracellular matrix receptor III|hematopoietic cell E- and L-selectin ligand|heparan sulfate proteoglycan|homing function and Indian blood group system|hyaluronate receptor|phagocytic glycoprotein 1
Super-classes obo:OGG_2060009606c

CDK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000983
Description

Other designations: cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase
Super-classes obo:OGG_2060009606c

CDC34c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000000997
Description

Other designations: cell division cycle 34 homolog|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 R1|ubiquitin-conjugating enzyme E2-32 KDA complementing|ubiquitin-conjugating enzyme E2-CDC34|ubiquitin-protein ligase R1
Super-classes obo:OGG_2060009606c

CDKN1Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001026
Description

Other designations: CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1
Super-classes obo:OGG_2060009606c

CEBPDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001052
Description

Other designations: CCAAT/enhancer-binding protein delta|c/EBP delta|nuclear factor NF-IL6-beta
Super-classes obo:OGG_2060009606c

CENPEc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001062
Description

Other designations: Centromere autoantigen E (312kD)|centromere-associated protein E|kinesin family member 10|kinesin-related protein CENPE|protein phosphatase 1, regulatory subunit 61
Super-classes obo:OGG_2060009606c

AP1S1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001174
Description

Other designations: AP-1 complex subunit sigma-1A|HA1 19 kDa subunit|adapter-related protein complex 1 sigma-1A subunit|adapter-related protein complex 1 subunit sigma-1A|adaptor protein complex AP-1 subunit sigma-1A|clathrin assembly protein complex 1 sigma-1A small chain|clathrin coat assembly protein AP19|clathrin-associated/assembly/adaptor protein, small 1 (19kD)|erythrokeratodermia variabilis 3 (Kamouraska type)|golgi adaptor HA1/AP1 adaptin sigma-1A subunit|sigma1A subunit of AP-1 clathrin adaptor complex|sigma1A-adaptin
Super-classes obo:OGG_2060009606c

CLUc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001191
Description

Other designations: aging-associated protein 4|apolipoprotein J|complement cytolysis inhibitor|complement lysis inhibitor|complement-associated protein SP-40,40|ku70-binding protein 1|sulfated glycoprotein 2|testosterone-repressed prostate message 2
Super-classes obo:OGG_2060009606c

CCR1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001230
Description

Other designations: C-C CKR-1|C-C chemokine receptor type 1|CC-CKR-1|CCR-1|LD78 receptor|MIP-1alpha-R|RANTES receptor|RANTES-R|macrophage inflammatory protein 1-alpha receptor
Super-classes obo:OGG_2060009606c

CCR3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001232
Description

Other designations: C-C CKR-3|C-C chemokine receptor type 3|CC chemokine receptor 3|CCR-3|b-chemokine receptor|eosinophil CC chemokine receptor 3|eosinophil eotaxin receptor
Super-classes obo:OGG_2060009606c

CCR4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001233
Description

Other designations: C-C CKR-4|C-C chemokine receptor type 4|CCR-4|chemokine (C-C) receptor 4
Super-classes obo:OGG_2060009606c

CCR5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001234
Description

Other designations: C-C chemokine receptor type 5|C-C motif chemokine receptor 5 A159A|HIV-1 fusion coreceptor|chemokine receptor CCR5|chemr13
Super-classes obo:OGG_2060009606c

CCR6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001235
Description

Other designations: C-C chemokine receptor type 6|G protein-coupled receptor 29|G-protein coupled receptor 29|LARC receptor|chemokine (C-C) receptor 6|chemokine receptor-like 3|seven-transmembrane receptor, lymphocyte, 22
Super-classes obo:OGG_2060009606c

CCR7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001236
Description

Other designations: C-C CKR-7|C-C chemokine receptor type 7|CC chemokine receptor 7|CC-CKR-7|CCR-7|EBV-induced G protein-coupled receptor 1|EBV-induced G-protein coupled receptor 1|Epstein-Barr virus induced G-protein coupled receptor|Epstein-Barr virus induced gene 1|MIP-3 beta receptor|chemokine (C-C) receptor 7|epstein-Barr virus-induced G-protein coupled receptor 1|lymphocyte-specific G protein-coupled peptide receptor
Super-classes obo:OGG_2060009606c

CCR8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001237
Description

Other designations: C-C chemokine receptor type 8|CC chemokine receptor 8|CC chemokine receptor CHEMR1|CC-chemokine receptor chemr1|chemokine (C-C) receptor 8|chemokine (C-C) receptor-like 2|chemokine receptor-like 1
Super-classes obo:OGG_2060009606c

COL4A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001284
Description

Other designations: canstatin|collagen alpha-2(IV) chain
Super-classes obo:OGG_2060009606c

KLF6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001316
Description

Other designations: B-cell-derived protein 1|GC-rich binding factor|GC-rich sites-binding factor GBF|Krueppel-like factor 6|Kruppel-like zinc finger protein Zf9|core promoter element binding protein|core promoter element-binding protein|proto-oncogene BCD1|protooncogene B-cell derived 1|suppression of tumorigenicity 12 (prostate)|suppressor of tumorigenicity 12 protein|transcription factor Zf9
Super-classes obo:OGG_2060009606c

COX6B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001340
Description

Other designations: COX VIb-1|cytochrome c oxidase subunit 6B1
Super-classes obo:OGG_2060009606c

CPT1Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001374
Description

carnitine palmitoyltransferase 1
Super-classes obo:OGG_2060009606c

CPT2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001376
Description

Other designations: CPT II|carnitine O-palmitoyltransferase 2, mitochondrial|carnitine palmitoyltransferase II
Super-classes obo:OGG_2060009606c

ATF2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001386
Description

Other designations: activating transcription factor 2 splice variant ATF2-var2|cAMP response element-binding protein CRE-BP1|cAMP responsive element binding protein 2, formerly|cAMP-dependent transcription factor ATF-2|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-2|cyclic AMP-responsive element-binding protein 2|histone acetyltransferase ATF2
Super-classes obo:OGG_2060009606c

ATF6Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001388
Description

Other designations: Creb-related protein|cAMP response element-binding protein-related protein|cAMP responsive element binding protein-like 1|cAMP-dependent transcription factor ATF-6 beta|cAMP-responsive element-binding protein-like 1|cyclic AMP-dependent transcription factor ATF-6 beta|protein G13
Super-classes obo:OGG_2060009606c

CRPc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001401
Description

Other designations: C-reactive protein|pentraxin 1
Super-classes obo:OGG_2060009606c

CTSBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001508
Description

Other designations: APP secretase|amyloid precursor protein secretase|cathepsin B1|cysteine protease
Super-classes obo:OGG_2060009606c

CYP1A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001543
Description

Other designations: CYPIA1|aryl hydrocarbon hydroxylase|cytochrome P1-450, dioxin-inducible|cytochrome P450 1A1|cytochrome P450 form 6|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1|cytochrome P450-C|cytochrome P450-P1|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP1A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001544
Description

Other designations: CYPIA2|P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P(3)450|cytochrome P450 1A2|cytochrome P450 4|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|cytochrome P450-P3|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP1B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001545
Description

Other designations: aryl hydrocarbon hydroxylase|cytochrome P450 1B1|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2A6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001548
Description

Other designations: 1,4-cineole 2-exo-monooxygenase|coumarin 7-hydroxylase|cytochrome P450 2A6|cytochrome P450 IIA3|cytochrome P450(I)|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2A7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001549
Description

Other designations: cytochrome P450 2A7|cytochrome P450 IIA4|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7|cytochrome P450IIA4
Super-classes obo:OGG_2060009606c

CYP3A7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001551
Description

Other designations: aryl hydrocarbon hydroxylase|cytochrome P450 3A7|cytochrome P450, subfamily IIIA, polypeptide 7|cytochrome P450-HFLA|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2A13c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001553
Description

Other designations: cytochrome P450 2A13|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
Super-classes obo:OGG_2060009606c

CYP2B6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001555
Description

Other designations: 1,4-cineole 2-exo-monooxygenase|cytochrome P450 2B6|cytochrome P450 IIB1|cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
Super-classes obo:OGG_2060009606c

CYP2C19c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001557
Description

Other designations: (R)-limonene 6-monooxygenase|(S)-limonene 6-monooxygenase|(S)-limonene 7-monooxygenase|CYPIIC17|CYPIIC19|S-mephenytoin 4-hydroxylase|cytochrome P-450 II C|cytochrome P450 2C19|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19|cytochrome P450-11A|cytochrome P450-254C|flavoprotein-linked monooxygenase|mephenytoin 4'-hydroxylase|mephenytoin 4-hydroxylase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2C8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001558
Description

Other designations: P450 form 1|cytochrome P450 2C8|cytochrome P450 IIC2|cytochrome P450 MP-12|cytochrome P450 MP-20|cytochrome P450 form 1|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase|s-mephenytoin 4-hydroxylase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2C9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001559
Description

Other designations: cytochrome P-450 S-mephenytoin 4-hydroxylase|cytochrome P-450MP|cytochrome P450 2C9|cytochrome P450 PB-1|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2C18c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001562
Description

Other designations: (S)-mephenytoin hydroxylase associated cytochrome P450|CYPIIC18|cytochrome P450 2C18|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18|cytochrome P450-6B/29C|flavoprotein-linked monooxygenase|microsomal monooxygenase|unspecific monooxygenase
Super-classes obo:OGG_2060009606c

CYP2D6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001565
Description

Other designations: cytochrome P450 2D6|cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2|cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2|cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1|cytochrome P450-DB1|debrisoquine 4-hydroxylase|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2E1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001571
Description

Other designations: 4-nitrophenol 2-hydroxylase|CYPIIE1|cytochrome P450 2E1|cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1|cytochrome P450-J|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2F1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001572
Description

Other designations: CYPIIF1|cytochrome P450 2F1|cytochrome P450, subfamily IIF, polypeptide 1|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP2J2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001573
Description

Other designations: CYPIIJ2|arachidonic acid epoxygenase|cytochrome P450 2J2|cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2|flavoprotein-linked monooxygenase|microsomal monooxygenase
Super-classes obo:OGG_2060009606c

CYP3A4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001576
Description

Other designations: 1,8-cineole 2-exo-monooxygenase|P450-III, steroid inducible|albendazole monooxygenase|albendazole sulfoxidase|cytochrome P450 3A3|cytochrome P450 3A4|cytochrome P450 HLp|cytochrome P450 NF-25|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450-PCN1|glucocorticoid-inducible P450|nifedipine oxidase|quinine 3-monooxygenase|taurochenodeoxycholate 6-alpha-hydroxylase
Super-classes obo:OGG_2060009606c

CYP3A5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001577
Description

Other designations: aryl hydrocarbon hydroxylase|cytochrome P450 3A5|cytochrome P450 HLp2|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5|cytochrome P450-PCN3|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Super-classes obo:OGG_2060009606c

CYP4A11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001579
Description

Other designations: 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVA11|P450HL-omega|alkane-1 monooxygenase|cytochrome P-450HK-omega|cytochrome P450 4A11|cytochrome P450, subfamily IVA, polypeptide 11|cytochrome P450HL-omega|fatty acid omega-hydroxylase|lauric acid omega-hydroxylase
Super-classes obo:OGG_2060009606c

CYP4B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001580
Description

Other designations: cytochrome P450 4B1|cytochrome P450, subfamily IVB, polypeptide 1|cytochrome P450-HP|microsomal monooxygenase
Super-classes obo:OGG_2060009606c

CYP7A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001581
Description

Other designations: cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cytochrome P450 7A1|cytochrome P450, subfamily VIIA polypeptide 1
Super-classes obo:OGG_2060009606c

CYP8B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001582
Description

Other designations: 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1|sterol 12-alpha-hydroxylase
Super-classes obo:OGG_2060009606c

CYP11A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001583
Description

Other designations: cholesterol 20-22 desmolase|cholesterol monooxygenase (side-chain cleaving)|cholesterol side-chain cleavage enzyme, mitochondrial|cytochrome P450 11A1|cytochrome P450(scc)|cytochrome P450, subfamily XIA (cholesterol side chain cleavage)|cytochrome P450C11A1|steroid 20-22-lyase
Super-classes obo:OGG_2060009606c

CYP11B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001584
Description

Other designations: CYPXIB1|cytochrome P-450c11|cytochrome P450 11B1, mitochondrial|cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1|cytochrome P450C11|cytochrome p450 XIB1|steroid 11-beta-hydroxylase|steroid 11-beta-monooxygenase
Super-classes obo:OGG_2060009606c

CYP11B2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001585
Description

Other designations: aldosterone synthase|aldosterone-synthesizing enzyme|cytochrome P-450Aldo|cytochrome P-450C18|cytochrome P450 11B2, mitochondrial|cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2|mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2|steroid 11-beta-monooxygenase|steroid 11-beta/18-hydroxylase|steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Super-classes obo:OGG_2060009606c

CYP17A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001586
Description

Other designations: 17-alpha-hydroxyprogesterone aldolase|CYPXVII|cytochrome P450 17A1|cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia|cytochrome P450-C17|cytochrome P450c17|cytochrome p450 XVIIA1|steroid 17-alpha-hydroxylase/17,20 lyase|steroid 17-alpha-monooxygenase
Super-classes obo:OGG_2060009606c

CYP19A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001588
Description

Other designations: aromatase|cytochrome P-450AROM|cytochrome P450 19A1|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthase|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase
Super-classes obo:OGG_2060009606c

CYP21A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001589
Description

Other designations: 21-OHase|cytochrome P450 XXI|cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2|cytochrome P450-C21B|steroid 21-hydroxylase|steroid 21-monooxygenase
Super-classes obo:OGG_2060009606c

CYP24A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001591
Description

Other designations: 1,25-@dihydroxyvitamin D3 24-hydroxylase|1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial|24-OHase|cytochrome P450 24A1|cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)|cytochrome P450-CC24|exo-mitochondrial protein|vitamin D 24-hydroxylase|vitamin D(3) 24-hydroxylase
Super-classes obo:OGG_2060009606c

CYP26A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001592
Description

Other designations: P450, retinoic acid-inactivating, 1|cytochrome P450 26A1|cytochrome P450 retinoic acid-inactivating 1|cytochrome P450, subfamily XXVIA, polypeptide 1|cytochrome P450RAI|hP450RAI|retinoic acid 4-hydroxylase|retinoic acid-metabolizing cytochrome
Super-classes obo:OGG_2060009606c

CYP27A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001593
Description

Other designations: 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase|5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase|5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase|cholestanetriol 26-monooxygenase|cytochrome P-450C27/25|cytochrome P450 27|cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1|sterol 26-hydroxylase, mitochondrial|sterol 27-hydroxylase|vitamin D(3) 25-hydroxylase
Super-classes obo:OGG_2060009606c

CYP27B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001594
Description

Other designations: 1alpha(OH)ase|25 hydroxyvitamin D3-1-alpha hydroxylase|25-OHD-1 alpha-hydroxylase|25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial|VD3 1A hydroxylase|calcidiol 1-monooxygenase|cytochrome P450 subfamily XXVIIB polypeptide 1|cytochrome P450C1 alpha|cytochrome P450VD1-alpha|cytochrome p450 27B1
Super-classes obo:OGG_2060009606c

CYP51A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001595
Description

Other designations: CYPLI|cytochrome P450 51A1|cytochrome P450, 51 (lanosterol 14-alpha-demethylase)|cytochrome P450-14DM|cytochrome P45014DM|cytochrome P450LI|lanosterol 14-alpha demethylase|lanosterol 14-alpha-demethylase|sterol 14-alpha demethylase
Super-classes obo:OGG_2060009606c

DAB2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001601
Description

Other designations: differentially-expressed protein 2|disabled homolog 2|disabled homolog 2, mitogen-responsive phosphoprotein
Super-classes obo:OGG_2060009606c

GADD45Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001647
Description

Other designations: DDIT-1|DNA damage-inducible transcript 1 protein|DNA damage-inducible transcript-1|DNA-damage-inducible transcript 1|growth arrest and DNA damage-inducible protein GADD45 alpha|growth arrest and DNA-damage-inducible 45 alpha
Super-classes obo:OGG_2060009606c

DDIT3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001649
Description

DNA-damage-inducible transcript 3
Super-classes obo:OGG_2060009606c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001649c

DDX6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001656
Description

Other designations: ATP-dependent RNA helicase p54|DEAD (Asp-Glu-Ala-Asp) box polypeptide 6|DEAD box protein 6|DEAD box-6|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)|oncogene RCK|probable ATP-dependent RNA helicase DDX6
Super-classes obo:OGG_2060009606c

DHFRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001719
Description

dihydrofolate reductase
Super-classes obo:OGG_2060009606c

NQO1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001728
Description

Other designations: DT-diaphorase|NAD(P)H dehydrogenase [quinone] 1|NAD(P)H:Quinone acceptor oxidoreductase type 1|NAD(P)H:menadione oxidoreductase 1|NAD(P)H:quinone oxidoreductase 1|NAD(P)H:quinone oxireductase|azoreductase|diaphorase (NADH/NADPH) (cytochrome b-5 reductase)|diaphorase-4|dioxin-inducible 1|menadione reductase|phylloquinone reductase|quinone reductase 1
Super-classes obo:OGG_2060009606c

DPYDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001806
Description

Other designations: dihydropyrimidine dehydrogenase [NADP(+)]|dihydrothymine dehydrogenase|dihydrouracil dehydrogenase
Super-classes obo:OGG_2060009606c

TSC22D3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001831
Description

Other designations: DSIP-immunoreactive leucine zipper protein|DSIP-immunoreactive peptide|TSC-22 related protein|TSC-22-like protein|TSC-22-related protein|TSC22 domain family protein 3|delta sleep inducing peptide, immunoreactor|delta sleep-inducing peptide immunoreactor|glucocorticoid-induced leucine zipper protein
Super-classes obo:OGG_2060009606c

ECM2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001842
Description

Other designations: extracellular matrix protein 2|matrix glycoprotein SC1/ECM2
Super-classes obo:OGG_2060009606c

ECH1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001891
Description

Other designations: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial|delta3,5-delta2,4-dienoyl-CoA isomerase|dienoyl-CoA isomerase|enoyl Coenzyme A hydratase 1, peroxisomal|peroxisomal enoyl-CoA hydratase 1
Super-classes obo:OGG_2060009606c

EDN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001906
Description

Other designations: endothelin-1|preproendothelin-1
Super-classes obo:OGG_2060009606c

EIF2Dc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001939
Description

Other designations: hepatocellular carcinoma-associated antigen 56|ligatin
Super-classes obo:OGG_2060009606c

EGFc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001950
Description

Other designations: beta-urogastrone|pro-epidermal growth factor
Super-classes obo:OGG_2060009606c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c

EGFRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001956
Description

Other designations: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|proto-oncogene c-ErbB-1|receptor tyrosine-protein kinase erbB-1
Super-classes obo:OGG_2060009606c

EGR1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001958
Description

Other designations: EGR-1|early growth response protein 1|nerve growth factor-induced protein A|transcription factor ETR103|transcription factor Zif268|zinc finger protein 225|zinc finger protein Krox-24
Super-classes obo:OGG_2060009606c

EHHADHc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001962
Description

Other designations: 3,2-trans-enoyl-CoA isomerase|L-3-hydroxyacyl-CoA dehydrogenase|L-bifunctional protein, peroxisomal|PBE|enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase|peroxisomal bifunctional enzyme|peroxisomal enoyl-CoA hydratase
Super-classes obo:OGG_2060009606c

EIF1AXc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001964
Description

Other designations: Putative eukaryotic translation initiation factor 1A|eIF-1A X isoform|eukaryotic translation initiation factor 1A, X chromosome|eukaryotic translation initiation factor 1A, X-chromosomal|eukaryotic translation initiation factor 4C
Super-classes obo:OGG_2060009606c

EIF2S1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001965
Description

Other designations: eIF-2-alpha|eukaryotic translation initiation factor 2 subunit 1|eukaryotic translation initiation factor 2 subunit alpha
Super-classes obo:OGG_2060009606c

EIF2B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001967
Description

Other designations: eIF-2B GDP-GTP exchange factor subunit alpha|translation initiation factor eIF-2B subunit alpha
Super-classes obo:OGG_2060009606c

EIF2S3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001968
Description

Other designations: eIF-2-gamma X|eIF-2gX|eukaryotic translation initiation factor 2 subunit 3|eukaryotic translation initiation factor 2 subunit gamma X|eukaryotic translation initiation factor 2G
Super-classes obo:OGG_2060009606c

EIF4A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001973
Description

Other designations: ATP-dependent RNA helicase eIF4A-1|eukaryotic initiation factor 4A-I|eukaryotic initiation factor 4AI|eukaryotic translation initiation factor 4A
Super-classes obo:OGG_2060009606c

EIF4A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001974
Description

Other designations: ATP-dependent RNA helicase eIF4A-2|eukaryotic initiation factor 4A-II|eukaryotic translation initiation factor 4A
Super-classes obo:OGG_2060009606c

EIF4Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001975
Description

eukaryotic translation initiation factor 4B
Super-classes obo:OGG_2060009606c

EIF4Ec # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001977
Description

Other designations: eIF-4E|eIF-4F 25 kDa subunit|eukaryotic translation initiation factor 4E-like 1|mRNA cap-binding protein
Super-classes obo:OGG_2060009606c

EIF4EBP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001978
Description

Other designations: eIF4E-binding protein 1|eukaryotic translation initiation factor 4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
Super-classes obo:OGG_2060009606c

EIF4EBP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001979
Description

Other designations: 4E-BP2|eIF4E-binding protein 2|eukaryotic translation initiation factor 4E-binding protein 2|phosphorylated, heat and acid stable regulated by insulin protein II
Super-classes obo:OGG_2060009606c

EIF4G1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001981
Description

Other designations: EIF4-gamma|eIF-4-gamma 1|eucaryotic translation initiation factor 4G|eukaryotic translation initiation factor 4 gamma 1
Super-classes obo:OGG_2060009606c

EIF4G2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001982
Description

Other designations: DAP-5|aging-associated protein 1|death-associated protein 5|eIF-4-gamma 2|eIF-4G 2|eIF4G 2|eukaryotic translation initiation factor 4 gamma 2|eukaryotic translation initiation factor 4G-like 1
Super-classes obo:OGG_2060009606c

EIF5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001983
Description

eukaryotic translation initiation factor 5
Super-classes obo:OGG_2060009606c

EIF5Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001984
Description

Other designations: eIF-4D|eIF-5A-1|eIF-5A1|eukaryotic initiation factor 5A|eukaryotic translation initiation factor 5A-1|rev-binding factor
Super-classes obo:OGG_2060009606c

ELAVL4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000001996
Description

Other designations: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)|ELAV-like protein 4|Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4|Hu antigen D|hu-antigen D|paraneoplastic encephalomyelitis antigen HuD
Super-classes obo:OGG_2060009606c

ERN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002081
Description

Other designations: ER to nucleus signalling 1|endoplasmic reticulum-to-nucleus signaling 1|inositol-requiring 1|inositol-requiring enzyme 1|inositol-requiring protein 1|ire1-alpha|protein kinase/endoribonuclease|serine/threonine-protein kinase/endoribonuclease IRE1
Super-classes obo:OGG_2060009606c

ETS2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002114
Description

Other designations: oncogene ETS-2|protein C-ets-2|v-ets avian erythroblastosis virus E2 oncogene homolog 2|v-ets erythroblastosis virus E26 oncogene homolog 2
Super-classes obo:OGG_2060009606c

FAAHc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002166
Description

Other designations: anandamide amidohydrolase 1|fatty-acid amide hydrolase 1|oleamide hydrolase 1
Super-classes obo:OGG_2060009606c

FABP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002168
Description

Other designations: fatty acid-binding protein 1|fatty acid-binding protein, liver|liver-type fatty acid-binding protein
Super-classes obo:OGG_2060009606c

FABP5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002171
Description

Other designations: epidermal-type fatty acid-binding protein|fatty acid-binding protein, epidermal|psoriasis-associated fatty acid-binding protein homolog
Super-classes obo:OGG_2060009606c

FAT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002195
Description

Other designations: FAT tumor suppressor 1|FAT tumor suppressor homolog 1|cadherin ME5|cadherin family member 7|cadherin-related family member 8|cadherin-related tumor suppressor homolog|protein fat homolog|protocadherin Fat 1
Super-classes obo:OGG_2060009606c

MS4A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002206
Description

Other designations: Fc fragment of IgE, high affinity I, receptor for; beta polypeptide|High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)|high affinity IgE receptor beta subunit|high affinity immunoglobulin epsilon receptor subunit beta|igE Fc receptor subunit beta|immunoglobulin E receptor, high affinity, beta polypeptide
Super-classes obo:OGG_2060009606c

FEN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002237
Description

Other designations: DNase IV|flap endonuclease 1|maturation factor 1|maturation factor-1
Super-classes obo:OGG_2060009606c

FGF2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002247
Description

Other designations: basic fibroblast growth factor bFGF|fibroblast growth factor 2|heparin-binding growth factor 2|prostatropin
Super-classes obo:OGG_2060009606c

FGF14c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002259
Description

Other designations: bA397O8.2|fibroblast growth factor homologous factor 4
Super-classes obo:OGG_2060009606c

FHITc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002272
Description

Other designations: AP3A hydrolase|bis(5'-adenosyl)-triphosphatase|diadenosine 5',5'''-P1,P3-triphosphate hydrolase|dinucleosidetriphosphatase|tumor suppressor protein
Super-classes obo:OGG_2060009606c

FOXO1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002308
Description

Other designations: forkhead box protein O1|forkhead box protein O1A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma
Super-classes obo:OGG_2060009606c

FN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002335
Description

Other designations: cold-insoluble globulin|fibronectin|migration-stimulating factor
Super-classes obo:OGG_2060009606c

FNTAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002339
Description

Other designations: FTase-alpha|GGTase-I-alpha|farnesyl-protein transferase alpha-subunit|protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha|protein prenyltransferase alpha subunit repeat containing 2|ras proteins prenyltransferase subunit alpha|type I protein geranyl-geranyltransferase alpha subunit
Super-classes obo:OGG_2060009606c

NR5A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002494
Description

Other designations: CYP7A promoter-binding factor|alpha-1-fetoprotein transcription factor|b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus|fetoprotein-alpha 1 (AFP) transcription factor|hepatocytic transcription factor hB1F-3|liver nuclear receptor homolog-1 variant 2|liver receptor homolog 1|liver receptor homolog-1|nuclear receptor NR5A2|nuclear receptor subfamily 5 group A member 2
Super-classes obo:OGG_2060009606c

G6PCc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002538
Description

Other designations: G-6-Pase|G6Pase|G6Pase-alpha|glucose-6-phosphatase|glucose-6-phosphatase alpha
Super-classes obo:OGG_2060009606c

G6PDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002539
Description

Other designations: glucose-6-phosphate 1-dehydrogenase
Super-classes obo:OGG_2060009606c

GAB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002549
Description

Other designations: GRB2-associated binder 1|GRB2-associated-binding protein 1|growth factor receptor bound protein 2-associated protein 1
Super-classes obo:OGG_2060009606c

GABPAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002551
Description

Other designations: GA binding protein transcription factor alpha subunit 60kDa|GA-binding protein alpha chain|GABP subunit alpha|human nuclear respiratory factor-2 subunit alpha|nuclear respiratory factor 2 alpha subunit|nuclear respiratory factor 2 subunit alpha|transcription factor E4TF1-60
Super-classes obo:OGG_2060009606c

GAS1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002619
Description

Other designations: GAS-1|Growth arrest-specific gene-1|growth arrest-specific protein 1
Super-classes obo:OGG_2060009606c

GFPT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002673
Description

Other designations: D-fructose-6-phosphate amidotransferase 1|glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1|glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1|glutamine:fructose-6-phosphate amidotransferase 1|hexosephosphate aminotransferase 1
Super-classes obo:OGG_2060009606c

GFRA1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002674
Description

Other designations: GDNF family receptor alpha-1|GDNF receptor alpha-1|GDNFR-alpha-1|GPI-linked anchor protein|Glial cell line-derived neurotrophic factor receptor alpha|PI-linked cell-surface accessory protein|RET ligand 1|TGF-beta related neurotrophic factor receptor 1|TGF-beta-related neurotrophic factor receptor 1
Super-classes obo:OGG_2060009606c

GCLCc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002729
Description

glutamate-cysteine ligase catalytic subunit
Super-classes obo:OGG_2060009606c

GCLMc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002730
Description

glutamate-cysteine ligase, modifier subunit
Super-classes obo:OGG_2060009606c

GPC1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002817
Description

Other designations: glypican proteoglycan 1|glypican-1
Super-classes obo:OGG_2060009606c

CCR10c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002826
Description

Other designations: C-C CKR-10|C-C chemokine receptor type 10|CC chemokine receptor 10|CC-CKR-10|CCR-10|G protein-coupled receptor 2|G-protein coupled receptor 2
Super-classes obo:OGG_2060009606c

CXCR3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002833
Description

Other designations: C-X-C chemokine receptor type 3|CXC-R3|CXCR-3|G protein-coupled receptor 9|IP-10 receptor|IP10 receptor|Mig receptor|chemokine (C-X-C) receptor 3|interferon-inducible protein 10 receptor
Super-classes obo:OGG_2060009606c

GPR39c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002863
Description

Other designations: G-protein coupled receptor 39
Super-classes obo:OGG_2060009606c

GPX2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002877
Description

Other designations: gastrointestinal glutathione peroxidase|glutathione peroxidase 2|glutathione peroxidase-related protein 2
Super-classes obo:OGG_2060009606c

NR3C1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002908
Description

Other designations: glucocorticoid nuclear receptor variant 1|glucocorticoid receptor
Super-classes obo:OGG_2060009606c

GRM8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002918
Description

Other designations: metabotropic glutamate receptor 8
Super-classes obo:OGG_2060009606c

GSSc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002937
Super-classes obo:OGG_2060009606c

GSTA3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002940
Description

Other designations: GST class-alpha member 3|S-(hydroxyalkyl)glutathione lyase A3|glutathione S-alkyltransferase A3|glutathione S-aralkyltransferase A3|glutathione S-aryltransferase A3|glutathione S-transferase A3|glutathione S-transferase A3-3
Super-classes obo:OGG_2060009606c

GSTM3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000002947
Description

Other designations: GST class-mu 3|S-(hydroxyalkyl)glutathione lyase M3|brain GST|brain type mu-glutathione S-transferase|glutathione S-alkyltransferase M3|glutathione S-aralkyltransferase M3|glutathione S-aryltransferase M3|glutathione S-transferase M3 (brain)|glutathione S-transferase Mu 3|glutathione S-transferase, Mu-3|hGSTM3-3
Super-classes obo:OGG_2060009606c

H3F3Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003021
Description

Other designations: H3 histone, family 3A|histone H3.3
Super-classes obo:OGG_2060009606c

HADHBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003032
Description

Other designations: 2-enoyl-Coenzyme A (CoA) hydratase, beta subunit|3-ketoacyl-Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein, beta subunit|acetyl-CoA acyltransferase|beta-ketothiolase|hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit|trifunctional enzyme subunit beta, mitochondrial
Super-classes obo:OGG_2060009606c

HCKc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003055
Description

Other designations: hematopoietic cell kinase|p59-HCK/p60-HCK|tyrosine-protein kinase HCK
Super-classes obo:OGG_2060009606c

NRG1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003084
Description

Other designations: MSTP131|glial growth factor|heregulin, alpha (45kD, ERBB2 p185-activator)|neu differentiation factor|neuregulin 1 type IV beta 1a|neuregulin 1 type IV beta 3|pro-NRG1|pro-neuregulin-1, membrane-bound isoform|sensory and motor neuron derived factor
Super-classes obo:OGG_2060009606c

HLA-DPB2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003116
Description

major histocompatibility complex, class II, DP beta 2 (pseudogene)
Super-classes obo:OGG_2070009606c

HMGCS1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003157
Description

Other designations: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase|3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)|hydroxymethylglutaryl-CoA synthase, cytoplasmic
Super-classes obo:OGG_2060009606c

HMGCS2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003158
Description

Other designations: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)|HMG-CoA synthase|hydroxymethylglutaryl-CoA synthase, mitochondrial
Super-classes obo:OGG_2060009606c

HMGA1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003159
Description

Other designations: HMG-I(Y)|high mobility group protein A1|high mobility group protein HMG-I/HMG-Y|high mobility group protein R|high-mobility group (nonhistone chromosomal) protein isoforms I and Y|nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
Super-classes obo:OGG_2060009606c

HMMRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003161
Description

Other designations: hyaluronan mediated motility receptor|intracellular hyaluronic acid-binding protein|receptor for hyaluronan-mediated motility
Super-classes obo:OGG_2060009606c

HMOX1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003162
Description

Other designations: heat shock protein, 32-kD|heme oxygenase 1
Super-classes obo:OGG_2060009606c

SLC29A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003177
Description

Other designations: 36 kDa nucleolar protein HNP36|delayed-early response protein 12|equilibrative NBMPR-insensitive nucleoside transporter|equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter|equilibrative nucleoside transporter 2|hydrophobic nucleolar protein, 36 kDa|hydrophobic nucleolar protein, 36kD|nucleoside transporter, ei-type|solute carrier family 29 (nucleoside transporters), member 2|solute carrier family 29 member 2
Super-classes obo:OGG_2060009606c

HNRNPABc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003182
Description

Other designations: ABBP-1|APOBEC1-binding protein 1|apobec-1 binding protein 1|apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1-binding protein 1|hnRNP A/B|hnRNP type A/B protein
Super-classes obo:OGG_2060009606c

DNAJB2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003300
Description

Other designations: dnaJ homolog subfamily B member 2|dnaJ protein homolog 1|heat shock 40 kDa protein 3|heat shock protein J1|heat shock protein, neuronal DNAJ-like 1
Super-classes obo:OGG_2060009606c

HSPA5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003309
Description

Other designations: 78 kDa glucose-regulated protein|endoplasmic reticulum lumenal Ca(2+)-binding protein grp78|epididymis secretory sperm binding protein Li 89n|immunoglobulin heavy chain-binding protein
Super-classes obo:OGG_2060009606c

DNAJB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003337
Description

Other designations: DnaJ (Hsp40) homolog, subfmaily B, member 1|dnaJ homolog subfamily B member 1|dnaJ protein homolog 1|hDj-1|heat shock 40 kDa protein 1|heat shock 40kD protein 1|heat shock protein 40|human DnaJ protein 1|radial spoke 16 homolog B
Super-classes obo:OGG_2060009606c

DNAJC4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003338
Description

Other designations: dnaJ homolog subfamily C member 4|dnaJ-like protein HSPF2|heat shock 40kD protein 2|multiple endocrine neoplasia type 1 candidate protein number 18
Super-classes obo:OGG_2060009606c

HSPG2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003339
Description

Other designations: basement membrane-specific heparan sulfate proteoglycan core protein|endorepellin (domain V region)|perlecan proteoglycan
Super-classes obo:OGG_2060009606c

IGFBP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003484
Description

Other designations: IBP-1|IGF-binding protein 1|IGFBP-1|alpha-pregnancy-associated endometrial globulin|amniotic fluid binding protein|binding protein-25|binding protein-26|binding protein-28|growth hormone independent-binding protein|insulin-like growth factor-binding protein 1|placental protein 12
Super-classes obo:OGG_2060009606c

IGFBP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003485
Description

Other designations: IBP-2|IGF-binding protein 2|IGFBP-2|insulin-like growth factor-binding protein 2
Super-classes obo:OGG_2060009606c

IGFBP3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003486
Description

Other designations: IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3
Super-classes obo:OGG_2060009606c

IGFBP4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003487
Description

Other designations: IBP-4|IGF-binding protein 4|insulin-like growth factor-binding protein 4
Super-classes obo:OGG_2060009606c

IGFBP5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003488
Description

Other designations: IBP-5|IGF-binding protein 5|IGFBP-5|insulin-like growth factor-binding protein 5
Super-classes obo:OGG_2060009606c

IGFBP6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003489
Description

Other designations: IBP-6|IGF binding protein 6|IGF-binding protein 6|IGFBP-6|insulin-like growth factor-binding protein 6
Super-classes obo:OGG_2060009606c

IGFBP7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003490
Description

Other designations: IGF-binding protein 7|IGFBP-rP1|PGI2-stimulating factor|angiomodulin|insulin-like growth factor-binding protein 7|prostacyclin-stimulating factor|tumor-derived adhesion factor
Super-classes obo:OGG_2060009606c

CYR61c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003491
Description

Other designations: CCN family member 1|IBP-10|IGF-binding protein 10|IGFBP-10|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61|insulin-like growth factor-binding protein 10|protein CYR61
Super-classes obo:OGG_2060009606c

IKBKBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003551
Description

Other designations: I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta
Super-classes obo:OGG_2060009606c

IL1Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003552
Description

Other designations: IL-1 alpha|hematopoietin-1|interleukin-1 alpha|preinterleukin 1 alpha|pro-interleukin-1-alpha
Super-classes obo:OGG_2060009606c

IL1Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003553
Description

Other designations: IL-1 beta|catabolin|interleukin-1 beta|preinterleukin 1 beta|pro-interleukin-1-beta
Super-classes obo:OGG_2060009606c

IL2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003558
Description

Other designations: T cell growth factor|aldesleukin|interleukin-2|involved in regulation of T-cell clonal expansion
Super-classes obo:OGG_2060009606c

IL2RBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003560
Description

Other designations: CD122 antigen|IL-2 receptor subunit beta|IL-2R subunit beta|IL-2RB|high affinity IL-2 receptor beta subunit|high affinity IL-2 receptor subunit beta|interleukin 15 receptor, beta|interleukin-2 receptor subunit beta|p75
Super-classes obo:OGG_2060009606c

IL4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003565
Description

Other designations: B cell growth factor 1|B_cell stimulatory factor 1|binetrakin|interleukin 4 variant 2|interleukin-4|lymphocyte stimulatory factor 1|pitrakinra
Super-classes obo:OGG_2060009606c

IL6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003569
Description

Other designations: B-cell differentiation factor|B-cell stimulatory factor 2|BSF-2|CDF|CTL differentiation factor|IFN-beta-2|hybridoma growth factor|interferon beta-2|interferon, beta 2|interleukin 6 (interferon, beta 2)|interleukin BSF-2|interleukin-6
Super-classes obo:OGG_2060009606c

IL10c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003586
Description

Other designations: T-cell growth inhibitory factor|cytokine synthesis inhibitory factor|interleukin-10
Super-classes obo:OGG_2060009606c

IL12Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003592
Description

Other designations: CLMF p35|IL-12, subunit p35|IL35 subunit|NF cell stimulatory factor chain 1|NK cell stimulatory factor chain 1|cytotoxic lymphocyte maturation factor 1, p35|cytotoxic lymphocyte maturation factor 35 kDa subunit|interleukin 12, p35|interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)|interleukin-12 alpha chain|interleukin-12 subunit alpha
Super-classes obo:OGG_2060009606c

TNFRSF9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003604
Description

Other designations: 4-1BB ligand receptor|CD137 antigen|T cell antigen ILA|T-cell antigen 4-1BB homolog|T-cell antigen ILA|homolog of mouse 4-1BB|induced by lymphocyte activation (ILA)|interleukin-activated receptor, homolog of mouse Ly63|receptor protein 4-1BB|tumor necrosis factor receptor superfamily member 9
Super-classes obo:OGG_2060009606c

INSIG1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003638
Description

Other designations: INSIG-1 membrane protein|insulin-induced gene 1 protein
Super-classes obo:OGG_2060009606c

EIF3Ec # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003646
Description

Other designations: eIF-3 p48|eukaryotic translation initiation factor 3 subunit 6|eukaryotic translation initiation factor 3 subunit E|eukaryotic translation initiation factor 3, subunit 6 (48kD)|eukaryotic translation initiation factor 3, subunit 6 48kDa|mammary tumor-associated protein INT6|murine mammary tumor integration site 6 (oncogene homolog)|viral integration site protein INT-6 homolog
Super-classes obo:OGG_2060009606c

IRF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003659
Description

Other designations: interferon regulatory factor 1 isoform d78
Super-classes obo:OGG_2060009606c

ITGB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003688
Description

Other designations: glycoprotein IIa|integrin VLA-4 beta subunit|integrin beta-1|very late activation protein, beta polypeptide
Super-classes obo:OGG_2060009606c

ITGB3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003690
Description

Other designations: integrin beta-3|platelet membrane glycoprotein IIIa
Super-classes obo:OGG_2060009606c

EIF6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003692
Description

Other designations: B4 integrin interactor|eukaryotic translation initiation factor 3A|p27 beta-4 integrin-binding protein
Super-classes obo:OGG_2060009606c

JUNc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003725
Description

Other designations: Jun activation domain binding protein|activator protein 1|enhancer-binding protein AP1|jun oncogene|p39|proto-oncogene c-Jun|transcription factor AP-1|v-jun avian sarcoma virus 17 oncogene homolog|v-jun sarcoma virus 17 oncogene homolog
Super-classes obo:OGG_2060009606c

JUNBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003726
Description

Other designations: activator protein 1|transcription factor jun-B
Super-classes obo:OGG_2060009606c

JUNDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003727
Description

Other designations: JunD-FL isoform|activator protein 1|transcription factor jun-D
Super-classes obo:OGG_2060009606c

KCNMA1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003778
Description

Other designations: BK channel alpha subunit|BKCA alpha subunit|calcium-activated potassium channel subunit alpha-1|calcium-activated potassium channel, subfamily M subunit alpha-1|hSlo|k(VCA)alpha|maxi-K channel HSLO|slo homolog|slowpoke homolog|stretch-activated Kca channel
Super-classes obo:OGG_2060009606c

KIFC1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003833
Description

Other designations: kinesin-like 2|kinesin-like protein 2|kinesin-like protein KIFC1|kinesin-related protein HSET
Super-classes obo:OGG_2060009606c

LGALS1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000003956
Description

Other designations: 14 kDa laminin-binding protein|14 kDa lectin|HBL|HLBP14|HPL|S-Lac lectin 1|beta-galactoside-binding lectin L-14-I|beta-galactoside-binding protein 14kDa|gal-1|galaptin|galectin 1|galectin-1|lactose-binding lectin 1|putative MAPK-activating protein PM12
Super-classes obo:OGG_2060009606c

LMNB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004001
Description

Other designations: lamin-B1
Super-classes obo:OGG_2060009606c

LPAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004018
Description

Other designations: antiangiogenic AK38 protein|apo(a)|apolipoprotein(a)|lp(a)
Super-classes obo:OGG_2060009606c

LPLc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004023
Description

LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
Super-classes obo:OGG_2060009606c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004023c

LSSc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004047
Description

Other designations: 2,3-epoxysqualene--lanosterol cyclase|2,3-epoxysqualene-lanosterol cyclase|hOSC|lanosterol synthase|oxidosqualene--lanosterol cyclase
Super-classes obo:OGG_2060009606c

CYP4F3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004051
Description

Other designations: CYPIVF3|cytochrome P-450|cytochrome P450 4F3|cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)|cytochrome P450-LTB-omega|leukotriene B4 omega hydroxylase|leukotriene-B(4) 20-monooxygenase 2|leukotriene-B(4) omega-hydroxylase 2|leukotriene-B4 20-monooxygenase
Super-classes obo:OGG_2060009606c

DNAJB9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004189
Description

Other designations: ER-resident protein ERdj4|dnaJ homolog subfamily B member 9|endoplasmic reticulum DNA J domain-containing protein 4|endoplasmic reticulum DnaJ homolog 4|microvascular endothelial differentiation gene 1 protein
Super-classes obo:OGG_2060009606c

MDM2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004193
Description

Other designations: E3 ubiquitin-protein ligase Mdm2|Mdm2, p53 E3 ubiquitin protein ligase homolog|Mdm2, transformed 3T3 cell double minute 2, p53 binding protein|double minute 2, human homolog of; p53-binding protein|oncoprotein Mdm2
Super-classes obo:OGG_2060009606c

ME1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004199
Description

Other designations: Malic enzyme, cytoplasmic|NADP-ME|NADP-dependent malic enzyme|malate dehydrogenase|malic enzyme 1, soluble|pyruvic-malic carboxylase
Super-classes obo:OGG_2060009606c

MGST1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004257
Description

microsomal glutathione S-transferase 1
Super-classes obo:OGG_2060009606c

MGST2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004258
Description

microsomal glutathione S-transferase 2
Super-classes obo:OGG_2060009606c

MGST3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004259
Description

microsomal glutathione S-transferase 3
Super-classes obo:OGG_2060009606c

MMP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004313
Description

Other designations: 72 kDa gelatinase|72 kDa type IV collagenase|MMP-2|collagenase type IV-A|gelatinase A|matrix metalloproteinase-2|matrix metalloproteinase-II|neutrophil gelatinase
Super-classes obo:OGG_2060009606c

MMP9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004318
Description

Other designations: 92 kDa gelatinase|92 kDa type IV collagenase|macrophage gelatinase|matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)|matrix metalloproteinase-9|type V collagenase
Super-classes obo:OGG_2060009606c

CD200c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004345
Description

Other designations: CD200 antigen|MRC OX-2 antigen|OX-2 membrane glycoprotein|antigen identified by monoclonal antibody MRC OX-2
Super-classes obo:OGG_2060009606c

MYBL2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004605
Description

Other designations: myb-like protein 2|myb-related protein B|v-myb myeloblastosis viral oncogene homolog-like 2
Super-classes obo:OGG_2060009606c

MYCc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004609
Description

Other designations: avian myelocytomatosis viral oncogene homolog|class E basic helix-loop-helix protein 39|myc proto-oncogene protein|myc-related translation/localization regulatory factor|proto-oncogene c-Myc|transcription factor p64|v-myc myelocytomatosis viral oncogene homolog
Super-classes obo:OGG_2060009606c

MYCNc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004613
Description

Other designations: N-myc proto-oncogene protein|class E basic helix-loop-helix protein 37|neuroblastoma MYC oncogene|neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene|oncogene NMYC|pp65/67
Super-classes obo:OGG_2060009606c

GADD45Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004616
Description

Other designations: growth arrest and DNA damage-inducible protein GADD45 beta|myeloid differentiation primary response protein MyD118|negative growth regulatory protein MyD118
Super-classes obo:OGG_2060009606c

NAP1L1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004673
Description

Other designations: HSP22-like protein interacting protein|NAP-1 related protein|NAP-1-related protein|hNRP
Super-classes obo:OGG_2060009606c

NEFLc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004747
Description

Other designations: light molecular weight neurofilament protein|neurofilament light polypeptide|neurofilament protein, light chain|neurofilament subunit NF-L|neurofilament triplet L protein|neurofilament, light polypeptide 68kDa
Super-classes obo:OGG_2060009606c

NF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004763
Description

Other designations: neurofibromatosis-related protein NF-1|neurofibromin
Super-classes obo:OGG_2060009606c

NFE2L2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004780
Description

abhydrolase domain containing 1
Super-classes obo:OGG_2060009606c

NFKB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004790
Description

Other designations: DNA binding factor KBF1|DNA-binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p105 subunit|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit
Super-classes obo:OGG_2060009606c

NFKB2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004791
Description

Other designations: DNA-binding factor KBF2|NFKB, p52/p100 subunit|lymphocyte translocation chromosome 10 protein|nuclear factor Kappa-B, subunit 2|nuclear factor NF-kappa-B p100 subunit|nuclear factor of Kappa light chain gene enhancer in B cells 2|oncogene Lyt-10|transcription factor NFKB2
Super-classes obo:OGG_2060009606c

NME1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004830
Description

Other designations: NDP kinase A|granzyme A-activated DNase|metastasis inhibition factor nm23|non-metastatic cells 1, protein (NM23A) expressed in|nucleoside diphosphate kinase A|tumor metastatic process-associated protein
Super-classes obo:OGG_2060009606c

NUCB2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000004925
Description

Other designations: DNA-binding protein NEFA|epididymis secretory protein Li 109|gastric cancer antigen Zg4|nesfatin-1|nucleobindin-2|nucleobinding 2|prepronefastin|prepronesfatin
Super-classes obo:OGG_2060009606c

OXTRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005021
Description

oxytocin receptor
Super-classes obo:OGG_2060009606c

P4HBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005034
Description

Other designations: cellular thyroid hormone-binding protein|collagen prolyl 4-hydroxylase beta|glutathione-insulin transhydrogenase|p55|procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide|prolyl 4-hydroxylase subunit beta|protein disulfide isomerase family A, member 1|protein disulfide isomerase-associated 1|protein disulfide isomerase/oxidoreductase|protein disulfide-isomerase|protocollagen hydroxylase|thyroid hormone-binding protein p55
Super-classes obo:OGG_2060009606c

PCCAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005095
Description

Other designations: PCCase alpha subunit|pccA complementation group|propanoyl-CoA:carbon dioxide ligase alpha subunit|propionyl Coenzyme A carboxylase, alpha polypeptide|propionyl-CoA carboxylase alpha chain, mitochondrial
Super-classes obo:OGG_2060009606c

PCDH9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005101
Description

Other designations: cadherin superfamily protein VR4-11|protocadherin-9
Super-classes obo:OGG_2060009606c

PCK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005105
Description

Other designations: PEP carboxykinase|phosphoenolpyruvate carboxykinase, cytosolic|phosphoenolpyruvate carboxykinase, cytosolic [GTP]|phosphoenolpyruvate carboxylase|phosphopyruvate carboxylase
Super-classes obo:OGG_2060009606c

PCK2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005106
Description

Other designations: PEP carboxykinase|phosphoenolpyruvate carboxykinase [GTP], mitochondrial|phosphoenolpyruvate carboxylase|phosphopyruvate carboxylase
Super-classes obo:OGG_2060009606c

PDE2Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005138
Description

Other designations: cGMP-dependent 3',5'-cyclic phosphodiesterase|cGMP-stimulated phosphodiesterase 1|cGMP-stimulated phosphodiesterase 4|cyclic GMP-stimulated phosphodiesterase
Super-classes obo:OGG_2060009606c

PDK4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005166
Description

Other designations: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial|[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 4|pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
Super-classes obo:OGG_2060009606c

PGRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005241
Description

Other designations: nuclear receptor subfamily 3 group C member 3
Super-classes obo:OGG_2060009606c

PIK3C2Gc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005288
Description

Other designations: PTDINS-3-kinase C2 gamma|phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma|phosphoinositide-3-kinase, class 2, gamma polypeptide|ptdIns-3-kinase C2 subunit gamma
Super-classes obo:OGG_2060009606c

PIK3CAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005290
Description

Other designations: PI3-kinase p110 subunit alpha|PI3K-alpha|phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha|phosphatidylinositol 3-kinase, catalytic, alpha polypeptide|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform|phosphoinositide-3-kinase, catalytic, alpha polypeptide|ptdIns-3-kinase subunit p110-alpha|serine/threonine protein kinase PIK3CA
Super-classes obo:OGG_2060009606c

PITX2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005308
Description

Other designations: ALL1-responsive protein ARP1|all1-responsive gene 1|homeobox protein PITX2|paired-like homeodomain transcription factor 2|pituitary homeobox 2|rieg bicoid-related homeobox transcription factor 1|solurshin
Super-classes obo:OGG_2060009606c

PLA2G1Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005319
Description

Other designations: phosphatidylcholine 2-acylhydrolase 1B|phospholipase A2
Super-classes obo:OGG_2060009606c

PLA2G5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005322
Description

Other designations: Ca2+-dependent phospholipase A2|calcium-dependent phospholipase A2|phosphatidylcholine 2-acylhydrolase 5
Super-classes obo:OGG_2060009606c

PLNc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005350
Description

Other designations: cardiac phospholamban
Super-classes obo:OGG_2060009606c

PMAIP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005366
Description

Other designations: PMA-induced protein 1|adult T cell leukemia-derived PMA-responsive|immediate-early-response protein APR|protein Noxa
Super-classes obo:OGG_2060009606c

PMM1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005372
Description

Other designations: PMM 1|PMMH-22|brain glucose-1,6-bisphosphatase
Super-classes obo:OGG_2060009606c

PORc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005447
Description

Other designations: NADPH--cytochrome P450 reductase|NADPH-dependent cytochrome P450 reductase
Super-classes obo:OGG_2060009606c

POU6F1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005463
Description

Other designations: POU domain, class 6, transcription factor 1|brain-5|brain-specific homeobox/POU domain protein 5|brn-5|mPOU homeobox protein
Super-classes obo:OGG_2060009606c

PPARAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005465
Description

Other designations: PPAR-alpha|nuclear receptor subfamily 1 group C member 1|peroxisome proliferative activated receptor, alpha|peroxisome proliferator-activated nuclear receptor alpha variant 3
Super-classes obo:OGG_2060009606c

PRKAA1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005562
Description

Other designations: 5'-AMP-activated protein kinase catalytic subunit alpha-1|5'-AMP-activated protein kinase, catalytic alpha-1 chain|ACACA kinase|AMP -activate kinase alpha 1 subunit|AMP-activated protein kinase, catalytic, alpha-1|AMPK alpha 1|AMPK subunit alpha-1|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase|tau-protein kinase PRKAA1
Super-classes obo:OGG_2060009606c

PKIBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005570
Description

Other designations: PKI-beta|cAMP-dependent protein kinase inhibitor 2|cAMP-dependent protein kinase inhibitor beta
Super-classes obo:OGG_2060009606c

PRKCBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005579
Description

Other designations: PKC-B|protein kinase C beta type|protein kinase C, beta 1 polypeptide
Super-classes obo:OGG_2060009606c

MAPK8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005599
Description

Other designations: JUN N-terminal kinase|MAP kinase 8|c-Jun N-terminal kinase 1|mitogen-activated protein kinase 8 isoform JNK1 alpha1|mitogen-activated protein kinase 8 isoform JNK1 beta2|stress-activated protein kinase 1|stress-activated protein kinase 1c
Super-classes obo:OGG_2060009606c

MAP2K6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005608
Description

Other designations: MAPK/ERK kinase 6|MAPKK 6|MEK 6|SAPK kinase 3|dual specificity mitogen-activated protein kinase kinase 6|protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)|stress-activated protein kinase kinase 3
Super-classes obo:OGG_2060009606c

EIF2AK2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005610
Description

Other designations: P1/eIF-2A protein kinase|double stranded RNA activated protein kinase|eIF-2A protein kinase 2|interferon-induced, double-stranded RNA-activated protein kinase|interferon-inducible elF2alpha kinase|p68 kinase|protein kinase, interferon-inducible double stranded RNA dependent|tyrosine-protein kinase EIF2AK2
Super-classes obo:OGG_2060009606c

DNAJC3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005611
Description

Other designations: ER-resident protein ERdj6|dnaJ homolog subfamily C member 3|endoplasmic reticulum DNA J domain-containing protein 6|endoplasmic reticulum DnaJ protein 6|interferon-induced, double-stranded RNA-activated protein kinase inhibitor|protein kinase inhibitor of 58 kDa|protein kinase inhibitor p58|protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
Super-classes obo:OGG_2060009606c

PTGER4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005734
Description

Other designations: PGE receptor EP4 subtype|PGE receptor, EP4 subtype|PGE2 receptor EP4 subtype|prostaglandin E2 receptor EP4 subtype|prostanoid EP4 receptor
Super-classes obo:OGG_2060009606c

PTPN4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005775
Description

Other designations: PTPase-MEG1|megakaryocyte phosphatase|megakaryocyte protein-tyrosine phosphatase|protein tyrosine phosphatase MEG1|protein-tyrosine phosphatase MEG1|tyrosine-protein phosphatase non-receptor type 4
Super-classes obo:OGG_2060009606c

PTPN6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005777
Description

Other designations: hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6
Super-classes obo:OGG_2060009606c

PVT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005820
Description

olfactory receptor family 3 subfamily A member 4 pseudogene
Super-classes obo:OGG_2100009606c
Sub-classes obo:TXPO_0004792c

PEX19c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005824
Description

Other designations: 33 kDa housekeeping protein|housekeeping gene, 33kD|peroxin-19|peroxisomal farnesylated protein
Super-classes obo:OGG_2060009606c

RAB13c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005872
Description

Other designations: RAS-associated protein RAB13|cell growth-inhibiting gene 4 protein|growth-inhibiting gene 4 protein|ras-related protein Rab-13
Super-classes obo:OGG_2060009606c

RAD51Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005890
Description

Other designations: DNA repair protein RAD51 homolog 2|RAD51 homolog B|RecA-like protein|recombination repair protein
Super-classes obo:OGG_2060009606c

RBL1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005933
Description

Other designations: 107 kDa retinoblastoma-associated protein|cellular protein 107|retinoblastoma-like 1 (p107)|retinoblastoma-like protein 1
Super-classes obo:OGG_2060009606c

RFX3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000005991
Description

Other designations: DNA binding protein RFX3|transcription factor RFX3
Super-classes obo:OGG_2060009606c

RNF2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006045
Description

Other designations: E3 ubiquitin-protein ligase RING2|HIP2-interacting protein 3|RING finger protein 1B|RING finger protein BAP-1|huntingtin-interacting protein 2-interacting protein 3|protein DinG
Super-classes obo:OGG_2060009606c

BRD2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006046
Description

Other designations: O27.1.1|bromodomain-containing 2|bromodomain-containing protein 2|female sterile homeotic-related gene 1|really interesting new gene 3 protein
Super-classes obo:OGG_2060009606c

ROCK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006093
Description

Other designations: Rho kinase|p160 ROCK-1|p160-ROCK|renal carcinoma antigen NY-REN-35|rho-associated protein kinase 1|rho-associated, coiled-coil-containing protein kinase 1|rho-associated, coiled-coil-containing protein kinase I
Super-classes obo:OGG_2060009606c

RPS29c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006235
Description

Other designations: 40S ribosomal protein S29
Super-classes obo:OGG_2060009606c

SCDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006319
Description

Other designations: acyl-CoA desaturase|delta(9)-desaturase|delta-9 desaturase|delta-9-desaturase|fatty acid desaturase|predicted protein of HQ0998|stearoyl-CoA desaturase opposite strand
Super-classes obo:OGG_2060009606c

SCO1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006341
Description

Other designations: SCO cytochrome oxidase deficient homolog 1|protein SCO1 homolog, mitochondrial
Super-classes obo:OGG_2060009606c

CCL2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006347
Description

Other designations: C-C motif chemokine 2|monocyte chemoattractant protein 1|monocyte chemoattractant protein-1|monocyte chemotactic and activating factor|monocyte chemotactic protein 1|monocyte secretory protein JE|small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)|small inducible cytokine subfamily A (Cys-Cys), member 2|small-inducible cytokine A2
Super-classes obo:OGG_2060009606c

CXCL6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006372
Description

Other designations: C-X-C motif chemokine 6|Small inducible cytokine subfamily B (Cys-X-Cys), member b|chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)|chemokine alpha 3|granulocyte chemotactic protein 2|small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2)|small-inducible cytokine B6
Super-classes obo:OGG_2060009606c

SEL1Lc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006400
Description

Other designations: Suppressor of lin 12 (sel-1), C. elegans, homolog of|protein sel-1 homolog 1|sel-1 suppressor of lin-12-like 1|suppressor of lin-12-like protein 1
Super-classes obo:OGG_2060009606c

SRSF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006426
Description

Other designations: ASF-1|SR splicing factor 1|alternative-splicing factor 1|pre-mRNA-splicing factor SF2, P33 subunit|splicing factor 2|splicing factor, arginine/serine-rich 1
Super-classes obo:OGG_2060009606c

SLC1A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006506
Description

Other designations: excitatory amino acid transporter 2|excitotoxic amino acid transporter 2|glutamate/aspartate transporter II|sodium-dependent glutamate/aspartate transporter 2
Super-classes obo:OGG_2060009606c

SLC2A3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006515
Description

Other designations: GLUT-3|glucose transporter type 3, brain|solute carrier family 2, facilitated glucose transporter member 3
Super-classes obo:OGG_2060009606c

SLC3A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006519
Description

Other designations: B(0,+)-type amino acid transport protein|SLC3A1 variant B|SLC3A1 variant C|SLC3A1 variant D|SLC3A1 variant E|SLC3A1 variant F|SLC3A1 variant G|amino acid transporter 1|neutral and basic amino acid transport protein rBAT|solute carrier family 3 (cystine, dibasic and neutral amino acid transporters), member 1|solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1|solute carrier family 3 member 1
Super-classes obo:OGG_2060009606c

SLC10A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006554
Description

Other designations: Na(+)/bile acid cotransporter|Na(+)/taurocholate transport protein|Na/taurocholate cotransporting polypeptide|cell growth-inhibiting gene 29 protein|growth-inhibiting protein 29|sodium/bile acid cotransporter|sodium/taurocholate cotransporter|sodium/taurocholate cotransporting polypeptide|solute carrier family 10 (sodium/bile acid cotransporter family), member 1|solute carrier family 10 member 1
Super-classes obo:OGG_2060009606c

SMN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006606
Description

Other designations: component of gems 1|gemin-1|survival motor neuron 1 protein|survival motor neuron protein|tudor domain containing 16A
Super-classes obo:OGG_2060009606c

SMOc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006608
Description

Other designations: frizzled family member 11|protein Gx|seven transmembrane helix receptor|smoothened homolog|smoothened, frizzled family receptor|smoothened, seven transmembrane spanning receptor
Super-classes obo:OGG_2060009606c

SMPD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006609
Description

Other designations: acid sphingomyelinase|sphingomyelin phosphodiesterase
Super-classes obo:OGG_2060009606c

SREBF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006720
Description

Other designations: SREBP-1|class D basic helix-loop-helix protein 1|sterol regulatory element-binding protein 1
Super-classes obo:OGG_2060009606c

SRPK2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006733
Description

Other designations: SFRS protein kinase 2|SR protein kinase 2|SR-protein-specific kinase 2|serine kinase SRPK2|serine/arginine-rich protein-specific kinase 2|serine/arginine-rich splicing factor kinase 2|serine/threonine-protein kinase SRPK2
Super-classes obo:OGG_2060009606c

SSBP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006742
Description

Other designations: PWP1-interacting protein 17|single-stranded DNA-binding protein, mitochondrial
Super-classes obo:OGG_2060009606c

SSR3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006747
Description

Other designations: SSR gamma|SSR-gamma|TRAP-complex gamma subunit|TRAP-gamma|signal sequence receptor subunit gamma|translocon-associated protein gamma subunit|translocon-associated protein subunit gamma
Super-classes obo:OGG_2060009606c

STAT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006772
Description

Other designations: signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
Super-classes obo:OGG_2060009606c

STAT3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006774
Description

Other designations: DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3
Super-classes obo:OGG_2060009606c

HSPA13c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006782
Description

Other designations: heat shock 70 kDa protein 13|microsomal stress 70 protein ATPase core|microsomal stress-70 protein ATPase core|stress 70 protein chaperone, microsome-associated, 60kD|stress 70 protein chaperone, microsome-associated, 60kDa|stress-70 protein chaperone microsome-associated 60 kDa protein
Super-classes obo:OGG_2060009606c

STK11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006794
Description

Other designations: liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11
Super-classes obo:OGG_2060009606c

SULT1C2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006819
Description

Other designations: SULT1C#1|sulfotransferase 1C1|sulfotransferase 1C2|sulfotransferase family, cytosolic, 1C, member 1
Super-classes obo:OGG_2060009606c

TAGLNc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006876
Description

Other designations: 22 kDa actin-binding protein|SM22-alpha|smooth muscle protein 22-alpha|transgelin variant 2
Super-classes obo:OGG_2060009606c

TAF9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000006880
Description

Other designations: RNA polymerase II TBP-associated factor subunit G|transcription initiation factor TFIID 31 kD subunit|transcription initiation factor TFIID 31 kDa subunit|transcription initiation factor TFIID 32 kDa subunit|transcription initiation factor TFIID subunit 9
Super-classes obo:OGG_2060009606c

THBS1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007057
Description

Other designations: thrombospondin-1|thrombospondin-1p180
Super-classes obo:OGG_2060009606c

TIMP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007076
Description

Other designations: TIMP-1|collagenase inhibitor|erythroid potentiating activity|erythroid-potentiating activity|fibroblast collagenase inhibitor|metalloproteinase inhibitor 1|tissue inhibitor of metalloproteinases 1
Super-classes obo:OGG_2060009606c

TLR4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007099
Description

Other designations: hToll|homolog of Drosophila toll
Super-classes obo:OGG_2060009606c

TMPOc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007112
Description

Other designations: LEM domain containing 4|TP alpha|TP beta/gamma|lamina-associated polypeptide 2|thymopoietin-related peptide isoform alpha|thymopoietin-related peptide isoforms beta/gamma
Super-classes obo:OGG_2060009606c

TNFc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007124
Description

Other designations: APC1 protein|TNF, macrophage-derived|TNF, monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha
Super-classes obo:OGG_2060009606c

TP53c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007157
Description

Other designations: antigen NY-CO-13|cellular tumor antigen p53|mutant tumor protein 53|p53 tumor suppressor|phosphoprotein p53|transformation-related protein 53|tumor protein 53
Super-classes obo:OGG_2060009606c

HSP90B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007184
Description

Other designations: 94 kDa glucose-regulated protein|endoplasmin|endothelial cell (HBMEC) glycoprotein|epididymis luminal protein 35|epididymis secretory sperm binding protein Li 125m|heat shock protein 90 kDa beta member 1|stress-inducible tumor rejection antigen gp96|tumor rejection antigen (gp96) 1|tumor rejection antigen 1
Super-classes obo:OGG_2060009606c

TRAF2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007186
Description

Other designations: E3 ubiquitin-protein ligase TRAF2|tumor necrosis factor type 2 receptor associated protein 3|tumor necrosis factor type 2 receptor-associated protein 3
Super-classes obo:OGG_2060009606c

TRAF3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007187
Description

Other designations: CD40 associated protein 1|CD40 binding protein|CD40 receptor associated factor 1|LMP1-associated protein 1
Super-classes obo:OGG_2060009606c

DNAJC7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007266
Description

Other designations: TPR repeat protein 2|dnaJ homolog subfamily C member 7|tetratricopeptide repeat domain 2|tetratricopeptide repeat protein 2
Super-classes obo:OGG_2060009606c

TWIST1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007291
Description

Other designations: B-HLH DNA binding protein|H-twist|TWIST homolog of drosophila|class A basic helix-loop-helix protein 38|craniosynostosis|twist basic helix-loop-helix transcription factor 1|twist homolog 1|twist-related protein 1
Super-classes obo:OGG_2060009606c

TXNRD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007296
Description

Other designations: KM-102-derived reductase-like factor|gene associated with retinoic and IFN-induced mortality 12 protein|gene associated with retinoic and interferon-induced mortality 12 protein|oxidoreductase|thioredoxin reductase 1, cytoplasmic|thioredoxin reductase GRIM-12|thioredoxin reductase TR1
Super-classes obo:OGG_2060009606c

TYMSc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007298
Description

Other designations: TSase|thymidylate synthase
Super-classes obo:OGG_2060009606c

UBE2Ic # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007329
Description

Other designations: SUMO-1-protein ligase|SUMO-conjugating enzyme UBC9|SUMO-protein ligase|ubiquitin carrier protein 9|ubiquitin carrier protein I|ubiquitin conjugating enzyme 9|ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)|ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)|ubiquitin-conjugating enzyme UbcE2A|ubiquitin-like protein SUMO-1 conjugating enzyme|ubiquitin-protein ligase E2I|ubiquitin-protein ligase I
Super-classes obo:OGG_2060009606c

UCP3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007352
Description

Other designations: mitochondrial uncoupling protein 3|solute carrier family 25 member 9
Super-classes obo:OGG_2060009606c

UGCGc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007357
Description

Other designations: GLCT-1|UDP-glucose:N-acylsphingosine D-glucosyltransferase|ceramide glucosyltransferase|glucosylceramide synthase
Super-classes obo:OGG_2060009606c

UGT2B7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007364
Description

Other designations: 3,4-catechol estrogen specific|3,4-catechol estrogen-specific UDPGT|UDP glucuronosyltransferase 2B7|UDP-glucuronosyltransferase 2B7|UDP-glucuronosyltransferase 2B9|UDP-glucuronyltransferase, family 2, beta-7|UDPGT 2B7|UDPGTh-2
Super-classes obo:OGG_2060009606c

NR1H2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007376
Description

Other designations: LX receptor beta|liver X nuclear receptor beta|nuclear orphan receptor LXR-beta|nuclear receptor NER|oxysterols receptor LXR-beta|steroid hormone-nuclear receptor NER|ubiquitously-expressed nuclear receptor
Super-classes obo:OGG_2060009606c

USF2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007392
Description

Other designations: FOS-interacting protein|c-fos interacting protein|class B basic helix-loop-helix protein 12|major late transcription factor 2|upstream stimulatory factor 2
Super-classes obo:OGG_2060009606c

VAV2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007410
Description

Other designations: guanine nucleotide exchange factor VAV2|vav 2 oncogene
Super-classes obo:OGG_2060009606c

EIF4Hc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007458
Description

Other designations: Williams-Beuren syndrome chromosome region 1
Super-classes obo:OGG_2060009606c

XBP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007494
Description

Other designations: X-box-binding protein 1|tax-responsive element-binding protein 5
Super-classes obo:OGG_2060009606c

LRP8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007804
Description

Other designations: ApoE receptor 2|low-density lipoprotein receptor-related protein 8
Super-classes obo:OGG_2060009606c

BTG2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007832
Description

Other designations: B-cell translocation gene 2|NGF-inducible anti-proliferative protein PC3|nerve growth factor-inducible anti-proliferative|pheochromacytoma cell-3|protein BTG2
Super-classes obo:OGG_2060009606c

MANFc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007873
Description

Other designations: arginine-rich, mutated in early stage tumors
Super-classes obo:OGG_2060009606c

AIMP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000007965
Description

Other designations: ARS-interacting multi-functional protein 2|aminoacyl tRNA synthase complex-interacting multifunctional protein 2|multisynthase complex auxiliary component p38|multisynthetase complex auxiliary component p38|protein JTV-1
Super-classes obo:OGG_2060009606c

ACOX2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008309
Description

Other designations: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase|THCA-CoA oxidase|acyl-Coenzyme A oxidase 2, branched chain|peroxisomal acyl-coenzyme A oxidase 2|peroxisomal branched chain acyl-CoA oxidase|trihydroxycoprostanoyl-CoA oxidase
Super-classes obo:OGG_2060009606c

ACOX3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008310
Description

Other designations: BRCACox|acyl-Coenzyme A oxidase 3, pristanoyl|branched-chain acyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 3|pristanoyl-CoA oxidase
Super-classes obo:OGG_2060009606c

HIST2H2AA3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008337
Description

Other designations: H2A histone family, member O|histone 2, H2aa3|histone H2A type 2-A
Super-classes obo:OGG_2060009606c

HIST1H2BGc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008339
Description

Other designations: H2B histone family, member A|histone 1, H2bg|histone H2B type 1-C/E/F/G/I|histone H2B.1 A|histone H2B.a
Super-classes obo:OGG_2060009606c

NR0B2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008431
Super-classes obo:CHEBI_25367c
obo:OGG_2060009606c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008431c
Sub-classes obo:TXPO_0003333c

IKBKGc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008517
Description

Other designations: I-kappa-B kinase subunit gamma|IKKAP1|IKKG|IkB kinase gamma subunit|NF-kappa-B essential modifier|NF-kappa-B essential modulator|NFkappaB essential modulator|ikB kinase subunit gamma|ikB kinase-associated protein 1|incontinentia pigmenti|inhibitor of nuclear factor kappa-B kinase subunit gamma
Super-classes obo:OGG_2060009606c

CYP4F2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008529
Description

Other designations: CYPIVF2|cytochrome P450 4F2|cytochrome P450, subfamily IVF, polypeptide 2|cytochrome P450-LTB-omega|leukotriene B4 omega-hydroxylase|leukotriene-B(4) 20-monooxygenase 1|leukotriene-B(4) omega-hydroxylase 1|leukotriene-B4 20-monooxygenase
Super-classes obo:OGG_2060009606c

PIRc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008544
Description

Other designations: pirin|probable quercetin 2,3-dioxygenase PIR|probable quercetinase
Super-classes obo:OGG_2060009606c

PRKRAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008575
Description

Other designations: PKR-associated protein X|PKR-associating protein X|interferon-inducible double stranded RNA-dependent protein kinase activator A|interferon-inducible double-stranded RNA-dependent protein kinase activator A|protein activator of the interferon-induced protein kinase|protein kinase, interferon-inducible double stranded RNA-dependent activator|protein kinase, interferon-inducible double-stranded RNA-dependent activator
Super-classes obo:OGG_2060009606c

EIF4EBP3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008637
Description

Other designations: eIF4E-binding protein 3|eukaryotic initiation factor 4E-binding protein 3|eukaryotic translation initiation factor 4E-binding protein 3
Super-classes obo:OGG_2060009606c

ABCB11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008647
Description

Other designations: ABC member 16, MDR/TAP subfamily|ATP-binding cassette sub-family B member 11|bile salt export pump|progressive familial intrahepatic cholestasis 2|sister p-glycoprotein
Super-classes obo:OGG_2060009606c

EIF3Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008661
Description

Other designations: EIF3, p180 subunit|centrosomin homolog|cytoplasmic protein p167|eIF-3-theta|eIF3 p167|eIF3 p180|eIF3 p185|eukaryotic translation initiation factor 3 subunit 10|eukaryotic translation initiation factor 3 subunit A|eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)|eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)|eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa|eukaryotic translation initiation factor 3, subunit 10, 170kD
Super-classes obo:OGG_2060009606c

EIF3Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008662
Description

Other designations: eIF-3-eta|eIF3 p110|eIF3 p116|eukaryotic translation initiation factor 3 subunit 9|eukaryotic translation initiation factor 3 subunit B|eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)|eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa|hPrt1|prt1 homolog
Super-classes obo:OGG_2060009606c

EIF3Cc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008663
Description

Other designations: cell migration-inducing protein 17|eIF3 p110|eukaryotic translation initiation factor 3 subunit 8|eukaryotic translation initiation factor 3 subunit C|eukaryotic translation initiation factor 3, subunit 8 (110kD)|eukaryotic translation initiation factor 3, subunit 8, 110kDa
Super-classes obo:OGG_2060009606c

EIF3Dc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008664
Description

Other designations: eIF-3-zeta|eIF3 p66|eukaryotic translation initiation factor 3 subunit 7|eukaryotic translation initiation factor 3 subunit D|eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa|translation initiation factor eIF3 p66 subunit
Super-classes obo:OGG_2060009606c

EIF3Fc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008665
Description

Other designations: deubiquitinating enzyme eIF3f|eIF-3-epsilon|eIF3-epsilon|eukaryotic translation initiation factor 3 subunit F|eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD)|eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa
Super-classes obo:OGG_2060009606c

EIF3Gc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008666
Description

Other designations: eIF-3 RNA-binding subunit|eIF-3-delta|eIF3 p42|eIF3 p44|eukaryotic translation initiation factor 3 RNA-binding subunit|eukaryotic translation initiation factor 3 subunit 4|eukaryotic translation initiation factor 3 subunit G|eukaryotic translation initiation factor 3 subunit p42|eukaryotic translation initiation factor 3, subunit 4 (delta, 44kD)|eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
Super-classes obo:OGG_2060009606c

EIF3Hc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008667
Description

Other designations: eIF-3-gamma|eIF3 p40 subunit|eukaryotic translation initiation factor 3 subunit 3|eukaryotic translation initiation factor 3 subunit H|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)|eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
Super-classes obo:OGG_2060009606c

EIF3Ic # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008668
Description

Other designations: TGF-beta receptor-interacting protein 1|TGFbeta receptor-interacting protein 1|eIF-3-beta|eIF3 p36|eukaryotic translation initiation factor 3 subunit 2|eukaryotic translation initiation factor 3 subunit I|eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)|eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa|predicted protein of HQ2242
Super-classes obo:OGG_2060009606c

EIF3Jc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008669
Description

Other designations: eukaryotic translation initiation factor 3 subunit J|eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD)
Super-classes obo:OGG_2060009606c

EIF4G3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008672
Description

Other designations: eIF-4-gamma 3|eIF-4-gamma II|eukaryotic translation initiation factor 4 gamma 3
Super-classes obo:OGG_2060009606c

TRADDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008717
Description

Other designations: TNFR1-associated death domain protein|tumor necrosis factor receptor type 1 associated death domain protein|tumor necrosis factor receptor type 1-associated DEATH domain protein|tumor necrosis factor receptor-1-associated protein
Super-classes obo:OGG_2060009606c

TNFSF10c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008743
Description

Other designations: Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|chemokine tumor necrosis factor ligand superfamily member 10|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta|tumor necrosis factor ligand superfamily member 10
Super-classes obo:OGG_2060009606c

PEX11Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008800
Description

Other designations: 28 kDa peroxisomal integral membrane protein|peroxin-11A|peroxisomal biogenesis factor 11A|peroxisomal membrane protein 11A|protein PEX11 homolog alpha
Super-classes obo:OGG_2060009606c

FGF18c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008817
Description

fibroblast growth factor 18
Super-classes obo:OGG_2060009606c

CFLARc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008837
Description

Other designations: FADD-like anti-apoptotic molecule|FADD-like antiapoptotic molecule 1|MACH-related inducer of toxicity|caspase homolog|caspase-eight-related protein|caspase-like apoptosis regulatory protein|caspase-related inducer of apoptosis|cellular FLICE-like inhibitory protein|inhibitor of FLICE|usurpin beta
Super-classes obo:OGG_2060009606c

CDK5R1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008851
Description

Other designations: CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit
Super-classes obo:OGG_2060009606c

NR1I2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008856
Super-classes obo:OGG_2060009606c
Sub-classes obo:TXPO_0002726c

IER3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008870
Description

Other designations: PACAP-responsive gene 1 protein|anti-death protein|differentiation-dependent gene 2 protein|expressed in pancreatic carcinoma|gly96, mouse, homolog of|immediate early protein GLY96|immediate early response 3 protein|immediately early gene X-1|protein DIF-2|radiation-inducible immediate-early gene IEX-1
Super-classes obo:OGG_2060009606c

VNN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008876
Description

Other designations: pantetheinase|pantetheine hydrolase|vanin-1|vannin 1|vascular non-inflammatory molecule 1
Super-classes obo:OGG_2060009606c

SGPL1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008879
Description

Other designations: SP-lyase 1|SPL 1|hSPL|sphingosine-1-phosphate aldolase
Super-classes obo:OGG_2060009606c

SLC5A6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008884
Description

Other designations: Na(+)-dependent multivitamin transporter|Na+-dependent multivitamin transporter|sodium-dependent multivitamin transporter|solute carrier family 5 (sodium-dependent vitamin transporter), member 6|solute carrier family 5 member 6
Super-classes obo:OGG_2060009606c

EIF2B4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008890
Description

Other designations: eIF-2B GDP-GTP exchange factor subunit delta|eukaryotic translation initiation factor 2B subunit 4 delta|translation initiation factor eIF-2B subunit delta|translation initiation factor eIF-2b delta subunit
Super-classes obo:OGG_2060009606c

EIF2B3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008891
Description

Other designations: eIF-2B GDP-GTP exchange factor subunit gamma|translation initiation factor eIF-2B subunit gamma
Super-classes obo:OGG_2060009606c

EIF2B2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008892
Description

Other designations: S20I15|S20III15|eIF-2B GDP-GTP exchange factor subunit beta|translation initiation factor eIF-2B subunit beta
Super-classes obo:OGG_2060009606c

EIF2B5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008893
Description

Other designations: eIF-2B GDP-GTP exchange factor subunit epsilon|translation initiation factor eIF-2B subunit epsilon
Super-classes obo:OGG_2060009606c

EIF2S2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008894
Description

Other designations: eukaryotic translation initiation factor 2 subunit 2|eukaryotic translation initiation factor 2 subunit beta|protein phosphatase 1, regulatory subunit 67
Super-classes obo:OGG_2060009606c

SKAP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000008935
Description

Other designations: Fyn-associated phosphoprotein SKAP55 homologue|Pyk2/RAFTK-associated protein|SKAP-55HOM|SKAP55 homolog|retinoic acid-induced protein 70|src family associated phosphoprotein 2|src family-associated phosphoprotein 2|src kinase-associated phosphoprotein 2|src kinase-associated phosphoprotein 55-related protein|src kinase-associated phosphoprotein of 55-related protein|src-associated adapter protein with PH and SH3 domains|src-associated adaptor protein
Super-classes obo:OGG_2060009606c

ANGPTL1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009068
Description

Other designations: ANG-3|angioarrestin|angiopoietin 3|angiopoietin Y1|angiopoietin-3|angiopoietin-like protein 1|angiopoietin-related protein 1|dJ595C2.2 (angiopoietin Y1)
Super-classes obo:OGG_2060009606c

EIF1AYc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009086
Description

Other designations: eIF-1A Y isoform|eukaryotic translation initiation factor 1A, Y chromosome|eukaryotic translation initiation factor 1A, Y-chromosomal|eukaryotic translation initiation factor 4C
Super-classes obo:OGG_2060009606c

CCNB2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009133
Description

Other designations: G2/mitotic-specific cyclin-B2
Super-classes obo:OGG_2060009606c

SYNGR2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009144
Description

Other designations: cellugyrin|synaptogyrin-2
Super-classes obo:OGG_2060009606c

PCSK7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009159
Description

Other designations: lymphoma proprotein convertase|prohormone convertase 7|prohormone convertase PC7|proprotein convertase 7|proprotein convertase 8|proprotein convertase PC7|subtilisin/kexin-like protease PC7
Super-classes obo:OGG_2060009606c

MAP3K13c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009175
Description

Other designations: leucine zipper-bearing kinase|mixed lineage kinase
Super-classes obo:OGG_2060009606c

DDX21c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009188
Description

Other designations: DEAD (Asp-Glu-Ala-Asp) box polypeptide 21|DEAD box protein 21|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21|Gu protein|RH II/Gu|RNA helicase II/Gu alpha|gu-alpha|nucleolar RNA helicase 2|nucleolar RNA helicase Gu|nucleolar RNA helicase II
Super-classes obo:OGG_2060009606c

NOLC1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009221
Description

Other designations: 140 kDa nucleolar phosphoprotein|HCV NS5A trans-regulated protein 13|HCV NS5A-transactivated protein 13|hepatitis C virus NS5A-transactivated protein 13|nucleolar 130 kDa protein|nucleolar and coiled-body phosphprotein 1|nucleolar phosphoprotein p130|nucleolar protein p130
Super-classes obo:OGG_2060009606c

RECQL5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009400
Description

Other designations: ATP-dependent DNA helicase Q5|DNA helicase, RecQ-like type 5
Super-classes obo:OGG_2060009606c

FADS2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009415
Description

Other designations: delta(6) desaturase|delta(6) fatty acid desaturase|delta-6 desaturase|delta-6 fatty acid desaturase|delta-6-desaturase|linoleoyl-CoA desaturase (delta-6-desaturase)-like 2
Super-classes obo:OGG_2060009606c

CYP7B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009420
Description

Other designations: 25-hydroxycholesterol 7-alpha-hydroxylase|cytochrome P450 7B1|cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1|oxysterol 7-alpha-hydroxylase|oxysterol 7alpha-hydroxylase
Super-classes obo:OGG_2060009606c

MED23c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009439
Description

Other designations: 130 kDa transcriptional co-activator|133 kDa transcriptional co-activator|activator-recruited cofactor 130 kDa component|cofactor required for Sp1 transcriptional activation subunit 3|mediator of RNA polymerase II transcription subunit 23|vitamin D3 receptor interacting protein
Super-classes obo:OGG_2060009606c

EIF2AK3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009451
Description

Other designations: PRKR-like endoplasmic reticulum kinase|eukaryotic translation initiation factor 2 alpha kinase 3|hsPEK|pancreatic EIF2-alpha kinase
Super-classes obo:OGG_2060009606c

EIF4E2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009470
Description

Other designations: eIF-4E type 2|eIF4E-like cap-binding protein|eIF4E-like protein 4E-LP|eukaryotic translation initiation factor 4E homologous protein|eukaryotic translation initiation factor 4E type 2|eukaryotic translation initiation factor 4E-like 3|mRNA cap-binding protein type 3
Super-classes obo:OGG_2060009606c

SPTLC2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009517
Description

Other designations: LCB 2|SPT 2|long chain base biosynthesis protein 2a|serine palmitoyltransferase 2|serine palmitoyltransferase, subunit II|serine-palmitoyl-CoA transferase 2
Super-classes obo:OGG_2060009606c

GDF15c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009518
Description

Other designations: NRG-1|NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1|NSAID-activated gene 1 protein|NSAID-regulated gene 1 protein|PTGF-beta|growth/differentiation factor 15|macrophage inhibitory cytokine 1|placental TGF-beta|placental bone morphogenetic protein|prostate differentiation factor
Super-classes obo:OGG_2060009606c

IKBKEc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009641
Description

Other designations: I-kappa-B kinase epsilon|IKK-epsilon|IKK-related kinase epsilon|inducible I kappa-B kinase|inducible IkappaB kinase|inhibitor of nuclear factor kappa-B kinase subunit epsilon
Super-classes obo:OGG_2060009606c

GCC2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009648
Description

Other designations: 185 kDa Golgi coiled-coil protein|CLL-associated antigen KW-11|CTCL tumor antigen se1-1|GCC protein, 185-kD|GRIP and coiled-coil domain-containing protein 2|Golgi coiled-coil protein GCC185|Ran-binding protein 2-like 4|renal carcinoma antigen NY-REN-53
Super-classes obo:OGG_2060009606c

EIF5Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009669
Description

Other designations: eIF-5B|translation initiation factor IF-2|translation initiation factor IF2
Super-classes obo:OGG_2060009606c

EDEM1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009695
Description

Other designations: ER degradation-enhancing alpha-mannosidase-like 1|ER degradation-enhancing alpha-mannosidase-like protein 1
Super-classes obo:OGG_2060009606c

HERPUD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009709
Description

Other designations: MMS-inducible|homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein|homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein|methyl methanesulfonate (MMF)-inducible fragment protein 1
Super-classes obo:OGG_2060009606c

KIAA0101c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009768
Description

Other designations: HCV NS5A-transactivated protein 9|PCNA-associated factor|PCNA-associated factor of 15 kDa|hepatitis C virus NS5A-transactivated protein 9|overexpressed in anaplastic thyroid carcinoma 1
Super-classes obo:OGG_2060009606c

EIF4A3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009775
Description

Other designations: ATP-dependent RNA helicase DDX48|ATP-dependent RNA helicase eIF4A-3|DEAD (Asp-Glu-Ala-Asp) box polypeptide 48|DEAD box protein 48|NMP 265|eIF-4A-III|eIF4A-III|eukaryotic initiation factor 4A-III|eukaryotic initiation factor 4A-like NUK-34|eukaryotic translation initiation factor 4A|hNMP 265|nuclear matrix protein 265
Super-classes obo:OGG_2060009606c

TOMM20c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009804
Description

Other designations: mitochondrial 20 kDa outer membrane protein|mitochondrial import receptor subunit TOM20 homolog|outer mitochondrial membrane receptor Tom20|translocase of outer mitochondrial membrane 20 homolog type II
Super-classes obo:OGG_2060009606c

DNAJC6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009829
Description

Other designations: DnaJ (Hsp40) homolog, subfamily B, member 6|auxilin|putative tyrosine-protein phosphatase auxilin
Super-classes obo:OGG_2060009606c

SEC24Dc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009871
Description

Other designations: SEC24 family, member D|SEC24 related gene family, member D|SEC24-related protein D|protein transport protein Sec24D
Super-classes obo:OGG_2060009606c

NUAK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009891
Description

Other designations: AMP-activated protein kinase family member 5|AMPK-related protein kinase 5|NUAK family SNF1-like kinase 1|omphalocele kinase 1
Super-classes obo:OGG_2060009606c

LPGAT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009926
Description

Other designations: acyl-CoA:lysophosphatidylglycerol acyltransferase 1|family with sequence similarity 34, member A
Super-classes obo:OGG_2060009606c

RBM8Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009939
Description

Other designations: BOV-1|RNA binding motif protein 8B|RNA-binding motif protein 8A|RNA-binding protein 8A|RNA-binding protein Y14|binder of OVCA1-1|ribonucleoprotein RBM8|ribonucleoprotein RBM8A
Super-classes obo:OGG_2060009606c

FGF19c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009965
Description

Other designations: FGF-19
Super-classes obo:OGG_2060009606c

NR1I3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009970
Description

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Super-classes obo:OGG_2060009606c

NR1H4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009971
Description

nuclear receptor subfamily 1, group H, member 4
Super-classes obo:OGG_2060009606c

NUP153c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009972
Description

Other designations: 153 kDa nucleoporin|nuclear pore complex protein Nup153|nuclear pore complex protein hnup153|nucleoporin Nup153
Super-classes obo:OGG_2060009606c

CASP8AP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000009994
Description

Other designations: CASP8 associated protein 2|CASP8-associated protein 2|FLASH homolog RIP25|FLICE associated huge|FLICE-associated huge protein|human FLASH
Super-classes obo:OGG_2060009606c

ACOT8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010005
Description

Other designations: HIV-Nef associated acyl-CoA thioesterase|acyl-coenzyme A thioesterase 8|choloyl-CoA hydrolase|choloyl-coenzyme A thioesterase|long-chain fatty-acyl-CoA hydrolase|palmitoyl-CoA hydrolase|peroxisomal acyl-CoA thioesterase 1|peroxisomal acyl-coenzyme A thioester hydrolase 1|peroxisomal long-chain acyl-CoA thioesterase 1|thioesterase II|thioesterase III
Super-classes obo:OGG_2060009606c

BCL2L11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010018
Description

Other designations: bcl-2 interacting mediator of cell death|bcl-2 interacting protein Bim|bcl-2-like protein 11|bcl-2-related ovarian death agonist
Super-classes obo:OGG_2060009606c

GNEc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010020
Description

Other designations: N-acylmannosamine kinase|UDP-GlcNAc-2-epimerase/ManAc kinase|UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase|UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase|bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Super-classes obo:OGG_2060009606c

DNAJB6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010049
Description

Other designations: DnaJ-like 2 protein|dnaJ homolog subfamily B member 6|heat shock protein J2|limb girdle muscular dystrophy 1D (autosomal dominant)
Super-classes obo:OGG_2060009606c

AP1M2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010053
Description

Other designations: AP-1 complex subunit mu-2|AP-mu chain family member mu1B|HA1 47 kDa subunit 2|adaptor protein complex AP-1 mu-2 subunit|adaptor protein complex AP-1 subunit mu-2|adaptor-related protein complex 1 mu-2 subunit|adaptor-related protein complex 1 subunit mu-2|clathrin assembly protein complex 1 medium chain 2|clathrin assembly protein complex 1 mu-2 medium chain 2|clathrin coat assembly protein AP47 2|clathrin coat associated protein AP47 2|clathrin-associated adaptor medium chain mu2|golgi adaptor AP-1 47 kDa protein|golgi adaptor HA1/AP1 adaptin mu-2 subunit|mu-adaptin 2|mu1B-adaptin
Super-classes obo:OGG_2060009606c

RASGRP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010125
Description

Other designations: RAS guanyl nucleotide-releasing protein 1|RAS guanyl-releasing protein 1|calcium and DAG-regulated guanine nucleotide exchange factor II|guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A|ras activator RasGRP
Super-classes obo:OGG_2060009606c

EIF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010209
Description

Other designations: protein translation factor SUI1 homolog|sui1iso1
Super-classes obo:OGG_2060009606c

ANGPTL7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010218
Description

Other designations: angiopoietin-like factor (CDT6)|angiopoietin-like protein 7|angiopoietin-related protein 7|cornea-derived transcript 6 protein
Super-classes obo:OGG_2060009606c

GPHNc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010243
Description

gephyrin
Super-classes obo:OGG_2060009606c

STUB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010273
Description

Other designations: CLL-associated antigen KW-8|E3 ubiquitin-protein ligase CHIP|STIP1 homology and U box-containing protein 1|antigen NY-CO-7|carboxy terminus of Hsp70-interacting protein|heat shock protein A binding protein 2 (c-terminal)|serologically defined colon cancer antigen 7
Super-classes obo:OGG_2060009606c

EIF1Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010289
Description

Other designations: eukaryotic translation initiation factor 1b|protein translation factor SUI1 homolog GC20|translation factor sui1 homolog
Super-classes obo:OGG_2060009606c

TUBB4Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010382
Description

Other designations: dystonia 4, torsion (autosomal dominant)|tubulin beta-4 chain|tubulin beta-4A chain|tubulin, beta, 5
Super-classes obo:OGG_2060009606c

PIAS3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010401
Description

Other designations: E3 SUMO-protein ligase PIAS3|protein inhibitor of activated STAT protein 3|zinc finger, MIZ-type containing 5
Super-classes obo:OGG_2060009606c

CPQc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010404
Description

Other designations: Ser-Met dipeptidase|aminopeptidase|blood plasma glutamate carboxypeptidase|lysosomal dipeptidase
Super-classes obo:OGG_2060009606c

SPON2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010417
Description

Other designations: differentially expressed in cancerous and non-cancerous lung cells 1|spondin-2
Super-classes obo:OGG_2060009606c

PRMT5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010419
Description

Other designations: 72 kDa ICln-binding protein|HMT1 hnRNP methyltransferase-like 5|SKB1 homolog|histone-arginine N-methyltransferase PRMT5|jak-binding protein 1|protein arginine N-methyltransferase 5|shk1 kinase-binding protein 1 homolog
Super-classes obo:OGG_2060009606c

EIF3Mc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010480
Description

Other designations: B5 receptor|PCI domain containing 1 (herpesvirus entry mediator)|PCI domain-containing protein 1|dendritic cell protein|eukaryotic translation initiation factor 3 subunit M|fetal lung protein B5|transport and golgi organization 7 homolog
Super-classes obo:OGG_2060009606c

HYOU1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010525
Description

Other designations: 150 kDa oxygen-regulated protein|170 kDa glucose-regulated protein|hypoxia up-regulated protein 1|oxygen regulated protein (150kD)
Super-classes obo:OGG_2060009606c

GLRX3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010539
Description

Other designations: PKC-interacting cousin of thioredoxin|PKC-theta-interacting protein|PKCq-interacting protein|glutaredoxin 4|glutaredoxin-3|thioredoxin-like protein 2
Super-classes obo:OGG_2060009606c

LAMTOR5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010542
Description

Other designations: HBV X-interacting protein|HBx-interacting protein|hepatitis B virus x interacting protein|hepatitis B virus x-interacting protein (9.6kD)|late endosomal/lysosomal adaptor and MAPK and MTOR activator 5|ragulator complex protein LAMTOR5
Super-classes obo:OGG_2060009606c

HTATIP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010553
Description

Other designations: 30 kDa HIV-1 TAT-interacting protein|HIV-1 TAT-interactive protein 2|Tat-interacting protein (30kD)|oxidoreductase HTATIP2|short chain dehydrogenase/reductase family 44U, member 1
Super-classes obo:OGG_2060009606c

SORBS1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010580
Description

Other designations: Fas-ligand associated factor 2|SH3 domain protein 5|c-Cbl associated protein|ponsin|sorbin and SH3 domain-containing protein 1
Super-classes obo:OGG_2060009606c

MAB21L2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010586
Description

Other designations: protein mab-21-like 2
Super-classes obo:OGG_2060009606c

PDLIM5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010611
Description

Other designations: PDZ and LIM domain protein 5|enigma homolog|enigma-like LIM domain protein|enigma-like PDZ and LIM domains protein
Super-classes obo:OGG_2060009606c

RAD51AP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010635
Description

Other designations: RAD51-associated protein 1|RAD51-interacting protein
Super-classes obo:OGG_2060009606c

RRAGAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010670
Description

Other designations: adenovirus E3 14.7 kDa-interacting protein 1|adenovirus E3-14.7K interacting protein 1|rag A|ras-related GTP-binding protein A
Super-classes obo:OGG_2060009606c

RBBP9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010741
Description

Other designations: B5T overexpressed gene protein|B5T-overexpressed gene protein|RBBP-10|RBBP-9|putative hydrolase RBBP9|retinoblastoma-binding protein 10|retinoblastoma-binding protein 9|retinoma-binding protein 9
Super-classes obo:OGG_2060009606c

PLK2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010769
Description

Other designations: PLK-2|serine/threonine-protein kinase PLK2|serine/threonine-protein kinase SNK|serum-inducible kinase
Super-classes obo:OGG_2060009606c

CCR9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010803
Description

Other designations: C-C chemokine receptor type 9|G protein-coupled receptor 28
Super-classes obo:OGG_2060009606c

PGRMC1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010857
Description

Other designations: membrane-associated progesterone receptor component 1|progesterone binding protein
Super-classes obo:OGG_2060009606c

CYP46A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010858
Description

Other designations: CH24H|cholesterol 24-hydroxylase|cytochrome P450 46A1|cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Super-classes obo:OGG_2060009606c

SUB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010923
Description

Other designations: activated RNA polymerase II transcription cofactor 4|activated RNA polymerase II transcriptional coactivator p15|positive cofactor 4
Super-classes obo:OGG_2060009606c

SMPDL3Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010924
Description

Other designations: 0610010C24Rik|ASM-like phosphodiesterase 3a|acid sphingomyelinase-like phosphodiesterase 3a
Super-classes obo:OGG_2060009606c

DBF4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010926
Description

Other designations: DBF4 homolog|DBF4 zinc finger A|DBF4-type zinc finger-containing protein 1|activator of S phase kinase|chiffon homolog A|protein DBF4 homolog A|zinc finger, DBF-type containing 1
Super-classes obo:OGG_2060009606c

SEC61Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010952
Description

Other designations: Sec61 complex, beta subunit|protein translocation complex beta|protein transport protein SEC61 beta subunit|protein transport protein Sec61 subunit beta
Super-classes obo:OGG_2060009606c

ACOT2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000010965
Description

Other designations: acyl-coenzyme A thioester hydrolase 2a|acyl-coenzyme A thioesterase 2, mitochondrial|long-chain acyl-CoA thioesterase 2|mitochondrial acyl-CoA thioesterase 1|peroxisomal long-chain acyl-coA thioesterase 2
Super-classes obo:OGG_2060009606c

GLIPR1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011010
Description

Other designations: GLI pathogenesis-related 1 (glioma)|gliPR 1|glioma pathogenesis-related protein 1|protein RTVP-1|related to testis-specific, vespid, and pathogenesis proteins 1|testes-specific vespid and pathogenesis protein 1
Super-classes obo:OGG_2060009606c

KDELR2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011014
Description

Other designations: (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2|ER lumen protein retaining receptor 2|ERD-2-like protein|ERD2-like protein 1|KDEL endoplasmic reticulum protein retention receptor 2|KDEL receptor 2
Super-classes obo:OGG_2060009606c

ATF7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011016
Description

Other designations: cyclic AMP-dependent transcription factor ATF-7|transcription factor ATF-A
Super-classes obo:OGG_2060009606c

DNAJB4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011080
Description

Other designations: DnaJ-like heat shock protein 40|HSP40 homolog|dnaJ homolog subfamily B member 4|heat shock 40 kDa protein 1 homolog|heat shock protein 40 homolog|human liver DnaJ-like protein
Super-classes obo:OGG_2060009606c

FAF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011124
Description

Other designations: FAS-associated factor 1|TNFRSF6-associated factor 1|UBX domain protein 3A|UBX domain-containing protein 12|UBX domain-containing protein 3A
Super-classes obo:OGG_2060009606c

PLA2G16c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011145
Description

Other designations: Ca-independent phospholipase A1/2|H-rev 107 protein homolog|HRAS-like suppressor 1|HRAS-like suppressor 3|adipose-specific PLA2|adipose-specific phospholipase A2|group XVI phospholipase A1/A2|group XVI phospholipase A2|renal carcinoma antigen NY-REN-65
Super-classes obo:OGG_2060009606c

NUDT4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011163
Description

Other designations: DIPP-2|diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2|diphosphoinositol polyphosphate phosphohydrolase 2|diphosphoinositol polyphosphate phosphohydrolase type 2
Super-classes obo:OGG_2060009606c

NUDT5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011164
Description

Other designations: 8-oxo-dGDP phosphatase|ADP-sugar pyrophosphatase
Super-classes obo:OGG_2060009606c

CYP4F8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011283
Description

Other designations: cytochrome P450 4F8|cytochrome P450, subfamily IVF, polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase
Super-classes obo:OGG_2060009606c

ACOT7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011332
Description

Other designations: CTE-IIa|acyl-CoA thioesterase 2|acyl-CoA thioesterase, long chain|brain acyl CoA hydrolase|brain acyl-CoA hydrolase|cytosolic acyl coenzyme A thioester hydrolase|long chain acyl-CoA thioester hydrolase
Super-classes obo:OGG_2060009606c

MGLLc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000011343
Description

Other designations: lysophospholipase homolog|monoacylglycerol lipase
Super-classes obo:OGG_2060009606c

ATF5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000022809
Description

Other designations: cAMP-dependent transcription factor ATF-5|cyclic AMP-dependent transcription factor ATF-5|transcription factor ATFx
Super-classes obo:OGG_2060009606c

DNAJC8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000022826
Description

Other designations: dnaJ homolog subfamily C member 8|splicing protein spf31
Super-classes obo:OGG_2060009606c

PPM1Ec # Classes

URI http://purl.obolibrary.org/obo/OGG_3000022843
Description

Other designations: ca(2+)/calmodulin-dependent protein kinase phosphatase N|caMKP-nucleus|nuclear calmodulin-dependent protein kinase phosphatase|partner of PIX 1|partner of PIX-alpha|partner of PIXA|protein phosphatase 1E|protein phosphatase 1E (PP2C domain containing)
Super-classes obo:OGG_2060009606c

NLRP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000022861
Description

Other designations: NACHT, LRR and PYD containing protein 1|NACHT, LRR and PYD domains-containing protein 1|NACHT, leucine rich repeat and PYD (pyrin domain) containing 1|NACHT, leucine rich repeat and PYD containing 1|caspase recruitment domain protein 7|caspase recruitment domain-containing protein 7|death effector filament-forming Ced-4-like apoptosis protein|nucleotide-binding domain and caspase recruitment domain|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
Super-classes obo:OGG_2060009606c

ATF6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000022926
Description

Other designations: cAMP-dependent transcription factor ATF-6 alpha|cyclic AMP-dependent transcription factor ATF-6 alpha
Super-classes obo:OGG_2060009606c

AKR7A3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000022977
Description

Other designations: AFB1 aldehyde reductase 2|AFB1-AR 2|aflatoxin B1 aldehyde reductase 2|aflatoxin B1 aldehyde reductase member 3
Super-classes obo:OGG_2060009606c

TTC39Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000022996
Description

Other designations: TPR repeat protein 39A|differentially expressed in MCF7 with estradiol protein 6|tetratricopeptide repeat protein 39A
Super-classes obo:OGG_2060009606c

JMJD6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023210
Description

Other designations: bifunctional arginine demethylase and lysyl-hydroxylase JMJD6|histone arginine demethylase JMJD6|jmjC domain-containing protein 6|jumonji domain-containing protein 6|lysyl-hydroxylase JMJD6|peptide-lysine 5-dioxygenase JMJD6|phosphatidylserine receptor
Super-classes obo:OGG_2060009606c

DNAJC9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023234
Description

Other designations: DnaJ protein SB73|dnaJ homolog subfamily C member 9
Super-classes obo:OGG_2060009606c

DNAJC13c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023317
Description

Other designations: DnaJ domain-containing protein RME-8|RME-8|dnaJ homolog subfamily C member 13|required for receptor-mediated endocytosis 8
Super-classes obo:OGG_2060009606c

DNAJC16c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023341
Description

Other designations: dnaJ homolog subfamily C member 16|novel DnaJ domain-containing protein
Super-classes obo:OGG_2060009606c

ANGPTL2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023452
Description

Other designations: angiopoietin-like protein 2|angiopoietin-related protein 2
Super-classes obo:OGG_2060009606c

QPRTc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023475
Description

Other designations: QAPRTase|epididymis secretory sperm binding protein Li 90n|nicotinate-nucleotide pyrophosphorylase (carboxylating)|nicotinate-nucleotide pyrophosphorylase [carboxylating]
Super-classes obo:OGG_2060009606c

CASP14c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023581
Description

Other designations: CASP-14|apoptosis-related cysteine protease|caspase 14, apoptosis-related cysteine protease|caspase-14
Super-classes obo:OGG_2060009606c

ORC6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023594
Description

Other designations: origin recognition complex subunit 6
Super-classes obo:OGG_2060009606c

ACOT9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023597
Description

Other designations: acyl-CoA thioester hydrolase 9|acyl-Coenzyme A thioesterase 2, mitochondrial|acyl-coenzyme A thioesterase 9, mitochondrial|mitochondrial Acyl-CoA Thioesterase
Super-classes obo:OGG_2060009606c

PPP1R15Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023645
Description

Other designations: growth arrest and DNA damage-inducible protein GADD34|growth arrest and DNA-damage-inducible 34|myeloid differentiation primary response protein MyD116 homolog|protein phosphatase 1 regulatory subunit 15A|protein phosphatase 1, regulatory (inhibitor) subunit 15A
Super-classes obo:OGG_2060009606c

PLA2G15c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023659
Description

Other designations: 1-O-acylceramide synthase|LCAT-like lysophospholipase|group XV phospholipase A2|lysophospholipase 3 (lysosomal phospholipase A2)|lysosomal phospholipase A2
Super-classes obo:OGG_2060009606c

SDF2L1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023753
Description

Other designations: OTTHUMT00000075032|PWP1-interacting protein 8|SDF2-like 1|SDF2-like protein 1|dihydropyrimidinase-like 2|stromal cell-derived factor 2-like protein 1
Super-classes obo:OGG_2060009606c

GABARAPL3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000023766
Description

GABA(A) receptors associated protein like 3, pseudogene
Super-classes obo:OGG_2070009606c

DNAJB5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000025822
Description

Other designations: dnaJ homolog subfamily B member 5|heat shock cognate 40|heat shock protein Hsp40-2|heat shock protein Hsp40-3|heat shock protein cognate 40
Super-classes obo:OGG_2060009606c

POU2F3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000025833
Description

Other designations: POU domain transcription factor OCT11a|POU domain, class 2, transcription factor 3|octamer-binding protein 11|octamer-binding transcription factor 11|transcription factor PLA-1|transcription factor Skn-1
Super-classes obo:OGG_2060009606c

TSKUc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000025987
Description

Other designations: E2-induced gene 4 protein|leucine rich repeat containing 54|leucine-rich repeat-containing protein 54|tsukushi homolog|tsukushi small leucine rich proteoglycan homolog|tsukushin
Super-classes obo:OGG_2060009606c

ACOT11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000026027
Description

Other designations: START domain containing 14|StAR-related lipid transfer (START) domain containing 14|acyl-CoA thioester hydrolase 11|acyl-coenzyme A thioesterase 11|adipose-associated thioesterase|brown fat-inducible thioesterase|thioesterase superfamily member 1|thioesterase, adipose associated
Super-classes obo:OGG_2060009606c

HACL1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000026061
Description

Other designations: 1600020H07Rik|2-hydroxyphytanol-CoA lyase|2-hydroxyphytanoyl-CoA lyase|phytanoyl-CoA 2-hydroxylase 2|phytanoyl-CoA hydroxylase 2
Super-classes obo:OGG_2060009606c

ARFGAP3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000026286
Description

Other designations: ADP-ribosylation factor GTPase activating protein 1|ADP-ribosylation factor GTPase-activating protein 3|ARF GAP 3
Super-classes obo:OGG_2060009606c

FGF21c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000026291
Description

fibroblast growth factor 21
Super-classes obo:OGG_2060009606c

INTS6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000026512
Description

Other designations: DEAD box protein|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26|RNA helicase HDB|protein deleted in cancer 1
Super-classes obo:OGG_2060009606c

CHORDC1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000026973
Description

Other designations: CHORD-containing protein 1|CHP-1|chord domain-containing protein 1|cysteine and histidine-rich domain (CHORD)-containing 1|cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1|cysteine and histidine-rich domain-containing protein 1|protein morgana
Super-classes obo:OGG_2060009606c

DNAJC2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027000
Description

Other designations: M-phase phosphoprotein 11|dnaJ homolog subfamily C member 2|zuotin related factor 1|zuotin-related factor 1
Super-classes obo:OGG_2060009606c

EIF2AK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027102
Description

Other designations: heme regulated initiation factor 2 alpha kinase|heme sensitive initiation factor 2a kinase|heme-controlled repressor|heme-regulated eukaryotic initiation factor eIF-2-alpha kinase|heme-regulated inhibitor|heme-regulated initiation factor 2-alpha kinase|heme-regulated repressor|hemin-sensitive initiation factor 2-alpha kinase
Super-classes obo:OGG_2060009606c

BBS9c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027241
Description

Other designations: PTH-responsive osteosarcoma B1 protein|bardet-Biedl syndrome 9 protein|parathyroid hormone-responsive B1 gene protein|protein PTHB1
Super-classes obo:OGG_2060009606c

TNFRSF21c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027242
Description

Other designations: TNFR-related death receptor 6|death receptor 6|tumor necrosis factor receptor superfamily member 21
Super-classes obo:OGG_2060009606c

SESN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027244
Description

Other designations: p53 activated gene 26|p53 regulated PA26 nuclear protein|sestrin-1
Super-classes obo:OGG_2060009606c

SRPX2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027286
Description

Other designations: sushi repeat-containing protein SRPX2|sushi-repeat protein up-regulated in leukemia|sushi-repeat protein upregulated in leukemia|sushi-repeat-containing protein, X-linked 2
Super-classes obo:OGG_2060009606c

ANGPTL3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027329
Description

Other designations: angiopoietin 5|angiopoietin-related protein 3
Super-classes obo:OGG_2060009606c

EIF3Kc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000027335
Description

Other designations: eIF-3 p25|eIF-3 p28|eukaryotic translation initiation factor 3 subunit 12|eukaryotic translation initiation factor 3 subunit K|eukaryotic translation initiation factor 3, subunit 12|muscle specific|muscle-specific gene M9 protein
Super-classes obo:OGG_2060009606c

ATAD2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029028
Description

Other designations: AAA nuclear coregulator cancer-associated protein|ATPase family AAA domain-containing protein 2
Super-classes obo:OGG_2060009606c

NDUFAF4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029078
Description

Other designations: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4|NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4|hormone-regulated proliferation-associated protein of 20 kDa|hormone-regulated proliferation-associated protein, 20 kDa
Super-classes obo:OGG_2060009606c

UBE2Tc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029089
Description

Other designations: HSPC150 protein similar to ubiquitin-conjugating enzyme|cell proliferation-inducing gene 50 protein|ubiquitin carrier protein T|ubiquitin conjugating enzyme|ubiquitin-conjugating enzyme E2 T|ubiquitin-protein ligase T
Super-classes obo:OGG_2060009606c

DNAJC15c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029103
Description

Other designations: DNAJ domain-containing|DnaJ (Hsp40) homolog, subfamily D, member 1|cell growth-inhibiting gene 22 protein|dnaJ homolog subfamily C member 15|methylation-controlled J protein
Super-classes obo:OGG_2060009606c

DDX25c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029118
Description

Other designations: ATP-dependent RNA helicase DDX25|DEAD (Asp-Glu-Ala-Asp) box polypeptide 25|DEAD box protein 25|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 25|gonadotropin-regulated testicular RNA helicase
Super-classes obo:OGG_2060009606c

UHRF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029128
Description

Other designations: E3 ubiquitin-protein ligase UHRF1|RING finger protein 106|inverted CCAAT box-binding protein of 90 kDa|nuclear phosphoprotein 95|nuclear protein 95|nuclear zinc finger protein Np95|transcription factor ICBP90|ubiquitin-like PHD and RING finger domain-containing protein 1|ubiquitin-like, containing PHD and RING finger domains, 1
Super-classes obo:OGG_2060009606c

CYP2S1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029785
Description

Other designations: CYPIIS1|cytochrome P450 2S1|cytochrome P450 family member predicted from ESTs|cytochrome P540, subfamily IIS, polypeptide 1
Super-classes obo:OGG_2060009606c

TRA2Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029896
Description

Other designations: TRA-2 alpha|TRA2-alpha|Tra2alpha|htra-2 alpha|htra-2-alpha|putative MAPK activating protein PM24|transformer-2 alpha|transformer-2 protein homolog A|transformer-2 protein homolog alpha
Super-classes obo:OGG_2060009606c

HILPDAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029923
Description

Other designations: hypoxia inducible gene 2|hypoxia-inducible gene 2 protein|hypoxia-inducible lipid droplet-associated protein|hypoxia-inducible protein 2
Super-classes obo:OGG_2060009606c

OSGIN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000029948
Description

Other designations: bone marrow stromal cell-derived growth inhibitor|ovary, kidney and liver protein 38|oxidative stress-induced growth inhibitor 1|pregnancy-induced growth inhibitor OKL38
Super-classes obo:OGG_2060009606c

SCAPERc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000049855
Description

Other designations: S phase cyclin A-associated protein in the ER|S phase cyclin A-associated protein in the endoplasmic reticulum|zinc finger protein 291
Super-classes obo:OGG_2060009606c

HDGFRP3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000050810
Description

Other designations: hepatoma-derived growth factor 2|hepatoma-derived growth factor-related protein 3
Super-classes obo:OGG_2060009606c

ANGPTL4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051129
Description

Other designations: PPARG angiopoietin related protein|angiopoietin-related protein 4|fasting-induced adipose factor|hepatic angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
Super-classes obo:OGG_2060009606c

INSIG2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051141
Description

Other designations: INSIG-2|INSIG2 membrane protein|insulin induced protein 2|insulin-induced gene 2 protein
Super-classes obo:OGG_2060009606c

ING4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051147
Description

Other designations: brain my036 protein|candidate tumor suppressor p33 ING1 homolog|inhibitor of growth protein 4
Super-classes obo:OGG_2060009606c

C6orf203c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051250
Description

Other designations: uncharacterized protein C6orf203
Super-classes obo:OGG_2060009606c

DNAJC27c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051277
Description

Other designations: Ras-associated protein Rap1|dnaJ homolog subfamily C member 27|rab and DnaJ domain-containing protein
Super-classes obo:OGG_2060009606c

CYP39A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051302
Description

Other designations: 24-hydroxycholesterol 7-alpha-hydroxylase|cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1
Super-classes obo:OGG_2060009606c

TNFRSF12Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051330
Description

Other designations: FGF-inducible 14|fibroblast growth factor-inducible immediate-early response protein 14|tumor necrosis factor receptor superfamily member 12A|tweak-receptor|type I transmembrane protein Fn14
Super-classes obo:OGG_2060009606c

ANGPT4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051378
Description

Other designations: ANG-4|angiopoietin-3|angiopoietin-4|dJ824F16.2 (angiopoietin 4)
Super-classes obo:OGG_2060009606c

EIF3Lc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051386
Description

Other designations: eIEF associated protein HSPC021|eukaryotic translation initiation factor 3 subunit 6-interacting protein|eukaryotic translation initiation factor 3 subunit E-interacting protein|eukaryotic translation initiation factor 3 subunit L
Super-classes obo:OGG_2060009606c

AIG1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051390
Description

Other designations: androgen-induced gene 1 protein
Super-classes obo:OGG_2060009606c

ISYNA1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051477
Description

Other designations: MI-1-P synthase|MIP synthase|myo-inositol 1-phosphate synthase A1
Super-classes obo:OGG_2060009606c

GTSE1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051512
Description

Other designations: G2 and S phase-expressed protein 1|protein B99 homolog
Super-classes obo:OGG_2060009606c

NBASc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051594
Description

Other designations: NAG/BC035112 fusion|NAG/FAM49A fusion|neuroblastoma-amplified gene protein|neuroblastoma-amplified sequence
Super-classes obo:OGG_2060009606c

DNAJB11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000051726
Description

Other designations: APOBEC1-binding protein 2|DnaJ protein 9|ER-associated DNAJ protein 3|ER-associated Hsp40 co-chaperone|ER-resident protein ERdj3|PWP1-interacting protein 4|dnaJ homolog subfamily B member 11|endoplasmic reticulum DNA J domain-containing protein 3
Super-classes obo:OGG_2060009606c

PANK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000053354
Description

Other designations: pantothenic acid kinase 1
Super-classes obo:OGG_2060009606c

DNAJC10c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000054431
Description

Other designations: ER-resident protein ERdj5|J-domain-containing protein disulfide isomerase-like protein|dnaJ homolog subfamily C member 10|endoplasmic reticulum DNA J domain-containing protein 5|macrothioredoxin|protein disulfide isomerase family A, member 19
Super-classes obo:OGG_2060009606c

DDIT4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000054541
Description

Other designations: DNA damage-inducible transcript 4 protein|HIF-1 responsive protein RTP801|protein regulated in development and DNA damage response 1
Super-classes obo:OGG_2060009606c

UGT1A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000054658
Description

Other designations: UDP glycosyltransferase 1 family, polypeptide A1|UDP-glucuronosyltransferase 1-1|UDP-glucuronosyltransferase 1-A|UDP-glucuronosyltransferase 1A1|UGT-1A|UGT1*1|UGT1-01|UGT1.1|bilirubin UDP-glucuronosyltransferase 1-1|bilirubin UDP-glucuronosyltransferase isozyme 1|bilirubin-specific UDPGT isozyme 1
Super-classes obo:OGG_2060009606c

DNAJB12c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000054788
Description

Other designations: dnaJ homolog subfamily B member 12
Super-classes obo:OGG_2060009606c

CYP2W1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000054905
Description

Other designations: CYPIIW1|cytochrome P450 2W1
Super-classes obo:OGG_2060009606c

DNAJC28c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000054943
Description

Other designations: dnaJ homolog subfamily C member 28
Super-classes obo:OGG_2060009606c

COMMD8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000054951
Description

Other designations: COMM domain-containing protein 8
Super-classes obo:OGG_2060009606c

SLC38A4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055089
Description

Other designations: N amino acid transporter 3|Na(+)-coupled neutral amino acid transporter 4|amino acid transporter A3|amino acid transporter system A3|sodium-coupled neutral amino acid transporter 4|system A amino acid transporter 3|system N amino acid transporter 3
Super-classes obo:OGG_2060009606c

AGGF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055109
Description

Other designations: G patch domain-containing protein 7|angiogenic factor VG5Q|vasculogenesis gene on 5q protein
Super-classes obo:OGG_2060009606c

NUDT11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055190
Description

Other designations: DIPP-3-beta|DIPP3-beta|diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta|diadenosine hexaphosphate hydrolase (AMP-forming)|diphosphoinositol polyphosphate phosphohydrolase 3, beta|diphosphoinositol polyphosphate phosphohydrolase 3-beta|hAps1|nucleoside diphosphate-linked moiety X motif 11|nudix motif 11
Super-classes obo:OGG_2060009606c

DNAJC17c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055192
Description

Other designations: dnaJ homolog subfamily C member 17
Super-classes obo:OGG_2060009606c

ETNK2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055224
Description

Other designations: EKI 2|ethanolamine kinase-like protein
Super-classes obo:OGG_2060009606c

ACOXLc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055289
Description

Other designations: acyl-CoA oxidase-like protein|acyl-coenzyme A oxidase-like protein
Super-classes obo:OGG_2060009606c

SPTLC3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055304
Description

Other designations: LCB 3|SPT 3|long chain base biosynthesis protein 2b|long chain base biosynthesis protein 3|serine palmitoyltransferase 3|serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)|serine-palmitoyl-CoA transferase 3
Super-classes obo:OGG_2060009606c

ACER3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055331
Description

Other designations: alkCDase 3|alkaline CDase 3|alkaline dihydroceramidase SB89|alkaline phytoceramidase|phytoceramidase, alkaline
Super-classes obo:OGG_2060009606c

VNN3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055350
Description

vanin 3
Super-classes obo:OGG_2070009606c

CNOT11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055571
Description

Other designations: CCR4-NOT transcription complex subunit 11|UPF0760 protein C2orf29
Super-classes obo:OGG_2060009606c

PNRC2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055629
Description

proline-rich nuclear receptor coactivator 2
Super-classes obo:OGG_2060009606c

G2E3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055632
Description

Other designations: G2/M phase-specific E3 ubiquitin-protein ligase|G2/M-phase specific E3 ubiquitin ligase|PHD finger protein 7B
Super-classes obo:OGG_2060009606c

ATF7IPc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055729
Description

Other designations: ATF-interacting protein|ATF7-interacting protein|ATFa-associated modulator|MBD1-containing chromatin-associated factor 1|activating transcription factor 7-interacting protein 1
Super-classes obo:OGG_2060009606c

DNAJC11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055735
Description

Other designations: dnaJ homolog subfamily C member 11|novel DnaJ domain-containing protein
Super-classes obo:OGG_2060009606c

EDEM2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055741
Description

Other designations: ER degradation-enhancing alpha-mannosidase-like 2|ER degradation-enhancing alpha-mannosidase-like protein 2|ER degradation-enhancing-mannosidase-like protein 2
Super-classes obo:OGG_2060009606c

RNF130c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055819
Description

Other designations: E3 ubiquitin-protein ligase RNF130|g1-related zinc finger protein|goliath homolog
Super-classes obo:OGG_2060009606c

ACOT13c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000055856
Description

Other designations: acyl-coenzyme A thioesterase 13|hypothalamus protein HT012|thioesterase superfamily member 2
Super-classes obo:OGG_2060009606c

EIF4ENIF1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000056478
Description

Other designations: 2610509L04Rik|eIF4E transporter|eIF4E-transporter|eukaryotic translation initiation factor 4E transporter
Super-classes obo:OGG_2060009606c

DNAJC12c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000056521
Description

Other designations: J domain containing protein 1 (JDP1)|J domain protein 1|dnaJ homolog subfamily C member 12|j domain-containing protein 1
Super-classes obo:OGG_2060009606c

CYP26B1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000056603
Description

Other designations: cytochrome P450 26B1|cytochrome P450 retinoic acid-inactivating 2|cytochrome P450 retinoid metabolizing protein|cytochrome P450, subfamily XXVIB, polypeptide 1|retinoic acid-metabolizing cytochrome
Super-classes obo:OGG_2060009606c

ERO1LBc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000056605
Description

Other designations: ERO1-L-beta|ERO1-like protein beta|endoplasmic oxidoreductin-1-like protein B|endoplasmic reticulum oxidoreductin-1-like protein B|oxidoreductin-1-L-beta
Super-classes obo:OGG_2060009606c

EIF5A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000056648
Description

Other designations: eIF-5A-2|eukaryotic initiation factor 5A|eukaryotic translation initiation factor 5A-2
Super-classes obo:OGG_2060009606c

STARD7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000056910
Description

Other designations: START domain containing 7|START domain-containing protein 7|gestational trophoblastic tumor protein 1|stAR-related lipid transfer protein 7, mitochondrial
Super-classes obo:OGG_2060009606c

SLC44A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000057153
Description

Other designations: choline transporter-like protein 2|solute carrier family 44, member 2
Super-classes obo:OGG_2060009606c

VANGL2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000057216
Description

Other designations: loop-tail protein 1 homolog|loop-tail-associated protein|strabismus 1|van Gogh-like protein 2|vang-like 2 (van gogh, Drosophila)|vang-like protein 2
Super-classes obo:OGG_2060009606c

CYP20A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000057404
Description

Other designations: cytochrome P450 20A1|cytochrome P450 monooxygenase
Super-classes obo:OGG_2060009606c

PDP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000057546
Description

Other designations: PDPC 2|[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial|protein phosphatase 2C, magnesium-dependent, catalytic subunit 2|pyruvate dehydrogenase phosphatase catalytic subunit 2|pyruvate dehydrogenase phosphatase isoenzyme 2|pyruvate dehydrogenase phosphatase, catalytic subunit 2
Super-classes obo:OGG_2060009606c

FNIP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000057600
Description

Other designations: FNIP1-like protein|O6-methylguanine-induced apoptosis 1 protein|folliculin-interacting protein 2
Super-classes obo:OGG_2060009606c

TRIB3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000057761
Description

Other designations: TRB-3|neuronal cell death inducible putative kinase|neuronal cell death-inducible putative kinase|p65-interacting inhibitor of NF-kappa-B|p65-interacting inhibitor of NF-kappaB|tribbles homolog 3
Super-classes obo:OGG_2060009606c

CYP4F11c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000057834
Description

Other designations: cytochrome P450 4F11|cytochrome P450, subfamily IVF, polypeptide 11
Super-classes obo:OGG_2060009606c

AFAP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000060312
Description

Other designations: 110 kDa actin filament-associated protein|actin filament-associated protein 1|actin filament-associated protein, 110 kDa
Super-classes obo:OGG_2060009606c

ZNF667c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000063934
Description

Other designations: myocardial ischemic preconditioning upregulated 1 ortholog
Super-classes obo:OGG_2060009606c

PBLDc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064081
Description

Other designations: MAWD-binding protein|phenazine biosynthesis-like domain-containing protein
Super-classes obo:OGG_2060009606c

DNAJC1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064215
Description

Other designations: DnaJ-like protein|dnaJ homolog subfamily C member 1|dnaJ protein homolog MTJ1
Super-classes obo:OGG_2060009606c

ABCG8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064241
Description

Other designations: ATP-binding cassette sub-family G member 8|ATP-binding cassette, subfamily G, member 8|sterolin 2|sterolin-2
Super-classes obo:OGG_2060009606c

LMBR1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064327
Description

Other designations: differentiation-related gene 14 protein|limb region 1 homolog|limb region 1 protein homolog
Super-classes obo:OGG_2060009606c

NFKBIZc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064332
Description

Other designations: I-kappa-B-zeta|IL-1 inducible nuclear ankyrin-repeat protein|Ikappa B-zeta variant 3|IkappaB-zeta|NF-kappa-B inhibitor zeta|ikB-zeta|ikappaBzeta|molecule possessing ankyrin repeats induced by lipopolysaccharide
Super-classes obo:OGG_2060009606c

HIF3Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064344
Description

Other designations: HIF3-alpha-1|PAS domain-containing protein 7|basic-helix-loop-helix-PAS protein MOP7|class E basic helix-loop-helix protein 17|hypoxia-inducible factor 3-alpha|inhibitory PAS domain protein|member of PAS protein 7
Super-classes obo:OGG_2060009606c

AENc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064782
Description

Other designations: apoptosis-enhancing nuclease|interferon stimulated exonuclease gene 20kDa-like 1|interferon-stimulated 20 kDa exonuclease-like 1
Super-classes obo:OGG_2060009606c

EPS8L2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064787
Description

Other designations: EPS8-like protein 2|EPS8-related protein 2|epidermal growth factor receptor kinase substrate 8-like protein 2|epidermal growth factor receptor pathway substrate 8-related protein 2
Super-classes obo:OGG_2060009606c

CYP3A43c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064816
Description

Other designations: cytochrome P450 3A43|cytochrome P450, subfamily IIIA, polypeptide 43
Super-classes obo:OGG_2060009606c

FNDC4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000064838
Description

Other designations: fibronectin type III domain-containing protein 4|fibronectin type III repeat-containing protein 1
Super-classes obo:OGG_2060009606c

DDRGK1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000065992
Description

Other designations: DDRGK domain-containing protein 1|Dashurin|UFM1-binding protein 1 containing a PCI domain
Super-classes obo:OGG_2060009606c

CYP4F12c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000066002
Description

Other designations: CYPIVF12|cytochrome P450 4F12|cytochrome P450, subfamily IVF, polypeptide 12
Super-classes obo:OGG_2060009606c

ELOVL6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079071
Description

Other designations: 3-keto acyl-CoA synthase ELOVL6|ELOVL FA elongase 6|ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)|elongation of very long chain fatty acids protein 6|fatty acid elongase 2|fatty acyl-CoA elongase|hELO2|long-chain fatty-acyl elongase|very-long-chain 3-oxoacyl-CoA synthase 6
Super-classes obo:OGG_2060009606c

CHAC1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079094
Description

Other designations: ChaC, cation transport regulator-like 1|blocks Notch protein|botch|cation transport regulator-like protein 1|gamma-GCT acting on glutathione homolog 1
Super-classes obo:OGG_2060009606c

CRELD2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079174
Description

Other designations: cysteine-rich with EGF-like domain protein 2
Super-classes obo:OGG_2060009606c

CLMNc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079789
Description

Other designations: calmin|calponin like transmembrane domain protein|calponin-like transmembrane domain protein
Super-classes obo:OGG_2060009606c

UGT2A3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079799
Description

Other designations: UDP-glucuronosyltransferase 2A3|UDPGT 2A3
Super-classes obo:OGG_2060009606c

ZC3H14c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079882
Description

Other designations: mammalian suppressor of tau pathology-2|nuclear protein UKp68|renal carcinoma antigen NY-REN-37|zinc finger CCCH domain-containing protein 14
Super-classes obo:OGG_2060009606c

DNAJC22c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079962
Description

Other designations: dnaJ homolog subfamily C member 22|wurst homolog
Super-classes obo:OGG_2060009606c

DNAJB14c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000079982
Description

Other designations: dnaJ homolog subfamily B member 14
Super-classes obo:OGG_2060009606c

ATF7IP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000080063
Description

Other designations: ATF7-interacting protein 2|MBD1-containing chromatin associated factor 2|MBD1-containing chromatin-associated factor 2|activating transcription factor 7-interacting protein 2
Super-classes obo:OGG_2060009606c

PIGZc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000080235
Description

Other designations: GPI mannosyltransferase 4|GPI mannosyltransferase IV|SMP3 mannosyltransferase|dol-P-Man dependent GPI mannosyltransferase|phosphatidylinositol glycan, class Z|phosphatidylinositol-glycan biosynthesis class Z protein
Super-classes obo:OGG_2060009606c

SLC35F5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000080255
Description

Other designations: HCV NS5A-transactivated protein 3|hepatitis C virus NS5A-transactivated protein 3|solute carrier family 35 member F5
Super-classes obo:OGG_2060009606c

EDEM3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000080267
Description

Other designations: ER degradation-enhancing -mannosidase-like protein 3|ER degradation-enhancing alpha-mannosidase-like 3|ER degradation-enhancing alpha-mannosidase-like protein 3|alpha-1,2-mannosidase EDEM3
Super-classes obo:OGG_2060009606c

DNAJC5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000080331
Description

Other designations: cysteine string protein alpha|dnaJ homolog subfamily C member 5
Super-classes obo:OGG_2060009606c

APOLD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000081575
Description

Other designations: apolipoprotein L domain-containing protein 1|vascular early response gene protein
Super-classes obo:OGG_2060009606c

RAB33Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000083452
Description

Other designations: ras-related protein Rab-33B
Super-classes obo:OGG_2060009606c

RHNO1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000083695
Description

Other designations: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1|Rad9, Rad1, Hus1 interacting nuclear orphan|rAD9, RAD1, HUS1-interacting nuclear orphan protein
Super-classes obo:OGG_2060009606c

INHBEc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000083729
Description

Other designations: activin beta E|activin beta-E chain|inhibin beta E chain
Super-classes obo:OGG_2060009606c

ANGPTL6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000083854
Description

Other designations: angiopoietin-like protein 6|angiopoietin-related growth factor|angiopoietin-related protein 5|angiopoietin-related protein 6
Super-classes obo:OGG_2060009606c

EIF2Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000083939
Description

Other designations: 65 kDa eukaryotic translation initiation factor 2A|eukaryotic translation initiation factor 2A
Super-classes obo:OGG_2060009606c

FBXO30c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084085
Description

Other designations: F-box domain protein|F-box only protein 30|F-box only protein, helicase, 18
Super-classes obo:OGG_2060009606c

HSDL2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084263
Description

Other designations: hydroxysteroid dehydrogenase-like protein 2|short chain dehydrogenase/reductase family 13C, member 1
Super-classes obo:OGG_2060009606c

DNAJC30c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084277
Description

Other designations: Williams Beuren syndrome chromosome region 18|dnaJ homolog subfamily C member 30|williams-Beuren syndrome chromosomal region 18 protein
Super-classes obo:OGG_2060009606c

EIF1ADc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084285
Description

Other designations: eukaryotic translation initiation factor 1A domain-containing protein|probable RNA-binding protein EIF1AD
Super-classes obo:OGG_2060009606c

ACBD6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084320
Description

Other designations: acyl-CoA-binding domain-containing protein 6|acyl-Coenzyme A binding domain containing 6
Super-classes obo:OGG_2060009606c

DGAT2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084649
Description

Other designations: acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase homolog 2|diacylglycerol O-acyltransferase-like protein 2|diglyceride acyltransferase 2|retinol O-fatty-acyltransferase
Super-classes obo:OGG_2060009606c

TRIM55c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084675
Description

Other designations: muscle specific ring finger 2|muscle-specific RING finger protein 2|ring finger protein 29|tripartite motif-containing 55|tripartite motif-containing protein 55
Super-classes obo:OGG_2060009606c

ABHD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000084696
Description

Other designations: abhydrolase domain-containing protein 1|lung alpha/beta hydrolase 1
Super-classes obo:OGG_2060009606c

DNAJC14c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000085406
Description

Other designations: LYST-interacting protein LIP6|dnaJ homolog subfamily C member 14|dnaJ protein homolog 3|dopamine receptor interacting protein|dopamine receptor-interacting protein of 78 kDa|hDj-3|human DnaJ protein 3
Super-classes obo:OGG_2060009606c

DNAJC5Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000085479
Description

Other designations: beta cysteine string protein|beta-CSP|cysteine string protein beta|dnaJ homolog subfamily C member 5B|dnaJ homolog subfamily C member X
Super-classes obo:OGG_2060009606c

DPH6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000089978
Description

Other designations: ATP binding domain 4|ATP-binding domain-containing protein 4|DPH6 homolog|diphthamide synthase|diphthamide synthetase|diphthine--ammonia ligase|protein DPH6 homolog
Super-classes obo:OGG_2060009606c

ZFAND2Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000090637
Description

Other designations: AN1-type zinc finger protein 2A|arsenite inducible RNA associated protein
Super-classes obo:OGG_2060009606c

LRRC16Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000090668
Description

Other designations: leucine-rich repeat-containing protein 16B
Super-classes obo:OGG_2060009606c

CCDC126c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000090693
Description

Other designations: coiled-coil domain-containing protein 126
Super-classes obo:OGG_2060009606c

RSAD2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000091543
Description

Other designations: cytomegalovirus-induced gene 5 protein|radical S-adenosyl methionine domain-containing protein 2|viperin|virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Super-classes obo:OGG_2060009606c

LEMD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000093273
Description

Other designations: LEM domain protein 1|LEM domain-containing protein 1|cancer/testis antigen 50
Super-classes obo:OGG_2060009606c

TP53INP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000094241
Description

Other designations: p53-dependent damage-inducible nuclear protein 1|p53-inducible p53DINP1|stress-induced protein|tumor protein p53-inducible nuclear protein 1
Super-classes obo:OGG_2060009606c

PRRT2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000112476
Description

Other designations: dispanin subfamily B member 3|infantile convulsions and paroxysmal choreoathetosis|interferon induced transmembrane protein domain containing 1
Super-classes obo:OGG_2060009606c

L3HYPDHc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000112849
Description

Other designations: probable proline racemase|trans-3-hydroxy-l-proline dehydratase|trans-3-hydroxyl-L-proline dehydratase|trans-L-3-hydroxyproline dehydratase
Super-classes obo:OGG_2060009606c

CDCA5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000113130
Description

Other designations: cell division cycle-associated protein 5|p35|sororin
Super-classes obo:OGG_2060009606c

CYP2U1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000113612
Description

Other designations: cytochrome P450 2U1|spastic paraplegia 49
Super-classes obo:OGG_2060009606c

FHAD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000114827
Description

Other designations: FHA domain-containing protein 1|forkhead-associated domain-containing protein 1
Super-classes obo:OGG_2060009606c

DDIT4Lc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000115265
Description

Other designations: DNA damage-inducible transcript 4-like protein|HIF-1 responsive protein RTP801-like|REDD-2|homolog of mouse SMHS1|protein regulated in development and DNA damage response 2|regulated in development and DNA damage response 2
Super-classes obo:OGG_2060009606c

NUS1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000116150
Description

Other designations: nogo-B receptor|transport and golgi organization 14 homolog
Super-classes obo:OGG_2060009606c

LEAP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000116842
Description

Other designations: liver-expressed antimicrobial peptide 2
Super-classes obo:OGG_2060009606c

CYP2R1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000120227
Description

Other designations: cytochrome P450 2R1|cytochrome P450, family 2, R1|vitamin D 25-hydroxylase
Super-classes obo:OGG_2060009606c

DNAJC24c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000120526
Description

Other designations: 1700030A21Rik|CSL-type zinc finger-containing protein 3|DPH4 homolog (JJJ3, S. cerevisiae)|DPH4, JJJ3 homolog|diphthamide biosynthesis protein 4|dnaJ homolog subfamily C member 24|zinc finger, CSL domain containing 3|zinc finger, CSL-type containing 3
Super-classes obo:OGG_2060009606c

PLD4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000122618
Description

Other designations: PLD 4|choline phosphatase 4|phosphatidylcholine-hydrolyzing phospholipase D4|phospholipase D4
Super-classes obo:OGG_2060009606c

ACOT4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000122970
Description

Other designations: PTE-2b|acyl-coenzyme A thioesterase 4|peroxisomal acyl coenzyme A thioester hydrolase Ib|peroxisomal acyl-CoA thioesterase 2B|peroxisomal long-chain acyl-CoA thioesterase Ib
Super-classes obo:OGG_2060009606c

HYKKc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000123688
Description

Other designations: 5-hydroxy-L-lysine kinase|5-hydroxylysine kinase|aminoglycoside phosphotransferase domain containing 1|aminoglycoside phosphotransferase domain-containing protein 1
Super-classes obo:OGG_2060009606c

ACSM2Ac # Classes

URI http://purl.obolibrary.org/obo/OGG_3000123876
Description

Other designations: Homolog of rat kidney-specific (KS)|acyl-coenzyme A synthetase ACSM2A, mitochondrial|butyrate--CoA ligase 2A|butyryl-coenzyme A synthetase 2A|middle-chain acyl-CoA synthetase 2A
Super-classes obo:OGG_2060009606c

CYP4F22c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000126410
Description

Other designations: cytochrome P450 4F22|cytochrome P450, family 2, subfamily E, polypeptide 2 homolog
Super-classes obo:OGG_2060009606c

C1orf162c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000128346
Description

Other designations: transmembrane protein C1orf162
Super-classes obo:OGG_2060009606c

TSHZ2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000128553
Description

Other designations: cell growth-inhibiting protein 7|ovarian cancer-related protein 10-2|serologically defined colon cancer antigen 33 like|teashirt family zinc finger 2|teashirt homolog 2|zinc finger protein 218
Super-classes obo:OGG_2060009606c

CMPK2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000129607
Description

Other designations: UMP-CMP kinase 2, mitochondrial|cytidylate kinase 2|mitochondrial UMP-CMP kinase|nucleoside-diphosphate kinase|thymidine monophosphate kinase 2|thymidylate kinase family LPS-inducible member
Super-classes obo:OGG_2060009606c

DNAJC19c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000131118
Description

Other designations: homolog of yeast TIM14|mitochondrial import inner membrane translocase subunit TIM14
Super-classes obo:OGG_2060009606c

JMYc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000133746
Description

Other designations: WAS protein homology region 2 domain containing 1-like 3|junction-mediating and -regulatory protein|junction-mediating and regulatory protein
Super-classes obo:OGG_2060009606c

DNAJC21c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000134218
Description

Other designations: DnaJ homology subfamily A member 5|JJJ1 DnaJ domain protein homolog|dnaJ homolog subfamily A member 5|dnaJ homolog subfamily C member 21
Super-classes obo:OGG_2060009606c

ACOT12c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000134526
Description

Other designations: START domain-containing protein 15|StAR-related lipid transfer (START) domain containing 15|acyl-CoA thioester hydrolase 12|acyl-coenzyme A thioesterase 12|cytoplasmic acetyl-CoA hydrolase 1|cytosolic acetyl-CoA hydrolase|hCACH-1
Super-classes obo:OGG_2060009606c

TMEM139c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000135932
Description

transmembrane protein 139
Super-classes obo:OGG_2060009606c

SRXN1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000140809
Description

Other designations: sulfiredoxin-1
Super-classes obo:OGG_2060009606c

EIF5AL1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000143244
Description

Other designations: eukaryotic translation initiation factor 5A pseudogene 1|eukaryotic translation initiation factor 5A-1-like
Super-classes obo:OGG_2060009606c

DNAJB7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000150353
Description

Other designations: dnaJ homolog subfamily B member 7|novel DnaJ domain protein
Super-classes obo:OGG_2060009606c

LINC00342c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000150759
Description

long intergenic non-protein coding RNA 342
Super-classes obo:OGG_2100009606c

PLB1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000151056
Description

Other designations: lysophospholipase|phospholipase A2|phospholipase B|phospholipase B/lipase|phospholipase B1, membrane-associated
Super-classes obo:OGG_2060009606c

ZNF385Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000151126
Description

Other designations: zinc finger protein 533
Super-classes obo:OGG_2060009606c

RASGEF1Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000153020
Description

Other designations: GPI gamma-4|GPI-gamma 4|ras-GEF domain-containing family member 1B
Super-classes obo:OGG_2060009606c

REM2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000161253
Description

Other designations: GTP-binding protein REM 2|Rad and Gem-related 2 (rat homolog)|rad and Gem-like GTP-binding protein 2
Super-classes obo:OGG_2060009606c

TOR1AIP2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000163590
Description

Other designations: 15 kDa interferon-responsive protein|interferon responsive gene 15|lumenal domain like LAP1|lumenal domain-like LAP1|torsin-1A-interacting protein 2
Super-classes obo:OGG_2060009606c

DNAJB8c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000165721
Description

Other designations: dnaJ homolog subfamily B member 8
Super-classes obo:OGG_2060009606c

MMAAc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000166785
Description

Other designations: methylmalonic aciduria type A protein, mitochondrial
Super-classes obo:OGG_2060009606c

BHLHA15c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000168620
Description

Other designations: MIST-1|basic helix-loop-helix domain containing, class B, 8|class A basic helix-loop-helix protein 15|class B basic helix-loop-helix protein 8|class II bHLH protein MIST1|muscle, intestine and stomach expression 1
Super-classes obo:OGG_2060009606c

PLBD2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000196463
Description

Other designations: 76 kDa protein|LAMA-like protein 2|PLB homolog 2|lamina ancestor homolog 2|mannose-6-phosphate protein associated protein p76|phospholipase B domain-containing protein 2|phospholipase B-like 2 32 kDa form|phospholipase B-like 2 45 kDa form|putative phospholipase B-like 2
Super-classes obo:OGG_2060009606c

CASP16c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000197350
Description

Other designations: putative caspase-14-like protein|putative caspase-16
Super-classes obo:OGG_2060009606c

CYP4Z1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000199974
Description

Other designations: CYPIVZ1|cytochrome P450 4Z1
Super-classes obo:OGG_2060009606c

FLCNc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000201163
Description

Other designations: BHD skin lesion fibrofolliculoma protein|birt-Hogg-Dube syndrome protein
Super-classes obo:OGG_2060009606c

DNAJC18c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000202052
Description

Other designations: dnaJ homolog subfamily C member 18
Super-classes obo:OGG_2060009606c

C9orf72c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000203228
Description

Other designations: protein C9orf72
Super-classes obo:OGG_2060009606c

CNOT6Lc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000246175
Description

Other designations: CCR4-NOT transcription complex subunit 6-like|carbon catabolite repressor protein 4 homolog B
Super-classes obo:OGG_2060009606c

EIF4E1Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000253314
Description

Other designations: eukaryotic translation initiation factor 4E type 1B
Super-classes obo:OGG_2060009606c

ANGPTL5c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000253935
Description

Other designations: angiopoietin-like protein 5|angiopoietin-related protein 5
Super-classes obo:OGG_2060009606c

FRMD3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000257019
Description

Other designations: FERM domain-containing protein 3|band 4.1-like protein 4|band 4.1-like protein 4O|ovary type protein 4.1|protein 4.1O
Super-classes obo:OGG_2060009606c

CYP4X1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000260293
Description

Other designations: cytochrome P450 4X1
Super-classes obo:OGG_2060009606c

NEAT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000283131
Description

nuclear paraspeckle assembly transcript 1 (non-protein coding)
Super-classes obo:OGG_2100009606c

NUDT7c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000283927
Description

Other designations: peroxisomal coenzyme A diphosphatase NUDT7
Super-classes obo:OGG_2060009606c

GDPD1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000284161
Description

Other designations: glycerophosphodiester phosphodiesterase 4|glycerophosphodiester phosphodiesterase domain-containing protein 1
Super-classes obo:OGG_2060009606c

CYP4A22c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000284541
Description

Other designations: CYPIVA22|cytochrome P450 4A22|cytochrome P450 4A22K|fatty acid omega-hydroxylase|lauric acid omega-hydroxylase
Super-classes obo:OGG_2060009606c

DNAJC5Gc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000285126
Description

Other designations: cysteine string protein-gamma|dnaJ homolog subfamily C member 5G|gamma cysteine string protein|gamma-CSP|gamma-cysteine string protein
Super-classes obo:OGG_2060009606c

CYP4V2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000285440
Description

Other designations: cytochrome P450 4V2
Super-classes obo:OGG_2060009606c

EIF4E3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000317649
Description

Other designations: eukaryotic translation initiation factor 4E type 3
Super-classes obo:OGG_2060009606c

EIF4BP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000319118
Description

eukaryotic translation initiation factor 4B pseudogene 1
Super-classes obo:OGG_2070009606c

CYP27C1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000339761
Description

Other designations: cytochrome P450 27C1|cytochrome P450, family 27, subfamily C, polypeptide 13
Super-classes obo:OGG_2060009606c

ACER2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000340485
Description

Other designations: alkCDase 2|alkaline CDase 2|ceramide hydrolase|haCER2
Super-classes obo:OGG_2060009606c

CYP26C1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000340665
Description

Other designations: cytochrome P450 26C1
Super-classes obo:OGG_2060009606c

IGFBPL1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000347252
Description

Other designations: IGFBP-related protein 10|insulin-like growth factor binding protein related protein 4|insulin-like growth factor-binding protein-like 1|insulin-like growth factor-binding-related protein 4
Super-classes obo:OGG_2060009606c

ACSM2Bc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000348158
Description

Other designations: acyl-CoA synthetase medium-chain family member 2|acyl-coenzyme A synthetase ACSM2B, mitochondrial|butyrate--CoA ligase 2B|butyryl-coenzyme A synthetase 2B|middle-chain acyl-CoA synthetase 2B|xenobiotic/medium-chain fatty acid-CoA ligase HXM-A|xenobiotic/medium-chain fatty acid:CoA ligase
Super-classes obo:OGG_2060009606c

SKA2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000348235
Description

Other designations: family with sequence similarity 33, member A|spindle and KT (kinetochore) associated 2|spindle and kinetochore-associated protein 2
Super-classes obo:OGG_2060009606c

ANKRD37c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000353322
Description

Other designations: ankyrin repeat domain-containing protein 37|hLrp2bp|low density lipoprotein receptor-related protein binding protein|low-density lipoprotein receptor-related protein 2-binding protein
Super-classes obo:OGG_2060009606c

NCR3LG1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000374383
Description

Other designations: B7 homolog 6|natural cytotoxicity triggering receptor 3 ligand 1|putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167
Super-classes obo:OGG_2060009606c

DNAJB13c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000374407
Description

Other designations: 1700014P03Rik|DnaJ (Hsp40) related, subfamily B, member 13|DnaJ-like protein|dnaJ homolog subfamily B member 13|radial spoke 16 homolog A|testis and spermatogenesis cell-related protein 6|testis spermatocyte apoptosis-related gene 6 protein|testis spermatogenesis apoptosis-related gene 3 protein|testis spermatogenesis apoptosis-related gene 6 protein|testis spermatogenesis apoptosis-related protein 6
Super-classes obo:OGG_2060009606c

CENPWc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000387103
Description

Other designations: cancer-up-regulated gene 2 protein|cancer-upregulated gene 2
Super-classes obo:OGG_2060009606c

INSCc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000387755
Description

Other designations: inscuteable spindle orientation adaptor protein|protein inscuteable homolog
Super-classes obo:OGG_2060009606c

OR3A4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000390756
Description

olfactory receptor family 3 subfamily A member 4 pseudogene
Super-classes obo:OGG_2100009606c
Sub-classes obo:TXPO_0004415c

MIR135A1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000406925
Super-classes obo:OGG_2100009606c
Sub-classes obo:TXPO_0004691c

MIR135A2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000406926
Super-classes obo:OGG_2100009606c
Sub-classes obo:TXPO_0004692c

MIR150c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000406942
Super-classes obo:OGG_2100009606c
Sub-classes obo:TXPO_0004887c

DNAJB3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000414061
Description

Other designations: dnaJ homolog subfamily B member 3
Super-classes obo:OGG_2060009606c

PIM3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000415116
Description

Other designations: serine/threonine kinase Pim-3|serine/threonine-protein kinase pim-3
Super-classes obo:OGG_2060009606c

EIF2AK4c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000440275
Description

Other designations: GCN2 eIF2alpha kinase|GCN2-like protein|eukaryotic translation initiation factor 2-alpha kinase 4|general control nonderepressible 2
Super-classes obo:OGG_2060009606c

TMEM150Cc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000441027
Description

transmembrane protein 150C
Super-classes obo:OGG_2060009606c

DNAJC25c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000548645
Description

Other designations: DnaJ-like protein|dnaJ homolog subfamily C member 25
Super-classes obo:OGG_2060009606c

DNAJC25-GNG10c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000552891
Description

Other designations: DNAJC25-GNG10 protein|DNAJC25-GNG10 readthrough transcript
Super-classes obo:OGG_2060009606c

ACOT1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000641371
Description

Other designations: CTE-I|CTE-Ib|acyl-coenzyme A thioesterase 1|inducible cytosolic acyl-coenzyme A thioester hydrolase|long chain acyl-CoA hydrolase|long chain acyl-CoA thioester hydrolase
Super-classes obo:OGG_2060009606c

ACOT6c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000641372
Description

Other designations: putative acyl-CoA thioesterase 6|putative acyl-coenzyme A thioesterase 6
Super-classes obo:OGG_2060009606c

EIF3CLc # Classes

URI http://purl.obolibrary.org/obo/OGG_3000728689
Description

Other designations: eIF3 p110|eIF3c|eukaryotic translation initiation factor 3 subunit 8|eukaryotic translation initiation factor 3 subunit C|eukaryotic translation initiation factor 3 subunit C-like protein|eukaryotic translation initiation factor 3, subunit 8, 110kDa-like
Super-classes obo:OGG_2060009606c

CCR2c # Classes

URI http://purl.obolibrary.org/obo/OGG_3000729230
Description

Other designations: C-C chemokine receptor type 2|MCP-1 receptor|monocyte chemoattractant protein 1 receptor|monocyte chemotactic protein 1 receptor
Super-classes obo:OGG_2060009606c

MUC3c # Classes

URI http://purl.obolibrary.org/obo/OGG_3100133790
Description

intestinal mucin-like
Super-classes obo:OGG_2060009606c

CASP12c # Classes

URI http://purl.obolibrary.org/obo/OGG_3100506742
Description

Other designations: caspase 12 pseudogene 1|inactive caspase-12
Super-classes obo:OGG_2060009606c

CYP3A7-CYP3AP1c # Classes

URI http://purl.obolibrary.org/obo/OGG_3100861540
Description

CYP3A7-CYP3AP1 readthrough
Super-classes obo:OGG_2060009606c

clinical findingc # Classes

URI http://purl.obolibrary.org/obo/OGMS_0000014
Super-classes obo:TXPO_0001503c

disease coursec # Classes

URI http://purl.obolibrary.org/obo/OGMS_0000063
Super-classes obo:TXPO_0000608c
Restrictions obo:BFO_0000051op some obo:TXPO_0000808c
obo:TXPO_0003585op some obo:DOID_4c
Sub-classes obo:OBI_1110012c
obo:OBI_1110008c
obo:TXPO_0002033c
obo:TXPO_0003587c

diagnosisc # Classes

URI http://purl.obolibrary.org/obo/OGMS_0000073
Super-classes obo:TXPO_0000614c

neoplastic cell Transformationc # Classes

URI http://purl.obolibrary.org/obo/OMIT_0003800
Super-classes obo:GO_0030154c
Sub-classes obo:TXPO_0004633c

age (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000011
Super-classes obo:PATO_0000165c

color (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000014
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000322c

color brightness qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000016
Super-classes obo:BFO_0000019c
Sub-classes obo:TXPO_0000316c
obo:PATO_0000327c

compositionc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000025
Super-classes obo:PATO_0000141c
Sub-classes obo:PATO_0002114c
obo:PATO_0002408c
obo:PATO_0001759c
obo:PATO_0001447c
obo:PATO_0002104c

directionc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000039
Super-classes obo:BFO_0000019c

hardnessc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000048
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000386c
obo:PATO_0000387c

spatial patternc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000060
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001629c

qualitative propertyc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000068
Super-classes obo:BFO_0000019c
Sub-classes obo:TXPO_0000315c

normality (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000069
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000461c
obo:PATO_0000460c

quantity (property)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000070
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000470c
obo:TXPO_0002450c

rhythm qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000078
Super-classes obo:PATO_0002323c
Sub-classes obo:PATO_0000504c
obo:PATO_0000505c

persistencec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000082
Super-classes obo:PATO_0002323c

phasec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000083
Super-classes obo:PATO_0002323c
Sub-classes obo:GO_0022403c

sizec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000117
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000586c
obo:PATO_0000915c
obo:PATO_0000119c
obo:PATO_0000122c
obo:PATO_0001323c
obo:PATO_0000918c
obo:PATO_0000587c

heightc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000119
Super-classes obo:PATO_0000117c

lengthc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000122
Super-classes obo:PATO_0000117c
Sub-classes obo:PATO_0000574c
obo:PATO_0000573c

mass (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000125
Super-classes obo:BFO_0000019c

weight (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000128
Super-classes obo:PATO_0001035c

structure (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000141
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0002037c
obo:PATO_0002269c
obo:PATO_0001850c
obo:PATO_0000025c

temperature (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000146
Super-classes obo:BFO_0000019c

time qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000165
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000011c

viabilityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000169
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001421c
obo:PATO_0001422c

red (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000322
Super-classes obo:PATO_0000014c

color brightnessc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000327
Super-classes obo:PATO_0000016c

hardc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000386
Super-classes obo:PATO_0000048c

softc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000387
Super-classes obo:PATO_0000048c

acutec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000389
Super-classes obo:PATO_0001309c
Sub-classes obo:PATO_0002091c

recurrentc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000427
Super-classes obo:PATO_0001309c

abnormalc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000460
Super-classes obo:PATO_0000069c

normalc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000461
Super-classes obo:PATO_0000069c

increased amountc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000470
Super-classes obo:PATO_0000070c

increased durationc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000498
Super-classes obo:PATO_0001309c

decreased durationc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000499
Super-classes obo:PATO_0001309c

arrhythmicc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000504
Super-classes obo:PATO_0000078c

rhythmicc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000505
Super-classes obo:PATO_0000078c

increased lengthc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000573
Super-classes obo:PATO_0000122c

decreased lengthc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000574
Super-classes obo:PATO_0000122c

hypertrophicc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000584
Super-classes obo:PATO_0000595c

increased sizec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000586
Super-classes obo:PATO_0000117c

decreased sizec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000587
Super-classes obo:PATO_0000117c
Sub-classes obo:PATO_0001623c

increased thicknessc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000591
Super-classes obo:PATO_0000915c

decreased thicknessc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000592
Super-classes obo:PATO_0000915c

increased volumec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000595
Super-classes obo:PATO_0000918c
Sub-classes obo:PATO_0000584c

decreased volumec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000596
Super-classes obo:PATO_0000918c

degenerate (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0000639
Super-classes obo:PATO_0002037c

thicknessc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000915
Super-classes obo:PATO_0000117c
Sub-classes obo:PATO_0000591c
obo:PATO_0000592c

volumec # Classes

URI http://purl.obolibrary.org/obo/PATO_0000918
Super-classes obo:PATO_0000117c
Sub-classes obo:PATO_0000595c
obo:PATO_0000596c

permeabilityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0000970
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001577c
obo:PATO_0001578c

powerc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001024
Super-classes obo:BFO_0000019c

pressurec # Classes

URI http://purl.obolibrary.org/obo/PATO_0001025
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001576c
obo:PATO_0001575c

force (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0001035
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000128c

concentratedc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001159
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001163c
obo:PATO_0001162c

increased concentrationc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001162
Super-classes obo:PATO_0001159c
Sub-classes obo:HP_0003074c

decreased concentrationc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001163
Super-classes obo:PATO_0001159c

strength qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001230
Super-classes obo:BFO_0000019c

process qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001236
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0002323c
obo:PATO_0015002c

durationc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001309
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0000499c
obo:PATO_0000498c
obo:PATO_0000389c
obo:PATO_0001417c
obo:PATO_0000427c
obo:TXPO_0002873c
obo:PATO_0001416c

areac # Classes

URI http://purl.obolibrary.org/obo/PATO_0001323
Super-classes obo:PATO_0000117c
Sub-classes obo:PATO_0002058c
obo:PATO_0002057c

reguar durationc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001416
Super-classes obo:PATO_0001309c

irregular durationc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001417
Super-classes obo:PATO_0001309c

alivec # Classes

URI http://purl.obolibrary.org/obo/PATO_0001421
Super-classes obo:PATO_0000169c

deadc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001422
Super-classes obo:PATO_0000169c

acidicc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001429
Super-classes obo:PATO_0001842c

alkalinec # Classes

URI http://purl.obolibrary.org/obo/PATO_0001430
Super-classes obo:PATO_0001842c

calcifiedc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001447
Super-classes obo:PATO_0000025c

membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001462
Super-classes obo:PATO_0001464c
Restrictions obo:RO_0000052op some obo:TXPO_0000895c
Sub-classes obo:TXPO_0000481c
obo:TXPO_0005041c

electric potentialc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001464
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001462c

flow rate qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001574
Super-classes obo:PATO_0001906c
Sub-classes obo:TXPO_0003747c
obo:TXPO_0003634c

decreased pressurec # Classes

URI http://purl.obolibrary.org/obo/PATO_0001575
Super-classes obo:PATO_0001025c

increased pressurec # Classes

URI http://purl.obolibrary.org/obo/PATO_0001576
Super-classes obo:PATO_0001025c

increased permeabilityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001577
Super-classes obo:PATO_0000970c

decreased permeabilityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001578
Super-classes obo:PATO_0000970c

atrophiedc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001623
Super-classes obo:PATO_0000587c

aggregatedc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001629
Super-classes obo:PATO_0000060c

necessity of occurrentc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001637
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001639c
obo:PATO_0001638c

necessary (occurrent)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0001638
Super-classes obo:PATO_0001637c

unnecessary (occurrent)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0001639
Super-classes obo:PATO_0001637c

granularc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001759
Super-classes obo:PATO_0000025c

decreased fluid flow (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0001838
Super-classes obo:TXPO_0003634c

increased fluid flow (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0001839
Super-classes obo:TXPO_0003634c

acidityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001842
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0001843c
obo:PATO_0001430c
obo:PATO_0001844c
obo:PATO_0001429c

decreased acidityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001843
Super-classes obo:PATO_0001842c

increased acidityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001844
Super-classes obo:PATO_0001842c

scarred (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0001850
Super-classes obo:PATO_0000141c

hydrophobicityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001884
Super-classes obo:BFO_0000019c

hydrophilicityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001886
Super-classes obo:BFO_0000019c

movement qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0001906
Super-classes obo:BFO_0000019c
Sub-classes obo:TXPO_0002462c
obo:PATO_0001574c
obo:PATO_0002242c

increased number (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0002002
Super-classes obo:TXPO_0003753c

neoplastic (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0002011
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0002132c
obo:PATO_0002096c
obo:PATO_0002098c
obo:PATO_0002129c
obo:PATO_0002097c
obo:PATO_0002473c

degeneration (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0002037
Super-classes obo:PATO_0000141c
Sub-classes obo:PATO_0000639c

increased areac # Classes

URI http://purl.obolibrary.org/obo/PATO_0002057
Super-classes obo:PATO_0001323c

decreased areac # Classes

URI http://purl.obolibrary.org/obo/PATO_0002058
Super-classes obo:PATO_0001323c
Sub-classes obo:TXPO_0003625c

affinityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002070
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0002094c
obo:TXPO_0003563c
obo:PATO_0002420c
obo:PATO_0002072c
obo:TXPO_0003518c

decreased affinityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002072
Super-classes obo:PATO_0002070c

subacutec # Classes

URI http://purl.obolibrary.org/obo/PATO_0002091
Super-classes obo:PATO_0000389c

basophilicc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002094
Super-classes obo:PATO_0002070c

neoplastic, non-malignantc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002096
Super-classes obo:PATO_0002011c

neoplastic, malignantc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002097
Super-classes obo:PATO_0002011c

neoplastic, metastaticc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002098
Super-classes obo:PATO_0002011c

inflammatoryc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002104
Super-classes obo:PATO_0000025c

fattyc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002114
Super-classes obo:PATO_0000025c

neoplastic, invasivec # Classes

URI http://purl.obolibrary.org/obo/PATO_0002129
Super-classes obo:PATO_0002011c

neoplastic, non-invasivec # Classes

URI http://purl.obolibrary.org/obo/PATO_0002132
Super-classes obo:PATO_0002011c

velocity qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002242
Super-classes obo:PATO_0001906c

accumulation (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0002269
Super-classes obo:PATO_0000141c
Sub-classes obo:PATO_0002271c
obo:PATO_0002270c

increased accumulation (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0002270
Super-classes obo:PATO_0002269c

decreased accumulation (quality)c # Classes

URI http://purl.obolibrary.org/obo/PATO_0002271
Super-classes obo:PATO_0002269c

temporal distribution qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002323
Super-classes obo:PATO_0001236c
Sub-classes obo:PATO_0000082c
obo:PATO_0000078c
obo:PATO_0000083c

activation qualityc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002353
Super-classes obo:BFO_0000019c
Sub-classes obo:PATO_0002354c
obo:PATO_0002355c

activec # Classes

URI http://purl.obolibrary.org/obo/PATO_0002354
Super-classes obo:PATO_0002353c

inactivec # Classes

URI http://purl.obolibrary.org/obo/PATO_0002355
Super-classes obo:PATO_0002353c

wateryc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002408
Super-classes obo:PATO_0000025c

amphiphilicc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002420
Super-classes obo:PATO_0002070c

neoplastic, spontaneousc # Classes

URI http://purl.obolibrary.org/obo/PATO_0002473
Super-classes obo:PATO_0002011c

process efficacyc # Classes

URI http://purl.obolibrary.org/obo/PATO_0015002
Super-classes obo:PATO_0001236c
Sub-classes obo:PATO_0015003c
obo:PATO_0015004c

decreased efficacyc # Classes

URI http://purl.obolibrary.org/obo/PATO_0015003
Super-classes obo:PATO_0015002c

increased efficacyc # Classes

URI http://purl.obolibrary.org/obo/PATO_0015004
Super-classes obo:PATO_0015002c

lipoprotein lipasec # Classes

URI http://purl.obolibrary.org/obo/PR_000009897
Super-classes obo:TXPO_0002283c

MDM2 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000000
Super-classes obo:IMR_0100660c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:TXPO_0002399c

p53 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000001
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0072331c
Sub-classes obo:TXPO_0000453c
obo:TXPO_0002369c
obo:TXPO_0001547c
obo:TXPO_0000452c

phospholipase transport to lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000002
Super-classes obo:TXPO_0000111c
Restrictions obo:RO_0002339op some obo:GO_0005764c

moving solidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000003
Super-classes obo:TXPO_0000429c
Sub-classes obo:GO_0016477c

Abcb11c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000006
Super-classes obo:TXPO_1000014c

generating periodic motionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000007
Super-classes obo:TXPO_0000765c

cell ceath [cell death (toxic course)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000008
Super-classes obo:GO_0008219c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
Sub-classes obo:TXPO_0000514c
obo:TXPO_0000512c
obo:TXPO_0002144c
obo:TXPO_0002387c

toxic coursec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000009
Super-classes obo:TXPO_0000608c
Restrictions obo:BFO_0000051op some obo:TXPO_0001715c
obo:TXPO_0000069op only obo:BFO_0000015c
obo:TXPO_0000076op only obo:BFO_0000015c
Sub-classes obo:TXPO_0000677c
obo:TXPO_0001277c
obo:TXPO_0001155c
obo:TXPO_0001357c
obo:TXPO_0003233c
obo:TXPO_0004280c
obo:TXPO_0000262c
obo:TXPO_0000501c
obo:TXPO_0002528c
obo:TXPO_0002329c
obo:TXPO_0000323c
obo:TXPO_0000028c
obo:TXPO_0001986c
obo:TXPO_0001432c
obo:TXPO_0003382c

changing membrane fluidity [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000010
Super-classes obo:TXPO_0001716c
obo:TXPO_0000412c
Restrictions obo:RO_0000057op some obo:TXPO_0001802c
obo:TXPO_0000069op some obo:TXPO_0002227c
obo:TXPO_0000069op some obo:TXPO_0002222c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000494c

generating signalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000011
Super-classes obo:TXPO_0000381c
Restrictions obo:RO_0002234op some (obo:BFO_0000002c and ub744bL41394C17c)
Sub-classes obo:TXPO_0001793c

PPARalpha activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000013
Super-classes obo:TXPO_0000158c
Restrictions obo:RO_0002234op some (obo:TXPO_0000159c and ub744bL41421C17c)
Sub-classes obo:TXPO_0004597c
obo:TXPO_0004053c
obo:TXPO_0002041c
obo:TXPO_0001005c

Sgpl1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000014
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000308c
obo:TXPO_0000819op some obo:OGG_3000008879c
Sub-classes obo:TXPO_0003529c
obo:TXPO_0002090c
obo:TXPO_0001151c

changing sensitivityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000015
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000157c
obo:TXPO_0000249c

hypofunction of detoxification [hepatic encephalopathy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000016
Super-classes obo:TXPO_0001354c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000017c

increasing ammonia concentration in blood [Hepatic encephalopathy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000017
Super-classes obo:TXPO_0001355c

ubiquitin-conjugating enzymec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000018
Super-classes obo:TXPO_0003660c

generating substancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000019
Super-classes obo:TXPO_0000381c
Sub-classes obo:GO_0046951c
obo:TXPO_0004904c
obo:TXPO_0000528c
obo:TXPO_0003780c
obo:GO_0009058c
obo:TXPO_0000382c

changing activityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000020
Super-classes obo:TXPO_0000415c
Restrictions obo:RO_0002233op some (obo:BFO_0000001c and ub744bL41492C17c)
Sub-classes obo:TXPO_0000401c
obo:TXPO_0001861c
obo:TXPO_0000021c

inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000021
Super-classes obo:TXPO_0000020c
Restrictions obo:RO_0002234op some (obo:BFO_0000001c and ub744bL41511C17c)
Sub-classes obo:TXPO_0004439c
obo:TXPO_0004900c
obo:TXPO_0004644c
obo:TXPO_0004152c
obo:TXPO_0004460c
obo:TXPO_0001589c
obo:TXPO_0002000c
obo:TXPO_0004729c
obo:TXPO_0004712c
obo:TXPO_0002947c
obo:TXPO_0001384c
obo:TXPO_0004708c
obo:TXPO_0004607c
obo:TXPO_0004466c
obo:TXPO_0004649c
obo:TXPO_0004798c
obo:TXPO_0004620c
obo:TXPO_0004747c
obo:TXPO_0004428c
obo:TXPO_0004737c
obo:TXPO_0004677c
obo:TXPO_0004642c
obo:TXPO_0001889c
obo:TXPO_0004248c
obo:TXPO_0004714c
obo:TXPO_0001971c
obo:TXPO_0004710c
obo:TXPO_0004706c
obo:TXPO_0004297c
obo:TXPO_0004853c
obo:TXPO_0001706c
obo:TXPO_0002380c
obo:TXPO_0004240c
obo:TXPO_0003959c
obo:TXPO_0004719c
obo:TXPO_0003935c
obo:TXPO_0004785c
obo:TXPO_0001636c
obo:TXPO_0004762c

changing directionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000022
Super-classes obo:TXPO_0000415c
Restrictions obo:TXPO_0000531op some obo:PATO_0000039c
Sub-classes obo:TXPO_0003122c

molecular activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000023
Super-classes obo:TXPO_0000401c
Restrictions obo:RO_0002234op some (obo:CHEBI_23367c and ub744bL41540C17c)
Sub-classes obo:TXPO_0004754c
obo:TXPO_0002464c
obo:TXPO_0001219c
obo:TXPO_0001758c
obo:TXPO_0003095c
obo:TXPO_0002454c
obo:TXPO_0003106c
obo:TXPO_0000583c
obo:TXPO_0000124c
obo:TXPO_0004446c
obo:TXPO_0000357c
obo:TXPO_0005021c
obo:TXPO_0000408c
obo:TXPO_0000409c
obo:TXPO_0000405c
obo:TXPO_0004612c
obo:TXPO_0003108c
obo:TXPO_0000407c
obo:TXPO_0004740c
obo:TXPO_0000031c
obo:TXPO_0001313c
obo:TXPO_0000705c
obo:TXPO_0004558c
obo:TXPO_0000729c
obo:TXPO_0002872c
obo:TXPO_0002825c
obo:TXPO_0002949c
obo:TXPO_0004760c
obo:TXPO_0001309c
obo:TXPO_0004326c
obo:TXPO_0002828c
obo:TXPO_0002780c

changing bondc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000024
Super-classes obo:TXPO_0000261c
Sub-classes obo:TXPO_0000025c

changing disulfide bondc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000025
Super-classes obo:TXPO_0000024c
Sub-classes obo:TXPO_0000037c

integrated signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000027
Description
  1. signal detection (acceptance), 2. signal transduction, 3. gene regulation (genetic information conversion process), 4. celllular process execution This entity covers from 1, 2, and 3.
Super-classes obo:NCIT_C54214c
Restrictions obo:TXPO_0002524op some obo:TXPO_0000609c
Sub-classes obo:TXPO_0002548c
obo:TXPO_0002563c
obo:GO_0007249c
obo:GO_0008286c
obo:TXPO_0002490c
obo:TXPO_0002489c
obo:TXPO_0000067c

eosinophilic granular degeneration [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000028
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0000174c
obo:BFO_0000051op some obo:TXPO_0000179c
obo:TXPO_0000004op some obo:TXPO_0000105c
obo:BFO_0000051op some obo:TXPO_0000109c
obo:BFO_0000051op some obo:TXPO_0000105c
obo:BFO_0000051op some obo:TXPO_0000746c
obo:BFO_0000051op some obo:TXPO_0000110c
obo:BFO_0000051op some obo:TXPO_0001005c
obo:BFO_0000051op some obo:TXPO_0000176c
obo:BFO_0000051op some obo:TXPO_0002158c
obo:BFO_0000051op some obo:TXPO_0000118c
Sub-classes obo:TXPO_0003234c
obo:TXPO_0002023c

hepatic fibrosis dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000029
Super-classes obo:TXPO_0003749c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
Sub-classes obo:TXPO_0003762c
obo:TXPO_0003760c

dysfunction of calcium transport [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000030
Super-classes obo:TXPO_0001727c
obo:TXPO_0000167c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000355c

CREB3L3 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000031
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0003080c

bosentan [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000032
Description

Rifampicin, bosentan, and troglitazone directly inhibit bile salt export pump (BSEP).
Super-classes obo:TXPO_0000749c
obo:CHEBI_51450c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

ACOX familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000033
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_1000027c

cholestasis dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000034
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
Sub-classes obo:TXPO_0000264c
obo:TXPO_0002679c
obo:TXPO_0000066c
obo:TXPO_0002627c
obo:TXPO_0002674c
obo:TXPO_0003133c
obo:TXPO_0001994c
obo:TXPO_0000084c
obo:TXPO_0002659c
obo:TXPO_0002658c
obo:TXPO_0000545c
obo:TXPO_0002652c
obo:TXPO_0002676c
obo:TXPO_0002669c
obo:TXPO_0002630c
obo:TXPO_0002638c
obo:TXPO_0002664c
obo:TXPO_0002641c
obo:TXPO_0000086c
obo:TXPO_0000268c
obo:TXPO_0003136c
obo:TXPO_0002657c
obo:TXPO_0003154c
obo:TXPO_0000089c
obo:TXPO_0000265c
obo:TXPO_0002675c
obo:TXPO_0002632c
obo:TXPO_0002626c
obo:TXPO_0002681c
obo:TXPO_0000639c
obo:TXPO_0002660c
obo:TXPO_0003135c
obo:TXPO_0003212c
obo:TXPO_0003137c
obo:TXPO_0002646c
obo:TXPO_0002678c
obo:TXPO_0002670c
obo:TXPO_0002654c
obo:TXPO_0003134c
obo:TXPO_0003312c
obo:TXPO_0002614c
obo:TXPO_0000041c
obo:TXPO_0001759c
obo:TXPO_0002649c
obo:TXPO_0003211c
obo:TXPO_0002666c
obo:TXPO_0002637c
obo:TXPO_0002662c
obo:TXPO_0002645c
obo:TXPO_0002644c
obo:TXPO_0000350c
obo:TXPO_0003147c
obo:TXPO_0002663c

hypofunction of extracellular matrix disassemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000035
Super-classes obo:TXPO_0000940c

tranport regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000036
Super-classes obo:TXPO_0003230c
Sub-classes obo:TXPO_0001867c
obo:TXPO_0000056c

changing disulfide bond [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000037
Super-classes obo:TXPO_0000025c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002233op some obo:TXPO_0001980c

toxic agentc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000038
Super-classes obo:CHEBI_52209c
Sub-classes obo:CHEBI_50912c
obo:CHEBI_50908c
obo:CHEBI_50902c
obo:TXPO_0001373c

increasing weightc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000040
Super-classes obo:TXPO_0000589c
Restrictions obo:BFO_0000051op some obo:TXPO_0000139c
obo:BFO_0000051op some obo:TXPO_0000093c
Sub-classes obo:TXPO_0000054c
obo:TXPO_0001286c

inreasing blood ALP concentration [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000041
Super-classes obo:TXPO_0001346c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

mitochondrial dysfunction [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000042
Super-classes obo:TXPO_0001730c
obo:TXPO_0002361c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c
obo:TXPO_0000069op some obo:TXPO_0000605c

ATF6 (golgi apparatus) (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000044
Super-classes obo:TXPO_0000879c
Restrictions obo:TXPO_0000043op some obo:GO_0005794c
Sub-classes obo:TXPO_0002902c
obo:TXPO_0002958c
obo:TXPO_0002901c
obo:TXPO_0002910c

hypofunction of bile acid and bile salt transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000045
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:GO_0015721c

cleavage of ATF6-alpha by S2Pc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000046
Super-classes obo:TXPO_0000333c
Restrictions obo:RO_0002233op some obo:IMR_0000831c
Sub-classes obo:TXPO_0000349c

NRF2 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000047
Super-classes obo:TXPO_0000871c
obo:TXPO_0002527c
Sub-classes obo:TXPO_0002745c

cleavage of ATF6-alpha by S1Pc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000048
Super-classes obo:TXPO_0000333c
Restrictions obo:RO_0002233op some obo:IMR_0000831c
Sub-classes obo:TXPO_0000049c

cleavage of ATF6-alpha by S1P [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000049
Super-classes obo:TXPO_0003736c
obo:TXPO_0000048c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000349c
obo:TXPO_0000774op only obo:TXPO_0002528c

inflammatory cytokine gene expression [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000050
Super-classes obo:TXPO_0001720c
obo:TXPO_0002266c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

ChREBP activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000051
Super-classes obo:TXPO_0000124c
Sub-classes obo:TXPO_0001121c

cationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000052
Super-classes obo:CHEBI_24870c
Sub-classes obo:CHEBI_39124c

Translocation of ATF6 from the cytosol to the nucleusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000053
Super-classes obo:GO_0051169c
Restrictions obo:RO_0002339op some obo:GO_0005634c
obo:RO_0002338op some obo:GO_0005829c
Sub-classes obo:TXPO_0000055c

increasing liver weightc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000054
Super-classes obo:TXPO_0000040c
Sub-classes obo:TXPO_0003271c
obo:TXPO_0000841c
obo:TXPO_0000096c
obo:TXPO_0000972c

Translocation of ATF6 from the cytosol to the nucleus [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000055
Super-classes obo:TXPO_0003736c
obo:TXPO_0000053c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002843c

bile acid transport regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000056
Super-classes obo:TXPO_0000036c
Restrictions obo:RO_0002596op some obo:GO_0015721c
Sub-classes obo:TXPO_0000082c
obo:TXPO_0002712c

transmembrane signaling receptor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000057
Super-classes obo:TXPO_0002463c
Sub-classes obo:TXPO_0003331c
obo:TXPO_0000058c
obo:TXPO_0003561c

death receptor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000058
Description

related molecular function GO:0005035
Super-classes obo:TXPO_0000057c

lysosome damagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000059
Super-classes obo:TXPO_0000070c
Sub-classes obo:TXPO_0002094c

ground glass appearance [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000060
Description

Monochromatic eosinophilic change across the whole or most of the hepatocyte. It is often observed as a changing response to the hepatic metabolism enzyme inducer such as phenobarbital. In electron microscopy, it is regarded as prominent proliferation of smooth endoplasmic reticulum, dispersion of rough endoplasmic reticulum, with decrease of stored glycogen.
Super-classes obo:TXPO_0000662c
Sub-classes obo:TXPO_0003522c

PERK signaling to eIF2a [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000061
Super-classes obo:TXPO_0001717c
obo:TXPO_0002449c
Restrictions obo:BFO_0000051op some obo:TXPO_0002514c
obo:TXPO_0000069op some obo:TXPO_0002762c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0002162c
obo:BFO_0000051op some obo:TXPO_0002506c

PERK signaling to eIF2a [PERK - eIF2A pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000062
Super-classes obo:TXPO_0000454c
Restrictions obo:BFO_0000051op some obo:TXPO_0000696c
Sub-classes obo:TXPO_0002449c

PERK dimerization [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000063
Super-classes obo:TXPO_0000713c
Restrictions obo:RO_0000057op some obo:TXPO_0002884c
obo:TXPO_0000069op some obo:TXPO_0000388c
obo:TXPO_0000774op only obo:TXPO_0002528c

unfolded protein rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000064
Super-classes obo:CHEBI_52209c

cellular tissuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000065
Super-classes obo:BFO_0000027c
Sub-classes obo:GO_0031012c
obo:GO_0005737c
obo:GO_0005829c
obo:TXPO_0004047c
obo:UBERON_0000479c

changing cytoskeleton [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000066
Super-classes obo:TXPO_0000034c
obo:TXPO_0000238c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

PERK signaling (integrated pathway)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000067
Super-classes obo:TXPO_0000027c
Sub-classes obo:TXPO_0002735c
obo:TXPO_0000701c
obo:TXPO_0002793c

negative regulation of formation of cytoplasmic translation initiation complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000068
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0001732c
Sub-classes obo:TXPO_0000416c
obo:TXPO_0002988c

organelle damagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000070
Super-classes obo:TXPO_0000222c
Sub-classes obo:TXPO_0000059c

sphingolipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000071
Super-classes obo:GO_0016042c
Restrictions obo:RO_0002233op some obo:CHEBI_26739c
Sub-classes obo:GO_0046514c
obo:TXPO_0001465c

insulin deficiencyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000072
Super-classes obo:TXPO_0000482c
Sub-classes obo:TXPO_0003289c
obo:TXPO_0003497c
obo:TXPO_0000074c

natural killer cell activation [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000073
Super-classes obo:GO_0030101c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

insulin deficiency [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000074
Super-classes obo:TXPO_0000072c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001245c
obo:TXPO_0000774op only obo:TXPO_0002528c

increasing GDF15 level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000075
Super-classes obo:TXPO_0004569c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004222c
obo:RO_0000057op some obo:TXPO_0003613c
obo:TXPO_0000774op only obo:TXPO_0001986c

ITGB3 (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000077
Super-classes obo:TXPO_0003817c
obo:TXPO_0001135c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000003690c

SULT1C2(predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000078
Super-classes obo:TXPO_0003832c
obo:TXPO_0001135c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000006819c

ECM2 - tumor progression marker (predicted)(human) [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000079
Description

predicted gene by Support Vector Machine (SVM) using human primary hepatocyte
Super-classes obo:TXPO_0000661c
obo:TXPO_0000665c
Restrictions obo:RO_0000087op some obo:TXPO_0000080c
obo:RO_0000086op some obo:TXPO_0000657c

tumor progression marker rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000080
Super-classes obo:TXPO_0001225c

clomipramine_CAD [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000081
Super-classes obo:TXPO_0001849c
obo:CHEBI_47780c
Restrictions obo:RO_0000087op some obo:TXPO_0001426c

bile acid transport inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000082
Super-classes obo:TXPO_0000056c
Restrictions obo:RO_0002599op some obo:GO_0015721c
Sub-classes obo:TXPO_0001866c

bile pigment depositionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000083
Super-classes obo:GO_0043473c
Sub-classes obo:TXPO_0003150c
obo:TXPO_0001906c

changing membrane fluidity [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000084
Super-classes obo:TXPO_0000034c
obo:TXPO_0000412c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

hypofunction of transmembrane transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000085
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:GO_0006810c
Sub-classes obo:TXPO_0000086c

hypofunction of transmembrane transport [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000086
Super-classes obo:TXPO_0000034c
obo:TXPO_0000085c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000716op some obo:GO_0006810c

Dnajb9 apoptosis inhibitor (rat)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000087
Super-classes obo:TXPO_1000114c
obo:TXPO_0000753c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c

increasing acetyl CoAc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000088
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0001131c
obo:TXPO_0004127c
obo:TXPO_0001305c

apoptotic process [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000089
Super-classes obo:TXPO_0000034c
obo:GO_0006915c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003312c
obo:TXPO_0000774op only obo:TXPO_0001277c

meloxicam - apotosis inducing factor [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000090
Super-classes obo:TXPO_0001982c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c

endoplasmic reticulum proliferation in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000091
Super-classes obo:TXPO_0003303c
Restrictions obo:RO_0002234op some (obo:GO_0005783c and ub744bL42284C17c)
Sub-classes obo:TXPO_0000092c
obo:TXPO_0001230c

increasing number of hepatocellular endoplasmic reticulum This entity is a specific course-dependent process. This process can constitute the course of Ground glass appearance.c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000092
Super-classes obo:TXPO_0000091c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

increasing number of objectsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000093
Super-classes obo:TXPO_0000387c
Restrictions obo:TXPO_0000531op some obo:PATO_0002002c
obo:RO_0002234op some (obo:BFO_0000040c and ub744bL42314C17c)
Sub-classes obo:GO_0006260c
obo:TXPO_0001296c
obo:GO_0008283c
obo:TXPO_0001412c
obo:TXPO_0000108c
obo:TXPO_0000341c
obo:TXPO_0002139c
obo:TXPO_0002531c
obo:TXPO_0000347c

maintaining permeabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000094
Super-classes obo:TXPO_0002704c
Sub-classes obo:TXPO_0000133c

hyperfunction of fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000095
Super-classes obo:TXPO_0000099c
Sub-classes obo:TXPO_0002344c
obo:TXPO_0000177c

increasing liver weight [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000096
Super-classes obo:TXPO_0001729c
obo:TXPO_0000054c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001729c

fatty acid omega-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000097
Super-classes obo:GO_0019395c

hyperfunction of lipid oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000098
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0034440c
Sub-classes obo:TXPO_0000099c

hyperfunction of fatty acid oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000099
Super-classes obo:TXPO_0000098c
Sub-classes obo:TXPO_0000095c

hyperfunction of lipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000100
Super-classes obo:TXPO_0002349c
Restrictions obo:TXPO_0001502op some obo:GO_0016042c

hyperfunction of cerramide phagocytosis by Kupffer cells or macrophges [Phospholipidosis-sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000101
Super-classes obo:TXPO_0004151c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004160c
obo:RO_0000057op some obo:CL_0000091c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:RO_0000057op some obo:CL_0000235c

increasing demand for response to oxidative stressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000102
Super-classes obo:TXPO_0000361c
Sub-classes obo:TXPO_0000103c
obo:TXPO_0000455c
obo:TXPO_0000947c
obo:TXPO_0000517c
obo:TXPO_0000574c
obo:TXPO_0004543c
obo:TXPO_0003510c
obo:TXPO_0004373c
obo:TXPO_0003174c
obo:TXPO_0002301c

increasing demand for response to oxidative stress [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000103
Super-classes obo:TXPO_0000102c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003219c
obo:TXPO_0000774op only obo:TXPO_0000028c

peroxisomal proliferation in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000104
Super-classes obo:TXPO_0003303c
Restrictions obo:RO_0002234op some (obo:GO_0005777c and ub744bL42440C17c)
Sub-classes obo:TXPO_0003300c
obo:TXPO_0000105c

peroxisomal proliferation in hepatocyte [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000105
Description

Humans do not respond with hepatocellular and peroxisomal proliferation to fibrates and express PPARalpha at low levels and often in nonfunctional forms.

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
Super-classes ()
obo:TXPO_0000104c
obo:TXPO_0001729c
Restrictions obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:RO_0000057op some obo:TXPO_0001045c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000165c
obo:TXPO_0001873op some obo:TXPO_0003523c
Sub-classes obo:TXPO_0001016c
obo:TXPO_0001025c
obo:TXPO_0001023c

hyperfunction of phenobarbital metabolism [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000106
Super-classes obo:TXPO_0001728c
obo:TXPO_0000443c
Restrictions obo:BFO_0000051op some obo:TXPO_0003864c
obo:TXPO_0000069op some obo:TXPO_0003860c
obo:BFO_0000051op some obo:TXPO_0001663c
obo:TXPO_0000774op only obo:TXPO_0001432c

peroxisomal Acox biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000107
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0000110c

organelle proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000108
Super-classes obo:TXPO_0000093c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
obo:RO_0002234op some (obo:GO_0043226c and ub744bL42529C17c)
Sub-classes obo:TXPO_0003303c

long-chain fatty acid import into peroxisome [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000109
Super-classes obo:GO_0015910c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000179c
obo:TXPO_0000774op only obo:TXPO_0000028c

peroxisomal Acox biosynthetic process [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000110
Super-classes obo:TXPO_0000107c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000176c
obo:RO_0000057op some obo:TXPO_0003249c
obo:RO_0000057op some obo:TXPO_0001060c
obo:RO_0000057op some obo:TXPO_0003248c
obo:TXPO_0000774op only obo:TXPO_0000028c

molecule transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000111
Super-classes obo:GO_0006810c
Sub-classes obo:TXPO_0001195c
obo:TXPO_0002225c
obo:GO_0006869c
obo:TXPO_0000002c
obo:GO_0008643c
obo:GO_0015871c
obo:GO_0006811c
obo:GO_0030970c

fatty acid alpha-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000112
Super-classes obo:GO_0019395c

controllingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000113
Super-classes obo:TXPO_0002541c
Restrictions obo:RO_0002211op some obo:BFO_0000015c
Sub-classes obo:GO_0050776c
obo:GO_0051726c
obo:GO_0010506c
obo:GO_0010941c
obo:GO_0006417c
obo:TXPO_0002665c
obo:GO_0042981c
obo:TXPO_0000369c
obo:TXPO_0001223c
obo:GO_0006355c
obo:GO_0023051c
obo:GO_0043467c
obo:GO_0010468c
obo:GO_0045595c
obo:GO_0019222c
obo:TXPO_0003636c

phosphoethanolamine catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000114
Super-classes obo:GO_0009056c
Restrictions obo:RO_0002233op some obo:CHEBI_36711c

negative regulation of decomposingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000115
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0000343c
Sub-classes obo:GO_0042177c
obo:TXPO_0000126c
obo:TXPO_0001972c
obo:GO_0045820c
obo:TXPO_0001256c

regulation of lipid metabolic process [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000116
Super-classes obo:GO_0019216c
obo:TXPO_0001729c
Restrictions obo:TXPO_0001868op some obo:TXPO_0004006c
obo:BFO_0000051op some obo:TXPO_0000118c
obo:TXPO_0000774op only obo:TXPO_0000028c

drug metabolism phase I by Cytochrome P450 [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000117
Super-classes obo:TXPO_0001559c
obo:TXPO_0000889c
Restrictions obo:BFO_0000066op some obo:GO_0005790c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0002233op some obo:TXPO_0001922c
obo:RO_0002234op some obo:TXPO_0000974c

regulation of beta oxidation related gene expression [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000118
Super-classes obo:TXPO_0001729c
obo:TXPO_0000119c
Restrictions obo:RO_0000057op some obo:TXPO_0001058c
obo:RO_0000057op some obo:TXPO_0001069c
obo:RO_0000057op some obo:TXPO_0001055c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000146c
obo:RO_0000057op some obo:TXPO_0002017c
obo:TXPO_0000069op some obo:TXPO_0000174c
obo:RO_0000057op some obo:TXPO_0001046c
obo:RO_0000057op some obo:TXPO_0001051c
obo:BFO_0000051op some obo:TXPO_0000128c
obo:RO_0000057op some obo:TXPO_0001053c
obo:RO_0000057op some obo:TXPO_0001067c
obo:RO_0000057op some obo:TXPO_0001068c
obo:RO_0000057op some obo:TXPO_0001057c
Sub-classes obo:TXPO_0002448c

regulation of beta oxidation related gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000119
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0002448c
obo:TXPO_0000118c
obo:TXPO_0000129c

PLA1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000120
Super-classes obo:TXPO_0000635c
obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0000819op some obo:OGG_3000025833c
Sub-classes obo:TXPO_0001803c

fibrate [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000121
Super-classes obo:TXPO_0002383c
obo:TXPO_1000442c
Sub-classes obo:TXPO_0001897c
obo:TXPO_0001895c

WY14643 [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000122
Super-classes obo:TXPO_0002383c
obo:CHEBI_32509c

receiving abnormal protein signal by PERK [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000123
Super-classes obo:TXPO_0002741c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000012op some obo:TXPO_0000463c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002625c
obo:TXPO_0000069op some obo:TXPO_0000061c

transcription factor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000124
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0001213c
obo:TXPO_0000051c
obo:TXPO_0001114c
obo:TXPO_0000158c
obo:TXPO_0002782c
obo:TXPO_0001283c
obo:TXPO_0001112c
obo:TXPO_0001904c
obo:TXPO_0000723c

PPARalpha activation (severe) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000125
Super-classes obo:TXPO_0001005c
Restrictions obo:RO_0000057op some obo:TXPO_0000121c
obo:TXPO_0000069op some obo:TXPO_0000190c
obo:TXPO_0000069op some obo:TXPO_0002047c
obo:TXPO_0000069op some obo:TXPO_0000182c
obo:TXPO_0000069op some obo:TXPO_0000116c
obo:TXPO_0000069op some obo:TXPO_0000196c
obo:RO_0000057op some obo:TXPO_0001048c
obo:RO_0000057op some obo:TXPO_0001328c
obo:TXPO_0000069op some obo:TXPO_0000127c
obo:TXPO_0000069op some obo:TXPO_0002448c
obo:RO_0000057op some obo:TXPO_0000122c
obo:TXPO_0000069op some obo:TXPO_0000184c
obo:TXPO_0000069op some obo:TXPO_0001025c
obo:TXPO_0000069op some obo:TXPO_0000149c
obo:TXPO_0000774op only obo:TXPO_0000028c

negative regulation of mRNA catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000126
Super-classes obo:TXPO_0000115c
Restrictions obo:RO_0002212op some obo:GO_0006402c
Sub-classes obo:TXPO_0003794c

autophagy [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000127
Super-classes obo:GO_0006914c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000187c
obo:TXPO_0000069op some obo:TXPO_0003207c
obo:BFO_0000051op some obo:TXPO_0003219c

regulation of mitochondrial beta oxidation related gene [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000128
Super-classes obo:TXPO_0000129c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000146c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0001058c

regulation of mitochondrial beta oxidation related genec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000129
Super-classes obo:TXPO_0000119c
Sub-classes obo:TXPO_0000128c

negative regulation of lipid storage [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000130
Super-classes obo:GO_0010888c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

lipid transport to mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000131
Super-classes obo:GO_0006869c
Restrictions obo:RO_0002339op some obo:GO_0005739c

unfolded protein [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000132
Super-classes obo:TXPO_0002106c

maintaining membrane permeabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000133
Super-classes obo:TXPO_0000094c
Sub-classes obo:TXPO_0000607c

biological structure formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000134
Super-classes obo:TXPO_0000168c
Sub-classes obo:TXPO_0000612c
obo:TXPO_0001358c
obo:TXPO_0003141c
obo:NCIT_C18121c
obo:TXPO_0004603c
obo:TXPO_0000322c
obo:TXPO_0001363c
obo:TXPO_0001364c
obo:GO_0071840c
obo:TXPO_0005046c

G6PD (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000135
Super-classes obo:TXPO_0002045c
obo:TXPO_1000158c
Restrictions obo:RO_0000087op some obo:TXPO_0002402c

tumorigenesis [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000136
Super-classes obo:NCIT_C18121c
obo:TXPO_0001729c
Restrictions obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0000028c

GADD45A (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000137
Super-classes obo:TXPO_0002045c
obo:TXPO_1000174c
Restrictions obo:TXPO_0002260op some obo:IMR_0000559c

increasing sizec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000138
Super-classes obo:TXPO_0002705c
Sub-classes obo:TXPO_0001812c
obo:GO_0040007c
obo:TXPO_0001360c
obo:TXPO_0000253c
obo:TXPO_0000139c

increasing volumec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000139
Super-classes obo:TXPO_0000417c
obo:TXPO_0000138c
Restrictions obo:RO_0002233op some obo:BFO_0000040c
obo:TXPO_0000531op some obo:PATO_0000595c
obo:RO_0002234op some (obo:BFO_0000040c and ub744bL43046C17c and obo:BFO_0000040c and ub744bL43033C17c)
obo:RO_0002234op some (obo:BFO_0000040c and ub744bL43046C17c and obo:BFO_0000040c and ub744bL43033C17c)
Sub-classes obo:TXPO_0000616c
obo:TXPO_0003741c
obo:TXPO_0002717c
obo:TXPO_0000142c

increasing areac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000140
Super-classes obo:TXPO_0000544c
Restrictions obo:TXPO_0000531op some obo:PATO_0002057c
Sub-classes obo:TXPO_0001229c

increasing lengthc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000141
Super-classes obo:TXPO_0000552c
Restrictions obo:TXPO_0000531op some obo:PATO_0000573c

increasing cell volumec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000142
Super-classes obo:TXPO_0000139c
Restrictions obo:RO_0002234op some (obo:CL_0000000c and ub744bL43120C17c and obo:CL_0000000c and ub744bL43107C17c)
obo:RO_0002234op some (obo:CL_0000000c and ub744bL43120C17c and obo:CL_0000000c and ub744bL43107C17c)
obo:BFO_0000066op some obo:CL_0000000c
obo:RO_0002233op some obo:CL_0000000c
Sub-classes obo:TXPO_0002389c
obo:TXPO_0000545c
obo:TXPO_0000164c

increasing volume of mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000143
Super-classes obo:TXPO_0003741c
Restrictions obo:RO_0002234op some (obo:GO_0005739c and ub744bL43152C17c and obo:GO_0005739c and ub744bL43165C17c)
obo:RO_0002234op some (obo:GO_0005739c and ub744bL43152C17c and obo:GO_0005739c and ub744bL43165C17c)
obo:RO_0002233op some obo:GO_0005739c
Sub-classes obo:TXPO_0001879c
obo:TXPO_0004128c

increasing energyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000144
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003593c
obo:TXPO_0004137c
obo:TXPO_0000151c
obo:TXPO_0003592c

function-related processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000145
Description

This tree is based on a functional concept ontology (Kitamura 2002).
Super-classes obo:TXPO_0000271c
Sub-classes obo:TXPO_0000378c
obo:TXPO_0000434c
obo:TXPO_0000600c
In range of obo:TXPO_0003399op

hyperfunction of mitochondrial fatty acid beta-oxidation [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000146
Super-classes obo:TXPO_0002344c
obo:TXPO_0001729c
Restrictions obo:RO_0000057op some obo:TXPO_0001058c
obo:TXPO_0000069op some obo:TXPO_0000151c
obo:TXPO_0000069op some obo:TXPO_0000103c
obo:RO_0000057op some obo:TXPO_0001050c
obo:RO_0000057op some obo:TXPO_0001070c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0001066c
obo:RO_0000057op some obo:TXPO_0001064c

refolding-unfolding imbalance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000147
Super-classes obo:TXPO_0002459c
obo:TXPO_0001717c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0001733op some obo:TXPO_0003992c
obo:TXPO_0000069op some obo:TXPO_0001977c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002460c
obo:TXPO_0002458c

massive hepatic necrosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000148
Super-classes obo:TXPO_0000520c

regulation of carbohydrate metabolic process [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000149
Super-classes obo:GO_0006109c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000153c
obo:RO_0000057op some obo:TXPO_0003409c

GADD34 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000150
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023645c
Sub-classes obo:TXPO_0002934c

increasing energy [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000151
Super-classes obo:TXPO_0000144c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0001047c

TIMP1 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000152
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0000224c

glycolytic process [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000153
Super-classes obo:GO_0006096c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000151c

electron transfer moeculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000154
Description

related molecular function GO:0009055
Super-classes obo:TXPO_0003638c

hematopoietic factorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000155
Super-classes obo:TXPO_0000622c

inflammatory cell infiltration [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000156
Super-classes obo:TXPO_0000540c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001488c
obo:RO_0000057op some obo:TXPO_0004072c
obo:BFO_0000051op some obo:TXPO_0004113c
obo:TXPO_0000774op only obo:TXPO_0002215c

decreasing sensitivityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000157
Super-classes obo:TXPO_0000015c
Sub-classes obo:TXPO_0002189c
obo:TXPO_0004958c

nuclear receptor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000158
Super-classes obo:TXPO_0000124c
Sub-classes obo:TXPO_0003143c
obo:TXPO_0000411c
obo:TXPO_0001209c
obo:TXPO_0003855c
obo:TXPO_0001210c
obo:TXPO_0000013c
obo:TXPO_0001214c

PPARA (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000159
Super-classes obo:IMR_0000089c
Sub-classes obo:TXPO_0001632c
obo:TXPO_0001328c
obo:TXPO_0004061c
obo:TXPO_0004766c
obo:TXPO_0003243c
obo:TXPO_0005126c
obo:TXPO_0002501c
obo:TXPO_0004767c
obo:TXPO_0005125c

ARc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000160
Super-classes obo:TXPO_0001509c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c

PGR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000161
Super-classes obo:TXPO_0001509c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c

PPARGc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000162
Super-classes obo:IMR_0000089c

release of phospholipid from lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000163
Super-classes obo:TXPO_0002588c
Restrictions obo:BFO_0000066op some obo:GO_0005764c

increasing hepatocellular volumec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000164
Super-classes obo:TXPO_0000142c
Restrictions obo:RO_0002234op some (obo:CL_0000182c and ub744bL43455C17c and obo:CL_0000182c and ub744bL43442C17c)
obo:RO_0002233op some obo:CL_0000182c
obo:RO_0002234op some (obo:CL_0000182c and ub744bL43455C17c and obo:CL_0000182c and ub744bL43442C17c)
obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0003480c
obo:TXPO_0003297c
obo:TXPO_0002536c
obo:TXPO_0000165c
obo:TXPO_0000969c
obo:TXPO_0000921c
obo:TXPO_0000265c

increasing hepatocellular volume [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000165
Super-classes obo:TXPO_0000164c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
Sub-classes obo:TXPO_0002025c
obo:TXPO_0002029c
obo:TXPO_0002027c

addition of foreign substancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000166
Super-classes obo:TXPO_0000468c
Sub-classes obo:TXPO_0003754c

dysfunction of calcium transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000167
Super-classes obo:TXPO_0000438c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000366c
Sub-classes obo:TXPO_0000030c

having extra partsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000168
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0004046c
obo:TXPO_0000134c

accumulation of xenobioticsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000169
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some (obo:BFO_0000040c and ub744bL43517C17c)
Sub-classes obo:TXPO_0002325c
obo:TXPO_0001242c
obo:TXPO_0002212c
obo:TXPO_0001235c
obo:TXPO_0003187c
obo:TXPO_0001694c

accumulation of compound in ER [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000170
Super-classes obo:TXPO_0001717c
obo:TXPO_0002212c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002161c
obo:RO_0000057op some obo:TXPO_0001980c
obo:RO_0000057op some obo:TXPO_0001962c
obo:TXPO_0000069op some obo:TXPO_0000037c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0001965c

ligasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000171
Description

related molecular function GO:0016874
Super-classes obo:TXPO_0003660c
Sub-classes obo:TXPO_0001937c
obo:TXPO_0000266c

ultimate toxicantc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000172
Super-classes obo:CHEBI_64909c

drug metabolism phase Ic # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000173
Description

Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemically reactive would facilitate their excretion but also increases their chance of reacting with cellular macromolecules (e.g. proteins, DNA). There is a fine balance between producing a more reactive metabolite and conjugation reactions. There are two groups of enzymes in phase 1 - oxidoreductases and hydrolases. Oxidoreductases introduce an oxygen atom into or remove electrons from their substrates. The major oxidoreductase enzyme system is called the P450 monooxygenases. Other systems include flavin-containing monooxygenases (FMO), cyclooxygenases (COX) and monoamine oxidases (MAO). Hydrolases hydrolyse esters, amides, epoxides and glucuronides.
Super-classes obo:GO_0017144c
Sub-classes obo:TXPO_0001597c
obo:TXPO_0001559c

peroxisome fatty acid beta oxidation gene expression [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000174
Super-classes obo:TXPO_0001729c
obo:TXPO_0000175c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000110c
obo:RO_0000057op some obo:TXPO_0001046c
obo:TXPO_0000069op some obo:TXPO_0000176c
obo:BFO_0000051op some obo:TXPO_0000110c
obo:RO_0000057op some obo:TXPO_0000846c
obo:RO_0000057op some obo:TXPO_0001057c
obo:RO_0000057op some obo:TXPO_0001069c
obo:TXPO_0000774op only obo:TXPO_0000028c
Sub-classes obo:TXPO_0003060c

peroxisome fatty acid beta oxidation gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000175
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0000174c
obo:TXPO_0003060c

hyperfunction of peroxisomal fatty acid beta-oxidation [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000176
Super-classes obo:TXPO_0000177c
obo:TXPO_0001729c
Restrictions obo:RO_0000057op some obo:TXPO_0001074c
obo:TXPO_0000069op some obo:TXPO_0002134c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0001061c
obo:RO_0000057op some obo:TXPO_0003250c
obo:RO_0000057op some obo:TXPO_0001060c
obo:BFO_0000066op some obo:GO_0005777c
obo:RO_0000057op some obo:TXPO_0003246c
Sub-classes obo:TXPO_0002451c

hyperfunction of peroxisomal fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000177
Super-classes obo:TXPO_0000095c
Sub-classes obo:TXPO_0002451c
obo:TXPO_0000176c
obo:TXPO_0003180c

increasing demand for peroxisomal fatty acid beta oxidation [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000179
Super-classes obo:TXPO_0000180c
obo:TXPO_0001729c
Restrictions obo:BFO_0000066op some obo:GO_0005777c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0002158c

increasing demand for peroxisomal fatty acid beta oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000180
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0000179c

accumulation of drug in hepatocyte [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000181
Super-classes obo:TXPO_0001728c
obo:TXPO_0002325c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of lipid biosynthetic process [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000182
Super-classes obo:TXPO_0001729c
obo:GO_0051055c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0001868op some obo:TXPO_0001328c

regulation of cell cycle related gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000183
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0000184c
obo:TXPO_0002987c

regulation of cell cycle related gene expression [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000184
Super-classes obo:TXPO_0000183c
obo:TXPO_0001729c
Restrictions obo:RO_0000057op some obo:TXPO_0003238c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0003242c
obo:TXPO_0000069op some obo:TXPO_0003231c
obo:TXPO_0000069op some obo:TXPO_0002100c
obo:TXPO_0001868op some obo:TXPO_0003244c

biochemical degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000185
Super-classes obo:TXPO_0000343c
Sub-classes obo:NCIT_C16702c
obo:GO_0009056c

microtubule cytoskeletal proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000186
Super-classes obo:TXPO_0003689c

lipid catabolic process [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000187
Super-classes obo:GO_0016042c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

SPON2(mouse) - obesity inhibitor[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000188
Super-classes obo:TXPO_0003834c
obo:TXPO_0003278c
Restrictions obo:RO_0000087op some obo:TXPO_0000189c
obo:TXPO_0000819op some obo:OGG_3000010417c
obo:RO_0000087op some obo:TXPO_0003351c

inhibitor of obesityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000189
Super-classes obo:TXPO_0003230c

negative regulation of cytokine gene expression [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000190
Super-classes obo:TXPO_0003218c
obo:TXPO_0001729c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001328c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0003207c

inflammatory cytokine gene expression [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000191
Description

PPARα inhibits NF-κB to express inflammatory cytokines (TNF-α, IL-1b, etc).
Super-classes obo:TXPO_0002266c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

inflammatory responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000192
Super-classes obo:TXPO_0002590c
Sub-classes obo:TXPO_0002142c
obo:TXPO_0001488c
obo:TXPO_0003830c
obo:TXPO_0002670c
obo:TXPO_0004271c
obo:TXPO_0000815c
obo:TXPO_0000760c
obo:TXPO_0003620c
obo:TXPO_0003168c
obo:TXPO_0004542c

GCLC (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000193
Description

ATP dependent
Super-classes obo:TXPO_1000163c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:TXPO_0002394c
Sub-classes obo:TXPO_0001951c

accumulation of abnormal proteins in ER [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000194
Super-classes obo:TXPO_0002187c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:GO_0005783c
Sub-classes obo:TXPO_0002470c
obo:TXPO_0001977c

regulation of gene expression by miRNAc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000195
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0000196c

regulation of gene expression by miRNA [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000196
Super-classes obo:TXPO_0001729c
obo:TXPO_0000195c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000198c
obo:TXPO_0000774op only obo:TXPO_0000028c

oncogene mRNA stabilizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000197
Super-classes obo:TXPO_0003733c
Sub-classes obo:TXPO_0000198c

oncogene mRNA stabilization [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000198
Super-classes obo:TXPO_0001729c
obo:TXPO_0000197c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000136c
obo:TXPO_0000774op only obo:TXPO_0000028c

liver cancer dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000199
Description

under construction
Super-classes obo:TXPO_0001731c
Sub-classes obo:TXPO_0000837c
obo:TXPO_0004455c

phospholipid transport from lysosome into cytosol [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000200
Super-classes obo:TXPO_0001716c
obo:TXPO_0003388c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

oxygen radicalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000201
Super-classes obo:CHEBI_26519c
Sub-classes obo:CHEBI_25935c
obo:CHEBI_18421c
obo:CHEBI_29191c

liver dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000203
Super-classes obo:TXPO_0000438c
Restrictions obo:BFO_0000051op some obo:TXPO_0001323c
obo:BFO_0000051op some obo:TXPO_0001352c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:BFO_0000051op some obo:TXPO_0001342c
obo:BFO_0000051op some obo:TXPO_0001354c
Sub-classes obo:TXPO_0003212c
obo:TXPO_0000206c
obo:TXPO_0001285c
obo:TXPO_0002373c

autophagy [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000204
Super-classes obo:TXPO_0001717c
obo:GO_0006914c
Restrictions obo:RO_0000057op some obo:TXPO_0000768c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002529c

redox-active reactant formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000205
Description

A number of xenobiotics exert a toxic effect theough their metabolites. The increased reactivity may be due to conversion into electrophiles, free radicals, nucleophiles, or redox-active reactants.

Casarett and Doull's toxicology 8th ed. Chapter 3 step1 Delibery:From the site to exposure to the target
Super-classes obo:GO_0009058c

liver dysfunction [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000206
Super-classes obo:TXPO_0000203c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:UBERON_0002107c

dysfunction of sodium transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000207
Super-classes obo:TXPO_0000438c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000368c
obo:TXPO_0000069op some obo:TXPO_0000367c

dysfunction of generating proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000208
Super-classes obo:TXPO_0000438c

free radicals formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000209
Description

A number of xenobiotics exert a toxic effect theough their metabolites. The increased reactivity may be due to conversion into electrophiles, free radicals, nucleophiles, or redox-active reactants.

Casarett and Doull's toxicology 8th ed. Chapter 3 step1 Delibery:From the site to exposure to the target
Super-classes obo:GO_0009058c

nucleophiles formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000210
Description

Nucleophiles generally are detoxificated by conjugation of a functinal group to the nucleophilic atom. Sulfonation, glucuronidation, methylation, and acetylation are common reactions.
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some (obo:BFO_0000040c and ub744bL44064C17c)

IL-2 gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000211
Super-classes obo:TXPO_0002266c

electrophiles formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000212
Description

A number of xenobiotics exert a toxic effect theough their metabolites. Electrophiles are molecules that contain an electron-deficient atom with a partial or full positive charge that can react by sharing electron pairs with electron rich atoms in nucleophiles. Electrophilic toxicants generally are detoxificated by conjugation of with the nucleophile, glutathione. This reaction can be facilitated by glutathione S-trasferases.
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some (obo:BFO_0000040c and ub744bL44093C17c)
Sub-classes obo:TXPO_0002409c
obo:TXPO_0001920c
obo:TXPO_0001882c

protein quality control for unfolded proteinsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000213
Description

GO:0006515 (protein quality control for misfolded or incompletely synthesized proteins) focuses on ERAD process. Our entity includes the process such as protein folding, ERAD and translation attenuation for unfolded protein response.
Super-classes obo:TXPO_0000474c
Sub-classes obo:TXPO_0000214c
obo:TXPO_0002539c
obo:TXPO_0002544c

protein quality control for unfolded via gene expression regulation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000214
Super-classes obo:TXPO_0000213c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002544c
obo:BFO_0000051op some obo:TXPO_0000386c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0000413c
obo:BFO_0000066op some obo:CL_0000000c

dysfunction of protein quality controlc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000215
Super-classes obo:TXPO_0000438c
Restrictions obo:BFO_0000066op some obo:CL_0000000c

increasing number of stress responsesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000216
Super-classes obo:TXPO_0000344c
Sub-classes obo:TXPO_0000745c

hepatocyte proliferation [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000217
Super-classes obo:GO_0072574c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c
obo:BFO_0000051op some obo:TXPO_0001546c
obo:BFO_0000051op some obo:TXPO_0001422c
obo:TXPO_0000069op some obo:TXPO_0003271c
obo:BFO_0000051op some obo:TXPO_0000739c

icreasing volume of endoplasmic reticulumc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000218
Super-classes obo:TXPO_0003741c
Restrictions obo:RO_0002234op some (obo:GO_0005783c and ub744bL44190C17c)

fibrosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000219
Super-classes obo:TXPO_0002590c
Restrictions obo:TXPO_0000531op some owl:Thingc
Sub-classes obo:TXPO_0000816c
obo:TXPO_0000681c

deacreasing sizec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000220
Super-classes obo:TXPO_0002705c
Sub-classes obo:TXPO_0000243c

hepatocellular atrophyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000221
Super-classes obo:TXPO_0000243c
Restrictions obo:RO_0002234op some (obo:BFO_0000040c and ub744bL44226C17c)

damagingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000222
Description

injury http://purl.obolibrary.org/obo/OGMS_0000102
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0000070c
obo:TXPO_0000225c
obo:NCIT_C16507c
obo:TXPO_0001737c

DNA damage [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000223
Super-classes obo:TXPO_0001727c
obo:NCIT_C16507c
Restrictions obo:RO_0000057op some obo:TXPO_0000641c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000234c
obo:TXPO_0000069op some obo:TXPO_0000453c

TIMP1 production [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000224
Super-classes obo:TXPO_0003742c
obo:TXPO_0000152c
Restrictions obo:RO_0002234op some obo:TXPO_0003062c
obo:TXPO_0000774op only obo:TXPO_0002329c

cellular damagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000225
Super-classes obo:TXPO_0000222c
Sub-classes obo:TXPO_0000227c
obo:TXPO_0005035c
obo:TXPO_0002182c
obo:TXPO_0000226c
obo:TXPO_0004272c

cellular damage [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000226
Super-classes obo:TXPO_0001727c
obo:TXPO_0000225c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000239c
obo:TXPO_0000069op some obo:TXPO_0002129c

cytoskeleton damagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000227
Super-classes obo:TXPO_0000225c

GSTM3 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000228
Super-classes obo:TXPO_0002045c
obo:TXPO_1000180c

GSTA3 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000229
Super-classes obo:TXPO_1000179c
obo:TXPO_0002045c

gene expression by AP-1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000230
Super-classes obo:TXPO_0000375c

membrane blebbing [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000231
Super-classes obo:TXPO_0001727c
obo:GO_0032060c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

increasing membrane permeabilizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000232
Super-classes obo:TXPO_0002704c
Restrictions obo:RO_0002234op some (obo:TXPO_0000895c and ub744bL44362C17c)
obo:BFO_0000066op some obo:TXPO_0000895c
obo:RO_0002233op some obo:TXPO_0000895c
obo:TXPO_0000531op some obo:PATO_0001577c
Sub-classes obo:TXPO_0002706c

positive regulation of mitochondrial membrane permeability [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000233
Super-classes obo:GO_0035794c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000066op some obo:GO_0031966c
obo:TXPO_0000069op some obo:TXPO_0002233c

positive regulation of mitochondrial membrane permeability [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000234
Super-classes obo:GO_0035794c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0003026c

dysregulation of apoptosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000235
Super-classes obo:TXPO_0000532c

tumorigenesis [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000236
Super-classes obo:NCIT_C18121c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:BFO_0000066op some obo:UBERON_0002107c

gene expression by p53c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000237
Super-classes obo:TXPO_0000375c

changing cytoskeletonc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000238
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0000066c
obo:TXPO_0000239c

changing cytoskeleton [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000239
Super-classes obo:TXPO_0000238c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000241c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000246c

hypofunction of keeping structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000240
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:TXPO_0003733c
Sub-classes obo:TXPO_0000241c

hypofunction of keeping structure [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000241
Super-classes obo:TXPO_0001727c
obo:TXPO_0000240c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

decreasing areac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000242
Super-classes obo:TXPO_0000544c
Restrictions obo:TXPO_0000531op some obo:PATO_0002058c
Sub-classes obo:TXPO_0000245c
obo:TXPO_0002648c

decreasing volumec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000243
Super-classes obo:TXPO_0000417c
obo:TXPO_0000220c
Restrictions obo:RO_0002234op some (obo:BFO_0000001c and ub744bL44512C17c)
obo:TXPO_0000531op some obo:PATO_0000596c
Sub-classes obo:TXPO_0000221c

decreasing lengthc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000244
Super-classes obo:TXPO_0000552c
Restrictions obo:TXPO_0000531op some obo:PATO_0000574c

decreasing contact area with ECMc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000245
Super-classes obo:TXPO_0000242c
Sub-classes obo:TXPO_0000246c

decreasing contact area with ECM [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000246
Super-classes obo:TXPO_0001727c
obo:TXPO_0000245c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002122c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000512c

accumulation of substances in a biological objectc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000247
Description

related quality http://purl.obolibrary.org/obo/PATO_0002269
Super-classes obo:TXPO_0000601c
Restrictions obo:BFO_0000066op some obo:UBERON_0001062c
Sub-classes obo:TXPO_0000537c
obo:TXPO_0003179c
obo:TXPO_0000492c
obo:TXPO_0000488c
obo:TXPO_0000960c
obo:TXPO_0003313c
obo:TXPO_0001751c
obo:GO_0043473c
obo:TXPO_0000254c
obo:TXPO_0000169c
obo:TXPO_0003182c
obo:GO_0051208c
obo:TXPO_0004306c
obo:TXPO_0001249c
obo:GO_0019915c
obo:TXPO_0000576c
obo:TXPO_0000248c
obo:TXPO_0003130c

protein accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000248
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_36080c
Sub-classes obo:TXPO_0000251c
obo:TXPO_0000255c

increasing sensitivityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000249
Super-classes obo:TXPO_0000015c

accumulation of abnormal proteins in ER [ER stress (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000250
Super-classes obo:TXPO_0001717c
obo:TXPO_0003528c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002505c
obo:TXPO_0000069op some obo:TXPO_0002114c
obo:TXPO_0000069op some obo:TXPO_0000752c
obo:TXPO_0000774op only obo:TXPO_0002528c

accumulation of abnormal proteinsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000251
Super-classes obo:TXPO_0000248c
Sub-classes obo:TXPO_0002187c

mitochondrial dysfunction [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000252
Super-classes obo:TXPO_0002361c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000346c

increasing size of liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000253
Super-classes obo:TXPO_0000138c

vitamine accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000254
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:IMR_0001656c

accumulation of protein aggregatesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000255
Description

Protein aggretates are often insoluble and tend to sequester Fe 2+ ions. Fe 2+ helps to produce ROS.
Super-classes obo:TXPO_0000248c

fatty acid stroragec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000256
Super-classes obo:GO_0019915c
Restrictions obo:RO_0002233op some obo:TXPO_0000834c
Sub-classes obo:TXPO_0002040c
obo:TXPO_0001387c

substance with stress sensor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000257
Description

This entity is inferred from Description Logic.
Super-classes obo:GOCHE_50906c

melanin depositionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000258
Super-classes obo:GO_0043473c
Restrictions obo:RO_0002233op some obo:TXPO_0003821c

lipofuscin depositionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000259
Super-classes obo:GO_0043473c
Restrictions obo:RO_0002233op some obo:TXPO_0003820c

substance with apoptosis inducer rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000260
Description

This entity is inferred from Description Logic.
Super-classes obo:GOCHE_50906c

changing relationship between operandsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000261
Super-classes obo:TXPO_0000387c
Sub-classes obo:TXPO_0000464c
obo:TXPO_0000333c
obo:TXPO_0000024c
obo:TXPO_0002590c
obo:TXPO_0001847c
obo:GO_0008152c
obo:TXPO_0001979c
obo:TXPO_0002568c
obo:TXPO_0000441c

ATP depletion [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000262
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0000368c
obo:BFO_0000051op some obo:TXPO_0000167c
obo:TXPO_0000004op only obo:TXPO_0000485c
obo:BFO_0000051op some obo:TXPO_0000366c
obo:BFO_0000051op some obo:TXPO_0000485c
obo:BFO_0000051op some obo:TXPO_0000218c
obo:BFO_0000051op some obo:TXPO_0000367c
obo:BFO_0000051op some obo:TXPO_0000207c
obo:BFO_0000051op some obo:TXPO_0000354c

bile acid accumulation in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000263
Super-classes obo:TXPO_0003130c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0000264c
obo:TXPO_0002759c

bile acid accumulation in hepatocyte [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000264
Super-classes obo:TXPO_0000034c
obo:TXPO_0000263c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000069op some obo:TXPO_0000265c

increasing hepatocellular volume [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000265
Super-classes obo:TXPO_0000034c
obo:TXPO_0000164c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

ubiquitin ligasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000266
Super-classes obo:TXPO_0000171c

increasing amount of carbohydratec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000267
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003809c

bile acid biosynthetic process [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000268
Super-classes obo:GO_0006699c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:BFO_0000066op some obo:UBERON_0002107c

bile acid transport to hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000269
Super-classes obo:GO_0015721c
Restrictions obo:RO_0002339op some obo:CL_0000182c

statec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000270
Description

Location-independent. State corresponds not to generic quality but to property. It is possessed by continuants and processes.
Super-classes obo:BFO_0000003c
Sub-classes obo:TXPO_0001736c
obo:TXPO_0003992c
obo:TXPO_0001734c
obo:TXPO_0001735c
obo:TXPO_0001746c

primitive processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000271
Description

Whether the process is a primitive process or not depends on the setting of the granularity. When one does not consider the details more than a certain level, or a level as the minimum grain size, the process at that level becomes the primitive process.
Super-classes obo:BFO_0000015c
Restrictions obo:RO_0002501op only obo:BFO_0000015c
obo:BFO_0000051op some obo:BFO_0000015c
Sub-classes obo:TXPO_0000145c
obo:TXPO_0000808c
obo:TXPO_0001715c

OATPS family (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000272
Description

glibenclamide is a potential substrate for OATPs.
Super-classes obo:TXPO_0000276c
obo:TXPO_1000270c
Restrictions obo:TXPO_0002260op some ncicp:C107150c
Sub-classes obo:TXPO_0001504c
obo:TXPO_0003127c
obo:TXPO_0000743c
obo:TXPO_0000724c

cholestasis dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000273
Description

under construction
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
Sub-classes obo:TXPO_0000276c
obo:TXPO_0000749c

PERK signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000274
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0000285c
Sub-classes obo:TXPO_0000454c

quality valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000275
Super-classes obo:BFO_0000031c
Sub-classes obo:TXPO_0000277c
obo:TXPO_0000278c
In range of obo:TXPO_0000826op

cholestasis dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000276
Description

under construction
Super-classes obo:TXPO_0000273c
Sub-classes obo:TXPO_0000547c
obo:TXPO_0002726c
obo:TXPO_0000272c
obo:TXPO_0001506c
obo:TXPO_0002643c
obo:TXPO_0002724c
obo:TXPO_0002647c
obo:TXPO_0003148c
obo:TXPO_0002725c
obo:TXPO_0002723c
obo:TXPO_0000715c
obo:TXPO_0003125c

categoricalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000277
Super-classes obo:TXPO_0000275c
Sub-classes obo:TXPO_0002426c
obo:TXPO_0001510c
obo:TXPO_0004322c

quantityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000278
Super-classes obo:TXPO_0000275c
Sub-classes obo:TXPO_0000288c
obo:TXPO_0000289c

dysfunction of fatty acid degradation [Alcoholic fatty liver]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000279
Super-classes obo:TXPO_0003361c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004207c
obo:BFO_0000051op some obo:TXPO_0001739c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000066op some obo:CL_0000182c

tumor cell survialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000280
Super-classes obo:NCIT_C16407c
Sub-classes obo:TXPO_0000836c
obo:TXPO_0004919c
obo:TXPO_0003490c

phospholipid accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000281
Super-classes obo:TXPO_0001244c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
Sub-classes obo:TXPO_0001697c
obo:TXPO_0001763c
obo:TXPO_0000910c

LPL (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000282
Description

lipoprotein lipase
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:PR_000009897c
obo:TXPO_0000819op some obo:OGG_3000004023c
Sub-classes obo:TXPO_0002062c

converting to acetyl CoAc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000283
Super-classes obo:GO_0008152c
Sub-classes obo:TXPO_0003808c

Increaseing fatty acid synthesis substratec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000284
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003807c

PERK signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000285
Super-classes obo:TXPO_0000609c
Restrictions obo:BFO_0000051op some obo:TXPO_0001837c
obo:BFO_0000051op some obo:TXPO_0000454c
Sub-classes obo:GO_0036499c

large (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000286
Super-classes obo:TXPO_0000288c
Sub-classes obo:TXPO_0001567c

small (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000287
Super-classes obo:TXPO_0000288c
Sub-classes obo:TXPO_0001574c

qualitative quantityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000288
Super-classes obo:TXPO_0000278c
Sub-classes obo:TXPO_0001459c
obo:TXPO_0004208c
obo:TXPO_0000287c
obo:TXPO_0000286c

meta attribute valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000289
Super-classes obo:TXPO_0000278c
Sub-classes obo:TXPO_0000290c
obo:TXPO_0000293c

numbers quality valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000290
Super-classes obo:TXPO_0000289c
Sub-classes obo:TXPO_0000292c
obo:TXPO_0000291c

manyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000291
Super-classes obo:TXPO_0000290c

fewc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000292
Super-classes obo:TXPO_0000290c

times quality valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000293
Super-classes obo:TXPO_0000289c
Sub-classes obo:TXPO_0000294c
obo:TXPO_0000295c

many timesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000294
Super-classes obo:TXPO_0000293c

few timesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000295
Super-classes obo:TXPO_0000293c

acute phase proteins coding gene expression via cytokinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000296
Description

IL-1, TNF, IL-6 or other cytokines released from macrophages and endtherial cells act on cell surface receptors to change transcriptions of genes involving tissue injury and repair.
Super-classes obo:GO_0010467c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000535c

oxidative dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000297
Description

under construction
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c
Sub-classes obo:TXPO_0000594c
obo:TXPO_0000360c
obo:TXPO_0000596c
obo:TXPO_0000592c

EDEM (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000298
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009695c
Sub-classes obo:TXPO_0002699c

ABCB11 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000299
Description

Bosentan, cyclosporin, glibenclamide, rifampicin, and rifamycin inhibit human and rat BSEP/Bsep.
Super-classes obo:TXPO_0001506c
Restrictions obo:RO_0000087op some obo:TXPO_0000506c

attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000300
Super-classes obo:BFO_0000020c
Sub-classes obo:TXPO_0000305c
obo:TXPO_0000309c
In domain of obo:TXPO_0000826op
In range of obo:TXPO_0001862op

PERK - stress sensor (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000301
Super-classes obo:TXPO_0001792c
obo:TXPO_0000871c
obo:TXPO_0001841c
Restrictions obo:RO_0000087op some obo:TXPO_0000881c
obo:TXPO_0000774op only obo:TXPO_0002528c

counting generic qualityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000302
Super-classes obo:TXPO_0000309c
Sub-classes obo:TXPO_0000304c
obo:TXPO_0000303c

number of timesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000303
Description

not clock time but times (how many times). Contrary to the intuition, "times" should not be taken as a generic quality. What should be taken as a generic quality is the pai rof "event" and times. That is, "what event happens many times" corresponds to "color is red". For example, "A month which has many accidents" corresponds to "A rose whose color is red".
Super-classes obo:TXPO_0000302c

number of objectsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000304
Super-classes obo:TXPO_0000302c

non-meta generic qualityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000305
Super-classes obo:TXPO_0000300c
Sub-classes obo:TXPO_0001334c
obo:TXPO_0002415c
obo:TXPO_0003683c
obo:TXPO_0003744c
obo:TXPO_0002419c
obo:TXPO_0000865c
obo:TXPO_0002425c
obo:TXPO_0002423c
obo:TXPO_0002422c
obo:TXPO_0003729c
obo:TXPO_0000311c
obo:TXPO_0002414c
obo:TXPO_0002420c
obo:TXPO_0001536c
obo:TXPO_0002429c
obo:TXPO_0001299c
obo:TXPO_0000825c
obo:TXPO_0002413c
obo:TXPO_0002416c
obo:TXPO_0002417c
obo:TXPO_0001881c
obo:TXPO_0002418c
obo:TXPO_0003521c
obo:TXPO_0004211c
obo:TXPO_0000310c

protein biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000306
Super-classes obo:GO_0009058c
Restrictions obo:RO_0002234op some obo:CHEBI_36080c
Sub-classes obo:GO_0042158c

weight attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000307
Super-classes obo:TXPO_0002419c

lyasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000308
Description

related molecular function GO:0016829
Super-classes obo:TXPO_0003660c
Sub-classes obo:TXPO_0000804c

meta generic qualityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000309
Super-classes obo:TXPO_0000300c
Sub-classes obo:TXPO_0000302c

area (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000310
Super-classes obo:TXPO_0000305c
Sub-classes obo:TXPO_0003626c

color (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000311
Super-classes obo:TXPO_0000305c

moving drug to the inside of liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000312
Super-classes obo:TXPO_0002587c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:RO_0002233op some (obo:BFO_0000002c and ub744bL45240C17c)
Sub-classes obo:TXPO_0001714c

tamoxifen [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000313
Super-classes obo:CHEBI_41774c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0001426c

apoptosis [liver tumor via ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000314
Super-classes obo:TXPO_0001026c
obo:GO_0006915c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001031c
obo:TXPO_0000774op only obo:TXPO_0003866c

colorness (quality)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000315
Super-classes obo:PATO_0000068c

high brightnessc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000316
Super-classes obo:PATO_0000016c

amiodarone_CAD [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000317
Super-classes obo:CHEBI_2663c
obo:TXPO_0001849c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0000087op some obo:TXPO_0001426c

gentamicin_sphingomyelinase inhibitor [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000318
Super-classes obo:TXPO_0001849c
obo:CHEBI_17833c
Restrictions obo:RO_0000087op some obo:CHEBI_76811c

tamoxifen phospholipase inhibitor[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000319
Super-classes obo:CHEBI_41774c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0003220c
obo:RO_0000087op some obo:TXPO_0001426c

acute phase response rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000320
Super-classes obo:TXPO_0003728c

FADs2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000321
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003348c
Sub-classes obo:TXPO_0003346c

myelin figureformation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000322
Super-classes obo:TXPO_0000134c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
Sub-classes obo:TXPO_0004148c

cell death (toxic course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000323
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0000008c
obo:TXPO_0000004op some obo:TXPO_0000008c
obo:BFO_0000051op some obo:TXPO_0003829c
Sub-classes obo:TXPO_0000678c
obo:TXPO_0000326c
obo:TXPO_0002148c
obo:TXPO_0000324c

apoptosis (course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000324
Description

under construction
Super-classes obo:TXPO_0000323c
Restrictions obo:BFO_0000051op some obo:TXPO_0002137c
obo:BFO_0000051op some obo:TXPO_0003026c
obo:BFO_0000051op some obo:TXPO_0000573c
obo:BFO_0000051op some obo:TXPO_0002390c
obo:BFO_0000051op some obo:TXPO_0000223c
obo:BFO_0000051op some obo:TXPO_0000453c
obo:BFO_0000051op some obo:TXPO_0002403c
obo:BFO_0000051op some obo:TXPO_0000448c
obo:TXPO_0000004op some obo:TXPO_0000514c
obo:BFO_0000051op some obo:TXPO_0002125c
obo:BFO_0000051op some obo:TXPO_0002128c
obo:BFO_0000051op some obo:TXPO_0000374c
obo:BFO_0000051op some obo:TXPO_0000234c
obo:BFO_0000051op some obo:TXPO_0002135c
obo:BFO_0000051op some obo:TXPO_0000377c
obo:BFO_0000051op some obo:TXPO_0000446c
obo:BFO_0000051op some obo:TXPO_0000574c
obo:BFO_0000051op some obo:TXPO_0000514c
obo:BFO_0000051op some obo:TXPO_0003737c

increasing drug metabolite [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000325
Super-classes obo:TXPO_0001728c
obo:TXPO_0002364c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

pyroptosis (course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000326
Description

under construction
Super-classes obo:TXPO_0000323c
Restrictions obo:BFO_0000051op some obo:TXPO_0002140c
obo:BFO_0000051op some obo:TXPO_0003831c
obo:BFO_0000051op some obo:TXPO_0002141c
obo:BFO_0000051op some obo:TXPO_0003830c
obo:BFO_0000051op some obo:TXPO_0002144c
obo:TXPO_0000004op some obo:TXPO_0002144c

apoptosis regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000327
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0006915c
Sub-classes obo:CHEBI_68494c
obo:CHEBI_68495c

ion channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000328
Description

related molecular function GO:0005216
Super-classes obo:TXPO_0003639c
Sub-classes obo:TXPO_0002803c
obo:TXPO_0001900c
obo:TXPO_0003680c

inhibitor of tumor cell activity rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000329
Super-classes obo:TXPO_0003725c

transcription regulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000330
Description

related molecular function GO:0140110
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0006351c
Sub-classes obo:TXPO_0003947c
obo:TXPO_0001531c
obo:TXPO_0003644c
obo:TXPO_0003716c

drug transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000331
Description

related molecular function GO:0015238
Super-classes obo:TXPO_0003698c

genomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000332
Super-classes obo:GO_0005575c
Restrictions obo:BFO_0000051op some obo:OGG_0000000002c

separatingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000333
Description

separating into multiple components
Super-classes obo:TXPO_0000261c
Sub-classes obo:TXPO_0003076c
obo:TXPO_0002576c
obo:GO_0006508c
obo:TXPO_0003077c
obo:GO_0008380c
obo:TXPO_0000343c
obo:TXPO_0000046c
obo:TXPO_0000048c
obo:TXPO_0000462c
obo:GO_0006379c
obo:TXPO_0002577c

hyperfunction of Kupffer cell differentiation [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000334
Super-classes obo:TXPO_0000636c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0003431c

ATF6 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000335
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002126c
Sub-classes obo:TXPO_0000718c

amino acid conjugatied bile acid transport into bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000336
Super-classes obo:GO_0015722c
Restrictions obo:RO_0002339op some obo:UBERON_0001283c
Sub-classes obo:TXPO_0000356c

changing fluidityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000337
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000412c

cell proliferation [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000338
Super-classes obo:TXPO_0001727c
obo:GO_0008283c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

tumor cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000339
Super-classes obo:GO_0008283c
Restrictions obo:RO_0002234op some (ub744bL45617C33c and ub744bL45627C17c)
Sub-classes obo:TXPO_0001030c
obo:TXPO_0002535c
obo:TXPO_0003232c
obo:TXPO_0001491c
obo:TXPO_0004518c
obo:TXPO_0000340c

tumor cell proliferation [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000340
Super-classes obo:TXPO_0001727c
obo:TXPO_0000339c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

increasing number of dead cells in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000341
Super-classes obo:TXPO_0000093c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:RO_0002234op some (ub744bL45660C33c and ub744bL45670C17c)
Sub-classes obo:TXPO_0001217c
obo:TXPO_0002372c
obo:TXPO_0000342c
obo:TXPO_0001031c
obo:TXPO_0003596c
obo:TXPO_0003312c
obo:TXPO_0002333c

increasing number of dead cells in liver [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000342
Super-classes obo:TXPO_0001717c
obo:TXPO_0000341c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003598c
obo:TXPO_0000069op some obo:TXPO_0002533c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0000760c

decomposingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000343
Super-classes obo:TXPO_0000333c
Sub-classes obo:GO_0022411c
obo:TXPO_0000185c

increasing number of actionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000344
Super-classes obo:TXPO_0000387c
Sub-classes obo:TXPO_0000484c
obo:TXPO_0000216c

increasing autodigestion of abnormal lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000345
Super-classes obo:TXPO_0000484c

hypofunction of ATP biosynthesis [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000346
Super-classes obo:TXPO_0001722c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000486c
obo:TXPO_0000774op only obo:TXPO_0000323c

increasing number of bile duct in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000347
Super-classes obo:TXPO_0000093c
Restrictions obo:RO_0002234op some (obo:UBERON_0002394c and ub744bL45749C17c)

decreasing number of objectsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000348
Super-classes obo:TXPO_0000387c
Restrictions obo:RO_0002234op some (obo:BFO_0000040c and ub744bL45768C17c)
obo:TXPO_0000531op some obo:TXPO_0003758c
Sub-classes obo:TXPO_0001479c
obo:TXPO_0000351c
obo:TXPO_0003393c

cleavage of ATF6-alpha by S2P [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000349
Super-classes obo:TXPO_0000046c
obo:TXPO_0003736c
Restrictions obo:RO_0002233op some obo:IMR_0000831c
obo:TXPO_0000774op only obo:TXPO_0002528c

cholestasis process [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000350
Super-classes obo:TXPO_0001345c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000069op some obo:TXPO_0000264c

decreasing number of cellsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000351
Super-classes obo:TXPO_0000348c
Restrictions obo:RO_0002234op some (obo:CL_0000000c and ub744bL45821C17c)
Sub-classes obo:TXPO_0003390c

increasing concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000352
Super-classes obo:TXPO_0002438c
Restrictions obo:TXPO_0000531op some obo:PATO_0001162c
Sub-classes obo:TXPO_0001912c
obo:TXPO_0001377c
obo:TXPO_0001914c
obo:TXPO_0001337c
obo:TXPO_0000353c
obo:TXPO_0002715c
obo:TXPO_0001346c
obo:TXPO_0001372c
obo:TXPO_0001347c
obo:TXPO_0000852c
obo:TXPO_0005043c
obo:TXPO_0001355c
obo:TXPO_0001292c
obo:TXPO_0003950c
obo:TXPO_0001349c
obo:TXPO_0000643c

increasing calcium ion concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000353
Super-classes obo:TXPO_0000352c
Sub-classes obo:TXPO_0004989c
obo:TXPO_0000354c

increase in intracellular calcium levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000354
Super-classes obo:TXPO_0000353c
Sub-classes obo:TXPO_0002227c
obo:TXPO_0000355c

increase in intracellular calcium level [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000355
Super-classes obo:TXPO_0000354c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001727c
obo:TXPO_0000069op some obo:TXPO_0002381c

amino acid conjugatied bile acid transport into bile canaliculus [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000356
Super-classes obo:TXPO_0000336c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000299c

PERK activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000357
Super-classes obo:TXPO_0000023c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001852c
obo:RO_0002234op some (obo:TXPO_0001792c and ub744bL45888C17c)
obo:TXPO_0000012op some obo:TXPO_0000742c
obo:TXPO_0000012op some obo:TXPO_0000712c
Sub-classes obo:TXPO_0000586c

AMPK activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000358
Super-classes obo:TXPO_0000405c
obo:TXPO_0003736c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000451c
obo:TXPO_0000069op some obo:TXPO_0001455c
obo:RO_0000057op some obo:TXPO_0000873c
obo:TXPO_0000774op only obo:TXPO_0002528c

decreasing blood flowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000359
Super-classes obo:TXPO_0002672c
Sub-classes obo:TXPO_0003781c
obo:TXPO_0001335c
obo:TXPO_0003315c
obo:TXPO_0001336c

Oxidative dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000360
Super-classes obo:TXPO_0000297c

increasing demand for response to stressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000361
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0000362c
obo:TXPO_0000102c

increasing demand for response to ER stressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000362
Super-classes obo:TXPO_0000361c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:BFO_0000051op some obo:TXPO_0002211c
Sub-classes obo:TXPO_0004541c
obo:TXPO_0004340c
obo:TXPO_0000687c
obo:TXPO_0000688c
obo:TXPO_0000573c
obo:TXPO_0000734c

increasing demand for response to ER stress [ER stress (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000363
Super-classes obo:TXPO_0000734c

increasing production quantity of ROSc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000364
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004794c

increasing production quantity of RNSc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000365
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004718c

increasing calcium ion inflow into cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000366
Super-classes obo:TXPO_0000395c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000354c

increasing sodium ion inflow into cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000367
Super-classes obo:TXPO_0000395c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000218c

increasing extracellular potassium outflowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000368
Super-classes obo:TXPO_0000395c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000218c

negative regulation processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000369
Description

Controlling to the negative (-) direction.
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002212op some obo:BFO_0000015c
Sub-classes obo:TXPO_0004994c
obo:TXPO_0002056c
obo:GO_0045721c
obo:TXPO_0004980c
obo:TXPO_0003155c
obo:GO_0010629c
obo:GO_1902576c
obo:GO_0023057c
obo:TXPO_0001771c
obo:TXPO_0002124c
obo:TXPO_0004903c
obo:TXPO_0002054c
obo:TXPO_0000548c
obo:TXPO_0004133c
obo:TXPO_0000115c
obo:TXPO_0002342c
obo:GO_1901889c
obo:TXPO_0002537c
obo:GO_0010888c
obo:TXPO_0002682c
obo:GO_0045738c
obo:TXPO_0002243c
obo:TXPO_0004212c
obo:TXPO_0005004c
obo:GO_0051055c
obo:TXPO_0003978c
obo:TXPO_0001402c
obo:TXPO_0003813c
obo:TXPO_0004878c
obo:GO_0045806c
obo:GO_0010716c
obo:TXPO_0001787c
obo:TXPO_0004014c
obo:TXPO_0001946c
obo:TXPO_0004962c
obo:TXPO_0000068c
obo:TXPO_0001516c
obo:GO_2000773c
obo:TXPO_0000883c
obo:TXPO_0004572c
obo:TXPO_0003882c
obo:GO_1903427c
obo:GO_0046676c

negative regulation of cell cycle G2/M phase transitionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000370
Super-classes obo:TXPO_0000548c
Sub-classes obo:TXPO_0002055c
obo:TXPO_0004246c

negative regulation of apoptotic process [ER stress (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000371
Super-classes obo:TXPO_0001717c
obo:GO_0043066c
Restrictions obo:RO_0000057op some obo:TXPO_0000087c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0003471c

EVOL6c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000372
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003325c

drug metabolism phase I by Cytochrome P450 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000373
Super-classes obo:TXPO_0001559c
obo:TXPO_0001728c
Restrictions obo:BFO_0000066op some obo:GO_0005790c
obo:BFO_0000051op some obo:TXPO_0001607c
obo:TXPO_0000774op only obo:TXPO_0001432c

regulation of cell cycle [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000374
Super-classes obo:GO_0051726c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002137c

Gene expression by transcriptional regulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000375
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0003146c
obo:TXPO_0001874c
obo:TXPO_0002770c
obo:TXPO_0002606c
obo:TXPO_0000237c
obo:TXPO_0000230c
obo:TXPO_0002433c
obo:TXPO_0002521c
obo:TXPO_0002763c
obo:TXPO_0000672c

cell survival [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000376
Super-classes obo:TXPO_0001717c
obo:NCIT_C16407c
Restrictions obo:RO_0000057op some obo:TXPO_0000798c
obo:RO_0000057op some obo:TXPO_0000768c
obo:TXPO_0000774op only obo:TXPO_0002528c

normal cell survival [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000377
Super-classes obo:NCIT_C16407c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

functioning processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000378
Super-classes obo:TXPO_0000145c
Sub-classes obo:TXPO_0000379c
obo:TXPO_0000380c
obo:TXPO_0000381c
In range of obo:TXPO_0000716op

receivingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000379
Super-classes obo:TXPO_0000378c
Restrictions obo:RO_0002233op some obo:BFO_0000002c
Sub-classes obo:GO_0006910c
obo:TXPO_0000601c
obo:TXPO_0002174c

making existencec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000380
Super-classes obo:TXPO_0000378c
Sub-classes obo:TXPO_0000968c
obo:TXPO_0000387c
obo:TXPO_0000741c

generatingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000381
Super-classes obo:TXPO_0000378c
Restrictions obo:RO_0002234op some obo:BFO_0000002c
Sub-classes obo:TXPO_0001880c
obo:TXPO_0000019c
obo:TXPO_0000765c
obo:TXPO_0000011c
obo:GO_0031649c

protein productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000382
Super-classes obo:TXPO_0000019c
Restrictions obo:BFO_0000051op some obo:GO_0006412c
obo:RO_0002234op some obo:CHEBI_36080c
Sub-classes obo:TXPO_0002153c
obo:TXPO_0000820c
obo:TXPO_0004282c
obo:TXPO_0005048c
obo:TXPO_0000385c
obo:TXPO_0004641c
obo:TXPO_0000107c
obo:TXPO_0000818c
obo:TXPO_0000152c
obo:TXPO_0002183c
obo:TXPO_0000384c
obo:TXPO_0004285c
obo:GO_0001816c

abnormal protein-degrading enzyme production [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000383
Super-classes obo:TXPO_0000385c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

chaperon productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000384
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0002384c

abnormal protein-degrading enzyme productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000385
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0000383c

positive regulation of ERAD [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000386
Super-classes obo:TXPO_0001717c
obo:GO_1904294c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0000728c
obo:TXPO_0000069op some obo:TXPO_0002204c

changingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000387
Super-classes obo:TXPO_0000380c
Sub-classes obo:TXPO_0000344c
obo:TXPO_0000392c
obo:TXPO_0000261c
obo:TXPO_0000093c
obo:TXPO_0000348c

PERK autophosphorylation [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000388
Super-classes obo:TXPO_0000674c
Restrictions obo:RO_0000057op some obo:TXPO_0002858c
obo:TXPO_0000774op only obo:TXPO_0002528c

converting signal to informationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000389
Super-classes obo:TXPO_0002567c
Restrictions obo:TXPO_0000069op some obo:GO_0010467c
Sub-classes obo:TXPO_0000391c
obo:TXPO_0000390c

converting signal to information [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000390
Super-classes obo:TXPO_0001717c
obo:TXPO_0000389c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

converting signal to information [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000391
Super-classes obo:TXPO_0000389c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

changing an operandc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000392
Super-classes obo:TXPO_0000387c
Sub-classes obo:TXPO_0002282c
obo:TXPO_0001984c
obo:GO_0090398c
obo:TXPO_0000415c
obo:TXPO_0000535c
obo:TXPO_0001985c
obo:TXPO_0000394c
obo:TXPO_0000425c
obo:TXPO_0002566c
obo:TXPO_0000429c

membrane phospholipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000393
Super-classes obo:GO_0009395c
Restrictions obo:BFO_0000066op some obo:TXPO_0000895c
obo:RO_0002233op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0002138c

changing quantityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000394
Super-classes obo:TXPO_0000392c
Sub-classes obo:TXPO_0000414c
obo:TXPO_0000396c
obo:TXPO_0000395c

increasing quantityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000395
Super-classes obo:TXPO_0000394c
Restrictions obo:TXPO_0000531op some obo:PATO_0000470c
Sub-classes obo:TXPO_0005012c
obo:TXPO_0003151c
obo:TXPO_0004938c
obo:TXPO_0004697c
obo:TXPO_0004569c
obo:TXPO_0004615c
obo:TXPO_0001409c
obo:TXPO_0001075c
obo:TXPO_0004653c
obo:TXPO_0000368c
obo:TXPO_0000365c
obo:TXPO_0004456c
obo:TXPO_0001101c
obo:TXPO_0000524c
obo:TXPO_0004411c
obo:TXPO_0000144c
obo:TXPO_0004520c
obo:TXPO_0001251c
obo:TXPO_0003144c
obo:TXPO_0004765c
obo:TXPO_0003493c
obo:TXPO_0005052c
obo:TXPO_0004668c
obo:TXPO_0004856c
obo:TXPO_0002364c
obo:TXPO_0001790c
obo:TXPO_0000366c
obo:TXPO_0005054c
obo:TXPO_0000284c
obo:TXPO_0004550c
obo:TXPO_0004618c
obo:TXPO_0002714c
obo:TXPO_0004580c
obo:TXPO_0004982c
obo:TXPO_0004680c
obo:TXPO_0002229c
obo:TXPO_0004777c
obo:TXPO_0000618c
obo:TXPO_0004624c
obo:TXPO_0000267c
obo:TXPO_0005030c
obo:TXPO_0004802c
obo:TXPO_0004524c
obo:TXPO_0005027c
obo:TXPO_0004716c
obo:TXPO_0005023c
obo:TXPO_0004781c
obo:TXPO_0004945c
obo:TXPO_0004130c
obo:TXPO_0001631c
obo:TXPO_0004743c
obo:TXPO_0003492c
obo:TXPO_0004605c
obo:TXPO_0000633c
obo:TXPO_0004405c
obo:TXPO_0004463c
obo:TXPO_0001255c
obo:TXPO_0001062c
obo:TXPO_0004935c
obo:TXPO_0004690c
obo:TXPO_0001250c
obo:TXPO_0004485c
obo:TXPO_0000088c
obo:TXPO_0004398c
obo:TXPO_0004473c
obo:TXPO_0004790c
obo:TXPO_0001541c
obo:TXPO_0000364c
obo:TXPO_0004734c
obo:TXPO_0004471c
obo:TXPO_0001421c
obo:TXPO_0004973c
obo:TXPO_0000367c
obo:TXPO_0002248c
obo:TXPO_0004437c
obo:TXPO_0004968c

decreasing quantityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000396
Super-classes obo:TXPO_0000394c
Restrictions obo:TXPO_0000531op some obo:TXPO_0002450c
Sub-classes obo:TXPO_0004573c
obo:TXPO_0004921c
obo:TXPO_0000644c
obo:TXPO_0004138c
obo:TXPO_0004943c
obo:TXPO_0004940c
obo:TXPO_0001830c
obo:TXPO_0002672c
obo:TXPO_0004310c
obo:TXPO_0004475c
obo:TXPO_0002305c
obo:TXPO_0004771c
obo:TXPO_0002080c
obo:TXPO_0004905c
obo:TXPO_0003140c
obo:TXPO_0004684c
obo:TXPO_0003962c
obo:TXPO_0004564c
obo:TXPO_0000822c
obo:TXPO_0000602c
obo:TXPO_0000508c
obo:TXPO_0002059c
obo:TXPO_0004490c
obo:TXPO_0002253c
obo:TXPO_0002050c
obo:TXPO_0004886c

decreasing production quantity of protein [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000397
Super-classes obo:TXPO_0001717c
obo:TXPO_0001830c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

hyperfunction of hypoxia resonsive gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000398
Super-classes obo:TXPO_0002345c

gene expression [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000399
Super-classes obo:GO_0010467c

uncoupling dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000400
Description

under construction
Super-classes obo:TXPO_0002012c
Sub-classes obo:TXPO_0002014c

activatingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000401
Super-classes obo:TXPO_0000020c
Restrictions obo:RO_0002234op some (obo:BFO_0000001c and ub744bL46381C17c)
Sub-classes obo:TXPO_0000507c
obo:TXPO_0000023c
obo:TXPO_0001107c
obo:GO_0001775c
obo:TXPO_0001338c
obo:TXPO_0005001c

PERK activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000402
Super-classes obo:TXPO_0000586c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0000713c
obo:TXPO_0000012op some obo:TXPO_0000674c
Sub-classes obo:TXPO_0002514c
obo:TXPO_0002750c
obo:TXPO_0002515c
obo:TXPO_0002854c
obo:TXPO_0003002c
obo:TXPO_0002516c

NRF2 activation by PERK [ER stress (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000403
Description

Mild ER stress activates Nrf2 and the antiapoptotic factor BI-1. Activation of Nrf2 through its phosphorylation by PERK,and BI-1 protect the endoplasmic reticulum from further damage by inhibiting the production of ROS by CYP2E1(Lee et al., 2007; Kim et al., 2009).
Super-classes obo:TXPO_0001370c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000450c
obo:TXPO_0000069op some obo:TXPO_0002746c

Cyp7a1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000404
Super-classes obo:TXPO_0001558c
Sub-classes obo:TXPO_0000715c

AMPK activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000405
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_0003221c and ub744bL46445C17c)
Sub-classes obo:TXPO_0003921c
obo:TXPO_0000358c
obo:TXPO_0003979c

positive regulation of autophagy by AMPKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000406
Super-classes obo:GO_0010508c

GRP78 activation by MLXc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000407
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_0001002c and ub744bL46471C17c)
obo:TXPO_0000069op some obo:TXPO_0000405c

PLA2 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000408
Super-classes obo:TXPO_0000023c

protease activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000409
Super-classes obo:TXPO_0000023c

changing shapec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000410
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0004888c

liver X receptor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000411
Super-classes obo:TXPO_0000158c
Restrictions obo:RO_0002234op some (obo:TXPO_0001120c and ub744bL46513C17c)
Sub-classes obo:TXPO_0001117c

changing membrane fluidityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000412
Super-classes obo:TXPO_0000337c
Restrictions obo:BFO_0000066op some obo:TXPO_0000895c
Sub-classes obo:TXPO_0000084c
obo:TXPO_0000010c

positive regulation of protein refolding [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000413
Super-classes obo:TXPO_0001717c
obo:GO_1904592c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002175c
obo:BFO_0000051op some obo:TXPO_0002716c

keeping quantityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000414
Super-classes obo:TXPO_0000394c
Sub-classes obo:TXPO_0001169c
obo:NCIT_C16407c
obo:TXPO_0003357c
obo:TXPO_0001649c

changing qualityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000415
Super-classes obo:TXPO_0000392c
Restrictions obo:RO_0002234op some (obo:BFO_0000040c and ub744bL46580C17c and obo:BFO_0000040c and ub744bL46567C17c)
obo:RO_0002234op some (obo:BFO_0000040c and ub744bL46580C17c and obo:BFO_0000040c and ub744bL46567C17c)
Sub-classes obo:TXPO_0000699c
obo:TXPO_0000417c
obo:TXPO_0002046c
obo:TXPO_0002705c
obo:TXPO_0000552c
obo:TXPO_0000544c
obo:TXPO_0000020c
obo:TXPO_0000589c
obo:TXPO_0000337c
obo:TXPO_0000475c
obo:TXPO_0002438c
obo:TXPO_0001616c
obo:TXPO_0000015c
obo:TXPO_0000022c
obo:TXPO_0001505c
obo:TXPO_0005141c
obo:TXPO_0000474c
obo:TXPO_0001456c
obo:TXPO_0000422c
obo:TXPO_0000476c
obo:TXPO_0000424c
obo:TXPO_0002704c
obo:TXPO_0003797c
obo:TXPO_0001520c

negative regulation of formation of cytoplasmic translation initiation complex by eIF2a [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000416
Super-classes obo:TXPO_0000068c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002555c

changing volumec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000417
Super-classes obo:TXPO_0000415c
Restrictions obo:RO_0002234op some (obo:BFO_0000040c and ub744bL46628C17c)
obo:RO_0002233op some obo:BFO_0000040c
Sub-classes obo:TXPO_0000243c
obo:TXPO_0000421c
obo:TXPO_0000139c

homeostatic imbalance of number of smooth endoplasmic reticulumc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000418
Super-classes obo:TXPO_0000567c

process based on specific viewpointc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000420
Super-classes obo:BFO_0000015c
Sub-classes obo:TXPO_0000538c

keeps volumec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000421
Super-classes obo:TXPO_0000417c

changing densityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000422
Super-classes obo:TXPO_0000415c

biological defense rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000423
Super-classes obo:TXPO_0003230c

changing hardnessc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000424
Super-classes obo:TXPO_0000415c
Restrictions obo:TXPO_0000531op some obo:PATO_0000048c
Sub-classes obo:TXPO_0002202c

changing phasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000425
Super-classes (ub744bL46690C29c and ub744bL46695C13c)
obo:TXPO_0000392c
Sub-classes obo:TXPO_0000427c
obo:TXPO_0000426c
obo:TXPO_0000428c
obo:GO_0044770c
obo:GO_0007049c

solidifyingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000426
Super-classes obo:TXPO_0000425c

vaporizingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000427
Super-classes obo:TXPO_0000425c

liquefyingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000428
Super-classes obo:TXPO_0000425c

movingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000429
Description

act on one position
Super-classes obo:TXPO_0000392c
Sub-classes obo:TXPO_0000799c
obo:TXPO_0000433c
obo:TXPO_0000432c
obo:TXPO_0000003c
obo:TXPO_0000431c
obo:TXPO_0000430c

elevatingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000430
Super-classes obo:TXPO_0000429c

loweringc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000431
Super-classes obo:TXPO_0000429c

moving fluidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000432
Super-classes obo:TXPO_0000429c

keeping positionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000433
Super-classes obo:TXPO_0000429c
Sub-classes obo:GO_0007253c
obo:TXPO_0004880c

malfunctioning processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000434
Super-classes obo:TXPO_0000145c
Sub-classes obo:TXPO_0000439c
obo:TXPO_0001718c
obo:TXPO_0001454c
obo:TXPO_0002073c
obo:TXPO_0000437c
obo:TXPO_0003267c
obo:TXPO_0001453c
obo:TXPO_0005015c
obo:TXPO_0000436c
obo:TXPO_0001846c
obo:TXPO_0002156c
obo:TXPO_0000532c
obo:TXPO_0005033c
obo:TXPO_0002130c
obo:TXPO_0000435c
obo:TXPO_0002198c
obo:TXPO_0000782c

hyperfunctioningc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000435
Super-classes obo:TXPO_0000434c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000271c
Sub-classes obo:TXPO_0003433c
obo:TXPO_0002351c
obo:TXPO_0002346c
obo:TXPO_0001272c
obo:TXPO_0001228c
obo:TXPO_0001681c
obo:TXPO_0001724c
obo:TXPO_0001227c
obo:TXPO_0002279c
obo:TXPO_0002063c
obo:TXPO_0002303c
obo:TXPO_0002718c
obo:TXPO_0001486c
obo:TXPO_0002349c
obo:TXPO_0001361c
obo:TXPO_0000098c
obo:TXPO_0002360c
obo:TXPO_0003883c
obo:TXPO_0000916c
obo:TXPO_0003392c
obo:TXPO_0002275c
obo:TXPO_0001832c
obo:TXPO_0002352c
obo:TXPO_0002058c
obo:TXPO_0001237c
obo:TXPO_0002345c

hypofunctioningc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000436
Super-classes obo:TXPO_0000434c
Restrictions obo:TXPO_0000716op some obo:BFO_0000015c
Sub-classes obo:TXPO_0001911c
obo:TXPO_0002355c
obo:TXPO_0001910c
obo:TXPO_0001297c
obo:TXPO_0002192c
obo:TXPO_0001957c
obo:TXPO_0005028c
obo:TXPO_0000482c
obo:TXPO_0001340c
obo:TXPO_0000240c
obo:TXPO_0002147c
obo:TXPO_0000438c
obo:TXPO_0002354c
obo:TXPO_0001819c
obo:TXPO_0001963c
obo:TXPO_0004988c
obo:TXPO_0001096c
obo:TXPO_0002356c
obo:TXPO_0001354c
obo:TXPO_0000940c
obo:TXPO_0004066c

arresting functionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000437
Super-classes obo:TXPO_0000434c
Sub-classes obo:GO_0008219c
obo:GO_0019835c

dysfunctioningc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000438
Super-classes obo:TXPO_0000436c
Sub-classes obo:TXPO_0000203c
obo:TXPO_0002436c
obo:TXPO_0001741c
obo:TXPO_0000167c
obo:TXPO_0002361c
obo:TXPO_0004002c
obo:TXPO_0000208c
obo:TXPO_0001433c
obo:TXPO_0002170c
obo:TXPO_0000215c
obo:TXPO_0002221c
obo:TXPO_0002131c
obo:TXPO_0000207c
obo:TXPO_0000751c

loss of function (process)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000439
Super-classes obo:TXPO_0000434c
Sub-classes obo:TXPO_0001438c

negative regulation of phospholipase C mediated phosphatidylinositol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000440
Super-classes obo:TXPO_0001659c
Sub-classes obo:TXPO_0000630c

siftingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000441
Description

Changing medium from medium A to medium B.
Super-classes obo:TXPO_0000261c
Sub-classes obo:TXPO_0000459c
obo:TXPO_0000442c

transmittingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000442
Super-classes obo:TXPO_0000441c
Sub-classes obo:TXPO_0000471c
obo:GO_0006810c

hyperfunction of drug metabolism [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000443
Super-classes obo:TXPO_0002347c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001665c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0000938c
obo:BFO_0000051op some obo:TXPO_0000943c
Sub-classes obo:TXPO_0000106c

caspase signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000444
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002482c
obo:TXPO_0001868op some obo:IMR_0000305c
Sub-classes obo:TXPO_0003104c
obo:TXPO_0000445c
obo:TXPO_0003092c
obo:TXPO_0003103c
obo:TXPO_0002370c
obo:TXPO_0000664c
obo:TXPO_0003091c
obo:TXPO_0000446c

caspase signaling (primitive) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000445
Super-classes obo:TXPO_0000444c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000513c
obo:TXPO_0000774op only obo:TXPO_0002528c

caspase signaling (primitive) [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000446
Super-classes obo:TXPO_0001727c
obo:TXPO_0000444c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000514c
obo:RO_0000057op some obo:TXPO_0000653c

extrinsic (Death Domain) signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000447
Description

This signal triggers the assembly of intracellular proteins to form a death including signaling complex (DISC), which includes a specific intiator procaspase (procaspase-8, 10). These initiator procasapases cleave and converts effector procaspases (i.e., caspase-3, 6, 7) to activate. Then, these effector caspases cleave target proteins, which leads to execute apoptosis.
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0000611c
Sub-classes obo:TXPO_0000448c

extrinsic (Death domain) signaling (primitive) [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000448
Super-classes obo:TXPO_0001727c
obo:TXPO_0000447c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000514c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:RO_0000057op some obo:TXPO_0000653c
obo:TXPO_0002524op some obo:TXPO_0003061c

NRF2 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000449
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002490c
obo:TXPO_0000069op some obo:NCIT_C16407c
obo:TXPO_0000069op some obo:GO_0043066c
Sub-classes obo:TXPO_0000450c
obo:TXPO_0000904c

NRF2 signaling (primitive) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000450
Super-classes obo:TXPO_0000449c
obo:TXPO_0001717c
Restrictions obo:RO_0000057op some obo:TXPO_0000047c
obo:TXPO_0000069op some obo:TXPO_0000371c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000376c

GRP78 - autophagy inducing factor (canonical)[ER stress - autophagy indution]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000451
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000087op some obo:TXPO_0000487c

p53 signaling (primitive) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000452
Super-classes obo:TXPO_0000001c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000445c

p53 signaling (primitive) [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000453
Super-classes obo:TXPO_0000001c
obo:TXPO_0001727c
Restrictions obo:RO_0000057op some obo:TXPO_0000653c
obo:RO_0000057op some obo:TXPO_0000845c
obo:RO_0000057op some obo:TXPO_0000843c
obo:RO_0000057op some obo:TXPO_0000640c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:RO_0000057op some obo:TXPO_0000650c
obo:TXPO_0000069op some obo:TXPO_0002135c

PERK signaling (primitive) [PERK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000454
Super-classes obo:TXPO_0000274c
Restrictions obo:BFO_0000051op some obo:TXPO_0000586c
obo:TXPO_0001868op some obo:TXPO_0001852c
obo:BFO_0000051op some obo:TXPO_0001861c
Sub-classes obo:TXPO_0002742c
obo:TXPO_0000062c

increasing demand for response to oxidative stress [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000455
Super-classes obo:TXPO_0000102c
obo:TXPO_0001730c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000461c
obo:TXPO_0000774op only obo:TXPO_0000677c

retrograde protein transport from ER to cytosol [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000456
Super-classes obo:TXPO_0001717c
obo:GO_0030970c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000516c
obo:TXPO_0000774op only obo:TXPO_0002528c

release of arachidonic acid from cell membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000457
Super-classes obo:TXPO_0002588c
Restrictions obo:BFO_0000066op some obo:GO_0005886c

removing (from A)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000458
Super-classes obo:TXPO_0002577c
Sub-classes obo:GO_0043277c
obo:TXPO_0000631c
obo:TXPO_0004150c
obo:TXPO_0001641c
obo:TXPO_0000619c
obo:GO_0098754c
obo:TXPO_0003396c
obo:TXPO_0000744c

givingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000459
Super-classes obo:TXPO_0000441c
Sub-classes obo:TXPO_0002589c

ER to Golgi transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000460
Super-classes obo:GO_0006810c
Sub-classes obo:TXPO_0002465c

oxidation-antioxidtion inbalance [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000461
Super-classes obo:TXPO_0001730c
obo:TXPO_0002748c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000467c
obo:TXPO_0000774op only obo:TXPO_0000677c

detachingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000462
Super-classes obo:TXPO_0000333c
Sub-classes obo:TXPO_0004016c
obo:TXPO_0001651c
obo:TXPO_0002737c
obo:TXPO_0002492c
obo:TXPO_0000872c

Dissociation of PERK:BIP Heterodimer [ER stress translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000463
Description

PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.
Super-classes obo:TXPO_0002213c
Restrictions obo:RO_0002234op some obo:TXPO_0002839c
obo:TXPO_0000069op some obo:TXPO_0000063c
obo:RO_0002234op some obo:TXPO_0003157c

changing positionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000464
Super-classes obo:TXPO_0000261c
Sub-classes obo:TXPO_0000465c
obo:TXPO_0002586c

changing distancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000465
Super-classes obo:TXPO_0000464c
Sub-classes obo:TXPO_0002580c
obo:TXPO_0000466c
obo:TXPO_0002583c

increasing distancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000466
Super-classes obo:TXPO_0000465c
Sub-classes obo:TXPO_0001617c

increasing free radical [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000467
Super-classes obo:TXPO_0001730c
obo:TXPO_0001790c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000536c
obo:TXPO_0000774op only obo:TXPO_0000677c
obo:TXPO_0000069op some obo:TXPO_0000543c

assemblingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000468
Super-classes obo:TXPO_0002568c
Sub-classes obo:TXPO_0002569c
obo:GO_0022607c
obo:GO_0007005c
obo:TXPO_0002574c
obo:GO_0030198c
obo:TXPO_0000166c
obo:TXPO_0003815c
obo:GO_0034329c
obo:TXPO_0002573c
obo:TXPO_0002575c
obo:TXPO_0002570c
obo:GO_0034389c

joiningc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000469
Super-classes obo:TXPO_0002569c
Sub-classes obo:GO_0005488c

lysosome homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000470
Description

All of the lysosomal enzymes are acid hydrolases, which are active at the acidic pH (about 5) that is maintained within lysosomes but not at the neutral pH (about 7.2) characteristic of the rest of the cytoplasm (Figure 9.35). The requirement of these lysosomal hydrolases for acidic pH provides double protection against uncontrolled digestion of the contents of the cytosol; even if the lysosomal membrane were to break down, the released acid hydrolases would be inactive at the neutral pH of the cytosol.
Super-classes obo:GO_0042592c
Sub-classes obo:TXPO_0000821c

signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000471
Super-classes obo:TXPO_0000442c
Sub-classes obo:GO_0023052c

ground glass appearance dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000472
Super-classes obo:TXPO_0000984c
Sub-classes obo:TXPO_0001004c
obo:TXPO_0001019c
obo:TXPO_0003964c
obo:TXPO_0003923c
obo:TXPO_0003912c
obo:TXPO_0005080c
obo:TXPO_0003971c
obo:TXPO_0000944c
obo:TXPO_0000989c
obo:TXPO_0000999c
obo:TXPO_0003980c
obo:TXPO_0003975c
obo:TXPO_0000975c
obo:TXPO_0003791c
obo:TXPO_0000953c
obo:TXPO_0001797c

hyperfunction of increasing numberc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000473
Super-classes obo:TXPO_0001724c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000093c
Sub-classes obo:TXPO_0002318c

keeping qualityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000474
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0002259c
obo:TXPO_0000213c

changing pressurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000475
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0001689c
obo:TXPO_0001913c

changing temperaturec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000476
Super-classes obo:TXPO_0000415c

insulin signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000477
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0008286c

hyperfunction of long-chain fatty acid import into peroxisomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000478
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:GO_0015910c
Sub-classes obo:TXPO_0000479c

hyperfunction of long-chain fatty acid import into peroxisome [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000479
Super-classes obo:TXPO_0001729c
obo:TXPO_0000478c
Restrictions obo:RO_0000057op some obo:TXPO_0001046c
obo:RO_0000057op some obo:TXPO_0001051c
obo:RO_0000057op some obo:TXPO_0001069c
obo:RO_0000057op some obo:TXPO_0001068c
obo:TXPO_0000069op some obo:TXPO_0000179c
obo:RO_0000057op some obo:TXPO_0001067c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0001057c

hyperfunction of lipid transport to mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000480
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000131c

decreased membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000481
Super-classes obo:PATO_0001462c
(obo:TXPO_0002420c and ub744bL47316C13c)

insufficient functioningc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000482
Super-classes obo:TXPO_0000436c
Sub-classes obo:TXPO_0000580c
obo:TXPO_0002476c
obo:TXPO_0000072c
obo:TXPO_0002474c
obo:TXPO_0002060c
obo:TXPO_0001773c

glutathione depletionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000483
Super-classes obo:TXPO_0000602c
Sub-classes obo:TXPO_0001193c
obo:TXPO_0003569c
obo:TXPO_0002113c

increasing autophagyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000484
Super-classes obo:TXPO_0000344c
Sub-classes obo:TXPO_0000345c

ATP depletionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000485
Super-classes obo:TXPO_0000602c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000207c
obo:TXPO_0000069op some obo:TXPO_0000167c
Sub-classes obo:TXPO_0000486c
obo:TXPO_0001988c

ATP depletion [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000486
Super-classes obo:TXPO_0000485c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000030c
obo:TXPO_0000069op some obo:TXPO_0002387c

autophagy inducerc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000487
Super-classes obo:TXPO_0002629c
Restrictions obo:RO_0002598op some obo:GO_0006914c

accumulation of fluidsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000488
Super-classes obo:TXPO_0000247c
Sub-classes obo:TXPO_0001374c
obo:TXPO_0001216c

in vivo assayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000489
Super-classes obo:OBI_0000070c

ligand molecule [signal transduction system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000490
Super-classes obo:TXPO_0001821c
Restrictions obo:RO_0000056op some obo:TXPO_0001793c
obo:RO_0000087op some obo:TXPO_0000624c

excretory tubec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000491
Super-classes obo:UBERON_0000025c

glycogen accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000492
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_28087c

toxicological imbalance Lc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000493
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL47460C17c and obo:TXPO_0001746c and ub744bL47482C17c)
obo:BFO_0000051op some obo:TXPO_0001735c
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL47460C17c and obo:TXPO_0001746c and ub744bL47482C17c)

hypofunction of ion transport [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000494
Super-classes obo:TXPO_0000495c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

hypofunction of ion transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000495
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:GO_0006811c
Sub-classes obo:TXPO_0000494c
obo:TXPO_0002034c

hypofunction of phospholipid degradation by PLA1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000496
Super-classes obo:TXPO_0000914c
Restrictions obo:RO_0000057op some obo:TXPO_0000500c
obo:RO_0000057op some obo:TXPO_0000499c
obo:TXPO_0001868op some obo:TXPO_0001803c

hypofunction of phospholipid degradation by phospholipase A2 [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000497
Super-classes obo:TXPO_0000914c
Restrictions obo:RO_0000057op some obo:TXPO_0000500c
obo:TXPO_0001868op some obo:TXPO_0001804c
obo:RO_0000057op some obo:TXPO_0000499c

hypofunction of phospholipid degradation by phospholipase C [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000498
Super-classes obo:TXPO_0000914c
Restrictions obo:RO_0000057op some obo:TXPO_0000499c
obo:RO_0000057op some obo:TXPO_0000500c
obo:TXPO_0001868op some obo:TXPO_0001805c

chloropromazine・CAD [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000499
Super-classes obo:CHEBI_3647c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0001426c

chloroquine [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000500
Super-classes obo:TXPO_1000418c
obo:TXPO_0001849c

glutathione depletion [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000501
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0000655c
obo:BFO_0000051op some obo:TXPO_0001183c
obo:BFO_0000051op some obo:TXPO_0003173c
obo:BFO_0000051op some obo:TXPO_0003168c
obo:BFO_0000051op some obo:TXPO_0003177c
obo:BFO_0000051op some obo:TXPO_0003209c
obo:BFO_0000051op some obo:TXPO_0003183c
obo:BFO_0000051op some obo:TXPO_0001193c
obo:TXPO_0000004op only obo:TXPO_0001193c
obo:BFO_0000051op some obo:TXPO_0001205c
obo:BFO_0000051op some obo:TXPO_0001204c
obo:BFO_0000051op some obo:TXPO_0001199c
obo:BFO_0000051op some obo:TXPO_0002370c
obo:BFO_0000051op some obo:TXPO_0001184c
obo:BFO_0000051op some obo:TXPO_0002368c
obo:BFO_0000051op some obo:TXPO_0003174c
obo:BFO_0000051op some obo:TXPO_0003288c
obo:BFO_0000051op some obo:TXPO_0003180c
obo:BFO_0000051op some obo:TXPO_0002734c
obo:BFO_0000051op some obo:TXPO_0002363c
obo:BFO_0000051op some obo:TXPO_0003186c
obo:BFO_0000051op some obo:TXPO_0002366c
obo:BFO_0000051op some obo:TXPO_0002376c
obo:BFO_0000051op some obo:TXPO_0001944c
obo:BFO_0000051op some obo:TXPO_0001180c
obo:BFO_0000051op some obo:TXPO_0002373c
obo:BFO_0000051op some obo:TXPO_0002759c
obo:BFO_0000051op some obo:TXPO_0001198c
obo:BFO_0000051op some obo:TXPO_0002375c
obo:BFO_0000051op some obo:TXPO_0001933c
obo:BFO_0000051op some obo:TXPO_0000844c
obo:BFO_0000051op some obo:TXPO_0002711c
obo:BFO_0000051op some obo:TXPO_0001187c
obo:BFO_0000051op some obo:TXPO_0002372c
obo:BFO_0000051op some obo:TXPO_0001178c
obo:BFO_0000051op some obo:TXPO_0002733c
obo:BFO_0000051op some obo:TXPO_0002404c
obo:BFO_0000051op some obo:TXPO_0003189c
obo:BFO_0000051op some obo:TXPO_0001196c
obo:BFO_0000051op some obo:TXPO_0000904c
obo:BFO_0000051op some obo:TXPO_0001191c
obo:BFO_0000051op some obo:TXPO_0002371c
obo:BFO_0000051op some obo:TXPO_0002430c
obo:BFO_0000051op some obo:TXPO_0001203c
obo:BFO_0000051op some obo:TXPO_0001190c
obo:BFO_0000051op some obo:TXPO_0001201c
obo:BFO_0000051op some obo:TXPO_0001192c
obo:BFO_0000051op some obo:TXPO_0002379c
obo:BFO_0000051op some obo:TXPO_0001197c
obo:BFO_0000051op some obo:TXPO_0002407c
obo:BFO_0000051op some obo:TXPO_0002367c
obo:BFO_0000051op some obo:TXPO_0001202c
obo:BFO_0000051op some obo:TXPO_0002369c
obo:BFO_0000051op some obo:TXPO_0003208c
obo:BFO_0000051op some obo:TXPO_0001181c
obo:BFO_0000051op some obo:TXPO_0001182c
obo:BFO_0000051op some obo:TXPO_0002613c
obo:BFO_0000051op some obo:TXPO_0003178c
obo:BFO_0000051op some obo:TXPO_0003185c
obo:BFO_0000051op some obo:TXPO_0003175c
obo:BFO_0000051op some obo:TXPO_0001200c
obo:BFO_0000051op some obo:TXPO_0001920c
obo:BFO_0000051op some obo:TXPO_0001149c
obo:BFO_0000051op some obo:TXPO_0001194c
obo:BFO_0000051op some obo:TXPO_0001207c
obo:BFO_0000051op some obo:TXPO_0001179c
obo:BFO_0000051op some obo:TXPO_0001206c
obo:BFO_0000051op some obo:TXPO_0002254c
obo:BFO_0000051op some obo:TXPO_0001185c
obo:BFO_0000051op some obo:TXPO_0000675c

CASPASE (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000502
Super-classes obo:IMR_0000305c
obo:TXPO_0000871c
obo:TXPO_1000414c
Restrictions obo:TXPO_0002260op some obo:IMR_0000305c
Sub-classes obo:TXPO_0001282c

hyperfunction of alcohol metabolism [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000503
Super-classes obo:TXPO_0001272c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001288c
obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0001408c

malfunctioning of regulation of gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000504
Super-classes obo:TXPO_0000532c
Restrictions obo:TXPO_0001518op some obo:GO_0010468c

dissociation of BIP complex [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000505
Super-classes obo:TXPO_0000872c
Restrictions obo:BFO_0000066op some obo:GO_0005789c
obo:TXPO_0001868op some obo:TXPO_0002106c
obo:RO_0002234op some obo:TXPO_0002385c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002903c
obo:TXPO_0002176c
obo:TXPO_0002213c

canalicular bile acid transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000506
Description

related molecular function GO:0015126
Super-classes obo:TXPO_0003703c

activation of thioredoxin pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000507
Super-classes obo:TXPO_0000401c
Sub-classes obo:TXPO_0002367c

decreasing amount of abnormal proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000508
Super-classes obo:TXPO_0000396c

bile acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000509
Super-classes obo:CHEBI_35341c
Sub-classes obo:CHEBI_28834c
obo:CHEBI_9907c
obo:CHEBI_16325c
obo:CHEBI_16755c
obo:CHEBI_16359c

anoikis [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000512
Super-classes obo:TXPO_0000008c
obo:GO_0043276c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

apoptotic process [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000513
Super-classes obo:TXPO_0001717c
obo:GO_0006915c
Restrictions obo:TXPO_0002524op some obo:TXPO_0003102c
obo:BFO_0000051op some obo:TXPO_0003110c
obo:TXPO_0000069op some obo:TXPO_0000342c
obo:BFO_0000051op some obo:TXPO_0003107c
obo:BFO_0000051op some obo:TXPO_0003105c
obo:BFO_0000051op some obo:TXPO_0003091c
obo:BFO_0000051op some obo:TXPO_0003109c
obo:BFO_0000051op some obo:TXPO_0003104c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0003103c
obo:BFO_0000051op some obo:TXPO_0002948c
obo:BFO_0000051op some obo:TXPO_0003092c
obo:BFO_0000051op some obo:TXPO_0003113c

apoptotic process [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000514
Super-classes obo:TXPO_0000008c
obo:GO_0006915c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002128c
obo:BFO_0000051op some obo:TXPO_0002388c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002125c
obo:BFO_0000051op some obo:TXPO_0000231c

apoptotic process [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000515
Super-classes obo:TXPO_0001730c
obo:GO_0006915c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c
obo:TXPO_0000069op some obo:TXPO_0002333c

protein catabolic process [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000516
Super-classes obo:GO_0030163c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002479c
obo:TXPO_0000774op only obo:TXPO_0002528c

increasing demand for response to oxidative stress [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000517
Super-classes obo:TXPO_0001717c
obo:TXPO_0000102c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002747c
obo:TXPO_0000774op only obo:TXPO_0002528c

GDF15 (human)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000518
Super-classes obo:TXPO_0000840c
obo:TXPO_1000164c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009518c
obo:TXPO_0000756op some ncicp:C15958c

oxidoreductasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000519
Description

related molecular function GO:0016491
Super-classes obo:TXPO_0003660c
Sub-classes obo:TXPO_0003328c
obo:TXPO_0003887c

classification of cell death by distributionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000520
Description

Zone 3 hepatocytes are rich in P450, which produce drug metabolites to cause cell death.
Super-classes obo:GO_0008219c
Sub-classes obo:TXPO_0000522c
obo:TXPO_0000521c
obo:TXPO_0000523c
obo:TXPO_0000148c

centrilobular necrosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000521
Super-classes obo:TXPO_0000520c

periportal necrosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000522
Super-classes obo:TXPO_0000520c

zonal necrosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000523
Super-classes obo:TXPO_0000520c

expanding inflammationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000524
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0000525c

expanding inflammation [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000525
Super-classes obo:TXPO_0000524c

leaking content from cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000526
Super-classes obo:TXPO_0001699c
Sub-classes obo:TXPO_0003739c
obo:TXPO_0000527c
obo:TXPO_0000862c
obo:TXPO_0000555c

leaking content from cell [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000527
Super-classes obo:TXPO_0000526c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000541c
obo:TXPO_0000774op only obo:TXPO_0000323c

NAPQI productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000528
Super-classes obo:TXPO_0000019c
Sub-classes obo:TXPO_0001184c

ASAH1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000529
Super-classes obo:TXPO_1000009c
obo:TXPO_0002668c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000427c
obo:RO_0000087op some obo:TXPO_0003321c
obo:TXPO_0000756op some obo:TXPO_0001442c
Sub-classes obo:TXPO_0003350c
obo:TXPO_0003602c
obo:TXPO_0003456c
obo:TXPO_0001395c

malfunctioning of controllingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000532
Super-classes obo:TXPO_0000434c
Sub-classes obo:TXPO_0000504c
obo:TXPO_0005018c
obo:TXPO_0000235c
obo:TXPO_0002092c
obo:TXPO_0004997c

cell repairc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000533
Super-classes obo:TXPO_0000535c
Restrictions obo:BFO_0000051op some obo:TXPO_0000620c
Sub-classes obo:TXPO_0000534c

cell repair [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000534
Super-classes obo:TXPO_0000533c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

repairingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000535
Super-classes obo:TXPO_0000392c
Restrictions obo:BFO_0000051op some obo:TXPO_0000619c
Sub-classes obo:GO_0030091c
obo:GO_0042245c
obo:GO_0006281c
obo:TXPO_0000533c

JNK signaling (primitive) [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000536
Super-classes obo:TXPO_0001730c
obo:TXPO_0000769c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c
obo:TXPO_0000069op some obo:TXPO_0001186c

extracellular matrix excess depositionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000537
Super-classes obo:TXPO_0000247c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000219c
obo:RO_0002233op some obo:GO_0031012c

process on structural viewpointc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000538
Super-classes obo:TXPO_0000420c
Sub-classes obo:TXPO_0003719c
obo:TXPO_0003718c
obo:TXPO_0000886c

necrosis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000539
Super-classes obo:GO_0070265c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000927c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0000555c

inflammatory cell infiltrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000540
Super-classes obo:TXPO_0002587c
Restrictions obo:RO_0002233op some (obo:CL_0000000c and ub744bL48334C17c)
Sub-classes obo:TXPO_0003740c
obo:TXPO_0003622c
obo:TXPO_0000156c
obo:TXPO_0003831c
obo:TXPO_0003990c
obo:TXPO_0000541c

inflammatory cell infiltration [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000541
Super-classes obo:TXPO_0001727c
obo:TXPO_0000540c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002142c

abnormality of membrane [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000542
Super-classes obo:TXPO_0001730c
obo:TXPO_0001755c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000546c
obo:TXPO_0000774op only obo:TXPO_0000677c
obo:TXPO_0000069op some obo:TXPO_0000566c

lipoperoxidation [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000543
Super-classes obo:TXPO_0003514c
obo:TXPO_0001730c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000042c
obo:TXPO_0000069op some obo:TXPO_0000542c
obo:TXPO_0000774op only obo:TXPO_0000677c

changing areac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000544
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000242c
obo:TXPO_0000140c

increasing cell volume [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000545
Description

Toxicant induced cholestasis is associated with cell swelling, cell death, and inflammation
Super-classes obo:TXPO_0000034c
obo:TXPO_0000142c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

positive regulation of mitochondrial membrane permeability [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000546
Super-classes obo:TXPO_0001730c
obo:GO_0035794c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c
obo:TXPO_0000069op some obo:TXPO_0000515c

SLC10A1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000547
Description

The sodium dependent uptake of bile salts is mediated by the NTCP (sodium/bile acid cotransporter; SLC10A1), which is expressed in a polar manner at the basolateral plasma membrane of hepatocytes. NTCP has a preference for conjugated bile salts.
Super-classes obo:TXPO_0000276c
obo:TXPO_1000338c
Restrictions obo:RO_0000087op some obo:TXPO_0003704c

negative regulation of cell cyclec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000548
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0007049c
Sub-classes obo:TXPO_0000370c

Phosphorylation of eIF2-alpha by PERKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000549
Super-classes obo:TXPO_0001899c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001792c
Sub-classes obo:TXPO_0000700c

causec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000550
Super-classes obo:TXPO_0000553c

resultc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000551
Super-classes obo:TXPO_0000554c

changing lengthc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000552
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000141c
obo:TXPO_0000244c

upstreamc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000553
Super-classes obo:TXPO_0001299c
Sub-classes obo:TXPO_0000550c

downstreamc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000554
Super-classes obo:TXPO_0001299c
Sub-classes obo:TXPO_0000551c

leaking content from cell [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000555
Super-classes obo:TXPO_0001716c
obo:TXPO_0000526c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004113c
obo:TXPO_0000774op only obo:TXPO_0003382c

negative regulation of phospholipase C mediated phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000556
Super-classes obo:TXPO_0001256c
Sub-classes obo:TXPO_0000647c

transport signal sorting of NPC1 / NPC2c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000557
Super-classes obo:TXPO_0001534c

positive regulation of macrophage derived foam cell differentiation [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000558
Super-classes obo:TXPO_0004085c
Restrictions obo:RO_0000057op some obo:TXPO_0000077c
obo:RO_0000057op some obo:TXPO_0004086c
obo:TXPO_0000069op some obo:TXPO_0004154c
obo:TXPO_0000774op only obo:TXPO_0002215c

phospholipase inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000559
Super-classes obo:CHEBI_76759c
Sub-classes obo:CHEBI_76811c
obo:TXPO_0000562c
obo:TXPO_0003220c

ground glass appearance dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000560
Super-classes obo:TXPO_0000984c
Sub-classes obo:TXPO_0003910c
obo:TXPO_0001524c

HYOU1 - chaperone -vitro (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000561
Super-classes obo:TXPO_0000800c
Restrictions obo:RO_0000087op only obo:TXPO_0003997c
obo:TXPO_0000756op some obo:TXPO_0000795c

phospholipase C inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000562
Super-classes obo:TXPO_0000559c

G6PC (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000563
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002538c
Sub-classes obo:TXPO_0001797c

signalling molecule rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000564
Super-classes obo:CHEBI_33280c
Sub-classes obo:TXPO_0003657c

peroxidasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000565
Description

related molecular function GO:0004601
Super-classes obo:TXPO_0003660c
Restrictions obo:RO_0000087op some obo:CHEBI_22586c

calcium ion homeostasis imbalance [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000566
Super-classes obo:TXPO_0001730c
obo:TXPO_0001765c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000814c
obo:TXPO_0000774op only obo:TXPO_0000677c

imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000567
Super-classes obo:TXPO_0001847c
Restrictions obo:TXPO_0001733op only obo:TXPO_0003992c
Sub-classes obo:TXPO_0002748c
obo:TXPO_0002302c
obo:TXPO_0002478c
obo:TXPO_0001661c
obo:TXPO_0003801c
obo:TXPO_0000418c
obo:TXPO_0002308c
obo:TXPO_0000572c
obo:TXPO_0002530c
obo:TXPO_0002653c
obo:TXPO_0002459c
obo:TXPO_0002336c
obo:TXPO_0003546c
obo:TXPO_0000568c
obo:TXPO_0000570c

homeostasis imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000568
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0003553c
obo:TXPO_0001656c

endoplasmic reticulum stress response imbalance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000569
Super-classes obo:TXPO_0001717c
obo:TXPO_0000571c
Restrictions obo:BFO_0000051op some obo:TXPO_0002458c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002460c
obo:BFO_0000051op some obo:TXPO_0002479c
obo:BFO_0000051op some obo:TXPO_0002747c
obo:TXPO_0000069op some obo:TXPO_0000752c

stress response imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000570
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0000571c

endoplasmic reticulum stress response imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000571
Super-classes obo:TXPO_0000570c
Sub-classes obo:TXPO_0000569c

protein quality control imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000572
Super-classes obo:TXPO_0000567c

increasing demand for response to ER stress [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000573
Super-classes obo:TXPO_0001727c
obo:TXPO_0000362c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000453c
obo:RO_0000057op some obo:TXPO_0000640c
obo:TXPO_0000774op only obo:TXPO_0000323c

increasing demand for response to oxidative stress [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000574
Super-classes obo:TXPO_0000102c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:RO_0000057op some obo:TXPO_0000645c
obo:TXPO_0000069op some obo:TXPO_0000234c
obo:TXPO_0000069op some obo:TXPO_0002381c
obo:RO_0000057op some obo:TXPO_0000641c
obo:RO_0000057op some obo:TXPO_0000642c

bile acid and bile salt transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000575
Super-classes obo:TXPO_0003703c

metabolic intermediate accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000576
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some (obo:BFO_0000040c and ub744bL48748C17c)
Sub-classes obo:TXPO_0003520c

decreasing pHc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000577
Super-classes obo:TXPO_0001520c
Sub-classes obo:TXPO_0000578c

decreasing cellular pHc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000578
Super-classes obo:TXPO_0000577c
Sub-classes obo:TXPO_0000579c

decreasing cellular pH [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000579
Super-classes obo:TXPO_0000578c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

ischemiac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000580
Super-classes obo:TXPO_0000482c
Sub-classes obo:TXPO_0000582c
obo:TXPO_0000732c

ANGPTL4 (human)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000581
Super-classes obo:TXPO_1000002c
obo:TXPO_0000840c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000051129c

ischemia [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000582
Super-classes obo:TXPO_0000580c
obo:TXPO_0001727c
Restrictions obo:RO_0000057op some obo:TXPO_0000645c
obo:TXPO_0000069op some obo:TXPO_0000226c
obo:TXPO_0000774op only obo:TXPO_0000323c

ATF6 (ATF6-alpha) activates chaperone genesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000583
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0001306c

regulation of Cxcl2 expression by TNF-alphac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000584
Description

CXCL1 is one of the members of chemokines, which are small heparin-binding proteins that generally direct the movement of circulating leukocytes to sites of inflammation or injury.

TNF-α stimulates CXCL1 release from human ECs through JNK-mediated CXCL1 mRNA expression and p38 MAPK- and PI-3K-mediated CXCL1 secretory processes.
Super-classes obo:TXPO_0000585c

regulation of gene expression by TNF-alphac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000585
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0000584c

PERK activation [PERK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000586
Super-classes obo:TXPO_0000357c
Restrictions obo:TXPO_0000012op some obo:TXPO_0000712c
obo:TXPO_0001868op some obo:TXPO_0001852c
obo:TXPO_0000012op some obo:TXPO_0000742c
Sub-classes obo:TXPO_0000402c

SCD (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000587
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003329c
obo:TXPO_0000819op some obo:OGG_3000006319c
Sub-classes obo:TXPO_0003327c
obo:TXPO_0001301c

change in H+ ion concentrationsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000588
Super-classes obo:TXPO_0002438c

changing weightc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000589
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000040c

bile refluxc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000590
Super-classes obo:TXPO_0003122c
Sub-classes obo:TXPO_0002664c

polyphenolc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000591
Super-classes obo:CHEBI_33853c
Sub-classes obo:CHEBI_27881c

oxidative stress dependent molecule (human in vivo)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000592
Super-classes obo:TXPO_0000297c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
obo:TXPO_0000756op some ncicp:C15958c

CCL4_ [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000593
Super-classes obo:TXPO_0003509c
Restrictions obo:RO_0000087op some obo:TXPO_0000598c
obo:RO_0000087op some obo:CHEBI_59739c

oxidative stress dependent molecule (caonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000594
Super-classes obo:TXPO_0000297c

CCL4 -necrosis inducer [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000595
Super-classes obo:TXPO_0003509c
Restrictions obo:RO_0000087op some obo:TXPO_0002397c

oxidative stress dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000596
Super-classes obo:TXPO_0000297c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0003360op some obo:NCBITaxon_10114c

hyperfunction of cell survival [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000597
Super-classes obo:TXPO_0002275c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0002322c
obo:BFO_0000051op some obo:TXPO_0000954c
obo:BFO_0000051op some obo:TXPO_0002320c
obo:BFO_0000051op some obo:TXPO_0002319c
obo:TXPO_0000069op some obo:TXPO_0003597c

lipoperoxidator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000598
Super-classes obo:TXPO_0003712c

Plc gamma1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000599
Super-classes obo:TXPO_0000985c
obo:IMR_0000732c
Restrictions obo:TXPO_0002260op some obo:IMR_0000284c
obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0000756op some ncicp:C15958c

meta-functioning processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000600
Description

For example, the 'to vaporize' function of the boiler is to perform a meta-function to enable for the 'to rotate' function of the turbine. The meta-functions are result of teleological interpretation of causal relations among base-functions of different components (i.e., inter-components relations).
Super-classes obo:TXPO_0000145c
Sub-classes obo:TXPO_0001754c
obo:TXPO_0003112c
obo:TXPO_0001756c
obo:TXPO_0002541c
obo:TXPO_0001753c
obo:TXPO_0001757c

storingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000601
Super-classes obo:TXPO_0000379c
Restrictions obo:TXPO_0000531op some obo:PATO_0002269c
Sub-classes obo:TXPO_0000247c

depletingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000602
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0000485c
obo:TXPO_0000673c
obo:TXPO_0000483c

pathway systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000603
Super-classes obo:BFO_0000027c
Sub-classes obo:TXPO_0000887c
obo:TXPO_0001513c
obo:TXPO_0000634c

CREB3L3 signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000604
Super-classes obo:GO_0023052c
Sub-classes obo:TXPO_0003081c

hypofunction of ATP biosynthesis [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000605
Super-classes obo:TXPO_0001730c
obo:TXPO_0001722c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c

transferasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000606
Description

related molecular function GO:0016740
Super-classes obo:TXPO_0003660c
Sub-classes obo:TXPO_0001385c
obo:TXPO_0001021c
obo:TXPO_0001515c
obo:TXPO_0002306c
obo:TXPO_0001027c

maintaining mitochondrial membrane permeabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000607
Super-classes obo:TXPO_0000133c

process sequencec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000608
Super-classes obo:BFO_0000015c
Restrictions obo:BFO_0000051op some obo:BFO_0000015c
Sub-classes obo:NCIT_C54214c
obo:TXPO_0003763c
obo:OGMS_0000063c
obo:TXPO_0000009c

signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000609
Description
  1. signal detection (acceptance), 2. signal transduction, 3. gene regulation (genetic information conversion process), 4. celllular process execution This entity covers from 1 to 2.
Super-classes obo:NCIT_C54214c
Restrictions obo:TXPO_0002525op some obo:TXPO_0000027c
obo:BFO_0000051op some obo:GO_0023052c
obo:BFO_0000051op some obo:TXPO_0002174c
Sub-classes obo:TXPO_0004530c
obo:GO_0036337c
obo:TXPO_0004846c
obo:TXPO_0004628c
obo:TXPO_0004553c
obo:TXPO_0004694c
obo:TXPO_0004494c
obo:TXPO_0004870c
obo:TXPO_0004302c
obo:TXPO_0004838c
obo:TXPO_0004635c
obo:TXPO_0004859c
obo:GO_0031929c
obo:TXPO_0002126c
obo:TXPO_0004823c
obo:GO_0007219c
obo:TXPO_0004544c
obo:TXPO_0004805c
obo:GO_0070498c
obo:TXPO_0004867c
obo:TXPO_0000285c
obo:GO_0031098c
obo:TXPO_0005064c
obo:GO_0038110c
obo:TXPO_0004811c
obo:TXPO_0004662c
obo:GO_0002224c
obo:TXPO_0002155c
obo:GO_0048012c
obo:GO_0043491c
obo:TXPO_0004534c
obo:TXPO_0004575c
obo:GO_0070102c
obo:TXPO_0004751c
obo:GO_0033209c
obo:GO_0007173c
obo:TXPO_0004806c
obo:TXPO_0002481c
obo:GO_0038151c
obo:TXPO_0004666c
obo:TXPO_0004423c
obo:TXPO_0004813c
obo:TXPO_0000611c
obo:TXPO_0004540c
obo:GO_0097193c
obo:TXPO_0004484c
obo:GO_0007179c
obo:TXPO_0002482c

metabolic pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000610
Super-classes obo:NCIT_C54214c
Sub-classes obo:TXPO_0000652c
obo:HINO_0016374c

death domain signanaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000611
Super-classes obo:TXPO_0000609c
Sub-classes obo:GO_0008625c

nodule formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000612
Description

GO:0009877 nodule morphogenesis is part of some nodulation. However, nodulation is defined as the formation of nitrogen-fixing root nodules on plant roots. Therefore, TXPO does not reuse GO terms and defines originally.
Super-classes obo:TXPO_0000134c
Sub-classes obo:TXPO_0005036c
obo:TXPO_0003783c

GPC3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000613
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004068c

data itemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000614
Super-classes obo:IAO_0000030c
Sub-classes obo:OBI_0302867c
obo:TXPO_0001503c
obo:OGMS_0000073c
obo:IAO_0000109c

increasing volume of liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000616
Super-classes obo:TXPO_0000139c
Restrictions obo:RO_0002234op some (obo:UBERON_0002107c and ub744bL49163C17c)
Sub-classes obo:TXPO_0000973c
obo:TXPO_0002538c

polypeptidec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000617
Super-classes obo:CHEBI_16670c

increase of ROS and RNS productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000618
Super-classes obo:TXPO_0000395c

removing damaged objectc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000619
Super-classes obo:TXPO_0000458c
Sub-classes obo:TXPO_0004499c
obo:TXPO_0000627c
obo:TXPO_0000620c

removing damaged organellec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000620
Super-classes obo:TXPO_0000619c

negative regulation of phospholipase C mediated phosphatidylcholine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000621
Super-classes obo:GO_0010900c
Sub-classes obo:TXPO_0000646c

cytokinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000622
Description

related molecular function GO:0005125
Super-classes obo:CHEBI_33280c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
Sub-classes obo:TXPO_0000155c

regulator role of receivingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000623
Description

related molecular function GO:0030545
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:TXPO_0000379c
Sub-classes obo:TXPO_0000624c

ligandc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000624
Description

related molecular function GO:0005102
Super-classes obo:TXPO_0000623c
Restrictions obo:TXPO_0000178op some obo:TXPO_0001793c

role related to increasing numberc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000625
Super-classes obo:TXPO_0003712c
Sub-classes obo:TXPO_0002350c
obo:TXPO_0000626c

DNA replication factor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000626
Super-classes obo:TXPO_0000625c
Restrictions obo:TXPO_0000178op some obo:GO_0006260c

removing damaged cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000627
Super-classes obo:TXPO_0000619c

negative regulation of phopholipase C mediated phosphatidyliserine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000628
Super-classes obo:TXPO_0001650c
Sub-classes obo:TXPO_0000637c

negative regulation of phopholipase C mediated phosphatidylinositol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000629
Super-classes obo:TXPO_0001659c

negative regulation of phospholipase C mediated phosphatidylinositol degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000630
Super-classes obo:TXPO_0000647c
obo:TXPO_0000440c

xenobiotics excretionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000631
Super-classes obo:TXPO_0000458c
Sub-classes obo:TXPO_0002077c

increasinging length of timec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000632
Super-classes obo:TXPO_0001505c

increasing functional demandc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000633
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0000361c
obo:TXPO_0001248c
obo:TXPO_0002471c
obo:TXPO_0002444c
obo:TXPO_0000848c
obo:TXPO_0000180c
obo:TXPO_0002211c
obo:TXPO_0000789c
obo:TXPO_0003176c
obo:TXPO_0000747c

signal transduction systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000634
Super-classes obo:TXPO_0000603c
Restrictions obo:RO_0002351op some obo:TXPO_0001833c
obo:RO_0002351op some obo:TXPO_0001828c
obo:TXPO_0001896op some obo:GO_0023052c
obo:RO_0002351op some obo:TXPO_0000490c
Sub-classes obo:TXPO_0001732c
obo:TXPO_0001696c

Phospholipase familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000635
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000120c
obo:TXPO_0001303c
obo:IMR_0000287c
obo:IMR_0000283c
obo:IMR_0000284c

hyperfunction of Kupffer cell differentiation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000636
Super-classes obo:TXPO_0003434c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0000334c

negative regulation of phopholipase C mediated phosphatidyliserine degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000637
Super-classes obo:TXPO_0000647c
obo:TXPO_0000628c
Restrictions obo:RO_0000057op only obo:TXPO_0001425c

role related to decreasing amountc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000638
Super-classes obo:TXPO_0003712c
Sub-classes obo:TXPO_0002044c
obo:CHEBI_68509c

inflammatory cytokine gene expression [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000639
Super-classes obo:TXPO_0002266c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

Eif2s1 (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000640
Super-classes obo:TXPO_1000132c
obo:TXPO_0000839c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:CHEBI_68495c
obo:RO_0000087op some obo:TXPO_0003685c

Osgin1 (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000641
Super-classes obo:TXPO_0000839c
obo:TXPO_1000272c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
Sub-classes obo:TXPO_0003215c
obo:TXPO_0003216c
obo:TXPO_0003214c

Txrnd1 (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000642
Super-classes obo:TXPO_0000839c
obo:TXPO_1000390c
Restrictions obo:RO_0000087op some obo:CHEBI_22586c
obo:TXPO_0000756op some ncicp:C15958c

inreasing blood AST concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000643
Super-classes obo:TXPO_0000352c
Restrictions obo:RO_0002234op some (obo:TXPO_0001014c and ub744bL49420C17c)
Sub-classes obo:TXPO_0000861c

decreasing lipidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000644
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0001056c
obo:TXPO_0003963c
obo:TXPO_0003601c
obo:TXPO_0002084c

Hmox1 (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000645
Super-classes obo:TXPO_0000839c
obo:TXPO_1000196c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

negative regulation of phospholipase C mediated phosphatidylcholine degradation [Phospholipidosis - phosphatidylcholine disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000646
Super-classes obo:TXPO_0000621c
obo:TXPO_0000647c
Restrictions obo:RO_0000057op only obo:TXPO_0001425c

negative regulation of phospholipase C mediated phospholipid degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000647
Super-classes obo:TXPO_0000556c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0000637c
obo:TXPO_0000630c
obo:TXPO_0000646c

eosinogranular degeneration dependent molecule (mice)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000648
Super-classes obo:TXPO_0000835c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10090c
Sub-classes obo:TXPO_0001057c
obo:TXPO_0003248c
obo:TXPO_0001055c
obo:TXPO_0003242c
obo:TXPO_0003238c
obo:TXPO_0003243c
obo:TXPO_0000846c
obo:TXPO_0003250c
obo:TXPO_0002017c
obo:TXPO_0000870c
obo:TXPO_0003247c
obo:TXPO_0001058c
obo:TXPO_0003245c
obo:TXPO_0001045c

ACOT12 metastasis inhibitor (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000649
Super-classes obo:TXPO_0001034c
obo:TXPO_1000021c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

Nifib (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000650
Super-classes obo:TXPO_0000839c
obo:TXPO_1000260c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:TXPO_0000329c

pathogen colonizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000651
Super-classes obo:TXPO_0001851c

glutathione biosynthetic pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000652
Super-classes obo:TXPO_0000610c

JUN (canonical)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000653
Super-classes obo:TXPO_0003195c
obo:IMR_0000416c

AKR7A3 (human)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000654
Super-classes obo:TXPO_0001916c
obo:TXPO_1000033c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000022977c

hyperfunction of antioxidant gene expression [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000655
Super-classes obo:TXPO_0000658c
obo:TXPO_0000889c
Restrictions obo:BFO_0000051op some obo:TXPO_0002216c
obo:TXPO_0000069op some obo:TXPO_0001194c
obo:BFO_0000051op some obo:TXPO_0000904c
obo:BFO_0000051op some obo:TXPO_0000656c
obo:TXPO_0000774op only obo:TXPO_0000501c

antioxidant gene expression [Gutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000656
Super-classes obo:TXPO_0000889c
obo:TXPO_0002061c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0000655c
obo:RO_0000057op some obo:TXPO_0000654c
obo:TXPO_0001868op some obo:TXPO_0000855c
obo:RO_0000057op some obo:TXPO_0001934c

predicted (quality)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000657
Super-classes obo:BFO_0000019c

hyperfunction of antioxidant gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000658
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0000655c

MMAA (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000659
Super-classes obo:TXPO_0003833c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000166785c
obo:RO_0000086op some obo:TXPO_0000657c

changing protein structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000660
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0002565c
obo:TXPO_0001956c

ECM2 (predicted)(human)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000661
Description

predicted gene by Support Vector Machine (SVM) using human primary hepatocyte
Super-classes obo:TXPO_0000665c
obo:TXPO_0001916c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000001842c
Sub-classes obo:TXPO_0000079c

cytoplasmic alternation [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000662
Description

Changes in cytoplasm in the hepatocytes. Liver is responsible for drug metabolism; therefore these findings are most frequently observed results in drug safety studies. It shows various morphological images depending on the kind of chemical substance.
Super-classes obo:TXPO_0001507c
Restrictions obo:TXPO_0003500op some obo:GO_0005737c
Sub-classes obo:TXPO_0000060c
obo:TXPO_0003515c

ALDOB (predicted)(human)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000663
Description

predicted gene by Support Vector Machine (SVM) using human primary hepatocyte
Super-classes obo:TXPO_0000666c
obo:TXPO_0001916c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000000229c
obo:RO_0000087op some obo:TXPO_0000676c

caspase signaling (primitive) [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000664
Super-classes obo:TXPO_0001716c
obo:TXPO_0000444c
Restrictions obo:RO_0000057op some obo:TXPO_0003226c
obo:RO_0000057op some obo:TXPO_0003225c
obo:RO_0000057op some obo:TXPO_0003272c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003273c

ECM2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000665
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001842c
Sub-classes obo:TXPO_0000661c
obo:TXPO_0000079c

ALDOB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000666
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000229c
Sub-classes obo:TXPO_0000663c

regulation of gene expression [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000667
Super-classes obo:TXPO_0001727c
obo:GO_0010468c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

oxidative stress responsive factor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000668
Description

related process GO:0006979 response to oxidative stress
Super-classes obo:TXPO_0003730c

cell cycle G1/S phase transition [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000669
Super-classes obo:TXPO_0001728c
obo:GO_0044843c
Restrictions obo:RO_0000057op some obo:TXPO_0001003c
obo:TXPO_0000069op some obo:TXPO_0000962c
obo:TXPO_0000774op only obo:TXPO_0001432c

ethanol [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000670
Super-classes obo:TXPO_0003508c

decreasing concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000671
Super-classes obo:TXPO_0002438c
Restrictions obo:TXPO_0000531op some obo:PATO_0001163c
Sub-classes obo:TXPO_0002439c
obo:TXPO_0001332c
obo:TXPO_0001330c
obo:MP_0005039c
obo:TXPO_0001362c

gene expression by estrogen receptorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000672
Super-classes obo:TXPO_0000375c

starvationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000673
Super-classes obo:TXPO_0000602c
Sub-classes obo:TXPO_0000733c

PERK autophosphorylation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000674
Super-classes obo:TXPO_0003736c
obo:TXPO_0000742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0000878c
Sub-classes obo:TXPO_0002869c
obo:TXPO_0002997c
obo:TXPO_0000388c
obo:TXPO_0002868c
obo:TXPO_0002870c

negative regulation of glycolytic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000675
Super-classes obo:GO_0045820c
obo:TXPO_0000889c
Restrictions obo:RO_0000057op some obo:TXPO_0001919c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0000663c
obo:TXPO_0000069op some obo:TXPO_0002379c

fructose-1-phosphate aldolasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000676
Super-classes obo:TXPO_0000804c

oxidative stress [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000677
Description

Generation of free radicals or depletion of free radical scavengers and other antioxidant defences such as glutathione -> generation of reactive oxyen metabolites ->damaging effects on cell
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0000461c
obo:BFO_0000051op some obo:TXPO_0000815c
obo:BFO_0000051op some obo:TXPO_0000515c
obo:BFO_0000051op some obo:TXPO_0002333c
obo:BFO_0000051op some obo:TXPO_0000814c
obo:BFO_0000051op some obo:TXPO_0000042c
obo:BFO_0000051op some obo:TXPO_0000542c
obo:BFO_0000051op some obo:TXPO_0000467c
obo:BFO_0000051op some obo:TXPO_0000566c
obo:BFO_0000051op some obo:TXPO_0000605c
obo:BFO_0000051op some obo:TXPO_0000543c
obo:BFO_0000051op some obo:TXPO_0000546c
obo:BFO_0000051op some obo:TXPO_0000455c

necrosis (course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000678
Description

under construction
Super-classes obo:TXPO_0000323c
Restrictions obo:BFO_0000051op some obo:TXPO_0000030c
obo:BFO_0000051op some obo:TXPO_0000346c
obo:BFO_0000051op some obo:TXPO_0000355c
obo:BFO_0000051op some obo:TXPO_0002381c
obo:BFO_0000051op some obo:TXPO_0002129c
obo:BFO_0000051op some obo:TXPO_0002409c
obo:BFO_0000051op some obo:TXPO_0003344c
obo:BFO_0000051op some obo:TXPO_0000582c
obo:BFO_0000051op some obo:TXPO_0002389c
obo:TXPO_0000004op some obo:TXPO_0002387c
obo:BFO_0000051op some obo:TXPO_0002099c
obo:BFO_0000051op some obo:TXPO_0000541c
obo:BFO_0000051op some obo:TXPO_0000773c
obo:BFO_0000051op some obo:TXPO_0002390c
obo:BFO_0000051op some obo:TXPO_0000527c
obo:BFO_0000051op some obo:TXPO_0002387c
obo:BFO_0000051op some obo:TXPO_0001449c
obo:BFO_0000051op some obo:TXPO_0000486c
obo:BFO_0000051op some obo:TXPO_0002142c
obo:BFO_0000051op some obo:TXPO_0000226c

toxicological imbalance VH< (excess biodefense function)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000679
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL50005C17c)
obo:BFO_0000051op some obo:TXPO_0001735c

toxicological imbalance Mc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000680
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001746c and ub744bL50062C17c and obo:TXPO_0001736c and ub744bL50040C17c)
obo:BFO_0000051op some (obo:TXPO_0001746c and ub744bL50062C17c and obo:TXPO_0001736c and ub744bL50040C17c)

scarringc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000681
Super-classes obo:TXPO_0000219c
Restrictions obo:TXPO_0000531op some obo:PATO_0001850c
Sub-classes obo:TXPO_0003782c

maintaining balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000682
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0003545c
obo:TXPO_0001156c
obo:TXPO_0001434c
obo:TXPO_0000684c
obo:GO_0042592c

maintaining stress response balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000684
Super-classes obo:TXPO_0000682c
Sub-classes obo:TXPO_0000685c

maintaining endoplasmic reticulum stress response balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000685
Super-classes obo:TXPO_0000684c
Sub-classes obo:TXPO_0000686c

maintaining endoplasmic reticulum stress response balance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000686
Super-classes obo:TXPO_0000685c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

increasing demand for response to ER stress (moderate)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000687
Super-classes obo:TXPO_0000362c

increasing demand for response to ER stress (mild)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000688
Super-classes obo:TXPO_0000362c

increasing demand for response to ER stress [ER stress (mild) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000689
Super-classes obo:TXPO_0000734c

increasing the demand for response to ER stress [ER stress] [ER stress (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000690
Super-classes obo:TXPO_0000734c

hypoxia [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000691
Super-classes obo:TXPO_0001717c
obo:MP_0005039c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

lysosomal proliferation in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000692
Super-classes obo:TXPO_0003303c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
obo:RO_0002234op some (obo:GO_0005764c and ub744bL50178C17c)

glycolipid biosynthetic process [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000693
Super-classes obo:TXPO_0001717c
obo:GO_0009247c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

lysosomal cholesterol storage [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000694
Super-classes obo:TXPO_0001716c
obo:TXPO_0001537c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0004158c
obo:TXPO_0003824c

ER stress response gene expression via PERK [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000695
Super-classes obo:TXPO_0001717c
obo:TXPO_0001626c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

changing activity of eIF2a by PERK [PERK - eIF2A pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000696
Super-classes obo:TXPO_0001861c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002755c
obo:TXPO_0000012op some obo:TXPO_0000549c
Sub-classes obo:TXPO_0002378c

eIFF2a phophorylation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000697
Super-classes obo:TXPO_0001899c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000707c
obo:TXPO_0000069op some obo:TXPO_0000416c

gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000698
Description

ATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.
Super-classes obo:TXPO_0003736c
obo:TXPO_0002433c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001907c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002964c
obo:TXPO_0002968c
obo:TXPO_0003056c
obo:TXPO_0003036c
obo:TXPO_0002722c
obo:TXPO_0002562c
obo:TXPO_0002967c
obo:TXPO_0002966c

changing speedc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000699
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000711c

Phosphorylation of eIF2-alpha by PERK [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000700
Description

The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1.
Super-classes obo:TXPO_0000549c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0000829c
obo:TXPO_0001868op some obo:TXPO_0000878c
obo:RO_0002233op some obo:TXPO_0001275c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0003000c
obo:TXPO_0002508c
obo:TXPO_0002507c
obo:TXPO_0002510c
obo:TXPO_0002509c

PERK-eIF2a signaling (integrated pathway)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000701
Super-classes obo:TXPO_0000067c
Restrictions obo:BFO_0000051op some obo:TXPO_0002755c
obo:BFO_0000051op some obo:TXPO_0000696c
obo:BFO_0000051op some obo:TXPO_0001837c
obo:TXPO_0002524op some obo:TXPO_0002754c
obo:BFO_0000051op some obo:TXPO_0000062c
obo:TXPO_0002524op some obo:TXPO_0000285c
Sub-classes obo:TXPO_0002986c
obo:TXPO_0002513c
obo:TXPO_0002797c
obo:TXPO_0002157c
obo:TXPO_0002794c

PLA2G1B(canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000702
Super-classes obo:TXPO_0003555c
obo:TXPO_0003213c
Restrictions obo:TXPO_0002260op some obo:IMR_0000283c
obo:RO_0000087op some obo:TXPO_0003671c

Expression of CHOP (DDIT3, GADD153)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000703
Super-classes obo:GO_0010467c

expression of CCL2c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000704
Description

The CCL2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Super-classes obo:TXPO_0002266c
Sub-classes obo:TXPO_0000709c

IGFBP1 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000705
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_1000208c and ub744bL50371C17c)
Sub-classes obo:TXPO_0000708c

ATF4 gene expression by eIF2ac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000706
Description

Phosphorylation of eIF2-alpha causes increased translation of ATF4 mRNA. In mouse the mRNA of ATF4 contains 2 upstream ORFs (uORFs) (Vattem and Wek 2004). The second uORF overlaps the ORF encoding ATF4 and thus prevents translation of ATF4. When eIF2-alpha is phosphorylated, translation of the uORFs is suppressed and translation of the ORF encoding ATF4 is increased.
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0000707c

ATF4 gene expression by eIF2a [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000707
Super-classes obo:TXPO_0000706c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0001907c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000698c
obo:TXPO_0001868op some obo:TXPO_0000829c
Sub-classes obo:TXPO_0003035c
obo:TXPO_0002721c
obo:TXPO_0003054c

IGFBP1 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000708
Super-classes obo:TXPO_0000705c
obo:TXPO_0003736c
Restrictions obo:RO_0000057op some obo:TXPO_0000776c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0001907c

expression of CCL2 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000709
Super-classes obo:TXPO_0003736c
obo:TXPO_0000704c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002766c
obo:TXPO_0000774op only obo:TXPO_0002528c

ATF6 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000710
Super-classes obo:TXPO_0003736c
obo:TXPO_0001904c
Restrictions obo:BFO_0000051op some obo:TXPO_0002466c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002467c
obo:RO_0002234op some obo:TXPO_0002901c
Sub-classes obo:TXPO_0002918c
obo:TXPO_0001905c
obo:TXPO_0002911c
obo:TXPO_0002924c

Deacreasing velocityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000711
Super-classes obo:TXPO_0000699c
Sub-classes obo:TXPO_0001581c
obo:TXPO_0000896c

PERK dimerizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000712
Super-classes obo:TXPO_0003641c
Sub-classes obo:TXPO_0000713c

PERK dimerization [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000713
Super-classes obo:TXPO_0003736c
obo:TXPO_0000712c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000674c
obo:RO_0000057op some obo:TXPO_0002880c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0003004c
obo:TXPO_0002866c
obo:TXPO_0002855c
obo:TXPO_0000063c
obo:TXPO_0002867c

hypofunction of cholesterol transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000714
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:GO_0030301c
Sub-classes obo:TXPO_0000731c

CYP7A1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000715
Description

RXR heterodimers regulates absorption and ABC1-mediated efflux of cholesterol. Oxysterol receptors (LXRs) and the bile acid receptor (FXR) are the RXR heterodimer by regulating expression of the reverse cholesterol transporter, ABC1, and the enzyme of bile acid synthesis, CYP7A1, respectively.
Super-classes obo:TXPO_0000404c
obo:TXPO_0000276c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001581c

hypofunction of cholesterol transport from lysosome [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000717
Super-classes obo:TXPO_0000731c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003824c
obo:TXPO_0000774op only obo:TXPO_0003452c

ATF6 signaling (primitive) [ATF6 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000718
Super-classes obo:TXPO_0000335c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000879c
Sub-classes obo:TXPO_0000719c
obo:TXPO_0004432c

ATF6 signaling (primitive) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000719
Super-classes obo:TXPO_0000718c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0000710c
obo:TXPO_0001868op some obo:TXPO_0000879c
Sub-classes obo:TXPO_0002691c
obo:TXPO_0002838c
obo:TXPO_0002909c
obo:TXPO_0002550c

IRE1 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000720
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002601c
obo:TXPO_0002524op some obo:TXPO_0002155c
Sub-classes obo:TXPO_0002571c
obo:TXPO_0002593c

IRE1 signaling (primitive) [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000721
Super-classes obo:TXPO_0003736c
obo:TXPO_0002571c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:BFO_0000051op some obo:TXPO_0000721c

attenuation of translation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000722
Super-classes obo:GO_0009386c
obo:TXPO_0001717c
Restrictions obo:BFO_0000051op some obo:TXPO_0000123c
obo:TXPO_0002524op some obo:TXPO_0002157c
obo:BFO_0000051op some obo:TXPO_0000061c
obo:BFO_0000051op some obo:TXPO_0002762c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002853c
obo:TXPO_0002989c

XBP1 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000723
Super-classes obo:TXPO_0000124c
Restrictions obo:RO_0000057op some obo:TXPO_0001968c
obo:RO_0002234op some (obo:TXPO_1000405c and ub744bL50651C17c)
Sub-classes obo:TXPO_0002592c

SLCO1B1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000724
Description

The sodium-independent portion of bile salt uptake is mediated by OATPs (organic anion transporting polypeptides). OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3), and OATP2B1 (SLCO2B1) are expressed at the basolateral plasma membrane of hepatocytes, although OATP2B1 appears not to be a bile Salt transporter.
Super-classes obo:TXPO_0000272c
Restrictions obo:TXPO_0002260op some ncicp:C107150c

XBP1 splicingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000725
Super-classes obo:GO_0008380c
Sub-classes obo:TXPO_0000726c

XBP1 splicing [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000726
Super-classes obo:TXPO_0000725c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002773c
obo:TXPO_0002851c
obo:TXPO_0002871c

ERAD related gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000727
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0002696c
obo:TXPO_0000728c

ERAD related gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000728
Super-classes obo:TXPO_0001717c
obo:TXPO_0000727c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002610c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002709c
obo:BFO_0000051op some obo:TXPO_0002710c
obo:BFO_0000051op some obo:TXPO_0002696c

IRE1 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000729
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_0001528c and ub744bL50732C17c)
Sub-classes obo:TXPO_0002591c

IRE1 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000730
Super-classes obo:TXPO_0003736c
obo:TXPO_0002591c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002596c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002598c
Sub-classes obo:TXPO_0002687c
obo:TXPO_0002686c
obo:TXPO_0002688c
obo:TXPO_0002685c

hypofunction of endosome to lysosome transport of low-density lipoprotein particlec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000731
Super-classes obo:TXPO_0000714c
Restrictions obo:TXPO_0000716op some obo:GO_0090117c
Sub-classes obo:TXPO_0000717c
obo:TXPO_0001556c

ischemia [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000732
Super-classes obo:TXPO_0001717c
obo:TXPO_0000580c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

starvation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000733
Super-classes obo:TXPO_0001717c
obo:TXPO_0000673c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

increasing demand for response to ER stress [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000734
Super-classes obo:TXPO_0001717c
obo:TXPO_0000362c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0000689c
obo:TXPO_0000690c
obo:TXPO_0000363c

response to endoplasmic reticulum stress [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000735
Super-classes obo:GO_0034976c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

PLA2G2E (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000736
Super-classes obo:IMR_0001035c
Sub-classes obo:TXPO_0000924c

Hykk (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000737
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000123688c
obo:RO_0000087op some obo:TXPO_0001548c

Lgpat2c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000738
Super-classes obo:TXPO_0000740c

hepatocyte cell division [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000739
Super-classes obo:TXPO_0003279c
obo:TXPO_0001570c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c
obo:TXPO_0000069op some obo:TXPO_0001422c

Lgpatc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000740
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0002306c
Sub-classes obo:TXPO_0001308c
obo:TXPO_0000738c

supplying (from stored substance(s))c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000741
Description

A process of supplying the operand from the stored substances
Super-classes obo:TXPO_0000380c
Sub-classes obo:TXPO_0004077c

PERK autophosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000742
Super-classes obo:GO_0046777c
Sub-classes obo:TXPO_0000674c

SLCO1B3 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000743
Description

The sodium-independent portion of bile salt uptake is mediated by OATPs (organic anion transporting polypeptides). OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3), and OATP2B1 (SLCO2B1) are expressed at the basolateral plasma membrane of hepatocytes, although OATP2B1 appears not to be a bile Salt transporter.
Super-classes obo:TXPO_0000272c
Restrictions obo:TXPO_0002260op some ncicp:C107150c

Removing dead cell by Kupffer cell or macrophagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000744
Super-classes obo:TXPO_0000458c

increasing number of stress responses [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000745
Super-classes obo:TXPO_0001717c
obo:TXPO_0000216c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000752c
obo:TXPO_0000774op only obo:TXPO_0002528c

moving drug to hepatocyte [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000746
Super-classes obo:TXPO_0001729c
obo:TXPO_0001684c
Restrictions obo:RO_0000057op some obo:TXPO_0000122c
obo:RO_0000057op some obo:TXPO_0000121c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0001005c

increasing demand for protein quality controlc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000747
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0000748c

increasing demand for protein quality control [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000748
Super-classes obo:TXPO_0001717c
obo:TXPO_0000747c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

cholestasis dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000749
Description

under construction
Super-classes obo:TXPO_0000273c
Sub-classes obo:TXPO_0002720c
obo:TXPO_0003118c
obo:TXPO_0002707c
obo:TXPO_0002697c
obo:TXPO_0000032c
obo:TXPO_0000931c
obo:TXPO_0001885c
obo:TXPO_0003115c
obo:TXPO_0002702c
obo:TXPO_0003131c
obo:TXPO_0003132c

endoplasmic reticulum dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000751
Super-classes obo:TXPO_0000438c
Restrictions obo:BFO_0000066op only obo:GO_0005783c
obo:RO_0000057op some obo:GO_0005783c
Sub-classes obo:TXPO_0000752c

endoplasmic reticulum dysfunction [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000752
Super-classes obo:TXPO_0001717c
obo:TXPO_0000751c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002188c
obo:TXPO_0000069op some obo:TXPO_0002197c
obo:TXPO_0000069op some obo:TXPO_0002194c
obo:TXPO_0000069op some obo:TXPO_0002199c
obo:TXPO_0000069op some obo:TXPO_0002191c
obo:TXPO_0000069op some obo:TXPO_0003276c
obo:BFO_0000066op some obo:GO_0005783c

ER stress dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000753
Super-classes obo:TXPO_0000794c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0000087c
obo:TXPO_0002164c
obo:TXPO_0000779c
obo:TXPO_0000783c
obo:TXPO_0000768c
obo:TXPO_0000771c

cxcl10 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000754
Super-classes obo:TXPO_0003281c
Restrictions obo:RO_0000056op some obo:TXPO_0000192c
obo:TXPO_0000756op some ncicp:C15958c

regulation of lysophagyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000755
Super-classes obo:GO_0010506c
Restrictions obo:RO_0002211op some obo:GO_0062093c
Sub-classes obo:TXPO_0001258c
obo:TXPO_0000757c

positive regulation of lysophagyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000757
Super-classes obo:GO_0010508c
obo:TXPO_0000755c
Restrictions obo:RO_0002213op some obo:GO_0062093c
Sub-classes obo:TXPO_0000797c

tumorigenesis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000758
Super-classes obo:TXPO_0001717c
obo:NCIT_C18121c
Restrictions obo:BFO_0000051op some obo:TXPO_0002534c
obo:BFO_0000051op some obo:TXPO_0000767c
obo:RO_0000057op some obo:TXPO_0001968c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0000754c
obo:TXPO_0000069op some obo:TXPO_0000764c
obo:BFO_0000051op some obo:TXPO_0002535c
obo:BFO_0000066op some obo:UBERON_0002107c

activator of tumor cell activity rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000759
Super-classes obo:TXPO_0003725c

inflammatory response [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000760
Super-classes obo:TXPO_0000192c
obo:TXPO_0001717c
Restrictions obo:RO_0000057op some obo:TXPO_0002768c
obo:TXPO_0000069op some obo:TXPO_0000758c
obo:TXPO_0000069op some obo:TXPO_0000817c
obo:BFO_0000051op some obo:TXPO_0002766c
obo:RO_0000057op some obo:TXPO_0000754c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:UBERON_0002107c

NfkB signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000761
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0000069op some obo:GO_0043066c
obo:TXPO_0000069op some obo:GO_0008283c
obo:TXPO_0000069op some obo:TXPO_0000192c
obo:TXPO_0000069op some obo:NCIT_C16407c
obo:TXPO_0002524op some obo:TXPO_0002774c
Sub-classes obo:TXPO_0000762c
obo:TXPO_0004298c
obo:TXPO_0004251c

NfkB signaling (primitive) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000762
Super-classes obo:TXPO_0000761c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

bone-marrow-derived inhibitory cell migrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000763
Super-classes obo:GO_0016477c

macrophage migration [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000764
Super-classes obo:GO_1905517c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

generating motionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000765
Super-classes obo:TXPO_0000381c
Sub-classes obo:TXPO_0003129c
obo:GO_0040011c
obo:TXPO_0000007c

tumor growthc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000766
Super-classes obo:GO_0016049c
Sub-classes obo:TXPO_0002245c
obo:TXPO_0000767c
obo:TXPO_0001028c

tumor growth [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000767
Super-classes obo:TXPO_0000766c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

Hmox1 (rat)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000768
Super-classes obo:TXPO_0000753c
obo:TXPO_1000196c
Restrictions obo:RO_0000056op some obo:TXPO_0000770c
obo:RO_0000056op some obo:TXPO_0000204c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000056op some obo:TXPO_0000376c
obo:RO_0000087op some obo:CHEBI_22586c

JNK signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000769
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0031098c
Sub-classes obo:TXPO_0004489c
obo:TXPO_0004249c
obo:TXPO_0002375c
obo:TXPO_0000770c
obo:TXPO_0000536c

JNK signaling (primitive) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000770
Super-classes obo:TXPO_0000769c
obo:TXPO_0001717c
Restrictions obo:RO_0000057op some obo:TXPO_0000768c
obo:TXPO_0000069op some obo:TXPO_0000204c
obo:TXPO_0000774op only obo:TXPO_0002528c

Cebpd (rat)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000771
Super-classes obo:TXPO_1000415c
obo:TXPO_0000753c
Restrictions obo:RO_0000056op some obo:TXPO_0000760c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0003645c

group XV phospholipaseA2c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000772
Super-classes obo:IMR_0000283c
Sub-classes obo:TXPO_1000281c

DNA damage (severe) [necrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000773
Super-classes obo:TXPO_0001727c
obo:NCIT_C16507c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002387c
obo:TXPO_0000774op only obo:TXPO_0000678c

PLA2G15 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000775
Super-classes obo:TXPO_0003213c
obo:TXPO_1000281c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:TXPO_0004072c

IGFBP1 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000776
Super-classes obo:TXPO_1000208c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

Arrb2 (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000777
Super-classes obo:TXPO_0000780c
obo:TXPO_0001071c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0000756op some obo:TXPO_0000489c
Sub-classes obo:TXPO_0000784c

CCL2 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000778
Description

PERK->ATF4->CCl2 reactome
Super-classes obo:TXPO_1000086c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

Trib3 (rat)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000779
Super-classes obo:TXPO_0000753c
obo:TXPO_1000378c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

ARRB2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000780
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000777c

negative regulation of AKT signaling [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000781
Super-classes obo:TXPO_0001728c
obo:GO_0051898c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0000777c
obo:TXPO_0000069op some obo:TXPO_0001026c

malfunction of mitochondrial functionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000782
Super-classes obo:TXPO_0000434c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0001810c

Dnajb9 (rat)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000783
Super-classes obo:TXPO_1000114c
obo:TXPO_0000753c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
obo:TXPO_0000756op some obo:TXPO_0000489c

Arrb2 -inactivation (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000784
Description

ARRB2, GSK3beta->CAR, Cyp2B6?
Super-classes obo:TXPO_0000777c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0001733op some obo:PATO_0002355c

GPRC5B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000785
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000786c

GPRC5B (human)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000786
Super-classes obo:TXPO_0001009c
obo:TXPO_0000785c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c

tamoxifen [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000787
Super-classes obo:TXPO_0003508c
obo:CHEBI_41774c
Sub-classes obo:TXPO_0001975c
obo:TXPO_0002019c

valproic acid [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000788
Super-classes obo:CHEBI_39867c
Sub-classes obo:TXPO_0001976c

increasing demand for drug metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000789
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0000803c
obo:TXPO_0002326c

Creld2 (mouse)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000790
Super-classes obo:TXPO_0000812c
obo:TXPO_1000075c
Restrictions obo:RO_0000056op some obo:TXPO_0000719c

Ddit3 (mouse)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000791
Super-classes obo:TXPO_0000812c
obo:TXPO_1000067c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c

Bhlha15 (mouse)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000792
Super-classes obo:TXPO_0000812c
obo:TXPO_1000045c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

ER stress dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000793
Super-classes obo:TXPO_0000794c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
obo:TXPO_0000756op some obo:TXPO_0000795c
Sub-classes obo:TXPO_0000796c
obo:TXPO_0000806c
obo:TXPO_0000800c
obo:TXPO_0002169c
obo:TXPO_0002167c
obo:TXPO_0000810c
obo:TXPO_0002165c
obo:TXPO_0003341c
obo:TXPO_0000811c
obo:TXPO_0002168c
obo:TXPO_0000778c
obo:TXPO_0000807c
obo:TXPO_0000798c
obo:TXPO_0000805c
obo:TXPO_0002166c
obo:TXPO_0000802c
obo:TXPO_0000776c

ER stress dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000794
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0000812c
obo:TXPO_0003012c
obo:TXPO_0000753c
obo:TXPO_0000793c
obo:TXPO_0000871c

in vitro assay (human)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000795
Super-classes ncicp:C15958c
Sub-classes obo:TXPO_0001442c
obo:TXPO_0003631c
obo:TXPO_0003437c

FGF21 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000796
Super-classes obo:TXPO_1000145c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026291c
obo:TXPO_0000756op some obo:TXPO_0000795c
obo:TXPO_0002260op some obo:IMR_0100571c

positive regulation of lysophagy [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000797
Super-classes obo:TXPO_0001716c
obo:TXPO_0000757c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
obo:TXPO_0000069op some obo:TXPO_0002245c

MANF (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000798
Super-classes obo:TXPO_1000233c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007873c
obo:RO_0000056op some obo:TXPO_0000376c
obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000056op some obo:TXPO_0000831c
obo:RO_0000087op some obo:TXPO_0000832c

permeating mitochondrial membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000799
Super-classes obo:TXPO_0000429c

HYOU1 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000800
Super-classes obo:TXPO_0000793c
obo:TXPO_1000191c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000010525c
Sub-classes obo:TXPO_0000561c

DNAJB9 - chaperone -vitro (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000801
Super-classes obo:TXPO_0002165c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c
obo:RO_0000087op only obo:TXPO_0003997c

HSP90B1 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000802
Super-classes obo:TXPO_1000171c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007184c
obo:RO_0000087op some obo:TXPO_0003997c
Sub-classes obo:TXPO_0003735c
obo:TXPO_0000828c
obo:TXPO_0003485c

increasing demand for drug metabolism [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000803
Super-classes obo:TXPO_0000789c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

aldehyde-lyasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000804
Super-classes obo:TXPO_0000308c
Sub-classes obo:TXPO_0000676c

ERO1LB (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000805
Super-classes obo:TXPO_1000126c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c

GFPT1 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000806
Description

IRE1->Xbp1->GFPT1 reactome
Super-classes obo:TXPO_0000793c
obo:TXPO_1000166c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c
obo:TXPO_0000819op some obo:OGG_3000002673c

CHAC1 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000807
Super-classes obo:TXPO_1000066c
obo:TXPO_0000793c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000079094c

disease course dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000808
Super-classes obo:TXPO_0000271c
Sub-classes obo:TXPO_0003342c
obo:TXPO_0003642c

insulin resistance [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000809
Super-classes obo:TXPO_0003496c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001095c
obo:TXPO_0000774op only obo:TXPO_0000888c

HERPUD1 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000810
Super-classes obo:TXPO_1000184c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009709c

SEC61B (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000811
Super-classes obo:TXPO_1000335c
obo:TXPO_0000793c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c
obo:TXPO_0000819op some obo:OGG_3000010952c

ER stress dependent moleule (mouse)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000812
Super-classes obo:TXPO_0000794c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10090c
Sub-classes obo:TXPO_0003277c
obo:TXPO_0000792c
obo:TXPO_0000791c
obo:TXPO_0000790c
obo:TXPO_0003274c

tumor cell survial [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000813
Super-classes obo:TXPO_0000889c
obo:NCIT_C16407c
Restrictions obo:RO_0000057op some obo:TXPO_0000663c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0000079c

cell death [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000814
Super-classes obo:GO_0008219c
obo:TXPO_0001730c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000815c
obo:TXPO_0000774op only obo:TXPO_0000677c
obo:TXPO_0000069op some obo:TXPO_0002333c

Inflammatory response [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000815
Super-classes obo:TXPO_0001730c
obo:TXPO_0000192c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:BFO_0000051op some obo:TXPO_0000842c

hepatic fibrosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000816
Super-classes obo:TXPO_0000219c
Restrictions obo:BFO_0000066op only obo:UBERON_0002107c
Sub-classes obo:TXPO_0004279c
obo:TXPO_0001850c
obo:TXPO_0003621c
obo:TXPO_0004818c
obo:TXPO_0003802c
obo:TXPO_0003169c
obo:TXPO_0003211c
obo:TXPO_0004141c
obo:TXPO_0000817c

hepatic fibrosis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000817
Super-classes obo:TXPO_0001717c
obo:TXPO_0000816c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000206c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0002528c

protein production [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000818
Super-classes obo:TXPO_0000382c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

membrane protein productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000820
Super-classes obo:TXPO_0000382c

lysosome homeostasis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000821
Super-classes obo:TXPO_0000470c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

decreasing amount of xenobioticsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000822
Super-classes obo:TXPO_0000396c
Restrictions obo:BFO_0000051op some obo:GO_0006805c
Sub-classes obo:TXPO_0001639c

transmembrane receptor protein tyrosine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000823
Description

related molecular function GO:0004714
Super-classes obo:TXPO_0002292c

IRE - stress sensor (canonical)[ER stress -Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000824
Super-classes obo:TXPO_0002602c
Restrictions obo:RO_0000056op some obo:TXPO_0002957c
obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000087op some obo:TXPO_0000881c

functional attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000825
Super-classes obo:TXPO_0000305c

negative regulation of phospholipase A2 mediated phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000827
Super-classes obo:TXPO_0001256c

HSP90B1 - chaperone -vitro (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000828
Super-classes obo:TXPO_0000802c
Restrictions obo:RO_0000087op only obo:TXPO_0003997c
obo:TXPO_0000756op some obo:TXPO_0000795c

P-EIF2A (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000829
Super-classes obo:TXPO_0001275c
Restrictions obo:RO_0000087op some obo:TXPO_0001909c
Sub-classes obo:TXPO_0002556c
obo:TXPO_0002931c
obo:TXPO_0002555c
obo:TXPO_0002896c

IL-2 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000830
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0038110c
Sub-classes obo:TXPO_0000833c

cell proliferation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000831
Super-classes obo:GO_0008283c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:UBERON_0002107c

cell death inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000832
Super-classes obo:TXPO_0002406c
Restrictions obo:RO_0002599op some obo:GO_0008219c

IL-2 signaling (primitive) [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000833
Super-classes obo:TXPO_0001716c
obo:TXPO_0000830c
Restrictions obo:RO_0000057op some obo:TXPO_0002288c
obo:RO_0000057op some obo:TXPO_0001143c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001495c
Sub-classes obo:TXPO_0003405c
obo:TXPO_0003406c
obo:TXPO_0003407c

fatty acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000834
Super-classes obo:CHEBI_18059c
obo:TXPO_0001144c
Sub-classes obo:TXPO_0001152c

eosinogranular degeneration dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000835
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
Sub-classes obo:TXPO_0000648c
obo:TXPO_0002383c
obo:TXPO_0001280c
obo:TXPO_0001077c
obo:TXPO_0001034c

tumor cell survial [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000836
Super-classes obo:TXPO_0000280c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0003582c
obo:RO_0000057op some obo:TXPO_0002553c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001140c

liver cancer dependent moleculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000837
Description

under construction
Super-classes obo:TXPO_0000199c
Sub-classes obo:TXPO_0004080c
obo:TXPO_0005072c
obo:TXPO_0004042c
obo:TXPO_0004024c
obo:TXPO_0004064c
obo:TXPO_0004057c
obo:TXPO_0004054c
obo:TXPO_0004068c
obo:TXPO_0004031c
obo:TXPO_0004036c
obo:TXPO_0004039c
obo:TXPO_0004063c
obo:TXPO_0004078c
obo:TXPO_0004059c
obo:TXPO_0004025c
obo:TXPO_0004849c
obo:TXPO_0004027c
obo:TXPO_0004076c
obo:TXPO_0004089c
obo:TXPO_0005070c
obo:TXPO_0004041c
obo:TXPO_0004094c
obo:TXPO_0004017c
obo:TXPO_0004005c
obo:TXPO_0004067c
obo:TXPO_0004055c
obo:TXPO_0004060c
obo:TXPO_0005063c
obo:TXPO_0004051c
obo:TXPO_0004073c
obo:TXPO_0003994c
obo:TXPO_0004185c
obo:TXPO_0004038c
obo:TXPO_0004013c
obo:TXPO_0004037c
obo:TXPO_0004091c
obo:TXPO_0004021c
obo:TXPO_0004071c
obo:TXPO_0004022c
obo:TXPO_0004093c
obo:TXPO_0004030c
obo:TXPO_0004029c
obo:TXPO_0004058c
obo:TXPO_0004056c
obo:TXPO_0004033c
obo:TXPO_0004083c
obo:TXPO_0004062c
obo:TXPO_0004074c
obo:TXPO_0004075c

cell death dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000838
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
Sub-classes obo:TXPO_0000839c
obo:TXPO_0003195c
obo:TXPO_0000840c

cell death dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000839
Super-classes obo:TXPO_0000838c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0000853c
obo:TXPO_0000650c
obo:TXPO_0000642c
obo:TXPO_0004044c
obo:TXPO_0000641c
obo:TXPO_0000645c
obo:TXPO_0000640c

cell death dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000840
Super-classes obo:TXPO_0000838c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
Sub-classes obo:TXPO_0000863c
obo:TXPO_0000864c
obo:TXPO_0000866c
obo:TXPO_0000518c
obo:TXPO_0000867c
obo:TXPO_0000581c

increasing liver weight [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000841
Super-classes obo:TXPO_0000054c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001140c

inflammatory cytokine gene expression [Oxidative stress].c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000842
Super-classes obo:TXPO_0002266c
obo:TXPO_0001730c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c

TP53 (canonical)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000843
Super-classes obo:TXPO_0003195c
obo:IMR_0100659c
Sub-classes obo:TXPO_0003217c
obo:TXPO_0002382c

inflammasome activation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000844
Super-classes obo:TXPO_0000889c
obo:TXPO_0001107c
Restrictions obo:RO_0000057op some obo:TXPO_0000894c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003209c
obo:RO_0000057op some obo:TXPO_0000850c

MDM2 (canonical)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000845
Super-classes obo:IMR_0100660c
obo:TXPO_0003195c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c

Acot5 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000846
Super-classes obo:TXPO_0000648c
obo:TXPO_0000868c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Hmgb1 (mouse)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000847
Super-classes obo:TXPO_0000849c
obo:TXPO_0002285c

increasing demand for glutathione conjugationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000848
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0001185c

HMGB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000849
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000847c
obo:TXPO_0004619c

NRF2 -inflammasone activator (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000850
Super-classes obo:TXPO_0002045c
obo:TXPO_0002392c
Restrictions obo:RO_0000087op some obo:TXPO_0000851c

inflammasome activatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000851
Super-classes obo:TXPO_0003714c

increasing blood ALT concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000852
Super-classes obo:TXPO_0000352c
Restrictions obo:RO_0002234op some (obo:TXPO_0001022c and ub744bL52284C17c)
Sub-classes obo:TXPO_0000860c

Jund (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000853
Super-classes obo:IMR_0000819c
obo:TXPO_0000839c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

core process (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000854
Super-classes obo:TXPO_0002178c

NRF2 -antioxidant (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000855
Super-classes obo:TXPO_0002392c
Restrictions obo:RO_0000087op some obo:CHEBI_22586c
obo:RO_0000087op some obo:TXPO_0003645c
obo:TXPO_0001896op some obo:TXPO_0000656c

GGT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000856
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000858c
Sub-classes obo:TXPO_0000857c

GGT1 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000857
Super-classes obo:TXPO_0003516c
obo:TXPO_0000856c
Restrictions obo:RO_0000087op some obo:TXPO_0000858c

gamma-glutamyltransferase.c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000858
Description

The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions
Super-classes obo:TXPO_0001385c

increasing γ-glutamyltransferase concentration in blood [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000859
Super-classes obo:TXPO_0001720c
obo:TXPO_0001347c
Restrictions obo:RO_0002234op some obo:TXPO_0000857c
obo:TXPO_0000774op only obo:TXPO_0001155c

increasing blood ALT concentration [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000860
Super-classes obo:TXPO_0001720c
obo:TXPO_0000852c
Restrictions obo:RO_0002234op some obo:TXPO_0001024c
obo:TXPO_0000774op only obo:TXPO_0001155c

increasing blood AST concentration [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000861
Super-classes obo:TXPO_0001720c
obo:TXPO_0000643c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0002234op some obo:TXPO_0001017c

leaking content from cell [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000862
Super-classes obo:TXPO_0001720c
obo:TXPO_0000526c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000861c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0003622c
obo:TXPO_0000069op some obo:TXPO_0000860c
obo:TXPO_0000069op some obo:TXPO_0000859c

TNF (human)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000863
Super-classes obo:TXPO_0000840c
obo:TXPO_1000374c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000007124c

BCL2 (human)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000864
Super-classes obo:TXPO_1000041c
obo:TXPO_0000840c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000000596c

concentration (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000865
Super-classes obo:TXPO_0000305c

BAD (human)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000866
Super-classes obo:TXPO_0000840c
obo:IMR_0100288c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000572c
obo:TXPO_0000756op some ncicp:C15958c

FASLG (human)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000867
Super-classes obo:TXPO_0000840c
obo:TXPO_1000140c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000000356c

Acot5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000868
Super-classes obo:TXPO_0001146c
Sub-classes obo:TXPO_0000846c

mitochondrial respiratory chain abnormality [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000869
Super-classes obo:TXPO_0001987c
obo:TXPO_0001846c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004264c
obo:RO_0000057op some obo:TXPO_0004333c
obo:RO_0000057op some obo:TXPO_0004339c
obo:RO_0000057op some obo:TXPO_0004338c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0000057op some obo:TXPO_0004331c
obo:RO_0000057op some obo:TXPO_0004337c
obo:RO_0000057op some obo:TXPO_0004334c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:RO_0000057op some obo:TXPO_0004335c
obo:RO_0000057op some obo:TXPO_0004336c
obo:RO_0000057op some obo:TXPO_0004330c
obo:RO_0000057op some obo:TXPO_0004332c
obo:BFO_0000051op some obo:TXPO_0004225c

Acot8 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000870
Super-classes obo:TXPO_1000026c
obo:TXPO_0000648c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

ER stress dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000871
Super-classes obo:TXPO_0000794c
Sub-classes obo:TXPO_0002771c
obo:TXPO_0003069c
obo:TXPO_0001813c
obo:TXPO_0000047c
obo:TXPO_0000879c
obo:TXPO_0003086c
obo:TXPO_0002699c
obo:TXPO_0001907c
obo:TXPO_0002385c
obo:TXPO_0003052c
obo:TXPO_0004578c
obo:TXPO_0000873c
obo:TXPO_0003037c
obo:TXPO_0002769c
obo:TXPO_0001968c
obo:TXPO_0003006c
obo:TXPO_0002880c
obo:TXPO_0002108c
obo:TXPO_0000301c
obo:TXPO_0002934c
obo:TXPO_0002105c
obo:TXPO_0003082c
obo:TXPO_0003039c
obo:TXPO_0001960c
obo:TXPO_0002897c
obo:TXPO_0002955c
obo:TXPO_0000878c
obo:TXPO_0002410c
obo:TXPO_0000502c
obo:TXPO_0002818c
obo:TXPO_0002942c
obo:TXPO_0002497c
obo:TXPO_0002972c
obo:TXPO_0001275c
obo:TXPO_0002601c
obo:TXPO_0001877c
obo:TXPO_0002411c
obo:TXPO_0002776c
obo:TXPO_0003048c
obo:TXPO_0002921c
obo:TXPO_0002914c

dissociation of BIP complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000872
Super-classes obo:TXPO_0000462c
Restrictions obo:BFO_0000066op some obo:GO_0005789c
obo:RO_0002234op some obo:TXPO_0001002c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002106c
Sub-classes obo:TXPO_0000505c

AMPK (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000873
Super-classes obo:TXPO_0000871c
obo:TXPO_0003221c
Restrictions obo:TXPO_0002260op some obo:TXPO_0003221c

negative regulation of endoplasmic reticulum-associated degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000874
Super-classes obo:GO_0042177c
Restrictions obo:RO_0002212op some obo:GO_0071712c
Sub-classes obo:TXPO_0003016c

IRE - stress sensor (canonical)[ER stress -ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000875
Super-classes obo:TXPO_0002602c
Restrictions obo:RO_0000087op some obo:TXPO_0000881c
obo:TXPO_0000774op only obo:TXPO_0000386c
obo:RO_0000056op some obo:TXPO_0002710c

PERK inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000876
Super-classes obo:TXPO_0003711c

KEAP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000877
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001172c

PERK (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000878
Super-classes obo:TXPO_0001792c
obo:TXPO_0000871c
Restrictions obo:RO_0000056op some obo:TXPO_0002741c
obo:TXPO_0000819op some obo:OGG_3000009451c
Sub-classes obo:TXPO_0002846c
obo:TXPO_0002839c
obo:TXPO_0002859c
obo:TXPO_0001852c
obo:TXPO_0002862c
obo:TXPO_0002860c
obo:TXPO_0002863c
obo:TXPO_0002856c
obo:TXPO_0002861c
obo:TXPO_0002845c
obo:TXPO_0002864c
obo:TXPO_0002999c
obo:TXPO_0001841c
obo:TXPO_0002996c
obo:TXPO_0002857c
obo:TXPO_0002998c
obo:TXPO_0002858c

ATF6 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000879
Super-classes obo:TXPO_0000871c
obo:TXPO_1000013c
Restrictions obo:TXPO_0002260op some obo:IMR_0000825c
Sub-classes obo:TXPO_0000044c
obo:TXPO_0003032c
obo:TXPO_0002900c
obo:TXPO_0002468c

amiodarone [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000880
Super-classes obo:CHEBI_2663c
obo:TXPO_0003508c
Sub-classes obo:TXPO_0001983c
obo:TXPO_0002026c

stress sensorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000881
Super-classes obo:TXPO_0000882c

sensorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000882
Super-classes obo:TXPO_0003728c
Sub-classes obo:TXPO_0004296c
obo:TXPO_0000881c
obo:TXPO_0003863c
obo:TXPO_0001682c

negative regulation of immune responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000883
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006955c

hyperfunction of dead cell phagocytosis by Kupffer cells (macrophages)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000884
Super-classes obo:TXPO_0002279c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000744c
Sub-classes obo:TXPO_0001257c

nucleocytoplasmic carrierc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000885
Description

relatd molecular function GO:0140142
Super-classes obo:TXPO_0003723c

ER processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000886
Super-classes obo:TXPO_0000538c

gene expression regulation systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000887
Super-classes obo:TXPO_0000603c
Sub-classes obo:TXPO_0001414c
obo:TXPO_0001429c
obo:TXPO_0001436c
obo:TXPO_0001211c
obo:TXPO_0002526c

lipidosis [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000888
Super-classes obo:TXPO_0001155c
Restrictions obo:BFO_0000051op some obo:TXPO_0000890c
obo:BFO_0000051op some obo:TXPO_0000898c
obo:BFO_0000051op some obo:TXPO_0000901c
obo:BFO_0000051op some obo:TXPO_0003494c
obo:TXPO_0000004op some obo:TXPO_0001129c
obo:BFO_0000051op some obo:TXPO_0000899c
obo:BFO_0000051op some obo:TXPO_0000891c
obo:BFO_0000051op some obo:TXPO_0000893c
obo:BFO_0000051op some obo:TXPO_0000892c
obo:BFO_0000051op some obo:TXPO_0003507c
obo:BFO_0000051op some obo:TXPO_0003484c
obo:BFO_0000051op some obo:TXPO_0001129c
obo:BFO_0000051op some obo:TXPO_0003491c
Sub-classes obo:TXPO_0001041c
obo:TXPO_0003498c
obo:TXPO_0001535c

glutathione depletion dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000889
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
Sub-classes obo:TXPO_0001450c
obo:TXPO_0000904c
obo:TXPO_0001182c
obo:TXPO_0001184c
obo:TXPO_0002613c
obo:TXPO_0002379c
obo:TXPO_0002491c
obo:TXPO_0001190c
obo:TXPO_0002367c
obo:TXPO_0001149c
obo:TXPO_0003169c
obo:TXPO_0002434c
obo:TXPO_0001202c
obo:TXPO_0002372c
obo:TXPO_0001200c
obo:TXPO_0000656c
obo:TXPO_0003168c
obo:TXPO_0001955c
obo:TXPO_0003175c
obo:TXPO_0002369c
obo:TXPO_0001181c
obo:TXPO_0003180c
obo:TXPO_0001199c
obo:TXPO_0001179c
obo:TXPO_0002407c
obo:TXPO_0002564c
obo:TXPO_0002216c
obo:TXPO_0002404c
obo:TXPO_0001207c
obo:TXPO_0003177c
obo:TXPO_0002373c
obo:TXPO_0001178c
obo:TXPO_0003173c
obo:TXPO_0002370c
obo:TXPO_0000117c
obo:TXPO_0000813c
obo:TXPO_0002375c
obo:TXPO_0000844c
obo:TXPO_0001197c
obo:TXPO_0001920c
obo:TXPO_0003185c
obo:TXPO_0001196c
obo:TXPO_0002371c
obo:TXPO_0001933c
obo:TXPO_0002734c
obo:TXPO_0001187c
obo:TXPO_0002431c
obo:TXPO_0002363c
obo:TXPO_0002582c
obo:TXPO_0003288c
obo:TXPO_0003186c
obo:TXPO_0002759c
obo:TXPO_0001925c
obo:TXPO_0001192c
obo:TXPO_0002733c
obo:TXPO_0001204c
obo:TXPO_0001944c
obo:TXPO_0002368c
obo:TXPO_0003178c
obo:TXPO_0001193c
obo:TXPO_0001203c
obo:TXPO_0002366c
obo:TXPO_0002430c
obo:TXPO_0001206c
obo:TXPO_0003520c
obo:TXPO_0001205c
obo:TXPO_0000655c
obo:TXPO_0001923c
obo:TXPO_0002376c
obo:TXPO_0003183c
obo:TXPO_0001189c
obo:TXPO_0003208c
obo:TXPO_0001183c
obo:TXPO_0000675c
obo:TXPO_0003189c
obo:TXPO_0001188c
obo:TXPO_0001180c
obo:TXPO_0004098c
obo:TXPO_0001194c
obo:TXPO_0003209c
obo:TXPO_0003181c
obo:TXPO_0002711c
obo:TXPO_0003174c
obo:TXPO_0001191c
obo:TXPO_0001198c
obo:TXPO_0002254c
obo:TXPO_0001185c
obo:TXPO_0001201c

hyperfunction of fatty acid biosynthesis [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000890
Super-classes obo:TXPO_0002335c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000898c
obo:TXPO_0001868op some obo:TXPO_0003812c
obo:TXPO_0000774op only obo:TXPO_0000888c

hypofunction of lipid degradation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000891
Super-classes obo:TXPO_0001720c
obo:TXPO_0002006c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000051op some obo:TXPO_0001036c
obo:TXPO_0000069op some obo:TXPO_0000893c

increaing in fatty acid inflow into hepatocyte [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000892
Super-classes obo:TXPO_0001720c
obo:TXPO_0003492c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003494c
Sub-classes obo:TXPO_0003811c

lipid metabolism imbalance [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000893
Super-classes obo:TXPO_0002336c
obo:TXPO_0001160c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003491c
obo:TXPO_0000774op only obo:TXPO_0000888c
Sub-classes obo:TXPO_0001039c
obo:TXPO_0001044c
obo:TXPO_0001040c

CASP1 (predicted)(human)[Glutathone depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000894
Description

predicted gene by Support Vector Machine (SVM) using human primary hepatocyte
Super-classes obo:TXPO_0001916c
obo:IMR_0100302c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000000834c

biological membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000895
Super-classes obo:GO_0005575c
Sub-classes obo:GO_0005886c
obo:GO_0031090c

Deacreasing flow ratec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000896
Super-classes obo:TXPO_0000711c

lipid storage in liver [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000897
Super-classes obo:TXPO_0001720c
obo:TXPO_0001276c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

hyperfunction of lipid biosynthesis [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000898
Super-classes obo:TXPO_0001720c
obo:TXPO_0002337c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000893c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000051op some obo:TXPO_0000890c

hyperfunction of lipid synthetic gene expression [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000899
Super-classes obo:TXPO_0002338c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000898c
obo:TXPO_0000069op some obo:TXPO_0000890c
obo:RO_0000057op some obo:TXPO_0001301c
obo:RO_0000057op some obo:TXPO_0001401c
obo:TXPO_0001868op some obo:TXPO_0001108c
obo:TXPO_0001868op some obo:TXPO_0003812c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:RO_0000057op some obo:TXPO_0001394c

alcohol metabolic process [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000900
Super-classes obo:TXPO_0001720c
obo:GO_0006066c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0000892c

hypofunction of mitochondrial fatty acid beta-oxidation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000901
Super-classes obo:TXPO_0001720c
obo:TXPO_0002112c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001036c
obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0001739c
obo:TXPO_0001539c

changing abnormal cellular structure [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000902
Super-classes obo:TXPO_0001770c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

increasing phospholipid inflow (severe) [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000903
Super-classes obo:TXPO_0001251c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003435c
obo:TXPO_0000774op only obo:TXPO_0002215c

NRF2 signaling (primitive) [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000904
Super-classes obo:TXPO_0000889c
obo:TXPO_0000449c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002379c
obo:TXPO_0000069op some obo:TXPO_0002367c
obo:RO_0000057op some obo:TXPO_0002392c
obo:TXPO_0000069op some obo:TXPO_0002430c
obo:TXPO_0000069op some obo:TXPO_0000844c
obo:TXPO_0000069op some obo:TXPO_0001149c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001194c
obo:TXPO_0000069op some obo:TXPO_0002368c
obo:TXPO_0000069op some obo:TXPO_0000813c
obo:RO_0000057op some obo:TXPO_0001934c
obo:TXPO_0000069op some obo:TXPO_0002363c

negative regulation of phospholipid degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000905
Super-classes obo:TXPO_0001716c
obo:TXPO_0001256c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000925c
Sub-classes obo:TXPO_0003444c
obo:TXPO_0002217c
obo:TXPO_0002087c
obo:TXPO_0001788c
obo:TXPO_0004933c

IRE - stress sensor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000906
Super-classes obo:TXPO_0002602c
Restrictions obo:RO_0000056op some obo:TXPO_0002710c
obo:RO_0000087op some obo:TXPO_0000881c
obo:TXPO_0000774op only obo:TXPO_0000386c

phospholipid homeostasis imbalance [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000907
Super-classes obo:TXPO_0001243c
obo:TXPO_0000951c
Restrictions obo:BFO_0000051op some obo:TXPO_0002324c
obo:TXPO_0000069op some obo:TXPO_0000910c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0003435c
obo:TXPO_0004155c
obo:TXPO_0003985c
obo:TXPO_0003370c
obo:TXPO_0003984c
obo:TXPO_0004159c

hyperfunction of phospholipid biosynthesis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000908
Super-classes obo:TXPO_0001410c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002324c
obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0001708c
obo:TXPO_0001704c

increasing demand for phospholipid degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000909
Super-classes obo:TXPO_0001248c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000907c

phospholipid accumulation in lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000910
Super-classes obo:TXPO_0001716c
obo:TXPO_0000281c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0002070c
obo:TXPO_0003371c
obo:TXPO_0001824c
obo:TXPO_0000920c
obo:TXPO_0003381c

hypofunction of phospholipase transport to lysosome [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000911
Super-classes obo:TXPO_0001769c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002217c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000716op some obo:TXPO_0003354c

increasing lysosomal pH [Phospholipidosis(severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000912
Super-classes obo:TXPO_0001716c
obo:TXPO_0001247c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003435c
obo:TXPO_0001868op some obo:TXPO_0003345c
obo:TXPO_0000069op some obo:TXPO_0002240c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0001778c

forming a complex of drugs and biological substance [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000913
Super-classes obo:TXPO_0001254c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000069op some obo:TXPO_0002087c
obo:TXPO_0000774op only obo:TXPO_0002215c

hypofunction of phospholipid deradation by phospholipase [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000914
Super-classes obo:TXPO_0000925c
obo:TXPO_0001723c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000907c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001804c
obo:RO_0000057op some obo:TXPO_0000775c
Sub-classes obo:TXPO_0000497c
obo:TXPO_0000496c
obo:TXPO_0000498c

hyperfunction of phospholipid synthesis gene expression [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000915
Super-classes obo:TXPO_0001726c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0001176c
obo:RO_0000057op some obo:TXPO_0003261c
obo:RO_0000057op some obo:TXPO_0001171c
obo:TXPO_0000069op some obo:TXPO_0000923c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003530c

hyperfunction of accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000916
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000247c
Sub-classes obo:TXPO_0001365c
obo:TXPO_0003465c

undigested membrane material accumulation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000917
Super-classes obo:TXPO_0001716c
obo:TXPO_0001249c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

increasing number of macrophage derived foam cell [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000918
Super-classes obo:TXPO_0001412c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0004161c
obo:TXPO_0002263c
obo:TXPO_0004154c

lipid homeostasis imbalance (mild) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000919
Super-classes obo:TXPO_0003491c
obo:TXPO_0003488c
Restrictions obo:BFO_0000051op some obo:TXPO_0001039c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0001733op some obo:TXPO_0000493c
obo:TXPO_0000069op some obo:TXPO_0003624c

phospholipid accumulation in lysosome [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000920
Super-classes obo:TXPO_0000910c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000334c
obo:TXPO_0000069op some obo:TXPO_0004010c
obo:TXPO_0000069op some obo:TXPO_0002281c
obo:TXPO_0000069op some obo:TXPO_0001487c
obo:RO_0000086op only obo:TXPO_0000854c
obo:TXPO_0000069op some obo:TXPO_0000921c
obo:TXPO_0000069op some obo:TXPO_0002220c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0004148c
obo:TXPO_0000069op some obo:TXPO_0004001c
obo:TXPO_0000069op some obo:TXPO_0001489c
obo:TXPO_0001873op some obo:TXPO_0003525c
obo:TXPO_0000069op some obo:TXPO_0002094c
obo:TXPO_0000069op some obo:TXPO_0003877c

increasing hepatocellular volume [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000921
Super-classes obo:TXPO_0001716c
obo:TXPO_0000164c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002276c
obo:TXPO_0000774op only obo:TXPO_0002215c

mild accumulation of abnormal proteins in ERc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000922
Super-classes obo:TXPO_0002187c

increasing phospholipid [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000923
Super-classes obo:TXPO_0001716c
obo:TXPO_0001250c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000908c
obo:TXPO_0000774op only obo:TXPO_0003452c

PLA2G2E (human) positively regulator of immune response[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000924
Super-classes obo:TXPO_0000736c
obo:TXPO_0001135c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:RO_0000087op some obo:TXPO_0003572c
obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0002260op some obo:IMR_0000283c

hypofunction of phospholipid degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000925
Super-classes obo:TXPO_0001716c
obo:TXPO_0001253c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0002324c
Sub-classes obo:TXPO_0000914c
obo:TXPO_0003282c
obo:TXPO_0005059c
obo:TXPO_0004162c
obo:TXPO_0002088c
obo:TXPO_0001448c

phagocytosis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000926
Super-classes obo:GO_0006909c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001716c
obo:BFO_0000051op some obo:TXPO_0001298c

cell death [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000927
Super-classes obo:TXPO_0001716c
obo:GO_0008219c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003596c
obo:TXPO_0000069op some obo:TXPO_0001285c
obo:TXPO_0000774op only obo:TXPO_0002215c

positive regulation of apoptotic process [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000928
Super-classes obo:TXPO_0001716c
obo:GO_0043065c
Restrictions obo:BFO_0000051op some obo:TXPO_0001845c
obo:TXPO_0000069op some obo:TXPO_0000927c
obo:TXPO_0000069op some obo:TXPO_0004123c
obo:RO_0000057op some obo:TXPO_0001586c
obo:RO_0000057op some obo:TXPO_0003226c
obo:RO_0000057op some obo:TXPO_0003225c
obo:BFO_0000051op some obo:TXPO_0000664c
obo:BFO_0000051op some obo:TXPO_0001547c
obo:RO_0000057op some obo:TXPO_0003380c
obo:RO_0000057op some obo:TXPO_0003602c
obo:TXPO_0000774op only obo:TXPO_0003452c

sphingomyelin metabolism imbalance in nervous system [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000929
Super-classes obo:TXPO_0001476c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c
obo:TXPO_0000069op some obo:TXPO_0001692c

compound accumulation in lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000930
Super-classes obo:TXPO_0001242c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001551c
obo:RO_0000057op some obo:TXPO_0001425c
obo:RO_0000057op some obo:TXPO_0001566c
obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000069op some obo:TXPO_0000905c
obo:BFO_0000051op some obo:TXPO_0003367c
Sub-classes obo:TXPO_0003454c
obo:TXPO_0003678c
obo:TXPO_0003453c
obo:TXPO_0001695c

troglitazone [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000931
Description

Rifampicin, bosentan, and troglitazone directly inhibit bile salt export pump (BSEP).
Super-classes obo:TXPO_0000749c
obo:CHEBI_9753c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

carbohydrate transport [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000932
Super-classes obo:GO_0008643c

mitochondrial dysfunction [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000933
Super-classes obo:TXPO_0002361c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004218c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0002010c
obo:TXPO_0000069op some obo:TXPO_0002040c
obo:TXPO_0000069op some obo:TXPO_0004263c
obo:TXPO_0000069op some obo:TXPO_0002005c
obo:TXPO_0000069op some obo:TXPO_0004340c
obo:TXPO_0000069op some obo:TXPO_0004272c
obo:TXPO_0000069op some obo:TXPO_0001997c
obo:TXPO_0000069op some obo:TXPO_0004264c

phenobarbital accumulation in liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000934
Super-classes obo:TXPO_0002068c
obo:TXPO_0001234c
Restrictions obo:RO_0000057op some obo:TXPO_0001524c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0001675c
obo:TXPO_0003870c
obo:TXPO_0000966c

constitutive androstane receptor activation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000935
Description

By activating CAR, CAR migrates from the cytoplasm to the nucleus and transcribes the drug metabolizing enzyme Cyp.
Super-classes obo:TXPO_0003855c
obo:TXPO_0001210c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003258c
obo:RO_0002234op some obo:TXPO_0003791c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000937c
obo:TXPO_0001868op some obo:TXPO_0001524c
Sub-classes obo:TXPO_0002309c
obo:TXPO_0003955c

retinoid X receptor activation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000936
Super-classes obo:TXPO_0001214c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000937c

hyperfunction of cytochrome p450 gene expression [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000937
Description

Cyp1a1, Cyp2b1, Cyp4x1
Super-classes obo:TXPO_0001728c
obo:TXPO_0002051c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001621c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0002234op some obo:TXPO_0000990c
obo:RO_0002234op some obo:TXPO_0000991c
Sub-classes obo:TXPO_0003858c

hyperfunction of drug metabolism phase I [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000938
Super-classes obo:TXPO_0001728c
obo:TXPO_0002049c
Restrictions obo:RO_0000057op some obo:TXPO_0000990c
obo:BFO_0000066op some obo:GO_0005790c
obo:TXPO_0000069op some obo:TXPO_0000963c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000943c
obo:RO_0000057op some obo:TXPO_0000991c
Sub-classes obo:TXPO_0001621c
obo:TXPO_0003846c

hyperfunction of iron supply [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000939
Super-classes obo:TXPO_0001237c

hypofunction of decomposingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000940
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000343c
Sub-classes obo:TXPO_0002006c
obo:TXPO_0001376c
obo:TXPO_0000035c
obo:TXPO_0003160c

hyperfunction of electron transport from NADH to cytochrome P450 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000941
Super-classes obo:TXPO_0001728c
obo:TXPO_0002052c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0000995c
obo:TXPO_0000069op some obo:TXPO_0001621c

forming a complex with Cytochrome P450 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000942
Super-classes obo:TXPO_0001212c
obo:TXPO_0001728c
Restrictions obo:RO_0000057op some obo:TXPO_0000992c
obo:TXPO_0000774op only obo:TXPO_0001432c

hyperfunction of drug metabolism phase II [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000943
Super-classes obo:TXPO_0001728c
obo:TXPO_0001236c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000443c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003902c
obo:TXPO_0003849c

AMPK (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000944
Description

PRKAA1
Super-classes obo:TXPO_0000472c
obo:TXPO_0003221c
Restrictions obo:RO_0000087op some obo:TXPO_0001682c
obo:RO_0000086op some obo:PATO_0002354c
obo:TXPO_0002260op some obo:TXPO_0003221c
Sub-classes obo:TXPO_0003957c
obo:TXPO_0003948c
obo:TXPO_0003931c

negative regulation of ATP consuming [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000945
Super-classes obo:TXPO_0003978c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003954c

changing balance of phospholipid metabolism [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000946
Super-classes obo:TXPO_0001263c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000951c
obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0002324c
obo:TXPO_0002293c
obo:TXPO_0001435c

increasing demand for response to oxidative stress [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000947
Super-classes obo:TXPO_0001728c
obo:TXPO_0000102c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002319c
obo:TXPO_0000774op only obo:TXPO_0001432c

reactive oxygen species biosynthetic process [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000948
Super-classes obo:GO_1903409c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000981c
Sub-classes obo:TXPO_0003850c

phospholipidosis via obesec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000949
Super-classes obo:TXPO_0003369c
Restrictions obo:TXPO_0000004op only obo:TXPO_0002241c
obo:BFO_0000051op some obo:TXPO_0001645c
obo:BFO_0000051op some obo:TXPO_0002241c
obo:BFO_0000051op some obo:TXPO_0000950c

overeating [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000950
Super-classes obo:TXPO_0001716c
obo:TXPO_0001541c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004158c
obo:TXPO_0000774op only obo:TXPO_0000949c

changing phospholipid homeostasis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000951
Super-classes obo:TXPO_0000957c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0002273c
obo:TXPO_0000907c
obo:TXPO_0001683c

DNA damage [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000952
Super-classes obo:NCIT_C16507c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000954c

UGT1A1 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000953
Super-classes obo:TXPO_1000395c
obo:TXPO_0000472c

regulation of cell cycle [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000954
Super-classes obo:TXPO_0001728c
obo:GO_0051726c
Restrictions obo:BFO_0000051op some obo:TXPO_0000962c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0000669c
obo:BFO_0000051op some obo:TXPO_0000959c
obo:TXPO_0000069op some obo:TXPO_0002319c

negative regulation of cell junction assembly [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000955
Super-classes obo:TXPO_0001728c
obo:GO_1901889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0001868op some obo:TXPO_0001524c

expcretion of drug metabolite from hepatocyte to bile tube [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000956
Super-classes obo:TXPO_0001728c
obo:TXPO_0003152c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0001868op some obo:TXPO_0001032c

changing phospholipid homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000957
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0000951c

glycogen catabolic process [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000958
Super-classes obo:TXPO_0001728c
obo:GO_0005980c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001797c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003853c

decreasing negative regulator of G1/S transition [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000959
Super-classes obo:TXPO_0002059c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000669c

carbohydrate storagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000960
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_16646c

cell proliferation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000961
Super-classes obo:GO_0008283c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0000986c

cell cycle DNA replication initiation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000962
Super-classes obo:TXPO_0001728c
obo:GO_1902292c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002320c
obo:TXPO_0000774op only obo:TXPO_0001432c

smooth endoplasmic reticulum proliferation in hepatocyte [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000963
Super-classes obo:TXPO_0001230c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000970c
obo:BFO_0000051op some obo:TXPO_0001613c
obo:TXPO_0000069op some obo:TXPO_0000969c
obo:TXPO_0001873op some obo:TXPO_0003522c
obo:BFO_0000051op some obo:TXPO_0001619c
Sub-classes obo:TXPO_0003901c

negative regulation of signal transduction by p53 class mediator [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000964
Super-classes obo:TXPO_0001728c
obo:GO_1901797c
Restrictions obo:RO_0000057op some obo:TXPO_0001004c
obo:TXPO_0000069op some obo:TXPO_0000965c
obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of apoptotic process [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000965
Super-classes obo:TXPO_0001728c
obo:GO_0043066c
Restrictions obo:RO_0000057op some obo:TXPO_0000975c
obo:TXPO_0001868op some obo:TXPO_0000976c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000970c
obo:RO_0000057op some obo:TXPO_0000784c
Sub-classes obo:TXPO_0001926c
obo:TXPO_0002322c

phenobarbital accumulation in liver (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000966
Super-classes obo:TXPO_0000934c
Restrictions obo:RO_0000086op some obo:PATO_0000498c
obo:TXPO_0000774op only obo:TXPO_0001432c

constitutive androstane receptor activation by phenobarbital (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000967
Super-classes obo:TXPO_0002309c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001524c
obo:TXPO_0000069op some obo:TXPO_0001627c
obo:TXPO_0000069op some obo:TXPO_0001052c
obo:BFO_0000051op some obo:TXPO_0003905c
obo:TXPO_0000069op some obo:TXPO_0000965c
obo:TXPO_0000774op only obo:TXPO_0001432c

making existence of foreign substancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000968
Super-classes obo:TXPO_0000380c
Sub-classes obo:TXPO_0001851c

increasing hepatocellular volume [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000969
Super-classes obo:TXPO_0001728c
obo:TXPO_0000164c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000972c
obo:TXPO_0000069op some obo:TXPO_0000973c
obo:RO_0000057op some obo:TXPO_0001000c
obo:TXPO_0000774op only obo:TXPO_0001432c

hepatocyte proliferation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000970
Super-classes obo:GO_0072574c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000973c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000972c
obo:RO_0000057op some obo:TXPO_0000986c
Sub-classes obo:TXPO_0002320c

increasing hepatic vascular lumen area [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000971
Super-classes obo:TXPO_0001728c
obo:TXPO_0001229c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000973c

increasing liver weight [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000972
Super-classes obo:TXPO_0000054c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

increasing volume of liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000973
Super-classes obo:TXPO_0000616c
obo:TXPO_0001728c
Restrictions obo:RO_0000057op some obo:TXPO_0000986c
obo:TXPO_0000774op only obo:TXPO_0001432c

NAPQI [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000974
Description

CHEBI:29132
Super-classes obo:CHEBI_29132c
obo:TXPO_0001921c
Restrictions obo:RO_0000087op some obo:CHEBI_59739c
obo:TXPO_0000774op only obo:TXPO_0000501c

GADD45B (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000975
Super-classes obo:TXPO_1000160c
obo:TXPO_0000472c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c

phenobarbital - apotosis inhibitor [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000976
Super-classes obo:TXPO_0001524c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c

glucose homeostasis imbalance [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000977
Super-classes obo:TXPO_0001728c
obo:TXPO_0001233c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0001001c

hypoxia [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000978
Super-classes obo:TXPO_0001728c
obo:MP_0005039c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0002319c
obo:RO_0000057op some obo:TXPO_0001008c

CYP2B6 (human)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000979
Super-classes obo:TXPO_1000078c
obo:TXPO_0001009c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c

CAR binding [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000980
Super-classes obo:TXPO_0002066c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000967c
obo:RO_0000057op some obo:TXPO_0000986c

positive regulation of mitochondrial membrane permeability [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000981
Super-classes obo:GO_0035794c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000982c

decreasing mitochondrial membrane potential [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000982
Super-classes obo:TXPO_0001728c
obo:TXPO_0001855c
Restrictions obo:BFO_0000066op some obo:GO_0031966c
obo:TXPO_0000069op some obo:TXPO_0001026c
obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of cell proliferation inhibitor expression [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000983
Super-classes obo:TXPO_0002057c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0002320c

ground glass appearance dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000984
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0000560c
obo:TXPO_0000472c
obo:TXPO_0001071c
obo:TXPO_0001009c
obo:TXPO_0000985c

ground glass appearance dependent molecule (rat invivo)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000985
Super-classes obo:TXPO_0000984c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0001008c
obo:TXPO_0000995c
obo:TXPO_0000996c
obo:TXPO_0000992c
obo:TXPO_0001001c
obo:TXPO_0000991c
obo:TXPO_0001000c
obo:TXPO_0000990c
obo:TXPO_0000998c
obo:TXPO_0000599c
obo:TXPO_0001003c
obo:TXPO_0003983c
obo:TXPO_0000997c
obo:TXPO_0000994c

Ctnnb1 (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000986
Super-classes obo:TXPO_1000094c
obo:TXPO_0001071c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
Sub-classes obo:TXPO_0001073c
obo:TXPO_0001072c
obo:TXPO_0001076c

dioxins and dioxin-like compounds accumulation in liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000987
Super-classes obo:TXPO_0002053c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000988c
obo:TXPO_0000774op only obo:TXPO_0001432c

aryl hydrocarbon receptor activation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000988
Description

AhR activity is combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.
Super-classes obo:TXPO_0003855c
obo:TXPO_0001209c
Restrictions obo:RO_0000057op some obo:TXPO_0000989c
obo:TXPO_0000774op only obo:TXPO_0001432c

AHR (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000989
Super-classes obo:TXPO_0000472c
obo:TXPO_1000030c

Cyp2b1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000990
Super-classes obo:TXPO_0000985c
obo:TXPO_1000101c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Cyp1a1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000991
Super-classes obo:TXPO_0000985c
obo:TXPO_1000100c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Ugt2b1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000992
Super-classes obo:TXPO_0000985c
obo:TXPO_1000397c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

insulin receptor signaling pathway [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000993
Super-classes obo:GO_0008286c

Alas1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000994
Super-classes obo:TXPO_1000034c
obo:TXPO_0000985c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Por (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000995
Super-classes obo:TXPO_0000985c
obo:TXPO_1000309c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Gsta3 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000996
Super-classes obo:TXPO_0000985c
obo:TXPO_1000179c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Txnrd1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000997
Super-classes obo:TXPO_1000389c
obo:TXPO_0000985c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Srnx1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000998
Super-classes obo:TXPO_1000364c
obo:TXPO_0000985c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

TGF (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0000999
Super-classes obo:TXPO_0000472c
obo:TXPO_1000370c

Vav2 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001000
Super-classes obo:TXPO_1000401c
obo:TXPO_0000985c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

Aldh1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001001
Super-classes obo:TXPO_0000985c
obo:TXPO_1000035c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

BIP (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001002
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0002385c
obo:TXPO_0004578c

Lmnb1 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001003
Super-classes obo:TXPO_1000230c
obo:TXPO_0000985c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

MDM2 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001004
Super-classes obo:TXPO_0000472c
obo:IMR_0100660c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c

PPARalpha activation [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001005
Super-classes obo:TXPO_0001729c
obo:TXPO_0000013c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000105c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000118c
obo:TXPO_0000069op some obo:TXPO_0000149c
obo:TXPO_0000069op some obo:TXPO_0002047c
obo:RO_0000057op some obo:TXPO_0001328c
obo:RO_0000057op some obo:TXPO_0000122c
obo:RO_0000057op some obo:TXPO_0000121c
Sub-classes obo:TXPO_0001012c
obo:TXPO_0001010c
obo:TXPO_0000125c

cellular senescence [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001006
Super-classes obo:GO_0090398c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

DDB2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001007
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001019c

Ankrd37 (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001008
Super-classes obo:TXPO_0000985c
obo:TXPO_1000036c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

ground glass appearance dependent gene (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001009
Super-classes obo:TXPO_0000984c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
Sub-classes obo:TXPO_0000786c
obo:TXPO_0000979c
obo:TXPO_0003909c
obo:TXPO_0001035c
obo:TXPO_0001032c

PPARalpha activation (moderate) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001010
Super-classes obo:TXPO_0001005c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000118c
obo:TXPO_0000069op some obo:TXPO_0001023c
obo:RO_0000057op some obo:TXPO_0000121c
obo:TXPO_0000069op some obo:TXPO_0002047c
obo:RO_0000057op some obo:TXPO_0001328c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000149c
obo:RO_0000057op some obo:TXPO_0000122c

hypofunction of carbohydrate transport [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001011
Super-classes obo:TXPO_0001728c
obo:TXPO_0002048c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002319c
obo:TXPO_0000716op some obo:TXPO_0000932c
obo:TXPO_0000774op only obo:TXPO_0001432c

PPARalpha activation (mild) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001012
Super-classes obo:TXPO_0001005c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000149c
obo:RO_0000057op some obo:TXPO_0000122c
obo:TXPO_0000069op some obo:TXPO_0001016c
obo:RO_0000057op some obo:TXPO_0001328c
obo:TXPO_0000069op some obo:TXPO_0002047c
obo:RO_0000057op some obo:TXPO_0000121c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000118c

tumorigenesis [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001013
Description

Phenobarbital does not increase the liver tumors in humans.
Super-classes obo:TXPO_0001728c
obo:NCIT_C18121c
Restrictions obo:RO_0000057op some obo:TXPO_0000986c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:BFO_0000051op some obo:TXPO_0001030c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0001028c
obo:BFO_0000051op some obo:TXPO_0002319c
obo:RO_0000057op some obo:TXPO_0001019c

GOT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001014
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001021c
Sub-classes obo:TXPO_0001017c

RNA splicing [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001015
Super-classes obo:GO_0008380c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

peroxisomal proliferation in hepatocyte (mild) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001016
Description

Humans do not respond with hepatocellular and peroxisomal proliferation to fibrates and express PPARalpha at low levels and often in nonfunctional forms.

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
Super-classes obo:TXPO_0000105c
()
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0002027c
obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:RO_0000057op some obo:TXPO_0001045c
obo:TXPO_0001873op some obo:TXPO_0003535c

GOT1 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001017
Super-classes obo:TXPO_0003516c
obo:TXPO_0001014c
Restrictions obo:RO_0000087op some obo:TXPO_0001021c

negative regulation of autophagy [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001018
Super-classes obo:GO_0010507c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0002323c

DDB2 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001019
Super-classes obo:TXPO_0000472c
obo:TXPO_0001007c
Restrictions obo:RO_0000087op some obo:TXPO_0001561c
Sub-classes obo:TXPO_0001939c

ARID5A [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001020
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001035c

aspartate transaminasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001021
Super-classes obo:TXPO_0000606c

GPT (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001022
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001027c
Sub-classes obo:TXPO_0001024c

peroxisomal proliferation in hepatocyte (moderate) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001023
Description

Humans do not respond with hepatocellular and peroxisomal proliferation to fibrates and express PPARalpha at low levels and often in nonfunctional forms.

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
Super-classes obo:TXPO_0000105c
()
Restrictions obo:TXPO_0001873op some obo:TXPO_0003536c
obo:RO_0000057op some obo:TXPO_0001045c
obo:TXPO_0000069op some obo:TXPO_0002025c
obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:TXPO_0000774op only obo:TXPO_0000028c

GPT (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001024
Super-classes obo:TXPO_0003516c
obo:TXPO_0001022c
Restrictions obo:RO_0000087op some obo:TXPO_0001027c

peroxisomal proliferation in hepatocyte (severe) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001025
Description

Humans do not respond with hepatocellular and peroxisomal proliferation to fibrates and express PPARalpha at low levels and often in nonfunctional forms.

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
Super-classes ()
obo:TXPO_0000105c
Restrictions obo:TXPO_0001873op some obo:TXPO_0003537c
obo:RO_0000057op some obo:TXPO_0001045c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0002029c
obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:TXPO_0000069op some obo:TXPO_0000127c

apoptotic process [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001026
Super-classes obo:GO_0006915c
obo:TXPO_0001728c
Restrictions obo:BFO_0000051op some obo:TXPO_0000781c
obo:RO_0000057op some obo:TXPO_0000777c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0000314c

Alanine transaminasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001027
Super-classes obo:TXPO_0000606c

tumor growth [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001028
Super-classes obo:TXPO_0001728c
()
obo:TXPO_0000766c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0001524c
obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:RO_0000057op some obo:TXPO_0003983c

increasing demand for response to mitochondrial oxidative stress [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001029
Super-classes obo:TXPO_0002301c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004269c
obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000069op some obo:TXPO_0004342c
obo:TXPO_0000069op some obo:TXPO_0004343c
obo:BFO_0000051op some obo:TXPO_0001990c
obo:TXPO_0000069op some obo:TXPO_0004344c
obo:TXPO_0000069op some obo:TXPO_0004341c

tumor cell proliferation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001030
Super-classes obo:TXPO_0000339c
()
obo:TXPO_0001728c
Restrictions obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000597c

increasing number of dead cells in liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001031
Super-classes obo:TXPO_0000341c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000597c
obo:TXPO_0000069op some obo:TXPO_0003597c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0001432c

MRP2 (human)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001032
Super-classes obo:TXPO_0002496c
obo:TXPO_0001009c

metastasis [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001033
Super-classes obo:TXPO_0001728c
obo:NCIT_C19151c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001030c

eosinogranular degeneration dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001034
Super-classes obo:TXPO_0000835c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
Sub-classes obo:TXPO_0003255c
obo:TXPO_0003246c
obo:TXPO_0000649c
obo:TXPO_0001037c
obo:TXPO_0003253c
obo:TXPO_0001046c
obo:TXPO_0001069c
obo:TXPO_0001084c
obo:TXPO_0003249c

ARID5A (human)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001035
Super-classes obo:TXPO_0001009c
obo:TXPO_0001020c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c

hypofunction of fatty acid degradation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001036
Super-classes obo:TXPO_0001720c
obo:TXPO_0002147c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000051op some obo:TXPO_0000901c
obo:TXPO_0000069op some obo:TXPO_0000893c
Sub-classes obo:TXPO_0003361c

PTPN4 (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001037
Super-classes obo:TXPO_1000293c
obo:TXPO_0001034c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c
obo:TXPO_0000819op some obo:OGG_3000005775c

lipid homeostasis imbalance (severe) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001038
Super-classes obo:TXPO_0003491c
obo:TXPO_0003488c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003476c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0001733op some (obo:TXPO_0000679c or obo:TXPO_0001779c)
obo:BFO_0000051op some obo:TXPO_0001044c
Sub-classes obo:TXPO_0004209c

lipid metabolism imbalance (mild) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001039
Super-classes obo:TXPO_0000893c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0000919c

lipid metabolism imbalance (moderate) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001040
Super-classes obo:TXPO_0000893c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001043c

alcoholic fatty liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001041
Description

under construction
Super-classes obo:TXPO_0000888c
Restrictions obo:BFO_0000051op some obo:TXPO_0001259c
obo:BFO_0000051op some obo:TXPO_0001130c
obo:BFO_0000051op some obo:TXPO_0004210c
obo:BFO_0000051op some obo:TXPO_0004207c
obo:BFO_0000051op some obo:TXPO_0004209c
obo:BFO_0000051op some obo:TXPO_0001150c
obo:BFO_0000051op some obo:TXPO_0000279c
obo:BFO_0000051op some obo:TXPO_0001131c
obo:BFO_0000051op some obo:TXPO_0001246c
obo:BFO_0000051op some obo:TXPO_0001132c
obo:BFO_0000051op some obo:TXPO_0001118c
obo:BFO_0000051op some obo:TXPO_0002357c

lipid accumulation in hepatocyte (moderate) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001042
Super-classes obo:TXPO_0001129c
Restrictions obo:BFO_0000051op some obo:TXPO_0001521c
obo:TXPO_0001873op some obo:TXPO_0003540c
obo:TXPO_0000069op some obo:TXPO_0003478c
obo:TXPO_0000774op only obo:TXPO_0000888c

lipid homeostasis imbalance (moderate) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001043
Super-classes obo:TXPO_0003491c
obo:TXPO_0003488c
Restrictions obo:BFO_0000051op some obo:TXPO_0001040c
obo:TXPO_0001733op some obo:TXPO_0000680c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001042c

lipid metabolism imbalance (severe) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001044
Super-classes obo:TXPO_0000893c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001038c
Sub-classes obo:TXPO_0004207c

Pex11a (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001045
Super-classes obo:TXPO_1000278c
obo:TXPO_0000648c
Restrictions obo:RO_0000087op some obo:TXPO_0002350c
obo:TXPO_0000756op some obo:TXPO_0000489c

ACOT4 (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001046
Super-classes obo:TXPO_1000024c
obo:TXPO_0001034c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

Elovl6 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001047
Super-classes obo:TXPO_0001077c
obo:TXPO_1000125c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Hsdl2 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001048
Super-classes obo:TXPO_0001077c
obo:TXPO_1000198c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

moving fatty acid to the hepatocyte [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001049
Super-classes obo:TXPO_0001466c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c

CPT1 (canonical)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001050
Super-classes obo:TXPO_1000097c
obo:TXPO_0001280c

Mgll (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001051
Super-classes obo:TXPO_1000245c
obo:TXPO_0001077c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

negative regulation of cellular senescence [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001052
Super-classes obo:GO_2000773c
obo:TXPO_0001728c
Restrictions obo:RO_0002212op some obo:TXPO_0001006c
obo:RO_0000057op some obo:TXPO_0001076c
obo:BFO_0000066op some obo:NCBITaxon_10090c
obo:RO_0000057op some obo:TXPO_0001543c
obo:TXPO_0000774op only obo:TXPO_0001432c

Cyp4a3 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001053
Super-classes obo:TXPO_1000108c
obo:TXPO_0001077c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

non-membrane spanning protein tyrosine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001054
Description

related molecular function GO:0004715
Super-classes obo:TXPO_0002292c

Plin2 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001055
Super-classes obo:TXPO_0000648c
obo:TXPO_1000286c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

decreasing lipid [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001056
Super-classes obo:TXPO_0001720c
obo:TXPO_0000644c
Restrictions obo:BFO_0000051op some obo:TXPO_0001379c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:BFO_0000051op some obo:TXPO_0001220c
obo:BFO_0000051op some obo:TXPO_0001221c
obo:BFO_0000051op some obo:TXPO_0001174c

Acot3 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001057
Super-classes obo:TXPO_0000648c
obo:TXPO_1000023c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Acot2 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001058
Super-classes obo:TXPO_0000648c
obo:TXPO_1000022c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

increasing lipid [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001059
Super-classes obo:TXPO_0001720c
obo:TXPO_0001062c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000051op some obo:TXPO_0001153c
obo:BFO_0000051op some obo:TXPO_0001267c
obo:BFO_0000051op some obo:TXPO_0001141c
obo:BFO_0000051op some obo:TXPO_0001386c
obo:BFO_0000051op some obo:TXPO_0001078c

Acox1 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001060
Super-classes obo:TXPO_1000027c
obo:TXPO_0001077c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Ehhadh (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001061
Super-classes obo:TXPO_0001077c
obo:TXPO_1000131c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

increasing lipidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001062
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0005056c
obo:TXPO_0004954c
obo:TXPO_0005038c
obo:TXPO_0001059c

IL-1beta processingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001063
Super-classes obo:GO_0016485c
Sub-classes obo:TXPO_0001065c

Cpt2 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001064
Super-classes obo:TXPO_0001077c
obo:TXPO_1000098c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

IL-1beta processing [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001065
Super-classes obo:TXPO_0001720c
obo:TXPO_0001063c
Restrictions obo:RO_0002234op some obo:TXPO_0001875c
obo:TXPO_0000069op some obo:TXPO_0001878c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0001868op some obo:TXPO_0001079c

Slc25a20 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001066
Super-classes obo:TXPO_1000360c
obo:TXPO_0001077c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Acot12 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001067
Super-classes obo:TXPO_1000021c
obo:TXPO_0001077c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Acot7 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001068
Super-classes obo:TXPO_0001077c
obo:TXPO_1000025c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

ACOT8 (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001069
Super-classes obo:TXPO_0001034c
obo:TXPO_1000026c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

Hadhb (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001070
Super-classes obo:TXPO_1000193c
obo:TXPO_0001077c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

ground glass appearance dependent molecule (mouse)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001071
Super-classes obo:TXPO_0000984c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10090c
Sub-classes obo:TXPO_0003908c
obo:TXPO_0003263c
obo:TXPO_0000986c
obo:TXPO_0000777c
obo:TXPO_0003907c

Ctnnb1 -tumor positive regulator (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001072
Super-classes obo:TXPO_0000986c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0002271c

Ctnnb1 -apoptosis inhibitor (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001073
Super-classes obo:TXPO_0000986c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:CHEBI_68494c

Acaa1a (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001074
Super-classes obo:TXPO_0001077c
obo:TXPO_1000017c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

increasing lipid materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001075
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0001078c
obo:TXPO_0001314c

Ctnnb1 -cell senescence inhibitor (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001076
Super-classes obo:TXPO_0000986c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0001139c

eosinogranular degeneration dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001077
Super-classes obo:TXPO_0000835c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0001051c
obo:TXPO_0001070c
obo:TXPO_0001067c
obo:TXPO_0001048c
obo:TXPO_0001066c
obo:TXPO_0001047c
obo:TXPO_0001074c
obo:TXPO_0001053c
obo:TXPO_0001061c
obo:TXPO_0001064c
obo:TXPO_0001081c
obo:TXPO_0001060c
obo:TXPO_0001068c

increasing lipid material [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001078
Super-classes obo:TXPO_0001075c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001141c

CASP1 -IL1beta activator (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001079
Super-classes obo:TXPO_0001104c
obo:IMR_0100302c
Restrictions obo:RO_0000087op some obo:TXPO_0001080c

IL-1b activator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001080
Super-classes obo:TXPO_0003714c

Cyp4a1 (rat)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001081
Super-classes obo:TXPO_1000107c
obo:TXPO_0001077c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

cellular senescence regulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001082
Super-classes obo:TXPO_0003230c
Sub-classes obo:TXPO_0001139c

positive regulation of mitochondrial membrane permeability [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001083
Super-classes obo:TXPO_0001720c
obo:GO_0035794c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001127c
obo:TXPO_0000069op some obo:TXPO_0004128c
obo:TXPO_0000069op some obo:TXPO_0001085c

PLIN2 (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001084
Super-classes obo:TXPO_1000286c
obo:TXPO_0001034c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000123c
obo:TXPO_0000756op some obo:TXPO_0000795c
obo:TXPO_0000756op some ncicp:C15958c

decreasing mitochondrial membrane potential [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001085
Super-classes obo:TXPO_0001720c
obo:TXPO_0001855c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001540c
obo:BFO_0000066op some obo:GO_0031966c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0001749c

reactive oxygen species biosynthetic process [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001086
Super-classes obo:GO_1903409c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001127c
obo:TXPO_0000069op some obo:TXPO_0001083c
obo:TXPO_0000069op some obo:TXPO_0003510c

apoptosis [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001087
Super-classes obo:GO_0006915c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c

lipidosis dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001088
Super-classes obo:TXPO_0001089c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0001226c
obo:TXPO_0001405c

lipidosis dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001089
Super-classes obo:TXPO_0001731c
Sub-classes obo:TXPO_0003516c
obo:TXPO_0001105c
obo:TXPO_0001090c
obo:TXPO_0001088c
obo:TXPO_0003508c

lipidosis dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001090
Super-classes obo:TXPO_0001089c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
Sub-classes obo:TXPO_0001093c
obo:TXPO_0001786c
obo:TXPO_0001091c
obo:TXPO_0001774c
obo:TXPO_0001097c
obo:TXPO_0001103c

ADH1B (human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001091
Description

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis.
Super-classes obo:TXPO_0001090c
obo:TXPO_0001092c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000000125c

ADH1B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001092
Super-classes obo:TXPO_0001094c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000125c
Sub-classes obo:TXPO_0004007c
obo:TXPO_0001091c

BID (human)[Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001093
Super-classes obo:TXPO_0001090c
obo:IMR_0100289c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

ADH familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001094
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004011c
obo:TXPO_0004012c
obo:TXPO_0001092c

hyporfunction of alcohol metabolism [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001095
Super-classes obo:TXPO_0001096c
obo:TXPO_0001720c
Restrictions obo:RO_0000057op some obo:TXPO_0001091c
obo:TXPO_0000069op some obo:TXPO_0001739c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:RO_0000057op some obo:TXPO_0004007c

hypofunction of alcohol metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001096
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0006066c
Sub-classes obo:TXPO_0001095c

BAD (human)[Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001097
Super-classes obo:TXPO_0001090c
obo:IMR_0100288c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

OXTR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001098
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005021c
Sub-classes obo:TXPO_0001099c

OXTR (human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001099
Super-classes obo:TXPO_0001786c
obo:TXPO_0001098c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000005021c

fatty acid beta-oxidation in adipose tissue [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001100
Super-classes obo:TXPO_0001720c
obo:GO_0006635c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000066op some obo:UBERON_0001013c

increasing free fatty acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001101
Super-classes obo:TXPO_0000395c

CMPK2 (human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001102
Super-classes obo:TXPO_0001106c
obo:TXPO_0001786c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000129607c
obo:TXPO_0000756op some ncicp:C15958c

USF2 (human)[Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001103
Super-classes obo:TXPO_1000396c
obo:TXPO_0001090c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

CASP1 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001104
Super-classes obo:IMR_0100302c
obo:TXPO_0003516c
Sub-classes obo:TXPO_0001079c

Lipidosis dependent molecule (mouse)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001105
Super-classes obo:TXPO_0001089c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
Sub-classes obo:TXPO_0001252c
obo:TXPO_0004003c

CMPK2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001106
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000129607c
Sub-classes obo:TXPO_0001102c

inflammasome activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001107
Super-classes obo:TXPO_0000401c
Restrictions obo:RO_0002234op some (obo:GO_0061702c and ub744bL56361C17c)
Sub-classes obo:TXPO_0001744c
obo:TXPO_0000844c
obo:TXPO_0004380c
obo:TXPO_0003825c

USF1 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001108
Super-classes obo:TXPO_0003516c
obo:TXPO_0001110c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

insulin(canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001109
Super-classes obo:IMR_0000052c
obo:TXPO_0003516c

USF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001110
Super-classes obo:TXPO_0001111c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007392c
Sub-classes obo:TXPO_0001108c

USF (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001111
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_1000396c
obo:TXPO_0001110c

USF1 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001112
Super-classes obo:TXPO_0000124c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000899c
Sub-classes obo:TXPO_0001113c

USF1 activation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001113
Super-classes obo:TXPO_0001112c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0002234op some obo:TXPO_0001108c

SREBP activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001114
Super-classes obo:TXPO_0000124c
Restrictions obo:RO_0002234op some (obo:TXPO_0003966c and ub744bL56439C17c)
Sub-classes obo:TXPO_0001115c

SREBP activation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001115
Super-classes obo:TXPO_0001720c
obo:TXPO_0001114c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000899c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0002234op some obo:TXPO_0003812c

malfunctioning of insulin signaling [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001116
Super-classes obo:TXPO_0001125c
obo:TXPO_0001720c
Restrictions obo:BFO_0000051op some obo:TXPO_0001115c
obo:TXPO_0000069op some obo:TXPO_0001117c
obo:TXPO_0000069op some obo:TXPO_0001113c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0000057op some obo:TXPO_0001109c

LXRa activation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001117
Super-classes obo:TXPO_0000411c
obo:TXPO_0001720c
Restrictions obo:RO_0000057op some obo:TXPO_0001119c
obo:TXPO_0000069op some obo:TXPO_0001115c
obo:TXPO_0000069op some obo:TXPO_0001121c
obo:TXPO_0000069op some obo:TXPO_0000899c
obo:TXPO_0000069op some obo:TXPO_0001284c
obo:TXPO_0000774op only obo:TXPO_0001155c

increasing NAD/NAD+ ratio [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001118
Super-classes obo:TXPO_0001292c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001130c
obo:TXPO_0000774op only obo:TXPO_0001041c

LXRA (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001119
Super-classes obo:TXPO_0001120c
obo:TXPO_0003516c

LXRa (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001120
Super-classes obo:TXPO_0001509c
Sub-classes obo:TXPO_0001119c

ChREBP activation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001121
Super-classes obo:TXPO_0001720c
obo:TXPO_0000051c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000899c
obo:RO_0000057op some obo:TXPO_0001123c
obo:TXPO_0000774op only obo:TXPO_0001155c

organophosphatec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001122
Super-classes obo:CHEBI_72695c
Sub-classes obo:IMR_0001385c

CHREBP (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001123
Super-classes obo:TXPO_0001124c
obo:TXPO_0003516c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

CHREBP (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001124
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:TXPO_0001123c

malfunctioning of insulin signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001125
Super-classes obo:TXPO_0001453c
Sub-classes obo:TXPO_0001116c
obo:TXPO_0004379c
obo:TXPO_0004088c

dysfunction of peroxisomal fatty acid beta-oxidation [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001126
Super-classes obo:TXPO_0001720c
obo:TXPO_0003629c
obo:TXPO_0003652c
Restrictions obo:BFO_0000066op some obo:GO_0005777c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0003361c

non-alcoholic steatohepatitis (toxic course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001127
Super-classes obo:TXPO_0003498c
Restrictions obo:BFO_0000051op some obo:TXPO_0001856c
obo:TXPO_0000004op some obo:TXPO_0003476c
obo:BFO_0000051op some obo:TXPO_0000050c
obo:BFO_0000051op some obo:TXPO_0003622c
obo:BFO_0000051op some obo:TXPO_0000890c
obo:BFO_0000051op some obo:TXPO_0001115c
obo:BFO_0000051op some obo:TXPO_0003810c
obo:BFO_0000051op some obo:TXPO_0001086c
obo:BFO_0000051op some obo:TXPO_0001038c
obo:BFO_0000051op some obo:TXPO_0000899c
obo:BFO_0000051op some obo:TXPO_0001044c
obo:BFO_0000051op some obo:TXPO_0000898c
obo:BFO_0000051op some obo:TXPO_0003507c
obo:BFO_0000051op some obo:TXPO_0003806c
obo:BFO_0000051op some obo:TXPO_0001864c
obo:BFO_0000051op some obo:TXPO_0003484c
obo:BFO_0000051op some obo:TXPO_0003478c
obo:BFO_0000051op some obo:TXPO_0000891c
obo:BFO_0000051op some obo:TXPO_0004128c
obo:BFO_0000051op some obo:TXPO_0001116c
obo:BFO_0000051op some obo:TXPO_0001085c
obo:BFO_0000051op some obo:TXPO_0001117c
obo:BFO_0000051op some obo:TXPO_0001113c
obo:BFO_0000051op some obo:TXPO_0001121c
obo:BFO_0000051op some obo:TXPO_0001882c
obo:BFO_0000051op some obo:TXPO_0001894c
obo:BFO_0000051op some obo:TXPO_0001858c
obo:BFO_0000051op some obo:TXPO_0003620c
obo:BFO_0000051op some obo:TXPO_0000809c
obo:BFO_0000051op some obo:TXPO_0003756c
obo:BFO_0000051op some obo:TXPO_0003621c
obo:BFO_0000051op some obo:TXPO_0001618c
obo:BFO_0000051op some obo:TXPO_0003808c
obo:BFO_0000051op some obo:TXPO_0001083c
obo:BFO_0000051op some obo:TXPO_0003510c
obo:BFO_0000051op some obo:TXPO_0003480c
obo:BFO_0000051op some obo:TXPO_0003807c
obo:BFO_0000051op some obo:TXPO_0003495c
obo:BFO_0000051op some obo:TXPO_0003811c
obo:BFO_0000051op some obo:TXPO_0001539c
obo:BFO_0000051op some obo:TXPO_0001095c
obo:BFO_0000051op some obo:TXPO_0003809c
obo:BFO_0000051op some obo:TXPO_0003482c
obo:BFO_0000051op some obo:TXPO_0003361c
obo:BFO_0000051op some obo:TXPO_0003476c
obo:BFO_0000051op some obo:TXPO_0003512c
obo:BFO_0000051op some obo:TXPO_0003799c
obo:BFO_0000051op some obo:TXPO_0001126c

simple steatosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001128
Super-classes obo:TXPO_0003498c
Restrictions obo:BFO_0000051op some obo:TXPO_0003507c
obo:BFO_0000051op some obo:TXPO_0003806c
obo:BFO_0000051op some obo:TXPO_0003624c
obo:BFO_0000051op some obo:TXPO_0003809c
obo:BFO_0000051op some obo:TXPO_0003482c
obo:BFO_0000051op some obo:TXPO_0001039c
obo:BFO_0000051op some obo:TXPO_0000898c
obo:BFO_0000051op some obo:TXPO_0003811c
obo:BFO_0000051op some obo:TXPO_0000919c
obo:TXPO_0000004op some obo:TXPO_0003624c
obo:BFO_0000051op some obo:TXPO_0000901c
obo:BFO_0000051op some obo:TXPO_0003807c
obo:BFO_0000051op some obo:TXPO_0001121c
obo:BFO_0000051op some obo:TXPO_0003808c
obo:BFO_0000051op some obo:TXPO_0003484c
obo:BFO_0000051op some obo:TXPO_0003810c
obo:BFO_0000051op some obo:TXPO_0000890c
obo:BFO_0000051op some obo:TXPO_0000891c
obo:BFO_0000051op some obo:TXPO_0000899c

lipid strorage in hepatocyte [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001129
Super-classes obo:TXPO_0001720c
obo:TXPO_0003623c
Restrictions obo:BFO_0000051op some obo:TXPO_0001522c
obo:TXPO_0001873op some obo:TXPO_0003499c
obo:TXPO_0000774op only obo:TXPO_0000888c
Sub-classes obo:TXPO_0003476c
obo:TXPO_0003624c
obo:TXPO_0001042c

malfunctioning of TCA cycle [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001130
Super-classes obo:TXPO_0001269c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001749c
obo:TXPO_0000069op some obo:TXPO_0001748c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0001131c

acetyl CoA increase [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001131
Super-classes obo:TXPO_0001720c
obo:TXPO_0000088c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001739c
obo:TXPO_0000774op only obo:TXPO_0001155c

Increasing production amount of acetaldehyde [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001132
Super-classes obo:TXPO_0001720c
obo:TXPO_0001409c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001130c
obo:TXPO_0000069op some obo:TXPO_0002357c
obo:TXPO_0000774op only obo:TXPO_0001155c

phospholipidosis dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001133
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0001134c
obo:TXPO_0001135c
obo:TXPO_0001849c
obo:TXPO_0003213c
obo:TXPO_0003278c

phospholipidosis dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001134
Super-classes obo:TXPO_0001133c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0001176c
obo:TXPO_0001171c
obo:TXPO_0001452c
obo:TXPO_0001159c
obo:TXPO_0001158c
obo:TXPO_0001173c
obo:TXPO_0001175c
obo:TXPO_0001151c

phospholipidosis dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001135
Super-classes obo:TXPO_0001133c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
obo:TXPO_0000756op some ncicp:C15958c
Sub-classes obo:TXPO_0002579c
obo:TXPO_0001138c
obo:TXPO_0004149c
obo:TXPO_0001563c
obo:TXPO_0001140c
obo:TXPO_0002668c
obo:TXPO_0001532c
obo:TXPO_0003894c
obo:TXPO_0003558c
obo:TXPO_0003559c
obo:TXPO_0001137c
obo:TXPO_0001142c
obo:TXPO_0001136c
obo:TXPO_0003941c
obo:TXPO_0001903c
obo:TXPO_0003574c
obo:TXPO_0004087c
obo:TXPO_0004095c
obo:TXPO_0000924c
obo:TXPO_0003900c
obo:TXPO_0003893c
obo:TXPO_0001789c
obo:TXPO_0000659c
obo:TXPO_0001549c
obo:TXPO_0002090c
obo:TXPO_0003560c
obo:TXPO_0003582c
obo:TXPO_0004050c
obo:TXPO_0004052c
obo:TXPO_0003788c
obo:TXPO_0004106c
obo:TXPO_0004105c
obo:TXPO_0003573c
obo:TXPO_0004070c
obo:TXPO_0004086c
obo:TXPO_0001143c
obo:TXPO_0004112c
obo:TXPO_0001859c
obo:TXPO_0003280c
obo:TXPO_0000077c
obo:TXPO_0000078c
obo:TXPO_0003586c
obo:TXPO_0004118c
obo:TXPO_0001568c

SLC44A2 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001136
Super-classes obo:TXPO_0001135c
obo:TXPO_1000344c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:TXPO_0001307c
obo:TXPO_0000819op some obo:OGG_3000057153c

GAB1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001137
Super-classes obo:IMR_0001410c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:TXPO_0002271c
obo:RO_0000056op some obo:TXPO_0001490c
obo:TXPO_0000819op some obo:OGG_3000002549c
obo:TXPO_0002260op some obo:IMR_0001409c
obo:RO_0000056op some obo:TXPO_0001491c

PLB1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001138
Super-classes obo:TXPO_0001135c
obo:TXPO_1000284c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0000819op some obo:OGG_3000151056c
obo:TXPO_0000756op some ncicp:C15958c

cellular senescence inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001139
Super-classes obo:TXPO_0001082c

FGF18 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001140
Super-classes obo:TXPO_0001135c
obo:TXPO_1000142c
Restrictions obo:RO_0000087op some obo:TXPO_0002272c
obo:RO_0000056op some obo:TXPO_0000841c
obo:RO_0000056op some obo:TXPO_0000836c
obo:TXPO_0000756op some obo:TXPO_0000795c
obo:RO_0000056op some obo:TXPO_0001491c
obo:TXPO_0000819op some obo:OGG_3000008817c
obo:RO_0000056op some obo:TXPO_0001490c

lipid biosynthetic process [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001141
Super-classes obo:TXPO_0001720c
obo:GO_0008610c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001157c
obo:BFO_0000066op some obo:UBERON_0002107c

PLA2G5 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001142
Super-classes obo:TXPO_0001135c
obo:TXPO_1000283c
Restrictions obo:TXPO_0002260op some obo:IMR_0000283c
obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:TXPO_0002289c
obo:TXPO_0000819op some obo:OGG_3000005322c
obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:TXPO_0002290c

IL2RB (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001143
Super-classes obo:TXPO_1000202c
obo:TXPO_0001135c
Restrictions obo:TXPO_0002260op some obo:IMR_0000096c
obo:RO_0000087op some obo:TXPO_0003331c
obo:RO_0000056op some obo:TXPO_0001488c
obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000003560c
obo:RO_0000056op some obo:TXPO_0000833c
Sub-classes obo:TXPO_0002268c
obo:TXPO_0002267c
obo:TXPO_0003408c

carboxylic acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001144
Super-classes obo:CHEBI_72695c
Sub-classes obo:TXPO_0001222c
obo:TXPO_0000834c

caspase-3c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001145
Super-classes obo:IMR_0000306c
Sub-classes obo:TXPO_0004879c
obo:TXPO_0003205c
obo:TXPO_0003273c
obo:TXPO_0004055c
obo:TXPO_0003166c

ACOT familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001146
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_1000024c
obo:TXPO_1000026c
obo:TXPO_0003252c
obo:TXPO_1000023c
obo:TXPO_1000021c
obo:TXPO_0000868c
obo:TXPO_1000022c
obo:TXPO_0002018c
obo:TXPO_1000025c

proteasome inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001147
Super-classes obo:TXPO_0003713c

ACERc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001148
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_1000019c
obo:TXPO_1000020c

negative regulation of apoptotic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001149
Super-classes obo:TXPO_0000889c
obo:GO_0043066c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003209c
obo:TXPO_0000774op only obo:TXPO_0000501c

hyperfunction of alcohol metabolism [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001150
Super-classes obo:TXPO_0001272c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001132c
obo:TXPO_0000069op some obo:TXPO_0001246c

Sgpl1 (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001151
Super-classes obo:TXPO_0001134c
obo:TXPO_0000014c
Sub-classes obo:TXPO_0003261c

unsaturated fatty acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001152
Super-classes obo:TXPO_0000834c
Sub-classes obo:TXPO_0001166c

positive regulation of lipid biosynthetic process [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001153
Super-classes obo:TXPO_0001720c
obo:GO_0046889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

lipidosis (normal course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001154
Super-classes obo:TXPO_0001155c
Restrictions obo:BFO_0000051op some obo:TXPO_0001170c
obo:BFO_0000051op some obo:TXPO_0001157c
obo:TXPO_0000004op some obo:TXPO_0001170c
obo:BFO_0000051op some obo:TXPO_0001168c

lipidosis (course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001155
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0001163c
obo:TXPO_0000004op some obo:TXPO_0001160c
obo:BFO_0000051op some obo:TXPO_0001160c
Sub-classes obo:TXPO_0000888c
obo:TXPO_0001154c

keeping lipid metaolism balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001156
Super-classes obo:TXPO_0000682c
Sub-classes obo:TXPO_0001157c

maintaining lipid metabolism balance [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001157
Super-classes obo:TXPO_0001160c
obo:TXPO_0001156c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001168c
obo:TXPO_0000774op only obo:TXPO_0001154c
obo:TXPO_0001733op some obo:TXPO_0002076c

Gadd45a (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001158
Super-classes obo:TXPO_1000174c
obo:TXPO_0001134c
Restrictions obo:RO_0000087op some obo:TXPO_0002270c
obo:RO_0000056op some obo:TXPO_0001850c
obo:RO_0000056op some obo:TXPO_0001489c
obo:RO_0000056op some obo:TXPO_0001488c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000056op some obo:TXPO_0001547c
Sub-classes obo:TXPO_0002249c
obo:TXPO_0002251c

Cyp2b1 (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001159
Super-classes obo:TXPO_1000101c
obo:TXPO_0001134c
Restrictions obo:TXPO_0002260op some obo:TXPO_0001553c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0002262c

changing balance of lipid metabolism [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001160
Super-classes obo:TXPO_0001161c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001163c
obo:TXPO_0000774op only obo:TXPO_0001155c
Sub-classes obo:TXPO_0001157c
obo:TXPO_0000893c

changing balance of lipid metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001161
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0001160c

changing lipid homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001162
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0001163c

changing lipid homeostasis [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001163
Super-classes obo:TXPO_0001720c
obo:TXPO_0001162c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
Sub-classes obo:TXPO_0003491c
obo:TXPO_0001168c

maintaining lipid homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001164
Super-classes obo:GO_0042592c
Sub-classes obo:TXPO_0001168c

ATP degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001165
Super-classes obo:GO_0009056c
Restrictions obo:RO_0002233op some obo:CHEBI_15422c

arachidonic acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001166
Super-classes obo:TXPO_0001152c

cholesterol transport gene mutationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001167
Super-classes obo:TXPO_0001985c
Sub-classes obo:TXPO_0001557c

maintaining lipid homeostasis [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001168
Super-classes obo:TXPO_0001164c
obo:TXPO_0001163c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c

keeping amount of lipid in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001169
Super-classes obo:TXPO_0000414c
Sub-classes obo:TXPO_0001170c

keeping amount of lipid in liver [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001170
Super-classes obo:TXPO_0001169c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001168c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:BFO_0000051op some obo:TXPO_0001056c
obo:BFO_0000051op some obo:TXPO_0001059c

Etnk2 (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001171
Super-classes obo:TXPO_0001134c
obo:TXPO_1000136c
Restrictions obo:RO_0000056op some obo:TXPO_0000915c
obo:RO_0000087op some obo:TXPO_0002362c
obo:TXPO_0000756op some obo:TXPO_0000489c

KEAP1 [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001172
Super-classes obo:TXPO_0002045c
obo:TXPO_0000877c

Cyp2c6v1 (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001173
Super-classes obo:TXPO_0001134c
obo:TXPO_1000103c
Restrictions obo:RO_0000087op some obo:TXPO_0002262c
obo:TXPO_0002260op some obo:TXPO_0001553c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000056op some obo:TXPO_0001551c

positive regulation of lipid catabolic process [lipidosis - normal]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001174
Super-classes obo:GO_0050996c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:BFO_0000051op some obo:TXPO_0001218c

Faah (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001175
Super-classes obo:TXPO_0001134c
obo:TXPO_1000152c
Restrictions obo:RO_0000056op some obo:TXPO_0001495c
obo:RO_0000087op some obo:TXPO_0002272c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000056op some obo:TXPO_0001493c
obo:RO_0000056op some obo:TXPO_0001796c
obo:TXPO_0002260op some obo:TXPO_0001544c
obo:RO_0000056op some obo:TXPO_0001491c

Lpgat1 (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001176
Super-classes obo:TXPO_0001308c
obo:TXPO_0001134c
obo:TXPO_1000231c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Cholesterol homeostasis imbalance [Niemann-Pick C]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001177
Super-classes obo:TXPO_0003491c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0001733op some obo:TXPO_0002327c
obo:TXPO_0000069op some obo:TXPO_0001538c

increasing drug metabolite [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001178
Super-classes obo:TXPO_0000889c
obo:TXPO_0002364c
Restrictions obo:BFO_0000051op some obo:TXPO_0001184c
obo:TXPO_0000774op only obo:TXPO_0000501c

compound accumulation in liver [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001179
Super-classes obo:TXPO_0000889c
obo:TXPO_0001694c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001180c
obo:TXPO_0000774op only obo:TXPO_0000501c

hyperfunction of drug metabolizing enzyme gene expression [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001180
Super-classes obo:TXPO_0002332c
obo:TXPO_0000889c
Restrictions obo:BFO_0000051op some obo:TXPO_0001181c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001182c

hyperfunction of cytochrome P450 gene expression [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001181
Super-classes obo:TXPO_0000889c
obo:TXPO_0002051c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001183c

hyperfunction of drug metabolism phase I by Cytochrome P450 [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001182
Super-classes obo:TXPO_0000889c
obo:TXPO_0001623c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001178c
obo:BFO_0000066op some obo:GO_0005790c
obo:BFO_0000051op some obo:TXPO_0001183c
obo:BFO_0000051op some obo:TXPO_0001178c
obo:TXPO_0000069op some obo:TXPO_0003173c
obo:TXPO_0001502op some obo:TXPO_0000117c

cytochrome P450 activation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001183
Super-classes obo:TXPO_0001758c
obo:TXPO_0000889c
Restrictions obo:RO_0000057op some obo:TXPO_0003805c
obo:RO_0000057op some obo:TXPO_0001918c
obo:TXPO_0000069op some obo:TXPO_0001184c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0003171c
obo:RO_0000057op some obo:TXPO_0003389c
obo:RO_0000057op some obo:TXPO_0003170c

NAPQI production [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001184
Super-classes obo:TXPO_0000889c
obo:TXPO_0000528c
Restrictions obo:TXPO_0001868op some obo:TXPO_0003170c
obo:RO_0002233op some obo:TXPO_0001922c
obo:TXPO_0001868op some obo:TXPO_0003805c
obo:TXPO_0001868op some obo:TXPO_0003171c
obo:RO_0002234op some obo:TXPO_0000974c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001920c

increasing demand for glutathione conjugation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001185
Super-classes obo:TXPO_0000848c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001191c
obo:TXPO_0000774op only obo:TXPO_0000501c

increasing demand for response to mitochondrial oxidative stres [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001186
Super-classes obo:TXPO_0002301c
obo:TXPO_0001730c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000042c
obo:TXPO_0000774op only obo:TXPO_0000677c

JNK translocation from cytoplasm to mitochondria [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001187
Super-classes obo:TXPO_0000889c
obo:TXPO_0001195c
Restrictions obo:RO_0000057op some obo:TXPO_0002298c
obo:TXPO_0000069op some obo:TXPO_0001207c
obo:TXPO_0000774op only obo:TXPO_0000501c

negative regulation glutathione conjugation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001188
Super-classes obo:TXPO_0002056c
obo:TXPO_0000889c
Restrictions obo:RO_0000057op some obo:TXPO_0001941c
obo:RO_0000057op some obo:TXPO_0002065c
obo:RO_0000057op some obo:TXPO_0001924c
obo:TXPO_0000069op some obo:TXPO_0001191c
obo:TXPO_0000774op only obo:TXPO_0000501c

hypofunction of drug metabolism phase II [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001189
Super-classes obo:TXPO_0002330c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

decreasing excretion quantity of the conjugates [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001190
Super-classes obo:TXPO_0000889c
obo:TXPO_0002305c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002759c
obo:TXPO_0000774op only obo:TXPO_0000501c

Glutathione conjugation (supply) - function demand imbalance [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001191
Super-classes obo:TXPO_0002302c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001193c

NAPQI accumulation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001192
Super-classes obo:TXPO_0001751c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0002233op some obo:TXPO_0000974c
obo:TXPO_0000069op some obo:TXPO_0001196c

glutathione depletion [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001193
Super-classes obo:TXPO_0000483c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001194c
obo:TXPO_0000069op some obo:TXPO_0003178c
obo:TXPO_0000069op some obo:TXPO_0001192c
obo:TXPO_0000774op only obo:TXPO_0000501c

glutathione biosynthetic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001194
Description

The formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other protein.
Super-classes obo:TXPO_0000889c
obo:GO_0006750c
Restrictions obo:RO_0000057op some obo:TXPO_0001928c
obo:RO_0000057op some obo:TXPO_0001943c
obo:TXPO_0000069op some obo:TXPO_0001925c
obo:RO_0000057op some obo:TXPO_0001929c
obo:TXPO_0000069op some obo:TXPO_0002368c
obo:RO_0000057op some obo:TXPO_0000193c
obo:TXPO_0000774op only obo:TXPO_0000501c

JNK translocation from cytoplasm to mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001195
Super-classes obo:TXPO_0000111c
Restrictions obo:RO_0002339op some obo:GO_0005739c
obo:RO_0002338op some obo:GO_0005737c
obo:TXPO_0000069op some obo:TXPO_0001207c
obo:TXPO_0000774op only obo:TXPO_0000501c
Sub-classes obo:TXPO_0001187c

protein binding by NAPQI [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001196
Super-classes obo:TXPO_0001693c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001197c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0001868op some obo:TXPO_0000974c

malfunctioning of mitochondrial ATP synthesis coupled electron transpor [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001197
Super-classes obo:TXPO_0000889c
obo:TXPO_0001846c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0001202c
obo:TXPO_0000774op only obo:TXPO_0000501c

DNA damage [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001198
Super-classes obo:NCIT_C16507c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002369c
obo:RO_0000057op some obo:TXPO_0001935c
obo:TXPO_0000069op some obo:TXPO_0001204c
obo:TXPO_0000774op only obo:TXPO_0000501c

increasing free radical [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001199
Super-classes obo:TXPO_0000889c
obo:TXPO_0001790c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002375c
obo:TXPO_0000069op some obo:TXPO_0001205c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001200c

lipoperoxidation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001200
Super-classes obo:TXPO_0000889c
obo:TXPO_0003514c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001201c
obo:TXPO_0000774op only obo:TXPO_0000501c

increasing demand for response to mitochondrial oxidative stress [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001201
Super-classes obo:TXPO_0002301c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0001935c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0001202c

mitochondrial dysfunction [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001202
Super-classes obo:TXPO_0000889c
obo:TXPO_0002361c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001203c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0001204c
obo:TXPO_0000774op only obo:TXPO_0000501c

hypofunction of ATP biosynthesis [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001203
Super-classes obo:TXPO_0001722c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001204c
obo:TXPO_0000774op only obo:TXPO_0000501c

cell death [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001204
Super-classes obo:GO_0008219c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003168c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0002372c

abnormality of membrane [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001205
Super-classes obo:TXPO_0001755c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001207c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001206c

calcium ion homeostasis imbalance [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001206
Super-classes obo:TXPO_0001765c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001204c
obo:TXPO_0000774op only obo:TXPO_0000501c

positive regulation of mitochondrial membrane permeability [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001207
Super-classes obo:TXPO_0000889c
obo:GO_0035794c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001202c

toxicological imbalance Mc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001208
Super-classes obo:TXPO_0001779c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL58288C17c and obo:TXPO_0001746c and ub744bL58310C17c)
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL58288C17c and obo:TXPO_0001746c and ub744bL58310C17c)

aryl hydrocarbon receptor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001209
Description

AhR activity is combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.
Super-classes obo:TXPO_0000158c
Sub-classes obo:TXPO_0000988c

constitutive androstane receptor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001210
Super-classes obo:TXPO_0000158c
Restrictions obo:RO_0002234op some (obo:TXPO_0003862c and ub744bL58349C17c)
Sub-classes obo:TXPO_0000935c

ATF4 gene expression regulation systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001211
Super-classes obo:TXPO_0000887c

forming a complex with Cypc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001212
Super-classes obo:GO_0006461c
Restrictions obo:RO_0002233op some obo:TXPO_0001558c
Sub-classes obo:TXPO_0000942c

p53 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001213
Super-classes obo:TXPO_0000124c

retinoid X receptor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001214
Super-classes obo:TXPO_0000158c
Sub-classes obo:TXPO_0000936c

hyperfunction of lipase gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001215
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0001218c

water accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001216
Super-classes obo:TXPO_0000488c
Sub-classes obo:TXPO_0003299c
obo:TXPO_0001369c

increasing number of apoptotic cells in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001217
Super-classes obo:TXPO_0000341c

hyperfunction of lipase gene expression [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001218
Super-classes obo:TXPO_0001720c
obo:TXPO_0001215c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

apoptosis inducer activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001219
Super-classes obo:TXPO_0000023c

lipid catabolic process [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001220
Super-classes obo:GO_0016042c
obo:TXPO_0001720c
Restrictions obo:BFO_0000051op some obo:TXPO_0001390c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0001157c

lipid transport from hepatocyte to extrahepatic [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001221
Super-classes obo:TXPO_0001720c
obo:TXPO_0001271c
Restrictions obo:BFO_0000051op some obo:TXPO_0001457c
obo:BFO_0000051op some obo:TXPO_0003487c
obo:TXPO_0000774op only obo:TXPO_0001155c

hydoroxy acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001222
Super-classes obo:TXPO_0001144c
Sub-classes obo:TXPO_0001239c
obo:TXPO_0001238c

positive regulation processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001223
Description

Any process that activates, maintains or increases the rate or extent of a process.
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002213op some obo:BFO_0000015c
Sub-classes obo:GO_0046889c
obo:GO_1900409c
obo:GO_0060697c
obo:GO_0010628c
obo:GO_0045862c
obo:GO_0035794c
obo:GO_0050996c
obo:GO_0071073c
obo:GO_0045787c
obo:GO_1903788c
obo:TXPO_0002732c
obo:TXPO_0004920c
obo:GO_0051781c
obo:TXPO_0004134c
obo:GO_1904592c

alcohol intakec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001224
Super-classes obo:TXPO_0002587c
Restrictions obo:RO_0002233op some obo:CHEBI_30879c
Sub-classes obo:TXPO_0004923c
obo:TXPO_0004255c

toxicity prediction related rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001225
Description

A role played by the entity within a toxicity prediction context.
Super-classes obo:BFO_0000023c
Sub-classes obo:TXPO_0001978c
obo:TXPO_0000080c

Acaa1a (rat)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001226
Super-classes obo:TXPO_0001088c
obo:TXPO_1000017c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

hyperfunction of glucuronic acid conjugationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001227
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0052697c
Sub-classes obo:TXPO_0001663c
obo:TXPO_0003848c
obo:TXPO_0003872c

hyperfunction of glutathione conjugationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001228
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:TXPO_0003991c
Sub-classes obo:TXPO_0001925c

increasing hepatic vascular lumen areac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001229
Super-classes obo:TXPO_0000140c
Sub-classes obo:TXPO_0000971c

smooth endoplasmic reticulum proliferation in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001230
Super-classes obo:TXPO_0000091c
Restrictions obo:RO_0002234op some (obo:GO_0005790c and ub744bL58547C17c)
Sub-classes obo:TXPO_0003903c
obo:TXPO_0000963c
obo:TXPO_0003901c
obo:TXPO_0003305c
obo:TXPO_0001677c

tumor cell invasionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001231
Super-classes obo:TXPO_0002587c
Restrictions obo:RO_0002233op some (obo:CL_0000000c and ub744bL58566C17c)
Sub-classes obo:TXPO_0004404c

sequestering of triglyceride (severe) [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001232
Super-classes obo:TXPO_0001522c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

glucose homeostasis imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001233
Super-classes obo:TXPO_0001656c
Sub-classes obo:TXPO_0004937c
obo:TXPO_0000977c

phenobarbital accumulation in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001234
Super-classes obo:TXPO_0001694c
Sub-classes obo:TXPO_0000934c

carbohydrate storage in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001235
Super-classes obo:TXPO_0000169c
Restrictions obo:RO_0002233op some obo:CHEBI_16646c
obo:BFO_0000066op only obo:CL_0000182c
Sub-classes obo:TXPO_0001266c

hyperfunction of drug metabolism phase IIc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001236
Super-classes obo:TXPO_0002347c
Sub-classes obo:TXPO_0004117c
obo:TXPO_0000943c

hyperfunction of iron supplyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001237
Super-classes obo:TXPO_0000435c
Sub-classes obo:TXPO_0000939c

citric acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001238
Super-classes obo:TXPO_0001222c

lactic acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001239
Super-classes obo:TXPO_0001222c

CAD accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001240
Super-classes obo:TXPO_0001242c
Sub-classes obo:TXPO_0003367c

CAD accumulation in lysosome [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001241
Super-classes obo:TXPO_0003367c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001403c
obo:TXPO_0000774op only obo:TXPO_0003359c

compound accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001242
Super-classes obo:TXPO_0000169c
Restrictions obo:BFO_0000066op only obo:GO_0005764c
Sub-classes obo:TXPO_0000930c
obo:TXPO_0001240c

phospholipid homeostasis imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001243
Description

phospholipid homeostasis imbalance
Super-classes obo:TXPO_0003488c
Restrictions obo:BFO_0000051op some obo:TXPO_0002308c
obo:TXPO_0001733op only obo:TXPO_0003992c
Sub-classes obo:TXPO_0000907c

phospholipid accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001244
Super-classes obo:GO_0019915c
Restrictions obo:RO_0002233op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0000281c

increasing blood glucose level [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001245
Super-classes obo:TXPO_0001912c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

hyperfunction of reduction of NAD(+) to NADH [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001246
Super-classes obo:TXPO_0001720c
obo:TXPO_0001302c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0001118c

increasing lysosomal pHc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001247
Super-classes obo:TXPO_0001520c
Sub-classes obo:TXPO_0002086c
obo:TXPO_0000912c

increasing demand for phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001248
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0000909c

undigested membrane material accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001249
Super-classes obo:TXPO_0000247c
Sub-classes obo:TXPO_0000917c

increasing phospholipidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001250
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003386c
obo:TXPO_0000923c

increasing phospholipid inflowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001251
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0000903c
obo:TXPO_0003584c

Elovl6 (mouse)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001252
Super-classes obo:TXPO_0001105c
obo:TXPO_1000125c

hypofunction of phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001253
Super-classes obo:TXPO_0002006c
Restrictions obo:RO_0002233op some obo:CHEBI_16247c
obo:TXPO_0000716op some obo:GO_0009395c
Sub-classes obo:TXPO_0000925c
obo:TXPO_0001418c
obo:TXPO_0001723c
obo:TXPO_0001287c

forming a complex of drugs and biological substancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001254
Super-classes obo:GO_0065003c
Restrictions obo:RO_0002233op some (obo:BFO_0000002c and ub744bL58779C17c)
Sub-classes obo:TXPO_0000913c
obo:TXPO_0003364c

increase in alcohol inflow into hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001255
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0001259c

negative regulation of phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001256
Super-classes obo:TXPO_0000115c
Restrictions obo:RO_0002212op some obo:GO_0009395c
Sub-classes obo:TXPO_0000827c
obo:TXPO_0003413c
obo:TXPO_0001304c
obo:TXPO_0000905c
obo:TXPO_0003446c
obo:TXPO_0000556c
obo:TXPO_0001678c

hyperfunction of dead cell phagocytosis by Kupffer cells (macrophages) [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001257
Super-classes obo:TXPO_0001716c
obo:TXPO_0000884c
Restrictions obo:RO_0000057op some obo:CL_0000235c
obo:TXPO_0000069op some obo:TXPO_0000558c
obo:RO_0000057op some obo:CL_0000091c
obo:TXPO_0000716op some obo:TXPO_0003395c
obo:TXPO_0000774op only obo:TXPO_0003452c

negative regulation of lysophagyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001258
Super-classes obo:GO_0010507c
obo:TXPO_0000755c
Restrictions obo:RO_0002213op some obo:GO_0062093c
Sub-classes obo:TXPO_0001294c

increasing uptake amount of mitochondrial calcium [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001259
Super-classes obo:TXPO_0001255c
obo:TXPO_0001720c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0001150c
obo:RO_0000057op some obo:TXPO_0000670c

forming a complex of CAD and phospholipid [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001260
Super-classes obo:TXPO_0003566c
Restrictions obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000069op some obo:TXPO_0003366c
obo:TXPO_0000774op only obo:TXPO_0002215c

hypofunction of phospholipid export from lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001261
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:TXPO_0003388c
obo:BFO_0000066op some obo:GO_0005764c
Sub-classes obo:TXPO_0003366c
obo:TXPO_0001262c

hypofunction of phospholipid export from lysosome [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001262
Super-classes obo:TXPO_0001716c
obo:TXPO_0001261c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003435c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000716op some obo:TXPO_0000200c

changing balance of phospholipid metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001263
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0000946c

hyperfunction of glycerophospholipid synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001264
Super-classes obo:TXPO_0001726c
Sub-classes obo:TXPO_0001662c
obo:TXPO_0001612c
obo:TXPO_0001587c
obo:TXPO_0001646c
obo:TXPO_0001655c
obo:TXPO_0001596c

lipid storage in liver [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001265
Super-classes obo:TXPO_0001276c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c

carbohydrate storage in liver [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001266
Super-classes obo:TXPO_0001235c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c
obo:TXPO_0000069op some obo:TXPO_0003297c

moving lipid to the hepatocyte [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001267
Super-classes obo:TXPO_0001720c
obo:TXPO_0001270c
Restrictions obo:BFO_0000051op some obo:TXPO_0001049c
obo:TXPO_0000774op only obo:TXPO_0001155c

malfunctioning of TCA cycle [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001268
Super-classes obo:TXPO_0003742c
obo:TXPO_0001269c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001305c
obo:TXPO_0000774op only obo:TXPO_0002329c
obo:BFO_0000066op some obo:GO_0005739c

malfunctioning of TCA cyclec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001269
Super-classes obo:TXPO_0002130c
Restrictions obo:TXPO_0000716op some obo:GO_0006099c
Sub-classes obo:TXPO_0001130c
obo:TXPO_0001268c
obo:TXPO_0004126c

moving lipid to the hepatocyec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001270
Super-classes obo:TXPO_0002587c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
obo:RO_0002233op some obo:CHEBI_18059c
Sub-classes obo:TXPO_0001466c
obo:TXPO_0001267c
obo:TXPO_0002021c

lipid efflux from hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001271
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:CHEBI_18059c
Sub-classes obo:TXPO_0001221c

hyperfunction of alcohol metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001272
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0006066c
Sub-classes obo:TXPO_0001150c
obo:TXPO_0000503c

increaseing production quantity of catecholamine [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001273
Super-classes obo:TXPO_0001720c
obo:TXPO_0001421c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000892c
obo:TXPO_0000774op only obo:TXPO_0001155c

ethanolamine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001274
Description

related molecular function GO:0004305 ethanolamine kinase activity
Super-classes obo:TXPO_0001515c

EIF2A (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001275
Super-classes obo:TXPO_1000421c
obo:TXPO_0000871c
Sub-classes obo:TXPO_0000829c
obo:TXPO_0003588c
obo:TXPO_0002932c

lipid storage in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001276
Super-classes obo:GO_0019915c
Restrictions obo:RO_0002233op some obo:CHEBI_18059c
obo:BFO_0000066op only obo:UBERON_0002107c
Sub-classes obo:TXPO_0002172c
obo:TXPO_0000897c
obo:TXPO_0001265c
obo:TXPO_0004759c
obo:TXPO_0002004c
obo:TXPO_0003210c

cholestasis [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001277
Description

This entity is under construction.

Drug induced liver injury (DILI) is categorized as drug induced cholestasis (DIC), drug-induced hepatitis, and is mixed liver injury. Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS). phallodin, microsystin, amantin is facilitated by the uptake thpugh OATPs. rifampicin, bosentan, troglitazone directly inhibit BSEP.
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0000350c
obo:TXPO_0000004op some obo:TXPO_0000350c
Sub-classes obo:TXPO_0002651c
obo:TXPO_0002650c

canalicular cholestasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001278
Description

under construction
Super-classes obo:TXPO_0002650c

intrahepatic billiary stasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001279
Description

under construction
Super-classes obo:TXPO_0002650c

eosinogranular degeneration dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001280
Super-classes obo:TXPO_0000835c
Sub-classes obo:TXPO_0002062c
obo:TXPO_0001328c
obo:TXPO_0001050c

VLDL formation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001281
Super-classes obo:GO_0034379c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0000057op some obo:TXPO_0001405c
obo:TXPO_0000069op some obo:TXPO_0001371c
obo:RO_0002234op some obo:TXPO_0001351c

CASPASE-2 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001282
Super-classes obo:TXPO_0000502c

NRF2 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001283
Super-classes obo:TXPO_0000124c
Restrictions obo:RO_0002234op some (obo:TXPO_0002527c and ub744bL59157C17c)
Sub-classes obo:TXPO_0002216c
obo:TXPO_0001370c

CD36 activation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001284
Super-classes obo:TXPO_0001720c
obo:TXPO_0001309c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0002234op some obo:TXPO_0001319c
obo:TXPO_0000069op some obo:TXPO_0001500c

liver dysfunction [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001285
Super-classes obo:TXPO_0001716c
obo:TXPO_0000203c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000066op some obo:UBERON_0002107c

obesityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001286
Super-classes obo:TXPO_0000040c
Sub-classes obo:TXPO_0002241c

hypofunction of phosphosphingolipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001287
Super-classes obo:TXPO_0001253c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001465c
obo:RO_0002233op some obo:CHEBI_35786c
Sub-classes obo:TXPO_0001676c

hyperfunction of reduction of NAD(+) to NADH [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001288
Super-classes obo:TXPO_0003742c
obo:TXPO_0001302c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001289c
obo:TXPO_0000774op only obo:TXPO_0002329c

increasing NAD/NAD+ ratio [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001289
Super-classes obo:TXPO_0003742c
obo:TXPO_0001292c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0001268c

hyperfunction of sphingophospholipid synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001290
Super-classes obo:TXPO_0001726c
Sub-classes obo:TXPO_0001674c

phosphosphingolipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001291
Super-classes obo:GO_0008654c
Restrictions obo:RO_0002234op some obo:CHEBI_35786c
Sub-classes obo:GO_0006686c

increasing NAD/NAD+ ratioc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001292
Super-classes obo:TXPO_0000352c
Sub-classes obo:TXPO_0001118c
obo:TXPO_0001289c

sphingophopholipid metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001293
Super-classes obo:TXPO_0002308c
Sub-classes obo:TXPO_0001672c

negative regulation of lysophagy [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001294
Super-classes obo:TXPO_0001716c
obo:TXPO_0001258c
Restrictions obo:RO_0002212op some obo:GO_0062093c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0004113c

glycerophospholipid metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001295
Super-classes obo:TXPO_0002308c
Sub-classes obo:TXPO_0001608c
obo:TXPO_0001585c
obo:TXPO_0001594c
obo:TXPO_0001642c
obo:TXPO_0001640c
obo:TXPO_0001644c

increasing number of damaged lysosomesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001296
Super-classes obo:TXPO_0000093c
Restrictions obo:RO_0002234op some (obo:GO_0005764c and ub744bL59319C17c)
obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:TXPO_0001400c

hypofunction of maintaining lysosome homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001297
Super-classes obo:TXPO_0000436c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
Sub-classes obo:TXPO_0001752c

autophagy [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001298
Super-classes obo:GO_0006914c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

network attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001299
Super-classes obo:TXPO_0000305c
Sub-classes obo:TXPO_0000554c
obo:TXPO_0000553c

refolding promoting gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001300
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0002716c

SCD (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001301
Super-classes obo:TXPO_0000587c
obo:TXPO_0003516c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006319c
obo:RO_0000087op some obo:TXPO_0003329c

hyperfunction of reduction of NAD(+) to NADHc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001302
Super-classes obo:TXPO_0002058c
Restrictions obo:TXPO_0001502op some obo:GO_0006735c
Sub-classes obo:TXPO_0001288c
obo:TXPO_0001246c

PLBc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001303
Super-classes obo:TXPO_0000635c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:TXPO_1000284c

negative regulation of glycerophospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001304
Super-classes obo:TXPO_0001256c
Restrictions obo:RO_0002212op some obo:GO_0046475c
Sub-classes obo:TXPO_0001666c
obo:TXPO_0001614c
obo:TXPO_0001650c
obo:TXPO_0001659c
obo:GO_0010900c
obo:TXPO_0001598c

acetyl CoA increase [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001305
Super-classes obo:TXPO_0003742c
obo:TXPO_0000088c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001310c
obo:TXPO_0000774op only obo:TXPO_0002329c

ATF6 (ATF6-alpha) activates chaperone genes [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001306
Super-classes obo:TXPO_0000583c
obo:TXPO_0003736c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002899c
obo:TXPO_0000774op only obo:TXPO_0000413c

choline transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001307
Description

related molecular function GO:0015220
Super-classes obo:TXPO_0003698c

Lgpat1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001308
Super-classes obo:TXPO_0000740c
Sub-classes obo:TXPO_0001176c

CD 36 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001309
Super-classes obo:TXPO_0000023c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000899c
obo:RO_0002234op some (obo:TXPO_0001312c and ub744bL59458C17c)
Sub-classes obo:TXPO_0001284c

hypofunction of fatty acid beta-oxidation [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001310
Super-classes obo:TXPO_0002008c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0001387c

negative regulation of insulin secretion [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001311
Super-classes obo:GO_0046676c
obo:TXPO_0001717c
Restrictions obo:RO_0000057op some obo:TXPO_0000805c
obo:TXPO_0000774op only obo:TXPO_0002528c

CD36 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001312
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084320c
Sub-classes obo:TXPO_0001319c

AP-1 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001313
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0001321c

increasing phospholipid materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001314
Super-classes obo:TXPO_0001075c
Sub-classes obo:TXPO_0001317c
obo:TXPO_0001762c
obo:TXPO_0001669c
obo:TXPO_0003403c

increasing phospholipid material [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001315
Super-classes obo:TXPO_0001762c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002223c
obo:RO_0000057op some obo:TXPO_0001136c
obo:TXPO_0000774op only obo:TXPO_0002215c

role related to molecular changec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001316
Super-classes obo:TXPO_0003712c
Sub-classes obo:CHEBI_22333c
obo:TXPO_0002246c

increasing glycerophospholipid materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001317
Super-classes obo:TXPO_0001314c
Sub-classes obo:TXPO_0001592c
obo:TXPO_0001318c
obo:TXPO_0001794c
obo:TXPO_0001583c
obo:TXPO_0001630c
obo:TXPO_0001606c
obo:TXPO_0001653c
obo:TXPO_0001628c

increasing glycerophospholipid material [phospholipidosis - glycerophospholipid disorder (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001318
Super-classes obo:TXPO_0001317c
Restrictions obo:RO_0000057op some obo:TXPO_0001136c
obo:BFO_0000051op some obo:TXPO_0001320c

CD36 [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001319
Super-classes obo:TXPO_0001312c
Restrictions obo:RO_0000087op some obo:TXPO_0001341c
Sub-classes obo:TXPO_0001498c

choline transport [Phospholipidosis - phosphatidylcholine disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001320
Super-classes obo:TXPO_0001716c
obo:GO_0015871c
Restrictions obo:RO_0000057op some obo:TXPO_0001136c
obo:TXPO_0000069op some obo:GO_0006656c

AP-1 activation by JNKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001321
Super-classes obo:TXPO_0001313c
Sub-classes obo:TXPO_0002829c
obo:TXPO_0001322c

AP-1 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001322
Super-classes obo:TXPO_0001321c

hypofunction of hepatic metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001323
Super-classes obo:TXPO_0002354c
Restrictions obo:TXPO_0000716op some obo:GO_0008152c
obo:BFO_0000066op only obo:UBERON_0002107c

hypofunction of protein metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001324
Super-classes obo:TXPO_0002354c
Restrictions obo:TXPO_0000716op some obo:GO_0019538c
obo:BFO_0000051op some obo:TXPO_0001331c

hypofunction of lipid metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001325
Super-classes obo:TXPO_0002354c
Restrictions obo:BFO_0000051op some obo:TXPO_0001327c
obo:TXPO_0000716op some obo:GO_0006629c

hypofunction of carbohydrate metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001326
Super-classes obo:TXPO_0002354c
Restrictions obo:TXPO_0000716op some obo:GO_0005975c
Sub-classes obo:TXPO_0002188c

hypofunction of cholesterol biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001327
Super-classes obo:TXPO_0002195c
Restrictions obo:TXPO_0000716op some obo:GO_0006695c
obo:TXPO_0000069op some obo:TXPO_0001330c

PPARA (canonical)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001328
Super-classes obo:TXPO_0000159c
obo:TXPO_0001280c
Sub-classes obo:TXPO_0003409c
obo:TXPO_0004006c

Hmox1 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001329
Super-classes obo:TXPO_1000196c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

decreasing cholesterol concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001330
Super-classes obo:TXPO_0000671c

hypofunction of albumin biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001331
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001332c

decreasing albumin concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001332
Super-classes obo:TXPO_0000671c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001333c

decreasing blood osmotic pressure.c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001333
Super-classes obo:TXPO_0003307c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001380c

movement attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001334
Super-classes obo:TXPO_0000305c
Sub-classes obo:TXPO_0001525c

decreasing amount of circulating bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001335
Super-classes obo:TXPO_0000359c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001336c

decreasing renal blood flowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001336
Super-classes obo:TXPO_0000359c

increasing creatinine concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001337
Super-classes obo:TXPO_0000352c

renin-angiotensin activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001338
Super-classes obo:TXPO_0000401c

low-density lipoproteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001339
Super-classes obo:CHEBI_6495c

hypofunction of retinol storagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001340
Super-classes obo:TXPO_0000436c

fatty acid transporter rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001341
Super-classes obo:TXPO_0003699c
Sub-classes obo:TXPO_0001499c

hypofunction of liver's excretionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001342
Super-classes obo:TXPO_0002355c
Sub-classes obo:TXPO_0001348c
obo:TXPO_0002304c

bile acid biosynthetic malfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001343
Super-classes obo:TXPO_0002073c

bile secretion malfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001344
Super-classes obo:TXPO_0002073c
Restrictions obo:BFO_0000051op some obo:TXPO_0001347c
obo:BFO_0000051op some obo:TXPO_0001346c
obo:BFO_0000051op some obo:TXPO_0001345c

cholestasis (primitive process)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001345
Super-classes obo:TXPO_0001581c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001346c
obo:TXPO_0000069op some obo:TXPO_0001347c
obo:TXPO_0000069op some obo:TXPO_0001348c
Sub-classes obo:TXPO_0000350c
obo:TXPO_0002734c

inreasing blood ALP concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001346
Super-classes obo:TXPO_0000352c
Sub-classes obo:TXPO_0000041c

increasing γ-glutamyltransferase concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001347
Super-classes obo:TXPO_0000352c
Restrictions obo:RO_0002234op some (obo:TXPO_0000856c and ub744bL59844C17c)
Sub-classes obo:TXPO_0000859c

hypofunction of bilirubin excretionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001348
Super-classes obo:TXPO_0001342c

increasing bilirubin concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001349
Super-classes obo:TXPO_0000352c

jaundice (Process)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001350
Super-classes obo:TXPO_0001616c

VLDL (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001351
Super-classes obo:TXPO_0003516c
obo:CHEBI_39027c
Restrictions obo:RO_0000087op some obo:TXPO_0003699c

hypofunction of blood coagulation factor synthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001352
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001353c

bleedingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001353
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:UBERON_0000178c

hypofunction of detoxificationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001354
Super-classes obo:TXPO_0000436c
Sub-classes obo:TXPO_0000016c

increasing ammonia concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001355
Super-classes obo:TXPO_0000352c
Sub-classes obo:TXPO_0000017c

VLDL release from hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001356
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:CHEBI_39027c
obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0001371c

hepatic vascular circulation disorder (toxic course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001357
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0003459c
obo:BFO_0000051op some obo:TXPO_0003466c
obo:BFO_0000051op some obo:TXPO_0003457c
obo:BFO_0000051op some obo:TXPO_0003617c
obo:TXPO_0000004op some obo:TXPO_0003617c
obo:BFO_0000051op some obo:TXPO_0003458c
obo:BFO_0000051op some obo:TXPO_0003461c
obo:BFO_0000051op some obo:TXPO_0003460c
obo:BFO_0000051op some obo:TXPO_0003619c

hepatic shunt formtionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001358
Description

It makes abnormal communications between the hepatic arteries, portal veins, and hepatic or systemic veins.
Super-classes obo:TXPO_0000134c
Sub-classes obo:TXPO_0003619c

increasing hepatic portal pressurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001359
Super-classes obo:TXPO_0001689c
Sub-classes obo:TXPO_0003457c

inzreasing size of the spleenc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001360
Super-classes obo:TXPO_0000138c
Sub-classes obo:TXPO_0003462c

spleen hyperfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001361
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001362c
obo:TXPO_0000069op some obo:TXPO_0001479c
Sub-classes obo:TXPO_0003616c

decreasing hemoglobin concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001362
Super-classes obo:TXPO_0000671c

bypass formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001363
Super-classes obo:TXPO_0000134c
Sub-classes obo:TXPO_0003466c

varicosity of veins formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001364
Super-classes obo:TXPO_0000134c
Sub-classes obo:TXPO_0003467c

stomach congestionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001365
Super-classes obo:TXPO_0000916c
Restrictions obo:BFO_0000066op some obo:UBERON_0000945c
Sub-classes obo:TXPO_0003463c

increasing hepatic venous pressurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001366
Super-classes obo:TXPO_0001689c
Sub-classes obo:TXPO_0003458c

hyperfunction of hepatic lymph productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001367
Super-classes obo:TXPO_0002346c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001368c
Sub-classes obo:TXPO_0003459c

hepatic lymph leakagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001368
Super-classes obo:TXPO_0001699c
Sub-classes obo:TXPO_0003460c

ascites (process)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001369
Super-classes obo:TXPO_0001216c
Sub-classes obo:TXPO_0003461c

NRF2 activation by PERKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001370
Super-classes obo:TXPO_0001283c
Sub-classes obo:TXPO_0000403c
obo:TXPO_0002736c

VLDL release from hepatocyte [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001371
Super-classes obo:TXPO_0001720c
obo:TXPO_0001356c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c

increasing aldosterone concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001372
Super-classes obo:TXPO_0000352c

nephrotoxic agentc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001373
Super-classes obo:TXPO_0000038c

edema (process)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001374
Super-classes obo:TXPO_0000488c
Restrictions obo:TXPO_0000531op some obo:HP_0000969c

hypofunction of hormone metabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001375
Super-classes obo:TXPO_0002354c
Sub-classes obo:TXPO_0005061c

hypofunction of estrogen degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001376
Super-classes obo:TXPO_0000940c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001377c

increasing estrogen concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001377
Super-classes obo:TXPO_0000352c

hyperfunction of glutathione synthetic gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001378
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0001933c

lipid degradation related gene expression [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001379
Super-classes obo:TXPO_0001720c
obo:TXPO_0001381c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:BFO_0000066op some obo:GO_0005634c
obo:TXPO_0000069op some obo:TXPO_0001220c

leaking fluid from blood vesselc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001380
Super-classes obo:TXPO_0001699c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001374c

lipid degradation related gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001381
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0001379c

growth factor familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001382
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0000032c
obo:IMR_0000033c
obo:IMR_0000047c
obo:IMR_0000034c
obo:IMR_0000045c
obo:IMR_0000036c
obo:IMR_0000049c
obo:IMR_0000031c

lipid synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001383
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0001386c

MMP inactivation by TIMP1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001384
Super-classes obo:TXPO_0000021c
Sub-classes obo:TXPO_0001721c

acyltransferasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001385
Super-classes obo:TXPO_0000606c
Sub-classes obo:TXPO_0001967c
obo:IMR_0010252c
obo:TXPO_0000858c
obo:TXPO_0001397c

lipid synthesis gene expression [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001386
Super-classes obo:TXPO_0001720c
obo:TXPO_0001383c
Restrictions obo:BFO_0000066op some obo:GO_0005634c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0001868op some obo:TXPO_0003812c
obo:RO_0002234op some obo:TXPO_0001301c
obo:RO_0002234op some obo:TXPO_0001401c
obo:RO_0002234op some obo:TXPO_0001394c
obo:TXPO_0000069op some obo:TXPO_0001141c

fatty acid strorage [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001387
Super-classes obo:TXPO_0003742c
obo:TXPO_0000256c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c

mitochondrial fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001388
Super-classes obo:GO_0006635c
Sub-classes obo:TXPO_0001390c
obo:TXPO_0004360c

negative regulation of lipid transport from liver to peripheral tissue [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001389
Super-classes obo:TXPO_0001407c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001265c
obo:TXPO_0000774op only obo:TXPO_0002329c

mitochondrial fatty acid beta-oxidation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001390
Super-classes obo:TXPO_0001720c
obo:TXPO_0001388c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

negative regulation of lipid transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001391
Super-classes obo:TXPO_0002682c
Sub-classes obo:TXPO_0001407c

Bcl2 phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001392
Super-classes obo:GO_0016310c
Sub-classes obo:TXPO_0002952c

transmitter rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001393
Super-classes obo:TXPO_0003727c
Sub-classes obo:TXPO_0003814c
obo:TXPO_0004097c
obo:TXPO_0003723c
obo:TXPO_0003638c
obo:CHEBI_33280c

FATTY Acid Synthase (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001394
Super-classes obo:TXPO_0003516c
obo:TXPO_0001424c
Restrictions obo:RO_0000087op some obo:IMR_0010252c

ASAH1 (human)[Phospholipidosis - tumor cell proliferation induction]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001395
Super-classes obo:TXPO_0000529c
Restrictions obo:TXPO_0000756op some obo:TXPO_0001442c
obo:RO_0000087op some obo:TXPO_0002397c

microscopy assayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001396
Super-classes obo:OBI_0000185c
Sub-classes obo:OBI_0001631c

histone acetyltransferasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001397
Description

related molecular function GO:0004402
Super-classes obo:TXPO_0001385c

CAD insertion into phospholipase binding site to lysosomal inner membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001398
Description

Under normal conditions, lysosomal phospholipase A2 is bound through electrostatic charge interactions to the inner membranes of the lysosome. A cationic amphiphile, accumulates in the lysosome and inserts into the inner membrane decreasing or eliminating the anionic binding sites for the lipase. The lipase is no longer able to bind to its substrates and is potentially susceptible to degradation by lysosomal proteases.
Super-classes obo:GO_0005488c
Sub-classes obo:TXPO_0001399c

CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001399
Super-classes obo:TXPO_0001716c
obo:TXPO_0001398c
Restrictions obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0003449c
obo:TXPO_0002572c
obo:TXPO_0003368c
obo:TXPO_0003362c

increasing number of damaged lysosomes[Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001400
Super-classes obo:TXPO_0001716c
obo:TXPO_0001296c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:BFO_0000066op some obo:CL_0000000c
obo:RO_0002234op some (obo:GO_0005764c and ub744bL60373C17c)
obo:TXPO_0000069op some obo:TXPO_0001294c

ACC1 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001401
Super-classes obo:TXPO_0003970c
obo:TXPO_0003516c
Restrictions obo:RO_0000087op some obo:TXPO_0003973c

negative regulation of phospholipid bindingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001402
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0005543c
Sub-classes obo:TXPO_0001404c

negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001403
Super-classes obo:TXPO_0003414c
Restrictions obo:TXPO_0000012op some obo:TXPO_0003412c
obo:TXPO_0000774op only obo:TXPO_0003359c
obo:TXPO_0001868op some obo:TXPO_0003227c
obo:TXPO_0001868op some obo:TXPO_0000319c
obo:TXPO_0000069op some obo:TXPO_0002087c
obo:TXPO_0001868op some obo:TXPO_0003228c
obo:TXPO_0000012op some obo:TXPO_0003362c

negative regulation of phospholipase binding to phospholipid by CADc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001404
Super-classes obo:TXPO_0001402c

Dgat1 (rat)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001405
Super-classes obo:TXPO_0001088c
obo:TXPO_0001423c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000756op some obo:TXPO_0000489c

phospholipid catabolic process [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001406
Super-classes obo:GO_0009395c
obo:TXPO_0001716c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000012op some obo:TXPO_0003404c
obo:TXPO_0000012op some obo:TXPO_0003410c
obo:TXPO_0000069op some obo:TXPO_0001435c

negative regulation of lipid transport from liver to peripheral tissuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001407
Super-classes obo:TXPO_0001391c
Sub-classes obo:TXPO_0001389c

increasing production amount of acetaldehyde [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001408
Super-classes obo:TXPO_0001409c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003779c
obo:TXPO_0000774op only obo:TXPO_0002329c

increasing production amount of acetaldehydec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001409
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0001408c
obo:TXPO_0001132c

hyperfunction of phospholipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001410
Super-classes obo:TXPO_0002346c
Restrictions obo:TXPO_0001502op some obo:GO_0008654c
Sub-classes obo:TXPO_0001624c
obo:TXPO_0000908c
obo:TXPO_0001411c

hyperfunction of glycerophospholipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001411
Super-classes obo:TXPO_0001410c
Restrictions obo:TXPO_0001502op some obo:GO_0046474c
Sub-classes obo:TXPO_0001603c
obo:TXPO_0001622c
obo:TXPO_0001604c
obo:TXPO_0001602c
obo:TXPO_0001601c
obo:TXPO_0001600c

increasing number of macrophage derived foam cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001412
Super-classes obo:TXPO_0000093c
Restrictions obo:RO_0002234op some (obo:CL_0000891c and ub744bL60550C17c)
Sub-classes obo:TXPO_0000918c

hypofunction of ceramide biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001413
Super-classes obo:TXPO_0002195c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001330c
obo:TXPO_0000716op some obo:GO_0046513c

eIF2a translation regulation systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001414
Super-classes obo:TXPO_0000887c

hyperfunction of choline transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001415
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:GO_0015871c
Sub-classes obo:TXPO_0001416c

hyperfunction of choline transport [Phospholipidosis - phosphatidylcholine disorder (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001416
Super-classes obo:TXPO_0001415c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0001136c

DGAT(mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001417
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084649c
Sub-classes obo:TXPO_0001423c
obo:TXPO_1000113c

hypofunction of glycerophospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001418
Super-classes obo:TXPO_0001253c
Restrictions obo:RO_0002233op some obo:CHEBI_37739c
obo:TXPO_0000716op some obo:GO_0046475c
Sub-classes obo:TXPO_0001545c
obo:TXPO_0001420c
obo:TXPO_0001664c
obo:TXPO_0001657c
obo:TXPO_0001648c
obo:TXPO_0001610c

increaseing production quantity of catecholamine [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001419
Super-classes obo:TXPO_0003742c
obo:TXPO_0001421c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001467c
obo:TXPO_0000774op only obo:TXPO_0002329c

hypofunction of phosphatidylcholine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001420
Super-classes obo:TXPO_0001418c
Restrictions obo:TXPO_0000716op some obo:GO_0034638c
obo:RO_0002233op some obo:CHEBI_64482c

increaseing production quantity of catecholaminec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001421
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0001273c
obo:TXPO_0001419c

heoatocyte growth [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001422
Super-classes obo:TXPO_0001578c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c
obo:TXPO_0000069op some obo:TXPO_0000217c

DGAT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001423
Super-classes obo:TXPO_0001417c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084649c
Sub-classes obo:TXPO_0001405c

FASNc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001424
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001394c

gentamicin_phospholipase inhibitor [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001425
Super-classes obo:CHEBI_17833c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0000562c

Cationic Amphiphilic Drug rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001426
Description

CADs exhibit the property of lysosomotropism, the property of a molecule to specifically associate with lysosomes.

In theory, CADs could enter the lysosome through endocytosis, autophagy, or a drug-specific transporter. However, passive diffusion has been invoked as the major mechanism whereby CADs accumulate within the lysosome . CADs bind directly to phospholipids to result in indigestible drug–lipid complexes, which accumulate and are stored in the form of lysosomal lamellar bodies. Production of lamellar bodies was associated with inhibition of phospholipase activity; either due to direct inhibition or interaction of CAD at the phospholipid bilayer of the lysosome.
Super-classes obo:CHEBI_52210c

cell proliferation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001427
Super-classes obo:TXPO_0001716c
obo:GO_0008283c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

ABCA1 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001428
Super-classes obo:TXPO_0001443c
obo:TXPO_0003516c
Restrictions obo:RO_0000087op some obo:TXPO_0001451c

CHOP gene expression regulation systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001429
Super-classes obo:TXPO_0000887c

hyperfunction of phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001430
Super-classes obo:TXPO_0002349c
Restrictions obo:TXPO_0001502op some obo:GO_0006644c
Sub-classes obo:TXPO_0003583c

hyperfunction of phospholipid degradation [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001431
Super-classes obo:TXPO_0003583c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c

ground glass apperance [toxic corse]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001432
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0001665c
obo:BFO_0000051op some obo:TXPO_0002068c
obo:BFO_0000051op some obo:TXPO_0000443c
obo:BFO_0000051op some obo:TXPO_0003859c
obo:BFO_0000051op some obo:TXPO_0001827c
obo:TXPO_0000004op some obo:TXPO_0000963c
obo:BFO_0000051op some obo:TXPO_0000963c
obo:BFO_0000051op some obo:TXPO_0002600c
Sub-classes obo:TXPO_0001679c
obo:TXPO_0003857c

dysfunction of protein refoldingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001433
Super-classes obo:TXPO_0000438c

phospholipid metabolism balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001434
Super-classes obo:TXPO_0000682c
Sub-classes obo:TXPO_0002293c
obo:TXPO_0001782c
obo:TXPO_0001435c
obo:TXPO_0001576c
obo:TXPO_0003651c

phospholipid metabolism balance [phopholipidosis - normal]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001435
Super-classes obo:TXPO_0000946c
obo:TXPO_0001434c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003356c
obo:TXPO_0001733op some obo:TXPO_0002076c
obo:TXPO_0000069op some obo:TXPO_0001683c

ATF6 gene expression regulation systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001436
Super-classes obo:TXPO_0000887c

phospholipidosis (genetic)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001437
Super-classes obo:TXPO_0002215c
Restrictions obo:BFO_0000051op some obo:TXPO_0001776c
obo:BFO_0000051op some obo:TXPO_0003985c
obo:BFO_0000051op some obo:TXPO_0002069c
obo:BFO_0000051op some obo:TXPO_0002070c
obo:TXPO_0000004op only obo:TXPO_0001776c
obo:BFO_0000051op some obo:TXPO_0001463c
Sub-classes obo:TXPO_0001685c

loss of phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001438
Super-classes obo:TXPO_0000439c
Restrictions obo:TXPO_0000716op some obo:GO_0009395c
Sub-classes obo:TXPO_0001439c

loss of phospholipid degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001439
Super-classes obo:TXPO_0001716c
obo:TXPO_0001438c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

loss of structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001440
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0001441c

genetic defectc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001441
Super-classes obo:TXPO_0001440c

in vitro (human) 24hrc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001442
Super-classes obo:TXPO_0000795c

ABCA1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001443
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001428c

phopholipase gene mutationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001444
Super-classes obo:TXPO_0001985c
Sub-classes obo:TXPO_0001445c
obo:TXPO_0001463c

sphingomyelinase gene mutationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001445
Super-classes obo:TXPO_0001444c
Sub-classes obo:TXPO_0001688c

sphingomyelinase gene mutation [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001446
Super-classes obo:TXPO_0003635c
obo:TXPO_0001688c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001475c
obo:TXPO_0000774op only obo:TXPO_0001462c
obo:TXPO_0000069op some obo:TXPO_0004141c
obo:RO_0000057op some obo:TXPO_0003469c
Sub-classes obo:TXPO_0003468c
obo:TXPO_0003473c

dysfunction of phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001447
Super-classes obo:TXPO_0001741c
Restrictions obo:RO_0002233op some obo:CHEBI_16247c
obo:TXPO_0000716op some obo:GO_0009395c
Sub-classes obo:TXPO_0002069c
obo:TXPO_0002310c
obo:TXPO_0001474c
obo:TXPO_0001448c

dysfunction of phospholipid degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001448
Super-classes obo:TXPO_0001447c
obo:TXPO_0000925c
Restrictions obo:RO_0000057op some obo:TXPO_0001804c
obo:TXPO_0000069op some obo:TXPO_0001778c
obo:RO_0000057op some obo:TXPO_0000775c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0002069c
obo:TXPO_0002098c

cell rupture [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001449
Super-classes obo:TXPO_0001651c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000527c
obo:TXPO_0000774op only obo:TXPO_0000678c

hypofunction of mitochondrial fatty acid beta-oxidation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001450
Super-classes obo:TXPO_0000889c
obo:TXPO_0002112c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:BFO_0000066op some obo:GO_0005739c

cholesterol transporter rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001451
Super-classes obo:TXPO_0003699c

Bhmt (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001452
Super-classes obo:TXPO_0001134c
obo:TXPO_1000046c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

malfunctioning of intracellular signal transductionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001453
Super-classes obo:TXPO_0000434c
Sub-classes obo:TXPO_0001125c

malfunctioning of receptor functionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001454
Super-classes obo:TXPO_0000434c
Restrictions obo:TXPO_0001518op some obo:TXPO_0000379c

positive regulation of autophagy [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001455
Super-classes obo:GO_0010508c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000204c
obo:TXPO_0000069op some obo:TXPO_0000371c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0003490c
obo:RO_0000057op some obo:TXPO_0000451c

changing membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001456
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0005000c
obo:TXPO_0001995c

cholesterol efflux from hepatoyte [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001457
Super-classes obo:TXPO_0001720c
obo:GO_0033344c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001428c
obo:TXPO_0000774op only obo:TXPO_0001155c

hypofunction of cholesterol export from hepatoyte [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001458
Super-classes obo:TXPO_0003483c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003491c
obo:TXPO_0000716op some obo:TXPO_0001457c
obo:TXPO_0000774op only obo:TXPO_0000888c

relative valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001459
Super-classes obo:TXPO_0000288c
Sub-classes obo:TXPO_0001461c
obo:TXPO_0001460c

relative large (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001460
Super-classes obo:TXPO_0001459c

relative small (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001461
Super-classes obo:TXPO_0001459c

course of Niemann–Pick disease type A and type Bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001462
Description

Niemann–Pick disease type A and type B are inherited as autosomal recessive deficiency of the enzyme sphingomyelinase, in the lysosomes of the reticuloendothelial system. This results in the lysosomal storage of sphingomyelin. The liver and spleen are predominantly involved.

Sherlock's Diseases of the Liver and Biliary System, 12th Edition
Super-classes obo:TXPO_0003587c
obo:TXPO_0001685c
Restrictions obo:BFO_0000051op some obo:TXPO_0003988c
obo:BFO_0000051op some obo:TXPO_0001807c
obo:BFO_0000051op some obo:TXPO_0001476c
obo:BFO_0000051op some obo:TXPO_0004141c
obo:TXPO_0000004op only obo:TXPO_0001476c
obo:BFO_0000051op some obo:TXPO_0002072c
obo:BFO_0000051op some obo:TXPO_0001475c
obo:BFO_0000051op some obo:TXPO_0004146c
obo:BFO_0000051op some obo:TXPO_0002071c
obo:BFO_0000051op some obo:TXPO_0001478c
obo:BFO_0000051op some obo:TXPO_0001446c
obo:BFO_0000051op some obo:TXPO_0002263c
Sub-classes obo:TXPO_0001468c
obo:TXPO_0001469c

phopholipase gene mutation [Phospholipidosis - genetic]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001463
Super-classes obo:TXPO_0001716c
obo:TXPO_0001444c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001437c
obo:TXPO_0000069op some obo:TXPO_0002069c
Sub-classes obo:TXPO_0001688c

SMPD1 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001464
Super-classes obo:TXPO_1000347c
obo:TXPO_0003213c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:TXPO_0003469c

sphingophospholipid catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001465
Super-classes obo:TXPO_0000071c
obo:GO_0009395c
Restrictions obo:RO_0002233op some obo:CHEBI_35786c
Sub-classes obo:GO_0006685c

moving fatty acid to the hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001466
Super-classes obo:TXPO_0001270c
Sub-classes obo:TXPO_0001049c
obo:TXPO_0001496c

increaing in fatty acid inflow into hepatocyte [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001467
Super-classes obo:TXPO_0003742c
obo:TXPO_0003492c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0001265c

course of Niemann–Pick disease type Ac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001468
Super-classes obo:TXPO_0001462c
Restrictions obo:TXPO_0000004op only obo:TXPO_0001482c
obo:BFO_0000051op some obo:TXPO_0001818c
obo:BFO_0000051op some obo:TXPO_0003986c
obo:BFO_0000051op some obo:TXPO_0001815c
obo:TXPO_0003585op some obo:DOID_0070111c
obo:BFO_0000051op some obo:TXPO_0001482c
obo:BFO_0000051op some obo:TXPO_0003474c
obo:BFO_0000051op some obo:TXPO_0003579c
obo:BFO_0000051op some obo:TXPO_0003468c
obo:BFO_0000051op some obo:TXPO_0001481c
obo:BFO_0000051op some obo:TXPO_0001817c
obo:BFO_0000051op some obo:TXPO_0001471c

course of Niemann–Pick disease type Bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001469
Super-classes obo:TXPO_0001462c
Restrictions obo:BFO_0000051op some obo:TXPO_0001814c
obo:BFO_0000051op some obo:TXPO_0001816c
obo:BFO_0000051op some obo:TXPO_0001480c
obo:BFO_0000051op some obo:TXPO_0003987c
obo:TXPO_0000004op only obo:TXPO_0001816c
obo:BFO_0000051op some obo:TXPO_0003580c
obo:BFO_0000051op some obo:TXPO_0003475c
obo:BFO_0000051op some obo:TXPO_0001811c
obo:BFO_0000051op some obo:TXPO_0003473c
obo:BFO_0000051op some obo:TXPO_0001809c

retinal degenerationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001470
Description

Detinal degenration is usually caused by the progressive cell death.
Super-classes obo:TXPO_0002590c
Restrictions obo:TXPO_0000531op some obo:PATO_0000639c
Sub-classes obo:TXPO_0003295c
obo:TXPO_0001471c

retinal degeneration [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001471
Super-classes obo:TXPO_0001716c
obo:TXPO_0001470c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c

dysfunction of sphingomyelin degradation in the myelin sheath [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001472
Super-classes obo:TXPO_0001475c
obo:TXPO_0001473c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000929c

dysfunction of sphingomyelin degradation in the myelin sheathc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001473
Super-classes obo:TXPO_0001474c
Sub-classes obo:TXPO_0001472c

dysfunction of phosphosphingolipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001474
Super-classes obo:TXPO_0001447c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001465c
Sub-classes obo:TXPO_0001473c
obo:TXPO_0001686c

dysfunction of sphingomyelin degradation [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001475
Super-classes obo:TXPO_0001687c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001476c
obo:TXPO_0000774op only obo:TXPO_0001462c
Sub-classes obo:TXPO_0003474c
obo:TXPO_0003475c
obo:TXPO_0001472c

sphingomyelin metabolism imbalance [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001476
Super-classes obo:TXPO_0001768c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001807c
obo:TXPO_0000774op only obo:TXPO_0001462c
Sub-classes obo:TXPO_0000929c
obo:TXPO_0001482c
obo:TXPO_0001816c

pulmonary infectionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001477
Super-classes obo:TXPO_0002139c
Restrictions obo:BFO_0000066op some obo:UBERON_0002048c
Sub-classes obo:TXPO_0001478c

pulmonary infection [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001478
Super-classes obo:TXPO_0001477c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001462c
Sub-classes obo:TXPO_0001814c
obo:TXPO_0001481c

decrease in platelet countc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001479
Super-classes obo:TXPO_0000348c
Restrictions obo:RO_0002234op some (obo:CL_0000233c and ub744bL61469C17c)
Sub-classes obo:TXPO_0001480c

decrease in platelet count [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001480
Super-classes obo:TXPO_0001716c
obo:TXPO_0001479c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001469c

pulmonary infection [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001481
Super-classes obo:TXPO_0001478c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c

sphingomyelin metabolism imbalance [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001482
Super-classes obo:TXPO_0001476c
Restrictions obo:BFO_0000051op some obo:TXPO_0000929c
obo:TXPO_0001733op some obo:TXPO_0002327c
obo:TXPO_0000069op some obo:TXPO_0001815c
obo:TXPO_0000774op only obo:TXPO_0001468c

hyperfunction of phospholipid removingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001483
Super-classes obo:TXPO_0002279c
Sub-classes obo:TXPO_0001484c
obo:TXPO_0004151c
obo:TXPO_0003432c

hyperfunction of phospholipid removing [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001484
Super-classes obo:TXPO_0001483c
obo:TXPO_0001716c
Restrictions obo:BFO_0000051op some obo:TXPO_0001485c
obo:TXPO_0000774op only obo:TXPO_0003452c

lysophagy [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001485
Super-classes obo:TXPO_0001716c
obo:GO_0062093c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

hyperfunction of immune responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001486
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0006955c
Sub-classes obo:TXPO_0002141c
obo:TXPO_0001487c

hyperfunction of immune response [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001487
Super-classes obo:TXPO_0001716c
obo:TXPO_0001486c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0003431c
obo:RO_0000057op some obo:TXPO_0004105c
obo:BFO_0000051op some obo:TXPO_0000334c
obo:RO_0000057op some obo:TXPO_0003586c
obo:TXPO_0000069op some obo:TXPO_0001488c

inflammatory response [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001488
Super-classes obo:TXPO_0000192c
obo:TXPO_0001716c
Restrictions obo:BFO_0000051op some obo:TXPO_0000156c
obo:RO_0000057op some obo:TXPO_0004072c
obo:BFO_0000051op some obo:TXPO_0002265c
obo:RO_0000057op some obo:TXPO_0001138c
obo:RO_0000057op some obo:TXPO_0001143c
obo:RO_0000057op some obo:TXPO_0002290c
obo:TXPO_0000069op some obo:TXPO_0001850c
obo:BFO_0000051op some obo:TXPO_0004113c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000066op some obo:UBERON_0002107c

regulation of cell cycle [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001489
Super-classes obo:TXPO_0001716c
obo:GO_0051726c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002276c
obo:RO_0000057op some obo:TXPO_0002268c
obo:TXPO_0000069op some obo:TXPO_0001491c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001490c
obo:RO_0000057op some obo:TXPO_0002249c

cell proliferation [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001490
Super-classes obo:GO_0008283c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0001137c
obo:RO_0000057op some obo:TXPO_0002244c
obo:BFO_0000051op some obo:TXPO_0003415c
obo:BFO_0000051op some obo:TXPO_0003422c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0002281c
obo:BFO_0000051op some obo:TXPO_0003418c
obo:TXPO_0000069op some obo:TXPO_0002276c

tumor cell proliferation [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001491
Super-classes obo:TXPO_0000339c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0004106c
obo:RO_0000057op some obo:TXPO_0003531c
obo:BFO_0000051op some obo:TXPO_0003423c
obo:RO_0000057op some obo:TXPO_0002294c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0003421c
obo:RO_0000057op some obo:TXPO_0003262c
obo:RO_0000057op some obo:TXPO_0003280c
obo:RO_0000057op some obo:TXPO_0001137c
obo:RO_0000057op some obo:TXPO_0003349c
obo:RO_0000057op some obo:TXPO_0002244c
obo:RO_0000057op some obo:TXPO_0004070c
obo:RO_0000057op some obo:TXPO_0003558c
obo:RO_0000057op some obo:TXPO_0003559c
obo:BFO_0000051op some obo:TXPO_0003416c
obo:RO_0000057op some obo:TXPO_0001175c

EGFR signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001492
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0001868op some obo:IMR_0000081c
obo:TXPO_0002524op some obo:GO_0007173c
Sub-classes obo:TXPO_0001493c
obo:TXPO_0004526c

EGFR signaling (primitive) [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001493
Super-classes obo:TXPO_0001716c
obo:TXPO_0001492c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001495c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001175c
obo:RO_0000057op some obo:TXPO_0001798c
obo:RO_0000057op some obo:TXPO_0001137c
Sub-classes obo:TXPO_0003423c
obo:TXPO_0003422c

AKT signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001494
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0043491c
obo:RO_0000057op some obo:IMR_0000250c
Sub-classes obo:TXPO_0004417c
obo:TXPO_0001796c

phosphatidylinositol 3-kinase signaling (primitive) [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001495
Super-classes obo:TXPO_0001716c
obo:TXPO_0001795c
Restrictions obo:RO_0000057op some obo:TXPO_0001137c
obo:TXPO_0000069op some obo:TXPO_0001796c
obo:RO_0000057op some obo:TXPO_0001175c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001800c
obo:RO_0000057op some obo:TXPO_0001857c
Sub-classes obo:TXPO_0003418c
obo:TXPO_0003421c

moving free fatty acid to the hepatocyte [eosinogranular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001496
Super-classes obo:TXPO_0001466c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

metastasis [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001497
Super-classes obo:NCIT_C19151c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001491c
obo:RO_0000057op some obo:TXPO_0003558c
obo:RO_0000057op some obo:TXPO_0004114c
obo:RO_0000057op some obo:TXPO_0003788c
obo:RO_0000057op some obo:TXPO_0003999c
obo:RO_0000057op some obo:TXPO_0004052c
obo:RO_0000057op some obo:TXPO_0003879c
obo:RO_0000057op some obo:TXPO_0004112c
obo:RO_0000057op some obo:TXPO_0004050c
obo:RO_0000057op some obo:TXPO_0004070c

CD36 -translocator role [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001498
Super-classes obo:TXPO_0001319c
Restrictions obo:RO_0000087op some obo:TXPO_0001341c

free fatty acid transporter rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001499
Super-classes obo:TXPO_0001341c

hyperfunction of uptaking fatty acid [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001500
Super-classes obo:TXPO_0001720c
obo:TXPO_0001501c
Restrictions obo:TXPO_0001502op some obo:TXPO_0001500c
obo:RO_0000057op some obo:TXPO_0001498c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003811c

hyperfunction of uptaking fatty acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001501
Super-classes obo:TXPO_0001681c
Restrictions obo:TXPO_0001502op some obo:TXPO_0001501c
Sub-classes obo:TXPO_0001500c

findingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001503
Super-classes obo:TXPO_0000614c
Sub-classes obo:TXPO_0001507c
obo:OGMS_0000014c
In range of obo:TXPO_0001873op

SLCO2B1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001504
Description

monomeric FXR imight represss human SLCO2B1
Super-classes obo:TXPO_0000272c
Restrictions obo:TXPO_0002260op some ncicp:C107150c

changing time lengthc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001505
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000632c

ATP-BINDING cassette (ABC) transporter superfamily (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001506
Super-classes obo:TXPO_0002694c
obo:TXPO_0000276c
obo:TXPO_1000014c
Sub-classes obo:TXPO_0002615c
obo:TXPO_0002642c
obo:TXPO_0002636c
obo:TXPO_0002640c
obo:TXPO_0002635c
obo:TXPO_0002616c
obo:TXPO_0000299c
obo:TXPO_0002634c
obo:TXPO_0002631c

pathological findingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001507
Super-classes obo:TXPO_0001503c
Sub-classes obo:TXPO_0003501c
obo:TXPO_0003502c
obo:TXPO_0003627c
obo:TXPO_0003504c
obo:TXPO_0000662c
obo:TXPO_0001508c
obo:TXPO_0003524c
obo:TXPO_0003503c
obo:TXPO_0003505c

myelin figure [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001508
Super-classes obo:TXPO_0001507c
Restrictions obo:TXPO_0003500op some obo:GO_0005764c
Sub-classes obo:TXPO_0003526c

nuclear receptor familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001509
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001120c
obo:IMR_0000086c
obo:TXPO_0003120c
obo:TXPO_0003862c
obo:TXPO_0000160c
obo:IMR_0000088c
obo:IMR_0000090c
obo:TXPO_0000161c
obo:TXPO_0003121c
obo:TXPO_0003119c

tumor valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001510
Super-classes obo:TXPO_0000277c
Sub-classes obo:TXPO_0001512c
obo:TXPO_0001511c

neoplastic (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001511
Super-classes obo:TXPO_0001510c

non-neoplastic (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001512
Super-classes obo:TXPO_0001510c

signal integration systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001513
Super-classes obo:TXPO_0000603c
Sub-classes obo:TXPO_0001529c
obo:TXPO_0001750c

continuousness (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001514
Super-classes obo:TXPO_0001536c

kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001515
Description

related molecular function GO:0016301
Super-classes obo:TXPO_0000606c
Sub-classes obo:TXPO_0002299c
obo:TXPO_0001865c
obo:TXPO_0001548c
obo:TXPO_0001274c

negative regulation ofglycosylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001516
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0070085c
Sub-classes obo:TXPO_0001965c

Ang (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001517
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000283c
Sub-classes obo:TXPO_0002244c
obo:TXPO_0003280c

sequestering of triglyceride in hepatocyte (mild) [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001519
Super-classes obo:TXPO_0001522c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

changing pHc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001520
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0001247c
obo:TXPO_0000577c

sequestering of triglyceride in hepatocyte (moderate) [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001521
Super-classes obo:TXPO_0001522c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

sequestering of triglyceride in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001522
Super-classes obo:GO_0030730c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
Sub-classes obo:TXPO_0001521c
obo:TXPO_0001232c
obo:TXPO_0001519c

regulation of innate immune response [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001523
Super-classes obo:GO_0045088c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

phenobarbital [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001524
Super-classes obo:CHEBI_8069c
obo:TXPO_0000560c
Sub-classes obo:TXPO_0001767c
obo:TXPO_0000976c
obo:TXPO_0003906c
obo:TXPO_0003922c

velocity attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001525
Super-classes obo:TXPO_0001334c

natural killer cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001526
Description

lymphocyte and (capable of some natural killer cell mediated immunity) and (capable of some regulation of immune response) and (lacks_plasma_membrane_part some CD19 molecule) and (lacks_plasma_membrane_part some CD3 epsilon) and (lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1) and (lacks_plasma_membrane_part some CD14 molecule)
Super-classes obo:CL_0000542c

JNK activation by IRE1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001527
Super-classes obo:TXPO_0002828c
Sub-classes obo:TXPO_0001530c

IRE1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001528
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
obo:TXPO_0000819op some obo:OGG_3000002081c
Sub-classes obo:TXPO_0002972c
obo:TXPO_0002601c

PERK signal integration systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001529
Super-classes obo:TXPO_0001513c
Restrictions obo:RO_0002351op some obo:TXPO_0000887c
obo:RO_0002351op some obo:TXPO_0001696c
Sub-classes obo:TXPO_0001533c
obo:TXPO_0002461c

JNK activation by IRE1 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001530
Super-classes obo:TXPO_0001527c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002601c
obo:RO_0002234op some obo:TXPO_0001813c

trannscriptional repressorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001531
Super-classes obo:TXPO_0000330c
Sub-classes obo:TXPO_0003946c

AP1M2 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001532
Super-classes obo:TXPO_0001135c
obo:TXPO_1000003c
Restrictions obo:RO_0000087op some obo:TXPO_0003638c
obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000010053c

PERK-eIF2a-ATF4 signal integration systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001533
Super-classes obo:TXPO_0001529c
Restrictions obo:RO_0002351op some obo:TXPO_0001414c
obo:RO_0002351op some obo:TXPO_0001211c
Sub-classes obo:TXPO_0001575c

sorting cargo transport signalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001534
Super-classes obo:TXPO_0002578c
Sub-classes obo:TXPO_0000557c

Niemann–Pick disease type Cc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001535
Description

under construction
Super-classes obo:TXPO_0000888c
obo:TXPO_0003587c
Restrictions obo:BFO_0000051op some obo:TXPO_0001557c
obo:BFO_0000051op some obo:TXPO_0001177c
obo:TXPO_0000004op some obo:TXPO_0001538c
obo:TXPO_0003585op some obo:DOID_0070113c
obo:BFO_0000051op some obo:TXPO_0001538c
obo:TXPO_0003585op some obo:DOID_0070114c
obo:BFO_0000051op some obo:TXPO_0001556c

time attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001536
Super-classes obo:TXPO_0000305c
Sub-classes obo:TXPO_0002424c
obo:TXPO_0001514c

lysosomal cholesterol storagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001537
Super-classes obo:GO_0010878c
Restrictions obo:BFO_0000066op only obo:GO_0005764c
Sub-classes obo:TXPO_0003824c
obo:TXPO_0001538c
obo:TXPO_0000694c

lysosomal cholesterol storage [Niemann Pick Disease Type C]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001538
Super-classes obo:TXPO_0001537c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

Dysfunction of mitochondrial fatty acid beta-oxidation (severe) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001539
Super-classes obo:TXPO_0000901c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003361c

hypofunction of ATP biosynthesis [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001540
Super-classes obo:TXPO_0001722c
obo:TXPO_0001720c
Restrictions obo:BFO_0000051op some obo:TXPO_0001749c
obo:BFO_0000051op some obo:TXPO_0001748c
obo:TXPO_0000069op some obo:TXPO_0003495c
obo:TXPO_0000774op only obo:TXPO_0001155c

overeatingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001541
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0002443c
obo:TXPO_0003806c
obo:TXPO_0000950c

feeding behavior [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001542
Super-classes obo:TXPO_0001716c
obo:GO_0007631c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003824c
obo:TXPO_0000069op some obo:TXPO_0000903c
obo:TXPO_0000069op some obo:TXPO_0001315c
obo:TXPO_0000774op only obo:TXPO_0002215c

CAR -cell senescence inhibitor (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001543
Super-classes obo:TXPO_0003791c
Restrictions obo:RO_0000087op some obo:TXPO_0001139c

anandamide amidohydrolasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001544
Super-classes obo:TXPO_0003663c

hypofunction of phosphoethanolamine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001545
Super-classes obo:TXPO_0001418c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000114c
obo:RO_0002233op some obo:CHEBI_36711c

regulation of hepatocyte cell cycle [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001546
Super-classes obo:TXPO_0001580c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c
obo:TXPO_0000069op some obo:TXPO_0000739c

p53 signaling (primitive) [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001547
Super-classes obo:TXPO_0001716c
obo:TXPO_0000001c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000928c
obo:RO_0000057op some obo:TXPO_0001586c
obo:RO_0000057op some obo:TXPO_0003380c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001158c

hydroxylysine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001548
Super-classes obo:TXPO_0001515c

CYP2C19 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001549
Super-classes obo:TXPO_1000079c
obo:TXPO_0001135c
Restrictions obo:RO_0000087op some obo:TXPO_0002262c
obo:TXPO_0002260op some obo:TXPO_0001553c
obo:TXPO_0000819op some obo:OGG_3000001557c
obo:TXPO_0000756op some ncicp:C15958c

hypofunction of drug metabolism phase Ic # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001550
Super-classes obo:TXPO_0002190c

hyperfunction of drug metabolism phase I [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001551
Super-classes obo:TXPO_0002049c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0001563c
obo:RO_0000057op some obo:TXPO_0001568c
obo:RO_0000057op some obo:TXPO_0001173c
obo:RO_0000057op some obo:TXPO_0001549c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001159c
obo:TXPO_0000069op some obo:TXPO_0004117c

Cyp1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001552
Super-classes obo:TXPO_0001558c
Sub-classes obo:TXPO_1000100c
obo:TXPO_0003633c

Cyp2c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001553
Super-classes obo:TXPO_0001558c
Sub-classes obo:TXPO_1000101c
obo:TXPO_0005077c
obo:TXPO_1000080c
obo:TXPO_1000079c
obo:TXPO_0001791c
obo:TXPO_1000105c
obo:TXPO_0005076c
obo:TXPO_1000081c
obo:TXPO_1000104c
obo:TXPO_1000103c
obo:TXPO_1000102c
obo:TXPO_1000078c

Cyp3c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001554
Super-classes obo:TXPO_0001558c
Sub-classes obo:TXPO_0005078c
obo:TXPO_1000106c
obo:TXPO_1000083c
obo:TXPO_1000082c

Cyp4c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001555
Super-classes obo:TXPO_0001558c
Sub-classes obo:TXPO_1000107c
obo:TXPO_1000084c
obo:TXPO_1000108c
obo:TXPO_1000109c

hypofunction of cholesterol transport in lysosome [Niemann-Pick type C] .c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001556
Super-classes obo:TXPO_0001720c
obo:TXPO_0000731c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001177c
obo:TXPO_0000774op only obo:TXPO_0001535c

cholesterol transport gene mutation [Niemann Pick Type C]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001557
Super-classes obo:TXPO_0001167c
obo:TXPO_0001720c
Restrictions obo:TXPO_0001868op some obo:TXPO_0003283c
obo:RO_0000057op some obo:TXPO_0003285c
obo:TXPO_0000774op only obo:TXPO_0001535c
obo:TXPO_0000069op some obo:TXPO_0001556c

Cytochrome P450c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001558
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000519c
Sub-classes obo:TXPO_0000404c
obo:TXPO_0001553c
obo:TXPO_0001554c
obo:TXPO_0001555c
obo:TXPO_0001552c

drug metabolism phase I by Cytochrome P450c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001559
Super-classes obo:TXPO_0000173c
Sub-classes obo:TXPO_0000373c
obo:TXPO_0000117c
obo:TXPO_0001565c

imipramine _CAD [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001560
Super-classes obo:TXPO_0001849c
obo:CHEBI_47499c
Restrictions obo:RO_0000087op some obo:TXPO_0001426c

DNA repair agent rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001561
Super-classes obo:TXPO_0003712c

CYP2B6 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001563
Description

Orthologs of the human CYP2B6 genes can be found in other species including rats, mice, and dogs, which are termed Cyp2b1, Cyp2b10, and CYP2B11, respectively
Super-classes obo:TXPO_0001135c
obo:TXPO_1000078c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000001555c
obo:RO_0000087op some obo:TXPO_0002262c
obo:TXPO_0002260op some obo:TXPO_0001553c

amitriptyline metabolism [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001564
Super-classes obo:TXPO_0001716c
obo:TXPO_0001565c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001566c
obo:RO_0000057op some obo:TXPO_0001563c

amitriptyline metabolism phase Ic # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001565
Super-classes obo:TXPO_0001559c
Sub-classes obo:TXPO_0001564c

amitriptyline [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001566
Super-classes obo:CHEBI_2666c
obo:TXPO_0001849c

long (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001567
Super-classes obo:TXPO_0000286c

CYP2D6 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001568
Super-classes obo:TXPO_1000080c
obo:TXPO_0001135c
Restrictions obo:TXPO_0002260op some obo:TXPO_0001553c
obo:RO_0000056op some obo:TXPO_0001551c
obo:TXPO_0000819op some obo:OGG_3000001565c
obo:RO_0000087op some obo:TXPO_0002262c
obo:TXPO_0000756op some ncicp:C15958c

decreasing ceramide [sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001569
Super-classes obo:TXPO_0003601c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003445c
obo:TXPO_0000069op some obo:TXPO_0001595c
obo:TXPO_0000774op only obo:TXPO_0004157c
obo:RO_0000057op some obo:TXPO_0003543c

hepatocyte cell divisionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001570
Super-classes obo:GO_0051301c
Sub-classes obo:TXPO_0000739c

PPARalpha inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001571
Super-classes obo:TXPO_0001589c
Restrictions obo:RO_0002234op some (obo:TXPO_0000159c and ub744bL62777C17c)
Sub-classes obo:TXPO_0001618c
obo:TXPO_0002357c

ethanoleaminesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001572
Super-classes obo:IMR_0001693c
Sub-classes obo:TXPO_0001573c

ethanoleaminec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001573
Super-classes obo:TXPO_0001572c

short (value)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001574
Super-classes obo:TXPO_0000287c

PERK-eIF2a-ATF4-CHOP signal integration systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001575
Super-classes obo:TXPO_0001533c
Restrictions obo:RO_0002351op some obo:TXPO_0001429c

glycerophospholipid metabolism balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001576
Super-classes obo:TXPO_0001434c
Sub-classes obo:TXPO_0001577c
obo:TXPO_0001579c

glycerophospholipid metabolism balance [phospholipidosis - glycerophospholipid disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001577
Super-classes obo:TXPO_0001716c
obo:TXPO_0001576c

heoatocyte growthc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001578
Super-classes obo:GO_0016049c
Sub-classes obo:TXPO_0001422c

phosphatidylcholine metabolism balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001579
Super-classes obo:TXPO_0001576c

regulation of hepatocyte cell cycle [hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001580
Super-classes obo:GO_0051726c
Sub-classes obo:TXPO_0001546c

stagnatingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001581
Super-classes obo:TXPO_0000711c
Sub-classes obo:TXPO_0001345c

increasing distance between hepatocytes [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001582
Description

separating between hepatocytes [Ground glass appearance]
Super-classes obo:TXPO_0001728c
obo:TXPO_0001590c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001524c
obo:TXPO_0000069op some obo:TXPO_0001033c
obo:TXPO_0000774op only obo:TXPO_0001432c

increasing phosphatidylcholine materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001583
Super-classes obo:TXPO_0001317c

drug metabolic process [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001584
Super-classes obo:GO_0017144c
Restrictions obo:BFO_0000051op some obo:TXPO_0001593c
obo:BFO_0000051op some obo:TXPO_0001597c

phosphatidylcholine metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001585
Super-classes obo:TXPO_0001295c

Sgpl1 - apoptosis inducer (mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001586
Super-classes obo:TXPO_0003529c
Restrictions obo:RO_0000087op some obo:TXPO_0002358c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:CHEBI_68495c

hyperfunction of Phosphatidylcholine synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001587
Super-classes obo:TXPO_0001264c

ground glass appearance with Cytochrome P450 activation by phenobarbitalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001588
Super-classes obo:TXPO_0003857c
Restrictions obo:BFO_0000051op some obo:TXPO_0003860c
obo:BFO_0000051op some obo:TXPO_0000981c
obo:BFO_0000051op some obo:TXPO_0001840c
obo:BFO_0000051op some obo:TXPO_0003903c
obo:BFO_0000051op some obo:TXPO_0001026c
obo:BFO_0000051op some obo:TXPO_0000982c
obo:TXPO_0000004op some obo:TXPO_0003864c
obo:BFO_0000051op some obo:TXPO_0000948c
obo:BFO_0000051op some obo:TXPO_0001663c
obo:BFO_0000051op some obo:TXPO_0002719c
obo:BFO_0000051op some obo:TXPO_0003864c
obo:BFO_0000051op some obo:TXPO_0000934c
obo:BFO_0000051op some obo:TXPO_0000781c
Sub-classes obo:TXPO_0003866c

nuclear receptor inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001589
Super-classes obo:TXPO_0000021c
Sub-classes obo:TXPO_0001571c
obo:TXPO_0003256c

increasing distance between hepatocytesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001590
Description

separating between hepatocytes
Super-classes obo:TXPO_0001617c
Sub-classes obo:TXPO_0001582c

drug metabolism phase IIc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001591
Super-classes obo:GO_0017144c
Sub-classes obo:TXPO_0001593c

increasing phosphatidylethanolamine materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001592
Super-classes obo:TXPO_0001317c

drug metabolism phase II [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001593
Super-classes obo:TXPO_0001728c
obo:TXPO_0001591c
Restrictions obo:BFO_0000051op some obo:TXPO_0001605c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0001599c

phosphatidylethanolamine metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001594
Super-classes obo:TXPO_0001295c

negative regulation of apoptotic process [Phospholipidosis-sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001595
Super-classes obo:GO_0043066c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004157c
obo:BFO_0000051op some obo:TXPO_0001569c

hyperfunctioning of phosphatidylethanolamine synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001596
Super-classes obo:TXPO_0001264c

drug metabolism phase I [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001597
Super-classes obo:TXPO_0000173c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001593c
obo:BFO_0000051op some obo:TXPO_0000373c
obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of phosphatidylethanolamine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001598
Super-classes obo:TXPO_0001304c

xenobiotic glucuronidation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001599
Description

In the liver, bilirubin is conjugated with glucuronic acid by the enzyme glucuronyltransferase, making it soluble in water: the conjugated version is the main form of bilirubin present in the "direct" bilirubin fraction. Much of it goes into the bile and thus out into the small intestine.
Super-classes obo:GO_0052697c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0001868op some obo:TXPO_0000953c

hyperfunction of phosphatidylinositol biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001600
Super-classes obo:TXPO_0001411c
Restrictions obo:TXPO_0001502op some obo:GO_0006661c

hyperfunction of phosphatidylethanolamine biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001601
Super-classes obo:TXPO_0001411c
Restrictions obo:TXPO_0001502op some obo:GO_0006646c

hyperfunction of phosphatidylglycerol biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001602
Super-classes obo:TXPO_0001411c
Restrictions obo:TXPO_0001502op some obo:GO_0006655c

hyperfunction of phosphatidylcholine biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001603
Super-classes obo:TXPO_0001411c
Restrictions obo:TXPO_0001502op some obo:GO_0006656c

hyperfunction of phosphatidyl-L-serine biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001604
Super-classes obo:TXPO_0001411c
Restrictions obo:TXPO_0001502op some obo:GO_0006659c

glutathione conjugation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001605
Super-classes obo:TXPO_0001728c
obo:TXPO_0003991c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

increasing phosphatidylglycerol materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001606
Super-classes obo:TXPO_0001317c

gene expression of cytochrome p450 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001607
Super-classes obo:TXPO_0001611c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

phosphatidylglycerol metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001608
Super-classes obo:TXPO_0001295c

S1P -apoptosis inhibitor (inactivated state)[Phospholipidosis - positive regulation of apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001609
Super-classes obo:CHEBI_37550c
obo:TXPO_0001849c
Restrictions obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000087op some obo:CHEBI_68494c

hypofunction of phosphatidylglycerol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001610
Super-classes obo:TXPO_0001418c
Restrictions obo:RO_0002233op some obo:CHEBI_17517c
obo:TXPO_0000716op some obo:GO_0034478c

gene expression of cytochrome p450c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001611
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0001607c

hyperfunction of phosphatidylglycerol synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001612
Super-classes obo:TXPO_0001264c

smooth endoplasmic reticulum membrane organization [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001613
Super-classes obo:TXPO_0001728c
obo:TXPO_0001615c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003845c

negative regulation of phosphatidylglycerol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001614
Super-classes obo:TXPO_0001304c

smooth endoplasmic reticulum membrane organizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001615
Super-classes obo:GO_0090158c
Sub-classes obo:TXPO_0001613c
obo:TXPO_0003845c

changing colorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001616
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0001350c

increasing distance between cellsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001617
Description

separating between cells
Super-classes obo:TXPO_0000466c
Sub-classes obo:TXPO_0001590c

PPAR alpha inactivation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001618
Description

PMID:25450203
Super-classes obo:TXPO_0001571c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001126c
obo:TXPO_0000069op some obo:TXPO_0000901c
obo:TXPO_0000069op some obo:TXPO_0001858c
obo:RO_0002234op some obo:TXPO_0003022c
obo:TXPO_0000774op only obo:TXPO_0001155c

regulation of generation of precursor metabolites and energy [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001619
Super-classes obo:TXPO_0001728c
obo:GO_0043467c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000963c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0000786c
Sub-classes obo:TXPO_0003953c

phosphatidic acid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001620
Super-classes obo:GO_0046475c
Restrictions obo:RO_0002233op some obo:CHEBI_16337c

hyperfunction of drug metabolism phase I by Cytochrome P450 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001621
Super-classes obo:TXPO_0000938c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000948c
obo:TXPO_0000069op some obo:TXPO_0003902c
obo:BFO_0000066op some obo:GO_0005790c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0000937c
obo:BFO_0000051op some obo:TXPO_0003855c
obo:TXPO_0000069op some obo:TXPO_0003901c
Sub-classes obo:TXPO_0003864c
obo:TXPO_0001629c

hyperfunction of phosphatidic acid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001622
Super-classes obo:TXPO_0001411c
Restrictions obo:TXPO_0001502op some obo:GO_0006654c

hyperfunction of drug metabolism phase I by Cytochrome P450c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001623
Super-classes obo:TXPO_0002049c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001559c
Sub-classes obo:TXPO_0001629c
obo:TXPO_0001182c

hyperfunction of phosphosphingolipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001624
Super-classes obo:TXPO_0001410c
Restrictions obo:TXPO_0001502op some obo:TXPO_0001291c
Sub-classes obo:TXPO_0001625c

hyperfunction of sphingomyelin biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001625
Super-classes obo:TXPO_0001624c
Restrictions obo:TXPO_0001502op some obo:GO_0006686c

ER stress response gene expression via PERKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001626
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0000695c

hyperfunction of cytochrome p450 gene expression by phenobarbital (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001627
Super-classes obo:TXPO_0003858c
obo:TXPO_0002051c
Restrictions obo:BFO_0000051op some obo:TXPO_0000967c
obo:TXPO_0000069op some obo:TXPO_0003844c
obo:TXPO_0000774op only obo:TXPO_0001432c

increasing phosphatidic acid materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001628
Super-classes obo:TXPO_0001317c

hyperfunction of drug metabolism phase I by Cytochrome P450 (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001629
Super-classes obo:TXPO_0001623c
obo:TXPO_0001621c
obo:TXPO_0003846c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0001627c
obo:BFO_0000066op some obo:GO_0005790c
obo:TXPO_0000069op some obo:TXPO_0003850c
obo:TXPO_0000069op some obo:TXPO_0001677c

increasing phosphatidylserine materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001630
Super-classes obo:TXPO_0001317c

increasing amount of foreign substancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001631
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0001633c

PPAR alpha (canonical) [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001632
Super-classes obo:TXPO_0000159c
obo:TXPO_0003516c
Sub-classes obo:TXPO_0003022c

increasing amount of xenobioticsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001633
Super-classes obo:TXPO_0001631c
Sub-classes obo:TXPO_0001635c

acetaldehyde [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001634
Super-classes obo:CHEBI_15343c
obo:TXPO_0003508c

increasing amount of drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001635
Super-classes obo:TXPO_0001633c
Sub-classes obo:TXPO_0001637c

AMPK inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001636
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0003221c and ub744bL63503C17c)
Sub-classes obo:TXPO_0001638c

increasing amount of drug [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001637
Super-classes obo:TXPO_0001635c
obo:TXPO_0001728c
Restrictions obo:BFO_0000051op some obo:TXPO_0001714c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0001842c

AMPK inactivation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001638
Description

AMPK is sensitive to energy charge, which is activated by an increase in the ratio of AMP/ATP.
Super-classes obo:TXPO_0001720c
obo:TXPO_0001636c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001115c
obo:RO_0002234op some obo:TXPO_0001711c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0001868op some obo:TXPO_0000670c
obo:RO_0002233op some obo:TXPO_0001652c

decreasing amount of drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001639
Super-classes obo:TXPO_0000822c
Restrictions obo:BFO_0000051op some obo:GO_0017144c
Sub-classes obo:TXPO_0001647c

phosphatidylserine metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001640
Super-classes obo:TXPO_0001295c

removing myelin figure by Kupffer cell or macrophagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001641
Super-classes obo:TXPO_0000458c
Restrictions obo:RO_0000057op some obo:CL_0000235c
obo:RO_0000057op some obo:CL_0000091c
Sub-classes obo:TXPO_0001643c

phosphatidic acid metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001642
Super-classes obo:TXPO_0001295c

removing myelin figure by Kupffer cell or macrophage [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001643
Super-classes obo:TXPO_0001641c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000558c

phosphatidylinositol metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001644
Super-classes obo:TXPO_0001295c

lipid accumulation in hepatocyte [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001645
Super-classes obo:TXPO_0003623c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0001844c
obo:TXPO_0001822c

hyperfunction of Phosphatidylserine synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001646
Super-classes obo:TXPO_0001264c

decreasing amount of drug [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001647
Super-classes obo:TXPO_0001639c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0001584c

hypofunction of phosphatidylserine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001648
Super-classes obo:TXPO_0001418c
Restrictions obo:TXPO_0000716op some obo:GO_0006660c
obo:RO_0002233op some obo:CHEBI_18303c

keeping amount of drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001649
Super-classes obo:TXPO_0000414c

negative regulation of phosphatidylserine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001650
Super-classes obo:TXPO_0001304c
Sub-classes obo:TXPO_0000628c

cell rupturec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001651
Super-classes obo:TXPO_0000462c
Sub-classes obo:TXPO_0001449c

AMPK (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001652
Description

PRKAA1
Super-classes obo:TXPO_0003221c
obo:TXPO_0003516c
Restrictions obo:TXPO_0002260op some obo:TXPO_0003221c
obo:RO_0000087op some obo:TXPO_0001682c
Sub-classes obo:TXPO_0001711c

increasing phosphatidylinositol materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001653
Super-classes obo:TXPO_0001317c

hyperfunction of decreasing the amount of phenobarbital [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001654
Super-classes obo:TXPO_0003861c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003847c
obo:TXPO_0003871c

hyperfunction of phosphatidylinositol synthetic gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001655
Super-classes obo:TXPO_0001264c

chemical homeostasis imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001656
Super-classes obo:TXPO_0000568c
Sub-classes obo:TXPO_0001765c
obo:TXPO_0003488c
obo:TXPO_0001233c

hypofunction of phosphatidylinositol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001657
Super-classes obo:TXPO_0001418c
Restrictions obo:RO_0002233op some obo:CHEBI_28874c
obo:TXPO_0000716op some obo:GO_0031161c

changing balance of drug metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001658
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0001660c

negative regulation of phosphatidylinositol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001659
Super-classes obo:TXPO_0001304c
Sub-classes obo:TXPO_0000629c
obo:TXPO_0000440c

changing balance of drug metabolism [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001660
Super-classes obo:TXPO_0001658c
Restrictions obo:BFO_0000066op some obo:GO_0005790c

drug metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001661
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0001665c

hyperfunction of hosphatidic acid gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001662
Super-classes obo:TXPO_0001264c

hyperfunction of glucuronic acid conjugation for phenobarbital intermediate metabolite [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001663
Super-classes obo:TXPO_0003902c
obo:TXPO_0001227c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0000992c
obo:TXPO_0000069op some obo:TXPO_0000106c
Sub-classes obo:TXPO_0003848c
obo:TXPO_0003872c

hypofunction of phosphatidic acid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001664
Super-classes obo:TXPO_0001418c
Restrictions obo:RO_0002233op some obo:CHEBI_16337c
obo:TXPO_0000716op some obo:TXPO_0001620c

drug metabolism imbalance [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001665
Super-classes obo:TXPO_0001728c
obo:TXPO_0001661c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002068c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003860c
obo:TXPO_0001667c
obo:TXPO_0001843c

negative regulation of phosphatidic acid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001666
Super-classes obo:TXPO_0001304c

drug metabolism imbalance [Ground glass appearance (severe) - tumorigenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001667
Super-classes obo:TXPO_0001665c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001668c
obo:TXPO_0000774op only obo:TXPO_0001432c

chemcal compound accumulation in liver [Ground glass appearance (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001668
Super-classes obo:TXPO_0002068c
Restrictions obo:BFO_0000051op some obo:TXPO_0000934c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003853c

increasing sphingophopholipid materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001669
Super-classes obo:TXPO_0001314c
Sub-classes obo:TXPO_0001670c

increasing sphingomyelin materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001670
Super-classes obo:TXPO_0001669c

increasing sphingomyelin material [Phospholipidosis - genetic- sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001671
Super-classes obo:TXPO_0001794c

sphingomyelin metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001672
Super-classes obo:TXPO_0001293c
Sub-classes obo:TXPO_0004163c

increase in fatty acid inflow into hepatocyte [Phpspholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001673
Super-classes obo:TXPO_0001716c
obo:TXPO_0003492c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0001698c
obo:TXPO_0001700c

hyperfunction of sphingomyelin synthetic gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001674
Super-classes obo:TXPO_0001290c

phenobarbital accumulation in liver [Ground glass appearance (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001675
Super-classes obo:TXPO_0000934c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

hypofunction of sphingomyelin degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001676
Super-classes obo:TXPO_0001287c
Restrictions obo:TXPO_0000716op some obo:GO_0006685c
obo:RO_0002233op some obo:CHEBI_64583c
Sub-classes obo:TXPO_0004162c

smooth endoplasmic reticulum proliferation in hepatocyte (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001677
Super-classes obo:TXPO_0003903c
obo:TXPO_0001230c
Restrictions obo:TXPO_0001873op some obo:TXPO_0003542c
obo:BFO_0000051op some obo:TXPO_0003865c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0002320c
obo:BFO_0000051op some obo:TXPO_0003845c

negative regulation of sphingophopholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001678
Super-classes obo:TXPO_0001256c
Restrictions obo:RO_0002212op some obo:TXPO_0001465c
Sub-classes obo:TXPO_0001680c

ground glass appearance with hypertrophyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001679
Super-classes obo:TXPO_0001432c
Restrictions obo:BFO_0000051op some obo:TXPO_0000973c
obo:BFO_0000051op some obo:TXPO_0000972c
obo:BFO_0000051op some obo:TXPO_0000970c
obo:BFO_0000051op some obo:TXPO_0000969c
obo:BFO_0000051op some obo:TXPO_0000963c

negative regulation of sphingomyelin catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001680
Super-classes obo:TXPO_0001678c
Sub-classes obo:TXPO_0001788c

hyperfunction of moving A to the inside of Bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001681
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:TXPO_0002587c
Sub-classes obo:TXPO_0002359c
obo:TXPO_0001501c

energy sensorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001682
Super-classes obo:TXPO_0000882c

maintaining phospholipid homeostasis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001683
Super-classes obo:GO_0055091c
obo:TXPO_0000951c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003356c
obo:TXPO_0001733op some obo:TXPO_0002076c

moving drug to inside of hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001684
Super-classes obo:TXPO_0002587c
Restrictions obo:RO_0002233op some (obo:BFO_0000002c and ub744bL64040C17c)
obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0000746c

sphingomyelin disorder (genetic)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001685
Super-classes obo:TXPO_0001437c
obo:TXPO_0004157c
Restrictions obo:BFO_0000051op some obo:TXPO_0001687c
obo:BFO_0000051op some obo:TXPO_0003984c
obo:TXPO_0000004op only obo:TXPO_0001768c
obo:BFO_0000051op some obo:TXPO_0001768c
obo:BFO_0000051op some obo:TXPO_0001690c
obo:BFO_0000051op some obo:TXPO_0001688c
Sub-classes obo:TXPO_0001462c

dysfunction of sphingomyelin degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001686
Super-classes obo:TXPO_0001474c
Sub-classes obo:TXPO_0004156c

dysfunction of sphingomyelin degradation [Phospholipidosis - genetic- sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001687
Super-classes obo:TXPO_0004156c
obo:TXPO_0002069c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001768c
obo:TXPO_0000774op only obo:TXPO_0001685c
Sub-classes obo:TXPO_0001475c

sphingomyelinase gene mutation [Phospholipidosis - genetic- sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001688
Super-classes obo:TXPO_0001445c
obo:TXPO_0001463c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001685c
obo:TXPO_0000069op some obo:TXPO_0001687c
Sub-classes obo:TXPO_0001446c

increasing pressurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001689
Super-classes obo:TXPO_0000475c
Restrictions obo:TXPO_0000531op some obo:PATO_0001576c
obo:RO_0002234op some (obo:BFO_0000001c and ub744bL64126C17c)
Sub-classes obo:TXPO_0001366c
obo:TXPO_0003306c
obo:TXPO_0001359c

sphingomyelin accumulation in lysosome [Phospholipidosis - genetic- sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001690
Super-classes obo:TXPO_0003381c
obo:TXPO_0002070c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001685c
Sub-classes obo:TXPO_0001807c

sphingomyelin accumulation in lysosome of nervous systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001691
Super-classes obo:TXPO_0001764c
Sub-classes obo:TXPO_0003615c

sphingomyelin accumulation in lysosome of nervous system [Niemann Pick Disease Type A (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001692
Super-classes obo:TXPO_0003615c
obo:TXPO_0001807c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c
obo:TXPO_0000069op some obo:TXPO_0001471c
obo:TXPO_0000069op some obo:TXPO_0001818c

protein binding by NAPQIc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001693
Super-classes obo:GO_0005515c
Restrictions obo:TXPO_0001868op some obo:CHEBI_29132c
Sub-classes obo:TXPO_0001196c

chemical compound accumulation in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001694
Super-classes obo:TXPO_0000169c
Restrictions obo:BFO_0000066op only obo:UBERON_0002107c
Sub-classes obo:TXPO_0002053c
obo:TXPO_0002068c
obo:TXPO_0001234c
obo:TXPO_0001179c

chemical compound accumulation in lysosome [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001695
Super-classes obo:TXPO_0000930c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002217c
obo:TXPO_0000069op some obo:TXPO_0003824c
obo:BFO_0000051op some obo:TXPO_0003451c
obo:RO_0000057op some obo:TXPO_0001425c
obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:RO_0000057op some obo:TXPO_0000081c

PERK signal transduction systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001696
Super-classes obo:TXPO_0000634c
Restrictions obo:RO_0002351op some obo:TXPO_0001852c
obo:RO_0002351op some obo:TXPO_0001841c
Sub-classes obo:TXPO_0001713c
obo:TXPO_0001712c

glycerophospholipid accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001697
Super-classes obo:TXPO_0000281c
Restrictions obo:RO_0002233op some obo:CHEBI_37739c
Sub-classes obo:TXPO_0001707c
obo:TXPO_0003373c
obo:TXPO_0001703c
obo:TXPO_0001831c
obo:TXPO_0001701c
obo:TXPO_0001705c
obo:TXPO_0001709c

increaing in fatty acid inflow into hepatocyte [Phpspholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001698
Super-classes obo:TXPO_0001673c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001315c
obo:TXPO_0000774op only obo:TXPO_0003452c

leakingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001699
Super-classes obo:TXPO_0002588c
Sub-classes obo:TXPO_0002341c
obo:TXPO_0001380c
obo:TXPO_0001368c
obo:TXPO_0000526c
obo:TXPO_0002096c

increase in fatty acid inflow into hepatocyte [Phpspholipidosis(moderate)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001700
Super-classes obo:TXPO_0001673c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001702c
obo:TXPO_0000774op only obo:TXPO_0003369c

phosphatidic acid accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001701
Super-classes obo:TXPO_0001697c
Sub-classes obo:TXPO_0003379c

increasing phospholipid material[Phospholipidosis (moderate )]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001702
Super-classes obo:TXPO_0001762c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003369c
obo:TXPO_0000069op some obo:TXPO_0001761c
obo:RO_0000057op some obo:TXPO_0001136c

phosphatidylserine accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001703
Super-classes obo:TXPO_0001697c
Sub-classes obo:TXPO_0003378c

hyperfunction of phospholipid biosynthesis [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001704
Super-classes obo:TXPO_0000908c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003372c
obo:TXPO_0000774op only obo:TXPO_0003369c

phosphatidylcholine accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001705
Super-classes obo:TXPO_0001697c
Sub-classes obo:TXPO_0003377c

S1P inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001706
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:CHEBI_37550c and ub744bL64355C17c)
Sub-classes obo:TXPO_0001845c

phosphatidylglycerol accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001707
Super-classes obo:TXPO_0001697c
Sub-classes obo:TXPO_0003376c

hyperfunction of phospholipid biosynthesis [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001708
Super-classes obo:TXPO_0000908c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0001778c

phosphatidylethanolamine accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001709
Super-classes obo:TXPO_0001697c
Sub-classes obo:TXPO_0003375c

positive regulation of phospholipid biosynthetic process [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001710
Super-classes obo:GO_0071073c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000908c
Sub-classes obo:TXPO_0001761c
obo:TXPO_0002223c

AMPK - inactivation state (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001711
Super-classes obo:TXPO_0001652c
Restrictions obo:RO_0000087op some obo:TXPO_0001682c
obo:RO_0000086op some obo:PATO_0002355c

PERK-eIF2a signal transduction systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001712
Super-classes obo:TXPO_0001696c
Restrictions obo:RO_0002351op some obo:TXPO_0002119c
Sub-classes obo:TXPO_0001725c

PERK signal transduction system [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001713
Super-classes obo:TXPO_0001696c

moving drug to the inside of liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001714
Super-classes obo:TXPO_0000312c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001637c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0001719c

toxic course dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001715
Super-classes obo:TXPO_0000271c
Sub-classes obo:TXPO_0001987c
obo:TXPO_0001727c
obo:TXPO_0001730c
obo:TXPO_0002340c
obo:TXPO_0001728c
obo:TXPO_0000889c
obo:TXPO_0001729c
obo:TXPO_0003279c
obo:TXPO_0003742c
obo:TXPO_0000034c
obo:TXPO_0003618c
obo:TXPO_0001720c
obo:TXPO_0001717c
obo:TXPO_0001716c

phospholipidosis dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001716
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0004101c
obo:TXPO_0001495c
obo:TXPO_0001257c
obo:TXPO_0001577c
obo:TXPO_0004141c
obo:TXPO_0001285c
obo:TXPO_0001796c
obo:TXPO_0000797c
obo:TXPO_0004010c
obo:TXPO_0002072c
obo:TXPO_0001480c
obo:TXPO_0001487c
obo:TXPO_0002277c
obo:TXPO_0002240c
obo:TXPO_0003445c
obo:TXPO_0003391c
obo:TXPO_0001569c
obo:TXPO_0000555c
obo:TXPO_0001817c
obo:TXPO_0001427c
obo:TXPO_0003899c
obo:TXPO_0000833c
obo:TXPO_0005189c
obo:TXPO_0001399c
obo:TXPO_0001844c
obo:TXPO_0000200c
obo:TXPO_0004117c
obo:TXPO_0000925c
obo:TXPO_0003414c
obo:TXPO_0000930c
obo:TXPO_0003386c
obo:TXPO_0001547c
obo:TXPO_0002245c
obo:TXPO_0001490c
obo:TXPO_0002227c
obo:TXPO_0003886c
obo:TXPO_0003367c
obo:TXPO_0002222c
obo:TXPO_0003595c
obo:TXPO_0004015c
obo:TXPO_0003401c
obo:TXPO_0000233c
obo:TXPO_0001489c
obo:TXPO_0002297c
obo:TXPO_0002257c
obo:TXPO_0002232c
obo:TXPO_0003394c
obo:TXPO_0000923c
obo:TXPO_0001542c
obo:TXPO_0004088c
obo:TXPO_0000664c
obo:TXPO_0003397c
obo:TXPO_0001788c
obo:TXPO_0000909c
obo:TXPO_0002095c
obo:TXPO_0003390c
obo:TXPO_0003387c
obo:TXPO_0003400c
obo:TXPO_0003384c
obo:TXPO_0003877c
obo:TXPO_0003403c
obo:TXPO_0000912c
obo:TXPO_0002264c
obo:TXPO_0004040c
obo:TXPO_0002219c
obo:TXPO_0001752c
obo:TXPO_0000905c
obo:TXPO_0001523c
obo:TXPO_0004113c
obo:TXPO_0000010c
obo:TXPO_0002083c
obo:TXPO_0002097c
obo:TXPO_0004001c
obo:TXPO_0002094c
obo:TXPO_0002255c
obo:TXPO_0003431c
obo:TXPO_0000928c
obo:TXPO_0002276c
obo:TXPO_0003593c
obo:TXPO_0004053c
obo:TXPO_0000903c
obo:TXPO_0004132c
obo:TXPO_0002258c
obo:TXPO_0003448c
obo:TXPO_0003404c
obo:TXPO_0002220c
obo:TXPO_0001400c
obo:TXPO_0003352c
obo:TXPO_0004065c
obo:TXPO_0002281c
obo:TXPO_0001853c
obo:TXPO_0004153c
obo:TXPO_0004069c
obo:TXPO_0001564c
obo:TXPO_0002239c
obo:TXPO_0000921c
obo:TXPO_0002252c
obo:TXPO_0001294c
obo:TXPO_0001811c
obo:TXPO_0001845c
obo:TXPO_0003385c
obo:TXPO_0001439c
obo:TXPO_0000950c
obo:TXPO_0003358c
obo:TXPO_0002233c
obo:TXPO_0004111c
obo:TXPO_0004144c
obo:TXPO_0001850c
obo:TXPO_0001416c
obo:TXPO_0003354c
obo:TXPO_0000918c
obo:TXPO_0000917c
obo:TXPO_0000908c
obo:TXPO_0003410c
obo:TXPO_0001491c
obo:TXPO_0002238c
obo:TXPO_0000951c
obo:TXPO_0001471c
obo:TXPO_0001493c
obo:TXPO_0000927c
obo:TXPO_0001673c
obo:TXPO_0001772c
obo:TXPO_0004085c
obo:TXPO_0003395c
obo:TXPO_0001551c
obo:TXPO_0000946c
obo:TXPO_0002071c
obo:TXPO_0000636c
obo:TXPO_0000915c
obo:TXPO_0001320c
obo:TXPO_0001497c
obo:TXPO_0001485c
obo:TXPO_0000694c
obo:TXPO_0004139c
obo:TXPO_0002085c
obo:TXPO_0003548c
obo:TXPO_0004034c
obo:TXPO_0004049c
obo:TXPO_0000494c
obo:TXPO_0000539c
obo:TXPO_0000910c
obo:TXPO_0002234c
obo:TXPO_0002241c
obo:TXPO_0003332c
obo:TXPO_0001488c
obo:TXPO_0000841c
obo:TXPO_0004146c
obo:TXPO_0000836c
obo:TXPO_0001818c
obo:TXPO_0003596c
obo:TXPO_0001406c
obo:TXPO_0004148c
obo:TXPO_0002242c
obo:TXPO_0000913c
obo:TXPO_0001478c
obo:TXPO_0002226c
obo:TXPO_0000717c
obo:TXPO_0001298c
obo:TXPO_0001463c
obo:TXPO_0003579c
obo:TXPO_0004032c
obo:TXPO_0000073c
obo:TXPO_0001484c
obo:TXPO_0001431c
obo:TXPO_0001262c
obo:TXPO_0001762c
obo:TXPO_0000101c
obo:TXPO_0003590c
obo:TXPO_0000911c
obo:TXPO_0002079c
obo:TXPO_0004123c
obo:TXPO_0003363c
obo:TXPO_0002278c
obo:TXPO_0004084c
obo:TXPO_0003436c
obo:TXPO_0000902c
obo:TXPO_0001315c
obo:TXPO_0003580c
obo:TXPO_0001645c
obo:TXPO_0003889c
obo:TXPO_0001595c
obo:TXPO_0000156c
obo:TXPO_0001643c
obo:TXPO_0002078c
obo:TXPO_0003589c
obo:TXPO_0000821c
obo:TXPO_0002265c
obo:TXPO_0003366c

ER stress dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001717
Super-classes obo:TXPO_0001715c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0000397c
obo:TXPO_0000732c
obo:TXPO_0001965c
obo:TXPO_0000456c
obo:TXPO_0002762c
obo:TXPO_0002992c
obo:TXPO_0001810c
obo:TXPO_0000206c
obo:TXPO_0003110c
obo:TXPO_0000733c
obo:TXPO_0000745c
obo:TXPO_0002925c
obo:TXPO_0002806c
obo:TXPO_0000250c
obo:TXPO_0002163c
obo:TXPO_0002171c
obo:TXPO_0000390c
obo:TXPO_0002775c
obo:TXPO_0002987c
obo:TXPO_0000758c
obo:TXPO_0000569c
obo:TXPO_0002766c
obo:TXPO_0002633c
obo:TXPO_0002499c
obo:TXPO_0002200c
obo:TXPO_0000342c
obo:TXPO_0002503c
obo:TXPO_0000413c
obo:TXPO_0000371c
obo:TXPO_0000376c
obo:TXPO_0002203c
obo:TXPO_0003008c
obo:TXPO_0001455c
obo:TXPO_0001977c
obo:TXPO_0001826c
obo:TXPO_0002536c
obo:TXPO_0000817c
obo:TXPO_0002849c
obo:TXPO_0000728c
obo:TXPO_0001959c
obo:TXPO_0000691c
obo:TXPO_0002161c
obo:TXPO_0003014c
obo:TXPO_0000450c
obo:TXPO_0002618c
obo:TXPO_0000735c
obo:TXPO_0002539c
obo:TXPO_0000686c
obo:TXPO_0000513c
obo:TXPO_0002811c
obo:TXPO_0000402c
obo:TXPO_0002188c
obo:TXPO_0002117c
obo:TXPO_0002412c
obo:TXPO_0002116c
obo:TXPO_0002194c
obo:TXPO_0000403c
obo:TXPO_0002101c
obo:TXPO_0002533c
obo:TXPO_0000204c
obo:TXPO_0002916c
obo:TXPO_0002477c
obo:TXPO_0000752c
obo:TXPO_0002847c
obo:TXPO_0000762c
obo:TXPO_0002529c
obo:TXPO_0000695c
obo:TXPO_0000386c
obo:TXPO_0001956c
obo:TXPO_0003736c
obo:TXPO_0003105c
obo:TXPO_0002197c
obo:TXPO_0002696c
obo:TXPO_0002544c
obo:TXPO_0000517c
obo:TXPO_0003210c
obo:TXPO_0000767c
obo:TXPO_0000452c
obo:TXPO_0000061c
obo:TXPO_0001311c
obo:TXPO_0002505c
obo:TXPO_0002547c
obo:TXPO_0002747c
obo:TXPO_0002473c
obo:TXPO_0000734c
obo:TXPO_0002449c
obo:TXPO_0002114c
obo:TXPO_0000748c
obo:TXPO_0002532c
obo:TXPO_0002504c
obo:TXPO_0000123c
obo:TXPO_0000074c
obo:TXPO_0002201c
obo:TXPO_0002534c
obo:TXPO_0002384c
obo:TXPO_0000764c
obo:TXPO_0000214c
obo:TXPO_0002479c
obo:TXPO_0001245c
obo:TXPO_0000170c
obo:TXPO_0000194c
obo:TXPO_0000818c
obo:TXPO_0002788c
obo:TXPO_0002440c
obo:TXPO_0002175c
obo:TXPO_0003017c
obo:TXPO_0002475c
obo:TXPO_0003276c
obo:TXPO_0003016c
obo:TXPO_0002172c
obo:TXPO_0002830c
obo:TXPO_0002209c
obo:TXPO_0002751c
obo:TXPO_0002746c
obo:TXPO_0000693c
obo:TXPO_0002731c
obo:TXPO_0003490c
obo:TXPO_0000037c
obo:TXPO_0002207c
obo:TXPO_0000516c
obo:TXPO_0003059c
obo:TXPO_0002741c
obo:TXPO_0002199c
obo:TXPO_0002191c
obo:TXPO_0003270c
obo:TXPO_0002535c
obo:TXPO_0000760c
obo:TXPO_0002210c
obo:TXPO_0000831c
obo:TXPO_0002204c
obo:TXPO_0002177c
obo:TXPO_0000730c
obo:TXPO_0000147c
obo:TXPO_0003598c
obo:TXPO_0002716c
obo:TXPO_0002502c
obo:TXPO_0002113c
obo:TXPO_0000770c
obo:TXPO_0003554c
obo:TXPO_0002805c
obo:TXPO_0000722c
obo:TXPO_0002538c
obo:TXPO_0000383c
obo:TXPO_0002469c
obo:TXPO_0002990c

malfunctioning of hepatic blood circulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001718
Super-classes obo:TXPO_0000434c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001366c
obo:TXPO_0000069op some obo:TXPO_0001358c
obo:TXPO_0000069op some obo:TXPO_0001359c
Sub-classes obo:TXPO_0003617c

moving phenobarbital to the inside of liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001719
Super-classes obo:TXPO_0001714c
obo:TXPO_0001728c
Restrictions obo:RO_0000057op some obo:TXPO_0001524c
obo:TXPO_0000774op only obo:TXPO_0001432c

hepatic steatosis dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001720
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
Sub-classes obo:TXPO_0001273c
obo:TXPO_0001748c
obo:TXPO_0001065c
obo:TXPO_0001500c
obo:TXPO_0003799c
obo:TXPO_0001036c
obo:TXPO_0003808c
obo:TXPO_0001457c
obo:TXPO_0001056c
obo:TXPO_0001386c
obo:TXPO_0001132c
obo:TXPO_0001267c
obo:TXPO_0001970c
obo:TXPO_0001747c
obo:TXPO_0000897c
obo:TXPO_0001284c
obo:TXPO_0001864c
obo:TXPO_0003487c
obo:TXPO_0003480c
obo:TXPO_0000892c
obo:TXPO_0001115c
obo:TXPO_0000861c
obo:TXPO_0003495c
obo:TXPO_0000900c
obo:TXPO_0001221c
obo:TXPO_0001085c
obo:TXPO_0000860c
obo:TXPO_0001557c
obo:TXPO_0001121c
obo:TXPO_0001371c
obo:TXPO_0001556c
obo:TXPO_0001174c
obo:TXPO_0000862c
obo:TXPO_0001131c
obo:TXPO_0001390c
obo:TXPO_0001973c
obo:TXPO_0001745c
obo:TXPO_0001618c
obo:TXPO_0001100c
obo:TXPO_0001153c
obo:TXPO_0003809c
obo:TXPO_0003510c
obo:TXPO_0001117c
obo:TXPO_0003622c
obo:TXPO_0001259c
obo:TXPO_0000901c
obo:TXPO_0001083c
obo:TXPO_0001141c
obo:TXPO_0001059c
obo:TXPO_0003807c
obo:TXPO_0001049c
obo:TXPO_0001150c
obo:TXPO_0001086c
obo:TXPO_0003496c
obo:TXPO_0000899c
obo:TXPO_0003478c
obo:TXPO_0000891c
obo:TXPO_0000279c
obo:TXPO_0001858c
obo:TXPO_0002357c
obo:TXPO_0003806c
obo:TXPO_0001856c
obo:TXPO_0000898c
obo:TXPO_0000050c
obo:TXPO_0001163c
obo:TXPO_0001129c
obo:TXPO_0001218c
obo:TXPO_0003361c
obo:TXPO_0000890c
obo:TXPO_0001095c
obo:TXPO_0001638c
obo:TXPO_0003756c
obo:TXPO_0001126c
obo:TXPO_0001540c
obo:TXPO_0001749c
obo:TXPO_0001116c
obo:TXPO_0003497c
obo:TXPO_0001118c
obo:TXPO_0001246c
obo:TXPO_0003787c
obo:TXPO_0003511c
obo:TXPO_0001160c
obo:TXPO_0001220c
obo:TXPO_0000859c
obo:TXPO_0001113c
obo:TXPO_0001379c
obo:TXPO_0003482c
obo:TXPO_0003620c
obo:TXPO_0001078c
obo:TXPO_0003512c
obo:TXPO_0001882c
obo:TXPO_0004128c
obo:TXPO_0001522c
obo:TXPO_0001130c
obo:TXPO_0003264c
obo:TXPO_0001458c
obo:TXPO_0001170c
obo:TXPO_0001878c
obo:TXPO_0001087c
obo:TXPO_0001281c
obo:TXPO_0003494c
obo:TXPO_0003507c
obo:TXPO_0001538c
obo:TXPO_0001890c
obo:TXPO_0003621c
obo:TXPO_0001744c
obo:TXPO_0001894c
obo:TXPO_0003484c

MMP inactivation by TIMP1 [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001721
Super-classes obo:TXPO_0003742c
obo:TXPO_0001384c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
obo:RO_0000057op some obo:TXPO_0003062c

hypofunction of ATP biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001722
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000716op some obo:GO_0006754c
Sub-classes obo:TXPO_0002209c
obo:TXPO_0001540c
obo:TXPO_0000605c
obo:TXPO_0001203c
obo:TXPO_0000346c
obo:TXPO_0002230c
obo:TXPO_0002234c

hypofunction of phospholipid deradation by phospholipasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001723
Super-classes obo:TXPO_0001253c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000635c
Sub-classes obo:TXPO_0000914c

hyperfunction of increasingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001724
Super-classes obo:TXPO_0000435c
Sub-classes obo:TXPO_0000473c
obo:TXPO_0001825c

PERK-eIF2a signal transduction systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001725
Super-classes obo:TXPO_0001712c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000722c
obo:RO_0002351op some obo:TXPO_0002162c

hyperfunction of phospholipid synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001726
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0000915c
obo:TXPO_0001264c
obo:TXPO_0001290c
obo:TXPO_0003385c

cell death dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001727
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
Sub-classes obo:TXPO_0000231c
obo:TXPO_0002390c
obo:TXPO_0002099c
obo:TXPO_0000377c
obo:TXPO_0002135c
obo:TXPO_0002389c
obo:TXPO_0000226c
obo:TXPO_0000241c
obo:TXPO_0003026c
obo:TXPO_0003830c
obo:TXPO_0002128c
obo:TXPO_0003235c
obo:TXPO_0000534c
obo:TXPO_0000340c
obo:TXPO_0000030c
obo:TXPO_0000355c
obo:TXPO_0000667c
obo:TXPO_0000453c
obo:TXPO_0000579c
obo:TXPO_0000486c
obo:TXPO_0000582c
obo:TXPO_0002381c
obo:TXPO_0003831c
obo:TXPO_0002403c
obo:TXPO_0003825c
obo:TXPO_0000448c
obo:TXPO_0000223c
obo:TXPO_0003344c
obo:TXPO_0003827c
obo:TXPO_0002122c
obo:TXPO_0000338c
obo:TXPO_0002129c
obo:TXPO_0000008c
obo:TXPO_0000391c
obo:TXPO_0002137c
obo:TXPO_0000573c
obo:TXPO_0003163c
obo:TXPO_0000773c
obo:TXPO_0000246c
obo:TXPO_0002138c
obo:TXPO_0000374c
obo:TXPO_0002140c
obo:TXPO_0003829c
obo:TXPO_0000527c
obo:TXPO_0000574c
obo:TXPO_0002125c
obo:TXPO_0002409c
obo:TXPO_0000446c
obo:TXPO_0000252c
obo:TXPO_0000239c
obo:TXPO_0003737c
obo:TXPO_0000541c
obo:TXPO_0003123c
obo:TXPO_0000236c
obo:TXPO_0000346c
obo:TXPO_0002388c
obo:TXPO_0001449c
obo:TXPO_0000234c
obo:TXPO_0002142c
obo:TXPO_0002141c

ground glass degeneration dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001728
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003918c
obo:TXPO_0001028c
obo:TXPO_0000181c
obo:TXPO_0000947c
obo:TXPO_0001011c
obo:TXPO_0000938c
obo:TXPO_0001619c
obo:TXPO_0001033c
obo:TXPO_0003795c
obo:TXPO_0001582c
obo:TXPO_0003793c
obo:TXPO_0003961c
obo:TXPO_0000978c
obo:TXPO_0003960c
obo:TXPO_0003260c
obo:TXPO_0000941c
obo:TXPO_0001613c
obo:TXPO_0000106c
obo:TXPO_0000962c
obo:TXPO_0000971c
obo:TXPO_0003969c
obo:TXPO_0000325c
obo:TXPO_0003851c
obo:TXPO_0000955c
obo:TXPO_0000669c
obo:TXPO_0001593c
obo:TXPO_0001015c
obo:TXPO_0001013c
obo:TXPO_0000781c
obo:TXPO_0000983c
obo:TXPO_0000977c
obo:TXPO_0000969c
obo:TXPO_0000943c
obo:TXPO_0003855c
obo:TXPO_0000956c
obo:TXPO_0001607c
obo:TXPO_0000965c
obo:TXPO_0003597c
obo:TXPO_0000959c
obo:TXPO_0003919c
obo:TXPO_0002600c
obo:TXPO_0000803c
obo:TXPO_0001838c
obo:TXPO_0001665c
obo:TXPO_0000982c
obo:TXPO_0001719c
obo:TXPO_0000954c
obo:TXPO_0001605c
obo:TXPO_0001031c
obo:TXPO_0001597c
obo:TXPO_0000963c
obo:TXPO_0003790c
obo:TXPO_0001827c
obo:TXPO_0000936c
obo:TXPO_0001714c
obo:TXPO_0003958c
obo:TXPO_0003258c
obo:TXPO_0001637c
obo:TXPO_0001647c
obo:TXPO_0000981c
obo:TXPO_0000443c
obo:TXPO_0000937c
obo:TXPO_0003859c
obo:TXPO_0003904c
obo:TXPO_0000958c
obo:TXPO_0000945c
obo:TXPO_0003951c
obo:TXPO_0001018c
obo:TXPO_0002068c
obo:TXPO_0003956c
obo:TXPO_0000948c
obo:TXPO_0000980c
obo:TXPO_0003926c
obo:TXPO_0003936c
obo:TXPO_0000972c
obo:TXPO_0000973c
obo:TXPO_0000092c
obo:TXPO_0003852c
obo:TXPO_0003796c
obo:TXPO_0000597c
obo:TXPO_0000942c
obo:TXPO_0003921c
obo:TXPO_0000373c
obo:TXPO_0001006c
obo:TXPO_0003905c
obo:TXPO_0000961c
obo:TXPO_0001052c
obo:TXPO_0002319c
obo:TXPO_0001026c
obo:TXPO_0003942c
obo:TXPO_0000964c
obo:TXPO_0000970c
obo:TXPO_0001030c
obo:TXPO_0000952c

eosinophlic granular degeneration dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001729
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
Sub-classes obo:TXPO_0000182c
obo:TXPO_0000118c
obo:TXPO_0003207c
obo:TXPO_0000746c
obo:TXPO_0002021c
obo:TXPO_0000174c
obo:TXPO_0003232c
obo:TXPO_0000116c
obo:TXPO_0000198c
obo:TXPO_0002100c
obo:TXPO_0000479c
obo:TXPO_0000096c
obo:TXPO_0000196c
obo:TXPO_0002047c
obo:TXPO_0000130c
obo:TXPO_0000136c
obo:TXPO_0002173c
obo:TXPO_0001496c
obo:TXPO_0001005c
obo:TXPO_0000110c
obo:TXPO_0000151c
obo:TXPO_0000146c
obo:TXPO_0000190c
obo:TXPO_0003219c
obo:TXPO_0000128c
obo:TXPO_0000103c
obo:TXPO_0000127c
obo:TXPO_0000191c
obo:TXPO_0000109c
obo:TXPO_0000176c
obo:TXPO_0000165c
obo:TXPO_0002134c
obo:TXPO_0003231c
obo:TXPO_0000149c
obo:TXPO_0000184c
obo:TXPO_0000153c
obo:TXPO_0000179c
obo:TXPO_0000105c
obo:TXPO_0000187c

oxidative stress dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001730
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c
Sub-classes obo:TXPO_0000605c
obo:TXPO_0000536c
obo:TXPO_0000467c
obo:TXPO_0000546c
obo:TXPO_0000042c
obo:TXPO_0000542c
obo:TXPO_0000515c
obo:TXPO_0000566c
obo:TXPO_0000815c
obo:TXPO_0000842c
obo:TXPO_0000461c
obo:TXPO_0001186c
obo:TXPO_0000455c
obo:TXPO_0000814c
obo:TXPO_0000543c
obo:TXPO_0002333c

toxic course dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001731
Super-classes obo:CHEBI_24431c
Sub-classes obo:TXPO_0000794c
obo:TXPO_0003749c
obo:TXPO_0001089c
obo:TXPO_0000835c
obo:TXPO_0002012c
obo:TXPO_0000838c
obo:TXPO_0001133c
obo:TXPO_0000199c
obo:TXPO_0000984c
obo:TXPO_0000297c
obo:TXPO_0000273c
obo:TXPO_0001915c

ATF6 signal transduction systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001732
Super-classes obo:TXPO_0000634c

balance statec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001734
Super-classes obo:TXPO_0000270c

imbalance statec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001735
Super-classes obo:TXPO_0000270c

state of functional supplyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001736
Super-classes obo:TXPO_0000270c

cell part damagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001737
Super-classes obo:TXPO_0000222c
Sub-classes obo:TXPO_0001738c

membrane damagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001738
Super-classes obo:TXPO_0001737c

dysfunction of mitochondrial fatty acid degradation [Alchoric fatty liver]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001739
Super-classes obo:TXPO_0000901c
obo:TXPO_0003652c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0000279c
obo:BFO_0000066op some obo:GO_0005739c

very high levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001740
Super-classes obo:TXPO_0004208c

dysfunction of lipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001741
Super-classes obo:TXPO_0000438c
Restrictions obo:TXPO_0000716op some obo:GO_0009395c
obo:RO_0002233op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0001447c
obo:TXPO_0003652c

medium levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001742
Super-classes obo:TXPO_0004208c

low levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001743
Super-classes obo:TXPO_0004208c

inflammasome activation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001744
Super-classes obo:TXPO_0001107c
obo:TXPO_0001720c
Restrictions obo:RO_0000057op some obo:TXPO_0001104c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0000057op some obo:TXPO_0001876c
obo:RO_0000057op some obo:TXPO_0001886c
obo:TXPO_0000069op some obo:TXPO_0001065c

oxidative phosphorylation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001745
Super-classes obo:TXPO_0001720c
obo:GO_0006119c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c

functional demand statec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001746
Super-classes obo:TXPO_0000270c

malfunctioning of mitochondrial ATP synthesis coupled electron transfer [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001747
Super-classes obo:TXPO_0001720c
obo:TXPO_0001846c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c

negative regulation of respiratory electron transport chain [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001748
Super-classes obo:TXPO_0001720c
obo:TXPO_0002342c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0001540c
obo:RO_0000057op some obo:TXPO_0002019c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0000057op some obo:TXPO_0002026c
obo:RO_0000057op some obo:TXPO_0002030c

negative regulation of oxidative phosphorylation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001749
Super-classes obo:TXPO_0001771c
obo:TXPO_0001720c
Restrictions obo:RO_0002212op some obo:GO_0006119c
obo:TXPO_0000069op some obo:TXPO_0001540c
obo:RO_0000057op some obo:TXPO_0002043c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0000057op some obo:TXPO_0002036c

ATF6 signal integration systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001750
Super-classes obo:TXPO_0001513c
Sub-classes obo:TXPO_0001760c

NAPQI accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001751
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_29132c
Sub-classes obo:TXPO_0001192c

hypofunction of maintaining lysosome homeostasis [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001752
Super-classes obo:TXPO_0001297c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000470c
obo:TXPO_0000774op only obo:TXPO_0002215c

preventingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001753
Super-classes obo:TXPO_0000600c

providingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001754
Super-classes obo:TXPO_0000600c

abnormality of membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001755
Super-classes obo:TXPO_0001770c
Sub-classes obo:TXPO_0001205c
obo:TXPO_0002381c
obo:TXPO_0000542c

drivingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001756
Super-classes obo:TXPO_0000600c

enablingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001757
Super-classes obo:TXPO_0000600c
Sub-classes obo:TXPO_0002617c

cytochrome P450 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001758
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_0001558c and ub744bL64954C17c)
Sub-classes obo:TXPO_0001183c
obo:TXPO_0003799c

importing substances into hepatocyte vascular side (sinusoidal side) membrane [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001759
Description

Bile contains bile acids, glutathione, phospholipids, cholesterol, bilirubin, and other organic anions, proteins, metals, ions, and xenobiotics.

Hepatocytes begins the formation of bile by transporting bile acids, glutathione, and other solutes including Xenobiotics and their metabolites into the canalicular lumen.

The major driving force of bile formation is the active transport of bile salts and other osmolytes into the canalicular lumen.

Most conjugated bile acids (taurine and glycine conjugates) and some unconjugated bile acids are transported into hepatocytes by sodium-dependent transporters.

Sodium-independent uptake of conjugated and unconjugated bile acids is performed by members of the organic anion-transporting polypeptides (OATPs). OATPs also transport numerous drugs and hepatotoxicants.

Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids.

Conjugates of glutathione, glucuronide, and sulfate are exported by multidrug resistance-associated protein2 (MRP2).
Super-classes obo:TXPO_0003124c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
Sub-classes obo:TXPO_0002150c
obo:TXPO_0002698c
obo:TXPO_0001783c
obo:TXPO_0002639c

ATF6-CHOP signal integration systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001760
Super-classes obo:TXPO_0001750c

positive regulation of phospholipid biosynthetic process [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001761
Super-classes obo:TXPO_0001710c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001704c

increasing phospholipid material[Phospholipidosis ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001762
Super-classes obo:TXPO_0001314c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001761c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001136c
Sub-classes obo:TXPO_0001315c
obo:TXPO_0001702c

sphingophospholipid accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001763
Super-classes obo:TXPO_0000281c
Restrictions obo:RO_0002233op some obo:CHEBI_35786c
Sub-classes obo:TXPO_0001764c

sphingomyelin accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001764
Super-classes obo:TXPO_0001763c
Sub-classes obo:TXPO_0003381c
obo:TXPO_0001691c

calcium ion homeostasis imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001765
Super-classes obo:TXPO_0001656c
Sub-classes obo:TXPO_0001206c
obo:TXPO_0000566c
obo:TXPO_0004348c

hypofunction of xenobiotic glucuronidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001766
Super-classes obo:TXPO_0002190c

phenobarbital - tumor promoting factor [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001767
Super-classes obo:TXPO_0001524c
Restrictions obo:RO_0000087op some obo:TXPO_0002272c

sphingomyelin metabolism imbalance [Phospholipidosis - genetic- sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001768
Super-classes obo:TXPO_0001776c
obo:TXPO_0001823c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001685c
obo:TXPO_0000069op some obo:TXPO_0001690c
Sub-classes obo:TXPO_0001476c

hypofunction of phospholipase transport to lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001769
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000002c
Sub-classes obo:TXPO_0000911c

changing abnormal cellular structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001770
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0001755c
obo:TXPO_0000902c
obo:TXPO_0004757c

negative regulation of oxidative phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001771
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006119c
Sub-classes obo:TXPO_0004125c
obo:TXPO_0001749c

keeping amount of phospholipid in lysosome (normal condition) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001772
Super-classes obo:TXPO_0001716c
obo:TXPO_0003358c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001683c
obo:BFO_0000051op some obo:TXPO_0003386c
obo:BFO_0000051op some obo:TXPO_0002085c
obo:TXPO_0000774op only obo:TXPO_0002215c

glutathione deficiencyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001773
Super-classes obo:TXPO_0000482c

ALAS1 (human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001774
Description

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis.
Super-classes obo:TXPO_0001090c
obo:TXPO_1000034c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000211c
obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000756op some ncicp:C15958c

hypofunction of glutathione conjugationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001775
Super-classes obo:TXPO_0002190c
Sub-classes obo:TXPO_0003288c

phospholipid metabolism imbalance [Phospholipidosis - genetic]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001776
Super-classes obo:TXPO_0002324c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001437c
obo:TXPO_0001733op some (obo:TXPO_0000493c or obo:TXPO_0002327c)
obo:TXPO_0000716op some obo:TXPO_0001435c
obo:TXPO_0000069op some obo:TXPO_0002070c
Sub-classes obo:TXPO_0001768c

phospholipid metabolism imbalance [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001777
Super-classes obo:TXPO_0002324c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004155c
obo:TXPO_0000774op only obo:TXPO_0003359c
obo:TXPO_0001733op some obo:TXPO_0000493c
obo:TXPO_0000716op some obo:TXPO_0001435c
obo:TXPO_0000069op some obo:TXPO_0001824c

phospholipid metabolism imbalance [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001778
Super-classes obo:TXPO_0002324c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000920c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000716op some obo:TXPO_0001435c
obo:TXPO_0000069op some obo:TXPO_0003435c
obo:TXPO_0001733op some (obo:TXPO_0000679c or obo:TXPO_0001779c)

toxicological imbalance VH (toxic action)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001779
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some obo:TXPO_0001735c
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL65269C17c)
Sub-classes obo:TXPO_0001781c
obo:TXPO_0001208c

toxicological balance H=H (maintining homeostasis at higher level)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001780
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL65308C17c and obo:TXPO_0001746c and ub744bL65330C17c)
obo:BFO_0000051op some obo:TXPO_0001734c
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL65308C17c and obo:TXPO_0001746c and ub744bL65330C17c)

toxicological imbalance Hc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001781
Super-classes obo:TXPO_0001779c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001746c and ub744bL65391C17c and obo:TXPO_0001736c and ub744bL65369C17c)
obo:BFO_0000051op some (obo:TXPO_0001746c and ub744bL65391C17c and obo:TXPO_0001736c and ub744bL65369C17c)
obo:BFO_0000051op some obo:TXPO_0001735c

phospholipid metabolism balance [Phospholipidosis (adaptation)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001782
Super-classes obo:TXPO_0001434c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0001733op some obo:TXPO_0001780c

importing anion into hepatocyte vascular side (sinusoidal side) membrane [cholestasis] [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001783
Description

Uptake of bile salts from sinusoidal blood into hepatocyte is predominantly sodium dependent
Super-classes obo:TXPO_0001759c
Sub-classes obo:TXPO_0001869c
obo:TXPO_0001784c

organic anion import into hepatocyte vascular side (sinusoidal side) membrane [cholestasis] [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001784
Description

Uptake of bile salts from sinusoidal blood into hepatocyte is predominantly sodium dependent, whichi is mediated by the NTCP (sodium/bile acid cotransporter; SLC10A1) in a polar manner at the basolateral plasma membrane of hepatocytes
Super-classes obo:TXPO_0001783c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000547c

sphingomyelin phosphodiesterasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001785
Super-classes obo:TXPO_0003672c

lipidosis marker genec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001786
Super-classes obo:TXPO_0001090c
Sub-classes obo:TXPO_0001808c
obo:TXPO_0001099c
obo:TXPO_0004007c
obo:TXPO_0003915c
obo:TXPO_0001102c
obo:TXPO_0001888c

negative regulation of enzyme activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001787
Super-classes obo:TXPO_0000369c
Sub-classes obo:TXPO_0005029c

negative regulation of sphingomyelin catabolic process [sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001788
Super-classes obo:TXPO_0001716c
obo:TXPO_0001680c
obo:TXPO_0000905c
Restrictions obo:RO_0000057op some obo:TXPO_0000318c
obo:TXPO_0000069op some obo:TXPO_0004162c

SPON2(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001789
Super-classes obo:TXPO_0001135c
obo:TXPO_0003834c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010417c
Sub-classes obo:TXPO_0004114c
obo:TXPO_0004116c

increasing free radicalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001790
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004258c
obo:TXPO_0000467c
obo:TXPO_0001199c

CYP2C8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001791
Super-classes obo:TXPO_0001553c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001555c
Sub-classes obo:TXPO_0001808c

PERK (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001792
Description

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009451c
obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:TXPO_0002880c
obo:TXPO_0000301c
obo:TXPO_0000878c

generating signal [Signaling pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001793
Super-classes obo:TXPO_0000011c

increasing glycerophospholipid material [Phospholipidosis - sphingophospholipid disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001794
Super-classes obo:TXPO_0001317c
Sub-classes obo:TXPO_0001671c

phosphatidylinositol 3-kinase signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001795
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002481c
Sub-classes obo:TXPO_0001495c

AKT signaling (primitive) [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001796
Super-classes obo:TXPO_0001716c
obo:TXPO_0001494c
Restrictions obo:TXPO_0000076op some obo:TXPO_0001495c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003229c
obo:TXPO_0000069op some obo:TXPO_0001490c
obo:RO_0000057op some obo:TXPO_0001175c
obo:RO_0000057op some obo:TXPO_0001857c
obo:RO_0000057op some obo:TXPO_0001137c
Sub-classes obo:TXPO_0003415c
obo:TXPO_0003416c

G6PC (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001797
Super-classes obo:TXPO_0000563c
obo:TXPO_0000472c
Restrictions obo:RO_0000087op some obo:TXPO_0003674c
Sub-classes obo:TXPO_0003927c

EGFR (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001798
Super-classes obo:TXPO_0003213c
obo:IMR_0000081c
Restrictions obo:RO_0000087op some obo:TXPO_0002271c
obo:TXPO_0002260op some obo:OGG_3000001956c
Sub-classes obo:TXPO_0003424c
obo:TXPO_0003425c

AKT (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001799
Super-classes obo:TXPO_0003213c
obo:IMR_0100844c
Restrictions obo:TXPO_0002260op some obo:IMR_0000250c
Sub-classes obo:TXPO_0002280c
obo:TXPO_0003417c
obo:TXPO_0003229c

PI3K (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001800
Super-classes obo:TXPO_0003213c
obo:TXPO_0003223c
Restrictions obo:TXPO_0002260op some obo:IMR_0000265c
Sub-classes obo:TXPO_0003419c
obo:TXPO_0003420c

P53 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001801
Super-classes obo:TXPO_0003213c
obo:IMR_0100659c
Restrictions obo:RO_0000087op some obo:TXPO_0000329c
obo:TXPO_0002260op some obo:IMR_0100659c

BMP (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001802
Super-classes obo:CHEBI_60815c
obo:TXPO_0003213c

PLA1 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001803
Super-classes obo:TXPO_0003213c
obo:TXPO_0000120c

PLA2 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001804
Super-classes obo:IMR_0000283c
obo:TXPO_0003213c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0002260op some obo:IMR_0000283c
Sub-classes obo:TXPO_0003571c

PLC (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001805
Super-classes obo:IMR_0000284c
obo:TXPO_0003213c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0002260op some obo:IMR_0000284c

M6PR (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001806
Super-classes obo:TXPO_0003213c
obo:TXPO_1000240c

severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A/ B (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001807
Super-classes obo:TXPO_0001690c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002072c
obo:TXPO_0000069op some obo:TXPO_0002263c
obo:TXPO_0000069op some obo:TXPO_0004146c
obo:RO_0000057op some obo:TXPO_0004147c
obo:TXPO_0000069op some obo:TXPO_0001478c
obo:TXPO_0000069op some obo:TXPO_0002071c
Sub-classes obo:TXPO_0001809c
obo:TXPO_0001815c
obo:TXPO_0001692c

CYP2C8 (human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001808
Super-classes obo:TXPO_0001786c
obo:TXPO_0001791c
Restrictions obo:TXPO_0002260op some obo:TXPO_0001553c
obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:TXPO_0002262c
obo:TXPO_0000819op some obo:OGG_3000001558c
obo:RO_0000086op some obo:TXPO_0000657c

severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001809
Super-classes obo:TXPO_0001807c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001814c
obo:TXPO_0000069op some obo:TXPO_0001811c
obo:TXPO_0000069op some obo:TXPO_0001480c

malfunction of mitochondria [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001810
Super-classes obo:TXPO_0001717c
obo:TXPO_0000782c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002171c
obo:TXPO_0000069op some obo:TXPO_0002209c
obo:TXPO_0000774op only obo:TXPO_0002528c

splenohepatomegaly [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001811
Super-classes obo:TXPO_0001716c
obo:TXPO_0001812c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001469c

splenohepatomegalyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001812
Super-classes obo:TXPO_0000138c
Restrictions obo:BFO_0000066op only (obo:UBERON_0002106c or obo:UBERON_0002107c)
Sub-classes obo:TXPO_0001817c
obo:TXPO_0001811c

JNK (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001813
Super-classes obo:IMR_0000225c
obo:TXPO_0000871c
obo:TXPO_1000216c
Sub-classes obo:TXPO_0002927c
obo:TXPO_0002928c
obo:TXPO_0002929c
obo:TXPO_0002930c

pulmonary infection [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001814
Super-classes obo:TXPO_0001478c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001469c

severe sphingomyelin accumulation in lysosome [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001815
Super-classes obo:TXPO_0001807c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001481c
obo:TXPO_0000069op some obo:TXPO_0001817c
obo:BFO_0000051op some obo:TXPO_0001692c

sphingomyelin metabolism imbalance [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001816
Super-classes obo:TXPO_0001476c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001809c
obo:TXPO_0000774op only obo:TXPO_0001468c

splenohepatomegaly [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001817
Super-classes obo:TXPO_0001812c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c

hypofunction of nervous system functioning [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001818
Super-classes obo:TXPO_0001819c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c

hypofunction of nervous system functioningc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001819
Super-classes obo:TXPO_0000436c
Sub-classes obo:TXPO_0001818c

system dependent functional moleculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001820
Super-classes obo:CHEBI_24431c
Sub-classes obo:TXPO_0002753c
obo:TXPO_0001821c

signal transduction system dependent moleculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001821
Super-classes obo:TXPO_0001820c
Sub-classes obo:TXPO_0001828c
obo:TXPO_0001833c
obo:TXPO_0000490c

lipid accumulation in hepatocyte [Phospholipidosis(moderate)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001822
Super-classes obo:TXPO_0001645c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001700c
obo:TXPO_0000774op only obo:TXPO_0003369c

sphingomyelin metabolism imbalance [Phospholipidosis - sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001823
Super-classes obo:TXPO_0004163c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004157c
obo:TXPO_0000069op some obo:TXPO_0003381c
Sub-classes obo:TXPO_0001768c

phospholipid accumulation in lysosome [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001824
Super-classes obo:TXPO_0000910c
Restrictions obo:RO_0000086op only obo:TXPO_0000854c
obo:TXPO_0000774op only obo:TXPO_0003359c

hyperfunction of increasing the amount of drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001825
Super-classes obo:TXPO_0001724c
Restrictions obo:TXPO_0001502op some obo:TXPO_0001635c
Sub-classes obo:TXPO_0001827c

receiving abnormal protein signal by PERK [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001826
Super-classes obo:TXPO_0002741c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002412c
obo:TXPO_0000012op some obo:TXPO_0000463c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002994c

hyperfunction of increasing the amount of drug [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001827
Super-classes obo:TXPO_0001825c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000716op some obo:TXPO_0001637c
obo:TXPO_0000069op some obo:TXPO_0001665c
Sub-classes obo:TXPO_0001840c

receptor molecule [signal transduction system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001828
Super-classes obo:TXPO_0001821c
Restrictions obo:RO_0000087op some obo:TXPO_0002463c
obo:RO_0000056op some obo:TXPO_0002174c

hypofunction of ceramide degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001829
Super-classes obo:TXPO_0002006c
Restrictions obo:TXPO_0000716op some obo:GO_0046514c
Sub-classes obo:TXPO_0003445c

decreasing production quantity of proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001830
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0002799c
obo:TXPO_0000397c

phosphatidylinositol accumulation in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001831
Super-classes obo:TXPO_0001697c
Sub-classes obo:TXPO_0003374c

hyperfunction of decreasingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001832
Super-classes obo:TXPO_0000435c
Sub-classes obo:TXPO_0001834c

signaling molecule [signal transduction system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001833
Super-classes obo:TXPO_0001821c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0001896op some obo:GO_0023052c

hyperfunction of decreasing the amount of drugsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001834
Super-classes obo:TXPO_0001832c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001639c
Sub-classes obo:TXPO_0003859c

Dissociation of PERK:BIP Heterodimer [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001835
Description

PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.
Super-classes obo:TXPO_0002213c
Restrictions obo:RO_0002233op some obo:TXPO_0002109c
obo:TXPO_0000069op some obo:TXPO_0002867c
obo:RO_0002234op some obo:TXPO_0002864c
obo:RO_0002234op some obo:TXPO_0003157c

hyperfunction of decreasing the amount of drug [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001836
Super-classes obo:TXPO_0003859c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001647c
obo:TXPO_0000069op some obo:TXPO_0001843c
obo:TXPO_0000774op only obo:TXPO_0001432c

receiving signal in PERK signal transduction pathway [PERK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001837
Super-classes obo:TXPO_0002174c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000454c
Sub-classes obo:TXPO_0002749c
obo:TXPO_0002741c

hyperfunction of hepatocyte proliferation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001838
Super-classes obo:TXPO_0002321c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

Dissociation of PERK:BIP Heterodimer [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001839
Description

PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.
Super-classes obo:TXPO_0002213c
Restrictions obo:RO_0002234op some obo:TXPO_0003157c
obo:TXPO_0000069op some obo:TXPO_0002866c
obo:RO_0002234op some obo:TXPO_0002845c

hyperfunction of increasing the amount of phenobarbital [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001840
Super-classes obo:TXPO_0001827c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003860c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000716op some obo:TXPO_0001637c
Sub-classes obo:TXPO_0002311c
obo:TXPO_0003868c

PERK - signal sensor (canonical)[Perk signalling system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001841
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000087op some obo:TXPO_0000882c
obo:TXPO_0001896op some obo:TXPO_0001837c
Sub-classes obo:TXPO_0002994c
obo:TXPO_0002625c
obo:TXPO_0002730c
obo:TXPO_0002993c
obo:TXPO_0002848c
obo:TXPO_0000301c

increasing the amount of phenobarbital [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001842
Super-classes obo:TXPO_0001637c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

drug metabolism imbalance[Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001843
Super-classes obo:TXPO_0001665c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0001848c

lipid accumulation in hepatocyte [Phospholipidosis(severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001844
Super-classes obo:TXPO_0001716c
obo:TXPO_0001645c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0001698c

S1P inactivation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001845
Super-classes obo:TXPO_0001716c
obo:TXPO_0001706c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:RO_0002234op some obo:TXPO_0001609c
obo:TXPO_0001868op some obo:TXPO_0001586c
obo:TXPO_0000069op some obo:TXPO_0000928c

malfunctioning of mitochondrial ATP synthesis coupled electron transporc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001846
Super-classes obo:TXPO_0000434c
Sub-classes obo:TXPO_0001747c
obo:TXPO_0000869c
obo:TXPO_0001197c

changing balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001847
Super-classes obo:TXPO_0000261c
Sub-classes obo:TXPO_0000567c
obo:TXPO_0001263c
obo:TXPO_0003551c
obo:TXPO_0000957c
obo:TXPO_0001161c
obo:TXPO_0001658c
obo:TXPO_0000682c
obo:TXPO_0001162c
obo:TXPO_0003544c
obo:TXPO_0002132c

chemical compound accumulation in liver [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001848
Super-classes obo:TXPO_0002068c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

phospholipidosis dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001849
Super-classes obo:TXPO_0001133c
Sub-classes obo:TXPO_0003225c
obo:TXPO_0000318c
obo:TXPO_0004147c
obo:TXPO_0000081c
obo:TXPO_0003228c
obo:TXPO_0003543c
obo:TXPO_0000319c
obo:TXPO_0003570c
obo:TXPO_0003226c
obo:TXPO_0001857c
obo:TXPO_0001560c
obo:TXPO_0001425c
obo:TXPO_0001566c
obo:TXPO_0003599c
obo:TXPO_0003227c
obo:TXPO_0003349c
obo:TXPO_0000499c
obo:TXPO_0003345c
obo:TXPO_0000313c
obo:TXPO_0001609c
obo:TXPO_0000500c
obo:TXPO_0000317c
obo:TXPO_0002296c

hepatic fibrosis [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001850
Super-classes obo:TXPO_0000816c
obo:TXPO_0001716c
Restrictions obo:BFO_0000051op some obo:TXPO_0001853c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0002264c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:RO_0000057op only obo:TXPO_0002251c
obo:RO_0000057op some obo:TXPO_0003788c

making existence of xenobioticsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001851
Super-classes obo:TXPO_0000968c
Sub-classes obo:TXPO_0000651c
obo:TXPO_0003854c

PERK - signaling factor (canonical)[Perk signalling system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001852
Super-classes obo:TXPO_0000878c
Restrictions obo:TXPO_0001896op some obo:TXPO_0000454c
obo:RO_0000087op some obo:TXPO_0001898c
Sub-classes obo:TXPO_0002119c

TGF beta receptor signaling (primitive) [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001853
Super-classes obo:TXPO_0001854c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op only obo:TXPO_0001158c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0003890c

TGF beta receptor signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001854
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0007179c
Sub-classes obo:TXPO_0001853c
obo:TXPO_0004588c

decreasing mitochondrial membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001855
Super-classes obo:TXPO_0001995c
Restrictions obo:BFO_0000066op only obo:GO_0031966c
Sub-classes obo:TXPO_0001993c
obo:TXPO_0002233c
obo:TXPO_0000982c
obo:TXPO_0001085c

heme biosynthetic process [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001856
Super-classes obo:TXPO_0001720c
obo:TXPO_0004004c
Restrictions obo:RO_0000057op some obo:TXPO_0004003c
obo:TXPO_0000774op only obo:TXPO_0001127c
obo:RO_0000057op some obo:TXPO_0001774c
obo:RO_0000057op some obo:TXPO_0003915c
obo:TXPO_0000069op some obo:TXPO_0003510c

LPA [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001857
Super-classes obo:TXPO_0001849c
obo:CHEBI_132742c
Restrictions obo:RO_0000056op some obo:TXPO_0001497c
obo:RO_0000087op some obo:TXPO_0002401c
obo:RO_0000087op some obo:TXPO_0002271c
obo:RO_0000087op some obo:TXPO_0003686c

hypofunction of PPARa regulated gene expression [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001858
Super-classes obo:TXPO_0001720c
obo:TXPO_0001860c
Restrictions obo:RO_0000057op some obo:TXPO_0001961c
obo:RO_0000057op some obo:TXPO_0003915c
obo:RO_0000057op some obo:TXPO_0001774c
obo:RO_0000057op some obo:TXPO_0001808c
obo:RO_0000057op some obo:TXPO_0001884c

CYP4A11(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001859
Super-classes obo:TXPO_0003836c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001579c
Sub-classes obo:TXPO_0002553c
obo:TXPO_0003881c

hypofunction of PPARa regulated gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001860
Super-classes obo:TXPO_0002356c
Sub-classes obo:TXPO_0001858c

changing activity of target molecule by PERK [PERK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001861
Super-classes obo:TXPO_0000020c
Sub-classes obo:TXPO_0000696c
obo:TXPO_0002736c

release of DNA from mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001863
Super-classes obo:TXPO_0002588c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:RO_0002234op only efo:EFO_0008480c
Sub-classes obo:TXPO_0004259c
obo:TXPO_0001864c
obo:TXPO_0004309c

release of DNA from mitochondria [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001864
Super-classes obo:TXPO_0001720c
obo:TXPO_0001863c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001744c
obo:RO_0002234op only efo:EFO_0008480c
obo:RO_0000057op some obo:TXPO_0001102c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:BFO_0000066op some obo:GO_0005739c

protein kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001865
Super-classes obo:TXPO_0001515c
Sub-classes obo:TXPO_0001966c
obo:TXPO_0002002c
obo:TXPO_0002292c

inhibitor role of BSEP bile acid transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001866
Super-classes obo:TXPO_0000082c
Restrictions obo:RO_0002599op some obo:GO_0015721c

negative regulator role of transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001867
Super-classes obo:TXPO_0000036c
Restrictions obo:RO_0002599op some obo:GO_0006810c

organic anion import into hepatocyte vascular side (sinusoidal side) membrane [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001869
Description

The sodium-independent portion of bile salt uptake is mediated by OATPs
Super-classes obo:TXPO_0001783c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000272c

gene expression by CHOP (DDIT3, GADD153)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001874
Super-classes obo:TXPO_0000375c
Sub-classes obo:TXPO_0002767c

IL-1B (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001875
Super-classes obo:TXPO_0003516c
obo:TXPO_1000200c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

NLRP3 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001876
Super-classes obo:TXPO_0003516c
obo:TXPO_0001877c

NLRP3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001877
Super-classes obo:CHEBI_25367c
obo:TXPO_0000871c
Sub-classes obo:TXPO_0001876c
obo:TXPO_0004925c

IL-1beta production [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001878
Super-classes obo:GO_0032611c
obo:TXPO_0001720c
Restrictions obo:BFO_0000066op some obo:CL_0000091c
obo:TXPO_0001868op some obo:TXPO_0001079c
obo:TXPO_0000069op some obo:TXPO_0003620c
obo:BFO_0000051op some obo:TXPO_0001065c
obo:RO_0002234op some obo:TXPO_0001875c

increasing volume of mitochondria [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001879
Super-classes obo:TXPO_0000143c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004345c
obo:RO_0002234op some (obo:GO_0005739c and ub744bL66673C17c)
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002233op some obo:GO_0005739c

generating energyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001880
Super-classes obo:TXPO_0000381c
Restrictions obo:RO_0002234op some owl:Thingc

findings attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001881
Super-classes obo:TXPO_0000305c

electrophiles formation [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001882
Description

A number of xenobiotics exert a toxic effect theough their metabolites. Electrophiles are molecules that contain an electron-deficient atom with a partial or full positive charge that can react by sharing electron pairs with electron rich atoms in nucleophiles. Electrophilic toxicants generally are detoxificated by conjugation of with the nucleophile, glutathione. This reaction can be facilitated by glutathione S-trasferases.
Super-classes obo:TXPO_0001720c
obo:TXPO_0000212c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0003512c
obo:RO_0002234op some obo:TXPO_0003630c
obo:RO_0002233op some obo:TXPO_0003748c

PYCARD (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001883
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001886c

FGF21 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001884
Super-classes obo:TXPO_1000145c
obo:TXPO_0003516c
Restrictions obo:TXPO_0002260op some obo:IMR_0100571c
obo:TXPO_0000819op some obo:OGG_3000026291c

rifampicin [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001885
Description

Rifampicin, bosentan, and troglitazone directly inhibit bile salt export pump (BSEP).
Super-classes obo:TXPO_0000749c
obo:CHEBI_28077c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

PYCARD (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001886
Super-classes obo:TXPO_0003516c
obo:TXPO_0001883c

CYP3A4 (human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001888
Super-classes obo:TXPO_1000082c
obo:TXPO_0001786c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000756op some ncicp:C15958c
Sub-classes obo:TXPO_0001891c

cytochrome P450 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001889
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0001558c and ub744bL66813C17c)
Sub-classes obo:TXPO_0001890c

cytochrome P450 inactivation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001890
Super-classes obo:TXPO_0001889c
obo:TXPO_0001720c
Restrictions obo:RO_0002233op some obo:TXPO_0001888c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0002234op some obo:TXPO_0001891c

CYP3A4 -inactitication state (human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001891
Super-classes obo:TXPO_0001888c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000756op some ncicp:C15958c

negative regulation of bile acid and bile salts export from the hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001892
Super-classes obo:TXPO_0002682c
Restrictions obo:RO_0002212op some obo:TXPO_0002683c
Sub-classes obo:TXPO_0002733c
obo:TXPO_0002681c

protein unfolding [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001894
Super-classes obo:GO_0043335c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0001115c
obo:BFO_0000066op some obo:GO_0005783c

fenofibrate [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001895
Super-classes obo:TXPO_0000121c
obo:CHEBI_5001c

clofibrate [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001897
Description

Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia. Clofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury.
Super-classes obo:CHEBI_3750c
obo:TXPO_0000121c

signal transducerc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001898
Super-classes obo:CHEBI_33280c

eIF2a phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001899
Super-classes obo:GO_0016310c
Sub-classes obo:TXPO_0000697c
obo:TXPO_0000549c

anion channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001900
Description

related molecular function GO:0005253
Super-classes obo:TXPO_0000328c
Sub-classes obo:TXPO_0001998c

TNF alpha (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001901
Super-classes obo:TXPO_1000374c
obo:TXPO_0003516c

gene regulation pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001902
Super-classes obo:NCIT_C54214c
Restrictions obo:BFO_0000051op some obo:GO_0010468c
obo:BFO_0000051op some obo:TXPO_0000389c
obo:TXPO_0002525op some obo:TXPO_0000027c
obo:BFO_0000051op some obo:GO_0010467c
Sub-classes obo:GO_0072331c
obo:TXPO_0002754c
obo:TXPO_0002486c
obo:TXPO_0002483c
obo:TXPO_0002774c
obo:TXPO_0002520c
obo:TXPO_0002485c
obo:TXPO_0003145c

RSAD2(predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001903
Super-classes obo:TXPO_0001135c
obo:TXPO_0003835c
Restrictions obo:TXPO_0000819op some obo:OGG_3000091543c
obo:RO_0000086op some obo:TXPO_0000657c

ATF6 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001904
Super-classes obo:TXPO_0000124c
Sub-classes obo:TXPO_0000710c

ATF6 activation [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001905
Super-classes obo:TXPO_0000710c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0002901c
obo:BFO_0000051op some obo:TXPO_0002467c
obo:BFO_0000051op some obo:TXPO_0002466c

acumulation of bile pigment in bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001906
Super-classes obo:TXPO_0000083c
Restrictions obo:BFO_0000066op some obo:UBERON_0001283c
Sub-classes obo:TXPO_0002678c

ATF4 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001907
Super-classes obo:TXPO_0000871c
obo:TXPO_1000012c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0002260op some obo:IMR_0000825c
obo:TXPO_0000819op some obo:OGG_3000000468c
Sub-classes obo:TXPO_0002559c
obo:TXPO_0002970c
obo:TXPO_0002969c
obo:TXPO_0003055c
obo:TXPO_0002965c
obo:TXPO_0002558c
obo:TXPO_0002560c

negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001908
Super-classes obo:TXPO_0003414c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004933c
obo:TXPO_0000774op only obo:TXPO_0001964c
obo:TXPO_0001868op some obo:TXPO_0003227c
obo:TXPO_0000012op some obo:TXPO_0002572c
obo:TXPO_0000012op some obo:TXPO_0003578c
obo:TXPO_0001868op some obo:TXPO_0003228c
obo:TXPO_0001868op some obo:TXPO_0000319c

negative regulator role of translational initiationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001909
Description

related process

GO:0036495 negative regulation of translation initiation in response to endoplasmic reticulum stress

GO:0010998: regulation of translational initiation by eIF2 alpha phosphorylation (Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.)

GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress

inverse of GO:0036497 eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
Super-classes obo:TXPO_0002557c

hypofunction of biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001910
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0009058c
Sub-classes obo:TXPO_0002195c
obo:TXPO_0005053c
obo:TXPO_0004795c
obo:TXPO_0001722c
obo:TXPO_0001958c
obo:TXPO_0001352c
obo:TXPO_0001331c
obo:TXPO_0003920c

hypofunction of transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001911
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000442c
Sub-classes obo:TXPO_0003483c
obo:TXPO_0000085c
obo:TXPO_0000714c
obo:TXPO_0002048c
obo:TXPO_0000495c
obo:TXPO_0001261c
obo:TXPO_0003269c
obo:TXPO_0000045c
obo:TXPO_0001769c
obo:TXPO_0004145c
obo:TXPO_0004009c

increasing blood glucose levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001912
Super-classes obo:TXPO_0000352c
Restrictions obo:TXPO_0000531op some obo:HP_0003074c
Sub-classes obo:TXPO_0001245c
obo:TXPO_0003290c
obo:TXPO_0005034c

decresing pressurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001913
Super-classes obo:TXPO_0000475c
Restrictions obo:RO_0002234op some (obo:BFO_0000001c and ub744bL67120C17c)
obo:TXPO_0000531op some obo:PATO_0001575c
Sub-classes obo:TXPO_0003307c

increasing BUN concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001914
Super-classes obo:TXPO_0000352c

glutathione depletion dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001915
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
Sub-classes obo:TXPO_0002045c
obo:TXPO_0001927c
obo:TXPO_0002285c
obo:TXPO_0001921c
obo:TXPO_0001916c

glutathione depletion dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001916
Super-classes obo:TXPO_0001915c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
obo:TXPO_0000756op some ncicp:C15958c
Sub-classes obo:TXPO_0000654c
obo:TXPO_0000661c
obo:TXPO_0001918c
obo:TXPO_0000894c
obo:TXPO_0001919c
obo:TXPO_0001917c
obo:TXPO_0000663c

G6PD (predicted)(human)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001917
Description

predicted gene by Support Vector Machine (SVM) using human primary hepatocyte
Super-classes obo:TXPO_0001916c
obo:TXPO_1000158c
Restrictions obo:RO_0000087op some obo:TXPO_0002402c
obo:TXPO_0000819op some obo:OGG_3000002539c
obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000756op some ncicp:C15958c

BLHA15 (predicted)(human)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001918
Description

predicted gene by Support Vector Machine (SVM) using human primary hepatocyte
Super-classes obo:TXPO_1000045c
obo:TXPO_0001916c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000168620c

HISTH1H2BG (predicted)(human)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001919
Description

predicted gene by Support Vector Machine (SVM) using human primary hepatocyte
Super-classes obo:TXPO_1000194c
obo:TXPO_0001916c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008339c
obo:RO_0000086op some obo:TXPO_0000657c

electrophiles formation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001920
Description

A number of xenobiotics exert a toxic effect theough their metabolites. Electrophiles are molecules that contain an electron-deficient atom with a partial or full positive charge that can react by sharing electron pairs with electron rich atoms in nucleophiles. Electrophilic toxicants generally are detoxificated by conjugation of with the nucleophile, glutathione. This reaction can be facilitated by glutathione S-trasferases.
Super-classes obo:TXPO_0000889c
obo:TXPO_0000212c
Restrictions obo:TXPO_0001868op some obo:TXPO_0003805c
obo:TXPO_0000069op some obo:TXPO_0002407c
obo:TXPO_0000069op some obo:TXPO_0001185c
obo:RO_0002233op some obo:TXPO_0001922c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0001868op some obo:TXPO_0003171c
obo:TXPO_0000069op some obo:TXPO_0002431c
obo:RO_0002234op some obo:TXPO_0000974c
obo:TXPO_0001868op some obo:TXPO_0003170c

glutathione depletion dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001921
Super-classes obo:TXPO_0001915c
Sub-classes obo:TXPO_0000974c
obo:TXPO_0001941c
obo:TXPO_0001922c
obo:TXPO_0002452c
obo:TXPO_0002065c
obo:TXPO_0001942c
obo:TXPO_0001924c

Acetaminophen [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001922
Super-classes obo:TXPO_0001921c
obo:CHEBI_46195c

glutathione conjugation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001923
Super-classes obo:TXPO_0003991c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

phorone [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001924
Super-classes obo:CHEBI_35572c
obo:TXPO_0001921c

hyperfunction of glutathione conjugation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001925
Super-classes obo:TXPO_0001228c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002613c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0002711c

negative regulation of DNA repairc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001926
Super-classes obo:TXPO_0000965c
obo:GO_0043066c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0001939c
obo:TXPO_0000069op some obo:TXPO_0002320c

glutathione depletion dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001927
Super-classes obo:TXPO_0001915c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0001949c
obo:TXPO_0001932c
obo:TXPO_0001943c
obo:TXPO_0001950c
obo:TXPO_0001329c
obo:TXPO_0001930c
obo:TXPO_0001936c
obo:TXPO_0001935c
obo:TXPO_0001945c
obo:TXPO_0001954c
obo:TXPO_0001952c
obo:TXPO_0001938c
obo:TXPO_0001948c
obo:TXPO_0001940c
obo:TXPO_0001953c
obo:TXPO_0001928c
obo:TXPO_0001934c

Srxn1 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001928
Super-classes obo:TXPO_1000365c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

GSS (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001929
Description

ATP dependent.
Super-classes obo:TXPO_0002045c
obo:TXPO_0001931c
Restrictions obo:RO_0000087op some obo:TXPO_0001937c

Txnrd1 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001930
Super-classes obo:TXPO_0001927c
obo:TXPO_1000389c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

GSS (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001931
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002937c
Sub-classes obo:TXPO_0001929c

Mdm2 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001932
Super-classes obo:TXPO_0001927c
obo:IMR_0100660c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0002399c

hyperfunction of glutathione synthetic gene expression [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001933
Super-classes obo:TXPO_0001378c
obo:TXPO_0000889c
Restrictions obo:BFO_0000051op some obo:TXPO_0002404c
obo:BFO_0000051op some obo:TXPO_0002216c
obo:BFO_0000051op some obo:TXPO_0002254c
obo:TXPO_0000069op some obo:TXPO_0001194c
obo:BFO_0000051op some obo:TXPO_0000904c
obo:TXPO_0000774op only obo:TXPO_0000501c

Akr7a3 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001934
Super-classes obo:TXPO_1000033c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Osgin1 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001935
Super-classes obo:TXPO_0001927c
obo:TXPO_1000272c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Me1 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001936
Super-classes obo:TXPO_1000244c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

glutathione synthasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001937
Super-classes obo:TXPO_0000171c

Aldh1a1 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001938
Super-classes obo:TXPO_0001927c
obo:TXPO_1000035c
Restrictions obo:RO_0000087op some obo:TXPO_0002396c
obo:TXPO_0000756op some obo:TXPO_0000489c

DDB2 -inactivation (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001939
Super-classes obo:TXPO_0001019c
Restrictions obo:TXPO_0001733op some obo:PATO_0002355c
obo:RO_0000087op some obo:TXPO_0001561c

Gsta3 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001940
Super-classes obo:TXPO_0001927c
obo:TXPO_1000179c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

diethyl malate [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001941
Super-classes obo:TXPO_0001921c
obo:CHEBI_68508c
Restrictions obo:RO_0000087op some obo:BFO_0000023c

BSO [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001942
Super-classes obo:NCIT_C1029c
obo:TXPO_0001921c

Gclc (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001943
Super-classes obo:TXPO_0001927c
obo:TXPO_1000163c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0002394c

negative regulation of glutathione biosyntheric process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001944
Super-classes obo:TXPO_0000889c
obo:TXPO_0001946c
Restrictions obo:BFO_0000051op some obo:TXPO_0001955c
obo:RO_0000057op some obo:TXPO_0001942c
obo:TXPO_0000069op some obo:TXPO_0003288c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0002212op some obo:GO_0006750c

Gadd45a (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001945
Super-classes obo:TXPO_1000174c
obo:TXPO_0001927c
Restrictions obo:TXPO_0002260op some obo:IMR_0000559c
obo:TXPO_0000756op some obo:TXPO_0000489c

negative regulation of glutathione biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001946
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006750c
Sub-classes obo:TXPO_0001944c

GSTA1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001947
Super-classes obo:TXPO_0002089c

Jun (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001948
Super-classes obo:IMR_0000416c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Cyp2b1 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001949
Super-classes obo:TXPO_0001927c
obo:TXPO_1000101c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Pdk4 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001950
Super-classes obo:TXPO_1000298c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

GCLC - inactivated state (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001951
Super-classes obo:TXPO_0000193c
Restrictions obo:RO_0000087op some obo:TXPO_0002394c
obo:RO_0000086op some obo:PATO_0002355c

Gpx2 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001952
Super-classes obo:TXPO_0001927c
obo:TXPO_1000178c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Trib3 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001953
Super-classes obo:TXPO_1000378c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Gstm3 (rat)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001954
Super-classes obo:TXPO_1000180c
obo:TXPO_0001927c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

GCLC inactivation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001955
Super-classes obo:TXPO_0002000c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001944c
obo:RO_0000057op some obo:TXPO_0001951c
obo:TXPO_0001868op some obo:TXPO_0001942c

changing protein structure [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001956
Super-classes obo:TXPO_0001717c
obo:TXPO_0000660c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0001965c

hypofunction of forming disulfide bondc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001957
Super-classes obo:TXPO_0000436c
Sub-classes obo:TXPO_0001959c

hypofunction of protein synthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001958
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000382c
obo:BFO_0000051op some obo:TXPO_0001957c
Sub-classes obo:TXPO_0003506c

hypofunction of forming disulfide bond [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001959
Super-classes obo:TXPO_0001717c
obo:TXPO_0001957c
Restrictions obo:RO_0000057op some obo:TXPO_0000790c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000734c

HSP90B1 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001960
Super-classes obo:TXPO_1000171c
obo:TXPO_0000871c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
obo:TXPO_0000756op some obo:TXPO_0000795c
obo:TXPO_0000819op some obo:OGG_3000007184c
Sub-classes obo:TXPO_0003034c

CPT1 (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001961
Super-classes obo:TXPO_1000097c
obo:TXPO_0003516c
Restrictions obo:RO_0000087op some obo:TXPO_0001967c
obo:TXPO_0000043op some obo:GO_0005739c
obo:RO_0000087op some obo:TXPO_0001969c
Sub-classes obo:TXPO_0001974c

tunicamycin-protein glycosylation inhibitor [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001962
Super-classes obo:TXPO_0003012c
obo:CHEBI_29699c
Restrictions obo:RO_0000087op some obo:TXPO_0002184c
obo:TXPO_0000774op only obo:TXPO_0002528c

hypofunction of protein glycosylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001963
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0006486c

phospholipidosis (latent)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001964
Super-classes obo:TXPO_0003382c
Restrictions obo:BFO_0000051op some obo:TXPO_0002522c
obo:BFO_0000051op some obo:TXPO_0003678c
obo:BFO_0000051op some obo:TXPO_0004933c
obo:BFO_0000051op some obo:TXPO_0005189c
obo:TXPO_0000004op only obo:TXPO_0002293c
obo:BFO_0000051op some obo:TXPO_0005059c
obo:BFO_0000051op some obo:TXPO_0002273c
obo:BFO_0000051op some obo:TXPO_0002293c

negative regulation of glycosylation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001965
Super-classes obo:TXPO_0001717c
obo:TXPO_0001516c
Restrictions obo:TXPO_0001868op only obo:TXPO_0001962c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002161c

protein serine/threonine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001966
Super-classes obo:TXPO_0001865c
Sub-classes obo:TXPO_0002154c

carnitine palmitoyltransferasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001967
Super-classes obo:TXPO_0001385c

XBP1 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001968
Super-classes obo:TXPO_0000871c
obo:TXPO_1000405c
Restrictions obo:RO_0000087op some obo:TXPO_0002196c
Sub-classes obo:TXPO_0003066c
obo:TXPO_0002605c
obo:TXPO_0003050c
obo:TXPO_0002923c

mitochondrial fatty acid βbeta-oxidation rate-limiting enzyme rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001969
Super-classes obo:TXPO_0003230c

CPT1 inactivation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001970
Super-classes obo:TXPO_0001720c
obo:TXPO_0001971c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0000901c
obo:RO_0000057op some obo:TXPO_0001974c
obo:TXPO_0001868op some obo:TXPO_0000788c

CPT1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001971
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000097c and ub744bL67944C17c)
Sub-classes obo:TXPO_0001970c

negative regulation of mitochondrial beta oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001972
Super-classes obo:TXPO_0000115c
Sub-classes obo:TXPO_0001973c

negative regulation of mitochondrial beta oxidation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001973
Super-classes obo:TXPO_0001720c
obo:TXPO_0001972c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000787c
obo:TXPO_0001868op some obo:TXPO_0000788c
obo:TXPO_0000069op some obo:TXPO_0000901c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0001868op some obo:TXPO_0000880c
obo:BFO_0000051op some obo:TXPO_0001970c
obo:BFO_0000066op some obo:GO_0005739c

CPT1 -inactivation state(canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001974
Super-classes obo:TXPO_0001961c
Restrictions obo:RO_0000087op some obo:TXPO_0001967c
obo:TXPO_0000043op some obo:GO_0005739c
obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000087op some obo:TXPO_0001969c

tamoxifen -fatty acid oxidation inhibitor [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001975
Super-classes obo:TXPO_0000787c
Restrictions obo:RO_0000087op some obo:CHEBI_133190c

valproic acid - fatty acid oxidation inhibitor [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001976
Super-classes obo:TXPO_0000788c
Restrictions obo:RO_0000087op some obo:CHEBI_133190c

accumulation of abnormal proteins in ER [ER stress (mild) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001977
Super-classes obo:TXPO_0000194c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002460c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0000403c

feature gene rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001978
Super-classes obo:TXPO_0001225c

enterohepatic circulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001979
Description

Bile salts (>90%) are absorbed along the small intestine and transported back by the portal blood to the liver. They are taken up into hepatocytes and re-secreted into the canaliculi. This round trip of bile salts between the intestine and the liver is termed enterohepatic circulation.
Super-classes obo:TXPO_0000261c
Sub-classes obo:TXPO_0002675c

DTT [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001980
Super-classes obo:CHEBI_18320c
obo:TXPO_0003012c
Restrictions obo:RO_0000087op some obo:CHEBI_64909c

Ccl4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001981
Super-classes obo:CHEBI_27385c
obo:TXPO_0003012c
Restrictions obo:RO_0000087op some obo:CHEBI_64909c

meloxicam [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001982
Super-classes obo:TXPO_0003012c
obo:CHEBI_6741c
Restrictions obo:RO_0000087op some obo:CHEBI_64909c
Sub-classes obo:TXPO_0000090c

amiodarone - fatty acid oxidation inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001983
Super-classes obo:TXPO_0000880c
Restrictions obo:RO_0000087op some obo:CHEBI_133190c

changing statec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001984
Super-classes obo:TXPO_0000392c
Sub-classes obo:TXPO_0005011c
obo:GO_0050896c
obo:GO_1902292c
obo:TXPO_0004947c

mutationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001985
Super-classes obo:TXPO_0000392c
Sub-classes obo:TXPO_0001444c
obo:TXPO_0004966c
obo:TXPO_0003635c
obo:TXPO_0001167c
obo:TXPO_0004890c
obo:TXPO_0004902c

mitochondrial damage [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001986
Description

under construction
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0001989c
obo:BFO_0000051op some obo:TXPO_0004253c
obo:BFO_0000051op some obo:TXPO_0002005c
obo:BFO_0000051op some obo:TXPO_0004346c
obo:BFO_0000051op some obo:TXPO_0004436c
obo:BFO_0000051op some obo:TXPO_0004262c
obo:BFO_0000051op some obo:TXPO_0004135c
obo:BFO_0000051op some obo:TXPO_0004255c
obo:BFO_0000051op some obo:TXPO_0004274c
obo:BFO_0000051op some obo:TXPO_0004442c
obo:BFO_0000051op some obo:TXPO_0004247c
obo:BFO_0000051op some obo:TXPO_0004344c
obo:BFO_0000051op some obo:TXPO_0001997c
obo:BFO_0000051op some obo:TXPO_0004380c
obo:BFO_0000051op some obo:TXPO_0003568c
obo:BFO_0000051op some obo:TXPO_0002038c
obo:BFO_0000051op some obo:TXPO_0004225c
obo:BFO_0000051op some obo:TXPO_0004382c
obo:BFO_0000051op some obo:TXPO_0004269c
obo:BFO_0000051op some obo:TXPO_0002010c
obo:BFO_0000051op some obo:TXPO_0004830c
obo:BFO_0000051op some obo:TXPO_0004974c
obo:BFO_0000051op some obo:TXPO_0004393c
obo:BFO_0000051op some obo:TXPO_0001990c
obo:BFO_0000051op some obo:TXPO_0004351c
obo:BFO_0000051op some obo:TXPO_0004761c
obo:BFO_0000051op some obo:TXPO_0004281c
obo:BFO_0000051op some obo:TXPO_0004906c
obo:BFO_0000051op some obo:TXPO_0004990c
obo:BFO_0000051op some obo:TXPO_0004245c
obo:BFO_0000051op some obo:TXPO_0004383c
obo:BFO_0000051op some obo:TXPO_0005057c
obo:BFO_0000051op some obo:TXPO_0004718c
obo:BFO_0000051op some obo:TXPO_0001988c
obo:BFO_0000051op some obo:TXPO_0004937c
obo:BFO_0000051op some obo:TXPO_0004723c
obo:BFO_0000051op some obo:TXPO_0005044c
obo:BFO_0000051op some obo:TXPO_0004109c
obo:BFO_0000051op some obo:TXPO_0004742c
obo:BFO_0000051op some obo:TXPO_0004350c
obo:BFO_0000051op some obo:TXPO_0004376c
obo:BFO_0000051op some obo:TXPO_0004266c
obo:BFO_0000051op some obo:TXPO_0004251c
obo:BFO_0000051op some obo:TXPO_0004270c
obo:BFO_0000051op some obo:TXPO_0004366c
obo:BFO_0000051op some obo:TXPO_0004340c
obo:BFO_0000051op some obo:TXPO_0004241c
obo:BFO_0000051op some obo:TXPO_0004295c
obo:BFO_0000051op some obo:TXPO_0005034c
obo:BFO_0000051op some obo:TXPO_0004272c
obo:BFO_0000051op some obo:TXPO_0003569c
obo:BFO_0000051op some obo:TXPO_0002230c
obo:BFO_0000051op some obo:TXPO_0004267c
obo:BFO_0000051op some obo:TXPO_0001991c
obo:BFO_0000051op some obo:TXPO_0004797c
obo:BFO_0000051op some obo:TXPO_0004444c
obo:BFO_0000051op some obo:TXPO_0004390c
obo:BFO_0000051op some obo:TXPO_0001879c
obo:BFO_0000051op some obo:TXPO_0004119c
obo:BFO_0000051op some obo:TXPO_0004956c
obo:BFO_0000051op some obo:TXPO_0004445c
obo:BFO_0000051op some obo:TXPO_0004347c
obo:BFO_0000051op some obo:TXPO_0004927c
obo:BFO_0000051op some obo:TXPO_0004273c
obo:BFO_0000051op some obo:TXPO_0004416c
obo:BFO_0000051op some obo:TXPO_0004258c
obo:BFO_0000051op some obo:TXPO_0004349c
obo:BFO_0000051op some obo:TXPO_0004271c
obo:BFO_0000051op some obo:TXPO_0002004c
obo:BFO_0000051op some obo:TXPO_0004371c
obo:BFO_0000051op some obo:TXPO_0004928c
obo:BFO_0000051op some obo:TXPO_0004265c
obo:BFO_0000051op some obo:TXPO_0004254c
obo:BFO_0000051op some obo:TXPO_0004125c
obo:BFO_0000051op some obo:TXPO_0004268c
obo:BFO_0000051op some obo:TXPO_0001992c
obo:BFO_0000051op some obo:TXPO_0004981c
obo:BFO_0000051op some obo:TXPO_0004257c
obo:BFO_0000051op some obo:TXPO_0004717c
obo:BFO_0000051op some obo:TXPO_0004360c
obo:BFO_0000051op some obo:TXPO_0005118c
obo:BFO_0000051op some obo:TXPO_0004955c
obo:BFO_0000051op some obo:TXPO_0004250c
obo:BFO_0000051op some obo:TXPO_0004368c
obo:BFO_0000051op some obo:TXPO_0004939c
obo:BFO_0000051op some obo:TXPO_0004124c
obo:BFO_0000051op some obo:TXPO_0004263c
obo:BFO_0000051op some obo:TXPO_0004246c
obo:BFO_0000051op some obo:TXPO_0001999c
obo:BFO_0000051op some obo:TXPO_0004378c
obo:BFO_0000051op some obo:TXPO_0004278c
obo:BFO_0000051op some obo:TXPO_0004976c
obo:BFO_0000051op some obo:TXPO_0004964c
obo:BFO_0000051op some obo:TXPO_0004243c
obo:BFO_0000051op some obo:TXPO_0004260c
obo:BFO_0000051op some obo:TXPO_0004941c
obo:BFO_0000051op some obo:TXPO_0004324c
obo:BFO_0000051op some obo:TXPO_0004833c
obo:BFO_0000051op some obo:TXPO_0004561c
obo:BFO_0000051op some obo:TXPO_0004325c
obo:BFO_0000051op some obo:TXPO_0004261c
obo:BFO_0000051op some obo:TXPO_0004259c
obo:BFO_0000051op some obo:TXPO_0004741c
obo:BFO_0000051op some obo:TXPO_0004549c
obo:BFO_0000051op some obo:TXPO_0005055c
obo:BFO_0000051op some obo:TXPO_0004367c
obo:BFO_0000051op some obo:TXPO_0004461c
obo:BFO_0000051op some obo:TXPO_0004373c
obo:BFO_0000051op some obo:TXPO_0004379c
obo:BFO_0000051op some obo:TXPO_0002040c
obo:BFO_0000051op some obo:TXPO_0004348c
obo:BFO_0000051op some obo:TXPO_0004343c
obo:BFO_0000051op some obo:TXPO_0005112c
obo:BFO_0000051op some obo:TXPO_0004359c
obo:BFO_0000051op some obo:TXPO_0004252c
obo:BFO_0000051op some obo:TXPO_0004242c
obo:BFO_0000051op some obo:TXPO_0004307c
obo:TXPO_0000004op some obo:TXPO_0001993c
obo:BFO_0000051op some obo:TXPO_0004936c
obo:BFO_0000051op some obo:TXPO_0004370c
obo:BFO_0000051op some obo:TXPO_0004987c
obo:BFO_0000051op some obo:TXPO_0004443c
obo:BFO_0000051op some obo:TXPO_0004120c
obo:BFO_0000051op some obo:TXPO_0004960c
obo:BFO_0000051op some obo:TXPO_0005106c
obo:BFO_0000051op some obo:TXPO_0004369c
obo:BFO_0000051op some obo:TXPO_0005009c
obo:BFO_0000051op some obo:TXPO_0004440c
obo:BFO_0000051op some obo:TXPO_0004372c
obo:BFO_0000051op some obo:TXPO_0004559c
obo:BFO_0000051op some obo:TXPO_0004126c
obo:BFO_0000051op some obo:TXPO_0000933c
obo:BFO_0000051op some obo:TXPO_0005115c
obo:BFO_0000051op some obo:TXPO_0004978c
obo:BFO_0000051op some obo:TXPO_0005039c
obo:BFO_0000051op some obo:TXPO_0002039c
obo:BFO_0000051op some obo:TXPO_0004377c
obo:BFO_0000051op some obo:TXPO_0004975c
obo:BFO_0000051op some obo:TXPO_0004218c
obo:BFO_0000051op some obo:TXPO_0005109c
obo:BFO_0000051op some obo:TXPO_0004985c
obo:BFO_0000051op some obo:TXPO_0004121c
obo:BFO_0000051op some obo:TXPO_0004821c
obo:BFO_0000051op some obo:TXPO_0001029c
obo:BFO_0000051op some obo:TXPO_0005031c
obo:BFO_0000051op some obo:TXPO_0000869c
obo:BFO_0000051op some obo:TXPO_0004992c
obo:BFO_0000051op some obo:TXPO_0004375c
obo:BFO_0000051op some obo:TXPO_0004127c
obo:BFO_0000051op some obo:TXPO_0004264c
obo:BFO_0000051op some obo:TXPO_0004722c
obo:BFO_0000051op some obo:TXPO_0004342c
obo:BFO_0000051op some obo:TXPO_0004131c
obo:BFO_0000051op some obo:TXPO_0002041c
obo:BFO_0000051op some obo:TXPO_0004341c
obo:BFO_0000051op some obo:TXPO_0004279c
obo:BFO_0000051op some obo:TXPO_0004551c
obo:BFO_0000051op some obo:TXPO_0004946c
obo:BFO_0000051op some obo:TXPO_0005013c
obo:BFO_0000051op some obo:TXPO_0004397c
obo:BFO_0000051op some obo:TXPO_0002009c
obo:BFO_0000051op some obo:TXPO_0004796c
obo:BFO_0000051op some obo:TXPO_0004345c
obo:BFO_0000051op some obo:TXPO_0004374c
obo:BFO_0000051op some obo:TXPO_0004249c
obo:BFO_0000051op some obo:TXPO_0004256c
obo:BFO_0000051op some obo:TXPO_0004720c
obo:BFO_0000051op some obo:TXPO_0002146c

mitochondrial disorder dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001987
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
Sub-classes obo:TXPO_0004978c
obo:TXPO_0004370c
obo:TXPO_0004367c
obo:TXPO_0005044c
obo:TXPO_0004245c
obo:TXPO_0004247c
obo:TXPO_0004975c
obo:TXPO_0004344c
obo:TXPO_0001991c
obo:TXPO_0005031c
obo:TXPO_0004382c
obo:TXPO_0004445c
obo:TXPO_0004120c
obo:TXPO_0005057c
obo:TXPO_0004109c
obo:TXPO_0004374c
obo:TXPO_0004443c
obo:TXPO_0004273c
obo:TXPO_0004270c
obo:TXPO_0004124c
obo:TXPO_0000869c
obo:TXPO_0004243c
obo:TXPO_0004135c
obo:TXPO_0001999c
obo:TXPO_0004261c
obo:TXPO_0004119c
obo:TXPO_0002038c
obo:TXPO_0004796c
obo:TXPO_0001993c
obo:TXPO_0004946c
obo:TXPO_0004461c
obo:TXPO_0001988c
obo:TXPO_0004241c
obo:TXPO_0002004c
obo:TXPO_0004718c
obo:TXPO_0004960c
obo:TXPO_0001990c
obo:TXPO_0004264c
obo:TXPO_0004416c
obo:TXPO_0004242c
obo:TXPO_0002039c
obo:TXPO_0004974c
obo:TXPO_0004444c
obo:TXPO_0004366c
obo:TXPO_0005034c
obo:TXPO_0004256c
obo:TXPO_0003568c
obo:TXPO_0004368c
obo:TXPO_0004559c
obo:TXPO_0004379c
obo:TXPO_0004359c
obo:TXPO_0004278c
obo:TXPO_0004253c
obo:TXPO_0004985c
obo:TXPO_0005106c
obo:TXPO_0004345c
obo:TXPO_0004397c
obo:TXPO_0001879c
obo:TXPO_0004927c
obo:TXPO_0004279c
obo:TXPO_0002040c
obo:TXPO_0004440c
obo:TXPO_0004992c
obo:TXPO_0002005c
obo:TXPO_0004349c
obo:TXPO_0004964c
obo:TXPO_0004127c
obo:TXPO_0004265c
obo:TXPO_0004906c
obo:TXPO_0004990c
obo:TXPO_0004723c
obo:TXPO_0004442c
obo:TXPO_0002146c
obo:TXPO_0005055c
obo:TXPO_0004981c
obo:TXPO_0004373c
obo:TXPO_0004375c
obo:TXPO_0004252c
obo:TXPO_0004797c
obo:TXPO_0004254c
obo:TXPO_0004372c
obo:TXPO_0004976c
obo:TXPO_0004266c
obo:TXPO_0004255c
obo:TXPO_0004340c
obo:TXPO_0004380c
obo:TXPO_0004720c
obo:TXPO_0004351c
obo:TXPO_0004742c
obo:TXPO_0004939c
obo:TXPO_0004307c
obo:TXPO_0004258c
obo:TXPO_0004269c
obo:TXPO_0004348c
obo:TXPO_0004436c
obo:TXPO_0003569c
obo:TXPO_0004377c
obo:TXPO_0004274c
obo:TXPO_0004941c
obo:TXPO_0004741c
obo:TXPO_0004928c
obo:TXPO_0001029c
obo:TXPO_0005009c
obo:TXPO_0004761c
obo:TXPO_0004271c
obo:TXPO_0004383c
obo:TXPO_0004263c
obo:TXPO_0004830c
obo:TXPO_0002009c
obo:TXPO_0004249c
obo:TXPO_0002230c
obo:TXPO_0005039c
obo:TXPO_0001992c
obo:TXPO_0000933c
obo:TXPO_0004350c
obo:TXPO_0004257c
obo:TXPO_0004225c
obo:TXPO_0005013c
obo:TXPO_0001989c
obo:TXPO_0004342c
obo:TXPO_0004833c
obo:TXPO_0004121c
obo:TXPO_0004260c
obo:TXPO_0004937c
obo:TXPO_0004295c
obo:TXPO_0004250c
obo:TXPO_0005115c
obo:TXPO_0005118c
obo:TXPO_0004955c
obo:TXPO_0004717c
obo:TXPO_0005109c
obo:TXPO_0004371c
obo:TXPO_0004376c
obo:TXPO_0004272c
obo:TXPO_0005112c
obo:TXPO_0004325c
obo:TXPO_0004936c
obo:TXPO_0004262c
obo:TXPO_0002010c
obo:TXPO_0004126c
obo:TXPO_0004125c
obo:TXPO_0004246c
obo:TXPO_0001997c
obo:TXPO_0004218c
obo:TXPO_0004259c
obo:TXPO_0004369c
obo:TXPO_0004267c
obo:TXPO_0004821c
obo:TXPO_0004347c
obo:TXPO_0004722c
obo:TXPO_0004131c
obo:TXPO_0004343c
obo:TXPO_0004390c
obo:TXPO_0004956c
obo:TXPO_0004324c
obo:TXPO_0004987c
obo:TXPO_0004551c
obo:TXPO_0004549c
obo:TXPO_0004378c
obo:TXPO_0002041c
obo:TXPO_0004360c
obo:TXPO_0004393c
obo:TXPO_0004251c
obo:TXPO_0004268c
obo:TXPO_0004341c
obo:TXPO_0004281c
obo:TXPO_0004346c
obo:TXPO_0004561c
obo:TXPO_0000075c

ATP depletion [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001988
Super-classes obo:TXPO_0001987c
obo:TXPO_0000485c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001991c
obo:TXPO_0000069op some obo:TXPO_0004263c

negative regulation of respiratory electron transport chain [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001989
Super-classes obo:TXPO_0001987c
obo:TXPO_0002342c
Restrictions obo:BFO_0000051op some obo:TXPO_0004109c
obo:BFO_0000051op some obo:TXPO_0004119c
obo:BFO_0000051op some obo:TXPO_0004120c
obo:TXPO_0000069op some obo:TXPO_0002230c
obo:BFO_0000066op some obo:GO_0005739c

reactive oxygen species biosynthetic process [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001990
Super-classes obo:TXPO_0001987c
obo:GO_1903409c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004341c
obo:TXPO_0000069op some obo:TXPO_0004346c
obo:TXPO_0000069op some obo:TXPO_0004350c
obo:TXPO_0000069op some obo:TXPO_0004324c
obo:TXPO_0000069op some obo:TXPO_0004348c
obo:TXPO_0000069op some obo:TXPO_0004125c
obo:TXPO_0000069op some obo:TXPO_0004249c
obo:TXPO_0000069op some obo:TXPO_0001029c
obo:TXPO_0000069op some obo:TXPO_0004278c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004264c
obo:TXPO_0000069op some obo:TXPO_0000933c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:TXPO_0000069op some obo:TXPO_0004259c
obo:TXPO_0000069op some obo:TXPO_0001991c
obo:TXPO_0000069op some obo:TXPO_0004351c
obo:TXPO_0000069op some obo:TXPO_0004349c
obo:TXPO_0000069op some obo:TXPO_0004121c
obo:TXPO_0000069op some obo:TXPO_0004269c
obo:TXPO_0000069op some obo:TXPO_0004254c
obo:TXPO_0000069op some obo:TXPO_0004347c

positive regulation of mitochondrial membrane permeability [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001991
Super-classes obo:TXPO_0001987c
obo:GO_0035794c
Restrictions obo:RO_0000057op some obo:TXPO_0004356c
obo:RO_0000057op some obo:TXPO_0004358c
obo:RO_0000057op some obo:TXPO_0004353c
obo:RO_0000057op some obo:TXPO_0004355c
obo:RO_0000057op some obo:TXPO_0004337c
obo:TXPO_0000069op some obo:TXPO_0000933c
obo:TXPO_0000069op some obo:TXPO_0001879c
obo:RO_0000057op some obo:TXPO_0004332c
obo:RO_0000057op some obo:TXPO_0004354c
obo:TXPO_0000069op some obo:TXPO_0004263c
obo:RO_0000057op some obo:TXPO_0004331c
obo:TXPO_0000069op some obo:TXPO_0001988c
obo:TXPO_0000069op some obo:TXPO_0001993c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0000057op some obo:TXPO_0004333c
obo:RO_0000057op some obo:TXPO_0004334c
obo:TXPO_0000069op some obo:TXPO_0002039c
obo:TXPO_0000069op some obo:TXPO_0004342c
obo:RO_0000057op some obo:TXPO_0004357c
obo:RO_0000057op some obo:TXPO_0004352c

apoptotic process [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001992
Super-classes obo:GO_0006915c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003568c
obo:TXPO_0000774op only obo:TXPO_0001986c

decreasing mitochondrial membrane potential [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001993
Super-classes obo:TXPO_0001987c
obo:TXPO_0001855c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001992c
obo:TXPO_0000069op some obo:TXPO_0002230c
obo:TXPO_0000069op some obo:TXPO_0004126c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004131c

bile acid and bile salt transport to hepatocyte [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001994
Description

After their uptake into hepatocytes, bile salts reach the canalicular plasma membrane, whch probably involves binding to cytoplasmic proteins.
Super-classes obo:TXPO_0000034c
obo:TXPO_0002693c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

decreasing membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001995
Super-classes obo:TXPO_0001456c
Restrictions obo:TXPO_0000531op some obo:TXPO_0000481c
Sub-classes obo:TXPO_0001855c

antitubercular agentc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001996
Super-classes obo:CHEBI_64912c

malfunctioning of uncoupling [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001997
Super-classes obo:TXPO_0002156c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004124c

chloride channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001998
Super-classes obo:TXPO_0001900c

negative regulation of mitochondrial gene expression [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0001999
Super-classes obo:TXPO_0001987c
obo:TXPO_0002001c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op some obo:GO_0005739c

GCLC inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002000
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0002365c and ub744bL69157C17c)
Sub-classes obo:TXPO_0001955c

negative regulation of mitochondrial gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002001
Description

The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
Super-classes obo:GO_0010629c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0001999c

protein serine/threonine/tyrosine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002002
Description

related molecular function GO:0004712
Super-classes obo:TXPO_0001865c

Acot1 (rat)[Uncoupling]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002003
Super-classes obo:TXPO_0002018c
obo:TXPO_0002014c

lipid storage in liver [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002004
Super-classes obo:TXPO_0001987c
obo:TXPO_0001276c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004359c
obo:TXPO_0000069op some obo:TXPO_0004360c
obo:TXPO_0000774op only obo:TXPO_0001986c

hypofunction of mitochondrial fatty acid beta-oxidation [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002005
Super-classes obo:TXPO_0002112c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004330c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:RO_0000057op some obo:TXPO_0004361c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0000057op some obo:TXPO_0004362c
obo:RO_0000057op some obo:TXPO_0004335c
obo:BFO_0000066op some obo:GO_0005739c
obo:RO_0000057op some obo:TXPO_0004352c
obo:RO_0000057op some obo:TXPO_0004363c
obo:TXPO_0000069op some obo:TXPO_0002040c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:RO_0000057op some obo:TXPO_0004358c
obo:RO_0000057op some obo:TXPO_0004339c
obo:RO_0000057op some obo:TXPO_0004332c
obo:TXPO_0000069op some obo:TXPO_0002230c
obo:RO_0000057op some obo:TXPO_0004364c
obo:RO_0000057op some obo:TXPO_0004353c

hypofunction of lipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002006
Super-classes obo:TXPO_0000940c
Restrictions obo:TXPO_0000716op some obo:GO_0006629c
Sub-classes obo:TXPO_0002007c
obo:TXPO_0001253c
obo:TXPO_0000891c
obo:TXPO_0001829c

hypofunction of fatty acid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002007
Super-classes obo:TXPO_0002006c
Restrictions obo:BFO_0000051op some obo:TXPO_0002147c
obo:RO_0002233op some obo:TXPO_0000834c
Sub-classes obo:TXPO_0002008c
obo:TXPO_0003629c

hypofunction of fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002008
Super-classes obo:TXPO_0002147c
obo:TXPO_0002007c
Restrictions obo:TXPO_0000716op some obo:GO_0006635c
Sub-classes obo:TXPO_0001310c
obo:TXPO_0002112c

changing iron ion concentration [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002009
Super-classes obo:TXPO_0002343c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

mitohagy [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002010
Super-classes obo:GO_0000423c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

perhexiline - fatty acid oxidation inhibitor [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002011
Super-classes obo:TXPO_0002013c
Restrictions obo:RO_0000087op some obo:CHEBI_133190c

mitochondrial damage dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002012
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
Sub-classes obo:TXPO_0003603c
obo:TXPO_0004226c
obo:TXPO_0000400c
obo:TXPO_0004312c
obo:TXPO_0004293c

perhexiline [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002013
Super-classes obo:CHEBI_35553c
obo:TXPO_0003508c
Sub-classes obo:TXPO_0002011c
obo:TXPO_0002030c

uncoupling dependent molecule (rat in vivo)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002014
Description

under construction
Super-classes obo:TXPO_0000400c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0002015c
obo:TXPO_0002028c
obo:TXPO_0002024c
obo:TXPO_0002020c
obo:TXPO_0002003c
obo:TXPO_0002022c
obo:TXPO_0002016c

Ucp3 (rat)[Uncoupling]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002015
Description

GENATLAS Biochemistry: uncoupling protein of inner mitochondrial membrane 3,with two forms,long and short missing C terminal 37 residues,dissipating the proton electrochemical gradient by uncoupling fuel oxidation from ADP-ATP conversion,highly expressed in skeletal muscle during development,regulated by nutritional factors,possible mediator of adaptive thermogenesis,involved in the variation of energy metabolism and obesity,regulated by PPARA and PPARG in mice,and dysregulated in states of insulin resistance,increased expression in function of obesity and in type 2 diabetes (NIDDM) UCP3

UniProtKB/Swiss-Prot Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. UCP3_HUMAN,P55916
Super-classes obo:TXPO_0002014c
obo:TXPO_1000393c

Acot12 (rat)[Uncoupling]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002016
Super-classes obo:TXPO_1000021c
obo:TXPO_0002014c

Acot1 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002017
Super-classes obo:TXPO_0002018c
obo:TXPO_0000648c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Acot1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002018
Super-classes obo:TXPO_0001146c
Restrictions obo:TXPO_0000819op some obo:OGG_3000641371c
Sub-classes obo:TXPO_0002017c
obo:TXPO_0002003c

tamoxifen -mitochondrial respiratory chain inhibitor [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002019
Super-classes obo:TXPO_0000787c
Restrictions obo:RO_0000087op some obo:CHEBI_25355c

Smarcd3 (rat)[Uncoupling]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002020
Super-classes obo:TXPO_1000345c
obo:TXPO_0002014c

moving lipid to the hepatocye [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002021
Super-classes obo:TXPO_0001729c
obo:TXPO_0001270c
Restrictions obo:BFO_0000051op some obo:TXPO_0002021c
obo:TXPO_0000774op only obo:TXPO_0000028c

Angptl4 (rat)[Uncoupling]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002022
Super-classes obo:TXPO_1000002c
obo:TXPO_0002014c

eosinophilic granular degeneration with hypertrophy　[toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002023
Super-classes obo:TXPO_0000028c
Restrictions obo:BFO_0000051op some obo:TXPO_0000096c
obo:BFO_0000051op some obo:TXPO_0002025c
obo:TXPO_0000004op some obo:TXPO_0001023c
obo:BFO_0000051op some obo:TXPO_0001023c
obo:BFO_0000051op some obo:TXPO_0001010c

Fgf2 (rat)[Uncoupling]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002024
Super-classes obo:TXPO_0002014c
obo:TXPO_1000144c

increasing hepatocellular volume (moderate) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002025
Super-classes obo:TXPO_0000165c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000096c
obo:TXPO_0000774op only obo:TXPO_0000028c

amiodarone -mitochondrial respiratory chain inhibitor [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002026
Super-classes obo:TXPO_0000880c
Restrictions obo:RO_0000087op some obo:CHEBI_25355c

increasing hepatocellular volume (mild) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002027
Super-classes obo:TXPO_0000165c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

Stard7 (rat)[Uncoupling]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002028
Super-classes obo:TXPO_0002014c
obo:TXPO_1000353c

increasing hepatocellular volume (severe) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002029
Super-classes obo:TXPO_0000165c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000096c
obo:TXPO_0000774op only obo:TXPO_0000028c

pergexiline -mitochondrial respiratory chain inhibitor [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002030
Super-classes obo:TXPO_0002013c
Restrictions obo:RO_0000087op some obo:CHEBI_25355c

oxidative phosphorylation inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002031
Super-classes obo:TXPO_0004023c
Restrictions obo:RO_0002599op some obo:GO_0006119c

GSTA2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002032
Super-classes obo:TXPO_0002089c

diabetes coursec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002033
Super-classes obo:OGMS_0000063c
Restrictions obo:BFO_0000051op some obo:TXPO_0003290c
obo:BFO_0000051op some obo:TXPO_0003289c
obo:TXPO_0003585op some obo:DOID_9351c
Sub-classes obo:TXPO_0002671c
obo:TXPO_0003291c
obo:TXPO_0003042c

hypofunction of electron transport coupled proton transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002034
Super-classes obo:TXPO_0000495c
Restrictions obo:TXPO_0000716op some obo:GO_0015990c

ibuprofen [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002035
Super-classes obo:TXPO_0003508c
obo:CHEBI_5855c
Sub-classes obo:TXPO_0002036c

ibuprofen - oxidative phosphorylation inhibitor [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002036
Super-classes obo:TXPO_0002035c
Restrictions obo:RO_0000087op some obo:TXPO_0002031c

glutathione conjuation regulating agent rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002037
Super-classes obo:TXPO_0004023c
Sub-classes obo:TXPO_0002044c
obo:CHEBI_68509c

leaking proton ion [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002038
Super-classes obo:TXPO_0001987c
obo:TXPO_0002341c
Restrictions obo:RO_0002233op some obo:CHEBI_24636c
obo:TXPO_0000774op only obo:TXPO_0001986c

oxidative phosphorylation uncoupling [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002039
Super-classes obo:TXPO_0001987c
obo:TXPO_0004133c
Restrictions obo:RO_0000057op some obo:TXPO_0004365c
obo:RO_0000057op some obo:TXPO_0004333c
obo:RO_0000057op some obo:TXPO_0004339c
obo:RO_0000057op some obo:TXPO_0004330c
obo:RO_0000057op some obo:TXPO_0004362c
obo:RO_0000057op some obo:TXPO_0004332c
obo:RO_0000057op some obo:TXPO_0004335c
obo:RO_0000057op some obo:TXPO_0004353c
obo:RO_0000057op some obo:TXPO_0004354c
obo:RO_0000057op some obo:TXPO_0004352c

fatty acid strorage [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002040
Super-classes obo:TXPO_0001987c
obo:TXPO_0000256c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004126c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:TXPO_0000069op some obo:TXPO_0004249c
obo:TXPO_0000069op some obo:TXPO_0004366c
obo:TXPO_0000069op some obo:TXPO_0004125c
obo:TXPO_0000069op some obo:TXPO_0002041c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004368c
obo:TXPO_0000069op some obo:TXPO_0004367c

PPARalpha activation [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002041
Super-classes obo:TXPO_0000013c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004360c
obo:TXPO_0000069op some obo:TXPO_0004369c

nimesulide [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002042
Super-classes obo:CHEBI_44445c
obo:TXPO_0003508c
Sub-classes obo:TXPO_0002043c

nimesulide [lipidosis - oxidative phosphorylation inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002043
Super-classes obo:TXPO_0002042c
Restrictions obo:RO_0000087op some obo:TXPO_0002031c

glutathione conjugation inhibotor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002044
Super-classes obo:TXPO_0002037c
obo:TXPO_0000638c
Restrictions obo:RO_0002596op some obo:TXPO_0003991c

glutathione depletion dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002045
Super-classes obo:TXPO_0001915c
Sub-classes obo:TXPO_0000228c
obo:TXPO_0003190c
obo:TXPO_0002512c
obo:TXPO_0003805c
obo:TXPO_0001929c
obo:TXPO_0000850c
obo:TXPO_0002392c
obo:TXPO_0003162c
obo:TXPO_0003194c
obo:TXPO_0000135c
obo:TXPO_0003172c
obo:TXPO_0001172c
obo:TXPO_0003164c
obo:TXPO_0003192c
obo:TXPO_0002493c
obo:TXPO_0003165c
obo:TXPO_0003193c
obo:TXPO_0003166c
obo:TXPO_0002298c
obo:TXPO_0002787c
obo:TXPO_0000000c
obo:TXPO_0003167c
obo:TXPO_0003170c
obo:TXPO_0000137c
obo:TXPO_0002300c
obo:TXPO_0003171c
obo:TXPO_0000229c
obo:TXPO_0000193c
obo:TXPO_0003191c
obo:TXPO_0002792c

changing forcec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002046
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0002064c

regulation of lipolytic gene expression [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002047
Super-classes obo:TXPO_0002545c
obo:TXPO_0001729c
Restrictions obo:RO_0000057op some obo:TXPO_0002062c
obo:TXPO_0000774op only obo:TXPO_0000028c

hypofunction of carbohydrate transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002048
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:GO_0008643c
Sub-classes obo:TXPO_0001011c

hyperfunction of drug metabolism phase Ic # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002049
Super-classes obo:TXPO_0002347c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000173c
Sub-classes obo:TXPO_0000938c
obo:TXPO_0001623c
obo:TXPO_0001551c

decreasing glycogen levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002050
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0003789c

hyperfunction of Cyp gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002051
Super-classes obo:TXPO_0002332c
Sub-classes obo:TXPO_0003874c
obo:TXPO_0001627c
obo:TXPO_0001181c
obo:TXPO_0000937c
obo:TXPO_0003858c
obo:TXPO_0004493c

hyperfunction of electron transport from NADH to cytochrome P450c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002052
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:GO_0022900c
Sub-classes obo:TXPO_0000941c

dioxins and dioxin-like compounds accumulation in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002053
Super-classes obo:TXPO_0001694c
Sub-classes obo:TXPO_0000987c

negative regulation of heat generationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002054
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0031649c
Sub-classes obo:TXPO_0004124c

mitotic G2/M transition checkpointc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002055
Super-classes obo:TXPO_0000370c

negative regulation of glutathione conjugationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002056
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0003991c
Sub-classes obo:TXPO_0001188c

negative regulation of cell proliferation inhibitor expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002057
Super-classes obo:GO_0010629c
Sub-classes obo:TXPO_0000983c

hyperfunction of reductionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002058
Super-classes obo:TXPO_0000435c
Sub-classes obo:TXPO_0001302c

decreasing negative regulator of G1/S transitionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002059
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0000959c

insufficient detoxificationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002060
Super-classes obo:TXPO_0000482c

antioxidant gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002061
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0000656c
obo:TXPO_0002618c

LPL (canonical)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002062
Super-classes obo:TXPO_0001280c
obo:TXPO_0000282c

hyprerfunction of anti-oxidative stressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002063
Super-classes obo:TXPO_0000435c
Sub-classes obo:TXPO_0002368c

decreasing proton motive forcec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002064
Super-classes obo:TXPO_0002046c
Sub-classes obo:TXPO_0002146c

coumarin [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002065
Super-classes obo:TXPO_0001921c
obo:CHEBI_28794c

CAR bindingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002066
Super-classes obo:GO_0005488c
Sub-classes obo:TXPO_0000980c

GSTA4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002067
Super-classes obo:TXPO_0002089c

chemical compound accumulation in liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002068
Super-classes obo:TXPO_0001694c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0001848c
obo:TXPO_0000934c
obo:TXPO_0001668c

dysfunction of phospholipid degradation [Phospholipidosis - genetic]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002069
Super-classes obo:TXPO_0001448c
obo:TXPO_0001447c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001776c
obo:TXPO_0000774op only obo:TXPO_0001437c
Sub-classes obo:TXPO_0001687c

phospholipid accumulation in lysosome [Phospholipidosis - genetic- sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002070
Super-classes obo:TXPO_0000910c
Restrictions obo:RO_0000086op only obo:TXPO_0000854c
obo:TXPO_0000774op only obo:TXPO_0001437c
Sub-classes obo:TXPO_0001690c

liver malfunction [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002071
Super-classes obo:TXPO_0001716c
obo:TXPO_0002074c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001462c

spleen malfunction [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002072
Super-classes obo:TXPO_0001716c
obo:TXPO_0002075c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001462c

organ malfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002073
Super-classes obo:TXPO_0000434c
Restrictions obo:BFO_0000066op some obo:UBERON_0000062c
obo:TXPO_0001518op some obo:TXPO_0000378c
Sub-classes obo:TXPO_0002074c
obo:TXPO_0001344c
obo:TXPO_0001343c
obo:TXPO_0003292c
obo:TXPO_0002075c

liver malfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002074
Super-classes obo:TXPO_0002073c
Sub-classes obo:TXPO_0004758c
obo:TXPO_0004281c
obo:TXPO_0002071c

spleen malfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002075
Super-classes obo:TXPO_0002073c
Sub-classes obo:TXPO_0002072c

toxicological imbalance M=M (maintining homeostasis in the normal condition)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002076
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL70085C17c and obo:TXPO_0001746c and ub744bL70107C17c)
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL70085C17c and obo:TXPO_0001746c and ub744bL70107C17c)
obo:BFO_0000051op some obo:TXPO_0001734c

chemical compound excretionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002077
Super-classes obo:TXPO_0000631c
Sub-classes obo:TXPO_0003152c
obo:TXPO_0003153c
obo:TXPO_0002551c
obo:TXPO_0002078c

chemical compound excretion [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002078
Super-classes obo:TXPO_0002077c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002252c
obo:TXPO_0000774op only obo:TXPO_0002215c

decreasing demand for phospholipid degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002079
Super-classes obo:TXPO_0002082c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

decreasing demandc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002080
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0002081c

decreasing functional demandc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002081
Super-classes obo:TXPO_0002080c
Sub-classes obo:TXPO_0002082c

decreasing demand for phospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002082
Super-classes obo:TXPO_0002081c
Sub-classes obo:TXPO_0002079c

increasing phospholipid metabolite [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002083
Super-classes obo:TXPO_0004143c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c

decreasing phospholipidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002084
Super-classes obo:TXPO_0000644c
Sub-classes obo:TXPO_0002085c

decreasing phospholipid [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002085
Super-classes obo:TXPO_0002084c
obo:TXPO_0001716c
Restrictions obo:BFO_0000051op some obo:TXPO_0002255c
obo:BFO_0000051op some obo:TXPO_0000200c
obo:BFO_0000051op some obo:TXPO_0003395c
obo:BFO_0000051op some obo:TXPO_0003354c
obo:BFO_0000051op some obo:TXPO_0002258c
obo:BFO_0000051op some obo:TXPO_0003390c
obo:BFO_0000051op some obo:TXPO_0001485c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0003384c
obo:BFO_0000051op some obo:TXPO_0001406c

increasing lysosomal pH [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002086
Super-classes obo:TXPO_0001247c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003372c
obo:TXPO_0000774op only obo:TXPO_0003369c
obo:TXPO_0000069op some obo:TXPO_0003370c

negative regulation of phospholipid degradation [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002087
Super-classes obo:TXPO_0000905c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002088c
obo:TXPO_0000774op only obo:TXPO_0003359c
obo:BFO_0000051op some obo:TXPO_0001403c

hypofunction of phospholipid degradation [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002088
Super-classes obo:TXPO_0000925c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001406c
obo:TXPO_0000069op some obo:TXPO_0001777c
obo:RO_0000057op some obo:TXPO_0000775c
obo:RO_0000057op some obo:TXPO_0001804c
obo:TXPO_0000774op only obo:TXPO_0003359c

glutathione transferase familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002089
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0002067c
obo:TXPO_0002104c
obo:TXPO_0002205c
obo:TXPO_0002181c
obo:TXPO_0002127c
obo:TXPO_0002179c
obo:TXPO_0002186c
obo:TXPO_0002120c
obo:TXPO_1000180c
obo:TXPO_0002206c
obo:TXPO_0002151c
obo:TXPO_0002121c
obo:TXPO_0002185c
obo:TXPO_0002180c
obo:TXPO_0002032c
obo:TXPO_0002208c
obo:TXPO_0001947c
obo:TXPO_1000179c
obo:TXPO_0002093c

SGPL1(human) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002090
Super-classes obo:TXPO_0001135c
obo:TXPO_0000014c
Sub-classes obo:TXPO_0003531c
obo:TXPO_0003380c

malfunctioning of phospholipid metabolism [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002091
Super-classes obo:TXPO_0002092c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

malfunctioning of phospholipid metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002092
Super-classes obo:TXPO_0000532c
Sub-classes obo:TXPO_0002091c

GSTM1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002093
Super-classes obo:TXPO_0002089c

lysosome damage [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002094
Super-classes obo:TXPO_0000059c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000797c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0002095c
obo:TXPO_0000069op some obo:TXPO_0002240c

lysosomal enzyme leakage [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002095
Super-classes obo:TXPO_0002096c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002097c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001400c

lysosomal enzyme leakagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002096
Super-classes obo:TXPO_0001699c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
Sub-classes obo:TXPO_0002095c

autolysis [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002097
Super-classes obo:TXPO_0001716c
obo:TXPO_0002235c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000539c

dysfunction of phospholipid degradation [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002098
Super-classes obo:TXPO_0001448c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001778c
obo:TXPO_0000774op only obo:TXPO_0003452c

increasing drug metabolite [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002099
Super-classes obo:TXPO_0001727c
obo:TXPO_0002364c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000678c
obo:TXPO_0000069op some obo:TXPO_0002409c

negative regulation of apoptotic process [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002100
Super-classes obo:TXPO_0001729c
obo:GO_0043066c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

negative regulation of insulin receptor signaling pathway [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002101
Super-classes obo:TXPO_0002102c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0000779c
obo:RO_0002212op some obo:TXPO_0000993c

negative regulation of insulin receptor signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002102
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:TXPO_0000477c
obo:RO_0002212op some obo:GO_0008286c
Sub-classes obo:TXPO_0002101c

negative regulation of AKT signaling [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002103
Super-classes obo:TXPO_0003736c
obo:GO_0051898c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002101c
obo:TXPO_0001868op some obo:TXPO_0000779c
obo:TXPO_0001868op some obo:TXPO_0002168c
obo:TXPO_0000774op only obo:TXPO_0002528c

GSTM2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002104
Super-classes obo:TXPO_0002089c

AKT (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002105
Super-classes obo:IMR_0100844c
obo:TXPO_0000871c

unfolded proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002106
Super-classes obo:GOCHE_50906c
Sub-classes obo:TXPO_0000132c

molecular complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002107
Super-classes obo:BFO_0000027c
Sub-classes obo:TXPO_0004850c
obo:TXPO_0002115c
obo:TXPO_0004237c
obo:GO_0098800c
obo:TXPO_0002405c
obo:GO_0061702c
obo:IMR_0100470c
obo:IMR_0000414c
obo:IMR_0000243c

BIP-STRESS sensor complex (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002108
Super-classes obo:TXPO_0000871c
obo:TXPO_0002405c
obo:TXPO_1000047c
Restrictions obo:RO_0002180op some obo:TXPO_0002385c
Sub-classes obo:TXPO_0002111c
obo:TXPO_0002110c
obo:TXPO_0002109c

BIP-PERK complex (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002109
Super-classes obo:TXPO_0002108c
Restrictions obo:RO_0002180op some obo:TXPO_0002619c
obo:RO_0002180op some obo:TXPO_0001841c

BIP-ATF6 complex (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002110
Super-classes obo:TXPO_0002108c
Restrictions obo:RO_0002180op some obo:TXPO_0002622c
obo:BFO_0000051op some obo:TXPO_0000879c

BIP-IRE1 complex (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002111
Super-classes obo:TXPO_0002108c
Restrictions obo:RO_0002180op some obo:TXPO_0002621c

hypofunction of mitochondrial fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002112
Super-classes obo:TXPO_0002008c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0002171c
obo:TXPO_0002005c
obo:TXPO_0001450c
obo:TXPO_0000901c

glutathione depletion [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002113
Super-classes obo:TXPO_0000483c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002116c
obo:RO_0000057op some obo:TXPO_0000807c

positive regulation of apoptotic process [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002114
Super-classes obo:GO_0043065c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000513c
obo:RO_0000057op some obo:TXPO_0003818c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002916c

Bip-unfolded protein complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002115
Super-classes obo:TXPO_0002107c
Restrictions obo:RO_0002180op some obo:TXPO_0000132c
obo:RO_0002180op some obo:TXPO_0002385c
Sub-classes obo:TXPO_0003157c

cell cycle arrest [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002116
Super-classes obo:GO_0007050c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002114c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002990c

forming disulfide bond [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002117
Super-classes obo:TXPO_0001717c
obo:TXPO_0002118c
Restrictions obo:RO_0000057op some obo:TXPO_0000805c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002771c
obo:RO_0000057op some obo:TXPO_0002497c

forming disulfide bondc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002118
Description

In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′. The linkage is also called an SS-bond or sometimes a disulfide bridge and is usually derived by the coupling of two thiol groups.

Occurrence in proteins Disulfide bonds play an important role in the folding and stability of some proteins, usually proteins secreted to the extracellular medium. Since most cellular compartments are reducing environments, in general, disulfide bonds are unstable in the cytosol, with some exceptions as noted below, unless a sulfhydryl oxidase is present.

Disulfide bonds in proteins are formed between the thiol groups of cysteine residues by the process of oxidative folding. The other sulfur-containing amino acid, methionine, cannot form disulfide bonds. A disulfide bond is typically denoted by hyphenating the abbreviations for cysteine, e.g., when referring to ribonuclease A the "Cys26–Cys84 disulfide bond", or the "26–84 disulfide bond", or most simply as "C26–C84"　where the disulfide bond is understood and does not need to be mentioned. The prototype of a protein disulfide bond is the two-amino-acid peptide cystine, which is composed of two cysteine amino acids joined by a disulfide bond (shown in Figure 3 in its unionized form). The structure of a disulfide bond can be described by its χss dihedral angle between the Cβ−Sγ−Sγ−Cβ atoms, which is usually close to ±90°.
Super-classes obo:GO_0005488c
Sub-classes obo:TXPO_0002788c
obo:TXPO_0002117c

PERK - signaling factor (canonical)[Perk-eIF2a signalling system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002119
Super-classes obo:TXPO_0001852c
Restrictions obo:TXPO_0001896op some obo:TXPO_0000062c
obo:RO_0000087op some obo:TXPO_0001898c
Sub-classes obo:TXPO_0002729c
obo:TXPO_0002162c
obo:TXPO_0002850c
obo:TXPO_0003003c
obo:TXPO_0002728c

GSTM4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002120
Super-classes obo:TXPO_0002089c

GSTM5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002121
Super-classes obo:TXPO_0002089c

cell invasion into other cell [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002122
Super-classes obo:TXPO_0002123c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002387c
obo:TXPO_0000774op only obo:TXPO_0000323c

cell invasion into other cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002123
Super-classes obo:TXPO_0002587c
Sub-classes obo:TXPO_0002122c

negative regulation of tumor cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002124
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0000339c
Sub-classes obo:TXPO_0004132c
obo:TXPO_0002125c

negative regulation of tumor cell proliferation [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002125
Super-classes obo:TXPO_0002124c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

ATF6 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002126
Super-classes obo:TXPO_0000609c
Restrictions obo:BFO_0000051op some obo:TXPO_0000718c
Sub-classes obo:GO_0036500c

GSTO1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002127
Super-classes obo:TXPO_0002089c

negative regulation of autophagy [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002128
Super-classes obo:TXPO_0001727c
obo:GO_0010507c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

metabolic dysfunction [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002129
Super-classes obo:TXPO_0002131c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002387c

malfunctioning of metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002130
Super-classes obo:TXPO_0000434c
Restrictions obo:TXPO_0001518op some obo:GO_0008152c
Sub-classes obo:TXPO_0001269c

metabolic dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002131
Super-classes obo:TXPO_0000438c
Sub-classes obo:TXPO_0005050c
obo:TXPO_0002129c
obo:TXPO_0004305c

changing fatty acid homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002132
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0002133c

changing fatty acid homeostasis in peroxisomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002133
Super-classes obo:TXPO_0002132c
Sub-classes obo:TXPO_0002446c
obo:TXPO_0002134c

changing fatty acid homeostasis in peroxisome [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002134
Super-classes obo:TXPO_0002133c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000105c
obo:TXPO_0000774op only obo:TXPO_0000028c
Sub-classes obo:TXPO_0002158c

regulation of gene expression by p53 [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002135
Super-classes obo:TXPO_0001727c
obo:TXPO_0002136c
Restrictions obo:RO_0000057op some obo:TXPO_0000845c
obo:RO_0000057op some obo:TXPO_0000650c
obo:RO_0000057op some obo:TXPO_0000640c
obo:TXPO_0000069op some obo:TXPO_0000448c
obo:RO_0000057op some obo:TXPO_0000843c
obo:RO_0000057op some obo:TXPO_0000653c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000374c

regulation of gene expression by p53c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002136
Super-classes obo:GO_0010468c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000843c
Sub-classes obo:TXPO_0002135c

DNA repair [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002137
Super-classes obo:GO_0006281c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000377c

membrane phospholipid catabolic process [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002138
Super-classes obo:TXPO_0000393c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

pathogen proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002139
Super-classes obo:TXPO_0000093c
Restrictions obo:RO_0002234op some (ub744bL70958C33c and ub744bL70968C17c)
Sub-classes obo:TXPO_0004594c
obo:TXPO_0001477c
obo:TXPO_0002140c
obo:TXPO_0004584c

pathogen proliferation [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002140
Super-classes obo:TXPO_0002139c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002141c

hyperfunction of immune response [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002141
Super-classes obo:TXPO_0001486c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003830c
obo:TXPO_0000774op only obo:TXPO_0000323c

inflammatory response [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002142
Super-classes obo:TXPO_0000192c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002144c

ATF6-mediated unfolded protein response [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002143
Super-classes obo:GO_0036500c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002384c
obo:BFO_0000051op some obo:TXPO_0000719c
obo:BFO_0000051op some obo:TXPO_0002447c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002393c

pyroptosis [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002144
Super-classes obo:GO_0070269c
obo:TXPO_0000008c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

PERK-mediated unfolded protein response [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002145
Super-classes obo:GO_0036499c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

decreasing proton motive force [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002146
Super-classes obo:TXPO_0001987c
obo:TXPO_0002064c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

hypofunction of fatty acid oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002147
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0019395c
Sub-classes obo:TXPO_0001036c
obo:TXPO_0002008c
obo:TXPO_0003629c

anoikis (course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002148
Description

under construction
Super-classes obo:TXPO_0000323c
Restrictions obo:BFO_0000051op min 1 obo:TXPO_0000512c
obo:BFO_0000051op some obo:TXPO_0000239c
obo:BFO_0000051op some obo:TXPO_0000246c

netosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002149
Super-classes obo:GO_0008219c

importing cation into hepatocyte vascular side (sinusoidal side) membrane [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002150
Description

Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids.
Super-classes obo:TXPO_0001759c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002386c

GSTO2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002151
Super-classes obo:TXPO_0002089c

collagenase inhibitor production [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002152
Super-classes obo:TXPO_0002153c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c

collagenase inhibitor productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002153
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0002152c

transmembrane receptor protein serine/threonine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002154
Description

related molecular function GO:0004675
Super-classes obo:TXPO_0001966c

IRE1 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002155
Super-classes obo:TXPO_0000609c
Restrictions obo:BFO_0000051op some obo:TXPO_0002593c
Sub-classes obo:GO_0036498c

malfunctioning of uncouplingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002156
Super-classes obo:TXPO_0000434c
Sub-classes obo:TXPO_0001997c

PERK-eIF2a signaling (integrated pathway)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002157
Super-classes obo:TXPO_0000701c
Restrictions obo:BFO_0000051op some obo:TXPO_0000123c
obo:BFO_0000051op some obo:TXPO_0002762c
obo:TXPO_0000774op only obo:TXPO_0000722c
obo:BFO_0000051op some obo:TXPO_0000061c

fatty acid homeostasis imbalance in peroxisome [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002158
Super-classes obo:TXPO_0002134c
obo:TXPO_0002446c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000105c
obo:TXPO_0000774op only obo:TXPO_0000028c
Sub-classes obo:TXPO_0002160c
obo:TXPO_0002391c
obo:TXPO_0002159c

fatty acid homeostasis imbalance in peroxisome (mild) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002159
Super-classes obo:TXPO_0002158c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

fatty acid homeostasis imbalance in peroxisome (moderate) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002160
Super-classes obo:TXPO_0002158c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

protein unfolding [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002161
Super-classes obo:TXPO_0001717c
obo:GO_0043335c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0002458c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0001965c
obo:TXPO_0000012op some obo:TXPO_0000037c

PERK - signaling factor (canonical)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002162
Super-classes obo:TXPO_0002119c
Restrictions obo:TXPO_0001896op some obo:TXPO_0000061c

lipid biosynthetic process [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002163
Super-classes obo:TXPO_0001717c
obo:GO_0008610c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:RO_0000057op some obo:TXPO_0001968c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002172c
obo:RO_0000057op some obo:TXPO_0003819c

Hyou1 (rat)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002164
Super-classes obo:TXPO_1000191c
obo:TXPO_0000753c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
obo:TXPO_0000756op some obo:TXPO_0000489c

DNAJB9 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002165
Description

IRE1->Xbp1->DNAJB9
Super-classes obo:TXPO_0000793c
obo:TXPO_1000114c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004189c
obo:RO_0000087op some obo:TXPO_0003997c
obo:RO_0000087op some obo:CHEBI_68494c
obo:TXPO_0000756op some obo:TXPO_0000795c
Sub-classes obo:TXPO_0000801c
obo:TXPO_0003471c

ATF3 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002166
Description

PERK->ATF4->ATF3 reactome
Super-classes obo:TXPO_0000793c
obo:TXPO_1000011c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000467c
obo:RO_0000087op some obo:TXPO_0000329c
obo:TXPO_0002260op some obo:IMR_0000825c
obo:RO_0000087op some obo:TXPO_0003645c
obo:TXPO_0000756op some ncicp:C15958c

DDIT3 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002167
Super-classes obo:TXPO_0000793c
obo:TXPO_1000067c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0000819op some obo:OGG_3000001649c
obo:TXPO_0002260op some obo:IMR_0000422c
obo:TXPO_0000756op some obo:TXPO_0000795c

TRIB3 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002168
Super-classes obo:TXPO_0000793c
obo:TXPO_1000378c
Restrictions obo:TXPO_0000819op some obo:OGG_3000057761c
obo:TXPO_0000756op some obo:TXPO_0000795c

CRELD2 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002169
Super-classes obo:TXPO_1000075c
obo:TXPO_0000793c
Restrictions obo:RO_0000056op some obo:TXPO_0000719c
obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000079174c

dysfunction of mitochondrial respiratory electron transport chainc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002170
Super-classes obo:TXPO_0000438c

hypofunction of mitochondrial fatty acid beta-oxidation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002171
Super-classes obo:TXPO_0001717c
obo:TXPO_0002112c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0002172c

lipid storage in liver [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002172
Super-classes obo:TXPO_0001276c
obo:TXPO_0001717c
Restrictions obo:RO_0000057op some obo:TXPO_0003819c
obo:TXPO_0000774op only obo:TXPO_0002528c

cell proliferation [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002173
Super-classes obo:GO_0008283c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0001037c

receiving signalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002174
Super-classes obo:TXPO_0000379c
Restrictions obo:TXPO_0000069op some obo:GO_0023052c
obo:RO_0002233op some (obo:BFO_0000002c and ub744bL71517C17c)
Sub-classes obo:TXPO_0002554c
obo:TXPO_0001837c
obo:TXPO_0002604c

protein refolding (sustained) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002175
Super-classes obo:GO_0042026c
obo:TXPO_0001717c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000801c
obo:RO_0002234op some obo:TXPO_0000561c
obo:TXPO_0000069op some obo:TXPO_0002460c
obo:TXPO_0001868op some obo:TXPO_0000828c
obo:TXPO_0001868op some obo:TXPO_0000783c
obo:TXPO_0001868op some obo:TXPO_0002677c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002164c

Dissociation of IRE1:BIP Heterodimer [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002176
Super-classes obo:TXPO_0000505c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000730c
obo:RO_0002234op some obo:TXPO_0002601c
Sub-classes obo:TXPO_0002885c

protein refolding insufficiency [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002177
Super-classes obo:TXPO_0002474c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0002458c
Sub-classes obo:TXPO_0002475c

toxicological rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002178
Super-classes obo:BFO_0000023c
Sub-classes obo:TXPO_0002193c
obo:TXPO_0003156c
obo:TXPO_0000854c

GSTK1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002179
Super-classes obo:TXPO_0002089c

GSTP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002180
Super-classes obo:TXPO_0002089c

GSTT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002181
Super-classes obo:TXPO_0002089c

pancreatic beta cell damagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002182
Super-classes obo:TXPO_0000225c
Sub-classes obo:TXPO_0002435c

abnormal protein productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002183
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0002499c

protein glycosylation inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002184
Description

related process: GO:0060051
Super-classes obo:TXPO_0003230c

GSTT2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002185
Super-classes obo:TXPO_0002089c

GSTT2B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002186
Super-classes obo:TXPO_0002089c

accumulation of abnormal proteins in ERc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002187
Super-classes obo:TXPO_0000251c
Sub-classes obo:TXPO_0000194c
obo:TXPO_0000922c
obo:TXPO_0003527c
obo:TXPO_0003528c

hypofunction of carbohydrate metabolism [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002188
Super-classes obo:TXPO_0001326c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002201c
obo:TXPO_0000774op only obo:TXPO_0002528c

insulin resistance (process)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002189
Super-classes obo:TXPO_0000157c
Sub-classes obo:TXPO_0003496c
obo:TXPO_0003576c
obo:TXPO_0004347c
obo:TXPO_0002201c

hypofunction of drug metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002190
Super-classes obo:TXPO_0002354c
Restrictions obo:TXPO_0000716op some obo:GO_0017144c
Sub-classes obo:TXPO_0001775c
obo:TXPO_0002191c
obo:TXPO_0001550c
obo:TXPO_0002330c
obo:TXPO_0001766c

hypofunction of drug metabolism [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002191
Super-classes obo:TXPO_0002190c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

hypofunction of sequestering of calcium ionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002192
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0001868op some obo:GO_0005783c
obo:BFO_0000066op some obo:GO_0005783c
Sub-classes obo:TXPO_0004349c
obo:TXPO_0002194c

adaptive responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002193
Super-classes obo:TXPO_0002178c

hypofunction of sequestering of calcium ion [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002194
Super-classes obo:TXPO_0001717c
obo:TXPO_0002192c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0001810c
obo:TXPO_0000774op only obo:TXPO_0002528c

hypofunction of lipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002195
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000716op some obo:GO_0008610c
Sub-classes obo:TXPO_0001413c
obo:TXPO_0004723c
obo:TXPO_0001327c
obo:TXPO_0004926c

lipid synthesis regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002196
Super-classes obo:TXPO_0002358c
Restrictions obo:RO_0002596op some obo:GO_0008610c
Sub-classes obo:TXPO_0003967c

malfunction of lipid biosynthesis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002197
Super-classes obo:TXPO_0001717c
obo:TXPO_0003268c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002199c

malfunctioning of cellular membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002198
Super-classes obo:TXPO_0000434c
Restrictions obo:BFO_0000066op some obo:TXPO_0000895c
Sub-classes obo:TXPO_0002222c
obo:TXPO_0003511c
obo:TXPO_0002199c

malfunctioning of cellular membrane [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002199
Super-classes obo:TXPO_0002198c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002200c

necrosis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002200
Super-classes obo:TXPO_0001717c
obo:GO_0070265c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000342c

insulin resistance (process) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002201
Super-classes obo:TXPO_0001717c
obo:TXPO_0002189c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000074c
obo:RO_0000057op some obo:TXPO_0002411c
obo:TXPO_0000069op some obo:TXPO_0002172c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0001968c

hepatic cirrhosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002202
Super-classes obo:TXPO_0000424c
Restrictions obo:TXPO_0000531op some obo:PATO_0000386c
Sub-classes obo:TXPO_0004453c
obo:TXPO_0002203c
obo:TXPO_0002264c

hepatic cirrhosis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002203
Super-classes obo:TXPO_0001717c
obo:TXPO_0002202c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

ER-associated misfolded protein catabolic process [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002204
Super-classes obo:GO_0071712c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002479c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0000456c
obo:BFO_0000051op some obo:TXPO_0000516c
obo:BFO_0000066op some obo:GO_0005737c

MGST1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002205
Super-classes obo:TXPO_0002089c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004257c

MGST2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002206
Super-classes obo:TXPO_0002089c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004258c

protein refolding [ER stress (early stage)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002207
Super-classes obo:GO_0042026c
obo:TXPO_0001717c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002540c
obo:BFO_0000051op some obo:TXPO_0002117c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002458c

MGST3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002208
Super-classes obo:TXPO_0002089c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004259c

hypofunction of ATP biosynthesis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002209
Super-classes obo:TXPO_0001722c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002200c
obo:TXPO_0000774op only obo:TXPO_0002528c

increasing demand for protein refolding [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002210
Super-classes obo:TXPO_0002211c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0002458c

increasing demand for protein refoldingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002211
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0002210c
obo:TXPO_0002469c

accumulation of compound in ERc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002212
Super-classes obo:TXPO_0000169c
Restrictions obo:BFO_0000066op only obo:GO_0005783c
obo:RO_0002233op some obo:CHEBI_24431c
Sub-classes obo:TXPO_0002503c
obo:TXPO_0000170c

Dissociation of PERK:BIP Heterodimer [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002213
Description

PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.
Super-classes obo:TXPO_0000505c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0003157c
obo:RO_0002234op some obo:TXPO_0000878c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000713c
Sub-classes obo:TXPO_0002995c
obo:TXPO_0002865c
obo:TXPO_0001835c
obo:TXPO_0000463c
obo:TXPO_0001839c

CAD accumulation in lysosome [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002214
Super-classes obo:TXPO_0003367c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003369c
obo:TXPO_0000069op some obo:TXPO_0001260c
obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000069op some obo:TXPO_0003442c
obo:BFO_0000066op some obo:GO_0005764c
obo:RO_0000057op some obo:TXPO_0000081c

phospholipidosis (toxic course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002215
Super-classes obo:TXPO_0003382c
Restrictions obo:TXPO_0000004op only obo:TXPO_0002324c
obo:BFO_0000051op some obo:TXPO_0000925c
obo:BFO_0000051op some obo:TXPO_0001551c
obo:BFO_0000051op some obo:TXPO_0000930c
obo:BFO_0000051op some obo:TXPO_0000905c
obo:BFO_0000051op some obo:TXPO_0002324c
obo:BFO_0000051op some obo:TXPO_0000907c
obo:BFO_0000051op some obo:TXPO_0004117c
obo:BFO_0000051op some obo:TXPO_0000910c
Sub-classes obo:TXPO_0003369c
obo:TXPO_0001437c
obo:TXPO_0003452c
obo:TXPO_0004157c
obo:TXPO_0003359c

NRF2 activation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002216
Super-classes obo:TXPO_0000889c
obo:TXPO_0001283c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000904c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000012op some obo:TXPO_0002366c
obo:TXPO_0000069op some obo:TXPO_0002254c

negative regulation of phospholipid degradation [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002217
Super-classes obo:TXPO_0000905c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002098c
obo:TXPO_0000069op some obo:TXPO_0004032c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:BFO_0000051op some obo:TXPO_0000497c

negative regulation of phospholipase transcriptionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002218
Super-classes obo:GO_0045892c

hypofunction of phospholipase gene expression [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002219
Super-classes obo:TXPO_0001716c
obo:TXPO_0002295c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001448c
obo:TXPO_0000774op only obo:TXPO_0002215c

lysosomal dysfunction [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002220
Super-classes obo:TXPO_0002221c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

lysosomal dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002221
Super-classes obo:TXPO_0000438c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
Sub-classes obo:TXPO_0002220c

malfunctioning of cellular membrane [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002222
Super-classes obo:TXPO_0002198c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0000077c
obo:RO_0000057op some obo:TXPO_0004086c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000927c

positive regulation of phospholipid biosynthetic process [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002223
Super-classes obo:TXPO_0001710c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001708c
obo:TXPO_0000774op only obo:TXPO_0002215c

glutathione synthetic gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002224
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0002254c

phospholipid material transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002225
Super-classes obo:TXPO_0000111c

hyperfunction of phospholipid material transport [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002226
Super-classes obo:TXPO_0003440c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001315c
obo:TXPO_0000774op only obo:TXPO_0002215c

increase in intracellular calcium level [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002227
Super-classes obo:TXPO_0000354c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0004084c
obo:TXPO_0000069op some obo:TXPO_0002232c

toxicological balance L=L (maintining homeostasis at lower level)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002228
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some obo:TXPO_0001734c
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL72317C17c and obo:TXPO_0001746c and ub744bL72339C17c)
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL72317C17c and obo:TXPO_0001746c and ub744bL72339C17c)

increasing uptake amount of mitochondrial calcium ionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002229
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002233op some obo:CHEBI_39124c
obo:RO_0002339op some obo:GO_0005739c
obo:RO_0002338op some obo:GO_0005737c
Sub-classes obo:TXPO_0004267c
obo:TXPO_0002232c

hypofunction of ATP biosynthesis [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002230
Super-classes obo:TXPO_0001987c
obo:TXPO_0001722c
Restrictions obo:TXPO_0001868op some obo:TXPO_0004232c
obo:TXPO_0000069op some obo:TXPO_0000933c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001988c
obo:TXPO_0000069op some obo:TXPO_0004264c

release of calcium ion from lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002231
Super-classes obo:TXPO_0002588c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
obo:RO_0002234op some obo:CHEBI_39124c
Sub-classes obo:TXPO_0002240c

increasing uptake amount of mitochondrial calcium ion [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002232
Super-classes obo:TXPO_0001716c
obo:TXPO_0002229c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002233c
obo:RO_0000057op some obo:TXPO_0003477c
obo:TXPO_0000774op only obo:TXPO_0002215c

decreasing mitochondrial membrane potential [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002233
Super-classes obo:TXPO_0001716c
obo:TXPO_0001855c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000928c
obo:BFO_0000066op some obo:GO_0031966c
obo:TXPO_0000069op some obo:TXPO_0002234c

hypofunction of ATP biosynthesis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002234
Super-classes obo:TXPO_0001716c
obo:TXPO_0001722c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000927c
obo:TXPO_0000774op only obo:TXPO_0002215c

autolysisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002235
Super-classes obo:TXPO_0002570c
Sub-classes obo:TXPO_0002097c

stabilizing membrane structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002236
Super-classes obo:TXPO_0003733c
Sub-classes obo:TXPO_0002237c

stabilizing lysosomal membrane structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002237
Super-classes obo:TXPO_0002236c
Sub-classes obo:TXPO_0002238c

stabilizing lysosomal membrane structure [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002238
Super-classes obo:TXPO_0002237c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0002239c

negative regulation of apoptotic process [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002239
Description

Negative regulation of apoptotic process might be a defense process prevent the number of cells from decreasing too much.
Super-classes obo:GO_0043066c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002245c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003570c
obo:RO_0000057op some obo:TXPO_0002244c
obo:RO_0000057op some obo:TXPO_0003993c
obo:BFO_0000051op some obo:TXPO_0003406c
obo:BFO_0000051op some obo:TXPO_0003890c
obo:RO_0000057op some obo:TXPO_0003998c
obo:RO_0000057op some obo:TXPO_0003788c

release of calcium ion from lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002240
Super-classes obo:TXPO_0001716c
obo:TXPO_0002231c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0002227c

obesity [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002241
Super-classes ()
obo:TXPO_0001716c
obo:TXPO_0001286c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004158c
obo:TXPO_0000774op only obo:TXPO_0000949c
obo:BFO_0000051op some obo:TXPO_0004088c
obo:TXPO_0000069op some obo:TXPO_0001822c
obo:BFO_0000051op some obo:TXPO_0004111c
obo:RO_0000057op some obo:TXPO_0001142c

negative regulation of inflammatory response [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002242
Super-classes obo:TXPO_0002243c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0002290c
obo:TXPO_0000774op only obo:TXPO_0002215c

negative regulation of inflammatory responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002243
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0000192c
Sub-classes obo:TXPO_0002242c
obo:TXPO_0002430c
obo:TXPO_0003207c

Ang (mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002244
Super-classes obo:TXPO_0003278c
obo:TXPO_0001517c
Restrictions obo:TXPO_0000756op some obo:OBI_0000070c
obo:RO_0000087op some obo:TXPO_0002261c

tumor growth [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002245
Super-classes obo:TXPO_0001716c
obo:TXPO_0000766c
Restrictions obo:RO_0000057op some obo:TXPO_0003347c
obo:RO_0000057op some obo:TXPO_0002244c
obo:TXPO_0000774op only obo:TXPO_0002215c

DNA repair rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002246
Super-classes obo:TXPO_0001316c
Restrictions obo:TXPO_0000178op some obo:GO_0006281c

cell cycle regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002247
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0007049c
Sub-classes obo:TXPO_0002269c
obo:TXPO_0002270c

increasing phospholipid metabolitec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002248
Super-classes obo:TXPO_0000395c

Gadd45a - cell cycle arrest factor (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002249
Super-classes obo:TXPO_0001158c
Restrictions obo:RO_0000056op some obo:TXPO_0001547c
obo:RO_0000087op some obo:TXPO_0002247c
obo:RO_0000056op some obo:TXPO_0001489c
obo:RO_0000056op some obo:TXPO_0001850c
obo:TXPO_0000756op some obo:TXPO_0000489c

fibrosis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002250
Super-classes obo:TXPO_0003230c

Gadd45a - fibrosis inhibitor (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002251
Super-classes obo:TXPO_0001158c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000056op some obo:TXPO_0001850c
obo:RO_0000087op some obo:TXPO_0002250c

decreasing CAD in lysosomal membranes [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002252
Super-classes obo:TXPO_0002253c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

decreasing CAD in lysosomal membranesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002253
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0002252c

glutathione synthetic gene expression [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002254
Super-classes obo:TXPO_0002224c
obo:TXPO_0000889c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002392c
obo:TXPO_0000069op some obo:TXPO_0001933c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0000193c
obo:RO_0000057op some obo:TXPO_0002453c

positive regulation of phospholipid catabolic process [phopholipidosis - normal]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002255
Super-classes obo:TXPO_0001716c
obo:GO_0060697c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0002257c

hyperfunction of phospholipase gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002256
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0002257c

hyperfunction of phospholipase gene expression [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002257
Super-classes obo:TXPO_0001716c
obo:TXPO_0002256c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0003384c

keeping acidic environment in lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002258
Super-classes obo:TXPO_0001716c
obo:TXPO_0002259c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000066op some obo:GO_0005764c

keeping acidic environment in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002259
Super-classes obo:TXPO_0000474c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
Sub-classes obo:TXPO_0002258c

positive regulator of tumor growthc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002261
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:TXPO_0000766c

drug-metabolizing enzyme rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002262
Super-classes obo:CHEBI_52210c

increasing number of macrophage derived foam cell (niemann pick cell) [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002263
Super-classes obo:TXPO_0000918c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001462c

hepatic cirrhosis [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002264
Super-classes obo:TXPO_0001716c
obo:TXPO_0002202c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

inflammatory cytokine gene expression [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002265
Super-classes obo:TXPO_0002266c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0004104c
obo:BFO_0000051op some obo:TXPO_0003405c

inflammatory cytokine gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002266
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0003208c
obo:TXPO_0002830c
obo:TXPO_0000704c
obo:TXPO_0000639c
obo:TXPO_0000842c
obo:TXPO_0000211c
obo:TXPO_0002805c
obo:TXPO_0000191c
obo:TXPO_0002806c
obo:TXPO_0003043c
obo:TXPO_0002766c
obo:TXPO_0002265c
obo:TXPO_0003827c
obo:TXPO_0002811c
obo:TXPO_0000050c
obo:TXPO_0004270c
obo:TXPO_0002833c
obo:TXPO_0002843c

IL2RB - apotosis inhibitor (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002267
Super-classes obo:TXPO_0001143c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c
obo:RO_0000056op some obo:TXPO_0001488c
obo:RO_0000056op some obo:TXPO_0000833c
obo:TXPO_0000756op some obo:TXPO_0000795c

IL2RB - cell cycle progression promoting factor (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002268
Super-classes obo:TXPO_0001143c
Restrictions obo:RO_0000087op some obo:TXPO_0002269c
obo:RO_0000056op some obo:TXPO_0001488c
obo:RO_0000056op some obo:TXPO_0000833c
obo:TXPO_0000756op some ncicp:C15958c

positive regulator of cell cycle rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002269
Super-classes obo:TXPO_0002247c
Restrictions obo:RO_0002598op some obo:GO_0007049c

positive regulator of cell cycle arrest rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002270
Super-classes obo:TXPO_0002247c
Restrictions obo:RO_0002598op some obo:GO_0007050c

positive regulator of cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002271
Super-classes obo:TXPO_0003159c
Restrictions obo:RO_0002598op some obo:GO_0008283c
Sub-classes obo:TXPO_0002272c

positive regulator of tumor cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002272
Super-classes obo:TXPO_0002271c
obo:TXPO_0003534c
Restrictions obo:RO_0002598op some obo:TXPO_0000339c

maintaining phospholipid homeostasis [Phospholipidosis (latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002273
Super-classes obo:TXPO_0000951c
obo:GO_0055091c
Restrictions obo:TXPO_0001733op some obo:TXPO_0002076c
obo:TXPO_0000774op only obo:TXPO_0001964c

hyperfunction of biological defense functionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002274
Super-classes obo:TXPO_0002360c
Restrictions obo:BFO_0000051op some obo:TXPO_0002275c
Sub-classes obo:TXPO_0002277c

hyperfunction of cell survivalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002275
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:NCIT_C16407c
Sub-classes obo:TXPO_0000597c
obo:TXPO_0002533c
obo:TXPO_0002276c

hyperfunction of cell survival [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002276
Super-classes obo:TXPO_0001716c
obo:TXPO_0002275c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003547c
obo:BFO_0000051op some obo:TXPO_0002281c
obo:BFO_0000051op some obo:TXPO_0001489c
obo:BFO_0000051op some obo:TXPO_0001490c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0000921c

hyperfunction of biological defense function [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002277
Super-classes obo:TXPO_0001716c
obo:TXPO_0002274c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

hyperfunction of removing [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002278
Super-classes obo:TXPO_0002279c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

hyperfunction of removingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002279
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000458c
Sub-classes obo:TXPO_0002278c
obo:TXPO_0002701c
obo:TXPO_0001483c
obo:TXPO_0000884c

AKT - apotosis inhibitor (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002280
Super-classes obo:TXPO_0001799c
Restrictions obo:TXPO_0002260op some obo:IMR_0000250c
obo:RO_0000087op some obo:CHEBI_68494c

carcinogenesis [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002281
Super-classes obo:NCIT_C18078c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002276c
obo:TXPO_0000069op some obo:TXPO_0001491c
obo:TXPO_0000069op some obo:TXPO_0002245c
obo:TXPO_0000774op only obo:TXPO_0002215c

converting typec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002282
Super-classes obo:TXPO_0000392c
Sub-classes obo:GO_0030154c
obo:TXPO_0002567c
obo:TXPO_0002703c
obo:GO_0010467c

lipasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002283
Description

related molecular function: GO:0016298
Super-classes obo:TXPO_0003663c
Sub-classes obo:TXPO_0002307c
obo:PR_000009897c
obo:TXPO_0003671c

immune responsor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002284
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0006955c

glutathione depletion dependent gene [mouse]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002285
Super-classes obo:TXPO_0001915c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10090c
Sub-classes obo:TXPO_0002453c
obo:TXPO_0003389c
obo:TXPO_0003519c
obo:TXPO_0002291c
obo:TXPO_0000847c

cytokine production inducerc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002286
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002598op some obo:GO_0001816c
Sub-classes obo:TXPO_0002287c

IL-2 production inducerc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002287
Super-classes obo:TXPO_0002286c
Restrictions obo:RO_0002598op some obo:GO_0032623c

IL2 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002288
Super-classes obo:TXPO_0003213c
obo:TXPO_1000201c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c
obo:TXPO_0002260op some obo:IMR_0000007c
Sub-classes obo:TXPO_0003427c
obo:TXPO_0003426c
obo:TXPO_0003429c
obo:TXPO_0003428c

inhibitor of immune responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002289
Super-classes obo:TXPO_0003726c

PLA2G5 - anntiinflammation factor (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002290
Super-classes obo:TXPO_0001142c
Restrictions obo:RO_0000087op some obo:TXPO_0002289c
obo:TXPO_0002260op some obo:IMR_0000283c
obo:TXPO_0000043op some obo:CL_0000136c
obo:TXPO_0000756op some ncicp:C15958c

Gstm3 (mouse)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002291
Super-classes obo:TXPO_0002285c
obo:TXPO_1000180c

protein tyrosine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002292
Description

related molecular function GO:0004713
Super-classes obo:TXPO_0001865c
Sub-classes obo:TXPO_0001054c
obo:TXPO_0000823c

phospholipid metabolism balance [Phospholipidosis (latent) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002293
Super-classes obo:TXPO_0000946c
obo:TXPO_0001434c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002273c
obo:TXPO_0000774op only obo:TXPO_0001964c
obo:TXPO_0001733op some obo:TXPO_0002076c

NFKB1 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002294
Super-classes obo:TXPO_1000251c
obo:TXPO_0003213c
Restrictions obo:TXPO_0002260op some obo:IMR_0000382c
obo:RO_0000087op some obo:TXPO_0000330c

hypofunction of phospholipase gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002295
Super-classes obo:TXPO_0002356c
Sub-classes obo:TXPO_0002219c

di-22:6-BMP [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002296
Super-classes obo:CHEBI_60815c
obo:TXPO_0001849c
Restrictions obo:TXPO_0002260op some obo:CHEBI_60815c

negative regulation of endocytosis [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002297
Super-classes obo:TXPO_0001716c
obo:GO_0045806c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000911c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0000717c

JNK (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002298
Super-classes obo:TXPO_1000216c
obo:TXPO_0002045c
obo:IMR_0000225c

creatine kinasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002299
Description

related molecular function GO:0004111
Super-classes obo:TXPO_0001515c

GCLM (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002300
Super-classes obo:TXPO_0002331c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:TXPO_0002394c

increasing demand for response to mitochondrial oxidative stressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002301
Super-classes obo:TXPO_0000102c
Restrictions obo:BFO_0000066op some obo:TXPO_0000047c
Sub-classes obo:TXPO_0001029c
obo:TXPO_0001201c
obo:TXPO_0001186c

Glutathione conjugation (supply) - function demand imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002302
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0002582c
obo:TXPO_0001191c

hyperfunction of biological repair functionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002303
Super-classes obo:TXPO_0000435c

hypofunction of xenobiotics conjugate excretionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002304
Super-classes obo:TXPO_0001342c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000631c

decreasing excretion quantity of the bile acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002305
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0001190c

lysophosphatidic acid acyltransferasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002306
Description

related molecular function GO:0042171
Super-classes obo:TXPO_0000606c

triglyceride lipasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002307
Description

related molecular finction GO:0004806
Super-classes obo:TXPO_0002283c

phospholipid metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002308
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0001293c
obo:TXPO_0002324c
obo:TXPO_0001295c

constitutive androstane receptor activation by phenobarbital [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002309
Super-classes obo:TXPO_0000935c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003258c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003858c
obo:TXPO_0001868op some obo:TXPO_0001524c
Sub-classes obo:TXPO_0003875c
obo:TXPO_0000967c

dysfunction of glycerophospholipid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002310
Super-classes obo:TXPO_0001447c
Restrictions obo:TXPO_0000716op some obo:GO_0046475c
Sub-classes obo:TXPO_0002315c
obo:TXPO_0002314c
obo:TXPO_0002313c
obo:TXPO_0002317c
obo:TXPO_0002316c
obo:TXPO_0002312c

hyperfunction of increasing the amount of phenobarbital (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002311
Super-classes obo:TXPO_0001840c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003856c
obo:TXPO_0000716op some obo:TXPO_0001637c

dysfunction ofphosphatidylinositol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002312
Super-classes obo:TXPO_0002310c

dysfunction of phosphatidylethanolamine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002313
Super-classes obo:TXPO_0002310c
Restrictions obo:BFO_0000051op some obo:TXPO_0001545c

dysfunction of phosphatidylglycerol degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002314
Super-classes obo:TXPO_0002310c

dysfunction of phosphatidylcholine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002315
Super-classes obo:TXPO_0002310c

dysfunction of phosphatidyl-L-serine degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002316
Super-classes obo:TXPO_0002310c

dysfunction of phosphatidic acid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002317
Super-classes obo:TXPO_0002310c

hyperfunction of cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002318
Super-classes obo:TXPO_0000473c
Restrictions obo:TXPO_0001502op some obo:GO_0008283c
Sub-classes obo:TXPO_0002321c

carcinogenesis [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002319
Super-classes ()
obo:NCIT_C18078c
obo:TXPO_0001728c
Restrictions obo:BFO_0000066op some obo:NCBITaxon_9989c
obo:TXPO_0000069op some obo:TXPO_0001013c
obo:TXPO_0000069op some obo:TXPO_0000597c
obo:TXPO_0000069op some obo:TXPO_0001030c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0001028c
obo:BFO_0000066op some obo:UBERON_0002107c

hepatocyte proliferation (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002320
Super-classes obo:TXPO_0000970c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002319c
obo:TXPO_0000069op some obo:TXPO_0000597c
obo:TXPO_0000774op only obo:TXPO_0001432c

hyperfunction of hepatocyte proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002321
Super-classes obo:TXPO_0002318c
Restrictions obo:TXPO_0001502op some obo:GO_0072574c
Sub-classes obo:TXPO_0001838c

negative regulation of apoptotic process (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002322
Super-classes obo:GO_0043066c
obo:TXPO_0000965c
Restrictions obo:RO_0000057op some obo:TXPO_0000784c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0001868op some obo:TXPO_0004102c
obo:TXPO_0000069op some obo:TXPO_0003904c
obo:RO_0000057op some obo:TXPO_0000976c
obo:RO_0000057op some obo:TXPO_0001073c
obo:RO_0000057op some obo:TXPO_0000975c
obo:TXPO_0000069op some obo:TXPO_0002320c
obo:TXPO_0000069op some obo:TXPO_0000597c

negative regulation of autophagy (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002323
Super-classes obo:GO_0010507c
obo:TXPO_0001018c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001677c
obo:TXPO_0000774op only obo:TXPO_0001432c

phospholipid metabolism imbalance [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002324
Super-classes obo:TXPO_0000946c
obo:TXPO_0002308c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000910c
obo:TXPO_0000716op some obo:TXPO_0001435c
obo:TXPO_0001733op some obo:TXPO_0003992c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0001777c
obo:TXPO_0001778c
obo:TXPO_0003372c
obo:TXPO_0001776c
obo:TXPO_0004163c

accumulation of drug in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002325
Super-classes obo:TXPO_0000169c
Restrictions obo:BFO_0000066op only obo:CL_0000182c
Sub-classes obo:TXPO_0000181c
obo:TXPO_0003829c

increasing demand for NAPQI metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002326
Super-classes obo:TXPO_0000789c

toxicological imbalance VL(defense)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002327
Super-classes obo:TXPO_0003992c
Restrictions obo:BFO_0000051op some obo:TXPO_0001735c
obo:BFO_0000051op some (obo:TXPO_0001736c and ub744bL73705C17c)

very low levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002328
Super-classes obo:TXPO_0004208c

hepatic fibrosis [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002329
Description

under construction
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0003745c
obo:BFO_0000051op some obo:TXPO_0003782c
obo:BFO_0000051op some obo:TXPO_0003755c
obo:BFO_0000051op some obo:TXPO_0003759c
obo:BFO_0000051op some obo:TXPO_0003746c
obo:BFO_0000051op some obo:TXPO_0001721c
obo:BFO_0000051op some obo:TXPO_0003783c
obo:BFO_0000051op some obo:TXPO_0003761c
obo:BFO_0000051op some obo:TXPO_0002152c
obo:BFO_0000051op some obo:TXPO_0003743c
obo:BFO_0000051op some obo:TXPO_0003781c
obo:BFO_0000051op some obo:TXPO_0003757c
obo:BFO_0000051op some obo:TXPO_0003779c
obo:BFO_0000051op some obo:TXPO_0003800c
obo:BFO_0000051op some obo:TXPO_0000224c
obo:BFO_0000051op some obo:TXPO_0003802c
Sub-classes obo:TXPO_0003804c
obo:TXPO_0003803c

hypofunction of drug metabolism phase IIc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002330
Super-classes obo:TXPO_0002190c
Sub-classes obo:TXPO_0001189c

glutamate-cysteine ligase modifier subunitc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002331
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002730c
Sub-classes obo:TXPO_0002300c

hyperfunction of drug metabolizing enzyme gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002332
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0001180c
obo:TXPO_0002051c

increasing number of dead cells in liver [Oxidative stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002333
Super-classes obo:TXPO_0001730c
obo:TXPO_0000341c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000677c

cel cycle related gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002334
Super-classes obo:GO_0010467c

hyperfunction of fatty acid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002335
Super-classes obo:TXPO_0002346c
Restrictions obo:TXPO_0001502op some obo:GO_0006633c
Sub-classes obo:TXPO_0000890c

lipid metabolism imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002336
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0000893c

hyperfunction of lipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002337
Super-classes obo:TXPO_0002346c
Restrictions obo:TXPO_0001502op some obo:GO_0008610c
Sub-classes obo:TXPO_0000898c

hyperfunction of lipid synthetic gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002338
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0000899c

lipid vacuole organizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002339
Super-classes obo:GO_0007033c

liver carcinogenesis dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002340
Super-classes obo:TXPO_0001715c
Sub-classes obo:TXPO_0004402c
obo:TXPO_0004661c
obo:TXPO_0004413c
obo:TXPO_0004695c
obo:TXPO_0004597c
obo:TXPO_0004793c
obo:TXPO_0004595c
obo:TXPO_0004787c
obo:TXPO_0004557c
obo:TXPO_0004908c
obo:TXPO_0004543c
obo:TXPO_0004489c
obo:TXPO_0004394c
obo:TXPO_0004298c
obo:TXPO_0004949c
obo:TXPO_0004419c
obo:TXPO_0004874c
obo:TXPO_0004800c
obo:TXPO_0004881c
obo:TXPO_0004728c
obo:TXPO_0004656c
obo:TXPO_0005022c
obo:TXPO_0004487c
obo:TXPO_0004609c
obo:TXPO_0004422c
obo:TXPO_0004633c
obo:TXPO_0004794c
obo:TXPO_0004783c
obo:TXPO_0005026c
obo:TXPO_0004659c
obo:TXPO_0004779c
obo:TXPO_0004501c
obo:TXPO_0004508c
obo:TXPO_0004847c
obo:TXPO_0004276c
obo:TXPO_0004492c
obo:TXPO_0004841c
obo:TXPO_0004421c
obo:TXPO_0004825c
obo:TXPO_0004400c
obo:TXPO_0005051c
obo:TXPO_0004570c
obo:TXPO_0004598c
obo:TXPO_0004882c
obo:TXPO_0004464c
obo:TXPO_0004396c
obo:TXPO_0004616c
obo:TXPO_0004457c
obo:TXPO_0004617c
obo:TXPO_0004412c
obo:TXPO_0004828c
obo:TXPO_0004407c
obo:TXPO_0004757c
obo:TXPO_0004664c
obo:TXPO_0004309c
obo:TXPO_0004627c
obo:TXPO_0004546c
obo:TXPO_0004901c
obo:TXPO_0004600c
obo:TXPO_0005036c
obo:TXPO_0004410c
obo:TXPO_0004686c
obo:TXPO_0005014c
obo:TXPO_0004588c
obo:TXPO_0004417c
obo:TXPO_0004655c
obo:TXPO_0004738c
obo:TXPO_0004476c
obo:TXPO_0005032c
obo:TXPO_0004816c
obo:TXPO_0004506c
obo:TXPO_0004803c
obo:TXPO_0004420c
obo:TXPO_0004497c
obo:TXPO_0004517c
obo:TXPO_0004574c
obo:TXPO_0004447c
obo:TXPO_0004582c
obo:TXPO_0004392c
obo:TXPO_0004587c
obo:TXPO_0004591c
obo:TXPO_0004652c
obo:TXPO_0004434c
obo:TXPO_0004391c
obo:TXPO_0004809c
obo:TXPO_0004745c
obo:TXPO_0004479c
obo:TXPO_0005035c
obo:TXPO_0004854c
obo:TXPO_0004844c
obo:TXPO_0004845c
obo:TXPO_0005038c
obo:TXPO_0004630c
obo:TXPO_0004431c
obo:TXPO_0004791c
obo:TXPO_0004596c
obo:TXPO_0004432c
obo:TXPO_0004773c
obo:TXPO_0004923c
obo:TXPO_0004640c
obo:TXPO_0004693c
obo:TXPO_0004589c
obo:TXPO_0004650c
obo:TXPO_0004395c
obo:TXPO_0004586c
obo:TXPO_0004453c
obo:TXPO_0004929c
obo:TXPO_0004577c
obo:TXPO_0004669c
obo:TXPO_0004759c
obo:TXPO_0004555c
obo:TXPO_0004673c
obo:TXPO_0004542c
obo:TXPO_0004525c
obo:TXPO_0004477c
obo:TXPO_0004592c
obo:TXPO_0004541c
obo:TXPO_0004731c
obo:TXPO_0004483c
obo:TXPO_0004634c
obo:TXPO_0004566c
obo:TXPO_0004299c
obo:TXPO_0004404c
obo:TXPO_0004919c
obo:TXPO_0004289c
obo:TXPO_0004590c
obo:TXPO_0004409c
obo:TXPO_0004438c
obo:TXPO_0004452c
obo:TXPO_0004418c
obo:TXPO_0004593c
obo:TXPO_0004703c
obo:TXPO_0005005c
obo:TXPO_0004427c
obo:TXPO_0004735c
obo:TXPO_0004518c
obo:TXPO_0004683c
obo:TXPO_0005019c
obo:TXPO_0004526c
obo:TXPO_0004522c
obo:TXPO_0004403c
obo:TXPO_0004952c
obo:TXPO_0004776c
obo:TXPO_0004514c
obo:TXPO_0004646c
obo:TXPO_0004529c
obo:TXPO_0004996c
obo:TXPO_0004755c
obo:TXPO_0004883c
obo:TXPO_0004643c
obo:TXPO_0004698c
obo:TXPO_0004636c
obo:TXPO_0004505c
obo:TXPO_0004899c
obo:TXPO_0004426c
obo:TXPO_0005017c
obo:TXPO_0004837c
obo:TXPO_0005010c
obo:TXPO_0004536c
obo:TXPO_0004963c
obo:TXPO_0004311c
obo:TXPO_0004753c
obo:TXPO_0004749c
obo:TXPO_0004470c
obo:TXPO_0004480c
obo:TXPO_0004585c
obo:TXPO_0004414c
obo:TXPO_0004679c
obo:TXPO_0004603c
obo:TXPO_0004579c
obo:TXPO_0004512c
obo:TXPO_0004538c
obo:TXPO_0004507c
obo:TXPO_0004758c
obo:TXPO_0004681c
obo:TXPO_0004689c
obo:TXPO_0004789c
obo:TXPO_0004468c
obo:TXPO_0004834c
obo:TXPO_0004764c
obo:TXPO_0004459c
obo:TXPO_0004491c
obo:TXPO_0004818c
obo:TXPO_0004625c
obo:TXPO_0004429c

leaking proton ionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002341
Super-classes obo:TXPO_0001699c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0002038c

negative regulation of respiratory electron transport chainc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002342
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0022904c
Sub-classes obo:GO_1902957c
obo:TXPO_0004081c
obo:TXPO_0001748c
obo:TXPO_0001989c
obo:TXPO_0004099c

changing iron ion concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002343
Super-classes obo:TXPO_0002438c
Sub-classes obo:TXPO_0002009c

hyperfunction of mitochondrial fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002344
Super-classes obo:TXPO_0000095c
Sub-classes obo:TXPO_0000146c
obo:TXPO_0003969c

hyperfunction of gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002345
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0000716op some obo:GO_0010467c
Sub-classes obo:TXPO_0000398c
obo:TXPO_0002338c
obo:TXPO_0001215c
obo:TXPO_0002332c
obo:TXPO_0001726c
obo:TXPO_0001378c
obo:TXPO_0003257c
obo:TXPO_0000658c
obo:TXPO_0002256c

hyperfunction of biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002346
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0009058c
Sub-classes obo:TXPO_0004004c
obo:TXPO_0004515c
obo:TXPO_0001410c
obo:TXPO_0002337c
obo:TXPO_0001367c
obo:TXPO_0002335c
obo:TXPO_0004942c

hyperfunction of drug metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002347
Super-classes obo:TXPO_0002352c
Restrictions obo:TXPO_0001502op some obo:GO_0017144c
Sub-classes obo:TXPO_0000443c
obo:TXPO_0002049c
obo:TXPO_0001236c

decreasing bile flow in bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002348
Super-classes obo:TXPO_0002673c
Sub-classes obo:TXPO_0002657c

hyperfunction of decompoingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002349
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000343c
Sub-classes obo:TXPO_0001430c
obo:TXPO_0000100c

peroxisome proliferatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002350
Super-classes obo:TXPO_0000625c

hyperfunction of transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002351
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0006810c
Sub-classes obo:TXPO_0003259c
obo:TXPO_0001415c
obo:TXPO_0000478c
obo:TXPO_0003440c
obo:TXPO_0000480c
obo:TXPO_0002708c
obo:TXPO_0002052c
obo:TXPO_0003481c

hyperfunction of metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002352
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0008152c
Sub-classes obo:TXPO_0002347c

positive regulator role of feeding behaviorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002353
Super-classes obo:TXPO_0003230c

hypofunction of metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002354
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0008152c
Sub-classes obo:TXPO_0001375c
obo:TXPO_0002190c
obo:TXPO_0001326c
obo:TXPO_0001324c
obo:TXPO_0001323c
obo:TXPO_0001325c

hypofunction of removingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002355
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000458c
Sub-classes obo:TXPO_0001342c

hypofunction of transcription, DNA-templatedc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002356
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0006351c
Sub-classes obo:TXPO_0002295c
obo:TXPO_0001860c
obo:TXPO_0004820c
obo:TXPO_0004768c

PPARalpha inactivation [alcoholic fatty liver]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002357
Super-classes obo:TXPO_0001571c
obo:TXPO_0001720c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001634c
obo:RO_0000057op some obo:TXPO_0002501c
obo:TXPO_0000774op only obo:TXPO_0001155c

lipid metabolic regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002358
Super-classes obo:TXPO_0004023c
Restrictions obo:RO_0002596op some obo:GO_0006629c
Sub-classes obo:TXPO_0002196c
obo:TXPO_0003647c

hyperfunction of moving drug to the inside of liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002359
Super-classes obo:TXPO_0001681c
Restrictions obo:TXPO_0001502op some obo:TXPO_0000312c
Sub-classes obo:TXPO_0002600c

hyperfunction of defensive functionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002360
Super-classes obo:TXPO_0000435c
Sub-classes obo:TXPO_0002274c

mitochondrial dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002361
Super-classes obo:TXPO_0000438c
Sub-classes obo:TXPO_0000252c
obo:TXPO_0000042c
obo:TXPO_0000933c
obo:TXPO_0003851c
obo:TXPO_0001202c
obo:TXPO_0004996c

phospholipid biosynthetic positive regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002362
Super-classes obo:TXPO_0003647c
Restrictions obo:RO_0002598op some obo:GO_0008654c

cell survival [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002363
Super-classes obo:TXPO_0000889c
obo:NCIT_C16407c
Restrictions obo:RO_0000057op some obo:TXPO_0000661c
obo:TXPO_0000774op only obo:TXPO_0000501c

increasing drug metabolitec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002364
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0002099c
obo:TXPO_0001178c
obo:TXPO_0003756c
obo:TXPO_0000325c

GCLC (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002365
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002729c

dissociation of Nrf2-Keap1 complex [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002366
Super-classes obo:TXPO_0002737c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0002216c

activation of thioredoxin pathway [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002367
Super-classes obo:TXPO_0000889c
obo:TXPO_0000507c
Restrictions obo:RO_0000057op some obo:TXPO_0001930c
obo:TXPO_0000069op some obo:TXPO_0002368c
obo:TXPO_0000774op only obo:TXPO_0000501c

hyperfunction of anti-oxidative stress [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002368
Super-classes obo:TXPO_0000889c
obo:TXPO_0002063c
Restrictions obo:RO_0000057op some obo:TXPO_0001936c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0001938c
obo:RO_0000057op some obo:TXPO_0001934c
obo:TXPO_0000069op some obo:TXPO_0003177c
obo:RO_0000057op some obo:TXPO_0001930c

p53 signaling (primitive) [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002369
Super-classes obo:TXPO_0000001c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0002376c
obo:RO_0000057op some obo:TXPO_0001935c
obo:TXPO_0000069op some obo:TXPO_0002370c
obo:RO_0000057op some obo:TXPO_0001932c

caspase signaling (primitive) [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002370
Super-classes obo:TXPO_0000889c
obo:TXPO_0000444c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0002371c

apoptotic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002371
Super-classes obo:TXPO_0000889c
obo:GO_0006915c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0001932c
obo:TXPO_0000069op some obo:TXPO_0002372c

increasing number of dead cells in liver [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002372
Super-classes obo:TXPO_0000341c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0002373c

liver dysfunction [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002373
Super-classes obo:TXPO_0000889c
obo:TXPO_0000203c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0000501c

p450 activatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002374
Super-classes obo:TXPO_0003714c
Restrictions obo:RO_0002598op some obo:TXPO_0001758c

JNK signaling (primitive) [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002375
Super-classes obo:TXPO_0000769c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002369c
obo:TXPO_0000069op some obo:TXPO_0001207c
obo:RO_0000057op some obo:TXPO_0002298c
obo:RO_0000057op some obo:TXPO_0000000c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0001948c

regulation of cell cycle [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002376
Super-classes obo:GO_0051726c
obo:TXPO_0000889c
Restrictions obo:RO_0000057op some obo:TXPO_0001945c
obo:TXPO_0000774op only obo:TXPO_0000501c

Keap1 oxidative modification by electrophilesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002377
Super-classes obo:GO_0055114c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0002404c
Sub-classes obo:TXPO_0002407c

changing activity of eIF2a by PERK [ER stress PERK - eIF2A pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002378
Super-classes obo:TXPO_0003736c
obo:TXPO_0000696c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0000700c
Sub-classes obo:TXPO_0002518c
obo:TXPO_0002852c
obo:TXPO_0003001c
obo:TXPO_0002517c
obo:TXPO_0002506c

NADPH regeneration [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002379
Super-classes obo:TXPO_0000889c
obo:GO_0006740c
Restrictions obo:RO_0000057op some obo:TXPO_0000135c
obo:TXPO_0000069op some obo:TXPO_0002368c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0001936c
obo:RO_0000057op some obo:TXPO_0001917c
obo:TXPO_0000069op some obo:TXPO_0001194c

Keap1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002380
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0000877c and ub744bL74419C17c)
Sub-classes obo:TXPO_0002404c

abnormality of membrane (severe) [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002381
Super-classes obo:TXPO_0001727c
obo:TXPO_0001755c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002387c

TP53 - cell cycle regulation factor (canonical)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002382
Super-classes obo:TXPO_0000843c
Restrictions obo:RO_0000087op some obo:TXPO_0002247c

eosinogranular degeneration dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002383
Super-classes obo:TXPO_0000835c
Sub-classes obo:TXPO_0000121c
obo:TXPO_0000122c

chaperon production [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002384
Super-classes obo:TXPO_0000384c
obo:TXPO_0001717c
Restrictions obo:RO_0002234op some obo:TXPO_0002164c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0000561c
obo:TXPO_0000069op some obo:TXPO_0002716c
obo:RO_0002234op some obo:TXPO_0000783c
obo:RO_0002234op some obo:TXPO_0002677c
obo:RO_0002234op some obo:TXPO_0000828c
obo:RO_0002234op some obo:TXPO_0000801c

GRP78 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002385
Super-classes obo:TXPO_0000871c
obo:TXPO_0001002c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
Sub-classes obo:TXPO_0002622c
obo:TXPO_0002540c
obo:TXPO_0003489c
obo:TXPO_0000451c
obo:TXPO_0003550c
obo:TXPO_0002677c
obo:TXPO_0002621c
obo:TXPO_0002619c

OCT1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002386
Description

FXR inhibits OCT1 via SHP1
Super-classes obo:TXPO_0002647c
Restrictions obo:TXPO_0002260op some ncicp:C21204c

necrosis [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002387
Super-classes obo:GO_0070265c
obo:TXPO_0000008c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0002389c

apoptotic DNA fragmentation [Apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002388
Super-classes obo:GO_0006309c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000324c

increasing cell volume [Necrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002389
Super-classes obo:TXPO_0001727c
obo:TXPO_0000142c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0001449c

hypoxia [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002390
Super-classes obo:TXPO_0001727c
obo:MP_0005039c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:RO_0000057op some obo:TXPO_0000645c
obo:TXPO_0000069op some obo:TXPO_0002129c
obo:TXPO_0000069op some obo:TXPO_0000453c

fatty acid homeostasis imbalance in peroxisome (severe) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002391
Super-classes obo:TXPO_0002158c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0001025c

NRF2 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002392
Super-classes obo:TXPO_0002045c
obo:TXPO_0002527c
Restrictions obo:RO_0000087op some obo:TXPO_0003645c
Sub-classes obo:TXPO_0000855c
obo:TXPO_0000850c

refolding gene expression by ATF6 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002393
Super-classes obo:TXPO_0003736c
obo:TXPO_0002521c
Restrictions obo:RO_0002234op some obo:TXPO_0003053c
obo:TXPO_0001868op some obo:TXPO_0002899c
obo:RO_0002234op some obo:TXPO_0003049c
obo:TXPO_0000069op some obo:TXPO_0002384c
obo:RO_0002234op some obo:TXPO_0003050c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0002677c
obo:RO_0002234op some obo:TXPO_0002898c
obo:RO_0002234op some obo:TXPO_0003034c

glutathione biosynthetic limiting enzyme agent rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002394
Super-classes obo:TXPO_0003654c
Restrictions obo:RO_0002596op some obo:GO_0006750c

growth factor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002395
Description

Extracellular polypeptide signal molecule that can stimulate a cell grow or proliferate. Examples are EGF and PDGF. Most growth factors also have other actions.
Super-classes obo:TXPO_0003705c

glutathione expression positive regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002396
Super-classes obo:TXPO_0003650c

cell death inducerc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002397
Super-classes obo:TXPO_0002406c
Restrictions obo:RO_0002598op some obo:GO_0008219c

CDK5R1(mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002398
Super-classes obo:TXPO_0003241c

p53 inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002399
Super-classes obo:CHEBI_23924c
Restrictions obo:RO_0002599op some obo:TXPO_0001213c

glutathione biosynthetic promoting agentc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002400
Super-classes obo:TXPO_0003654c
Restrictions obo:RO_0002598op some obo:GO_0006750c
Sub-classes obo:TXPO_0002402c

second messengerc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002401
Super-classes obo:CHEBI_33280c

reduced glutathione biosynthetic promoting agentc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002402
Super-classes obo:TXPO_0002400c

release of cytochrome c from mitochondria [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002403
Super-classes obo:TXPO_0001727c
obo:GO_0001836c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0003737c

Keap1 inactivation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002404
Super-classes obo:TXPO_0000889c
obo:TXPO_0002380c
Restrictions obo:RO_0000057op some obo:TXPO_0001172c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0002216c
obo:TXPO_0000012op some obo:TXPO_0002407c
obo:BFO_0000051op some obo:TXPO_0002431c

BIP-stress sensor complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002405
Super-classes obo:TXPO_0002107c
Restrictions obo:RO_0002180op some obo:TXPO_0002385c
Sub-classes obo:TXPO_0002108c

cell death modulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002406
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0008219c
Sub-classes obo:TXPO_0000832c
obo:TXPO_0002397c

Keap1 modification by electrophiles [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002407
Super-classes obo:TXPO_0000889c
obo:TXPO_0002377c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0001868op some obo:TXPO_0000974c
obo:TXPO_0000069op some obo:TXPO_0002404c

PLA2G5 (human)(canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002408
Super-classes obo:TXPO_0003213c
obo:TXPO_1000283c
Restrictions obo:RO_0000056op some obo:GO_0034638c
obo:TXPO_0000819op some obo:OGG_3000005322c
obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0000756op some obo:TXPO_0000795c
obo:RO_0000087op some obo:TXPO_0002289c
obo:TXPO_0002260op some obo:IMR_0000283c

electrophiles formation [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002409
Description

A number of xenobiotics exert a toxic effect theough their metabolites. Electrophiles are molecules that contain an electron-deficient atom with a partial or full positive charge that can react by sharing electron pairs with electron rich atoms in nucleophiles. Electrophilic toxicants generally are detoxificated by conjugation of with the nucleophile, glutathione. This reaction can be facilitated by glutathione S-trasferases.
Super-classes obo:TXPO_0000212c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000678c
obo:TXPO_0000069op some obo:TXPO_0003344c

GRP94 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002410
Super-classes obo:TXPO_1000171c
obo:TXPO_0000871c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
Sub-classes obo:TXPO_0003734c
obo:TXPO_0003049c

PKCΕ (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002411
Super-classes obo:TXPO_1000280c
obo:TXPO_0000871c

PERK signaling to eIF2a [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002412
Super-classes obo:TXPO_0001717c
obo:TXPO_0002449c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002518c
obo:BFO_0000051op some obo:TXPO_0002516c

strength (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002413
Super-classes obo:TXPO_0000305c

mass attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002414
Super-classes obo:TXPO_0000305c

length attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002415
Super-classes obo:TXPO_0000305c

volume attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002416
Super-classes obo:TXPO_0000305c

temperature attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002417
Super-classes obo:TXPO_0000305c

pressure attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002418
Super-classes obo:TXPO_0000305c

force attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002419
Super-classes obo:TXPO_0000305c
Sub-classes obo:TXPO_0000307c

electric potential attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002420
Super-classes obo:TXPO_0000305c
Sub-classes obo:TXPO_0002421c

membrane potential attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002421
Super-classes obo:TXPO_0002420c

hydrophilicity attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002422
Super-classes obo:TXPO_0000305c

hydrophobicity attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002423
Super-classes obo:TXPO_0000305c

age attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002424
Super-classes obo:TXPO_0001536c

biological sex (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002425
Super-classes obo:TXPO_0000305c

biological sex valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002426
Super-classes obo:TXPO_0000277c
Sub-classes obo:TXPO_0002427c
obo:TXPO_0002428c

female valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002427
Super-classes obo:TXPO_0002426c

male valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002428
Super-classes obo:TXPO_0002426c

activation (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002429
Super-classes obo:TXPO_0000305c

negative regulation of inflammatory response [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002430
Super-classes obo:TXPO_0002243c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

autophagy dependent Keap1 catabolic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002431
Super-classes obo:TXPO_0002445c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

proteasome-mediated ubiquitin-dependent NRF2 catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002432
Super-classes obo:GO_0043161c
Sub-classes obo:TXPO_0002434c

gene expression by ATF4c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002433
Super-classes obo:TXPO_0000375c
Sub-classes obo:TXPO_0000698c

proteasome-mediated NRF2 degradation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002434
Super-classes obo:TXPO_0000889c
obo:TXPO_0002432c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

pancreatic beta cell damage [Type I Diabetes mellitus]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002435
Super-classes obo:TXPO_0003342c
obo:TXPO_0002182c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002437c
obo:TXPO_0000774op only obo:TXPO_0002671c

dysfunction of dysfunction of insulin secretionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002436
Super-classes obo:TXPO_0000438c
Sub-classes obo:TXPO_0002437c

dysfunction of insulin secretion [Type I Diabetes mellitus]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002437
Super-classes obo:TXPO_0003342c
obo:TXPO_0002436c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003577c
obo:TXPO_0000774op only obo:TXPO_0002671c
obo:TXPO_0001868op some obo:CL_0000169c

changing concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002438
Super-classes obo:TXPO_0000415c
Restrictions obo:TXPO_0000531op some obo:PATO_0001159c
Sub-classes obo:TXPO_0003007c
obo:TXPO_0000588c
obo:TXPO_0002343c
obo:TXPO_0000671c
obo:TXPO_0000352c

decreasing blood glucose level in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002439
Super-classes obo:TXPO_0000671c

PERK signaling to eIF2a [ER stress apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002440
Super-classes obo:TXPO_0002449c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002515c
obo:TXPO_0000069op some obo:TXPO_0002721c
obo:BFO_0000051op some obo:TXPO_0002517c

negative regulation of proteasomal ubiquitin-dependent protein catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002441
Super-classes obo:GO_1901799c
Restrictions obo:RO_0002212op some obo:GO_0043161c
Sub-classes obo:TXPO_0002442c

negative regulation of proteasomal ubiquitin-dependent NRF2 catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002442
Super-classes obo:TXPO_0002441c
Restrictions obo:RO_0002212op some obo:TXPO_0002432c

overeating [Type II Diabetes mellitus]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002443
Super-classes obo:TXPO_0003342c
obo:TXPO_0001541c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003042c
obo:TXPO_0000069op some obo:TXPO_0003581c

increasing insulin demandc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002444
Super-classes obo:TXPO_0000633c

autophagy dependent Keap1 catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002445
Super-classes obo:GO_0006914c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
Sub-classes obo:TXPO_0002431c

fatty acid homeostasis imbalance in peroxisomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002446
Super-classes obo:TXPO_0002133c
obo:TXPO_0003488c
Sub-classes obo:TXPO_0002158c

receiving abnormal protein signal by ATF6 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002447
Super-classes obo:TXPO_0003736c
obo:TXPO_0002554c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002550c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002900c
obo:TXPO_0000012op some obo:TXPO_0002904c

regulation of beta oxidation related gene expression (severe) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002448
Super-classes obo:TXPO_0000119c
obo:TXPO_0000118c
Restrictions obo:RO_0000057op some obo:TXPO_0001058c
obo:RO_0000057op some obo:TXPO_0001057c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:RO_0000057op some obo:TXPO_0001051c
obo:RO_0000057op some obo:TXPO_0001069c
obo:RO_0000057op some obo:TXPO_0001055c
obo:TXPO_0000069op some obo:TXPO_0000146c
obo:RO_0000057op some obo:TXPO_0002017c
obo:BFO_0000051op some obo:TXPO_0000128c
obo:RO_0000057op some obo:TXPO_0001068c
obo:RO_0000057op some obo:TXPO_0001046c
obo:RO_0000057op some obo:TXPO_0001053c
obo:TXPO_0000069op some obo:TXPO_0000174c
obo:RO_0000057op some obo:TXPO_0001067c

PERK signaling to eIF2a [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002449
Super-classes obo:TXPO_0001717c
obo:TXPO_0000062c
Restrictions obo:BFO_0000051op some obo:TXPO_0000402c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002378c
Sub-classes obo:TXPO_0002849c
obo:TXPO_0002440c
obo:TXPO_0002412c
obo:TXPO_0003059c
obo:TXPO_0002991c
obo:TXPO_0000061c

decreased amountc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002450
Super-classes obo:PATO_0000070c

hyperfunction of peroxisomal fatty acid beta-oxidation (severe) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002451
Super-classes obo:TXPO_0000176c
obo:TXPO_0000177c
Restrictions obo:RO_0000057op some obo:TXPO_0001074c
obo:TXPO_0000069op some obo:TXPO_0002391c
obo:BFO_0000066op some obo:GO_0005777c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0000103c
obo:RO_0000057op some obo:TXPO_0001060c
obo:RO_0000057op some obo:TXPO_0003250c
obo:RO_0000057op some obo:TXPO_0001061c

bromobenzene [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002452
Super-classes obo:TXPO_0001921c
obo:CHEBI_3179c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

Gclc (mouse)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002453
Super-classes obo:TXPO_0002285c
obo:TXPO_1000163c
Restrictions obo:RO_0000087op some obo:TXPO_0002394c
obo:TXPO_0000756op some obo:TXPO_0000489c

signaling molecule activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002454
Super-classes obo:TXPO_0000023c
Restrictions obo:TXPO_0000069op some obo:GO_0023052c

excretion of glutathione conjugates from hepatocyte to bile tubec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002455
Super-classes obo:TXPO_0002551c

excretion of glutathione conjugates from hepatocyte to bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002456
Super-classes obo:TXPO_0002551c

glutathione export from hepatocyte to bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002457
Super-classes obo:TXPO_0002480c

refolding-unfolding imbalance [ER stress (mild) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002458
Super-classes obo:TXPO_0000147c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0001977c
obo:TXPO_0001733op some obo:TXPO_0000680c
obo:TXPO_0000774op only obo:TXPO_0002528c

refolding-unfolding imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002459
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0003533c
obo:TXPO_0000147c
obo:TXPO_0003532c

refolding-unfolding imbalance [ER stress (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002460
Super-classes obo:TXPO_0000147c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0002470c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001733op some obo:TXPO_0001781c

PERK-NRF2 signal integration systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002461
Super-classes obo:TXPO_0001529c
Restrictions obo:RO_0002351op some obo:TXPO_0002526c

flow rate attributec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002462
Super-classes obo:PATO_0001906c

signaling receptorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002463
Description

related molecular function GO:0004872
Super-classes obo:TXPO_0003728c
Sub-classes obo:TXPO_0003441c
obo:TXPO_0000057c
obo:TXPO_0003224c

stress sensor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002464
Super-classes obo:TXPO_0000023c

Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgic # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002465
Super-classes obo:TXPO_0000460c
Restrictions obo:RO_0002338op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0001904c
obo:RO_0002339op some obo:GO_0005794c
Sub-classes obo:TXPO_0002466c

Transport ATF-6 from the endoplasmic reticulum (ER) to the Golgi [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002466
Description

The association between ATF6-alpha and BiP causes ATF6-alpha to be retained in the endoplasmic reticulum (ER). Once dissociated from BiP, the 2 Golgi Localization Sequences on ATF6-alpha are exposed and ATF6-alpha transits from the ER to the Golgi Apparatus.
Super-classes obo:TXPO_0002465c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0000044c
obo:RO_0002233op some obo:TXPO_0002900c
obo:RO_0002339op some obo:GO_0005794c
obo:RO_0002338op some obo:GO_0005783c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002467c

ATF6 processing [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002467
Super-classes obo:TXPO_0003063c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000012op some obo:TXPO_0000049c
obo:RO_0002234op some obo:TXPO_0002901c
obo:TXPO_0000012op some obo:TXPO_0000349c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002233op some obo:TXPO_0002900c

ATF6F (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002468
Super-classes obo:TXPO_0000879c
Sub-classes obo:TXPO_0002899c
obo:TXPO_0002913c
obo:TXPO_0003046c

increasing demand for protein refolding [ER stress (sustained)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002469
Super-classes obo:TXPO_0002211c
obo:TXPO_0001717c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002460c

accumulation of abnormal proteins in ER [ER stress (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002470
Super-classes obo:TXPO_0000194c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0002479c

increasing demand for protein degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002471
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0002472c

increasing demand for abnormal protein degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002472
Super-classes obo:TXPO_0002471c
Sub-classes obo:TXPO_0002473c

increasing demand for abnormal protein degradation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002473
Super-classes obo:TXPO_0001717c
obo:TXPO_0002472c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002479c
obo:TXPO_0000774op only obo:TXPO_0002528c

protein refolding insufficiencyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002474
Super-classes obo:TXPO_0000482c
Sub-classes obo:TXPO_0002177c

protein refolding insufficiency (sustained) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002475
Super-classes obo:TXPO_0001717c
obo:TXPO_0002177c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002460c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:GO_0005783c

protein degradation insufficiencyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002476
Super-classes obo:TXPO_0000482c
Sub-classes obo:TXPO_0002477c

protein degradation insufficiency [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002477
Super-classes obo:TXPO_0001717c
obo:TXPO_0002476c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002479c
obo:BFO_0000066op some obo:GO_0005737c

abnormal protein production- degradation imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002478
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0002479c

abnormal protein production- degradation imbalance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002479
Super-classes obo:TXPO_0001717c
obo:TXPO_0002478c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000250c

glutathione export from hepatocyte to bile tubec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002480
Super-classes obo:TXPO_0002488c
Sub-classes obo:TXPO_0002457c

phosphatidylinositol 3-kinase signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002481
Super-classes obo:TXPO_0000609c

caspase pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002482
Super-classes obo:TXPO_0000609c
Restrictions obo:BFO_0000051op some obo:TXPO_0000444c
Sub-classes obo:TXPO_0003102c

ATF4 gene regulation pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002483
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0002964c
Sub-classes obo:TXPO_0002484c
obo:TXPO_0002963c

ATF4 gene regulation pathway [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002484
Super-classes obo:TXPO_0002483c

CHOP gene regulation pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002485
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0001874c
Sub-classes obo:TXPO_0002961c

XBP1s gene regulation pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002486
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0002606c
Sub-classes obo:TXPO_0002959c
obo:TXPO_0002984c
obo:TXPO_0002960c

IRE1-mediated unfolded protein response [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002487
Super-classes obo:GO_0036498c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002956c
obo:TXPO_0002877c
obo:TXPO_0002875c
obo:TXPO_0002878c
obo:TXPO_0002876c
obo:TXPO_0002879c

glutathione export from hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002488
Super-classes obo:GO_0034635c
Restrictions obo:RO_0002338op some obo:CL_0000182c
Sub-classes obo:TXPO_0002480c
obo:TXPO_0002491c

PI3K-AKT signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002489
Super-classes obo:TXPO_0000027c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002481c
obo:TXPO_0002524op some obo:GO_0043491c

NRF2 signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002490
Super-classes obo:TXPO_0000027c
Restrictions obo:BFO_0000051op some obo:TXPO_0002763c
Sub-classes obo:TXPO_0002962c

glutathione export from hepatocyte [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002491
Super-classes obo:TXPO_0000889c
obo:TXPO_0002488c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002787c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0001868op some obo:TXPO_0002493c
obo:TXPO_0001868op some obo:TXPO_0002512c

dissociation of NF-kappaB-I-kappaBc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002492
Super-classes obo:TXPO_0000462c
Sub-classes obo:TXPO_0002791c

MRP2 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002493
Super-classes obo:TXPO_0002045c
obo:TXPO_0002496c

NF-kappaB transport into nucleusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002494
Super-classes obo:GO_0051169c
Restrictions obo:RO_0002339op some obo:GO_0005634c
Sub-classes obo:HINO_0017769c

I-kappaB phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002495
Super-classes obo:GO_0016310c
Sub-classes obo:TXPO_0002772c
obo:TXPO_0002808c

ABCC2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002496
Super-classes obo:TXPO_0002694c
Sub-classes obo:TXPO_0001032c
obo:TXPO_0003263c
obo:TXPO_0002493c

ERO1 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002497
Super-classes obo:TXPO_0000871c
obo:TXPO_1000135c

IGFBP1 gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002498
Super-classes obo:TXPO_0002967c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002547c
obo:TXPO_0001868op some obo:TXPO_0002560c
obo:TXPO_0000774op only obo:TXPO_0002528c

abnormal protein production [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002499
Super-classes obo:TXPO_0001717c
obo:TXPO_0002183c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

ABCC1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002500
Super-classes obo:TXPO_0002694c
Sub-classes obo:TXPO_0002512c

Peroxisome Proliferator-Activated Receptor Alpha [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002501
Super-classes obo:TXPO_0003516c
obo:TXPO_0000159c

hyperfunction of protein unfolding (sustained) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002502
Super-classes obo:TXPO_0002718c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000012op some obo:TXPO_0000037c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000012op some obo:TXPO_0001965c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002460c

accumulation of compound in ER [ER stress (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002503
Super-classes obo:TXPO_0001717c
obo:TXPO_0002212c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:RO_0000057op some obo:TXPO_0001962c
obo:RO_0000057op some obo:TXPO_0001980c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002502c

hyperfunction of repeated protein unfolding [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002504
Super-classes obo:TXPO_0002718c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000012op some obo:TXPO_0001965c
obo:TXPO_0000069op some obo:TXPO_0002469c
obo:TXPO_0000012op some obo:TXPO_0000037c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:GO_0005783c

protein aggregation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002505
Description

Protein aggretates are often insoluble and tend to sequester Fe 2+ ions. Fe 2+ helps to produce ROS.
Super-classes obo:TXPO_0002661c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000204c
obo:TXPO_0000774op only obo:TXPO_0002528c

changing activity of eIF2a by PERK [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002506
Super-classes obo:TXPO_0002378c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002507c
obo:TXPO_0000069op some obo:TXPO_0002762c
obo:TXPO_0000774op only obo:TXPO_0002528c

Phosphorylation of eIF2-alpha by PERK [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002507
Description

The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1.
Super-classes obo:TXPO_0000700c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002988c

Phosphorylation of eIF2-alpha by PERK [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002508
Description

The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1.
Super-classes obo:TXPO_0000700c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000707c
obo:TXPO_0000774op only obo:TXPO_0002528c

Phosphorylation of eIF2-alpha by PERK [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002509
Description

The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1.
Super-classes obo:TXPO_0000700c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002721c
obo:TXPO_0000774op only obo:TXPO_0002528c

Phosphorylation of eIF2-alpha by PERK [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002510
Description

The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1.
Super-classes obo:TXPO_0000700c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003035c
obo:TXPO_0000774op only obo:TXPO_0002528c

chaperone gene regulation pathway by ATF6 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002511
Super-classes obo:TXPO_0002520c
Restrictions obo:BFO_0000051op some obo:TXPO_0002393c

ABCC1(canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002512
Super-classes obo:TXPO_0002045c
obo:TXPO_0002500c

PERK-eIF2a-ATF4 mediated pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002513
Super-classes obo:TXPO_0000701c
Restrictions obo:BFO_0000051op some obo:TXPO_0000706c
obo:BFO_0000051op some obo:TXPO_0002433c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0002483c
Sub-classes obo:TXPO_0002561c
obo:TXPO_0003058c
obo:TXPO_0002519c
obo:TXPO_0002624c

PERK activation [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002514
Super-classes obo:TXPO_0000402c
Restrictions obo:TXPO_0000012op some obo:TXPO_0000063c
obo:TXPO_0000012op some obo:TXPO_0000388c
obo:TXPO_0000069op some obo:TXPO_0002506c
obo:TXPO_0000774op only obo:TXPO_0002528c

PERK activation [ER stress - apoptosis (sutained ) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002515
Super-classes obo:TXPO_0000402c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002517c
obo:RO_0000086op some obo:PATO_0000498c
obo:TXPO_0000774op only obo:TXPO_0002528c

PERK activation [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002516
Super-classes obo:TXPO_0000402c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002518c
obo:TXPO_0000774op only obo:TXPO_0002528c

changing activity of eIF2a by PERK [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002517
Super-classes obo:TXPO_0002378c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002509c
obo:TXPO_0000774op only obo:TXPO_0002528c

changing activity of eIF2a by PERK [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002518
Super-classes obo:TXPO_0002378c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000707c
obo:BFO_0000051op some obo:TXPO_0000700c

PERK-ATF4-CHOP signaling [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002519
Super-classes obo:TXPO_0002513c
Restrictions obo:BFO_0000051op some obo:TXPO_0002440c
obo:TXPO_0002524op some obo:TXPO_0002483c
obo:TXPO_0002524op some obo:TXPO_0002485c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:BFO_0000051op some obo:TXPO_0002721c
obo:BFO_0000051op some obo:TXPO_0002767c
obo:BFO_0000051op some obo:TXPO_0002722c
obo:TXPO_0000774op only obo:TXPO_0002528c

ATF6 gene regulation pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002520
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0002521c
Sub-classes obo:TXPO_0002511c
obo:TXPO_0003033c
obo:TXPO_0003084c

The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA) by ATF6.c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002521
Super-classes obo:TXPO_0000375c
Sub-classes obo:TXPO_0003045c
obo:TXPO_0002393c
obo:TXPO_0002912c

CAD accumulation in lysosome [Phospholipidosis (latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002522
Super-classes obo:TXPO_0003367c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001964c
obo:TXPO_0000069op some obo:TXPO_0001908c

NRf2 gene expression regulation systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002526
Super-classes obo:TXPO_0000887c

NRF2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002527
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004780c
obo:RO_0000087op some obo:TXPO_0003645c
Sub-classes obo:TXPO_0000047c
obo:TXPO_0002392c
obo:TXPO_0005120c
obo:TXPO_0003477c

endoplasmic reticulum stress [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002528
Description

The ER stress is a cellular response that occurs after sustained pertubation of ER protein synthesis, folding, and export machinery. Tis is likely to be induced by oxidative or covalent modification of ER proteins, which leads to misfolding of proteins.
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0002116c
obo:BFO_0000051op some obo:TXPO_0000831c
obo:BFO_0000051op some obo:TXPO_0003490c
obo:BFO_0000051op some obo:TXPO_0003276c
obo:BFO_0000051op some obo:TXPO_0001977c
obo:BFO_0000051op some obo:TXPO_0000760c
obo:BFO_0000051op some obo:TXPO_0001810c
obo:BFO_0000051op some obo:TXPO_0000722c
obo:BFO_0000051op some obo:TXPO_0002199c
obo:BFO_0000051op some obo:TXPO_0000170c
obo:BFO_0000051op some obo:TXPO_0002175c
obo:BFO_0000051op some obo:TXPO_0002194c
obo:BFO_0000051op some obo:TXPO_0002200c
obo:BFO_0000051op some obo:TXPO_0000206c
obo:BFO_0000051op some obo:TXPO_0003008c
obo:BFO_0000051op some obo:TXPO_0002197c
obo:BFO_0000051op some obo:TXPO_0000758c
obo:BFO_0000051op some obo:TXPO_0002161c
obo:BFO_0000051op some obo:TXPO_0002114c
obo:BFO_0000051op some obo:TXPO_0000569c
obo:BFO_0000051op some obo:TXPO_0002188c
obo:BFO_0000051op some obo:TXPO_0000817c
obo:BFO_0000051op some obo:TXPO_0000250c
obo:BFO_0000051op some obo:TXPO_0002532c
obo:BFO_0000051op some obo:TXPO_0000413c
obo:BFO_0000051op some obo:TXPO_0002751c
obo:BFO_0000051op some obo:TXPO_0000204c
obo:BFO_0000051op some obo:TXPO_0002544c
obo:BFO_0000051op some obo:TXPO_0000386c
obo:BFO_0000051op some obo:TXPO_0002503c
obo:BFO_0000051op some obo:TXPO_0002470c
obo:BFO_0000051op some obo:TXPO_0000342c
obo:BFO_0000051op some obo:TXPO_0000214c
obo:BFO_0000051op some obo:TXPO_0002535c
obo:BFO_0000051op some obo:TXPO_0002204c
obo:BFO_0000051op some obo:TXPO_0002505c
obo:BFO_0000051op some obo:TXPO_0002746c
obo:BFO_0000051op some obo:TXPO_0000513c
obo:BFO_0000051op some obo:TXPO_0002171c
obo:BFO_0000051op some obo:TXPO_0003270c
obo:BFO_0000051op some obo:TXPO_0002172c
obo:BFO_0000051op some obo:TXPO_0002534c
obo:BFO_0000051op some obo:TXPO_0002533c
obo:BFO_0000051op some obo:TXPO_0000767c
obo:BFO_0000051op some obo:TXPO_0002502c
obo:BFO_0000051op some obo:TXPO_0001455c
obo:BFO_0000051op some obo:TXPO_0002479c
obo:BFO_0000051op some obo:TXPO_0002207c
obo:BFO_0000051op some obo:TXPO_0002539c
obo:BFO_0000051op some obo:TXPO_0002201c
obo:BFO_0000051op some obo:TXPO_0002209c
obo:BFO_0000051op some obo:TXPO_0002458c
obo:BFO_0000051op some obo:TXPO_0000752c
obo:BFO_0000051op some obo:TXPO_0003598c
obo:TXPO_0000004op some obo:TXPO_0002175c
obo:BFO_0000051op some obo:TXPO_0001965c
obo:BFO_0000051op some obo:TXPO_0002191c
obo:BFO_0000051op some obo:TXPO_0002529c
obo:BFO_0000051op some obo:TXPO_0002460c

aggregated protein production- degradation imbalance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002529
Super-classes obo:TXPO_0002530c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002532c
obo:TXPO_0000774op only obo:TXPO_0002528c

aggregated protein production- degradation imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002530
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0002529c

increasing number of abnormal cells in liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002531
Super-classes obo:TXPO_0000093c
Restrictions obo:RO_0002234op some (obo:TXPO_0004047c and ub744bL76620C17c)
obo:BFO_0000066op some obo:UBERON_0002107c
Sub-classes obo:TXPO_0002532c

increasing number of abnormal cells in liver [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002532
Super-classes obo:TXPO_0001717c
obo:TXPO_0002531c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002114c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0002528c

hyperfunction of cell survival[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002533
Super-classes obo:TXPO_0002275c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000831c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0003598c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000758c

carcinogenesis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002534
Super-classes obo:NCIT_C18078c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000758c
obo:TXPO_0000069op some obo:TXPO_0000767c
obo:TXPO_0000069op some obo:TXPO_0002535c

tumor cell proliferation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002535
Super-classes obo:TXPO_0000339c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

increasing hepatocellular volume [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002536
Super-classes obo:TXPO_0001717c
obo:TXPO_0000164c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

negative regulation of increasing insulin resistancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002537
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0002189c
Sub-classes obo:TXPO_0002547c
obo:TXPO_0003352c

increasing volume of liver [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002538
Super-classes obo:TXPO_0000616c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

protein quality control for unfolded proteins [ER stress (early stage)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002539
Super-classes obo:TXPO_0001717c
obo:TXPO_0000213c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002544c
obo:BFO_0000051op some obo:TXPO_0002207c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:CL_0000000c
obo:BFO_0000051op some obo:TXPO_0000722c

GRP78 - chaperone (canonical)[ER stress - refolding [early stage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002540
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
obo:RO_0000056op some obo:TXPO_0002207c

optional contribution processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002541
Super-classes obo:TXPO_0000600c
Sub-classes obo:TXPO_0002542c
obo:TXPO_0000113c
obo:TXPO_0003311c

enhancingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002542
Super-classes obo:TXPO_0002541c

nuclear chromosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002543
Super-classes obo:GO_0005694c
Restrictions obo:BFO_0000050op some obo:GO_0005634c

protein quality control for unfolded proteins [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002544
Super-classes obo:TXPO_0001717c
obo:TXPO_0000213c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000569c
obo:BFO_0000051op some obo:TXPO_0000214c
obo:BFO_0000066op some obo:CL_0000000c
obo:BFO_0000051op some obo:TXPO_0002539c
obo:TXPO_0000774op only obo:TXPO_0002528c

regulation of lipolytic gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002545
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0002047c

refolding promoting gene expression by ATF6 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002546
Super-classes obo:TXPO_0002716c
obo:TXPO_0003736c
Restrictions obo:BFO_0000051op some obo:TXPO_0002393c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002550c
obo:BFO_0000051op some obo:TXPO_0002447c
obo:TXPO_0002524op some obo:TXPO_0002549c

negative regulation of increasing insulin resistance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002547
Super-classes obo:TXPO_0002537c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

ATF6 signaling (integrated pathway)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002548
Super-classes obo:TXPO_0000027c
Restrictions obo:BFO_0000051op some obo:TXPO_0002554c
obo:BFO_0000051op some obo:TXPO_0000718c
obo:TXPO_0002524op some obo:TXPO_0002126c
obo:TXPO_0002524op some obo:TXPO_0002520c
obo:BFO_0000051op some obo:TXPO_0002521c
Sub-classes obo:TXPO_0002549c
obo:TXPO_0002796c
obo:TXPO_0003044c
obo:TXPO_0002908c

ATF6 mediated chaperon gene producion pathway [ER stress -refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002549
Super-classes obo:TXPO_0002548c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002511c
obo:TXPO_0000774op only obo:TXPO_0000413c
obo:BFO_0000051op some obo:TXPO_0002393c
obo:BFO_0000051op some obo:TXPO_0002447c
obo:BFO_0000051op some obo:TXPO_0002550c

ATF6 signaling (primitive) [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002550
Super-classes obo:TXPO_0000719c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002175c
obo:TXPO_0000069op some obo:TXPO_0002393c
obo:BFO_0000051op some obo:TXPO_0001905c
obo:TXPO_0001868op some obo:TXPO_0002901c

excretion of glutathione conjugates from hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002551
Super-classes obo:TXPO_0002077c
Sub-classes obo:TXPO_0002456c
obo:TXPO_0002564c
obo:TXPO_0002455c

blood coagulation factor synthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002552
Super-classes obo:GO_0009058c

CYP4A11 - tumor progression marker (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002553
Super-classes obo:TXPO_0001859c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001579c
obo:RO_0000087op some obo:TXPO_0000080c

receiving signal by ATF6 [ATF6 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002554
Super-classes obo:TXPO_0002174c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000879c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0000718c
Sub-classes obo:TXPO_0003030c
obo:TXPO_0002447c

P-EIF2A - translation initiation inhibitor (canonical)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002555
Super-classes obo:TXPO_0000829c
Restrictions obo:RO_0000087op some obo:TXPO_0001909c

P-EIF2A -ATF4 promoting factor (canonical)[ER stress - proteinrefolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002556
Super-classes obo:TXPO_0000829c
Restrictions obo:RO_0000087op some obo:TXPO_0002557c

translation regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002557
Super-classes obo:TXPO_0003230c
Sub-classes obo:TXPO_0001909c
obo:TXPO_0002933c

ATF4 - transcriptional regulator (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002558
Super-classes obo:TXPO_0001907c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

ATF4 - transcriptional regulator (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002559
Super-classes obo:TXPO_0001907c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0000774op only obo:TXPO_0000760c

ATF4 - transcriptional regulator (canonical)[ER stress - insulin resistance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002560
Super-classes obo:TXPO_0001907c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

PERK-ATF4-TRIB3 signaling [ER stress - insulin resistance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002561
Super-classes obo:TXPO_0002513c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:BFO_0000051op some obo:TXPO_0002562c
obo:TXPO_0002524op some obo:TXPO_0002483c

Trib3 gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002562
Super-classes obo:TXPO_0000698c
Restrictions obo:RO_0002234op some obo:TXPO_0002168c
obo:TXPO_0000069op some obo:TXPO_0002201c
obo:TXPO_0001868op some obo:TXPO_0001907c

IRE1 signaling (integrated pathway)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002563
Super-classes obo:TXPO_0000027c
Restrictions obo:BFO_0000051op some obo:GO_0010468c
obo:BFO_0000051op some obo:TXPO_0002604c
obo:TXPO_0002524op some obo:TXPO_0002155c
obo:BFO_0000051op some obo:TXPO_0002593c
Sub-classes obo:TXPO_0002599c
obo:TXPO_0002609c
obo:TXPO_0002795c
obo:TXPO_0002610c
obo:TXPO_0002936c
obo:TXPO_0002836c

excretion of glutathione conjugates from hepatocyte [Glutathione depletion.]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002564
Super-classes obo:TXPO_0000889c
obo:TXPO_0002551c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0002493c

changing protein foldc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002565
Super-classes obo:TXPO_0000660c
Sub-classes obo:GO_0043335c
obo:GO_0006457c

changing structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002566
Super-classes obo:TXPO_0000392c
Sub-classes obo:TXPO_0000660c
obo:TXPO_0000168c
obo:TXPO_0000410c
obo:TXPO_0001770c
obo:TXPO_0002656c
obo:TXPO_0000238c
obo:GO_0006338c
obo:TXPO_0003733c
obo:GO_0051276c
obo:TXPO_0000222c
obo:TXPO_0001440c

converting to informationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002567
Super-classes obo:TXPO_0002282c
Sub-classes obo:TXPO_0000389c

changing compositionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002568
Super-classes obo:TXPO_0000261c
Sub-classes obo:TXPO_0000468c

combiningc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002569
Super-classes obo:TXPO_0000468c
Sub-classes obo:TXPO_0000469c

dissolvingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002570
Super-classes obo:TXPO_0000468c
Sub-classes obo:TXPO_0002235c

IRE1 signaling (primitive) [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002571
Super-classes obo:TXPO_0003736c
obo:TXPO_0000720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002591c
Sub-classes obo:TXPO_0002684c
obo:TXPO_0002761c
obo:TXPO_0002594c
obo:TXPO_0002831c
obo:TXPO_0002953c
obo:TXPO_0000721c
obo:TXPO_0002709c

CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002572
Super-classes obo:TXPO_0001399c
Restrictions obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000069op some obo:TXPO_0003578c
obo:TXPO_0000774op only obo:TXPO_0001964c
obo:RO_0002212op some obo:TXPO_0003404c

mixingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002573
Super-classes obo:TXPO_0000468c

composingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002574
Super-classes obo:TXPO_0000468c

gatheringc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002575
Super-classes obo:TXPO_0000468c

splittingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002576
Super-classes obo:TXPO_0000333c
Sub-classes obo:GO_0051301c
obo:GO_0000266c

takingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002577
Super-classes obo:TXPO_0000333c
Sub-classes obo:TXPO_0002578c
obo:TXPO_0000458c

extractingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002578
Super-classes obo:TXPO_0002577c
Sub-classes obo:TXPO_0001534c

FNIP2 (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002579
Super-classes obo:TXPO_0001135c
obo:TXPO_0003837c
Restrictions obo:TXPO_0000819op some obo:OGG_3000057600c
obo:RO_0000086op some obo:TXPO_0000657c

decreasing distancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002580
Super-classes obo:TXPO_0000465c
Sub-classes obo:TXPO_0002581c

making contact between A and Bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002581
Super-classes obo:TXPO_0002580c
Sub-classes obo:GO_0007155c

Glutathione conjugation (supply) - function demand imbalance (severe) [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002582
Super-classes obo:TXPO_0002302c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

keeping distancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002583
Super-classes obo:TXPO_0000465c
Sub-classes obo:TXPO_0002584c
obo:TXPO_0002585c

keeping adhesivityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002584
Super-classes obo:TXPO_0002583c

keeping distance (>0)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002585
Super-classes obo:TXPO_0002583c

changing the relationship between inside and outsidec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002586
Super-classes obo:TXPO_0000464c
Sub-classes obo:TXPO_0002587c
obo:TXPO_0002588c

moving A to the inside of Bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002587
Super-classes obo:TXPO_0002586c
Restrictions obo:RO_0002233op some obo:BFO_0000002c
Sub-classes obo:TXPO_0001270c
obo:GO_0010324c
obo:TXPO_0001231c
obo:TXPO_0001224c
obo:TXPO_0002123c
obo:GO_0007631c
obo:TXPO_0000540c
obo:GO_0006909c
obo:TXPO_0000312c
obo:TXPO_0001684c
obo:TXPO_0003318c
obo:GO_0006897c
obo:TXPO_0003402c

moving A to the outside of Bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002588
Super-classes obo:TXPO_0002586c
Restrictions obo:RO_0002234op some obo:BFO_0000002c
Sub-classes obo:TXPO_0001356c
obo:GO_0030073c
obo:GO_0001836c
obo:TXPO_0000163c
obo:GO_0033700c
obo:TXPO_0002683c
obo:TXPO_0001353c
obo:TXPO_0003539c
obo:TXPO_0003609c
obo:TXPO_0000457c
obo:TXPO_0004035c
obo:GO_0050663c
obo:GO_0033344c
obo:TXPO_0001863c
obo:GO_0046618c
obo:TXPO_0005139c
obo:GO_0032782c
obo:TXPO_0001699c
obo:TXPO_0002231c
obo:TXPO_0001271c

discharging unnecessary objectc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002589
Super-classes obo:TXPO_0000459c

changing materialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002590
Super-classes obo:TXPO_0000261c
Sub-classes obo:GO_0042246c
obo:TXPO_0000219c
obo:TXPO_0001470c
obo:TXPO_0000192c

IRE1 activation [IRE1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002591
Super-classes obo:TXPO_0000729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002592c
obo:TXPO_0000012op some obo:TXPO_0002595c
obo:TXPO_0000012op some obo:TXPO_0002597c
Sub-classes obo:TXPO_0000730c

XBP1 activation by IRE1 [IRE1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002592
Description

The XBP1 gene is transcribed to yield mRNA, which is spliced and translated to transcription factor Xbp(s).
Super-classes obo:TXPO_0000723c
Restrictions obo:TXPO_0000012op some obo:TXPO_0000725c
Sub-classes obo:TXPO_0002690c

IRE1 signaling (primitive) [IRE1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002593
Super-classes obo:TXPO_0000720c
Restrictions obo:BFO_0000051op some obo:TXPO_0002591c

IRE1 signaling to TRAF2 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002594
Super-classes obo:TXPO_0002571c
Restrictions obo:BFO_0000051op some obo:TXPO_0002816c
Sub-classes obo:TXPO_0002835c
obo:TXPO_0002834c

IRE1 dimerizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002595
Super-classes obo:TXPO_0003641c
Restrictions obo:RO_0000057op some obo:TXPO_0002883c
Sub-classes obo:TXPO_0002596c

IRE1 dimerization [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002596
Super-classes obo:TXPO_0003736c
obo:TXPO_0002595c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002598c
obo:RO_0000057op some obo:TXPO_0002972c
Sub-classes obo:TXPO_0002975c
obo:TXPO_0003089c
obo:TXPO_0002971c

IRE1 autophosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002597
Super-classes obo:GO_0046777c
Sub-classes obo:TXPO_0002598c

IRE1 autophosphorylation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002598
Super-classes obo:TXPO_0003736c
obo:TXPO_0002597c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0002601c
Sub-classes obo:TXPO_0002977c
obo:TXPO_0002976c
obo:TXPO_0003064c

IRE1-Traf2-ASK-JNK-AP1 pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002599
Super-classes obo:TXPO_0002563c
Restrictions obo:BFO_0000051op some obo:TXPO_0002821c
obo:BFO_0000051op some obo:TXPO_0002833c
obo:BFO_0000051op some obo:TXPO_0002827c
obo:TXPO_0002524op some obo:TXPO_0002878c
obo:BFO_0000051op some obo:TXPO_0002823c

hyperfunction of moving drug to the inside of liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002600
Super-classes obo:TXPO_0002359c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001827c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000716op some obo:TXPO_0001714c
Sub-classes obo:TXPO_0002719c

IRE1 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002601
Super-classes obo:TXPO_0001528c
obo:TXPO_0000871c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002595c
obo:TXPO_0001896op some obo:TXPO_0002597c
Sub-classes obo:TXPO_0002978c
obo:TXPO_0002602c
obo:TXPO_0003088c
obo:TXPO_0002979c
obo:TXPO_0002603c

IRE1 - signal sensor (canonical)[IRE1 signalling system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002602
Super-classes obo:TXPO_0002601c
Restrictions obo:RO_0000087op some obo:TXPO_0000882c
obo:RO_0000056op some obo:TXPO_0002604c
Sub-classes obo:TXPO_0000875c
obo:TXPO_0002886c
obo:TXPO_0000824c
obo:TXPO_0002890c
obo:TXPO_0000906c

IRE1 - signaling factor (canonical)[IRE1 signalling system]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002603
Super-classes obo:TXPO_0002601c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0001896op some obo:TXPO_0002593c
Sub-classes obo:TXPO_0002941c
obo:TXPO_0002891c
obo:TXPO_0002892c

receiving signal in IRE1 signal transduction pathway [ILE1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002604
Super-classes obo:TXPO_0002174c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002593c
Sub-classes obo:TXPO_0002957c
obo:TXPO_0002926c
obo:TXPO_0002710c
obo:TXPO_0002887c

XBP1 - transcriptional regulator (canonical)[ER stress -ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002605
Super-classes obo:TXPO_0001968c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002608c

gene expression by XBP1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002606
Super-classes obo:TXPO_0000375c
Sub-classes obo:TXPO_0002607c

gene expression by XBP1 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002607
Super-classes obo:TXPO_0002606c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0003065c
obo:TXPO_0002608c
obo:TXPO_0002919c

ERAD gene expression by XBP1 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002608
Super-classes obo:TXPO_0002607c

IRE1-XBP1 mediated pathway [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002609
Super-classes obo:TXPO_0002563c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002956c
obo:TXPO_0000774op only obo:TXPO_0000413c
obo:BFO_0000051op some obo:TXPO_0002761c
obo:BFO_0000051op some obo:TXPO_0002957c
obo:BFO_0000051op some obo:TXPO_0002919c
obo:TXPO_0002524op some obo:TXPO_0002959c

IRE1-XBP1 mediated pathway [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002610
Super-classes obo:TXPO_0002563c
Restrictions obo:BFO_0000051op some obo:TXPO_0002710c
obo:BFO_0000051op some obo:TXPO_0002608c
obo:TXPO_0002524op some obo:TXPO_0002877c
obo:BFO_0000051op some obo:TXPO_0002709c
obo:TXPO_0002524op some obo:TXPO_0002960c

Hyou gene expression by XBP1 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002611
Super-classes obo:TXPO_0002919c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c

DNAJB9 gene expression by XBP1 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002612
Super-classes obo:TXPO_0002919c
Restrictions obo:RO_0000057op some obo:TXPO_0002165c
obo:TXPO_0000774op only obo:TXPO_0000413c

hyperfunction of glutathione conjugates excretion from hepatocyte [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002613
Super-classes obo:TXPO_0000889c
obo:TXPO_0002701c
Restrictions obo:TXPO_0001502op some obo:TXPO_0002551c
obo:RO_0000057op some obo:TXPO_0002493c
obo:TXPO_0000069op some obo:TXPO_0002733c
obo:TXPO_0000774op only obo:TXPO_0000501c

cholesterol efflux (from heptocyte menbrane to canaliculus) [cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002614
Super-classes obo:GO_0033344c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0001868op some obo:TXPO_0002615c

ABCG5 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002615
Super-classes obo:TXPO_0001506c

ABCG8 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002616
Super-classes obo:TXPO_1000000c
obo:TXPO_0001506c

enabling translationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002617
Super-classes obo:TXPO_0001757c
Sub-classes obo:TXPO_0002751c

antioxidant gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002618
Super-classes obo:TXPO_0001717c
obo:TXPO_0002061c
Restrictions obo:BFO_0000051op some obo:TXPO_0000450c
obo:BFO_0000051op some obo:TXPO_0002744c
obo:TXPO_0002524op some obo:TXPO_0002740c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002739c
Sub-classes obo:TXPO_0002744c

GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [short-term]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002619
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000087op some obo:TXPO_0002620c
obo:RO_0000056op some obo:TXPO_0002207c

negative regulator role of stress sensorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002620
Super-classes obo:TXPO_0003711c

GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [persist] -IRE1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002621
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000087op some obo:TXPO_0002620c
obo:RO_0000056op some obo:TXPO_0002207c

GRP78 - stress sensor inhibitor (canonical)[ER stress - proteinrefolding [persist] -ATF6 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002622
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000056op some obo:TXPO_0002207c
obo:RO_0000087op some obo:TXPO_0002620c

nucleoside phosphatec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002623
Super-classes obo:CHEBI_37734c
Sub-classes obo:CHEBI_17677c
obo:CHEBI_17361c

PERK-eIF2a-ATF4 pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002624
Super-classes obo:TXPO_0002513c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0003035c
obo:TXPO_0002524op some obo:TXPO_0002483c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:BFO_0000051op some obo:TXPO_0003036c

PERK - signal sensor (canonical)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002625
Super-classes obo:TXPO_0001841c
Restrictions obo:RO_0000087op some obo:TXPO_0000882c
obo:TXPO_0001896op some obo:TXPO_0000123c

phosphatidylcholine efflux (from heptocyte menbrane to canaliculus) [cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002626
Description

Bile salts, by acting as detergents, release phosphatidylcholine from the outer can canalicular leaflet into the canaliculus
Super-classes obo:TXPO_0000034c
obo:TXPO_0003539c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002615c
obo:TXPO_0000774op only obo:TXPO_0001277c

phospholipid efflux (from heptocyte menbrane to canaliculus) [cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002627
Description

Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids.
Super-classes obo:TXPO_0000034c
obo:GO_0033700c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0001868op some obo:TXPO_0002631c

intracellular ligand-gated ion channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002628
Super-classes obo:TXPO_0003680c

autophagy regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002629
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0006914c
Sub-classes obo:TXPO_0000487c
obo:CHEBI_88230c

bile secretion (from heptocyte menbrane to canaliculus) [cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002630
Description

Bile circulation (whole body): From the blood vessel side (sinusoidal side) -> hepatocyte ttransport -> bile secretion/excretion from the bile duct side membrane to the capillary bile duct, then to the bile duct, duodenum, intestinal hepatic circulation.

Hepatocytes have polarity and have transporters in the membranes on the side of the sinusoidal side and the bile duct. Sinusoid side: OATP family (OATP 1 B 1, OATP 1 B 3): organic anion NTCP: Na dependent uptake MRP 3, 4: Excretion of organic anion from inside the liver into sinusoids

Bile duct membrane side: BSEP (ABCG 11): (amino acid conjugation) excretion of bile acid into the bile canaliculi MRP 2: Excretion of organic anions such as sulfate conjugated bile acid, glucuronic acid conjugated bile acid, conjugated bilirubin MDR1: cation excretion MDR 3: phospholipid excretion ABCG 5 / ABCG 8: cholesterol excretion
Super-classes obo:TXPO_0000034c
obo:TXPO_0002692c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

ABCB4 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002631
Super-classes obo:TXPO_0001506c

oranic anion export (from heptocyte menbrane to canaliculus) [cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002632
Description

Biliary organic anions other than bile salts are mainly conjugates of bilirubin and GSH.

Drug metabolites excreted into bile are also organic anions, which are transported by the two ABC transporters, MRP2 (canalicular multi specific organic anion transport 1/multi drug resistance-associated protein 2, ABCC2) and ABCG2 (ABCG2).
Super-classes obo:TXPO_0003609c
obo:TXPO_0000034c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002634c
obo:TXPO_0001868op some obo:TXPO_0002635c
obo:TXPO_0000774op only obo:TXPO_0001277c

Translocation of NF-kappaB [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002633
Super-classes obo:TXPO_0001717c
obo:TXPO_0002779c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0002768c
Sub-classes obo:TXPO_0002837c
obo:TXPO_0002804c
obo:TXPO_0002815c
obo:TXPO_0002814c

MRP2 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002634
Super-classes obo:TXPO_0001506c

ABCG2 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002635
Super-classes obo:TXPO_0001506c

MDR1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002636
Super-classes obo:TXPO_0001506c

drug export from the hepatocyte to to bile tube [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002637
Description

Export into the canaliculus is mediated by MDR1 . MDR1 is also expressed at many oegan boundaries.
Super-classes obo:TXPO_0003153c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0001868op some obo:TXPO_0002636c
obo:TXPO_0001868op some obo:TXPO_0002635c

expcretion of drug metabolite from hepatocyte to bile tube [cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002638
Description

Export into the canaliculus is mediated by MDR1 . MDR1 is also expressed at many organ boundaries.
Super-classes obo:TXPO_0000034c
obo:TXPO_0003152c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002634c
obo:TXPO_0000774op only obo:TXPO_0001277c

importing substance into hepatocyte vascular side (sinusoidal side) membrane [cholestasis] [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002639
Super-classes obo:TXPO_0001759c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002642c
obo:TXPO_0001868op some obo:TXPO_0002640c

MRP3 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002640
Super-classes obo:TXPO_0001506c

bile tube occlusion [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002641
Super-classes obo:TXPO_0000034c
obo:TXPO_0002713c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

MRP4 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002642
Super-classes obo:TXPO_0001506c
obo:TXPO_0003019c

FXR (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002643
Description

https://omim.org/entry/603826
Super-classes obo:TXPO_0000276c
obo:TXPO_0003119c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

farnesoid X receptor activation [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002644
Description

Bile salts activate a bile salt sensor, FXR (bile acid receptor; NR1H4) in hepatocytes.
Super-classes obo:TXPO_0000034c
obo:TXPO_0003143c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003147c
obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0001868op some obo:TXPO_0000509c
obo:RO_0002234op some obo:TXPO_0002643c

positive regulation of bile export [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002645
Description

FXR regulates of metabolic processes. Activation of FXR by increased bile salt concentrations in hepatocytes downregulates the uptake systems for bile salts and maintains or upregulates bill salt efflux systems
Super-classes obo:TXPO_0002732c
obo:TXPO_0000034c
Restrictions obo:RO_0002234op some obo:TXPO_0000509c
obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0001868op some obo:TXPO_0002643c

negative regularuion of bile acid and bile salt transport [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002646
Description

FXR regulates of metabolic processes. Activation of FXR by increased bile salt concentrations in hepatocytes downregulates the uptake systems for bile salts and maintains or upregulates bill salt efflux systems
Super-classes obo:TXPO_0000034c
obo:TXPO_0003126c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

OCT family (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002647
Super-classes obo:TXPO_1000271c
obo:TXPO_0000276c
Sub-classes obo:TXPO_0002386c

decreasing cross-sectional areac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002648
Super-classes obo:TXPO_0000242c
Restrictions obo:TXPO_0000531op some obo:TXPO_0003625c
Sub-classes obo:TXPO_0003293c
obo:TXPO_0002655c

bile acid secretion [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002649
Description

Bile contains bile acids, glutathione, phospholipids, cholesterol, bilirubin, and other organic anions, proteins, metals, ions, and xenobiotics.

Hepatocytes begins the formation of bile by transporting bile acids, glutathione, and other solutes including Xenobiotics and their metabolites into the canalicular lumen.

The major driving force of bile formation is the active transport of bile salts and other osmolytes into the canalicular lumen.

Most conjugated bile acids (taurine and glycine conjugates) and some unconjugated bile acids are transported into hepatocytes by sodium-dependent transporters.

Sodium-independent uptake of conjugated and unconjugated bile acids is performed by members of the organic anion-transporting polypeptides (OATPs). OATPs also transport numerous drugs and hepatotoxicants.

Lipophilic cationic drugs, estrogens, and lipids are exported by the canalicular multiple-drug resistance (MDR) P-glycoproteins, one of which is exclusive for phospholipids.

Conjugates of glutathione, glucuronide, and sulfate are exported by multidrug resistance-associated protein2 (MRP2).
Super-classes obo:GO_0032782c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

intrahepatic cholestasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002650
Description

under construction
Super-classes obo:TXPO_0001277c
Restrictions obo:BFO_0000051op some obo:TXPO_0002652c
obo:BFO_0000051op some obo:TXPO_0000086c
obo:BFO_0000051op some obo:TXPO_0002664c
obo:BFO_0000051op some obo:TXPO_0000066c
obo:BFO_0000051op some obo:TXPO_0002630c
obo:BFO_0000051op some obo:TXPO_0003147c
obo:BFO_0000051op some obo:TXPO_0000268c
obo:BFO_0000051op some obo:TXPO_0002678c
obo:BFO_0000051op some obo:TXPO_0001759c
obo:BFO_0000051op some obo:TXPO_0002654c
obo:BFO_0000051op some obo:TXPO_0003136c
obo:BFO_0000051op some obo:TXPO_0002679c
obo:BFO_0000051op some obo:TXPO_0000089c
obo:BFO_0000051op some obo:TXPO_0003135c
obo:BFO_0000051op some obo:TXPO_0002637c
obo:BFO_0000051op some obo:TXPO_0002658c
obo:BFO_0000051op some obo:TXPO_0002644c
obo:BFO_0000051op some obo:TXPO_0003154c
obo:BFO_0000051op some obo:TXPO_0002638c
obo:BFO_0000051op some obo:TXPO_0002675c
obo:BFO_0000051op some obo:TXPO_0000264c
obo:BFO_0000051op some obo:TXPO_0003137c
obo:BFO_0000051op some obo:TXPO_0000545c
obo:BFO_0000051op some obo:TXPO_0003134c
obo:BFO_0000051op some obo:TXPO_0002676c
obo:BFO_0000051op some obo:TXPO_0003133c
obo:BFO_0000051op some obo:TXPO_0002674c
obo:BFO_0000051op some obo:TXPO_0002670c
obo:BFO_0000051op some obo:TXPO_0000041c
obo:BFO_0000051op some obo:TXPO_0000265c
obo:BFO_0000051op some obo:TXPO_0002666c
obo:BFO_0000051op some obo:TXPO_0001994c
obo:BFO_0000051op some obo:TXPO_0002641c
obo:BFO_0000051op some obo:TXPO_0002669c
obo:BFO_0000051op some obo:TXPO_0002659c
obo:BFO_0000051op some obo:TXPO_0002663c
obo:BFO_0000051op some obo:TXPO_0002646c
obo:BFO_0000051op some obo:TXPO_0002645c
obo:BFO_0000051op some obo:TXPO_0000084c
obo:BFO_0000051op some obo:TXPO_0002681c
obo:BFO_0000051op some obo:TXPO_0002660c
obo:BFO_0000051op some obo:TXPO_0002657c
obo:BFO_0000051op some obo:TXPO_0002649c
obo:BFO_0000051op some obo:TXPO_0002662c
Sub-classes obo:TXPO_0001278c
obo:TXPO_0001279c

extrahepatic cholestasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002651
Description

under construction
Super-classes obo:TXPO_0001277c

binding to bile canaliculus membrane transporter by drug [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002652
Super-classes obo:TXPO_0000034c
obo:TXPO_0003117c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

bile transport (import-export) imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002653
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0002654c

bile transport (import-export) imbalance [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002654
Super-classes obo:TXPO_0002653c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001278c
obo:BFO_0000066op some obo:UBERON_0001283c

biliary tract stenosisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002655
Super-classes obo:TXPO_0002648c
Restrictions obo:RO_0002234op some (obo:UBERON_0002394c and ub744bL78441C17c)

changing topologyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002656
Super-classes obo:TXPO_0002566c
Sub-classes obo:NCIT_C50678c

decreasing bile flow in bile canaliculus [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002657
Super-classes obo:TXPO_0002348c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000069op some obo:TXPO_0000350c

decreasing bile acid production level [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002658
Super-classes obo:TXPO_0000034c
obo:TXPO_0003140c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

regulation of bile acid and bile salt transport [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002659
Super-classes obo:TXPO_0000034c
obo:TXPO_0003637c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

bile thrombus formation in bile canaliculus [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002660
Super-classes obo:TXPO_0000034c
obo:TXPO_0003142c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

protein aggregationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002661
Super-classes obo:TXPO_0003815c
Restrictions obo:RO_0002233op some obo:CHEBI_36080c
Sub-classes obo:TXPO_0002505c

increasing vomume of bile canaliculus [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002662
Super-classes obo:TXPO_0002717c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

increasing canalicular membrane permeability [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002663
Super-classes obo:TXPO_0002706c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000069op some obo:TXPO_0002664c

bile reflux [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002664
Super-classes obo:TXPO_0000034c
obo:TXPO_0000590c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

regulation of cell survivalc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002665
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:NCIT_C16407c

contraction of bile canaliculus [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002666
Super-classes obo:TXPO_0002695c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

negative regulation of contractile movement of bile canaliculus [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002667
Super-classes obo:TXPO_0003155c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

phospholipidosis dependent molecule (HepG2_24h_sawada)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002668
Super-classes obo:TXPO_0001135c
Sub-classes obo:TXPO_0003330c
obo:TXPO_0003327c
obo:TXPO_0003337c
obo:TXPO_0003323c
obo:TXPO_0003325c
obo:TXPO_0003320c
obo:TXPO_0003334c
obo:TXPO_0003333c
obo:TXPO_0003324c
obo:TXPO_0000529c
obo:TXPO_0003339c
obo:TXPO_0003322c
obo:TXPO_0003335c

necrosis [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002669
Super-classes obo:TXPO_0000034c
obo:GO_0070265c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000069op some obo:TXPO_0003739c
obo:TXPO_0000069op some obo:TXPO_0000545c

inflammatory response [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002670
Super-classes obo:TXPO_0000192c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003154c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000069op some obo:TXPO_0003211c
obo:BFO_0000051op some obo:TXPO_0000639c

type I diabetes coursec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002671
Super-classes obo:TXPO_0002033c
Restrictions obo:BFO_0000051op some obo:TXPO_0002435c
obo:BFO_0000051op some obo:TXPO_0002437c
obo:BFO_0000051op some obo:TXPO_0003577c

decreasing flowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002672
Description

Decreasing flow is a deacreasing process to decrease the magnitude of the flow.
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0000359c
obo:TXPO_0002673c

decreasing bile flowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002673
Super-classes obo:TXPO_0002672c
Sub-classes obo:TXPO_0002674c
obo:TXPO_0002348c

decreasing bile flow [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002674
Super-classes obo:TXPO_0000034c
obo:TXPO_0002673c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

enterohepatic circulation [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002675
Description

Bile salts (>90%) are absorbed along the small intestine and transported back by the portal blood to the liver. They are taken up into hepatocytes and re-secreted into the canaliculi. This round trip of bile salts between the intestine and the liver is termed enterohepatic circulation.
Super-classes obo:TXPO_0000034c
obo:TXPO_0001979c

increasing bile concentration in blood [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002676
Super-classes obo:TXPO_0000034c
obo:TXPO_0002715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

GRP78 - chaperone (canonical)[ER stress - proteinrefolding (sustained)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002677
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c

acumulation of bile pigment in bile canaliculus [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002678
Super-classes obo:TXPO_0001906c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

acumulation of bile pigment in hepatocyte [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002679
Super-classes obo:TXPO_0000034c
obo:TXPO_0003150c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

XBP1 activation by IRE1 [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002680
Description

The XBP1 gene is transcribed to yield mRNA, the mRNA is spliced to yield Xbp(s) mRNA, and the mRNA is translated to yield protein.
Super-classes obo:TXPO_0002690c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000728c
obo:TXPO_0000012op some obo:TXPO_0002871c

negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002681
Description

Export into the canaliculus is mediated by the BSEP (bile salt export pump, ABCB11) . Rifampicin, bosentan, and troglitazone directly inhibit bile salt export pump (BSEP).
Super-classes obo:TXPO_0001892c
obo:TXPO_0000034c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001885c
obo:RO_0002212op some obo:TXPO_0002630c
obo:TXPO_0001868op some obo:TXPO_0000032c
obo:TXPO_0000069op some obo:TXPO_0000264c
obo:TXPO_0001868op some obo:TXPO_0000931c
obo:TXPO_0000774op only obo:TXPO_0001277c

negative regulation of transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002682
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0000441c
Sub-classes obo:TXPO_0004944c
obo:TXPO_0003126c
obo:TXPO_0001892c
obo:TXPO_0001391c
obo:TXPO_0004435c

bile secretionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002683
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:UBERON_0001970c
Sub-classes obo:TXPO_0002692c

IRE1 signaling (primitive) [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002684
Super-classes obo:TXPO_0002571c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002685c

IRE1 activation [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002685
Super-classes obo:TXPO_0000730c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002598c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002596c

IRE1 activation [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002686
Super-classes obo:TXPO_0000730c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002596c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002598c

IRE1 activation [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002687
Super-classes obo:TXPO_0000730c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002596c
obo:TXPO_0000012op some obo:TXPO_0002598c

IRE1 activation [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002688
Super-classes obo:TXPO_0000730c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002598c
obo:TXPO_0000012op some obo:TXPO_0002596c

XBP1 activation by IRE1 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002689
Description

The XBP1 gene is transcribed to yield mRNA, the mRNA is spliced to yield Xbp(s) mRNA, and the mRNA is translated to yield protein.
Super-classes obo:TXPO_0002690c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002851c
obo:TXPO_0000069op some obo:TXPO_0002919c

XBP1 activation by IRE1 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002690
Description

The XBP1 gene is transcribed to yield mRNA, the mRNA is spliced to yield Xbp(s) mRNA, and the mRNA is translated to yield protein.
Super-classes obo:TXPO_0003736c
obo:TXPO_0002592c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0001968c
obo:TXPO_0000012op some obo:TXPO_0000726c
Sub-classes obo:TXPO_0002832c
obo:TXPO_0002689c
obo:TXPO_0002680c

ATF6 signaling (primitive) [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002691
Super-classes obo:TXPO_0000719c
Restrictions obo:BFO_0000051op some obo:TXPO_0002918c
obo:TXPO_0000774op only obo:TXPO_0002204c
obo:TXPO_0001868op some obo:TXPO_0002901c

bile secretion to bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002692
Super-classes obo:TXPO_0002683c
Sub-classes obo:TXPO_0002630c

bile acid and bile salt transport to hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002693
Super-classes obo:GO_0015721c
Restrictions obo:RO_0002339op some obo:CL_0000182c
Sub-classes obo:TXPO_0001994c

ABC transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002694
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003018c
obo:TXPO_0001506c
obo:TXPO_0003019c
obo:TXPO_1000000c
obo:TXPO_0002496c
obo:TXPO_0002500c

contraction of bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002695
Super-classes obo:TXPO_0003129c
Sub-classes obo:TXPO_0002666c

ERAD related gene expression byXBP1s [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002696
Super-classes obo:TXPO_0000727c
obo:TXPO_0001717c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002605c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0002610c
obo:RO_0002234op some obo:TXPO_0002700c

glibenclamide [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002697
Description

OATP transporters are a critical factor controlling the uptake of glibenclamide by the liver. GLB is a substrate for OATP2B1 and OATP1B1, which are expressed at the sinusoidal membrane of hepatocytes.
Super-classes obo:CHEBI_5441c
obo:TXPO_0000749c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

importing substance into hepatocyte vascular side (sinusoidal side) membrane by OATP [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002698
Super-classes obo:TXPO_0001759c
Restrictions obo:RO_0000057op some obo:TXPO_0002702c
obo:TXPO_0001868op some obo:TXPO_0000272c
obo:RO_0002233op some obo:TXPO_0002697c

EDEM (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002699
Super-classes obo:TXPO_0000871c
obo:TXPO_0000298c
Restrictions obo:RO_0000087op some obo:TXPO_0003663c
Sub-classes obo:TXPO_0002700c

EDEM -ERAD promoting factor (canonical)[ER stress -ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002700
Super-classes obo:TXPO_0002699c

hyperfunctioning of glutathione conjugates excretion from hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002701
Super-classes obo:TXPO_0002279c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0001502op some obo:TXPO_0002551c
Sub-classes obo:TXPO_0002613c

prostaglandin [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002702
Super-classes obo:IMR_0100019c
obo:TXPO_0000749c

converting cell typec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002703
Super-classes obo:TXPO_0002282c
Sub-classes obo:NCIT_C18078c
obo:GO_0045445c

changing permeabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002704
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000232c
obo:TXPO_0003439c
obo:TXPO_0000094c

changing sizec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002705
Super-classes obo:TXPO_0000415c
Sub-classes obo:TXPO_0000220c
obo:TXPO_0000138c

increasing canalicular membrane permeabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002706
Super-classes obo:TXPO_0000232c
Sub-classes obo:TXPO_0002663c

estrone [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002707
Super-classes obo:TXPO_0000749c
obo:CHEBI_17263c
Restrictions obo:RO_0000087op some obo:TXPO_0002712c

hyperfunction of glutathione export from hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002708
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:TXPO_0002488c
Sub-classes obo:TXPO_0002711c

IRE1 signaling to XBP1 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002709
Super-classes obo:TXPO_0002571c
Restrictions obo:BFO_0000051op some obo:TXPO_0002685c
obo:BFO_0000051op some obo:TXPO_0002680c

receiving abnormal protein signal by IRE1 [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002710
Super-classes obo:TXPO_0003736c
obo:TXPO_0002604c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000875c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002709c

hyperfunction of glutathione export from hepatocyte [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002711
Super-classes obo:TXPO_0002708c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002733c
obo:TXPO_0001868op some obo:TXPO_0002512c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0001868op some obo:TXPO_0002493c

regulator of OATP bile acid transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002712
Super-classes obo:TXPO_0000056c

bile tube occlusionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002713
Super-classes obo:NCIT_C50678c
Sub-classes obo:TXPO_0002641c

increasing bile levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002714
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003136c

increasing bile concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002715
Super-classes obo:TXPO_0000352c
Sub-classes obo:TXPO_0002676c

refolding promoting gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002716
Super-classes obo:TXPO_0001300c
obo:TXPO_0001717c
Restrictions obo:BFO_0000051op some obo:TXPO_0002546c
obo:BFO_0000051op some obo:TXPO_0002760c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002384c
obo:TXPO_0000069op some obo:TXPO_0000413c
Sub-classes obo:TXPO_0002760c
obo:TXPO_0002546c

increasing vomume of bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002717
Super-classes obo:TXPO_0000139c
Sub-classes obo:TXPO_0002662c

hyperfunction of protein unfoldingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002718
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0042026c
Sub-classes obo:TXPO_0002504c
obo:TXPO_0002502c

hyperfunction of moving phenobarbital to the inside of liver [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002719
Super-classes obo:TXPO_0002600c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001719c
obo:TXPO_0000069op some obo:TXPO_0001840c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003876c

rosiglitazone [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002720
Super-classes obo:TXPO_0000749c
obo:CHEBI_50122c

ATF4 gene expression by eIF2a [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002721
Super-classes obo:TXPO_0000707c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002722c
obo:TXPO_0001868op some obo:TXPO_0000829c
obo:TXPO_0000069op some obo:TXPO_0002966c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0002558c

Chop expression by ATF4 [ER stress] [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002722
Super-classes obo:TXPO_0000698c
Restrictions obo:RO_0002234op some obo:TXPO_0002915c
obo:TXPO_0001868op some obo:TXPO_0002558c
obo:TXPO_0000069op some obo:TXPO_0002767c

SHP1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002723
Super-classes obo:TXPO_1000358c
obo:TXPO_0000276c

CAR (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002724
Description

Genes encoding for organic anion uptake (NTCP, OATPs), canalicular export (BSEP, MRP2) and alternative basolateral export (MRP3, MRP4) in liver are regulated by hepatocyte nuclear factors (HNF1, 3, 4) and nuclear (orphan) receptors (e.g., FXR, PXR, CAR, RAR, LRH-1, SHP, GR). Bile acids, proinflammatory cytokines, hormones and drugs mediate causative and adaptive transporter changes at a transcriptional level by interacting with these nuclear factors and receptors.
Super-classes obo:TXPO_0000276c
obo:TXPO_0003862c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

GR (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002725
Super-classes obo:TXPO_0003121c
obo:TXPO_0000276c

PXR (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002726
Super-classes obo:TXPO_0000276c
obo:OGG_3000008856c
obo:TXPO_0003120c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

ubiquitination of IkBc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002727
Super-classes obo:TXPO_0004096c
Sub-classes obo:TXPO_0002809c
obo:TXPO_0002777c

PERK - signaling factor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002728
Super-classes obo:TXPO_0002119c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002440c

PERK - signaling factor (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002729
Super-classes obo:TXPO_0002119c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002412c
obo:TXPO_0000774op only obo:TXPO_0000413c

PERK - signal sensor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002730
Super-classes obo:TXPO_0001841c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002731c
obo:RO_0000087op some obo:TXPO_0000882c

receiving abnormal protein signal by PERK [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002731
Super-classes obo:TXPO_0002741c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002440c
obo:TXPO_0001868op some obo:TXPO_0002730c
obo:TXPO_0000012op some obo:TXPO_0001839c

positive regulation of bile exportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002732
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:TXPO_0002683c
Sub-classes obo:TXPO_0002645c

negative regulation of bile acid and bile salts export from the hepatocyte to bile tube [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002733
Super-classes obo:TXPO_0001892c
obo:TXPO_0000889c
Restrictions obo:RO_0002212op some obo:TXPO_0002692c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001190c

cholestasis [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002734
Super-classes obo:TXPO_0001345c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

PERK-Nrf2 mediated pathway (integrated pathway)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002735
Super-classes obo:TXPO_0000067c
Restrictions obo:BFO_0000051op some obo:TXPO_0002764c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:BFO_0000051op some obo:TXPO_0002736c
obo:BFO_0000051op some obo:TXPO_0001837c
obo:BFO_0000051op some obo:TXPO_0002742c
obo:TXPO_0002524op some obo:TXPO_0002490c
Sub-classes obo:TXPO_0002740c

NRF2 activation by PERK [PERK - NRF2 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002736
Super-classes obo:TXPO_0001370c
obo:TXPO_0001861c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002737c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002739c

dissociation of Nrf2-Keap1 complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002737
Super-classes obo:TXPO_0000462c
Sub-classes obo:TXPO_0002366c
obo:TXPO_0002738c

dissociation of Nrf2-Keap1 complex by PERK [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002738
Super-classes obo:TXPO_0003736c
obo:TXPO_0002737c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

NRF2 activation by PERK [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002739
Super-classes obo:TXPO_0002736c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002738c
obo:TXPO_0000069op some obo:TXPO_0002744c
obo:TXPO_0000774op only obo:TXPO_0002528c

PERK-Nrf2 mediated pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002740
Super-classes obo:TXPO_0002735c
Restrictions obo:BFO_0000051op some obo:TXPO_0002750c
obo:BFO_0000051op some obo:TXPO_0002765c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:BFO_0000051op some obo:TXPO_0002749c
obo:BFO_0000051op some obo:TXPO_0002739c

receiving abnormal protein signal by PERK [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002741
Super-classes obo:TXPO_0001837c
obo:TXPO_0001717c
Restrictions obo:TXPO_0001868op some obo:TXPO_0000301c
obo:TXPO_0000069op some obo:TXPO_0002449c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0001826c
obo:TXPO_0002992c
obo:TXPO_0000123c
obo:TXPO_0002731c
obo:TXPO_0002847c

PERK signaling to Nrf2 [PERK - eIF2A pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002742
Super-classes obo:TXPO_0000454c
Restrictions obo:BFO_0000051op some obo:TXPO_0002736c
obo:TXPO_0002524op some obo:TXPO_0002490c
Sub-classes obo:TXPO_0002743c

PERK signaling to Nrf2 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002743
Super-classes obo:TXPO_0002742c
Restrictions obo:BFO_0000051op some obo:TXPO_0002739c

antioxidant gene expression by NRF2 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002744
Super-classes obo:TXPO_0002618c
Restrictions obo:BFO_0000051op some obo:TXPO_0002739c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0002740c
obo:TXPO_0001868op some obo:TXPO_0002745c
obo:BFO_0000051op some obo:TXPO_0002749c
obo:BFO_0000051op some obo:TXPO_0002750c

NRF2 - transcriptional regulator (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002745
Super-classes obo:TXPO_0000047c
Restrictions obo:RO_0000087op some obo:CHEBI_22586c
obo:TXPO_0001896op some obo:TXPO_0002744c
obo:RO_0000087op some obo:TXPO_0003645c

positive regulation of cellular response to oxidative stress [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002746
Super-classes obo:GO_1900409c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002747c
obo:BFO_0000051op some obo:TXPO_0002618c

oxidation-antioxidtion inbalance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002747
Super-classes obo:TXPO_0002748c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

oxidation-antioxidtion inbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002748
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0002747c
obo:TXPO_0003177c
obo:TXPO_0000461c

receiving oxidative signal by PERK [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002749
Super-classes obo:TXPO_0001837c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002743c

PERK activation [ER stress - antioxidation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002750
Super-classes obo:TXPO_0000402c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002739c

enabling translation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002751
Description

This entity refers to the process of restarting translation. During protein refolding, it is known that a translation attenuation is occurred temporarily to reduce the production of new proteins.
Super-classes obo:TXPO_0002617c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0003058c
obo:BFO_0000051op some obo:TXPO_0002752c
obo:TXPO_0000069op some obo:TXPO_0002716c
obo:BFO_0000051op some obo:TXPO_0003054c

dephosphorylation of eIF2a [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002752
Super-classes obo:GO_0016311c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0002932c
obo:TXPO_0001868op some obo:TXPO_0002935c
obo:RO_0002233op some obo:TXPO_0002931c

gene expression patheway dependent moleculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002753
Super-classes obo:TXPO_0001820c

eIF2a gene regulation pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002754
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0002755c
obo:BFO_0000051op some obo:TXPO_0002757c

regulation of translation by eIF2a [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002755
Super-classes obo:TXPO_0002874c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001275c
Sub-classes obo:TXPO_0002762c

positive regulation of uORF dependent gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002756
Super-classes obo:GO_0010628c
Sub-classes obo:TXPO_0002757c

positive regulation of uORF dependent gene expression [eIF2a [translation regulation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002757
Super-classes obo:TXPO_0002756c

degradation of I-kappaBc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002758
Super-classes obo:GO_0030163c
Sub-classes obo:TXPO_0002778c
obo:TXPO_0002810c

Bile acid accumulation in hepatocyte [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002759
Super-classes obo:TXPO_0000263c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002734c
obo:TXPO_0000774op only obo:TXPO_0000501c

refolding promoting gene expression by XBP1s [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002760
Super-classes obo:TXPO_0002716c
obo:TXPO_0003736c
Restrictions obo:BFO_0000051op some obo:TXPO_0002919c
obo:TXPO_0002524op some obo:TXPO_0002609c
obo:BFO_0000051op some obo:TXPO_0000721c
obo:BFO_0000051op some obo:TXPO_0002957c
obo:TXPO_0000774op only obo:TXPO_0002528c

IRE1 signaling to XBP1 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002761
Super-classes obo:TXPO_0002571c
Restrictions obo:BFO_0000051op some obo:TXPO_0002686c
obo:BFO_0000051op some obo:TXPO_0002689c
obo:TXPO_0000774op only obo:TXPO_0000413c

regulation of translation by eIF2a [ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002762
Super-classes obo:TXPO_0001717c
obo:TXPO_0003736c
obo:TXPO_0002755c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0000416c
obo:TXPO_0001868op some obo:TXPO_0001275c

gene expression by NRF2c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002763
Super-classes obo:TXPO_0000375c
Sub-classes obo:TXPO_0002764c

gene expression by NRF2 [PERK - NRF2 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002764
Super-classes obo:TXPO_0002763c
Sub-classes obo:TXPO_0002765c

gene expression by NRF2 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002765
Super-classes obo:TXPO_0002764c

inflammatory cytokine gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002766
Super-classes obo:TXPO_0001717c
obo:TXPO_0002266c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002599c
obo:TXPO_0002524op some obo:TXPO_0002794c
obo:TXPO_0002524op some obo:TXPO_0002796c
obo:BFO_0000051op some obo:TXPO_0002829c
obo:BFO_0000051op some obo:TXPO_0002843c
obo:BFO_0000051op some obo:TXPO_0002830c
obo:TXPO_0002524op some obo:TXPO_0002795c
obo:BFO_0000051op some obo:TXPO_0002811c
obo:TXPO_0000069op some obo:TXPO_0000760c
obo:BFO_0000051op some obo:TXPO_0002805c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0002836c
obo:TXPO_0002524op some obo:TXPO_0002624c
obo:BFO_0000051op some obo:TXPO_0003043c

gene expression by CHOP (DDIT3, GADD153) [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002767
Super-classes obo:TXPO_0001874c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002916c
obo:TXPO_0001868op some obo:TXPO_0002915c
obo:TXPO_0001868op some obo:TXPO_0002167c
obo:TXPO_0001868op some obo:TXPO_0000791c

NFKB - transcriptional regulator (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002768
Super-classes obo:TXPO_0002769c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0000774op only obo:TXPO_0000760c

NFKB (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002769
Super-classes obo:TXPO_0000871c
obo:TXPO_1000258c
Restrictions obo:TXPO_0002260op some obo:IMR_0000382c
obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:TXPO_0002768c

gene expression bu NF-kappaBc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002770
Super-classes obo:TXPO_0000375c
Sub-classes obo:TXPO_0002775c

PDI (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002771
Super-classes obo:TXPO_0000871c
obo:TXPO_1000276c

I-kappaB phosphorylation [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002772
Super-classes obo:TXPO_0002495c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002777c

XBP1 splicing [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002773
Super-classes obo:TXPO_0000726c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

NfkB gene regulation pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002774
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0002770c

inflammatory gene expression by NF-kappa B [ER stress - inflammation - IRE1-TRAF-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002775
Super-classes obo:TXPO_0001717c
obo:TXPO_0002770c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:TXPO_0001868op some obo:TXPO_0002768c

ERDJ5 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002776
Super-classes obo:TXPO_1000127c
obo:TXPO_0000871c

ubiquitination of IkB [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002777
Super-classes obo:TXPO_0002727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002810c

degradation of IKB [NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002778
Super-classes obo:TXPO_0002758c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002779c

Translocation of NF-kappaB [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002779
Super-classes obo:HINO_0017769c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002785c
obo:RO_0002234op some obo:TXPO_0002769c
Sub-classes obo:TXPO_0002633c

IKK activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002780
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0002781c

IKK activation [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002781
Super-classes obo:TXPO_0002780c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002783c
Sub-classes obo:TXPO_0002817c

NF-kappaB activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002782
Super-classes obo:TXPO_0000124c
Restrictions obo:RO_0002233op only obo:IMR_0000382c
Sub-classes obo:TXPO_0002807c
obo:TXPO_0002798c
obo:TXPO_0002783c
obo:TXPO_0002841c

NF-kappaB activation [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002783
Super-classes obo:TXPO_0002782c
Restrictions obo:BFO_0000051op some obo:TXPO_0002791c
obo:TXPO_0000069op some obo:TXPO_0002779c

regulation of gene expression by NfKBc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002784
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0002840c
obo:TXPO_0002813c
obo:TXPO_0002785c
obo:TXPO_0002812c

regulation of gene expression by NfKB [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002785
Super-classes obo:TXPO_0002784c

Binding of NF-kappaB and I-kappaB in cytosolc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002786
Super-classes obo:GO_0005515c
Sub-classes obo:TXPO_0002790c

ABCC4 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002787
Super-classes obo:TXPO_0003019c
obo:TXPO_0002045c

forming disulfide bond 2 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002788
Super-classes obo:TXPO_0002118c
obo:TXPO_0001717c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002771c
obo:RO_0000057op some obo:TXPO_0000805c
obo:RO_0000057op some obo:TXPO_0002497c
obo:TXPO_0000774op only obo:TXPO_0002528c

cytoplasmic sequestering of NF-kappaB [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002789
Super-classes obo:GO_0007253c
Restrictions obo:BFO_0000051op some obo:TXPO_0002790c

Binding of NF-kappaB and I-kappaB in cytosol [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002790
Super-classes obo:TXPO_0002786c

dissociation of NF-kappaB - IkappaB [NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002791
Super-classes obo:TXPO_0002492c
Restrictions obo:BFO_0000051op some obo:TXPO_0002778c
obo:BFO_0000051op some obo:TXPO_0002777c
obo:BFO_0000051op some obo:TXPO_0002808c

ABCC5 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002792
Super-classes obo:TXPO_0003018c
obo:TXPO_0002045c

PERK-NFkB pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002793
Super-classes obo:TXPO_0000067c
Restrictions obo:BFO_0000051op some obo:TXPO_0002783c
obo:BFO_0000051op some obo:TXPO_0002779c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:BFO_0000051op some obo:TXPO_0002785c
obo:TXPO_0000774op only obo:TXPO_0000760c
obo:BFO_0000051op some obo:TXPO_0002789c

PERK-eIF2a-NFkB pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002794
Super-classes obo:TXPO_0000701c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002797c
obo:BFO_0000051op some obo:TXPO_0002853c
obo:BFO_0000051op some obo:TXPO_0002798c
obo:BFO_0000051op some obo:TXPO_0002814c
obo:BFO_0000051op some obo:TXPO_0002812c

IRE1-TRAF2-NFkB signal transduction pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002795
Super-classes obo:TXPO_0002563c
Restrictions obo:TXPO_0002524op some obo:GO_0007249c
obo:BFO_0000051op some obo:TXPO_0002816c
obo:TXPO_0002524op some obo:TXPO_0002879c
obo:BFO_0000051op some obo:TXPO_0002813c
obo:BFO_0000051op some obo:TXPO_0002815c
obo:BFO_0000051op some obo:TXPO_0002817c
obo:BFO_0000051op some obo:TXPO_0002807c

ATF6-NFkB signal transduction pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002796
Super-classes obo:TXPO_0002548c
Restrictions obo:BFO_0000051op some obo:TXPO_0002837c
obo:BFO_0000051op some obo:TXPO_0002840c
obo:TXPO_0002524op some obo:GO_0007249c
obo:BFO_0000051op some obo:TXPO_0002838c
obo:BFO_0000051op some obo:TXPO_0002841c
obo:TXPO_0002524op some obo:TXPO_0002126c

PERK-eIF2a signaling [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002797
Super-classes obo:TXPO_0000701c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000722c
obo:BFO_0000051op some obo:TXPO_0002849c
obo:BFO_0000051op some obo:TXPO_0002847c
obo:BFO_0000051op some obo:TXPO_0002853c

NF-kappaB activation [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002798
Description

CHOP Knock Down resulted in reduced cytokine-induced NF-κB activity and expression of key NF-κB target genes involved in apoptosis and inflammation, including iNOS, FAS, IRF-7, IL-15, CCL5 and CXCL10. This was due to decreased IκB degradation and p65 translocation to the nucleus
Super-classes obo:TXPO_0003736c
obo:TXPO_0002782c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002814c
obo:TXPO_0000774op only obo:TXPO_0002528c

decreasing I-kappaB productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002799
Super-classes obo:TXPO_0001830c
Sub-classes obo:TXPO_0002842c
obo:TXPO_0002800c

decreasing I-kappaB production [ER stress - inflammation -Perk-eIF2a-NfkB]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002800
Super-classes obo:TXPO_0002799c

I-kappaB -NfkB inhibitor [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002801
Super-classes obo:TXPO_0002802c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:TXPO_0002260op some obo:IMR_0000464c
obo:RO_0000087op some obo:CHEBI_73240c

IKBc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002802
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003720c
obo:TXPO_0002260op some obo:IMR_0000464c
Sub-classes obo:TXPO_0002801c

cation channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002803
Super-classes obo:TXPO_0000328c
Sub-classes obo:TXPO_0003656c
obo:TXPO_0003161c
obo:TXPO_0003655c

Translocation of NF-kappaB [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002804
Super-classes obo:TXPO_0002633c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002805c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0002768c

inflammatory cytokine gene expression by NF-kappa B via PERK [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002805
Super-classes obo:TXPO_0002266c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002766c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0002794c

inflammatory cytokine gene expression via JNK [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002806
Super-classes obo:TXPO_0001717c
obo:TXPO_0002266c
Restrictions obo:BFO_0000051op some obo:TXPO_0002833c
obo:BFO_0000051op some obo:TXPO_0002888c
obo:BFO_0000051op some obo:TXPO_0002823c
obo:BFO_0000051op some obo:TXPO_0002835c
obo:TXPO_0002524op some obo:TXPO_0002599c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002829c
obo:BFO_0000051op some obo:TXPO_0002827c

NF-kappaB activation [ER stress - inflammation - IRE1-TRAF2-IkB-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002807
Super-classes obo:TXPO_0002782c
obo:TXPO_0003736c
Restrictions obo:BFO_0000051op some obo:TXPO_0002791c
obo:TXPO_0000069op some obo:TXPO_0002815c
obo:TXPO_0000774op only obo:TXPO_0002528c

I-kappaB phosphorylation [ER stress - inflammation - IRE1-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002808
Super-classes obo:TXPO_0002495c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002777c

ubiquitination of IkB [ER stress - inflammation - IRE1-NfKB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002809
Super-classes obo:TXPO_0002727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002810c

degradation of I-kappaB [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002810
Super-classes obo:TXPO_0002758c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002815c

inflammatory cytokine gene expression by NF-kappa B via IRE1 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002811
Super-classes obo:TXPO_0001717c
obo:TXPO_0002266c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002795c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002766c

regulation of gene expression by NfKB [ER stress - inflammation - PERK-eIF2a-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002812
Super-classes obo:TXPO_0002784c
Restrictions obo:BFO_0000051op some obo:TXPO_0002805c

regulation of gene expression by NfKB [ER stress - inflammation - IRE1-Traf2-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002813
Super-classes obo:TXPO_0002784c
Restrictions obo:BFO_0000051op some obo:TXPO_0002811c

Translocation of NF-kappaB from the Cytosol to the Nucleus [ER stress - inflammation - Perk-eIF2a-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002814
Super-classes obo:TXPO_0002633c
Restrictions obo:RO_0002234op some obo:TXPO_0002768c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002805c

Translocation of NF-kappaB from the Cytosol to the Nucleus [ER stress - inflammation - IRE1-TRAF2-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002815
Super-classes obo:TXPO_0002633c
Restrictions obo:RO_0002234op some obo:TXPO_0002768c
obo:TXPO_0000069op some obo:TXPO_0002805c
obo:TXPO_0000774op only obo:TXPO_0002528c

TRAF2 activation by IRE1 [ER stress - inflammation - IRE1-TRAF2-IKK-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002816
Super-classes obo:TXPO_0002820c
Restrictions obo:RO_0002234op some obo:TXPO_0002819c
obo:TXPO_0000069op some obo:TXPO_0002817c

IKK activation [ER stress - inflammation - IRE1-TRAF2-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002817
Super-classes obo:TXPO_0002781c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002818c
obo:TXPO_0000069op some obo:TXPO_0002807c

TRAF2 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002818
Super-classes obo:IMR_0100423c
obo:TXPO_0000871c
Restrictions obo:TXPO_0002260op some obo:IMR_0000462c
Sub-classes obo:TXPO_0002938c
obo:TXPO_0002822c
obo:TXPO_0002819c

TRAF2 -IRE1 adaptor protein (canonical)[ER stress - inflammation -IRE1-NfkB]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002819
Super-classes obo:TXPO_0002818c
Restrictions obo:TXPO_0002260op some obo:IMR_0000462c
obo:RO_0000087op some obo:TXPO_0003657c

TRAF2 activation by IRE1 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002820
Super-classes obo:TXPO_0002872c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002817c
obo:RO_0002234op some obo:TXPO_0002819c
Sub-classes obo:TXPO_0002821c
obo:TXPO_0002816c
obo:TXPO_0002937c

TRAF2 activation by IRE1 [ER stress - inflammation - IRE1-TRAF2-ASK-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002821
Super-classes obo:TXPO_0002820c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002823c
obo:TXPO_0001868op some obo:TXPO_0002894c
obo:RO_0002234op some obo:TXPO_0002822c

TRAF2 -IRE1 adaptor protein (canonical)[ER stress - inflammation -IRE1-JNK]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002822
Super-classes obo:TXPO_0002818c
Restrictions obo:RO_0000087op some obo:TXPO_0003657c
obo:TXPO_0002260op some obo:IMR_0000462c

ASK activation [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002823
Super-classes obo:TXPO_0002824c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002827c
obo:TXPO_0001868op some obo:TXPO_0002822c

ASK activation [IRE-TRAF2-ASK-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002824
Super-classes obo:TXPO_0002825c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002826c
Sub-classes obo:TXPO_0002823c
obo:TXPO_0002939c

ASK activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002825
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0002824c

JNK activation [JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002826
Super-classes obo:TXPO_0002828c

JNK activation [ER stress - inflammation - IRE1-TRAF2-ASK-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002827
Super-classes obo:TXPO_0003736c
obo:TXPO_0002828c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002829c
obo:TXPO_0000774op only obo:TXPO_0002528c

JNK activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002828
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0001527c
obo:TXPO_0002940c
obo:TXPO_0002827c
obo:TXPO_0002826c

AP-1 activation by JNK [ER stress - inflammation - IRE1-TRAF2-ASK-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002829
Super-classes obo:TXPO_0001321c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002833c

inflammatory cytokine gene expression by XBP1s [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002830
Super-classes obo:TXPO_0002266c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002766c

IRE1 signaling to XBP1 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002831
Super-classes obo:TXPO_0002571c
Restrictions obo:BFO_0000051op some obo:TXPO_0002832c
obo:TXPO_0000774op only obo:TXPO_0000760c
obo:BFO_0000051op some obo:TXPO_0002688c

XBP1 activation by IRE1 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002832
Description

The XBP1 gene is transcribed to yield mRNA, the mRNA is spliced to yield Xbp(s) mRNA, and the mRNA is translated to yield protein.
Super-classes obo:TXPO_0002690c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002773c
obo:TXPO_0000069op some obo:TXPO_0002830c

inflammatory cytokine gene expression by AP-1 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002833
Super-classes obo:TXPO_0002266c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002766c
obo:TXPO_0000774op only obo:TXPO_0002528c

IRE1 signaling to TRAF2 [ER stress - inflammation - IRE1-TRAF2-IKK-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002834
Super-classes obo:TXPO_0002594c
Restrictions obo:BFO_0000051op some obo:TXPO_0002816c

IRE1 signaling to TRAF2 [ER stress - inflammation - IRE1-TRAF2-ASK-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002835
Super-classes obo:TXPO_0002594c
Restrictions obo:BFO_0000051op some obo:TXPO_0002821c
obo:TXPO_0000069op some obo:TXPO_0002827c
obo:BFO_0000051op some obo:TXPO_0002823c
obo:TXPO_0000069op some obo:TXPO_0002823c

IRE1-XBP1 mediated pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002836
Super-classes obo:TXPO_0002563c
Restrictions obo:BFO_0000051op some obo:TXPO_0002830c
obo:TXPO_0002524op some obo:TXPO_0002155c
obo:TXPO_0002524op some obo:TXPO_0002486c
obo:BFO_0000051op some obo:TXPO_0002831c
obo:BFO_0000051op some obo:TXPO_0002832c

Translocation of NF-kappaB from the Cytosol to the Nucleus [ER stress - inflammation - ATF6-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002837
Super-classes obo:TXPO_0002633c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002805c
obo:RO_0002234op some obo:TXPO_0002768c
obo:TXPO_0000774op only obo:TXPO_0002528c

ATF6 signaling (primitive) [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002838
Super-classes obo:TXPO_0000719c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002841c
obo:TXPO_0000774op only obo:TXPO_0000760c
obo:BFO_0000051op some obo:TXPO_0002924c
obo:TXPO_0001868op some obo:TXPO_0002902c
Sub-classes obo:TXPO_0003072c
obo:TXPO_0002844c

PERK - stress sensor (canonical)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002839
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000087op some obo:TXPO_0000881c
obo:RO_0000056op some obo:TXPO_0000123c

regulation of gene expression by NfKB [ER stress - inflammation - ATF6-NfkB Pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002840
Super-classes obo:TXPO_0002784c
Restrictions obo:BFO_0000051op some obo:TXPO_0002843c

NF-kappaB activation [ER stress - inflammation - ATF6-NfkB]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002841
Super-classes obo:TXPO_0003736c
obo:TXPO_0002782c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002837c
obo:TXPO_0000774op only obo:TXPO_0002528c

decreasing I-kappaB production [ER stress -inflmmation- ATF6-NfkB]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002842
Super-classes obo:TXPO_0002799c

inflammatory cytokine gene expression by NF-kappa B via ATF6 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002843
Super-classes obo:TXPO_0002266c
obo:TXPO_0000055c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002796c
obo:TXPO_0000069op some obo:TXPO_0002766c
obo:TXPO_0000774op only obo:TXPO_0002528c

ATF6 signaling (primitive) [ER stress - inflammation - ATF6-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002844
Super-classes obo:TXPO_0002838c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002796c
obo:TXPO_0000069op some obo:TXPO_0002843c
obo:TXPO_0000774op only obo:TXPO_0000760c
obo:TXPO_0001868op some obo:TXPO_0002902c

PERK - stress sensor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002845
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000087op some obo:TXPO_0000881c
obo:RO_0000056op some obo:TXPO_0002731c

PERK - stress sensor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002846
Super-classes obo:TXPO_0000878c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:RO_0000056op some obo:TXPO_0002847c
obo:RO_0000087op some obo:TXPO_0000881c

receiving abnormal protein signal by PERK [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002847
Super-classes obo:TXPO_0001717c
obo:TXPO_0002741c
Restrictions obo:TXPO_0000012op some obo:TXPO_0000463c
obo:TXPO_0000069op some obo:TXPO_0002849c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002848c

PERK - signal sensor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002848
Super-classes obo:TXPO_0001841c
Restrictions obo:RO_0000087op some obo:TXPO_0000882c
obo:TXPO_0001896op some obo:TXPO_0002847c
obo:TXPO_0000774op only obo:TXPO_0000760c

PERK signaling to eIF2a [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002849
Super-classes obo:TXPO_0002449c
obo:TXPO_0001717c
Restrictions obo:RO_0000057op some obo:TXPO_0002850c
obo:TXPO_0000069op some obo:TXPO_0002853c
obo:BFO_0000051op some obo:TXPO_0002852c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002854c

PERK - signaling factor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002850
Super-classes obo:TXPO_0002119c
Restrictions obo:TXPO_0001896op some obo:TXPO_0000061c
obo:TXPO_0000774op only obo:TXPO_0000760c

XBP1 splicing [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002851
Super-classes obo:TXPO_0000726c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

changing activity of eIF2a by PERK [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002852
Super-classes obo:TXPO_0002378c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002853c
obo:TXPO_0000012op some obo:TXPO_0002510c

attenuation of I-kappaB translation by eIF2a [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002853
Super-classes obo:TXPO_0000722c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002896c
obo:TXPO_0000069op some obo:TXPO_0002798c
obo:BFO_0000051op some obo:TXPO_0002988c

PERK activation [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002854
Super-classes obo:TXPO_0000402c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002855c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002868c
obo:TXPO_0000069op some obo:TXPO_0002852c

PERK dimerization [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002855
Super-classes obo:TXPO_0000713c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002868c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0002882c

PERK - kinase (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002856
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0002510c

PERK - kinase (canonical)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002857
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0002507c

PERK - autophosphorylation kinase (canonical)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002858
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0000388c

PERK - autophosphorylation kinase (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002859
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0002868c
obo:TXPO_0000774op only obo:TXPO_0000760c

PERK - autophosphorylation kinase (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002860
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0002869c

PERK - autophosphorylation kinase (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002861
Super-classes obo:TXPO_0000878c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000056op some obo:TXPO_0002870c

PERK - kinase (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002862
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0002509c

PERK - kinase (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002863
Super-classes obo:TXPO_0000878c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000056op some obo:TXPO_0002508c

PERK - stress sensor (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002864
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000087op some obo:TXPO_0000881c
obo:RO_0000056op some obo:TXPO_0001826c
obo:TXPO_0000774op only obo:TXPO_0000413c

Dissociation of PERK:BIP Heterodimer [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002865
Description

PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.
Super-classes obo:TXPO_0002213c
Restrictions obo:RO_0002234op some obo:TXPO_0002846c
obo:RO_0002234op some obo:TXPO_0002905c
obo:TXPO_0000069op some obo:TXPO_0002855c

PERK dimerization [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002866
Super-classes obo:TXPO_0000713c
Restrictions obo:RO_0000057op some obo:TXPO_0002883c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002869c

PERK dimerization [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002867
Super-classes obo:TXPO_0000713c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002870c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0002881c

PERK autophosphorylation [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002868
Super-classes obo:TXPO_0000674c
Restrictions obo:RO_0000057op some obo:TXPO_0002859c
obo:TXPO_0000774op only obo:TXPO_0002528c

PERK autophosphorylation [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002869
Super-classes obo:TXPO_0000674c
Restrictions obo:RO_0000057op some obo:TXPO_0002860c
obo:TXPO_0000774op only obo:TXPO_0002528c

PERK autophosphorylation [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002870
Super-classes obo:TXPO_0000674c
Restrictions obo:RO_0000057op some obo:TXPO_0002861c
obo:TXPO_0000774op only obo:TXPO_0002528c

XBP1 splicing [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002871
Super-classes obo:TXPO_0000726c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0001968c

TRAF2 activation by IRE1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002872
Super-classes obo:TXPO_0003736c
obo:TXPO_0000023c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002817c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0002819c
Sub-classes obo:TXPO_0002820c

chronicc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002873
Super-classes obo:PATO_0001309c

regulation of translation by eIF2ac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002874
Super-classes obo:GO_0006417c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001275c
Sub-classes obo:TXPO_0002755c

IRE1 pathway [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002875
Super-classes obo:TXPO_0002487c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002155c
obo:BFO_0000051op some obo:TXPO_0002953c
obo:BFO_0000051op some obo:GO_0010468c
obo:BFO_0000051op some obo:TXPO_0002926c

IRE1 pathway [ER stress - inflammation - IRE1-XBP1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002876
Super-classes obo:TXPO_0002487c
Restrictions obo:BFO_0000051op some obo:TXPO_0002895c
obo:BFO_0000051op some obo:GO_0010468c
obo:TXPO_0002524op some obo:TXPO_0002155c
obo:BFO_0000051op some obo:TXPO_0002831c

IRE1 pathway [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002877
Super-classes obo:TXPO_0002487c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002155c
obo:BFO_0000051op some obo:GO_0010468c
obo:BFO_0000051op some obo:TXPO_0002709c
obo:BFO_0000051op some obo:TXPO_0002710c

IRE1 pathway [ER stress - inflammation - IRE1-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002878
Super-classes obo:TXPO_0002487c
Restrictions obo:BFO_0000051op some obo:TXPO_0002835c
obo:BFO_0000051op some obo:GO_0010468c
obo:TXPO_0002524op some obo:TXPO_0002155c
obo:BFO_0000051op some obo:TXPO_0002888c

IRE1 pathway [ER stress - inflammation - IRE1-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002879
Super-classes obo:TXPO_0002487c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002155c
obo:BFO_0000051op some obo:GO_0010468c
obo:BFO_0000051op some obo:TXPO_0002834c
obo:BFO_0000051op some obo:TXPO_0002889c

PERK dimer (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002880
Super-classes obo:TXPO_0001792c
obo:TXPO_0000871c
Restrictions obo:RO_0000056op some obo:TXPO_0000713c
Sub-classes obo:TXPO_0002883c
obo:TXPO_0002881c
obo:TXPO_0002884c
obo:TXPO_0003005c
obo:TXPO_0002882c

PERK dimer (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002881
Super-classes obo:TXPO_0002880c
Restrictions obo:RO_0000056op some obo:TXPO_0002867c
obo:TXPO_0000774op only obo:TXPO_0000413c

PERK dimer (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002882
Super-classes obo:TXPO_0002880c
Restrictions obo:RO_0000056op some obo:TXPO_0002855c
obo:TXPO_0000774op only obo:TXPO_0000760c

PERK dimer (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002883
Super-classes obo:TXPO_0002880c
Restrictions obo:RO_0000056op some obo:TXPO_0002866c

PERK dimer (canonical)[ER stress - translation attenuation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002884
Super-classes obo:TXPO_0002880c
Restrictions obo:RO_0000056op some obo:TXPO_0000063c

Dissociation of IRE1:BIP Heterodimer [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002885
Super-classes obo:TXPO_0002176c
Restrictions obo:RO_0002233op some obo:TXPO_0002111c
obo:RO_0002234op some obo:TXPO_0002846c
obo:RO_0002234op some obo:TXPO_0002907c
obo:TXPO_0000069op some obo:TXPO_0002855c

IRE - stress sensor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002886
Super-classes obo:TXPO_0002602c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:RO_0000087op some obo:TXPO_0000881c
obo:RO_0000056op some obo:TXPO_0002710c

receiving abnormal protein signal by IRE1 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002887
Super-classes obo:TXPO_0003736c
obo:TXPO_0002604c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002602c
obo:TXPO_0000069op some obo:TXPO_0002594c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002885c
Sub-classes obo:TXPO_0002895c
obo:TXPO_0002889c
obo:TXPO_0002888c

receiving abnormal protein signal by IRE1 [ER stress - inflammation - IRE1-TRAF2-ASK-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002888
Super-classes obo:TXPO_0002887c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002602c
obo:TXPO_0000069op some obo:TXPO_0002835c
obo:TXPO_0000774op only obo:TXPO_0002528c

receiving abnormal protein signal by IRE1 [ER stress - inflammation - IRE1-TRAF2-IKK-NfkB pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002889
Super-classes obo:TXPO_0002887c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002834c
obo:TXPO_0001868op some obo:TXPO_0002602c
obo:TXPO_0000774op only obo:TXPO_0002528c

IRE1 - signal sensor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002890
Super-classes obo:TXPO_0002602c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:RO_0000056op some obo:TXPO_0002887c
obo:RO_0000087op some obo:TXPO_0000882c

IRE1 - signaling factor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002891
Super-classes obo:TXPO_0002603c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002594c
obo:RO_0000087op some obo:TXPO_0001898c
Sub-classes obo:TXPO_0002893c
obo:TXPO_0002894c

IRE1 - signaling factor (canonical)[ER stress -ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002892
Super-classes obo:TXPO_0002603c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0001896op some obo:TXPO_0002709c

IRE1 - signaling factor (canonical)[ER stress - inflammation -Xbp1]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002893
Super-classes obo:TXPO_0002891c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0001896op some obo:TXPO_0002831c

IRE1 - signaling factor (canonical)[ER stress - inflammation -TRAF2]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002894
Super-classes obo:TXPO_0002891c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002594c
obo:RO_0000087op some obo:TXPO_0001898c

receiving abnormal protein signal by IRE1 [ER stress - inflammation - IRE1-XBP1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002895
Super-classes obo:TXPO_0002887c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002831c
obo:TXPO_0001868op some obo:TXPO_0002890c
obo:TXPO_0000774op only obo:TXPO_0002528c

P-EIF2A - translation initiation inhibitor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002896
Super-classes obo:TXPO_0000829c
Restrictions obo:RO_0000087op some obo:TXPO_0001909c
obo:TXPO_0000774op only obo:TXPO_0000760c

CALRETICULIN (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002897
Super-classes obo:TXPO_0000871c
obo:TXPO_1000435c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c
obo:RO_0000056op some obo:TXPO_0000413c
Sub-classes obo:TXPO_0002898c

CALRETICULIN - chaperone (canonical)[ER stress -Refolding [persist]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002898
Super-classes obo:TXPO_0002897c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000087op some obo:TXPO_0003997c
obo:RO_0000056op some obo:TXPO_0002393c

ATF6 - transcriptional factor (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002899
Super-classes obo:TXPO_0002468c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000056op some obo:TXPO_0002175c
obo:TXPO_0002260op some obo:IMR_0000825c

ATF6 - stress sensor (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002900
Super-classes obo:TXPO_0000879c
Restrictions obo:TXPO_0002260op some obo:IMR_0000825c
obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000087op some obo:TXPO_0000881c
obo:RO_0000056op some obo:TXPO_0002447c

ATF6 - signaling factor (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002901
Super-classes obo:TXPO_0000044c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0000774op only obo:TXPO_0000413c
obo:TXPO_0000043op some obo:GO_0005794c
obo:RO_0000056op some obo:TXPO_0001905c

ATF6 - signaling factor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002902
Super-classes obo:TXPO_0000044c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0000043op some obo:GO_0005794c
obo:RO_0000056op some obo:TXPO_0002924c

Dissociation of ATF6-alpha:BIP Complex [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002903
Super-classes obo:TXPO_0000505c
Restrictions obo:RO_0002234op some obo:TXPO_0003157c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0000879c
obo:TXPO_0000069op some obo:TXPO_0000713c
Sub-classes obo:TXPO_0003031c
obo:TXPO_0002904c

Dissociation of ATF6-alpha:BIP Complex [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002904
Super-classes obo:TXPO_0002903c
Restrictions obo:RO_0002233op some obo:TXPO_0002110c
obo:RO_0002234op some obo:TXPO_0002906c
obo:TXPO_0000069op some obo:TXPO_0001905c
obo:RO_0002234op some obo:TXPO_0002900c

Bip-unfolded protein complex 1 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002905
Super-classes obo:TXPO_0003157c
Restrictions obo:RO_0002180op some obo:TXPO_0002385c
obo:RO_0002180op some obo:TXPO_0002106c

Bip-Unfolded Protein complex 2 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002906
Super-classes obo:TXPO_0003157c
Restrictions obo:RO_0002180op some obo:TXPO_0002385c
obo:RO_0002180op some obo:TXPO_0002106c

Bip-unfolded protein complex 3 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002907
Super-classes obo:TXPO_0003157c
Restrictions obo:RO_0002180op some obo:TXPO_0002106c
obo:RO_0002180op some obo:TXPO_0002385c

ATF6 mediated proapoptic gene production pathway [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002908
Super-classes obo:TXPO_0002548c
Restrictions obo:BFO_0000051op some obo:TXPO_0002912c
obo:TXPO_0002524op some obo:TXPO_0003033c
obo:BFO_0000051op some obo:TXPO_0002909c
obo:BFO_0000051op some obo:TXPO_0003030c

ATF6 signaling (primitive) [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002909
Super-classes obo:TXPO_0000719c
Restrictions obo:BFO_0000051op some obo:TXPO_0002911c
obo:TXPO_0000774op only obo:TXPO_0002114c
obo:TXPO_0000069op some obo:TXPO_0002912c
obo:TXPO_0001868op some obo:TXPO_0002910c

ATF6 - signaling factor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002910
Super-classes obo:TXPO_0000044c
Restrictions obo:RO_0000056op some obo:TXPO_0002911c
obo:TXPO_0000043op some obo:GO_0005794c
obo:RO_0000087op some obo:TXPO_0001898c

ATF6 activation [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002911
Super-classes obo:TXPO_0000710c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0002910c

apoptotic gene expression by ATF6 [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002912
Super-classes obo:TXPO_0002521c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0002915c
obo:TXPO_0001868op some obo:TXPO_0002913c
obo:TXPO_0000069op some obo:TXPO_0002916c

ATF6 - transcriptional factor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002913
Super-classes obo:TXPO_0002468c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0002260op some obo:IMR_0000825c

CHOP (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002914
Super-classes obo:TXPO_1000067c
obo:TXPO_0000871c
Sub-classes obo:TXPO_0002915c

CHOP - apotosis inducing factor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002915
Super-classes obo:TXPO_0002914c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0000774op only obo:TXPO_0002114c

apoptosis promoting gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002916
Super-classes obo:TXPO_0001717c
obo:TXPO_0002917c
Restrictions obo:BFO_0000051op some obo:TXPO_0003030c
obo:TXPO_0002524op some obo:TXPO_0002519c
obo:BFO_0000051op some obo:TXPO_0002912c
obo:BFO_0000051op some obo:TXPO_0002722c
obo:BFO_0000051op some obo:TXPO_0002721c
obo:TXPO_0000069op some obo:TXPO_0002114c
obo:BFO_0000051op some obo:TXPO_0002909c
obo:BFO_0000051op some obo:TXPO_0002767c
obo:TXPO_0002524op some obo:TXPO_0002908c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002440c

apoptosis promoting gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002917
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0002916c

ATF6 activation [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002918
Super-classes obo:TXPO_0000710c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0002958c

refolding gene expression by XBP1 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002919
Super-classes obo:TXPO_0002607c
Restrictions obo:RO_0000057op some obo:TXPO_0002165c
obo:TXPO_0001868op some obo:TXPO_0002923c
obo:RO_0000057op some obo:TXPO_0000783c
obo:RO_0002234op some obo:TXPO_0002920c
obo:TXPO_0000069op some obo:TXPO_0002384c
obo:TXPO_0000774op only obo:TXPO_0000413c
Sub-classes obo:TXPO_0002612c
obo:TXPO_0002611c

HYOU1 - chaperone (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002920
Super-classes obo:TXPO_0002921c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000087op some obo:TXPO_0002922c

HYOU1 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002921
Super-classes obo:TXPO_1000191c
obo:TXPO_0000871c
Sub-classes obo:TXPO_0002920c

co-chaperonec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002922
Super-classes obo:TXPO_0003732c

XBP1 - transcriptional regulator (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002923
Super-classes obo:TXPO_0001968c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:TXPO_0001896op some obo:TXPO_0002919c

ATF6 activation [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002924
Super-classes obo:TXPO_0003736c
obo:TXPO_0000710c
Restrictions obo:RO_0002234op some obo:TXPO_0002902c
Sub-classes obo:TXPO_0003073c

positive regulation of gene expression via JNK signaling [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002925
Super-classes obo:TXPO_0003116c
obo:TXPO_0001717c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001813c
obo:TXPO_0000774op only obo:TXPO_0002528c

receiving abnormal protein signal by IRE1 [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002926
Super-classes obo:TXPO_0003736c
obo:TXPO_0002604c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002953c
obo:TXPO_0001868op some obo:TXPO_0000906c
obo:TXPO_0000774op only obo:TXPO_0002528c

JNK - kinase (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002927
Super-classes obo:TXPO_0001813c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c

JNK - kinase (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002928
Super-classes obo:TXPO_0001813c

JNK - signalling factor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002929
Super-classes obo:TXPO_0001813c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c

JNK - signalling factor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002930
Super-classes obo:TXPO_0001813c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0000774op only obo:TXPO_0000760c

P-EIF2A - translation initiation inhibitor (canonical)[ER stress - translation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002931
Super-classes obo:TXPO_0000829c
Restrictions obo:RO_0000087op some obo:TXPO_0001909c

EIF2A - translation initiation factor (canonical)[ER stress - translation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002932
Super-classes obo:TXPO_0001275c
Restrictions obo:RO_0000087op some obo:TXPO_0002933c

positive regulator role of translational initiationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002933
Super-classes obo:TXPO_0002557c

GADD34 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002934
Super-classes obo:TXPO_0000150c
obo:TXPO_0000871c
Restrictions obo:RO_0000087op some obo:TXPO_0003675c
Sub-classes obo:TXPO_0002935c

GADD34 - phosphatase (canonical)[ER stress - translation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002935
Super-classes obo:TXPO_0002934c

IRE1-Traf2-ASK-JNK-Bcl2 pathway [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002936
Super-classes obo:TXPO_0002563c
Restrictions obo:BFO_0000051op some obo:TXPO_0002937c
obo:BFO_0000051op some obo:TXPO_0002940c
obo:TXPO_0002524op some obo:TXPO_0002875c
obo:BFO_0000051op some obo:TXPO_0002946c
obo:BFO_0000051op some obo:TXPO_0002939c

TRAF2 activation by IRE1 [ER stress - apoptosis - IRE1−TRAF2-ASK-JNK-Bcl2 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002937
Super-classes obo:TXPO_0002820c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002939c
obo:RO_0002234op some obo:TXPO_0002938c
obo:TXPO_0001868op some obo:TXPO_0002941c

TRAF2 -IRE1 adaptor protein (canonical)[ER stress - apotosis -IRE1-JNK]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002938
Super-classes obo:TXPO_0002818c
Restrictions obo:RO_0000087op some obo:TXPO_0003657c
obo:TXPO_0002260op some obo:IMR_0000462c

ASK activation [ER stress - apoptosis - IRE1-TRAF2-ASK-JNK-Bcl2 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002939
Super-classes obo:TXPO_0002824c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002940c
obo:TXPO_0001868op some obo:TXPO_0002938c
obo:RO_0002234op some obo:TXPO_0002945c

JNK activation [ER stress - apoptosis - IRE1−TRAF2-ASK-JNK-Bcl2 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002940
Super-classes obo:TXPO_0003736c
obo:TXPO_0002828c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002946c
obo:TXPO_0000774op only obo:TXPO_0002528c

IRE1 - signaling factor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002941
Super-classes obo:TXPO_0002603c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0001896op some obo:TXPO_0002594c

ASK (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002942
Super-classes obo:TXPO_0000871c
obo:TXPO_1000010c
Sub-classes obo:TXPO_0002944c
obo:TXPO_0002943c
obo:TXPO_0002945c

ASK - signaling factor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002943
Super-classes obo:TXPO_0002942c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c

ASK - signaling factor (canonical)[ER stress - inflammation -TRAF2]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002944
Super-classes obo:TXPO_0002942c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:RO_0000087op some obo:TXPO_0001898c

ASK - signaling factor (canonical)[ER stress - apotosis -TRAF2]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002945
Super-classes obo:TXPO_0002942c
Restrictions obo:RO_0000087op some obo:TXPO_0001898c

Bcl2 inactivation by JNK [ER stress - apoptosis - IRE1-TRAF2-JNK pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002946
Description

Inhibition of anti-apoptotic factor Bcl-2 results in the promotion of apoptosis.
Super-classes obo:TXPO_0002947c
Restrictions obo:BFO_0000051op some obo:TXPO_0002951c
obo:TXPO_0000069op some obo:TXPO_0002948c

Bcl2 inactivation by JNKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002947
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000041c and ub744bL82812C17c)
Sub-classes obo:TXPO_0002946c

BIM activation [ER stress - apoptosis - IRE1−TRAF2-JNK-Bcl2 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002948
Super-classes obo:TXPO_0002949c

BIM activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002949
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:IMR_0100291c and ub744bL82839C17c)
Sub-classes obo:TXPO_0002948c

Bcl2 phosphorylation by JNK [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002950
Description

The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1.
Super-classes obo:TXPO_0002951c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

Bcl2 phosphorylation by JNK [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002951
Super-classes obo:TXPO_0003736c
obo:TXPO_0002952c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0002950c

Bcl2 phosphorylation by JNKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002952
Super-classes obo:TXPO_0001392c
Sub-classes obo:TXPO_0002951c

IRE1 signaling (primitive) [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002953
Super-classes obo:TXPO_0003736c
obo:TXPO_0002571c
Restrictions obo:BFO_0000051op some obo:TXPO_0002687c
obo:TXPO_0000774op only obo:TXPO_0002114c

BIM (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002954
Super-classes obo:TXPO_0002955c
Restrictions obo:RO_0000087op some obo:TXPO_0000327c
obo:TXPO_0002260op some obo:IMR_0100709c

BIM (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002955
Super-classes obo:IMR_0100291c
obo:TXPO_0000871c
Restrictions obo:TXPO_0002260op some obo:IMR_0100709c
obo:RO_0000087op some obo:TXPO_0000327c
Sub-classes obo:TXPO_0002954c

IRE1 pathway [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002956
Super-classes obo:TXPO_0002487c
Restrictions obo:BFO_0000051op some obo:TXPO_0002761c
obo:TXPO_0002524op some obo:TXPO_0002155c
obo:BFO_0000051op some obo:TXPO_0002957c
obo:TXPO_0000774op only obo:TXPO_0000413c

receiving abnormal protein signal by IRE1 [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002957
Super-classes obo:TXPO_0003736c
obo:TXPO_0002604c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002761c
obo:TXPO_0001868op some obo:TXPO_0000824c
obo:TXPO_0000012op some obo:TXPO_0000463c
obo:TXPO_0000774op only obo:TXPO_0002528c

ATF6 - signaling factor (canonical)[ER stress -ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002958
Super-classes obo:TXPO_0000044c
Restrictions obo:TXPO_0000043op some obo:GO_0005794c
obo:RO_0000056op some obo:TXPO_0002918c
obo:RO_0000087op some obo:TXPO_0001898c
obo:TXPO_0000774op only obo:TXPO_0000413c

XBP1s gene regulation pathway [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002959
Super-classes obo:TXPO_0002486c
Restrictions obo:BFO_0000051op some obo:TXPO_0002919c

XBP1s gene regulation pathway [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002960
Super-classes obo:TXPO_0002486c
Restrictions obo:BFO_0000051op some obo:TXPO_0002608c

CHOP gene regulation pathway [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002961
Super-classes obo:TXPO_0002485c
Restrictions obo:BFO_0000051op some obo:TXPO_0002767c

NRF2 gene regulation pathway [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002962
Super-classes obo:TXPO_0002490c
Restrictions obo:BFO_0000051op some obo:TXPO_0002765c

Refolding gene regulation pathway by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002963
Super-classes obo:TXPO_0002483c
Restrictions obo:BFO_0000051op some obo:TXPO_0002964c

refolding gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002964
Super-classes obo:TXPO_0000698c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002965c

ATF4 - transcriptional regulator (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002965
Super-classes obo:TXPO_0001907c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000087op some obo:TXPO_0000330c

apoptotic gene expression by ATF4 [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002966
Super-classes obo:TXPO_0000698c
Restrictions obo:BFO_0000051op some obo:TXPO_0002722c
obo:TXPO_0001868op some obo:TXPO_0002558c
obo:TXPO_0000069op some obo:TXPO_0002916c

carbohydrate metabolism gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002967
Super-classes obo:TXPO_0000698c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002969c
Sub-classes obo:TXPO_0002498c

lipid metabolism gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002968
Super-classes obo:TXPO_0000698c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002970c
obo:TXPO_0000774op only obo:TXPO_0002528c

ATF4 - transcriptional regulator (canonical)[ER stress - glucose metabolism disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002969
Super-classes obo:TXPO_0001907c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

ATF4 - transcriptional regulator (canonical)[ER stress - dyslipidemia]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002970
Super-classes obo:TXPO_0001907c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

IRE1 dimerization [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002971
Super-classes obo:TXPO_0002596c
Restrictions obo:RO_0000057op some obo:TXPO_0002973c
obo:TXPO_0000069op some obo:TXPO_0002976c
obo:TXPO_0000774op only obo:TXPO_0000413c

IRE1 dimer (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002972
Super-classes obo:TXPO_0001528c
obo:TXPO_0000871c
Restrictions obo:RO_0000056op some obo:TXPO_0002596c
Sub-classes obo:TXPO_0002974c
obo:TXPO_0002973c
obo:TXPO_0003090c

IRE1 dimer (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002973
Super-classes obo:TXPO_0002972c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000413c
obo:RO_0000056op some obo:TXPO_0002971c

IRE1 dimer (canonical)[ER stress -ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002974
Super-classes obo:TXPO_0002972c
Restrictions obo:RO_0000056op some obo:TXPO_0002971c

IRE1 dimerization [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002975
Super-classes obo:TXPO_0002596c
Restrictions obo:RO_0000057op some obo:TXPO_0002974c
obo:TXPO_0000069op some obo:TXPO_0002977c
obo:TXPO_0000774op only obo:TXPO_0002528c

IRE1 autophosphorylation [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002976
Super-classes obo:TXPO_0003736c
obo:TXPO_0002598c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0002978c

IRE1 autophosphorylation [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002977
Super-classes obo:TXPO_0002598c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0002979c

IRE1 - autophosphorylation kinase (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002978
Super-classes obo:TXPO_0002601c
Restrictions obo:RO_0000056op some obo:TXPO_0002971c
obo:TXPO_0000774op only obo:TXPO_0000413c

IRE1 - autophosphorylation kinase (canonical)[ER stress -ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002979
Super-classes obo:TXPO_0002601c
Restrictions obo:RO_0000056op some obo:TXPO_0002975c

Translocation of XBP1s from the cytosol to the nucleusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002980
Super-classes obo:GO_0051169c
Restrictions obo:RO_0002338op some obo:GO_0005829c
obo:RO_0002339op some obo:GO_0005634c
Sub-classes obo:TXPO_0002981c

Translocation of XBP1s from the cytosol to the nucleus [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002981
Super-classes obo:TXPO_0002980c
Sub-classes obo:TXPO_0002983c
obo:TXPO_0002982c
obo:TXPO_0002985c

Translocation of XBP1s from the cytosol to the nucleus [ER stress - refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002982
Super-classes obo:TXPO_0002981c
Restrictions obo:BFO_0000051op some obo:TXPO_0002760c
obo:RO_0002234op some obo:TXPO_0002923c
obo:TXPO_0000774op only obo:TXPO_0000413c

Translocation of XBP1s from the cytosol to the nucleus [ER stress - ERAD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002983
Super-classes obo:TXPO_0002981c
Restrictions obo:RO_0002234op some obo:TXPO_0002605c
obo:BFO_0000051op some obo:TXPO_0002696c

XBP1s gene regulation pathway[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002984
Super-classes obo:TXPO_0002486c
Restrictions obo:BFO_0000051op some obo:TXPO_0002830c

Translocation of XBP1s from the cytosol to the nucleus [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002985
Super-classes obo:TXPO_0002981c
Restrictions obo:RO_0002234op some obo:TXPO_0002605c
obo:BFO_0000051op some obo:TXPO_0002830c

PERK-eIF2a-CyclinD1 pathway [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002986
Super-classes obo:TXPO_0000701c
Restrictions obo:BFO_0000051op some obo:TXPO_0002991c
obo:TXPO_0000774op only obo:TXPO_0002116c
obo:BFO_0000051op some obo:TXPO_0002992c
obo:BFO_0000051op some obo:TXPO_0002989c

regulation of cell cycle related gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002987
Super-classes obo:TXPO_0001717c
obo:TXPO_0000183c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

negative regulation of formation of cytoplasmic translation initiation complex by eIF2a [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002988
Super-classes obo:TXPO_0000068c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002555c

attenuation of Cyclin D1 translation by eIF2a [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002989
Super-classes obo:TXPO_0000722c
Restrictions obo:RO_0002233op some obo:TXPO_0003006c
obo:TXPO_0001868op some obo:TXPO_0003588c

negative regulation of cell cycle regulator gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002990
Super-classes obo:TXPO_0003455c
obo:TXPO_0001717c
Restrictions obo:BFO_0000051op some obo:TXPO_0002992c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0002989c
obo:BFO_0000051op some obo:TXPO_0002991c

PERK signaling to eIF2a [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002991
Super-classes obo:TXPO_0002449c
Restrictions obo:BFO_0000051op some obo:TXPO_0003002c
obo:TXPO_0000069op some obo:TXPO_0002989c
obo:BFO_0000051op some obo:TXPO_0003001c
obo:RO_0000057op some obo:TXPO_0003003c
obo:TXPO_0000774op only obo:TXPO_0002528c

receiving abnormal protein signal by PERK [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002992
Super-classes obo:TXPO_0001717c
obo:TXPO_0002741c
Restrictions obo:TXPO_0000012op some obo:TXPO_0002995c
obo:TXPO_0000069op some obo:TXPO_0002991c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0002993c

PERK - signal sensor (canonical)[ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002993
Super-classes obo:TXPO_0001841c
Restrictions obo:RO_0000087op some obo:TXPO_0000882c
obo:TXPO_0001896op some obo:TXPO_0002992c

PERK - signal sensor (canonical)[ER stress - Refolding]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002994
Super-classes obo:TXPO_0001841c
Restrictions obo:RO_0000087op some obo:TXPO_0000882c
obo:TXPO_0000774op only obo:TXPO_0000413c
obo:TXPO_0001896op some obo:TXPO_0000123c

Dissociation of PERK:BIP Heterodimer [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002995
Description

PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.
Super-classes obo:TXPO_0002213c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000063c
obo:RO_0002234op some obo:TXPO_0002996c
obo:RO_0002234op some obo:TXPO_0003157c

PERK - stress sensor (canonical)[ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002996
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000087op some obo:TXPO_0000881c
obo:RO_0000056op some obo:TXPO_0002992c

PERK autophosphorylation [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002997
Super-classes obo:TXPO_0000674c
Restrictions obo:RO_0000057op some obo:TXPO_0002998c
obo:TXPO_0000774op only obo:TXPO_0002528c

PERK - autophosphorylation kinase (canonical)[ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002998
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0002997c

PERK - kinase (canonical)[ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0002999
Super-classes obo:TXPO_0000878c
Restrictions obo:RO_0000056op some obo:TXPO_0003000c

Phosphorylation of eIF2-alpha by PERK [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003000
Description

The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1.
Super-classes obo:TXPO_0000700c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002989c
obo:TXPO_0000774op only obo:TXPO_0002528c

changing activity of eIF2a by PERK [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003001
Super-classes obo:TXPO_0002378c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002507c

PERK activation [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003002
Super-classes obo:TXPO_0000402c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002506c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0002997c
obo:TXPO_0000012op some obo:TXPO_0003004c

PERK - signaling factor (canonical)[ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003003
Super-classes obo:TXPO_0002119c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002991c

PERK dimerization [ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003004
Super-classes obo:TXPO_0000713c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002997c
obo:RO_0000057op some obo:TXPO_0003005c

PERK dimer (canonical)[ER stress - cell cycle arrest]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003005
Super-classes obo:TXPO_0002880c
Restrictions obo:RO_0000056op some obo:TXPO_0003004c

CCND1 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003006
Super-classes obo:TXPO_1000088c
obo:TXPO_0000871c
Restrictions obo:RO_0000087op some obo:TXPO_0003562c
obo:TXPO_0002260op some obo:IMR_0100614c
obo:TXPO_0002260op some obo:IMR_0100615c

changing calcium ion concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003007
Super-classes obo:TXPO_0002438c
Sub-classes obo:TXPO_0003009c

changing calcium ion concentration in ER [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003008
Super-classes obo:TXPO_0001717c
obo:TXPO_0003009c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
obo:BFO_0000051op some obo:TXPO_0003014c
obo:TXPO_0001868op some obo:TXPO_0003010c
obo:TXPO_0000069op some obo:TXPO_0000513c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0003011c
obo:TXPO_0001868op some obo:TXPO_0003015c

changing calcium ion concentration in ERc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003009
Super-classes obo:TXPO_0003007c
Sub-classes obo:TXPO_0003008c

ritonavir [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003010
Super-classes obo:TXPO_0003012c
obo:TXPO_1000327c

lopinavir [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003011
Super-classes obo:CHEBI_31781c
obo:TXPO_0003012c

ER stress dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003012
Super-classes obo:TXPO_0000794c
Sub-classes obo:TXPO_0003020c
obo:TXPO_0001962c
obo:TXPO_0003027c
obo:TXPO_0003011c
obo:TXPO_0003015c
obo:TXPO_0001982c
obo:TXPO_0003029c
obo:TXPO_0003021c
obo:TXPO_0003024c
obo:TXPO_0001980c
obo:TXPO_0001981c
obo:TXPO_0003023c
obo:TXPO_0003028c
obo:TXPO_0003818c
obo:TXPO_0003010c
obo:TXPO_0003025c
obo:TXPO_0003819c

negative regulation of SERCA gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003013
Super-classes obo:GO_0010629c
Sub-classes obo:TXPO_0003014c

negative regulation of SERCA gene expression [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003014
Super-classes obo:TXPO_0001717c
obo:TXPO_0003013c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002101c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0003010c
obo:TXPO_0001868op some obo:TXPO_0003011c

thapsigargin [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003015
Super-classes obo:TXPO_0003012c
obo:CHEBI_9516c

negative regulation of endoplasmic reticulum-associated degradation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003016
Super-classes obo:TXPO_0000874c
obo:TXPO_0001717c
Restrictions obo:BFO_0000051op some obo:TXPO_0003017c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002479c

negative regulation of proteasomal protein catabolic process [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003017
Super-classes obo:TXPO_0001717c
obo:GO_1901799c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002479c
obo:TXPO_0000774op only obo:TXPO_0002528c

ABCC5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003018
Super-classes obo:TXPO_0002694c
Sub-classes obo:TXPO_0002792c

ABCC4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003019
Super-classes obo:TXPO_0002694c
Sub-classes obo:TXPO_0002787c
obo:TXPO_0002642c

MG-132 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003020
Super-classes obo:TXPO_0003012c
obo:CHEBI_75142c
Restrictions obo:RO_0000087op some obo:TXPO_0001147c

bortezomib [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003021
Super-classes obo:TXPO_0003012c
obo:CHEBI_52717c

PPARA - inactivated (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003022
Super-classes obo:TXPO_0001632c

nelfinavir [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003023
Super-classes obo:CHEBI_7496c
obo:TXPO_0003012c

atazanavir [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003024
Super-classes obo:TXPO_0003012c
obo:CHEBI_37924c

sorafenib [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003025
Super-classes obo:TXPO_0003012c
obo:CHEBI_50924c

intrinsic apotosis signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003026
Super-classes obo:TXPO_0003237c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0003737c
obo:TXPO_0002524op some obo:TXPO_0003111c

resveratrol [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003027
Super-classes obo:TXPO_0003012c
obo:CHEBI_27881c

STF-083010 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003028
Super-classes obo:TXPO_1000354c
obo:TXPO_0003012c

GSK2606414 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003029
Super-classes obo:TXPO_0003012c
obo:TXPO_1000172c
Restrictions obo:RO_0000087op some obo:TXPO_0000876c

receiving abnormal protein signal by ATF6 [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003030
Super-classes obo:TXPO_0002554c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000012op some obo:TXPO_0003031c
obo:TXPO_0000069op some obo:TXPO_0002909c
obo:TXPO_0001868op some obo:TXPO_0003032c
obo:TXPO_0000774op only obo:TXPO_0002528c

Dissociation of ATF6-alpha:BIP Complex [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003031
Super-classes obo:TXPO_0002903c
Restrictions obo:RO_0002234op some obo:TXPO_0003032c

ATF6 - stress sensor (canonical)[ER stress - apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003032
Super-classes obo:TXPO_0000879c
Restrictions obo:RO_0000056op some obo:TXPO_0003030c
obo:TXPO_0000774op only obo:TXPO_0002114c
obo:RO_0000087op some obo:TXPO_0000881c
obo:TXPO_0002260op some obo:IMR_0000825c

proapoptic gene regulation pathway by ATF6 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003033
Super-classes obo:TXPO_0002520c
Restrictions obo:BFO_0000051op some obo:TXPO_0002912c

HSP90B1 - chaperone (canonical)[ER stress -Refolding [persist]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003034
Super-classes obo:TXPO_0001960c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c

ATF4 gene expression by eIF2a [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003035
Super-classes obo:TXPO_0000707c
Restrictions obo:RO_0002234op some obo:TXPO_0002559c
obo:TXPO_0000069op some obo:TXPO_0003036c
obo:TXPO_0001868op some obo:TXPO_0000829c

inflammatory gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003036
Super-classes obo:TXPO_0000698c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002559c
obo:TXPO_0000069op some obo:TXPO_0003043c
obo:RO_0002234op some obo:TXPO_0003040c
obo:RO_0002234op some obo:TXPO_0003038c

IL-6 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003037
Super-classes obo:TXPO_0000871c
obo:IMR_0000010c
Sub-classes obo:TXPO_0003038c
obo:TXPO_0003067c

IL-6 - inflammatory cytokine (canonical)[ER stress - inflammation -ATF4 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003038
Super-classes obo:TXPO_0003037c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

NLRP1 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003039
Super-classes obo:TXPO_1000252c
obo:TXPO_0000871c
Sub-classes obo:TXPO_0003040c

NLRP1 - inflammatory substance (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003040
Super-classes obo:TXPO_0003039c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

inflammatory substance rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003041
Super-classes obo:CHEBI_52209c

type II diabetes coursec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003042
Super-classes obo:TXPO_0002033c
Restrictions obo:BFO_0000051op some obo:TXPO_0002443c
obo:BFO_0000051op some obo:TXPO_0003576c
obo:BFO_0000051op some obo:TXPO_0003581c

inflammatory cytokine gene expression via ATF4 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003043
Super-classes obo:TXPO_0003736c
obo:TXPO_0002266c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002766c
obo:BFO_0000051op some obo:TXPO_0003036c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0002524op some obo:TXPO_0002624c

ATF6-CREBPH-APR pathway [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003044
Super-classes obo:TXPO_0002548c
Restrictions obo:TXPO_0002524op some obo:TXPO_0003084c
obo:BFO_0000051op some obo:TXPO_0003081c
obo:BFO_0000051op some obo:TXPO_0003072c
obo:BFO_0000051op some obo:TXPO_0003045c
obo:TXPO_0002524op some obo:TXPO_0002126c

APR gene expression by ATF6 [ER stress - inflammation - ATF6-ARP]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003045
Super-classes obo:TXPO_0002521c
obo:TXPO_0003736c
Restrictions obo:RO_0002234op some obo:TXPO_0003048c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0003070c
obo:TXPO_0001868op some obo:TXPO_0003047c
obo:RO_0000057op some obo:TXPO_0003085c
obo:RO_0002234op some obo:TXPO_0003087c

ATF6 - transcriptional factor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003046
Super-classes obo:TXPO_0002468c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0002260op some obo:IMR_0000825c
Sub-classes obo:TXPO_0003047c

ATF6 -APR transcriptional factor (canonical)[ER stress - inflammation -APR]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003047
Super-classes obo:TXPO_0003046c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0002260op some obo:IMR_0000825c

APR gene (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003048
Super-classes obo:TXPO_1000008c
obo:TXPO_0000871c

GRP94 - chaperone (canonical)[proteinrefolding [persist]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003049
Super-classes obo:TXPO_0002410c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c

XBP1 - transcriptional regulator (canonical)[ER stress - Refolding -ATF6 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003050
Super-classes obo:TXPO_0001968c
Restrictions obo:RO_0000087op some obo:TXPO_0003051c
obo:TXPO_0000774op only obo:TXPO_0000413c

refolding promoting factor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003051
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002598op some obo:GO_0042026c

DNAJC3 (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003052
Super-classes obo:TXPO_0000871c
obo:TXPO_1000115c
Sub-classes obo:TXPO_0003053c

DNAJC3 -cochaperone (canonical)[ER stress -Refolding [persist]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003053
Super-classes obo:TXPO_0003052c
Restrictions obo:RO_0000087op some obo:TXPO_0002922c

ATF4 gene expression by eIF2a [ER stress - translation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003054
Super-classes obo:TXPO_0000707c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003057c

ATF4 - transcriptional regulator (canonical)[ER stress - translation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003055
Super-classes obo:TXPO_0001907c
Restrictions obo:TXPO_0001896op some obo:TXPO_0002966c
obo:RO_0000087op some obo:TXPO_0000330c

tranlation promotion gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003056
Super-classes obo:TXPO_0000698c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0002114c
obo:TXPO_0001868op some obo:TXPO_0003055c
Sub-classes obo:TXPO_0003057c

GADD34 gene expression by ATF4 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003057
Super-classes obo:TXPO_0003056c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002752c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0001868op some obo:TXPO_0003055c
obo:RO_0002234op some obo:TXPO_0002935c

PERK-ATF4-GADD34 signaling [ER stress - retranslation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003058
Super-classes obo:TXPO_0002513c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002483c
obo:BFO_0000051op some obo:TXPO_0003059c
obo:BFO_0000051op some obo:TXPO_0003054c
obo:BFO_0000051op some obo:TXPO_0003057c
obo:TXPO_0002524op some obo:TXPO_0000285c
obo:TXPO_0000774op only obo:TXPO_0002528c

PERK signaling to eIF2a [ER stress - translation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003059
Super-classes obo:TXPO_0002449c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003054c
obo:TXPO_0000774op only obo:TXPO_0002528c

peroxisome fatty acid beta oxidation gene expression(sustained) [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003060
Super-classes obo:TXPO_0000175c
obo:TXPO_0000174c
Restrictions obo:RO_0000057op some obo:TXPO_0001046c
obo:BFO_0000051op some obo:TXPO_0000110c
obo:RO_0000057op some obo:TXPO_0000846c
obo:RO_0000057op some obo:TXPO_0001069c
obo:RO_0000057op some obo:TXPO_0001057c
obo:TXPO_0000069op some obo:TXPO_0002451c
obo:TXPO_0000774op only obo:TXPO_0000028c

extrinsic apoptotic signaling pathway via death domain receptors [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003061
Super-classes obo:GO_0008625c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

TIMP1 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003062
Super-classes obo:TXPO_0003750c
obo:TXPO_1000373c

ATF6 processingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003063
Super-classes obo:GO_0016485c
Sub-classes obo:TXPO_0002467c
obo:TXPO_0003074c

IRE1 autophosphorylation [ER stress - RIDD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003064
Super-classes obo:TXPO_0002598c
obo:TXPO_0003736c
Restrictions obo:RO_0000057op some obo:TXPO_0002979c
obo:TXPO_0000774op only obo:TXPO_0002528c

inflammatory gene expression by XBP1 [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003065
Super-classes obo:TXPO_0002607c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002923c
obo:TXPO_0000774op only obo:TXPO_0000760c
obo:RO_0000057op some obo:TXPO_0003067c

XBP1 - transcriptional regulator (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003066
Super-classes obo:TXPO_0001968c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:TXPO_0001896op some obo:TXPO_0003065c

IL-6 - inflammatory cytokine (canonical)[ER stress - inflammation -XBP1 pathway]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003067
Super-classes obo:TXPO_0003037c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

ARP related gene expression via ATF6 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003068
Super-classes obo:TXPO_0003071c
obo:TXPO_0003736c
Restrictions obo:TXPO_0002524op some obo:TXPO_0002549c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0003045c

CRP (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003069
Super-classes obo:TXPO_0000871c
obo:TXPO_1000076c
Sub-classes obo:TXPO_0003070c

CRP - inflammatory substance (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003070
Super-classes obo:TXPO_0003069c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

ARP related gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003071
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0003068c

ATF6 signaling (primitive) [ER stress - inflammation - ATF6-ARP]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003072
Super-classes obo:TXPO_0002838c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003068c
obo:TXPO_0002524op some obo:TXPO_0003044c
obo:TXPO_0000774op only obo:TXPO_0003044c
obo:BFO_0000051op some obo:TXPO_0003073c

ATF6 activation [ER stress - inflammation - ARP]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003073
Super-classes obo:TXPO_0002924c
Restrictions obo:BFO_0000051op some obo:TXPO_0003074c

ATF6 processing [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003074
Super-classes obo:TXPO_0003063c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

cleavage of CREB by S1P [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003075
Super-classes obo:TXPO_0003736c
obo:TXPO_0003076c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003078c
obo:TXPO_0000774op only obo:TXPO_0002528c

cleavage of CREB by S1Pc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003076
Super-classes obo:TXPO_0000333c
Sub-classes obo:TXPO_0003075c

cleavage of CREB by S2Pc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003077
Super-classes obo:TXPO_0000333c
Sub-classes obo:TXPO_0003078c

cleavage of CREB by S2P [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003078
Super-classes obo:TXPO_0003077c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

CERB processing [ER stress - inflammation -ARP]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003079
Super-classes obo:TXPO_0003766c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000012op some obo:TXPO_0003078c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000012op some obo:TXPO_0003075c

CREB3L3 activation [ER stress - inflammation - ARP]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003080
Super-classes obo:TXPO_0000031c
obo:TXPO_0003736c
Restrictions obo:BFO_0000051op some obo:TXPO_0003079c
obo:TXPO_0000774op only obo:TXPO_0002528c

CREB3L3 signaling [ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003081
Super-classes obo:TXPO_0003736c
obo:TXPO_0000604c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002841c
obo:TXPO_0001868op some obo:TXPO_0002902c
obo:BFO_0000051op some obo:TXPO_0003080c
obo:TXPO_0000774op only obo:TXPO_0002528c

CRBPH (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003082
Super-classes obo:TXPO_1000074c
obo:TXPO_0000871c
Sub-classes obo:TXPO_0003083c
obo:TXPO_0003085c

CREBPH - signaling factor (canonical)[ER stress - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003083
Super-classes obo:TXPO_0003082c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000760c
obo:RO_0000056op some obo:TXPO_0003080c
obo:RO_0000087op some obo:TXPO_0001898c

ARP gene regulation pathway by ATF6 [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003084
Super-classes obo:TXPO_0002520c
Restrictions obo:BFO_0000051op some obo:TXPO_0003045c

CREBPH -APR transcriptional factor (canonical)[ER stress - inflammation -APR]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003085
Super-classes obo:TXPO_0003082c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0002260op some obo:IMR_0000825c

SAP (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003086
Super-classes obo:TXPO_0000871c
obo:TXPO_1000331c
Sub-classes obo:TXPO_0003087c

SAP - inflammatory factor (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003087
Super-classes obo:TXPO_0003086c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

IRE1 - autophosphorylation kinase (canonical)[ER stress -RIDD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003088
Super-classes obo:TXPO_0002601c
Restrictions obo:RO_0000056op some obo:TXPO_0002975c

IRE1 dimerization [ER stress - RIDD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003089
Super-classes obo:TXPO_0002596c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003064c
obo:RO_0000057op some obo:TXPO_0003090c
obo:TXPO_0000774op only obo:TXPO_0002528c

IRE1 dimer (canonical)[ER stress -RIDD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003090
Super-classes obo:TXPO_0002972c
Restrictions obo:RO_0000056op some obo:TXPO_0003089c

caspase 12 signaling (primitive) [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003091
Super-classes obo:TXPO_0003736c
obo:TXPO_0000444c
Restrictions obo:BFO_0000051op some obo:TXPO_0003093c
obo:TXPO_0000774op only obo:TXPO_0002528c

caspase 4 signaling (primitive) [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003092
Super-classes obo:TXPO_0000444c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000051op some obo:TXPO_0003094c

caspase-12 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003093
Super-classes obo:TXPO_0003736c
obo:TXPO_0003100c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

caspase-4 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003094
Super-classes obo:TXPO_0003736c
obo:TXPO_0003101c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0003096c

caspase activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003095
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:IMR_0000305c and ub744bL84862C17c)
Sub-classes obo:TXPO_0003100c
obo:TXPO_0003098c
obo:TXPO_0003099c
obo:TXPO_0003101c

caspase-9 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003096
Super-classes obo:TXPO_0003736c
obo:TXPO_0003099c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0003097c

caspase-3 activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003097
Super-classes obo:TXPO_0003098c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

caspase-3 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003098
Super-classes obo:TXPO_0003095c
Sub-classes obo:TXPO_0003097c

caspase-9 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003099
Super-classes obo:TXPO_0003095c
Sub-classes obo:TXPO_0003096c

caspase-12 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003100
Super-classes obo:TXPO_0003095c
Sub-classes obo:TXPO_0003093c

caspase-4 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003101
Super-classes obo:TXPO_0003095c
Sub-classes obo:TXPO_0003094c

caspase pathway [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003102
Super-classes obo:TXPO_0002482c
Restrictions obo:BFO_0000051op some obo:TXPO_0003109c
obo:BFO_0000051op some obo:TXPO_0000445c
obo:BFO_0000051op some obo:TXPO_0003104c
obo:BFO_0000051op some obo:TXPO_0003107c
obo:BFO_0000051op some obo:TXPO_0003091c
obo:BFO_0000051op some obo:TXPO_0003103c
obo:BFO_0000051op some obo:TXPO_0003092c

caspase 9 signaling (primitive) [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003103
Super-classes obo:TXPO_0003736c
obo:TXPO_0000444c
Restrictions obo:BFO_0000051op some obo:TXPO_0003096c
obo:TXPO_0000069op some obo:TXPO_0003104c
obo:TXPO_0000774op only obo:TXPO_0002528c

caspase 3 signaling (primitive) [ER stress - apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003104
Super-classes obo:TXPO_0000444c
obo:TXPO_0003736c
Restrictions obo:BFO_0000051op some obo:TXPO_0003097c
obo:RO_0000057op some obo:TXPO_0000502c
obo:TXPO_0000774op only obo:TXPO_0002528c

release of cytochrome c from mitochondria [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003105
Super-classes obo:GO_0001836c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003110c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0002528c

BAK activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003106
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:IMR_0000452c and ub744bL85028C17c)
Sub-classes obo:TXPO_0003123c
obo:TXPO_0003107c

BAK activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003107
Super-classes obo:TXPO_0003106c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:TXPO_0000069op some obo:TXPO_0003113c

BAX activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003108
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:IMR_0000453c and ub744bL85063C17c)
Sub-classes obo:TXPO_0003109c

BAX activation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003109
Super-classes obo:TXPO_0003108c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003113c
obo:TXPO_0000774op only obo:TXPO_0002528c

apoptosome assembly [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003110
Description

Apoptosome formation in cytosol
Super-classes obo:TXPO_0001717c
obo:GO_0097314c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003103c
obo:BFO_0000066op some obo:GO_0005737c

intrinsic apoptotic signaling pathway [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003111
Super-classes obo:GO_0097193c
Restrictions obo:BFO_0000051op some obo:TXPO_0002403c
obo:BFO_0000051op some obo:TXPO_0003235c
obo:BFO_0000051op some obo:TXPO_0003163c

allowingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003112
Super-classes obo:TXPO_0000600c

Bax/Bak complex formation [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003113
Description

Mitochondrial cytochrome c release can also be mediated by BAK and BAX which oligomerize and form a pore in the outer mitochondrial membrane, given the appropriate pro-apoptotic signals. BAX and BAK can also insert into the ER membrane to mediate Ca2+ release into the cytosol activating calpains.
Super-classes obo:TXPO_0003114c
obo:TXPO_0003736c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:BFO_0000066op some obo:GO_0005741c
obo:TXPO_0000069op some obo:TXPO_0003105c

Bax-Bak complex formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003114
Super-classes obo:GO_0006461c
Restrictions obo:BFO_0000066op some obo:GO_0005741c
Sub-classes obo:TXPO_0003113c

esgtradiol‐17β‐ glucuronide [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003115
Description

Changes in Bsep localization are involved in E217G-induced impairment of bile flow and bile salt transport.a Mrp2 is required for E217G to induce its harmful effect.
Super-classes obo:CHEBI_791c
obo:TXPO_0000749c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

positive regulation of gene expression via JNK signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003116
Super-classes obo:GO_0010628c
Restrictions obo:BFO_0000051op some obo:TXPO_0000769c
Sub-classes obo:TXPO_0002925c

binding to bile canaliculus membrane transporter by drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003117
Super-classes obo:GO_0005515c
Sub-classes obo:TXPO_0002652c

sulindac [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003118
Description

Sulindac is secreted into bile in unconjugated form by a canalicular bile acid transporter and is absorbed by cholangiocytes, inducing hypercholeresis. At high flux rates, sulindac competitively inhibits canalicular bile salt transport and may induce cholestasis in patients.
Super-classes obo:CHEBI_9352c
obo:TXPO_0000749c

FXR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003119
Super-classes obo:CHEBI_25367c
obo:TXPO_0001509c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c
obo:TXPO_0000819op some obo:OGG_3000009971c
Sub-classes obo:TXPO_0002643c
obo:TXPO_0003265c

PXR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003120
Super-classes obo:TXPO_0001509c
obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c
obo:TXPO_0000819op some obo:OGG_3000008856c
Sub-classes obo:TXPO_0002726c

GR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003121
Super-classes obo:TXPO_0001509c
obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0003224c
obo:TXPO_0000819op some obo:OGG_3000002908c
Sub-classes obo:TXPO_0002725c

back-flowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003122
Super-classes obo:TXPO_0000022c
Sub-classes obo:TXPO_0000590c

BAK activation [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003123
Super-classes obo:TXPO_0003106c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c

import substances into hepatocyte vascular side (sinusoidal side) membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003124
Super-classes obo:GO_0006810c
Sub-classes obo:TXPO_0001759c

LRH1 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003125
Description

Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the rate-limiting step in bile acid biosynthesis. FXR induces expression of SHP-1, a member of the nuclear receptor family that lacks a DNA-binding domain. SHP-1 represses expression of CYP7A1 by inhibiting the activity of liver receptor homolog 1 (LRH-1).
Super-classes obo:TXPO_1000227c
obo:TXPO_0000276c

negative regularuion of bile acid and bile salt transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003126
Super-classes obo:TXPO_0002682c
Sub-classes obo:TXPO_0002646c

SLCO1A2 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003127
Description

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Super-classes obo:TXPO_0000272c

phosphorus atomc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003128
Super-classes obo:CHEBI_33250c

contractionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003129
Super-classes obo:TXPO_0000765c
Sub-classes obo:TXPO_0002695c

bile accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003130
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:UBERON_0001970c
Sub-classes obo:TXPO_0000263c

erythromycin estolate [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003131
Description

Erythromycin estolate, troglitazone, and bosentan resulted in a decrease in , bile excretion and in vitro biliary clearance of euterium-labeled sodium taurocholate
Super-classes obo:CHEBI_4846c
obo:TXPO_0000749c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

cyclosporineA [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003132
Description

Cyclosporine, an MDR1 substrate, can cause cholestatic liver injury through a number of different mechanisms:

i) Competitive inhibition of ATP dependent transporters, ii) Iinhibition of intrahepatic vesicle transport and targeting of ATP dependent transporters to the canalicular membrane and iii) Impairment of bile secretion partly by increasing canalicular membrane fluidity without affecting the expression of canalicular transporter.
Super-classes obo:CHEBI_4031c
obo:TXPO_0000749c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

vesicle-mediated transport [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003133
Super-classes obo:TXPO_0000034c
obo:GO_0016192c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

increasing glutathione [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003134
Super-classes obo:TXPO_0003151c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

cholesterol biosynthetic process [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003135
Super-classes obo:GO_0006695c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

increasing bile level [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003136
Super-classes obo:TXPO_0000034c
obo:TXPO_0002714c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:BFO_0000051op some obo:TXPO_0003137c

increasing materials for bile formation [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003137
Super-classes obo:TXPO_0003144c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:BFO_0000051op some obo:TXPO_0003135c

regulation of transporter gene expression by cytokinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003138
Description

IL-1beta, TNF-alpha or IL-6 alters human hepatic transporters expression. Bile salt transporters as well as sinusoidal solute carrier transporters are usually repressed, whereas ATP-binding cassette drug efflux pumps remain unchanged or are either downregulated or upregulated. They maight alter drug pharmacokinetics, impairment of bile salt secretion and cholestasis caused by inflammation in humans.
Super-classes obo:TXPO_0003139c
Sub-classes obo:TXPO_0003154c

regulation of transporter gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003139
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0003138c

decreasing bile acid production levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003140
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0002658c

bile thrombus formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003141
Super-classes obo:TXPO_0000134c
Sub-classes obo:TXPO_0003142c

bile thrombus formation in bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003142
Super-classes obo:TXPO_0003141c
Sub-classes obo:TXPO_0002660c

farnesoid X receptor activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003143
Super-classes obo:TXPO_0000158c
Restrictions obo:RO_0002234op some (obo:TXPO_0003119c and ub744bL85449C17c)
Sub-classes obo:TXPO_0002644c

increasing materials for bile formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003144
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003137c

Farnesoid X Receptor Pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003145
Super-classes obo:TXPO_0001902c
Restrictions obo:BFO_0000051op some obo:TXPO_0003143c
obo:BFO_0000051op some obo:TXPO_0003146c
Sub-classes obo:TXPO_0003149c

gene expression by farnesoid X receptorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003146
Super-classes obo:TXPO_0000375c
Sub-classes obo:TXPO_0003147c

gene expression by farnesoid X receptor [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003147
Super-classes obo:TXPO_0003146c
obo:TXPO_0000034c
Restrictions obo:TXPO_0001868op some obo:TXPO_0002643c
obo:RO_0002234op some obo:TXPO_0000547c
obo:RO_0002234op some obo:TXPO_0000724c
obo:RO_0002234op some obo:TXPO_0000299c
obo:RO_0000057op some obo:TXPO_0003148c
obo:RO_0000057op some obo:TXPO_0002723c

FGF19 (canonical)[Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003148
Super-classes obo:TXPO_1000143c
obo:TXPO_0000276c

Farnesoid X Receptor Pathway [cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003149
Description

Farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport.
Super-classes obo:TXPO_0003145c
Restrictions obo:BFO_0000051op some obo:TXPO_0003147c
obo:BFO_0000051op some obo:TXPO_0002644c

acumulation of bile pigment in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003150
Super-classes obo:TXPO_0000083c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0002679c

increasing glutathionec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003151
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003134c

excretion of drug metabolite from hepatocyte to bile tubec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003152
Super-classes obo:TXPO_0002077c
Sub-classes obo:TXPO_0000956c
obo:TXPO_0002638c

drug export from the hepatocyte to to bile tubec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003153
Super-classes obo:TXPO_0002077c
Sub-classes obo:TXPO_0002637c

regulation of transporter gene expression by cytokine [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003154
Super-classes obo:TXPO_0003138c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

negative regulation of contractile movement of bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003155
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0002695c
Sub-classes obo:TXPO_0002667c

constituent of toxic coursec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003156
Super-classes obo:TXPO_0002178c

Bip-unfolded protein complex [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003157
Super-classes obo:TXPO_0002115c
Restrictions obo:RO_0002180op some obo:TXPO_0000132c
obo:RO_0002180op some obo:TXPO_0002385c
Sub-classes obo:TXPO_0002907c
obo:TXPO_0002905c
obo:TXPO_0002906c

cateninc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003158
Super-classes obo:CHEBI_25367c
Sub-classes obo:IMR_0000177c
obo:IMR_0000176c

regulator of cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003159
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0008283c
Sub-classes obo:TXPO_0003534c
obo:TXPO_0002271c
obo:TXPO_0004045c

hypofunction of glycogen degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003160
Super-classes obo:TXPO_0000940c
Restrictions obo:RO_0002233op some obo:CHEBI_28087c
obo:TXPO_0000716op some obo:GO_0005980c

calcium channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003161
Super-classes obo:TXPO_0002803c

JUN (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003162
Super-classes obo:TXPO_0002045c
obo:IMR_0000416c

Activation and oligomerization of BAK protein [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003163
Description

Mitochondrial cytochrome c release can also be mediated by BAK and BAX which oligomerize and form a pore in the outer mitochondrial membrane, given the appropriate pro-apoptotic signals. BAX and BAK can also insert into the ER membrane to mediate Ca2+ release into the cytosol activating calpains.
Super-classes obo:TXPO_0001727c
obo:HINO_0016227c
Restrictions obo:RO_0000057op some obo:TXPO_0003198c
obo:RO_0000057op some obo:TXPO_0003199c
obo:TXPO_0000774op only obo:TXPO_0000323c

GLUTATHIONE (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003164
Super-classes obo:CHEBI_16856c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:CHEBI_22586c

GLUTATHIONE peroxidase (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003165
Super-classes obo:TXPO_1000177c
obo:TXPO_0002045c
Restrictions obo:TXPO_0002260op some obo:IMR_0010278c

CASPASE 3 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003166
Super-classes obo:TXPO_0002045c
obo:TXPO_0001145c

NFKB (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003167
Super-classes obo:TXPO_1000258c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0002260op some obo:IMR_0000382c

inflammatory response [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003168
Super-classes obo:TXPO_0000889c
obo:TXPO_0000192c
Restrictions obo:BFO_0000051op some obo:TXPO_0003208c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0000501c

hepatic fibrosis [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003169
Super-classes obo:TXPO_0000889c
obo:TXPO_0000816c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0002373c

CYP2E1 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003170
Super-classes obo:TXPO_1000081c
obo:TXPO_0002045c

CYP3A4 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003171
Super-classes obo:TXPO_1000082c
obo:TXPO_0002045c

IL-6 - inflammatory cytokine (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003172
Super-classes obo:TXPO_0002045c
obo:IMR_0000010c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

reactive oxygen species biosynthetic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003173
Super-classes obo:GO_1903409c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003178c

increasing demand for response to oxidative stress [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003174
Super-classes obo:TXPO_0000102c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003177c
obo:TXPO_0000774op only obo:TXPO_0000501c

increasing anti-oxidation demand [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003175
Super-classes obo:TXPO_0000889c
obo:TXPO_0003176c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003177c
obo:TXPO_0000774op only obo:TXPO_0000501c

increasing anti-oxidation demandc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003176
Super-classes obo:TXPO_0000633c
Sub-classes obo:TXPO_0003175c

oxidation-antioxidtion inbalance [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003177
Super-classes obo:TXPO_0000889c
obo:TXPO_0002748c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001207c
obo:TXPO_0000774op only obo:TXPO_0000501c

ROS accumulation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003178
Super-classes obo:TXPO_0000889c
obo:TXPO_0003179c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001199c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003174c

ROS accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003179
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_26523c
Sub-classes obo:TXPO_0003178c

hyperfunction of peroxisomal fatty acid beta-oxidation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003180
Super-classes obo:TXPO_0000889c
obo:TXPO_0000177c
Restrictions obo:BFO_0000066op some obo:GO_0005777c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003173c

ATP biosynthetic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003181
Super-classes obo:GO_0006754c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003173c

iron accumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003182
Super-classes obo:TXPO_0000247c
Restrictions obo:RO_0002233op some obo:CHEBI_18248c
Sub-classes obo:TXPO_0004661c
obo:TXPO_0004397c
obo:TXPO_0003183c

iron accumulation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003183
Super-classes obo:TXPO_0000889c
obo:TXPO_0003182c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003173c

kupffer cell activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003184
Super-classes obo:GO_0042116c
Sub-classes obo:TXPO_0003743c
obo:TXPO_0003185c

kupffer cell activation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003185
Super-classes obo:TXPO_0000889c
obo:TXPO_0003184c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003173c

accumulation of ethanol in intestine [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003186
Super-classes obo:TXPO_0003187c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001180c

accumulation of ethanol in intestinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003187
Super-classes obo:TXPO_0000169c
Restrictions obo:RO_0002233op some obo:CHEBI_16236c
obo:BFO_0000066op only obo:UBERON_0000160c
Sub-classes obo:TXPO_0003186c

LPS translocation from gut to liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003188
Super-classes obo:GO_0006810c
Restrictions obo:RO_0002339op some obo:UBERON_0002107c
obo:RO_0002338op some obo:UBERON_0000160c
Sub-classes obo:TXPO_0003189c

LPS translocation from gut to liver [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003189
Super-classes obo:TXPO_0003188c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0003185c

BAX (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003190
Super-classes obo:TXPO_0002045c
obo:IMR_0000453c
Restrictions obo:RO_0000087op some obo:TXPO_0000327c

IL-1B (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003191
Super-classes obo:TXPO_1000200c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

IL-10 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003192
Super-classes obo:IMR_0000589c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

IL-4 (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003193
Super-classes obo:IMR_0000585c
obo:TXPO_0002045c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

TNF-A (canonical)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003194
Super-classes obo:TXPO_1000374c
obo:TXPO_0002045c

cell death dependent dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003195
Super-classes obo:TXPO_0000838c
Sub-classes obo:TXPO_0003828c
obo:TXPO_0003204c
obo:TXPO_0003202c
obo:TXPO_0003196c
obo:TXPO_0003205c
obo:TXPO_0003198c
obo:TXPO_0003201c
obo:TXPO_0003200c
obo:TXPO_0000843c
obo:TXPO_0000653c
obo:TXPO_0003826c
obo:TXPO_0003203c
obo:TXPO_0003236c
obo:TXPO_0003197c
obo:TXPO_0003206c
obo:TXPO_0003199c
obo:TXPO_0000845c

APAF1 (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003196
Super-classes obo:TXPO_0003195c
obo:TXPO_1000005c

BAD (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003197
Super-classes obo:IMR_0100288c
obo:TXPO_0003195c

BAK1 (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003198
Super-classes obo:TXPO_0003195c
obo:TXPO_1000040c

BID (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003199
Super-classes obo:IMR_0100289c
obo:TXPO_0003195c

FAS (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003200
Super-classes obo:TXPO_0003195c
obo:TXPO_1000139c

TNF (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003201
Super-classes obo:TXPO_0003195c
obo:TXPO_1000374c

TP53 (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003202
Super-classes obo:TXPO_0003195c
obo:IMR_0100659c

TRADD (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003203
Super-classes obo:TXPO_0003195c
obo:IMR_0100464c

CASP8 (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003204
Super-classes obo:TXPO_0003195c
obo:TXPO_1000058c

CASPASE-3 (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003205
Super-classes obo:TXPO_0003195c
obo:TXPO_0001145c

TRAF3 (canonical)[apotosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003206
Super-classes obo:IMR_0100424c
obo:TXPO_0003195c

negative regulation of inflammatory response [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003207
Super-classes obo:TXPO_0001729c
obo:TXPO_0002243c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000136c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:BFO_0000066op some obo:UBERON_0002107c

inflammatory cytokine gene expression [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003208
Super-classes obo:TXPO_0002266c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c

tumorigenesis [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003209
Super-classes obo:NCIT_C18121c
obo:TXPO_0000889c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:RO_0000057op some obo:TXPO_0000847c
obo:TXPO_0000774op only obo:TXPO_0000501c

lipid storage in liver [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003210
Super-classes obo:TXPO_0001717c
obo:TXPO_0001276c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c

hepatic fibrosis [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003211
Super-classes obo:TXPO_0000034c
obo:TXPO_0000816c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:TXPO_0000069op some obo:TXPO_0003212c
obo:BFO_0000066op some obo:UBERON_0002107c

liver dysfunction [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003212
Super-classes obo:TXPO_0000203c
obo:TXPO_0000034c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001277c
obo:BFO_0000066op some obo:UBERON_0002107c

phospholipidosis dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003213
Super-classes obo:TXPO_0001133c
Sub-classes obo:TXPO_0001801c
obo:TXPO_0003272c
obo:TXPO_0002288c
obo:TXPO_0003477c
obo:TXPO_0003273c
obo:TXPO_0002408c
obo:TXPO_0003346c
obo:TXPO_0004090c
obo:TXPO_0001803c
obo:TXPO_0001806c
obo:TXPO_0004019c
obo:TXPO_0002294c
obo:TXPO_0000775c
obo:TXPO_0001798c
obo:TXPO_0003347c
obo:TXPO_0004072c
obo:TXPO_0001800c
obo:TXPO_0004026c
obo:TXPO_0001799c
obo:TXPO_0003892c
obo:TXPO_0001802c
obo:TXPO_0001464c
obo:TXPO_0003571c
obo:TXPO_0000702c
obo:TXPO_0004061c
obo:TXPO_0003556c
obo:TXPO_0001805c
obo:TXPO_0001804c

Osgin1 - apotosis inducing factor (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003214
Super-classes obo:TXPO_0000641c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c

Osgin1 - cancer repressor (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003215
Super-classes obo:TXPO_0000641c
Restrictions obo:RO_0000087op some obo:TXPO_0000329c
obo:RO_0000087op some obo:TXPO_0000668c

Osgin1 - oxidative stress response protein (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003216
Super-classes obo:TXPO_0000641c
Restrictions obo:RO_0000087op some obo:TXPO_0000668c

TP53 - apotosis inducing factor (canonical)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003217
Super-classes obo:TXPO_0000843c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c

negative regulation of cytokine gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003218
Super-classes obo:GO_0010629c
Sub-classes obo:TXPO_0000190c

pexophagy [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003219
Super-classes obo:GO_0000425c
obo:TXPO_0001729c
Restrictions obo:RO_0000057op some obo:TXPO_0003253c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:TXPO_0000069op some obo:TXPO_0003207c
obo:RO_0002233op some obo:GO_0005777c
obo:RO_0000057op some obo:TXPO_0003255c

conpetitive inhibitor of phospholipasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003220
Super-classes obo:TXPO_0000559c

AMPK (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003221
Description

AMPK is a highly evolutionarily conserved serine/threonine kinase, and orthologs of the AMPK subunits are found in all eukaryotic species. At the molecular level, AMPK is a heterotrimer complex comprising a catalytic alpha subunit, with a conventional serine/threonine protein kinase domain, and two regulatory subunits, beta and gamma. In mammals, each subunit is encoded by multiple genes (alpha1, alpha2, beta1, beta2, gamma1, gamma2, gamma3), which results in 12 possible combinations of AMPK complex.
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005562c
Sub-classes obo:TXPO_0001652c
obo:TXPO_0005066c
obo:IMR_0002778c
obo:TXPO_0000944c
obo:IMR_0002777c
obo:TXPO_0000873c

molecular subpathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003222
Super-classes obo:NCIT_C54214c
Sub-classes obo:HINO_0016241c
obo:HINO_0016227c
obo:HINO_0016226c

PI3K (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003223
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005290c
Sub-classes obo:IMR_0000267c
obo:TXPO_0001800c
obo:IMR_0000265c

nuclear receptorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003224
Description

hasrelated molecular function GO:0004879
Super-classes obo:TXPO_0002463c
Restrictions obo:RO_0002596op some obo:GO_0006351c

imipramine - apotosis inducing factor [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003225
Super-classes obo:TXPO_0001849c
obo:CHEBI_47499c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c

amiodarone - apotosis inducing factor [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003226
Super-classes obo:TXPO_0001849c
obo:CHEBI_2663c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0000774op only obo:TXPO_0000928c

amiodarone - phospholipase competition inhibitor [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003227
Super-classes obo:CHEBI_2663c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0001426c
obo:RO_0000087op some obo:TXPO_0003220c

imipramine - phospholipase competition inhibitor [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003228
Super-classes obo:CHEBI_47499c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0003220c
obo:RO_0000087op some obo:TXPO_0001426c

AKT - cell proliferation promoting factor (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003229
Super-classes obo:TXPO_0001799c
Restrictions obo:RO_0000087op some obo:TXPO_0002271c
obo:TXPO_0000774op only obo:TXPO_0001490c
obo:TXPO_0002260op some obo:IMR_0000250c

process regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003230
Super-classes obo:TXPO_0003710c
Sub-classes obo:TXPO_0002629c
obo:TXPO_0003880c
obo:TXPO_0002406c
obo:TXPO_0000189c
obo:TXPO_0003726c
obo:TXPO_0003720c
obo:TXPO_0004115c
obo:TXPO_0002353c
obo:TXPO_0003564c
obo:TXPO_0002184c
obo:CHEBI_38632c
obo:TXPO_0003351c
obo:TXPO_0002247c
obo:TXPO_0001082c
obo:TXPO_0002261c
obo:TXPO_0003724c
obo:TXPO_0003725c
obo:TXPO_0003051c
obo:TXPO_0000423c
obo:TXPO_0001969c
obo:TXPO_0000327c
obo:TXPO_0000330c
obo:TXPO_0003159c
obo:TXPO_0004023c
obo:TXPO_0000036c
obo:TXPO_0000623c
obo:TXPO_0002284c
obo:TXPO_0003888c
obo:TXPO_0002557c
obo:TXPO_0002250c
obo:TXPO_0003650c
obo:TXPO_0002286c

regulation of cell cycle [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003231
Super-classes obo:GO_0051726c
obo:TXPO_0001729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002173c
obo:TXPO_0000069op some obo:TXPO_0003232c
obo:TXPO_0000774op only obo:TXPO_0000028c

tumor cell proliferation [Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003232
Super-classes obo:TXPO_0000339c
obo:TXPO_0001729c
()
Restrictions obo:RO_0000057op some obo:TXPO_0003245c
obo:TXPO_0000774op only obo:TXPO_0000028c
obo:BFO_0000066op some obo:NCBITaxon_9989c

increasing liver weight [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003233
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0003271c
obo:BFO_0000051op some obo:TXPO_0003286c
obo:BFO_0000051op some obo:TXPO_0003297c
obo:BFO_0000051op some obo:TXPO_0003304c
obo:BFO_0000051op some obo:TXPO_0003316c
obo:BFO_0000051op some obo:TXPO_0000217c
obo:BFO_0000051op some obo:TXPO_0003299c
obo:TXPO_0000004op some obo:TXPO_0003271c
obo:BFO_0000051op some obo:TXPO_0003309c

tumorigenesis via eosinophilic granular degeneration [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003234
Super-classes obo:TXPO_0000028c
Restrictions obo:BFO_0000051op some obo:TXPO_0000179c
obo:BFO_0000051op some obo:TXPO_0000479c
obo:BFO_0000051op some obo:TXPO_0000196c
obo:BFO_0000051op some obo:TXPO_0000149c
obo:BFO_0000051op some obo:TXPO_0000136c
obo:BFO_0000051op some obo:TXPO_0003231c
obo:BFO_0000051op some obo:TXPO_0000184c
obo:BFO_0000051op some obo:TXPO_0002448c
obo:BFO_0000051op some obo:TXPO_0000103c
obo:BFO_0000051op some obo:TXPO_0003207c
obo:BFO_0000051op some obo:TXPO_0000746c
obo:BFO_0000051op some obo:TXPO_0000187c
obo:BFO_0000051op some obo:TXPO_0003060c
obo:BFO_0000051op some obo:TXPO_0000153c
obo:BFO_0000051op some obo:TXPO_0002029c
obo:BFO_0000051op some obo:TXPO_0000128c
obo:BFO_0000051op some obo:TXPO_0000198c
obo:BFO_0000051op some obo:TXPO_0002173c
obo:BFO_0000051op some obo:TXPO_0000146c
obo:BFO_0000051op some obo:TXPO_0000125c
obo:BFO_0000051op some obo:TXPO_0002451c
obo:BFO_0000051op some obo:TXPO_0002100c
obo:BFO_0000051op some obo:TXPO_0003219c
obo:BFO_0000051op some obo:TXPO_0000116c
obo:BFO_0000051op some obo:TXPO_0001025c
obo:BFO_0000051op some obo:TXPO_0002391c
obo:BFO_0000051op some obo:TXPO_0003232c
obo:BFO_0000051op some obo:TXPO_0000190c
obo:BFO_0000051op some obo:TXPO_0000182c
obo:BFO_0000051op some obo:TXPO_0000151c
obo:BFO_0000051op some obo:TXPO_0000109c
obo:BFO_0000051op some obo:TXPO_0000110c
obo:BFO_0000051op some obo:TXPO_0000127c
obo:TXPO_0000004op some obo:TXPO_0000136c

Activation, translocation and oligomerization of BAX [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003235
Description

As a result of binding to Bid, Bax oligomerizes and integrates in the outer mitochondrial membrane that triggers cytochrome c release. Bax mitochondrial membrane insertion triggered by Bid may represent a key step in pathways leading to apoptosis (Eskes et al., 2000)
Super-classes obo:TXPO_0001727c
obo:HINO_0016226c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000323c
obo:RO_0000057op some obo:TXPO_0003236c

BAX (canonical)[cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003236
Super-classes obo:IMR_0000453c
obo:TXPO_0003195c
Restrictions obo:RO_0000087op some obo:TXPO_0000327c

intrinsic apoptosis signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003237
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0097193c
obo:RO_0000057op some obo:TXPO_0000653c
obo:TXPO_0000774op only obo:TXPO_0000323c
obo:TXPO_0000069op some obo:TXPO_0000514c
Sub-classes obo:TXPO_0003026c

Cdk1 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003238
Super-classes obo:TXPO_0003239c
obo:TXPO_0000648c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Cdk1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003239
Super-classes obo:TXPO_0003241c
Sub-classes obo:TXPO_0003238c

Cdk4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003240
Super-classes obo:TXPO_0003241c
Sub-classes obo:TXPO_0003242c

CDK (family)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003241
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001966c
Sub-classes obo:TXPO_0003240c
obo:TXPO_0003239c
obo:IMR_0100599c
obo:IMR_0100597c
obo:IMR_0100598c
obo:IMR_0100602c
obo:TXPO_0002398c
obo:IMR_0100604c
obo:IMR_0100603c
obo:IMR_0100605c
obo:IMR_0100601c

Cdk4(mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003242
Super-classes obo:TXPO_0003240c
obo:TXPO_0000648c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Ppara (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003243
Super-classes obo:TXPO_0000648c
obo:TXPO_0000159c
Sub-classes obo:TXPO_0003244c

Ppara - cell cycle regulator (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003244
Super-classes obo:TXPO_0003243c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0002247c

Myc (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003245
Super-classes obo:TXPO_0000648c
obo:IMR_0000383c
Restrictions obo:TXPO_0002260op some obo:IMR_0000383c
obo:TXPO_0000756op some obo:TXPO_0000489c

ACAA1A (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003246
Super-classes obo:TXPO_0001034c
obo:TXPO_1000017c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

Acaa1a (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003247
Super-classes obo:TXPO_1000017c
obo:TXPO_0000648c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Acox1 (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003248
Super-classes obo:TXPO_1000027c
obo:TXPO_0000648c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:TXPO_0000819op some obo:OGG_3000000051c

ACOX1 (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003249
Super-classes obo:TXPO_1000027c
obo:TXPO_0001034c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0000819op some obo:OGG_3000000051c

Ehhadh (mouse)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003250
Super-classes obo:TXPO_0000648c
obo:TXPO_1000131c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

drug transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003251
Super-classes obo:TXPO_0003638c

ATM (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003252
Super-classes obo:TXPO_0001146c
Sub-classes obo:TXPO_0003253c

ATM (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003253
Super-classes obo:TXPO_0001034c
obo:TXPO_0003252c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

PEX5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003254
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008800c
Sub-classes obo:TXPO_0003255c

PEX5 (human)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003255
Super-classes obo:TXPO_0001034c
obo:TXPO_0003254c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

farnesoid X receptor inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003256
Super-classes obo:TXPO_0001589c
Restrictions obo:RO_0002234op some (obo:TXPO_0003119c and ub744bL86922C17c)
Sub-classes obo:TXPO_0003264c

hyperfunction of drug transporter gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003257
Super-classes obo:TXPO_0002345c
Sub-classes obo:TXPO_0003258c

hyperfunction of drug transporter gene expression [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003258
Super-classes obo:TXPO_0003257c
obo:TXPO_0001728c
Restrictions obo:RO_0002234op some obo:TXPO_0003263c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0002234op some obo:TXPO_0001032c
obo:TXPO_0000069op some obo:TXPO_0003260c

hyperfunction of bile acid transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003259
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:GO_0015721c
Sub-classes obo:TXPO_0003260c

hyperfunction of bile acid transport [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003260
Super-classes obo:TXPO_0001728c
obo:TXPO_0003259c
Restrictions obo:RO_0000057op some obo:TXPO_0001032c
obo:RO_0000057op some obo:TXPO_0003263c
obo:TXPO_0000774op only obo:TXPO_0001432c

Sgpl1 - lipid metabolism regulator (rat)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003261
Super-classes obo:TXPO_0001151c
Restrictions obo:RO_0000087op some obo:TXPO_0002358c
obo:TXPO_0000756op some obo:TXPO_0000489c

Sgpl1 - tumor cell proliferationregulating factor (mouse) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003262
Super-classes obo:TXPO_0003529c
Restrictions obo:RO_0000087op some obo:TXPO_0003534c
obo:TXPO_0000756op some obo:TXPO_0000489c

Mrp2 (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003263
Super-classes obo:TXPO_0001071c
obo:TXPO_0002496c

Farnesoid X Receptor inactivation [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003264
Super-classes obo:TXPO_0003256c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:TXPO_0000069op some obo:TXPO_0001121c
obo:TXPO_0000069op some obo:TXPO_0001117c
obo:RO_0002233op some obo:TXPO_0003265c
obo:RO_0002234op some obo:TXPO_0003266c

FXR (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003265
Description

https://omim.org/entry/603826
Super-classes obo:TXPO_0003516c
obo:TXPO_0003119c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:TXPO_0003266c

FXR -inactivated state (canonical)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003266
Description

https://omim.org/entry/603826
Super-classes obo:TXPO_0003265c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:RO_0000086op some obo:PATO_0002355c

malfunction of biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003267
Super-classes obo:TXPO_0000434c
Restrictions obo:TXPO_0001518op some obo:GO_0009058c
Sub-classes obo:TXPO_0003268c
obo:TXPO_0004100c
obo:TXPO_0003275c

malfunction of lipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003268
Super-classes obo:TXPO_0003267c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
Sub-classes obo:TXPO_0002197c

hypofunction of phospholipid transport from ER to mitochondrial membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003269
Super-classes obo:TXPO_0001911c
Sub-classes obo:TXPO_0003270c

hypofunction of phospholipid transport from ER to mitochondrial membrane [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003270
Super-classes obo:TXPO_0003269c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001810c
obo:TXPO_0000774op only obo:TXPO_0002528c

increasing liver weight [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003271
Super-classes obo:TXPO_0000054c
obo:TXPO_0003279c
Restrictions obo:BFO_0000051op some obo:TXPO_0003286c
obo:BFO_0000051op some obo:TXPO_0000217c
obo:TXPO_0000774op only obo:TXPO_0003233c
obo:BFO_0000051op some obo:TXPO_0003297c

CASPASE-2 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003272
Super-classes obo:TXPO_0003213c
obo:IMR_0100303c
Restrictions obo:TXPO_0002260op some obo:IMR_0000305c
obo:TXPO_0000819op some obo:OGG_3000000835c

CASPASE-3 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003273
Super-classes obo:TXPO_0003213c
obo:TXPO_0001145c
Restrictions obo:TXPO_0002260op some obo:IMR_0000305c
obo:TXPO_0000819op some obo:OGG_3000000836c

Fgf21 (mouse)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003274
Super-classes obo:TXPO_1000145c
obo:TXPO_0000812c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026291c
obo:TXPO_0002260op some obo:IMR_0100571c
obo:TXPO_0000756op some ncicp:C15958c

malfunction of phospholipid biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003275
Super-classes obo:TXPO_0003267c
Restrictions obo:BFO_0000066op some obo:GO_0005783c
Sub-classes obo:TXPO_0003276c

malfunction of phospholipid biosynthesis [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003276
Super-classes obo:TXPO_0003275c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003270c
obo:TXPO_0000069op some obo:TXPO_0002199c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000774op only obo:TXPO_0002528c

Ero1lb (mouse)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003277
Super-classes obo:TXPO_0000812c
obo:TXPO_1000126c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c

phospholipidosis dependent molecule (mouse)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003278
Super-classes obo:TXPO_0001133c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10090c
Sub-classes obo:TXPO_0004108c
obo:TXPO_0003529c
obo:TXPO_0002244c
obo:TXPO_0004018c
obo:TXPO_0003996c
obo:TXPO_0004092c
obo:TXPO_0003895c
obo:TXPO_0003897c
obo:TXPO_0003916c
obo:TXPO_0000188c

increasing liver weight dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003279
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c
obo:BFO_0000066op some obo:UBERON_0002107c
Sub-classes obo:TXPO_0000739c
obo:TXPO_0003298c
obo:TXPO_0003302c
obo:TXPO_0003300c
obo:TXPO_0003305c
obo:TXPO_0003271c
obo:TXPO_0003297c
obo:TXPO_0003309c
obo:TXPO_0001266c
obo:TXPO_0001422c
obo:TXPO_0003286c
obo:TXPO_0003319c
obo:TXPO_0003304c
obo:TXPO_0003296c
obo:TXPO_0003310c
obo:TXPO_0003316c
obo:TXPO_0000217c
obo:TXPO_0003314c
obo:TXPO_0003299c

ANG (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003280
Super-classes obo:TXPO_0001517c
obo:TXPO_0001135c
Restrictions obo:RO_0000087op some obo:TXPO_0002261c
obo:TXPO_0000756op some ncicp:C15958c

CXCL10 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003281
Super-classes obo:TXPO_1000419c
Restrictions obo:RO_0000056op some obo:TXPO_0000192c
obo:TXPO_0000756op some ncicp:C15958c
Sub-classes obo:TXPO_0000754c
obo:TXPO_0004665c

hypofunction of phospholipid degradation [Phospholipidosis (moderate)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003282
Super-classes obo:TXPO_0000925c
Restrictions obo:RO_0000057op some obo:TXPO_0000775c
obo:RO_0000057op some obo:TXPO_0001804c
obo:TXPO_0000716op some obo:TXPO_0001406c
obo:TXPO_0000069op some obo:TXPO_0003372c
obo:TXPO_0000774op only obo:TXPO_0003369c

NPC1 (canonical)[Niemann Pick Type C]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003283
Super-classes obo:TXPO_0003516c
obo:TXPO_0003284c
Restrictions obo:RO_0000087op some obo:TXPO_0001451c

NPC1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003284
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003283c

NPC2 (canonical)[Niemann-Pick Type C]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003285
Super-classes obo:TXPO_0003516c
obo:TXPO_0003287c
Restrictions obo:RO_0000087op some obo:TXPO_0001451c

cell proliferation [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003286
Super-classes obo:GO_0008283c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003271c
obo:BFO_0000051op some obo:TXPO_0003319c
obo:TXPO_0000774op only obo:TXPO_0003233c
obo:BFO_0000051op some obo:TXPO_0003298c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:BFO_0000051op some obo:TXPO_0003296c

NPC2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003287
Super-classes obo:TXPO_0003516c
obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001451c
Sub-classes obo:TXPO_0003285c

hypofunction of glutathione conjugation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003288
Super-classes obo:TXPO_0001775c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001191c

insulin deficiency [diabetes course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003289
Super-classes obo:TXPO_0000072c
obo:TXPO_0003342c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003290c
obo:TXPO_0000774op only obo:TXPO_0002033c
Sub-classes obo:TXPO_0003577c
obo:TXPO_0003581c

increasing blood glucose level [diabetes coruse]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003290
Super-classes obo:TXPO_0001912c
obo:TXPO_0003342c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002033c
Sub-classes obo:TXPO_0003340c

diabetic retinopathy coursec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003291
Super-classes obo:TXPO_0002033c
Restrictions obo:BFO_0000051op some obo:TXPO_0003295c
obo:BFO_0000051op some obo:TXPO_0003294c
obo:BFO_0000051op some obo:TXPO_0003317c
obo:BFO_0000051op some obo:TXPO_0003340c

microvascular dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003292
Super-classes obo:TXPO_0002073c

narrowing of the retinal arteryc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003293
Super-classes obo:TXPO_0002648c
Restrictions obo:RO_0002234op some (obo:UBERON_0003501c and ub744bL87476C17c)
Sub-classes obo:TXPO_0003294c

narrowing of the retinal artery [Diabetic retinopathy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003294
Super-classes obo:TXPO_0003342c
obo:TXPO_0003293c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003317c
obo:TXPO_0000774op only obo:TXPO_0003291c

retinal degeneration [Diabetic retinopathy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003295
Super-classes obo:TXPO_0001470c
obo:TXPO_0003342c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003291c

regulation of cell cycle [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003296
Super-classes obo:GO_0051726c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003298c
obo:TXPO_0000774op only obo:TXPO_0003233c

increasing hepatocellular volume [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003297
Super-classes obo:TXPO_0000164c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003271c
obo:BFO_0000051op some obo:TXPO_0003314c
obo:BFO_0000051op some obo:TXPO_0003304c
obo:TXPO_0000774op only obo:TXPO_0003233c

cell division [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003298
Super-classes obo:TXPO_0003279c
obo:GO_0051301c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003319c
obo:TXPO_0000774op only obo:TXPO_0003233c

water accumulation [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003299
Super-classes obo:TXPO_0001216c
obo:TXPO_0003279c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
obo:BFO_0000051op some obo:TXPO_0003309c
obo:TXPO_0000774op only obo:TXPO_0003233c
obo:BFO_0000051op some obo:TXPO_0003316c
obo:TXPO_0000069op some obo:TXPO_0003297c

peroxisomal proliferation in hepatocyte [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003300
Super-classes obo:TXPO_0003279c
obo:TXPO_0000104c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c

mitochondria proliferation in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003301
Super-classes obo:TXPO_0003303c
Restrictions obo:RO_0002234op some (obo:GO_0005739c and ub744bL87612C17c)
Sub-classes obo:TXPO_0003302c

mitochondria proliferation in hepatocyte [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003302
Super-classes obo:TXPO_0003279c
obo:TXPO_0003301c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c

hepatocyte organelle proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003303
Super-classes obo:TXPO_0000108c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0000091c
obo:TXPO_0003301c
obo:TXPO_0000104c
obo:TXPO_0000692c
obo:TXPO_0003304c

hepatocyte organelle proliferation [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003304
Super-classes obo:TXPO_0003303c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c
obo:BFO_0000051op some obo:TXPO_0003300c
obo:BFO_0000051op some obo:TXPO_0003302c
obo:TXPO_0000069op some obo:TXPO_0003297c
obo:BFO_0000051op some obo:TXPO_0003305c

smooth endoplasmic reticulum proliferation in hepatocyte [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003305
Super-classes obo:TXPO_0003279c
obo:TXPO_0001230c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003233c

increasing osmotic pressure.c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003306
Super-classes obo:TXPO_0001689c
Sub-classes obo:TXPO_0003308c

decreasing osmotic pressure.c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003307
Super-classes obo:TXPO_0001913c
Sub-classes obo:TXPO_0001333c

increasing osmotic pressure in cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003308
Super-classes obo:TXPO_0003306c
Sub-classes obo:TXPO_0003309c

increasing osmotic pressure in cell [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003309
Super-classes obo:TXPO_0003279c
obo:TXPO_0003308c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003316c
obo:BFO_0000066op some obo:CL_0000182c
obo:TXPO_0000774op only obo:TXPO_0003233c

lipid strorage in hepatocyte [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003310
Super-classes obo:TXPO_0003623c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003297c
obo:TXPO_0000774op only obo:TXPO_0003233c

improvingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003311
Super-classes obo:TXPO_0002541c

increasing number of dead cells in liver [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003312
Super-classes obo:TXPO_0000341c
obo:TXPO_0000034c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0001277c

accumulation of substance in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003313
Super-classes obo:TXPO_0000247c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0003314c

accumulation of substance in hepatocyte [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003314
Super-classes obo:TXPO_0003313c
obo:TXPO_0003279c
Restrictions obo:BFO_0000051op some obo:TXPO_0003299c
obo:TXPO_0000774op only obo:TXPO_0003233c
obo:TXPO_0000069op some obo:TXPO_0003297c
obo:BFO_0000051op some obo:TXPO_0001266c
obo:BFO_0000051op some obo:TXPO_0003310c

decreasing retinal blood flowc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003315
Super-classes obo:TXPO_0000359c
Sub-classes obo:TXPO_0003317c

moving water to the inside of cell [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003316
Super-classes obo:TXPO_0003318c
obo:TXPO_0003279c
Restrictions obo:BFO_0000066op some obo:CL_0000182c
obo:TXPO_0000774op only obo:TXPO_0003233c
obo:TXPO_0000069op some obo:TXPO_0003299c

decreasing retinal blood flow [Diabetic retinopathy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003317
Super-classes obo:TXPO_0003315c
obo:TXPO_0003342c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003295c
obo:TXPO_0000774op only obo:TXPO_0003291c

moving water to the inside of cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003318
Super-classes obo:TXPO_0002587c
Restrictions obo:BFO_0000066op some obo:CL_0000000c
Sub-classes obo:TXPO_0003316c

cell growth [Hypertrophy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003319
Super-classes obo:GO_0016049c
obo:TXPO_0003279c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003297c
obo:TXPO_0000774op only obo:TXPO_0003233c

FNDC4 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003320
Super-classes obo:TXPO_0002668c
obo:TXPO_1000150c
Restrictions obo:TXPO_0000756op some obo:TXPO_0001442c
obo:TXPO_0000819op some obo:OGG_3000064838c

ceramidasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003321
Super-classes obo:TXPO_0003663c

SMPDL3A (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003322
Super-classes obo:TXPO_1000348c
obo:TXPO_0002668c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010924c
obo:TXPO_0000756op some obo:TXPO_0001442c

GDPD1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003323
Super-classes obo:TXPO_0002668c
obo:TXPO_1000165c
Restrictions obo:RO_0000087op some obo:TXPO_0003672c
obo:TXPO_0000819op some obo:OGG_3000284161c
obo:TXPO_0000756op some obo:TXPO_0001442c

AP1S1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003324
Super-classes obo:TXPO_1000004c
obo:TXPO_0002668c
Restrictions obo:RO_0000087op some obo:TXPO_0003638c
obo:TXPO_0000819op some obo:OGG_3000001174c
obo:TXPO_0000756op some obo:TXPO_0001442c

ELOVL6 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003325
Description

The birth rate of Elovl6 knockout mice was lower, and the surviving mice were smaller in size and had reduced body weight. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Secondary regulation of PPARa activity could be a part of SREBP-1c/Elovl6 regulation of lipogenesis.
Super-classes obo:TXPO_0002668c
obo:TXPO_0000372c
obo:TXPO_1000125c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079071c
obo:RO_0000087op some obo:TXPO_0003326c
obo:TXPO_0000756op some obo:TXPO_0001442c

fatty acid elongasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003326
Description

related molecular function GO:0009922
Super-classes obo:IMR_0010252c

SCD (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003327
Super-classes obo:TXPO_0002668c
obo:TXPO_0000587c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006319c
obo:RO_0000087op some obo:TXPO_0003329c
obo:TXPO_0000756op some obo:TXPO_0001442c

acyl-coA desaturasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003328
Description

related molecular function GO:0016215
Super-classes obo:TXPO_0000519c
Sub-classes obo:TXPO_0003348c
obo:TXPO_0003329c

stearoyl-CoA 9-desaturasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003329
Description

related molecular function GO:0004768
Super-classes obo:TXPO_0003328c

LSS (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003330
Super-classes obo:TXPO_0002668c
obo:TXPO_1000228c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004047c
obo:TXPO_0000756op some obo:TXPO_0001442c

cytokine receptorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003331
Description

related molecular function GO:0004896
Super-classes obo:TXPO_0000057c

cholesterol biosynthetic process [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003332
Description

The chemical reaction resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
Super-classes obo:GO_0006695c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003330c

NR0B2 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003333
Super-classes obo:OGG_3000008431c
obo:TXPO_0002668c
Restrictions obo:TXPO_0000756op some obo:TXPO_0001442c
obo:RO_0000087op some obo:TXPO_0003224c
obo:TXPO_0000819op some obo:OGG_3000008431c

TAGLN (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003334
Description

This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
Super-classes obo:TXPO_1000369c
obo:TXPO_0002668c
Restrictions obo:TXPO_0000756op some obo:TXPO_0001442c
obo:TXPO_0000819op some obo:OGG_3000006876c

SLC2A3 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003335
Super-classes obo:TXPO_1000342c
obo:TXPO_0002668c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006515c
obo:TXPO_0000756op some obo:TXPO_0001442c
obo:RO_0000087op some obo:TXPO_0003336c

glucose transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003336
Description

related molecular function GO:0005355
Super-classes obo:TXPO_0003701c

FABP1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003337
Super-classes obo:TXPO_0002668c
obo:TXPO_1000137c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002168c
obo:RO_0000087op some obo:TXPO_0003338c
obo:TXPO_0000756op some obo:TXPO_0001442c

long-chain fatty acid transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003338
Description

related molecular function GO:0005324
Super-classes obo:TXPO_0003699c

SERPINA3 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003339
Super-classes obo:TXPO_1000336c
obo:TXPO_0002668c
Restrictions obo:TXPO_0000756op some obo:TXPO_0001442c
obo:TXPO_0000819op some obo:OGG_3000000012c

increasing blood glucose level [Diabetic retinopathy]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003340
Super-classes obo:TXPO_0003290c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003294c
obo:TXPO_0000774op only obo:TXPO_0003291c

EGR1 (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003341
Super-classes obo:TXPO_0000793c
obo:IMR_0000403c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

Diabetes dependent process [diabetes course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003342
Super-classes obo:TXPO_0000808c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002033c
Sub-classes obo:TXPO_0002437c
obo:TXPO_0003294c
obo:TXPO_0002435c
obo:TXPO_0002443c
obo:TXPO_0003290c
obo:TXPO_0003576c
obo:TXPO_0003295c
obo:TXPO_0003289c
obo:TXPO_0003317c

binding to DNA by electrophilesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003343
Super-classes obo:GO_0005488c
Sub-classes obo:TXPO_0004244c
obo:TXPO_0003344c

binding to DNA by electrophiles [cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003344
Super-classes obo:TXPO_0001727c
obo:TXPO_0003343c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000773c
obo:TXPO_0000774op only obo:TXPO_0000323c

CAD [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003345
Super-classes obo:TXPO_0003353c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0001426c

FADS2 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003346
Description

The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Super-classes obo:TXPO_0003213c
obo:TXPO_0000321c
Restrictions obo:RO_0000087op some obo:TXPO_0003348c
obo:TXPO_0000756op some obo:TXPO_0000489c

FABP5 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003347
Super-classes obo:TXPO_0003213c
obo:TXPO_1000153c

linoleoyl-CoA desaturase rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003348
Description

related molecular function GO:0016213
Super-classes obo:TXPO_0003328c

S1P[Phospholipidosis - tumor proliferation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003349
Super-classes obo:CHEBI_37550c
obo:TXPO_0001849c
Restrictions obo:RO_0000087op some obo:TXPO_0002272c

ASAH1 (human)[Phospholipidosis - insulin resistance inhibition]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003350
Super-classes obo:TXPO_0000529c
Restrictions obo:RO_0000087op some obo:TXPO_0003351c

inhibitor of insulin resistancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003351
Super-classes obo:TXPO_0003230c

negative regulation of increasing insulin resistance [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003352
Super-classes obo:TXPO_0001716c
obo:TXPO_0002537c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003350c

substance with cationic amphiphilic drug rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003353
Description

This entity is inferred from Description Logic.
Super-classes obo:GOCHE_50906c
Restrictions obo:RO_0000086op some obo:PATO_0001886c
obo:RO_0000086op some obo:PATO_0001884c
Sub-classes obo:TXPO_0003345c

lysosomal enzyme transport (to lysosome) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003354
Super-classes obo:TXPO_0001716c
obo:TXPO_0003355c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001406c
obo:BFO_0000066op some obo:GO_0005770c
obo:TXPO_0000774op only obo:TXPO_0002215c

transportng lysosomal enzyme from ribosome to lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003355
Super-classes obo:GO_0006810c
Restrictions obo:RO_0002338op some obo:GO_0005840c
obo:BFO_0000066op some obo:GO_0005770c
obo:RO_0002339op some obo:GO_0005764c
Sub-classes obo:TXPO_0003354c

phospholipidosis (normal course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003356
Super-classes obo:TXPO_0003382c
Restrictions obo:BFO_0000051op some obo:TXPO_0001435c
obo:TXPO_0000004op some obo:TXPO_0001772c
obo:BFO_0000051op some obo:TXPO_0001772c
obo:BFO_0000051op some obo:TXPO_0001683c

keeping amount of phospholipid in lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003357
Super-classes obo:TXPO_0000414c
Sub-classes obo:TXPO_0003358c

keeping amount of phospholipid in lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003358
Super-classes obo:TXPO_0001716c
obo:TXPO_0003357c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0001772c

phospholipidosis (mild)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003359
Super-classes obo:TXPO_0002215c
Restrictions obo:BFO_0000051op some obo:TXPO_0002087c
obo:TXPO_0000004op only obo:TXPO_0001777c
obo:BFO_0000051op some obo:TXPO_0001241c
obo:BFO_0000051op some obo:TXPO_0001777c
obo:BFO_0000051op some obo:TXPO_0001824c
obo:BFO_0000051op some obo:TXPO_0002088c
obo:BFO_0000051op some obo:TXPO_0003453c
obo:BFO_0000051op some obo:TXPO_0004155c

dysfunction of fatty acid degradation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003361
Super-classes obo:TXPO_0001036c
obo:TXPO_0001720c
Restrictions obo:BFO_0000051op some obo:TXPO_0001126c
obo:BFO_0000051op some obo:TXPO_0001539c
obo:TXPO_0000069op some obo:TXPO_0001044c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000066op some obo:CL_0000182c
Sub-classes obo:TXPO_0000279c

CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003362
Super-classes obo:TXPO_0001399c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003359c
obo:RO_0000057op some obo:TXPO_0001560c
obo:RO_0002212op some obo:TXPO_0003404c
obo:TXPO_0000069op some obo:TXPO_0003412c

forming a complex of CAD and phospholipid [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003363
Super-classes obo:TXPO_0003364c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001560c

forming a complex of CAD and phospholipidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003364
Description

CAD decreases phospholipid release for cell membrane repair from lysosome.
Super-classes obo:TXPO_0001254c
Restrictions obo:RO_0002233op some obo:CHEBI_16247c
obo:RO_0002233op some (obo:BFO_0000002c and ub744bL88522C17c)
Sub-classes obo:TXPO_0003565c
obo:TXPO_0003363c
obo:TXPO_0003566c
obo:TXPO_0003567c

forming a complex of CAD and phospholipid [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003365
Super-classes obo:TXPO_0003567c
Restrictions obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0000010c
obo:TXPO_0000069op some obo:TXPO_0001262c

hypofunction of phospholipid export from lysosome [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003366
Super-classes obo:TXPO_0001261c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0003370c
obo:TXPO_0000716op some obo:TXPO_0000200c

CAD accumulation in lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003367
Super-classes obo:TXPO_0001716c
obo:TXPO_0001240c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001551c
obo:TXPO_0000069op some obo:TXPO_0003414c
obo:BFO_0000066op some obo:GO_0005764c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0000313c
obo:RO_0000057op some obo:TXPO_0001560c
obo:RO_0000057op some obo:TXPO_0000317c
obo:RO_0000057op some obo:TXPO_0000499c
Sub-classes obo:TXPO_0002522c
obo:TXPO_0002214c
obo:TXPO_0001241c
obo:TXPO_0003451c

CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003368
Super-classes obo:TXPO_0001399c
Restrictions obo:RO_0002212op some obo:TXPO_0003404c
obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0003443c

phospholipidosis (moderate)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003369
Super-classes obo:TXPO_0002215c
Restrictions obo:BFO_0000051op some obo:TXPO_0003370c
obo:BFO_0000051op some obo:TXPO_0003282c
obo:BFO_0000051op some obo:TXPO_0001704c
obo:BFO_0000051op some obo:TXPO_0001822c
obo:BFO_0000051op some obo:TXPO_0002086c
obo:BFO_0000051op some obo:TXPO_0003366c
obo:TXPO_0000004op only obo:TXPO_0003372c
obo:BFO_0000051op some obo:TXPO_0001702c
obo:BFO_0000051op some obo:TXPO_0003454c
obo:BFO_0000051op some obo:TXPO_0002214c
obo:BFO_0000051op some obo:TXPO_0001761c
obo:BFO_0000051op some obo:TXPO_0003371c
obo:BFO_0000051op some obo:TXPO_0001700c
obo:BFO_0000051op some obo:TXPO_0003372c
Sub-classes obo:TXPO_0000949c

phospholipid homeostasis imbalance [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003370
Super-classes obo:TXPO_0000907c
Restrictions obo:BFO_0000051op some obo:TXPO_0003372c
obo:TXPO_0001733op some obo:TXPO_0000680c
obo:TXPO_0000716op some obo:TXPO_0001683c
obo:TXPO_0000069op some obo:TXPO_0003371c
obo:TXPO_0000774op only obo:TXPO_0003369c

phospholipid accumulation in lysosome [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003371
Super-classes obo:TXPO_0000910c
Restrictions obo:RO_0000086op only obo:TXPO_0000854c
obo:TXPO_0000774op only obo:TXPO_0003369c

phospholipid metabolism imbalance [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003372
Super-classes obo:TXPO_0002324c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003369c
obo:TXPO_0000716op some obo:TXPO_0001435c
obo:TXPO_0000069op some obo:TXPO_0003371c
obo:TXPO_0000069op some obo:TXPO_0003370c
obo:TXPO_0001733op some obo:TXPO_0000680c

glycerophospholipid accumulation in lysosome [Phospholipidosis - glycerophospholipid disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003373
Super-classes obo:TXPO_0001697c

phosphatidylinositol accumulation in lysosome [Phospholipidosis - phosphatidylinositol disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003374
Super-classes obo:TXPO_0001831c

phosphatidylethanolamine accumulation in lysosome [Phospholipidosis - phosphatidylethanolamine disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003375
Super-classes obo:TXPO_0001709c

phosphatidylglycerol accumulation in lysosome [Phospholipidosis - phosphatidylglycerol disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003376
Super-classes obo:TXPO_0001707c

phosphatidylcholine accumulation in lysosome [Phospholipidosis - phosphatidylcholine disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003377
Super-classes obo:TXPO_0001705c

phosphatidylserine accumulation in lysosome [Phospholipidosis - phosphatidylserine disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003378
Super-classes obo:TXPO_0001703c

phosphatidic acid accumulation in lysosome [Phospholipidosis - phosphatidic acid disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003379
Super-classes obo:TXPO_0001701c

SGPL1 - apoptosis inducer (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003380
Super-classes obo:TXPO_0002090c
Restrictions obo:RO_0000056op some obo:TXPO_0000928c
obo:RO_0000087op some obo:TXPO_0002358c
obo:RO_0000087op some obo:CHEBI_68495c
obo:RO_0000056op some obo:TXPO_0001547c
obo:TXPO_0000756op some ncicp:C15958c

sphingomyelin accumulation in lysosome [Phospholipidosis - sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003381
Super-classes obo:TXPO_0000910c
obo:TXPO_0001764c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004157c
Sub-classes obo:TXPO_0001690c

phospholipidosis (course)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003382
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0000951c
obo:BFO_0000051op some obo:TXPO_0000946c
obo:TXPO_0000004op some obo:TXPO_0000946c
Sub-classes obo:TXPO_0001964c
obo:TXPO_0002215c
obo:TXPO_0003356c

phosholipase gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003383
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0003384c

phosholipase gene expression [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003384
Super-classes obo:TXPO_0001716c
obo:TXPO_0003383c
Restrictions obo:BFO_0000066op some obo:GO_0005634c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001406c

hyperfunction of phospholipid synthesis gene expression [Phospholipidosis - normal]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003385
Super-classes obo:TXPO_0001716c
obo:TXPO_0001726c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003356c

increasing phospholipid [Phospholipidosis (normal condition)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003386
Super-classes obo:TXPO_0001716c
obo:TXPO_0001250c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0003403c
obo:BFO_0000051op some obo:TXPO_0003387c
obo:BFO_0000051op some obo:TXPO_0003401c
obo:BFO_0000051op some obo:TXPO_0004136c
obo:BFO_0000051op some obo:TXPO_0003397c
obo:BFO_0000051op some obo:TXPO_0001427c
obo:BFO_0000051op some obo:TXPO_0003400c

phospholipid biosynthetic process [Phospholipidosis(normal)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003387
Super-classes obo:GO_0008654c
obo:TXPO_0001716c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0003356c
obo:TXPO_0000069op some obo:TXPO_0001435c

phospholipid transport from lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003388
Super-classes obo:GO_0015914c
Restrictions obo:RO_0002338op some obo:GO_0005764c
obo:RO_0002339op some obo:GO_0005829c
Sub-classes obo:TXPO_0000200c

Cyp3a11 (mouse)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003389
Super-classes obo:TXPO_0002285c
obo:TXPO_1000106c

decreasing number of cells [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003390
Super-classes obo:TXPO_0000351c
obo:TXPO_0001716c
Restrictions obo:BFO_0000051op some obo:TXPO_0003391c
obo:TXPO_0000774op only obo:TXPO_0002215c

apoptotic process [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003391
Super-classes obo:TXPO_0001716c
obo:GO_0006915c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

hyperfunctioning of apoptotic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003392
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0006915c

decreasing number of lysosomesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003393
Super-classes obo:TXPO_0000348c
Restrictions obo:RO_0002234op some (obo:GO_0005764c and ub744bL89034C17c)
Sub-classes obo:TXPO_0003394c

decreasing number of lysosomes [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003394
Super-classes obo:TXPO_0001716c
obo:TXPO_0003393c
Restrictions obo:BFO_0000051op some obo:TXPO_0001298c
obo:TXPO_0000774op only obo:TXPO_0002215c

removing phospholipid by Kupffer cell or macrophage [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003395
Super-classes obo:TXPO_0003396c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003356c

removing phospholipid by Kupffer cell or macrophagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003396
Super-classes obo:TXPO_0000458c
Restrictions obo:RO_0000057op some obo:CL_0000235c
obo:RO_0000057op some obo:CL_0000091c
Sub-classes obo:TXPO_0003395c

phospholipid synthesis gene expression [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003397
Super-classes obo:TXPO_0003398c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003387c
obo:TXPO_0000774op only obo:TXPO_0002215c

phospholipid synthesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003398
Super-classes obo:GO_0010467c
Sub-classes obo:TXPO_0003397c

positive regulation of phospholipid biosynthetic process [Phospholipidosis (normal)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003400
Super-classes obo:GO_0071073c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0003385c

moving phopholipid to lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003401
Super-classes obo:TXPO_0001716c
obo:TXPO_0003402c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

moving phopholipid to lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003402
Super-classes obo:TXPO_0002587c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
obo:RO_0002233op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0003401c

increasing phospholipid material (normal condition) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003403
Super-classes obo:TXPO_0001716c
obo:TXPO_0001314c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0003387c

phosphholipid binding by phospholipase [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003404
Super-classes obo:TXPO_0001716c
obo:TXPO_0003640c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0003410c

IL-2 signaling (primitive) [Phospholipidosis (excessive defense) - inflammation ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003405
Super-classes obo:TXPO_0000833c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003408c
obo:RO_0000057op some obo:TXPO_0003426c

IL-2 signaling (primitive) [Phospholipidosis (excessive defense) - apoptosis inhibition ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003406
Super-classes obo:TXPO_0000833c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001495c
obo:RO_0000057op some obo:TXPO_0003427c
obo:RO_0000057op some obo:TXPO_0002267c
obo:TXPO_0000774op only obo:TXPO_0002215c

IL-2 signaling (primitive) [Phospholipidosis (excessive defense) - cell cycle arrest ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003407
Super-classes obo:TXPO_0000833c
Restrictions obo:RO_0000057op some obo:TXPO_0002268c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001495c
obo:RO_0000057op some obo:TXPO_0003429c

IL2RB (human)[Phospholipidosis - inflammation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003408
Super-classes obo:TXPO_0001143c
Restrictions obo:RO_0000056op some obo:TXPO_0001488c
obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:TXPO_0003041c
obo:RO_0000056op some obo:TXPO_0000833c

PPARA - glucose metabolism regulator (canonical)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003409
Super-classes obo:TXPO_0001328c
Restrictions obo:RO_0000087op some obo:TXPO_0003949c

phospholipid hydrolysis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003410
Description

phospholipase activity http://purl.obolibrary.org/obo/GO_0004620
Super-classes obo:TXPO_0001716c
obo:TXPO_0003411c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

phospholipid hydrolysisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003411
Super-classes obo:NCIT_C16702c
Restrictions obo:RO_0002233op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0003410c

negative regulation of phospholipid hydrolysis [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003412
Super-classes obo:TXPO_0003448c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003359c
obo:RO_0002212op some obo:TXPO_0003410c
obo:TXPO_0000069op some obo:TXPO_0001403c

negative regulation of phospholipid hydrolysisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003413
Super-classes obo:TXPO_0001256c
Sub-classes obo:TXPO_0003448c

negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003414
Super-classes obo:TXPO_0001716c
obo:TXPO_0003446c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0001868op some obo:TXPO_0000319c
obo:TXPO_0001868op some obo:TXPO_0003227c
obo:TXPO_0001868op some obo:TXPO_0003228c
obo:TXPO_0000069op some obo:TXPO_0000905c
Sub-classes obo:TXPO_0001403c
obo:TXPO_0003450c
obo:TXPO_0003442c
obo:TXPO_0001908c

AKT signaling (primitive) [phospholipidosis (excessive defense) - cell proliferation ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003415
Super-classes obo:TXPO_0001796c
Restrictions obo:TXPO_0000076op some obo:TXPO_0001495c
obo:RO_0000057op some obo:TXPO_0001137c
obo:TXPO_0000774op only obo:TXPO_0001490c
obo:RO_0000057op some obo:TXPO_0001857c
obo:RO_0000057op some obo:TXPO_0001175c
obo:RO_0000057op some obo:TXPO_0003229c

AKT signaling (primitive) [Phospholipidosis (excessive defense) - tumor cell proliferation ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003416
Super-classes obo:TXPO_0001796c
Restrictions obo:RO_0000057op some obo:TXPO_0003417c
obo:RO_0000057op some obo:TXPO_0001175c
obo:RO_0000057op some obo:TXPO_0001137c
obo:RO_0000057op some obo:TXPO_0001857c
obo:RO_0000057op some obo:TXPO_0004106c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003559c
obo:TXPO_0000076op some obo:TXPO_0001495c
obo:TXPO_0000069op some obo:TXPO_0001491c

AKT - tumor cell proliferation promoting factor (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003417
Super-classes obo:TXPO_0001799c
Restrictions obo:RO_0000087op some obo:TXPO_0002272c
obo:TXPO_0002260op some obo:IMR_0000250c

phosphatidylinositol 3-kinase signaling (primitive) [Phospholipidosis (excessive defense) - cell proliferation ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003418
Super-classes obo:TXPO_0001495c
Restrictions obo:RO_0000057op some obo:TXPO_0003419c
obo:RO_0000057op some obo:TXPO_0001137c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001796c
obo:RO_0000057op some obo:TXPO_0001175c
obo:RO_0000057op some obo:TXPO_0001857c

PI3K - cell proliferation promoting factor (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003419
Super-classes obo:TXPO_0001800c
Restrictions obo:RO_0000087op some obo:TXPO_0002271c
obo:TXPO_0002260op some obo:IMR_0000265c

PI3K - tumor cell proliferation promoting factor (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003420
Super-classes obo:TXPO_0001800c
Restrictions obo:TXPO_0002260op some obo:IMR_0000265c
obo:RO_0000087op some obo:TXPO_0002272c

phosphatidylinositol 3-kinase signaling (primitive) [Phospholipidosis (excessive defense) - tumor cell proliferation ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003421
Super-classes obo:TXPO_0001495c
Restrictions obo:RO_0000057op some obo:TXPO_0001137c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001175c
obo:TXPO_0000069op some obo:TXPO_0003416c
obo:RO_0000057op some obo:TXPO_0003420c
obo:RO_0000057op some obo:TXPO_0001857c

EGFR signaling (primitive) [Phospholipidosis (excessive defense) - cell proliferation ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003422
Super-classes obo:TXPO_0001493c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001798c
obo:RO_0000057op some obo:TXPO_0001175c
obo:RO_0000057op some obo:TXPO_0001137c
obo:TXPO_0000069op some obo:TXPO_0003418c

EGFR signaling (primitive) [Phospholipidosis (excessive defense) - tumor cell proliferation ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003423
Super-classes obo:TXPO_0001493c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0001798c
obo:RO_0000057op some obo:TXPO_0001137c
obo:TXPO_0000069op some obo:TXPO_0003421c
obo:RO_0000057op some obo:TXPO_0001175c

EGFR (canonical)[Phospholipidosis - cell proliferation factor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003424
Super-classes obo:TXPO_0001798c
Restrictions obo:RO_0000087op some obo:TXPO_0002271c
obo:TXPO_0002260op some obo:IMR_0000081c

EGFR (canonical)[Phospholipidosis - tumor cell proliferation factor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003425
Super-classes obo:TXPO_0001798c
Restrictions obo:TXPO_0002260op some obo:IMR_0000081c
obo:RO_0000087op some obo:TXPO_0002272c

IL2 (canonical)[Phospholipidosis - inflammatory cytokine]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003426
Super-classes obo:TXPO_0002288c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c
obo:TXPO_0002260op some obo:IMR_0000008c

IL2 (canonical)[Phospholipidosis - apotosis inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003427
Super-classes obo:TXPO_0002288c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c
obo:TXPO_0002260op some obo:IMR_0000008c

IL2 (canonical)[Phospholipidosis - tumor cell proliferation promoting factor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003428
Super-classes obo:TXPO_0002288c
Restrictions obo:RO_0000087op some obo:TXPO_0002272c
obo:TXPO_0002260op some obo:IMR_0000008c

IL2 (canonical)[Phospholipidosis - cell cycle progression promoting factor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003429
Super-classes obo:TXPO_0002288c
Restrictions obo:RO_0000087op some obo:TXPO_0002269c
obo:TXPO_0002260op some obo:IMR_0000008c

kupffer cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003430
Description

The process in which a relatively unspecialized monocyte acquires the specialized features of a Kupffer cell.
Super-classes obo:GO_0030225c

hyperfunction of phospholipid phagocytosis by Kupffer cells [Phospholipidosis (excessive defense)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003431
Super-classes obo:TXPO_0003432c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:RO_0000057op some obo:CL_0000091c
obo:TXPO_0000716op some obo:TXPO_0003395c
obo:TXPO_0000069op some obo:TXPO_0000558c
obo:RO_0000057op some obo:CL_0000235c

hyperfunction of phospholipid phagocytosis by Kupffer cellsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003432
Super-classes obo:TXPO_0001483c
Restrictions obo:TXPO_0001502op some obo:TXPO_0003396c
Sub-classes obo:TXPO_0003431c

hyperfunction of cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003433
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0030154c
Sub-classes obo:TXPO_0003434c

hyperfunction of Kupffer cell differentiationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003434
Super-classes obo:TXPO_0003433c
Sub-classes obo:TXPO_0000636c

phospholipid homeostasis imbalance [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003435
Super-classes obo:TXPO_0000907c
Restrictions obo:BFO_0000051op some obo:TXPO_0001778c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0001733op some (obo:TXPO_0000679c or obo:TXPO_0001779c)
obo:TXPO_0000069op some obo:TXPO_0000920c
obo:TXPO_0000716op some obo:TXPO_0001683c

decreasing lysosomal membrane permeability [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003436
Super-classes obo:TXPO_0003438c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0002239c
obo:BFO_0000066op some obo:GO_0005765c

in vitro (human) 8hrc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003437
Super-classes obo:TXPO_0000795c

decreasing lysosomal membrane permeabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003438
Super-classes obo:TXPO_0003439c
Sub-classes obo:TXPO_0003436c

decreasing membrane permeabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003439
Super-classes obo:TXPO_0002704c
Sub-classes obo:TXPO_0003438c

hyperfunction of phospholipid material transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003440
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:TXPO_0002225c
Sub-classes obo:TXPO_0002226c

pattern recognition receptorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003441
Description

related molecular function GO:0038187
Super-classes obo:TXPO_0002463c

negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003442
Super-classes obo:TXPO_0003414c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003444c
obo:TXPO_0001868op some obo:TXPO_0000319c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000012op some obo:TXPO_0003368c
obo:TXPO_0001868op some obo:TXPO_0003228c
obo:TXPO_0000012op some obo:TXPO_0003443c
obo:TXPO_0001868op some obo:TXPO_0003227c

negative regulation of phospholipid hydrolysis [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003443
Super-classes obo:TXPO_0003448c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003442c
obo:RO_0002212op some obo:TXPO_0003410c
obo:TXPO_0000774op only obo:TXPO_0003369c

negative regulation of phospholipid degradation [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003444
Super-classes obo:TXPO_0000905c
Restrictions obo:BFO_0000051op some obo:TXPO_0003442c
obo:TXPO_0000774op only obo:TXPO_0003369c
obo:TXPO_0000069op some obo:TXPO_0003282c
obo:TXPO_0000069op some obo:TXPO_0003372c

hypofunction of ceramide degradation [sphingomyelin disorder ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003445
Super-classes obo:TXPO_0001829c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004157c
obo:RO_0000057op some obo:TXPO_0003456c

negative regulation of phospholipase-mediated phospholipid degradation by CADc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003446
Super-classes obo:TXPO_0001256c
Restrictions obo:RO_0002212op some obo:GO_0009395c
Sub-classes obo:TXPO_0003414c

negative regulation of phospholipid hydrolysis [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003447
Super-classes obo:TXPO_0003448c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:RO_0002212op some obo:TXPO_0003410c
obo:TXPO_0000069op some obo:TXPO_0003450c

negative regulation of phospholipid hydrolysis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003448
Super-classes obo:TXPO_0001716c
obo:TXPO_0003413c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0003414c
Sub-classes obo:TXPO_0003443c
obo:TXPO_0003578c
obo:TXPO_0003447c
obo:TXPO_0003412c

CAD insertion into phospholipase binding site to lysosomal inner membrane [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003449
Super-classes obo:TXPO_0001399c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003450c
obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0002212op some obo:TXPO_0003404c

negative regulation of phospholipase-mediated phospholipid degradation by CAD [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003450
Super-classes obo:TXPO_0003414c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002217c
obo:TXPO_0001868op some obo:TXPO_0003227c
obo:TXPO_0001868op some obo:TXPO_0000319c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0001868op some obo:TXPO_0003228c
obo:TXPO_0000012op some obo:TXPO_0003449c
obo:TXPO_0000012op some obo:TXPO_0003447c
obo:TXPO_0000069op some obo:TXPO_0004032c

CAD accumulation in lysosome [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003451
Super-classes obo:TXPO_0003367c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003365c
obo:TXPO_0000069op some obo:TXPO_0003450c
obo:BFO_0000066op some obo:GO_0005764c
obo:RO_0000057op some obo:TXPO_0000081c
obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000774op only obo:TXPO_0003452c

phospholipidosis (severe)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003452
Super-classes obo:TXPO_0002215c
Restrictions obo:BFO_0000051op some obo:TXPO_0003877c
obo:BFO_0000051op some obo:TXPO_0000903c
obo:BFO_0000051op some obo:TXPO_0004001c
obo:BFO_0000051op some obo:TXPO_0000911c
obo:BFO_0000051op some obo:TXPO_0003886c
obo:TXPO_0000004op only obo:TXPO_0001778c
obo:BFO_0000051op some obo:TXPO_0001497c
obo:BFO_0000051op some obo:TXPO_0002276c
obo:BFO_0000051op some obo:TXPO_0003451c
obo:BFO_0000051op some obo:TXPO_0004144c
obo:BFO_0000051op some obo:TXPO_0001257c
obo:BFO_0000051op some obo:TXPO_0001698c
obo:BFO_0000051op some obo:TXPO_0001844c
obo:BFO_0000051op some obo:TXPO_0000539c
obo:BFO_0000051op some obo:TXPO_0001708c
obo:BFO_0000051op some obo:TXPO_0000928c
obo:BFO_0000051op some obo:TXPO_0002222c
obo:BFO_0000051op some obo:TXPO_0003592c
obo:BFO_0000051op some obo:TXPO_0000920c
obo:BFO_0000051op some obo:TXPO_0003824c
obo:BFO_0000051op some obo:TXPO_0002217c
obo:BFO_0000051op some obo:TXPO_0004132c
obo:BFO_0000051op some obo:TXPO_0001315c
obo:BFO_0000051op some obo:TXPO_0004069c
obo:BFO_0000051op some obo:TXPO_0001294c
obo:BFO_0000051op some obo:TXPO_0000558c
obo:BFO_0000051op some obo:TXPO_0002226c
obo:BFO_0000051op some obo:TXPO_0002098c
obo:BFO_0000051op some obo:TXPO_0000156c
obo:BFO_0000051op some obo:TXPO_0000797c
obo:BFO_0000051op some obo:TXPO_0002094c
obo:BFO_0000051op some obo:TXPO_0000717c
obo:BFO_0000051op some obo:TXPO_0002227c
obo:BFO_0000051op some obo:TXPO_0002239c
obo:BFO_0000051op some obo:TXPO_0001488c
obo:BFO_0000051op some obo:TXPO_0001400c
obo:BFO_0000051op some obo:TXPO_0002220c
obo:BFO_0000051op some obo:TXPO_0001778c
obo:BFO_0000051op some obo:TXPO_0001262c
obo:BFO_0000051op some obo:TXPO_0000912c
obo:BFO_0000051op some obo:TXPO_0004101c
obo:BFO_0000051op some obo:TXPO_0003435c
obo:BFO_0000051op some obo:TXPO_0001542c
obo:BFO_0000051op some obo:TXPO_0002297c
obo:BFO_0000051op some obo:TXPO_0003431c
obo:BFO_0000051op some obo:TXPO_0000923c
obo:BFO_0000051op some obo:TXPO_0004123c
obo:BFO_0000051op some obo:TXPO_0001695c
obo:BFO_0000051op some obo:TXPO_0003889c
obo:BFO_0000051op some obo:TXPO_0000555c
obo:BFO_0000051op some obo:TXPO_0000334c
obo:BFO_0000051op some obo:TXPO_0004065c
obo:BFO_0000051op some obo:TXPO_0004084c
obo:BFO_0000051op some obo:TXPO_0003594c
obo:BFO_0000051op some obo:TXPO_0004040c
obo:BFO_0000051op some obo:TXPO_0002097c
obo:BFO_0000051op some obo:TXPO_0000927c
obo:BFO_0000051op some obo:TXPO_0004010c
obo:BFO_0000051op some obo:TXPO_0004154c
obo:BFO_0000051op some obo:TXPO_0004148c
obo:BFO_0000051op some obo:TXPO_0003547c
obo:BFO_0000051op some obo:TXPO_0004053c

compound accumulation in lysosome [Phospholipidosis (mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003453
Super-classes obo:TXPO_0000930c
Restrictions obo:RO_0000057op some obo:TXPO_0001566c
obo:TXPO_0000069op some obo:TXPO_0002087c
obo:TXPO_0000774op only obo:TXPO_0003359c
obo:BFO_0000051op some obo:TXPO_0001241c
obo:RO_0000057op some obo:TXPO_0001425c
obo:RO_0000057op some obo:TXPO_0000081c
obo:RO_0000057op some obo:TXPO_0001560c

compound accumulation in lysosome [Phospholipidosis (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003454
Super-classes obo:TXPO_0000930c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003444c
obo:RO_0000057op some obo:TXPO_0001560c
obo:TXPO_0000774op only obo:TXPO_0003369c
obo:RO_0000057op some obo:TXPO_0001425c
obo:BFO_0000051op some obo:TXPO_0002214c

negative regulation of cell cycle gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003455
Super-classes obo:GO_0010629c
Sub-classes obo:TXPO_0002990c

ASAH1 - inactivated (human)[Phospholipidosis - hypofunctioning of ceramide degradation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003456
Super-classes obo:TXPO_0000529c
Restrictions obo:RO_0000087op some obo:TXPO_0003321c
obo:TXPO_0000756op some obo:TXPO_0001442c
obo:RO_0000087op some obo:TXPO_0003351c
obo:RO_0000086op some obo:PATO_0002355c

increasing hepatic portal pressure [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003457
Super-classes obo:TXPO_0003618c
obo:TXPO_0001359c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003461c
obo:TXPO_0000069op some obo:TXPO_0003462c
obo:TXPO_0000069op some obo:TXPO_0003466c
obo:TXPO_0000774op only obo:TXPO_0001357c
obo:TXPO_0000069op some obo:TXPO_0003463c

increasing hepatic venous pressure [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003458
Super-classes obo:TXPO_0003618c
obo:TXPO_0001366c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003459c
obo:TXPO_0000774op only obo:TXPO_0001357c

hyperfunction of hepatic lymph production [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003459
Super-classes obo:TXPO_0003618c
obo:TXPO_0001367c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003460c

hepatic lymph leakage [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003460
Super-classes obo:TXPO_0003618c
obo:TXPO_0001368c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c
obo:TXPO_0000069op some obo:TXPO_0003461c

ascites (process) [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003461
Super-classes obo:TXPO_0003618c
obo:TXPO_0001369c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c

inzreasing size of the spleen [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003462
Super-classes obo:TXPO_0001360c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c
obo:TXPO_0000069op some obo:TXPO_0003616c

stomach congestion [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003463
Super-classes obo:TXPO_0001365c
obo:TXPO_0003618c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c

intestine congestion [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003464
Super-classes obo:TXPO_0003465c
obo:TXPO_0003618c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c

intestine congestionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003465
Super-classes obo:TXPO_0000916c
Restrictions obo:BFO_0000066op some obo:UBERON_0000160c
Sub-classes obo:TXPO_0003464c

bypass formation [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003466
Super-classes obo:TXPO_0001363c
obo:TXPO_0003618c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c
obo:TXPO_0000069op some obo:TXPO_0003467c

varicosity of veins formation [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003467
Super-classes obo:TXPO_0001364c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c

sphingomyelinase gene mutation [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003468
Super-classes obo:TXPO_0001446c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003474c
obo:RO_0000057op some obo:TXPO_0003470c
obo:TXPO_0000774op only obo:TXPO_0001468c

SMPD1 (canonical)[Niemann Pick Disease Type A -B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003469
Super-classes obo:TXPO_0001464c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:TXPO_0003472c
obo:TXPO_0003470c

SMPD1 (canonical)[Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003470
Super-classes obo:TXPO_0003469c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c

DNAJB9 - apotosis repressor -vitro (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003471
Super-classes obo:TXPO_0002165c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c
obo:RO_0000087op some obo:CHEBI_68494c

SMPD1 (canonical)[Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003472
Super-classes obo:TXPO_0003469c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c

sphingomyelinase gene mutation [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003473
Super-classes obo:TXPO_0001446c
Restrictions obo:RO_0000057op some obo:TXPO_0003472c
obo:TXPO_0000069op some obo:TXPO_0003475c
obo:TXPO_0000774op only obo:TXPO_0001469c

dysfunction of sphingomyelin degradation [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003474
Super-classes obo:TXPO_0001475c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c
obo:BFO_0000051op some obo:TXPO_0001472c
obo:TXPO_0000069op some obo:TXPO_0001482c

dysfunction of sphingomyelin degradation [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003475
Super-classes obo:TXPO_0001475c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001469c
obo:TXPO_0000069op some obo:TXPO_0001816c

lipid accumulation in hepatocyte (severe) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003476
Super-classes obo:TXPO_0001129c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003495c
obo:TXPO_0000069op some obo:TXPO_0003512c
obo:TXPO_0001873op some obo:TXPO_0003541c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003478c
obo:TXPO_0000069op some obo:TXPO_0003480c
obo:TXPO_0000069op some obo:TXPO_0003511c
obo:BFO_0000051op some obo:TXPO_0001232c
obo:TXPO_0000069op some obo:TXPO_0000897c
obo:TXPO_0000069op some obo:TXPO_0003622c
Sub-classes obo:TXPO_0004210c

NRF2 (canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003477
Super-classes obo:TXPO_0003213c
obo:TXPO_0002527c

positive regulation of autophagy [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003478
Super-classes obo:TXPO_0001720c
obo:GO_0010508c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c

increasing hepatocellular volume [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003480
Super-classes obo:TXPO_0000164c
obo:TXPO_0001720c
Restrictions obo:TXPO_0001873op some obo:TXPO_0003628c
obo:TXPO_0000774op only obo:TXPO_0000888c

hyperfunction of glucose transport to liverc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003481
Super-classes obo:TXPO_0002351c
Restrictions obo:TXPO_0001502op some obo:GO_0008643c
Sub-classes obo:TXPO_0003482c

hyperfunction of glucose transport to liver [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003482
Super-classes obo:TXPO_0001720c
obo:TXPO_0003481c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0000890c

hypofunction of triglyceride transport from hepatocyte to extrahepaticc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003483
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:TXPO_0003486c
Sub-classes obo:TXPO_0001458c
obo:TXPO_0003484c

hypofunction of triglyceride transport from hepatocyte to extrahepatic [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003484
Super-classes obo:TXPO_0003483c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000716op some obo:TXPO_0003487c
obo:TXPO_0000069op some obo:TXPO_0003491c

HSP90B1 - apotosis repressor -vitro (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003485
Super-classes obo:TXPO_0000802c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000795c
obo:RO_0000087op only obo:CHEBI_68494c

triglyceride transport from hepatocyte to extrahepaticc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003486
Super-classes obo:GO_0034197c
Restrictions obo:RO_0002338op some obo:CL_0000182c
Sub-classes obo:TXPO_0003487c

triglyceride transport from hepatocyte to extrahepatic [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003487
Super-classes obo:TXPO_0001720c
obo:TXPO_0003486c
Restrictions obo:BFO_0000051op some obo:TXPO_0001281c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000051op some obo:TXPO_0001371c

lipid homeostasis imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003488
Description

lipid homeostasis imbalance
Super-classes obo:TXPO_0001656c
Sub-classes obo:TXPO_0000919c
obo:TXPO_0001043c
obo:TXPO_0004209c
obo:TXPO_0001038c
obo:TXPO_0002446c
obo:TXPO_0001243c
obo:TXPO_0003491c

GRP78 - apotosis repressor (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003489
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000087op only obo:CHEBI_68494c

tumor cell survial [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003490
Super-classes obo:TXPO_0001717c
obo:TXPO_0000280c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000057op some obo:TXPO_0003550c

lipid homeostasis imbalance [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003491
Super-classes obo:TXPO_0001163c
obo:TXPO_0003488c
Restrictions obo:BFO_0000051op some obo:TXPO_0000893c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001129c
Sub-classes obo:TXPO_0000919c
obo:TXPO_0001043c
obo:TXPO_0001038c
obo:TXPO_0001177c

increaing in fatty acid inflow into hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003492
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0001467c
obo:TXPO_0001673c
obo:TXPO_0000892c

increase in lipid inflow into hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003493
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0003494c

increase in lipid inflow into hepatocyte [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003494
Super-classes obo:TXPO_0003493c
obo:TXPO_0001720c
Restrictions obo:BFO_0000051op some obo:TXPO_0000892c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003491c
Sub-classes obo:TXPO_0003810c

necrosis [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003495
Super-classes obo:TXPO_0001720c
obo:GO_0070265c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000862c
obo:RO_0000057op some obo:TXPO_0000595c
obo:TXPO_0000774op only obo:TXPO_0000888c

insulin resistance (process) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003496
Super-classes obo:TXPO_0002189c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0001116c
Sub-classes obo:TXPO_0000809c

insulin deficiency [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003497
Super-classes obo:TXPO_0000072c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000890c
obo:TXPO_0000774op only obo:TXPO_0000888c

non-alcoholic fatty liver diseasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003498
Super-classes obo:TXPO_0000888c
()
Restrictions obo:BFO_0000051op some obo:TXPO_0003810c
obo:BFO_0000051op some obo:TXPO_0003808c
obo:BFO_0000051op some obo:TXPO_0001973c
obo:BFO_0000051op some obo:TXPO_0001116c
obo:BFO_0000051op some obo:TXPO_0001121c
obo:BFO_0000051op some obo:TXPO_0003806c
obo:BFO_0000051op some obo:TXPO_0000890c
obo:BFO_0000051op some obo:TXPO_0001113c
obo:BFO_0000051op some obo:TXPO_0001115c
obo:BFO_0000051op some obo:TXPO_0003811c
obo:BFO_0000051op some obo:TXPO_0003807c
obo:BFO_0000051op some obo:TXPO_0003496c
obo:BFO_0000051op some obo:TXPO_0003264c
obo:BFO_0000051op some obo:TXPO_0000898c
obo:BFO_0000051op some obo:TXPO_0003482c
obo:BFO_0000051op some obo:TXPO_0000901c
obo:BFO_0000051op some obo:TXPO_0003507c
obo:BFO_0000051op some obo:TXPO_0000891c
obo:BFO_0000051op some obo:TXPO_0003484c
obo:BFO_0000051op some obo:TXPO_0001129c
obo:BFO_0000051op some obo:TXPO_0003809c
obo:BFO_0000051op some obo:TXPO_0000899c
obo:BFO_0000051op some obo:TXPO_0000893c
obo:BFO_0000051op some obo:TXPO_0001117c
Sub-classes obo:TXPO_0001128c
obo:TXPO_0001127c

vacuolation [Liver Pathological Findings][Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003499
Description

A metabolic disorder of neutral fat causes fatty change. Lipid droplets consisting of large and small neutral fats (triglycerides) increase in the cytoplasm of hepatocytes. In the case of large lipid droplets, the uneven distribution of nuclei is observed, but in the case of small loose droplets (microvesicular fatty change), uneven distribution of nuclei is not observed. According to the distribution, it classifies into centrilobular, periportal, and diffuse type.
Super-classes obo:TXPO_0003524c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0003500op some obo:GO_0005737c
Sub-classes obo:TXPO_0003541c
obo:TXPO_0003540c
obo:TXPO_0003538c

eosinophilic granular degeneration [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003501
Super-classes obo:TXPO_0001507c
Sub-classes obo:TXPO_0003523c

hepatocellular hypertrophy [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003502
Super-classes obo:TXPO_0001507c
Restrictions obo:TXPO_0003500op some obo:CL_0000182c

cholestasis [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003503
Super-classes obo:TXPO_0001507c

hyperplasia [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003504
Super-classes obo:TXPO_0001507c

hepatic fibrosis [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003505
Super-classes obo:TXPO_0001507c
Restrictions obo:TXPO_0003500op some obo:UBERON_0002107c

hypofunction of lipoprotein biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003506
Super-classes obo:TXPO_0001958c
Restrictions obo:TXPO_0000716op some obo:GO_0042158c
Sub-classes obo:TXPO_0003507c

hypofunction of lipoprotein biosynthesis [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003507
Super-classes obo:TXPO_0003506c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003484c

lipidosis dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003508
Super-classes obo:TXPO_0001089c
Sub-classes obo:TXPO_0000787c
obo:TXPO_0002035c
obo:TXPO_0002013c
obo:TXPO_0003509c
obo:TXPO_0001634c
obo:TXPO_0003630c
obo:TXPO_0000670c
obo:TXPO_0002042c
obo:TXPO_0000880c

CCL4 [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003509
Super-classes obo:TXPO_0003508c
obo:CHEBI_27385c
Sub-classes obo:TXPO_0000595c
obo:TXPO_0000593c
obo:TXPO_0003748c

increasing demand for response to oxidative stress [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003510
Description

Because the mitochondrial pathway is saturated, fatty acids are metabolized in peroxisomes, and Cyp2E1 enzyme induction occurs, resulting in oxidative stress.
Super-classes obo:TXPO_0001720c
obo:TXPO_0000102c
Restrictions obo:BFO_0000051op some obo:TXPO_0001086c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003620c

malfunctioning of cellular membrane [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003511
Super-classes obo:TXPO_0002198c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0003495c
obo:BFO_0000051op some obo:TXPO_0003512c

cellular membrane lipoperoxidation [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003512
Super-classes obo:TXPO_0003513c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003510c
obo:TXPO_0000069op some obo:TXPO_0001086c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:RO_0000057op some obo:TXPO_0000593c

cellular membrane lipoperoxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003513
Super-classes obo:TXPO_0003514c
Sub-classes obo:TXPO_0003512c
obo:TXPO_0004343c

lipoperoxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003514
Super-classes obo:GO_0034440c
Sub-classes obo:TXPO_0004278c
obo:TXPO_0000543c
obo:TXPO_0005010c
obo:TXPO_0001200c
obo:TXPO_0003513c
obo:TXPO_0004932c

eosinophilic change [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003515
Description

· Stained with eosinophilic (eosinophilic) dye of hepatic cytoplasm. · Generally, it is caused by diffuse or focal increase of cytoplasmic organelle or excessive accumulation of eosinophilic substance.

· Eosinophilic staining area: It often corresponds to mitochondria, smooth endoplasmic reticulum, or peroxisome. · Changes over the entire cytoplasm: granule degeneration, eosinophilic granular change, glute-like change · Cytoplasmic local changes: vitreous, eosinophilic inclusion bodies etc.
Super-classes obo:TXPO_0000662c

lipidosis dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003516
Super-classes obo:TXPO_0001089c
Sub-classes obo:TXPO_0001876c
obo:TXPO_0002501c
obo:TXPO_0001017c
obo:TXPO_0003738c
obo:TXPO_0003283c
obo:TXPO_0001428c
obo:TXPO_0003792c
obo:TXPO_0001024c
obo:TXPO_0003517c
obo:TXPO_0003287c
obo:TXPO_0001886c
obo:TXPO_0001123c
obo:TXPO_0001108c
obo:TXPO_0001104c
obo:TXPO_0003285c
obo:TXPO_0001394c
obo:TXPO_0001351c
obo:TXPO_0001961c
obo:TXPO_0001301c
obo:TXPO_0001652c
obo:TXPO_0003265c
obo:TXPO_0001875c
obo:TXPO_0001119c
obo:TXPO_0000857c
obo:TXPO_0003812c
obo:TXPO_0001401c
obo:TXPO_0001109c
obo:TXPO_0004925c
obo:TXPO_0001632c
obo:TXPO_0001901c
obo:TXPO_0001884c

APOE (canonical)[Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003517
Super-classes obo:TXPO_0003516c
obo:TXPO_1000006c

acidophilicc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003518
Super-classes obo:PATO_0002070c

Bhlha15(mouse)[Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003519
Super-classes obo:TXPO_0002285c
obo:TXPO_1000045c

metabolic intermediate accumulation [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003520
Super-classes obo:TXPO_0000576c
obo:TXPO_0000889c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000501c
obo:TXPO_0000069op some obo:TXPO_0001193c

power (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003521
Super-classes obo:TXPO_0000305c

ground glass appearance [Liver Pathological Findings] [Ground glass appearance (course)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003522
Super-classes obo:TXPO_0000060c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003542c

eosinophilic granular degeneration [Liver Pathological Findings] [eosinogranular degeneration (course) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003523
Super-classes obo:TXPO_0003501c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c
Sub-classes obo:TXPO_0003536c
obo:TXPO_0003535c
obo:TXPO_0003537c

fatty change [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003524
Description

A metabolic disorder of neutral fat causes fatty change. Lipid droplets consisting of large and small neutral fats (triglycerides) increase in the cytoplasm of hepatocytes. In the case of large lipid droplets, the uneven distribution of nuclei is observed, but in the case of small loose droplets (microvesicular fatty change), uneven distribution of nuclei is not observed. According to the distribution, it classifies into centrilobular, periportal, and diffuse type.
Super-classes obo:TXPO_0001507c
Sub-classes obo:TXPO_0003499c
obo:TXPO_0003525c

vacuolation [Liver Pathological Findings][Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003525
Description

A metabolic disorder of neutral fat causes fatty change. Lipid droplets consisting of large and small neutral fats (triglycerides) increase in the cytoplasm of hepatocytes. In the case of large lipid droplets, the uneven distribution of nuclei is observed, but in the case of small loose droplets (microvesicular fatty change), uneven distribution of nuclei is not observed. According to the distribution, it classifies into centrilobular, periportal, and diffuse type.
Super-classes obo:TXPO_0003524c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0003500op some obo:GO_0005737c

myelin figure in lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003526
Description

The presence of phospholipid inclusions are characterized by the presence of cytoplasmic vacuoles seen under the electron microscope as dense cytoplasmic myelin-like bodies showing a concentric lamellar structure with a periodicity of 4-4.5 nm along with an amorphorous matrix within a single membrane-bound lysosomal space.

Histopathology of preclinical toxicity studies : interpretation and relevance in drug safety studies, Peter Greaves. 4th ed. Amsterdam ; Boston : Elsevier/AP, 2012.
Super-classes obo:TXPO_0001508c
Restrictions obo:TXPO_0003500op some obo:GO_0005764c

moderate accumulation of abnormal proteins in ERc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003527
Super-classes obo:TXPO_0002187c

severe accumulation of abnormal proteins in ERc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003528
Super-classes obo:TXPO_0002187c
Sub-classes obo:TXPO_0000250c

Sgpl1 (mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003529
Super-classes obo:TXPO_0003278c
obo:TXPO_0000014c
Sub-classes obo:TXPO_0003530c
obo:TXPO_0001586c
obo:TXPO_0003262c

Sgpl1 - lipid metabolism regulator (mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003530
Super-classes obo:TXPO_0003529c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:RO_0000087op some obo:TXPO_0002358c

SGPL1 - tumor cell proliferation regulating factor (human) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003531
Super-classes obo:TXPO_0002090c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000087op some obo:TXPO_0003534c

refolding-unfolding imbalance (mild)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003532
Super-classes obo:TXPO_0002459c

refolding-unfolding imbalance (moderate)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003533
Super-classes obo:TXPO_0002459c

regulator of tumor cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003534
Super-classes obo:TXPO_0003159c
Restrictions obo:RO_0002596op some obo:GO_0008283c
Sub-classes obo:TXPO_0002272c
obo:TXPO_0004043c

eosinophilic granular degeneration [Liver Pathological Findings] [eosinogranular degeneration (mild) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003535
Super-classes obo:TXPO_0003523c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

eosinophilic granular degeneration [Liver Pathological Findings] [eosinogranular degeneration (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003536
Super-classes obo:TXPO_0003523c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

eosinophilic granular degeneration [Liver Pathological Findings] [eosinogranular degeneration (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003537
Super-classes obo:TXPO_0003523c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000028c

vacuolation [Liver Pathological Findings][Lipidosis(mild)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003538
Description

A metabolic disorder of neutral fat causes fatty change. Lipid droplets consisting of large and small neutral fats (triglycerides) increase in the cytoplasm of hepatocytes. In the case of large lipid droplets, the uneven distribution of nuclei is observed, but in the case of small loose droplets (microvesicular fatty change), uneven distribution of nuclei is not observed. According to the distribution, it classifies into centrilobular, periportal, and diffuse type.
Super-classes obo:TXPO_0003499c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0003500op some obo:GO_0005737c

phosphatidylcholine effluxc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003539
Super-classes obo:TXPO_0002588c
Restrictions obo:RO_0002234op some obo:CHEBI_64482c
Sub-classes obo:TXPO_0002626c

vacuolation [Liver Pathological Findings][Lipidosis(moderate)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003540
Description

A metabolic disorder of neutral fat causes fatty change. Lipid droplets consisting of large and small neutral fats (triglycerides) increase in the cytoplasm of hepatocytes. In the case of large lipid droplets, the uneven distribution of nuclei is observed, but in the case of small loose droplets (microvesicular fatty change), uneven distribution of nuclei is not observed. According to the distribution, it classifies into centrilobular, periportal, and diffuse type.
Super-classes obo:TXPO_0003499c
Restrictions obo:TXPO_0003500op some obo:GO_0005737c
obo:TXPO_0000774op only obo:TXPO_0000888c

vacuolation [Liver Pathological Findings][Lipidosis(severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003541
Description

A metabolic disorder of neutral fat causes fatty change. Lipid droplets consisting of large and small neutral fats (triglycerides) increase in the cytoplasm of hepatocytes. In the case of large lipid droplets, the uneven distribution of nuclei is observed, but in the case of small loose droplets (microvesicular fatty change), uneven distribution of nuclei is not observed. According to the distribution, it classifies into centrilobular, periportal, and diffuse type.
Super-classes obo:TXPO_0003499c
Restrictions obo:TXPO_0003500op some obo:GO_0005737c
obo:TXPO_0000774op only obo:TXPO_0000888c

ground glass appearance [Liver Pathological Findings] [Ground glass appearance (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003542
Super-classes obo:TXPO_0003522c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

ceramide -apoptosis inducer [Phospholipidosis - positive regulation of apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003543
Super-classes obo:TXPO_0001849c
obo:CHEBI_17761c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c

changing cell survival-cell death balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003544
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0003548c

maintaining cell survival - cell death balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003545
Super-classes obo:TXPO_0000682c
Sub-classes obo:TXPO_0003549c

cell survival-cell death imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003546
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0003547c
obo:TXPO_0003597c
obo:TXPO_0003598c

cell survival-cell death imbalance [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003547
Super-classes obo:TXPO_0003548c
obo:TXPO_0003546c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c

changing cell survival-cell death balance [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003548
Super-classes obo:TXPO_0003544c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0003547c
obo:TXPO_0003549c

maintaining cell survival-cell death balance [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003549
Super-classes obo:TXPO_0003548c
obo:TXPO_0003545c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003356c

GRP78 - tumor cell enhanced survlival factor (canonical)[ER stress - tumor survival]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003550
Super-classes obo:TXPO_0002385c
Restrictions obo:RO_0000087op only obo:TXPO_0003724c

changing cell homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003551
Super-classes obo:TXPO_0001847c
Sub-classes obo:TXPO_0003590c

maintaining cell homeostasisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003552
Super-classes obo:GO_0042592c
Sub-classes obo:TXPO_0003591c

cell homeostasis imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003553
Super-classes obo:TXPO_0000568c
Sub-classes obo:TXPO_0003589c

sequestering of calcium ion [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003554
Super-classes obo:GO_0051208c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

PLA2G1B(mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003555
Super-classes obo:IMR_0000283c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0002260op some obo:IMR_0000283c
Sub-classes obo:TXPO_0000702c

PLA2G2A(mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003556
Super-classes obo:TXPO_0003213c
obo:IMR_0000283c
Restrictions obo:TXPO_0002260op some obo:IMR_0000283c
obo:RO_0000087op some obo:TXPO_0003671c
Sub-classes obo:TXPO_0003557c

PLA2G2A(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003557
Super-classes obo:TXPO_0003556c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:TXPO_0002260op some obo:IMR_0000283c

HMOX1 (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003558
Description

PMID:10330231
Super-classes obo:TXPO_1000196c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003162c
obo:RO_0000086op some obo:TXPO_0000657c

PKIB (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003559
Super-classes obo:TXPO_0001135c
obo:TXPO_0003838c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000005570c
obo:RO_0000087op some obo:TXPO_0002272c

KCNMA1 (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003560
Super-classes obo:TXPO_0003839c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003778c
obo:RO_0000086op some obo:TXPO_0000657c

G-Protein Coupled Receptorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003561
Description

related molecular function GO:0004930
Super-classes obo:TXPO_0000057c

G1/S transition of mitotic cell cyclec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003562
Super-classes obo:TXPO_0003564c
Restrictions obo:RO_0002596op some obo:GO_0044843c
obo:RO_0002598op some obo:GO_0044843c

increased affinityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003563
Super-classes obo:PATO_0002070c

positive regulator of cell cycle phase transition rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003564
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:GO_0044770c
obo:RO_0002598op some obo:GO_0044770c
Sub-classes obo:TXPO_0003562c

forming a complex of CAD and phospholipid (mild)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003565
Super-classes obo:TXPO_0003364c

forming a complex of CAD and phospholipid (moderate)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003566
Super-classes obo:TXPO_0003364c
Sub-classes obo:TXPO_0001260c

forming a complex of CAD and phospholipid (severe)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003567
Super-classes obo:TXPO_0003364c
Sub-classes obo:TXPO_0003365c

cell death [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003568
Super-classes obo:TXPO_0001987c
obo:GO_0008219c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

glutathione depletion [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003569
Super-classes obo:TXPO_0000483c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:TXPO_0000069op some obo:TXPO_0004370c

S1P -apoptosis inhibitor[Phospholipidosis - positive regulation of apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003570
Super-classes obo:TXPO_0001849c
obo:CHEBI_37550c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c

PLA2positively regulator of immune response (canonical) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003571
Super-classes obo:TXPO_0003213c
obo:TXPO_0001804c
Restrictions obo:TXPO_0002260op some obo:IMR_0000283c
obo:RO_0000087op some obo:TXPO_0003572c
obo:RO_0000087op some obo:TXPO_0003671c

positive regulator of immune responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003572
Description

A role played by the entity which positivey regulates the process of infmammatory response.
Super-classes obo:TXPO_0003726c
Restrictions obo:RO_0002598op some obo:TXPO_0000192c

ASPA (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003573
Super-classes obo:TXPO_0003840c
obo:TXPO_0001135c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000000443c

DAB2 (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003574
Description

PMID:19000037
Super-classes obo:TXPO_0003841c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001601c
obo:RO_0000086op some obo:TXPO_0000657c
obo:RO_0000087op some obo:TXPO_0003888c

substance with cytokine rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003575
Description

This entity is inferred from Description Logic.
Super-classes obo:CHEBI_24431c

Insulin resistance (process) [Type II Diabetes]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003576
Super-classes obo:TXPO_0002189c
obo:TXPO_0003342c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003581c
obo:TXPO_0000774op only obo:TXPO_0003042c

insulin absolute deficiencyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003577
Super-classes obo:TXPO_0003289c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003290c
obo:TXPO_0000774op only obo:TXPO_0002033c

negative regulation of phospholipid hydrolysis [Phospholipidosis (latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003578
Super-classes obo:TXPO_0003448c
Restrictions obo:RO_0002212op some obo:TXPO_0003410c
obo:TXPO_0000069op some obo:TXPO_0001908c
obo:TXPO_0000774op only obo:TXPO_0001964c

sphingomyelin biosynthetic process[Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003579
Super-classes obo:GO_0006686c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001468c
obo:TXPO_0000069op some obo:TXPO_0001482c
obo:RO_0002234op some obo:CHEBI_64583c

sphingomyelin biosynthetic process[Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003580
Super-classes obo:GO_0006686c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001816c
obo:RO_0002234op some obo:CHEBI_64583c
obo:TXPO_0000774op only obo:TXPO_0001469c

insulin relative deficiency [diabetes course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003581
Super-classes obo:TXPO_0003289c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003290c
obo:TXPO_0000774op only obo:TXPO_0002033c

CYP4A11(predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003582
Super-classes obo:TXPO_0003836c
obo:TXPO_0001135c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000001579c

hyperfunction of phospholipid degradation (severe)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003583
Super-classes obo:TXPO_0001430c
Sub-classes obo:TXPO_0001431c

increasing phospholipid inflow (severe)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003584
Super-classes obo:TXPO_0001251c

NCR3LG1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003586
Super-classes obo:TXPO_0003842c
obo:TXPO_0001135c

Niemann–Pick disease coursec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003587
Super-classes obo:OGMS_0000063c
Restrictions obo:BFO_0000051op some obo:TXPO_0003635c
obo:TXPO_0003585op some obo:DOID_14504c
Sub-classes obo:TXPO_0001462c
obo:TXPO_0001535c

EIF2A - cell cycle arresr inducer (canonical)[ER stress - translation]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003588
Super-classes obo:TXPO_0001275c
Restrictions obo:RO_0000087op some obo:TXPO_0002270c

cell homeostasis imbalance [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003589
Super-classes obo:TXPO_0003590c
obo:TXPO_0003553c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c

changing cell homeostasis [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003590
Super-classes obo:TXPO_0003551c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0003591c
obo:TXPO_0003589c

maintaining cell homeostasis [Phospholiipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003591
Super-classes obo:TXPO_0003590c
obo:TXPO_0003552c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c

increasing energy [Phospholipidosis(severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003592
Super-classes obo:TXPO_0003593c
obo:TXPO_0000144c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0003594c
obo:BFO_0000051op some obo:TXPO_0004065c

increasing energy [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003593
Super-classes obo:TXPO_0000144c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
Sub-classes obo:TXPO_0004137c
obo:TXPO_0003592c

energy supply [Phospholipidosis(severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003594
Super-classes obo:TXPO_0004077c
obo:TXPO_0003595c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003452c
obo:TXPO_0000069op some obo:TXPO_0002245c
obo:BFO_0000051op some obo:TXPO_0003592c

energy supply [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003595
Super-classes obo:TXPO_0001716c
obo:TXPO_0004077c
Restrictions obo:BFO_0000051op some obo:TXPO_0004137c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0004136c
obo:TXPO_0003594c

increasing number of dead cells in liver [Phosholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003596
Super-classes obo:TXPO_0000341c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003547c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0002276c

cell survival-cell death imbalance [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003597
Super-classes obo:TXPO_0003546c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

maintaining cell survival-cell death balance [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003598
Super-classes obo:TXPO_0003546c
obo:TXPO_0001717c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c

ceramide -phopholipid metabolite [Phospholipidosis - positive regulation of apoptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003599
Super-classes obo:TXPO_0001849c
obo:CHEBI_17761c
Restrictions obo:RO_0000087op some obo:TXPO_0003600c

phospholipid metabolitec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003600
Super-classes obo:CHEBI_25212c

decreasing ceramidec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003601
Super-classes obo:TXPO_0000644c
Sub-classes obo:TXPO_0001569c

ASAH1 (human) - apoptosis inducer [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003602
Super-classes obo:TXPO_0000529c
Restrictions obo:TXPO_0000756op some obo:TXPO_0001442c
obo:RO_0000087op some obo:CHEBI_68495c

mitochondrial damage dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003603
Super-classes obo:TXPO_0002012c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0003360op some obo:NCBITaxon_9606c
Sub-classes obo:TXPO_0003613c
obo:TXPO_0004167c
obo:TXPO_0004318c
obo:TXPO_0003607c
obo:TXPO_0004164c
obo:TXPO_0004614c
obo:TXPO_0004176c
obo:TXPO_0005108c
obo:TXPO_0004170c
obo:TXPO_0004180c
obo:TXPO_0005114c
obo:TXPO_0004232c
obo:TXPO_0004168c
obo:TXPO_0004182c
obo:TXPO_0003605c
obo:TXPO_0004172c
obo:TXPO_0004179c
obo:TXPO_0004220c
obo:TXPO_0005024c
obo:TXPO_0004181c
obo:TXPO_0004238c
obo:TXPO_0004462c
obo:TXPO_0004184c
obo:TXPO_0003611c
obo:TXPO_0005105c
obo:TXPO_0004235c
obo:TXPO_0004319c
obo:TXPO_0004183c
obo:TXPO_0003604c
obo:TXPO_0003610c
obo:TXPO_0003612c
obo:TXPO_0004174c
obo:TXPO_0003614c
obo:TXPO_0005111c
obo:TXPO_0004177c
obo:TXPO_0005117c
obo:TXPO_0004175c
obo:TXPO_0004173c
obo:TXPO_0004619c
obo:TXPO_0004169c
obo:TXPO_0004165c
obo:TXPO_0004178c
obo:TXPO_0004166c
obo:TXPO_0005123c
obo:TXPO_0003608c
obo:TXPO_0004239c
obo:TXPO_0004171c
obo:TXPO_0003606c

PBLD (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003604
Super-classes obo:TXPO_0003603c
obo:TXPO_1000523c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000064081c

CYP3A5 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003605
Super-classes obo:TXPO_1000083c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000001577c

TNFSF10 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003606
Super-classes obo:TXPO_1000541c
obo:TXPO_0003603c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008743c
obo:RO_0000086op some obo:TXPO_0000657c

CXCL6 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003607
Super-classes obo:TXPO_0003603c
obo:TXPO_1000509c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006372c
obo:RO_0000086op some obo:TXPO_0000657c

RAD51AP1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003608
Super-classes obo:TXPO_1000528c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000010635c

oranic anion exportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003609
Super-classes obo:TXPO_0002588c
Sub-classes obo:TXPO_0002632c

CCL2 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003610
Super-classes obo:TXPO_1000086c
obo:TXPO_0003603c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006347c
obo:RO_0000086op some obo:TXPO_0000657c

CDK1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003611
Super-classes obo:TXPO_1000507c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000000983c
Sub-classes obo:TXPO_0004462c

HMMR (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003612
Super-classes obo:TXPO_1000519c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000003161c

GDF15 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003613
Super-classes obo:TXPO_0003603c
obo:TXPO_1000164c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000009518c

DHFR (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003614
Super-classes obo:TXPO_0003603c
obo:TXPO_1000513c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000001719c

severe sphingomyelin accumulation in lysosome of nervous systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003615
Super-classes obo:TXPO_0001691c
Sub-classes obo:TXPO_0001692c

spleen hyperfunction [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003616
Super-classes obo:TXPO_0001361c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c

malfunctioning of hepatic blood circulation [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003617
Super-classes obo:TXPO_0003618c
obo:TXPO_0001718c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003458c
obo:TXPO_0000069op some obo:TXPO_0003457c
obo:TXPO_0000774op only obo:TXPO_0001357c
obo:TXPO_0000069op some obo:TXPO_0003619c

hepatic vascular circulation disorder dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003618
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c
Sub-classes obo:TXPO_0003458c
obo:TXPO_0003457c
obo:TXPO_0003459c
obo:TXPO_0003460c
obo:TXPO_0003617c
obo:TXPO_0003619c
obo:TXPO_0003461c
obo:TXPO_0003463c
obo:TXPO_0003464c
obo:TXPO_0003466c

hepatic shunt formtion [hepatic blood circulatory disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003619
Super-classes obo:TXPO_0003618c
obo:TXPO_0001358c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001357c

inflammatory response [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003620
Super-classes obo:TXPO_0000192c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003621c
obo:BFO_0000051op some obo:TXPO_0001878c
obo:RO_0000057op some obo:TXPO_0001901c
obo:TXPO_0000069op some obo:TXPO_0001890c
obo:BFO_0000051op some obo:TXPO_0001744c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:RO_0000057op some obo:TXPO_0001875c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:BFO_0000051op some obo:TXPO_0000050c

hepatic fibrosis [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003621
Super-classes obo:TXPO_0000816c
obo:TXPO_0001720c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0000888c

inflammatory cell infiltration [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003622
Super-classes obo:TXPO_0001720c
obo:TXPO_0000540c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003620c
obo:TXPO_0000774op only obo:TXPO_0000888c

lipid accumulation in hepatocytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003623
Super-classes obo:GO_0019915c
Restrictions obo:RO_0002233op some obo:CHEBI_18059c
obo:BFO_0000066op only obo:CL_0000182c
Sub-classes obo:TXPO_0001645c
obo:TXPO_0003310c
obo:TXPO_0001129c

lipid accumulation in hepatocyte (mild) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003624
Super-classes obo:TXPO_0001129c
Restrictions obo:BFO_0000051op some obo:TXPO_0001519c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0001873op some obo:TXPO_0003538c

decreased cross-sectional areac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003625
Super-classes obo:PATO_0002058c

cross-sectional areac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003626
Super-classes obo:TXPO_0000310c

balooning [Liver Pathological Findings]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003627
Super-classes obo:TXPO_0001507c
Sub-classes obo:TXPO_0003628c

balooning [Liver Pathological Findings] [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003628
Super-classes obo:TXPO_0003627c
Restrictions obo:TXPO_0003500op some obo:CL_0000182c

hypofunction of peroxisomal fatty acid beta-oxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003629
Super-classes obo:TXPO_0002147c
obo:TXPO_0002007c
Sub-classes obo:TXPO_0001126c

trichloromethyl(.) [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003630
Super-classes obo:CHEBI_30737c
obo:TXPO_0003508c

in vitro (human) 2hrc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003631
Super-classes obo:TXPO_0000795c

toxic course based on fatty changec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003632
Super-classes obo:TXPO_0003763c

Cyp1A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003633
Super-classes obo:TXPO_0001552c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001543c
Sub-classes obo:TXPO_0003805c
obo:TXPO_0004910c

fluid flow ratec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003634
Super-classes obo:PATO_0001574c
Sub-classes obo:PATO_0001838c
obo:PATO_0001839c

mutation [Niemann Pick Disease]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003635
Super-classes obo:TXPO_0003642c
obo:TXPO_0001985c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003587c
Sub-classes obo:TXPO_0001446c

regulation of transmittingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003636
Super-classes obo:TXPO_0000113c
Restrictions obo:RO_0002211op some obo:TXPO_0000442c
Sub-classes obo:GO_0051049c

regulation of bile acid and bile salt transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003637
Super-classes obo:GO_0051049c
Restrictions obo:RO_0002211op some obo:GO_0015721c
Sub-classes obo:TXPO_0002659c

transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003638
Description

related molecular function GO:0005215
Super-classes obo:TXPO_0001393c
Sub-classes obo:TXPO_0003251c
obo:TXPO_0003699c
obo:TXPO_0000154c
obo:TXPO_0003698c
obo:TXPO_0003639c

channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003639
Description

related molecular function GO:0015267
Super-classes obo:TXPO_0003638c
Sub-classes obo:TXPO_0000328c
obo:TXPO_0003696c

phosphholipid binding by phospholipasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003640
Super-classes obo:GO_0005543c
Sub-classes obo:TXPO_0003404c

protein dimerizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003641
Super-classes obo:GO_0051258c
Sub-classes obo:TXPO_0002595c
obo:TXPO_0000712c

Niemann–Pick disease dependent process [diabetes course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003642
Super-classes obo:TXPO_0000808c
Sub-classes obo:TXPO_0003635c

NFKB (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003643
Super-classes obo:TXPO_0003750c
obo:TXPO_1000258c

transcription elongation regulation factorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003644
Description

related molecular function GO:0003711
Super-classes obo:TXPO_0000330c

transcription factorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003645
Description

This term is sometimes used for both gene regulatory proteins as well as the general transcription factors.
Super-classes obo:TXPO_0003715c

acute phase responses by cytokinesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003646
Super-classes obo:GO_0006955c

phospholipid metabolic regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003647
Super-classes obo:TXPO_0002358c
Restrictions obo:RO_0002596op some obo:GO_0006644c
Sub-classes obo:TXPO_0002362c

fatty accid metabolic regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003648
Super-classes obo:TXPO_0004023c
Restrictions obo:RO_0002596op some obo:GO_0006631c
Sub-classes obo:CHEBI_50185c
obo:CHEBI_133190c

STAT1 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003649
Super-classes obo:IMR_0000375c
obo:TXPO_0003750c

gene expression regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003650
Super-classes obo:TXPO_0003230c
Sub-classes obo:TXPO_0002396c

phospholipid metabolism balance [Phospholipidosis (adaptation2)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003651
Super-classes obo:TXPO_0001434c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0001733op some obo:TXPO_0002228c

dysfunction of fatty acid degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003652
Super-classes obo:TXPO_0001741c
Restrictions obo:TXPO_0000716op some obo:GO_0009395c
obo:RO_0002233op some obo:CHEBI_16247c
Sub-classes obo:TXPO_0001739c
obo:TXPO_0001126c

tranquilizing drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003653
Super-classes obo:CHEBI_35488c
Sub-classes obo:TXPO_0003658c

glutathione synthesis regulating agent rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003654
Super-classes obo:TXPO_0004023c
Restrictions obo:RO_0002596op some obo:GO_0006750c
Sub-classes obo:TXPO_0002400c
obo:TXPO_0002394c

potassium channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003655
Description

related molecular function GO:0005267
Super-classes obo:TXPO_0002803c

sodium channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003656
Description

related molecular function GO:0005272
Super-classes obo:TXPO_0002803c

adaptor protein rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003657
Description

General term for proteins in intracellular signaling pathways that link different proteins in the pathway directly together.
Super-classes obo:TXPO_0000564c
Sub-classes obo:TXPO_0003682c
obo:TXPO_0003684c
obo:TXPO_0003681c

antipsychotic agentc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003658
Super-classes obo:TXPO_0003653c
Sub-classes obo:TXPO_0003659c
obo:CHEBI_65191c

first generation antipsychoticc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003659
Super-classes obo:TXPO_0003658c
Sub-classes obo:TXPO_0003661c

enzymec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003660
Description

related molecular function GO:0003824
Super-classes obo:CHEBI_51086c
Sub-classes obo:TXPO_0000519c
obo:TXPO_0000018c
obo:TXPO_0000606c
obo:TXPO_0000565c
obo:TXPO_0000308c
obo:IMR_0000327c
obo:TXPO_0000171c
obo:TXPO_0003663c
obo:TXPO_0003662c

phenothiazine antipsychotic drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003661
Super-classes obo:TXPO_0003659c

helicasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003662
Description

related molecular function: GO:0004386
Super-classes obo:TXPO_0003660c

hydrolasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003663
Description

related molecular function GO:0016787
Super-classes obo:TXPO_0003660c
Sub-classes obo:TXPO_0003668c
obo:TXPO_0003670c
obo:TXPO_0003321c
obo:TXPO_0003673c
obo:IMR_0000304c
obo:TXPO_0002283c
obo:TXPO_0003666c
obo:IMR_0001043c
obo:TXPO_0003664c
obo:TXPO_0001544c
obo:TXPO_0003672c

ATPasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003664
Description

related molecular function GO:0016887
Super-classes obo:TXPO_0003663c

opioid analgesicc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003665
Super-classes obo:CHEBI_35480c

glycosylasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003666
Super-classes obo:TXPO_0003663c
Sub-classes obo:TXPO_0003667c

DNA N-glycosylasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003667
Super-classes obo:TXPO_0003666c

GTPasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003668
Description

related moleular function: GO:0003924
Super-classes obo:TXPO_0003663c
Sub-classes obo:TXPO_0003669c

small GTPasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003669
Super-classes obo:TXPO_0003668c

histone deacetylasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003670
Super-classes obo:TXPO_0003663c

phospholipasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003671
Description

related molecular fuction : GO:0004620
Super-classes obo:TXPO_0002283c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c

phosphoric diester hydrolasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003672
Description

related molecular function GO:0008081
Super-classes obo:TXPO_0003663c
Sub-classes obo:TXPO_0001785c

phosphatasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003673
Description

related molecular function GO:0016791
Super-classes obo:TXPO_0003663c
Sub-classes obo:TXPO_0003675c
obo:TXPO_0003674c

glucose-6-phosphatasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003674
Super-classes obo:TXPO_0003673c

phosphoprotein phosphatasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003675
Description

related molecular function GO:0004721
Super-classes obo:TXPO_0003673c
Sub-classes obo:TXPO_0003679c
obo:TXPO_0003677c
obo:TXPO_0003676c

protein serine/threonine phosphatasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003676
Description

related molecular function GO:0004722
Super-classes obo:TXPO_0003675c

protein serine/threonine/tyrosine phosphatasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003677
Description

Note that this term applies only to free amino acids.
Super-classes obo:TXPO_0003675c

compound accumulation in lysosome [Phospholipidosis (latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003678
Super-classes obo:TXPO_0000930c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004933c
obo:TXPO_0000774op only obo:TXPO_0001964c
obo:RO_0000057op some obo:TXPO_0001560c
obo:RO_0000057op some obo:TXPO_0001425c
obo:BFO_0000051op some obo:TXPO_0002522c
obo:RO_0000057op some obo:TXPO_0000081c
obo:RO_0000057op some obo:TXPO_0001566c

protein tyrosine phosphatasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003679
Description

related molecular function GO:0004725
Super-classes obo:TXPO_0003675c

ligand-gated ion channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003680
Description

related molecular function GO:0015276
Super-classes obo:TXPO_0000328c
Sub-classes obo:TXPO_0002628c

SH2/SH3 adaptor protein rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003681
Description

related molecular function GO:0005070
Super-classes obo:TXPO_0003657c

DD-containing adaptor protein rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003682
Super-classes obo:TXPO_0003657c

size (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003683
Super-classes obo:TXPO_0000305c

docking proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003684
Super-classes obo:TXPO_0003657c

translation initiation factorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003685
Description

related molecular function GO:0003743
Super-classes obo:TXPO_0003730c

lipid mediatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003686
Super-classes obo:CHEBI_33280c

structural constituent of ribosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003687
Description

reated molecular function GO:0003735
Super-classes obo:TXPO_0003691c

adhesion moleculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003688
Description

related molecular function GO:0098631
Super-classes obo:TXPO_0003691c

cytoskeletal proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003689
Description

related molecular function GO:0005200
Super-classes obo:TXPO_0003691c
Sub-classes obo:TXPO_0003690c
obo:TXPO_0000186c
obo:IMR_0000188c

motor proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003690
Description

related molecular function GO:0003774
Super-classes obo:TXPO_0003689c

structural moleculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003691
Super-classes obo:TXPO_0003731c
Sub-classes obo:TXPO_0003695c
obo:TXPO_0003688c
obo:TXPO_0003689c
obo:TXPO_0003687c
obo:TXPO_0003694c

microfilament proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003692
Description

related cellular component GO:0005884
Super-classes obo:TXPO_0003694c

intermediate filament proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003693
Description

related cellular component GO:0005882
Super-classes obo:TXPO_0003694c

cytoskeletal fiber proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003694
Description

related cellular component GO:0099513
Super-classes obo:TXPO_0003691c
Sub-classes obo:TXPO_0003693c
obo:TXPO_0003692c

extracellular matrix structural constituentc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003695
Description

related molecular function GO:0005201
Super-classes obo:TXPO_0003691c

water channelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003696
Description

relate molecular function GO:0015250
Super-classes obo:TXPO_0003639c

amino acid transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003697
Description

related molecular function GO:0015171
Super-classes obo:TXPO_0003698c

transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003698
Description

related molecular function GO:0022857
Super-classes obo:TXPO_0003638c
Sub-classes obo:TXPO_0001307c
obo:TXPO_0003703c
obo:TXPO_0003701c
obo:TXPO_0003702c
obo:TXPO_0000331c
obo:TXPO_0003697c

lipid transportorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003699
Description

related molecular function GO:0005319
Super-classes obo:TXPO_0003638c
Sub-classes obo:TXPO_0003338c
obo:TXPO_0003700c
obo:TXPO_0001451c
obo:TXPO_0001341c

phospholipid transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003700
Description

related molecular function GO:0005548
Super-classes obo:TXPO_0003699c

sugar transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003701
Super-classes obo:TXPO_0003698c
Sub-classes obo:TXPO_0003336c

ion transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003702
Description

related molecular finction GO:0015075
Super-classes obo:TXPO_0003698c
obo:TXPO_0003702c
Sub-classes obo:TXPO_0003702c

bile acid transmembrane transporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003703
Description

related molecular function GO:0015125
Super-classes obo:TXPO_0003698c
Sub-classes obo:TXPO_0000506c
obo:TXPO_0000575c
obo:TXPO_0003704c

bile acid:sodium symporterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003704
Description

related molecular function GO:0008508
Super-classes obo:TXPO_0003703c

role related to changing sizec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003705
Super-classes obo:TXPO_0003708c
Sub-classes obo:TXPO_0002395c

GTP-binding proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003706
Description

re;ated molecular function GO:0005525
Super-classes obo:TXPO_0003709c
Sub-classes obo:TXPO_0003707c

trimeric G-proteinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003707
Super-classes obo:TXPO_0003706c

role related to changing qualityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003708
Super-classes obo:TXPO_0003712c
Sub-classes obo:TXPO_0003705c

role related to assemblingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003709
Super-classes obo:TXPO_0003727c
Sub-classes obo:TXPO_0003706c

regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003710
Super-classes obo:TXPO_0003727c
Sub-classes obo:TXPO_0003230c
obo:TXPO_0003713c
obo:CHEBI_35222c
obo:TXPO_0003822c

molecular inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003711
Super-classes obo:TXPO_0003713c
Sub-classes obo:TXPO_0000876c
obo:CHEBI_23924c
obo:TXPO_0002620c
obo:CHEBI_73240c

changer rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003712
Description

A role played by the entity involved in changing process.
Super-classes obo:TXPO_0003727c
Sub-classes obo:TXPO_0003730c
obo:TXPO_0001316c
obo:TXPO_0000638c
obo:TXPO_0003715c
obo:TXPO_0003997c
obo:TXPO_0003708c
obo:TXPO_0003928c
obo:TXPO_0003731c
obo:TXPO_0000598c
obo:TXPO_0000625c
obo:TXPO_0001561c

molecular (activity) regulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003713
Super-classes obo:TXPO_0003710c
Sub-classes obo:TXPO_0003711c
obo:TXPO_0001147c
obo:TXPO_0003722c
obo:TXPO_0003714c

molecular activatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003714
Super-classes obo:TXPO_0003713c
Sub-classes obo:CHEBI_77731c
obo:TXPO_0003934c
obo:TXPO_0000851c
obo:TXPO_0002374c
obo:TXPO_0001080c

type converterc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003715
Super-classes obo:TXPO_0003712c
Sub-classes obo:TXPO_0003645c

transcription coregulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003716
Description

related molecular function GO:0003712
Super-classes obo:TXPO_0000330c
Sub-classes obo:TXPO_0003717c

transcriptional co-activatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003717
Description

related molecular function GO:0003713
Super-classes obo:TXPO_0003716c

lysosomal processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003718
Super-classes obo:TXPO_0000538c

mitochondrial procressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003719
Super-classes obo:TXPO_0000538c

pathway regulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003720
Super-classes obo:TXPO_0003230c
Sub-classes obo:CHEBI_76932c

negative regulator of Wnt signaling pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003721
Super-classes obo:CHEBI_76932c

enzyme regulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003722
Super-classes obo:TXPO_0003713c

molecular carrierc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003723
Super-classes obo:TXPO_0001393c
Sub-classes obo:TXPO_0000885c

positive regulator of tumorigenesis rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003724
Super-classes obo:TXPO_0003230c

regulator of tumor cell activity rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003725
Super-classes obo:TXPO_0003230c
Sub-classes obo:TXPO_0000759c
obo:TXPO_0000329c

regulator of immune responsec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003726
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002596op some obo:TXPO_0000192c
Sub-classes obo:TXPO_0002289c
obo:TXPO_0003572c

functional rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003727
Super-classes obo:BFO_0000023c
Sub-classes obo:TXPO_0003709c
obo:TXPO_0003710c
obo:TXPO_0003732c
obo:TXPO_0003712c
obo:TXPO_0003728c
obo:TXPO_0001393c

role related to receivingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003728
Super-classes obo:TXPO_0003727c
Sub-classes obo:TXPO_0000320c
obo:TXPO_0000882c
obo:TXPO_0002463c

hardness (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003729
Super-classes obo:TXPO_0000305c

changing state rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003730
Super-classes obo:TXPO_0003712c
Sub-classes obo:TXPO_0003685c
obo:TXPO_0000668c

keeping structure rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003731
Super-classes obo:TXPO_0003712c
Sub-classes obo:TXPO_0003691c

molecular (activity) co-regulatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003732
Super-classes obo:TXPO_0003727c
Sub-classes obo:TXPO_0002922c
obo:CHEBI_23357c

keeping structurec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003733
Super-classes obo:TXPO_0002566c
Sub-classes obo:TXPO_0000197c
obo:TXPO_0002236c

GRP94 - tumor cell enhanced survlival factor (canonical)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003734
Super-classes obo:TXPO_0002410c
Restrictions obo:RO_0000087op only obo:TXPO_0003724c

HSP90B1 - tumor cell production promoting factor (human)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003735
Super-classes obo:TXPO_0000802c
Restrictions obo:RO_0000087op only obo:TXPO_0003724c

ER stress dependent process (molecular level)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003736
Super-classes obo:TXPO_0001717c
Sub-classes obo:TXPO_0003075c
obo:TXPO_0000055c
obo:TXPO_0002953c
obo:TXPO_0000730c
obo:TXPO_0002940c
obo:TXPO_0002957c
obo:TXPO_0000710c
obo:TXPO_0002798c
obo:TXPO_0000721c
obo:TXPO_0002951c
obo:TXPO_0002762c
obo:TXPO_0002926c
obo:TXPO_0002710c
obo:TXPO_0002176c
obo:TXPO_0003081c
obo:TXPO_0002213c
obo:TXPO_0002887c
obo:TXPO_0000674c
obo:TXPO_0002918c
obo:TXPO_0003043c
obo:TXPO_0003103c
obo:TXPO_0002827c
obo:TXPO_0002571c
obo:TXPO_0002977c
obo:TXPO_0002690c
obo:TXPO_0002447c
obo:TXPO_0002598c
obo:TXPO_0003094c
obo:TXPO_0000707c
obo:TXPO_0002103c
obo:TXPO_0003113c
obo:TXPO_0003030c
obo:TXPO_0002684c
obo:TXPO_0002872c
obo:TXPO_0002596c
obo:TXPO_0002924c
obo:TXPO_0000416c
obo:TXPO_0002467c
obo:TXPO_0003096c
obo:TXPO_0002976c
obo:TXPO_0003074c
obo:TXPO_0001306c
obo:TXPO_0000708c
obo:TXPO_0000349c
obo:TXPO_0001905c
obo:TXPO_0000726c
obo:TXPO_0002393c
obo:TXPO_0003091c
obo:TXPO_0003080c
obo:TXPO_0003093c
obo:TXPO_0002378c
obo:TXPO_0002841c
obo:TXPO_0002988c
obo:TXPO_0003079c
obo:TXPO_0002752c
obo:TXPO_0002738c
obo:TXPO_0002466c
obo:TXPO_0000709c
obo:TXPO_0000700c
obo:TXPO_0000697c
obo:TXPO_0002911c
obo:TXPO_0003045c
obo:TXPO_0000049c
obo:TXPO_0003109c
obo:TXPO_0000358c
obo:TXPO_0003107c
obo:TXPO_0003104c
obo:TXPO_0000698c
obo:TXPO_0000713c
obo:TXPO_0000445c
obo:TXPO_0003068c
obo:TXPO_0003097c
obo:TXPO_0003092c
obo:TXPO_0003078c
obo:TXPO_0002807c
obo:TXPO_0002546c
obo:TXPO_0002760c
obo:TXPO_0003064c
obo:TXPO_0002833c
obo:TXPO_0000719c

apoptosome assembly [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003737
Super-classes obo:GO_0097314c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000446c

AP1M2 (canonical)[Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003738
Description

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Super-classes obo:TXPO_1000003c
obo:TXPO_0003516c
Restrictions obo:RO_0000087op some obo:TXPO_0003638c

leaking content from cell [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003739
Super-classes obo:TXPO_0000526c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003740c
obo:TXPO_0000774op only obo:TXPO_0001277c

inflammatory cell infiltration [Cholestasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003740
Super-classes obo:TXPO_0000540c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002670c
obo:TXPO_0000774op only obo:TXPO_0001277c

increasing organelle volumec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003741
Super-classes obo:TXPO_0000139c
Restrictions obo:RO_0002234op some (obo:GO_0043226c and ub744bL93621C17c)
Sub-classes obo:TXPO_0000143c
obo:TXPO_0000218c

hepatic fibrosis dependent processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003742
Super-classes obo:TXPO_0001715c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
Sub-classes obo:TXPO_0003782c
obo:TXPO_0001467c
obo:TXPO_0001289c
obo:TXPO_0000224c
obo:TXPO_0003746c
obo:TXPO_0003786c
obo:TXPO_0001305c
obo:TXPO_0003800c
obo:TXPO_0001288c
obo:TXPO_0003757c
obo:TXPO_0001268c
obo:TXPO_0003783c
obo:TXPO_0001387c
obo:TXPO_0001721c
obo:TXPO_0001265c
obo:TXPO_0002152c
obo:TXPO_0001310c
obo:TXPO_0003759c
obo:TXPO_0003802c
obo:TXPO_0003745c
obo:TXPO_0001419c
obo:TXPO_0003743c
obo:TXPO_0001408c
obo:TXPO_0003761c
obo:TXPO_0003755c
obo:TXPO_0003781c
obo:TXPO_0003779c
obo:TXPO_0000503c
obo:TXPO_0001389c

kupffer cell activation [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003743
Super-classes obo:TXPO_0003184c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0003745c

permeability (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003744
Super-classes obo:TXPO_0000305c

cytokine secretion [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003745
Super-classes obo:GO_0050663c
obo:TXPO_0003742c
Restrictions obo:TXPO_0001868op some obo:CL_0000091c
obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0003755c
obo:RO_0002234op some obo:TXPO_0003751c
obo:RO_0002234op some obo:TXPO_0003752c
obo:TXPO_0000069op some obo:TXPO_0003746c

hepatic stellate cell activation [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003746
Super-classes obo:GO_0035733c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003757c
obo:TXPO_0000069op some obo:TXPO_0000224c
obo:TXPO_0000774op only obo:TXPO_0002329c

fluid flow rate (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003747
Super-classes obo:PATO_0001574c

CCL4 [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003748
Super-classes obo:TXPO_0003509c

hepatic fibrosis dependent chemical entityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003749
Super-classes obo:TXPO_0001731c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
Sub-classes obo:TXPO_0000029c
obo:TXPO_0003771c
obo:TXPO_0003750c

hepatic fibrosis dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003750
Super-classes obo:TXPO_0003749c
Sub-classes obo:TXPO_0003768c
obo:TXPO_0003767c
obo:TXPO_0003774c
obo:TXPO_0003775c
obo:TXPO_0003777c
obo:TXPO_0003778c
obo:TXPO_0003649c
obo:TXPO_0003643c
obo:TXPO_0003785c
obo:TXPO_0003752c
obo:TXPO_0003776c
obo:TXPO_0003062c
obo:TXPO_0003773c
obo:TXPO_0003751c

TGFB1 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003751
Super-classes obo:IMR_0000042c
obo:TXPO_1000371c
obo:TXPO_0003750c
Restrictions obo:TXPO_0002260op some obo:IMR_0000041c

PDGF (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003752
Super-classes obo:TXPO_0003750c
obo:IMR_0000032c
obo:TXPO_1000275c
Restrictions obo:TXPO_0002260op some obo:IMR_0000032c

counting qualityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003753
Super-classes obo:BFO_0000019c
Sub-classes obo:TXPO_0003758c
obo:PATO_0002002c

addition of xenobioticsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003754
Super-classes obo:TXPO_0000166c

hepatic stellate cell proliferation [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003755
Super-classes obo:GO_1990922c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c

Increasing drug metabolite [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003756
Super-classes obo:TXPO_0001720c
obo:TXPO_0002364c
Restrictions obo:BFO_0000051op some obo:TXPO_0003787c
obo:TXPO_0000069op some obo:TXPO_0001882c
obo:TXPO_0000774op only obo:TXPO_0000888c

myoblast differentiation [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003757
Super-classes obo:GO_0045445c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0003759c
obo:TXPO_0000069op some obo:TXPO_0003761c

decreased number (quality)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003758
Super-classes obo:TXPO_0003753c

extracellular structure organization [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003759
Super-classes obo:GO_0030198c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003800c
obo:TXPO_0000774op only obo:TXPO_0002329c

LEAP2 (human)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003760
Description

Liver Enriched Antimicrobial Peptide 2
Super-classes obo:TXPO_1000221c
obo:TXPO_0000029c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

negative regulation of extracellular matrix disassembly [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003761
Super-classes obo:TXPO_0003742c
obo:GO_0010716c
Restrictions obo:BFO_0000051op some obo:TXPO_0001721c
obo:TXPO_0000774op only obo:TXPO_0002329c
obo:BFO_0000051op some obo:TXPO_0002152c

HMGA1 (human)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003762
Description

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
Super-classes obo:TXPO_0000029c
obo:TXPO_1000187c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

toxic course based on pathological findingsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003763
Super-classes (obo:TXPO_0000608c and ub744bL93911C13c)
obo:TXPO_0000608c
Sub-classes obo:TXPO_0003764c
obo:TXPO_0003765c
obo:TXPO_0003632c

toxic course based on the eosinogranular degeneration (finding)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003764
Super-classes obo:TXPO_0003763c

toxic course based on ground glass appearancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003765
Super-classes obo:TXPO_0003763c

CERB processingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003766
Super-classes obo:GO_0016485c
Sub-classes obo:TXPO_0003079c

ET-1 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003767
Super-classes obo:TXPO_0003750c
obo:TXPO_1000128c

CCL2 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003768
Super-classes obo:TXPO_1000086c
obo:TXPO_0003750c

acetaldehyde [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003769
Super-classes obo:CHEBI_15343c
obo:TXPO_0003771c

cytoplasm protein quality control by the ubiquitin-proteasome systemc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003770
Description

See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Super-classes obo:GO_0043161c

hepatic fibrosis dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003771
Super-classes obo:TXPO_0003749c
Sub-classes obo:TXPO_0003772c
obo:TXPO_0003769c

CCL4 [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003772
Super-classes obo:CHEBI_27385c
obo:TXPO_0003771c

MMP9 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003773
Super-classes obo:TXPO_1000239c
obo:TXPO_0003750c

IL-1 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003774
Super-classes obo:IMR_0000011c
obo:TXPO_0003750c

IL-6 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003775
Super-classes obo:TXPO_0003750c
obo:IMR_0000010c

TNFΑ (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003776
Super-classes obo:TXPO_0003750c
obo:TXPO_1000374c

MMP2 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003777
Super-classes obo:TXPO_1000238c
obo:TXPO_0003750c

CXCR3 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003778
Super-classes obo:TXPO_1000077c
obo:TXPO_0003750c

necrosis [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003779
Super-classes obo:GO_0070265c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c
obo:TXPO_0000069op some obo:TXPO_0003743c

CCL3 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003780
Super-classes obo:TXPO_0000019c
Sub-classes obo:TXPO_0003787c

decreasing blood flow [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003781
Super-classes obo:TXPO_0000359c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003779c

scarring [fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003782
Super-classes obo:TXPO_0003742c
obo:TXPO_0000681c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c

nodule formation [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003783
Super-classes obo:TXPO_0000612c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c

TIMP2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003784
Super-classes obo:TXPO_1000431c
Sub-classes obo:TXPO_0003785c

TIMP2 (canonical)[Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003785
Super-classes obo:TXPO_0003750c
obo:TXPO_0003784c

negative regulation of apoptotic process [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003786
Super-classes obo:TXPO_0003742c
obo:GO_0043066c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002329c

CCL3 production [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003787
Super-classes obo:TXPO_0003780c
obo:TXPO_0001720c
Restrictions obo:RO_0002233op some obo:TXPO_0003748c
obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0000057op some obo:TXPO_0003792c
obo:TXPO_0000069op some obo:TXPO_0001882c
obo:RO_0002234op some obo:TXPO_0003630c

CTSB (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003788
Super-classes obo:TXPO_0001135c
obo:TXPO_0003843c
Restrictions obo:TXPO_0000043op some obo:GO_0005764c
obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000001508c

decreasing stored glycogenc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003789
Super-classes obo:TXPO_0002050c

negative regulation of gap junction assembly [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003790
Super-classes obo:GO_1903597c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003793c
obo:TXPO_0001868op some obo:TXPO_0001524c

CAR (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003791
Super-classes obo:TXPO_0003862c
obo:TXPO_0000472c
Restrictions obo:RO_0000087op some obo:TXPO_0003863c
Sub-classes obo:TXPO_0003930c
obo:TXPO_0004102c
obo:TXPO_0003977c
obo:TXPO_0001543c

CYP2E1 (canonical)[Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003792
Super-classes obo:TXPO_1000081c
obo:TXPO_0003516c

cell division [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003793
Super-classes obo:TXPO_0001728c
obo:GO_0051301c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001030c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000961c

negative regulation of mRNA degradationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003794
Super-classes obo:TXPO_0000126c

positive regulation of cell division [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003795
Super-classes obo:TXPO_0001728c
obo:GO_0051781c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of adherens junction assembly [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003796
Super-classes obo:TXPO_0003813c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001582c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0001868op some obo:TXPO_0001524c

changing cycle phasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003797
Super-classes obo:TXPO_0000415c
Restrictions obo:TXPO_0000531op some obo:PATO_0000083c
Sub-classes obo:TXPO_0003798c

maintaining cyclicityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003798
Super-classes obo:TXPO_0003797c
Sub-classes obo:GO_0007050c

Cytochrome P450 activation [NASH]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003799
Super-classes obo:TXPO_0001720c
obo:TXPO_0001758c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001856c
obo:TXPO_0000069op some obo:TXPO_0003787c
obo:RO_0000057op some obo:TXPO_0003792c
obo:TXPO_0000774op only obo:TXPO_0001155c

extracellular matrix production- degradation imbalance [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003800
Super-classes obo:TXPO_0003742c
obo:TXPO_0003801c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003802c
obo:TXPO_0000774op only obo:TXPO_0002329c

extracellular matrix production- degradation imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003801
Super-classes obo:TXPO_0000567c
Sub-classes obo:TXPO_0003800c

hepatic fibrosis [Fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003802
Super-classes obo:TXPO_0000816c
obo:TXPO_0003742c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003782c
obo:BFO_0000051op some obo:TXPO_0003783c
obo:TXPO_0000774op only obo:TXPO_0002329c

hepatic fibrosis by alcoholic liver injuryc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003803
Description

under construction
Super-classes obo:TXPO_0002329c
Restrictions obo:BFO_0000051op some obo:TXPO_0001289c
obo:BFO_0000051op some obo:TXPO_0001288c
obo:BFO_0000051op some obo:TXPO_0001305c
obo:BFO_0000051op some obo:TXPO_0001268c
obo:BFO_0000051op some obo:TXPO_0001310c
obo:BFO_0000051op some obo:TXPO_0000503c
obo:BFO_0000051op some obo:TXPO_0001387c

hepatic fibrosis by NASHc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003804
Description

under construction
Super-classes obo:TXPO_0002329c

CYP1A2(canonical) [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003805
Super-classes obo:TXPO_0002045c
obo:TXPO_0003633c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001544c

overeating [NAFLD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003806
Super-classes obo:TXPO_0001541c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003810c
obo:TXPO_0000069op some obo:TXPO_0003809c
obo:TXPO_0000774op only obo:TXPO_0003498c
obo:TXPO_0000069op some obo:TXPO_0003811c

increasing fatty acid synthesis substrate [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003807
Super-classes obo:TXPO_0001720c
obo:TXPO_0000284c
Restrictions obo:BFO_0000051op some obo:TXPO_0003808c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0000069op some obo:TXPO_0000890c
obo:BFO_0000051op some obo:TXPO_0003809c

converting to acetyl CoA [NAFLD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003808
Super-classes obo:TXPO_0001720c
obo:TXPO_0000283c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003807c
obo:TXPO_0000774op only obo:TXPO_0000888c

increasing amount of carbohydrate [NAFLD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003809
Super-classes obo:TXPO_0001720c
obo:TXPO_0000267c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003808c

increase in lipid inflow into hepatocyte [NAFLD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003810
Super-classes obo:TXPO_0003494c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003498c
obo:BFO_0000051op some obo:TXPO_0003811c

increaing in fatty acid inflow into hepatocyte [NAFLD]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003811
Super-classes obo:TXPO_0000892c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003494c
obo:TXPO_0000774op only obo:TXPO_0003498c

SREBP1C (canonical)[Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003812
Super-classes obo:TXPO_0003516c
obo:TXPO_0003966c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

negative regulation of adherens junction assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003813
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0034333c
Sub-classes obo:TXPO_0004845c
obo:TXPO_0003796c

signal rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003814
Super-classes obo:TXPO_0001393c
Sub-classes obo:TXPO_0003816c

molecular assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003815
Super-classes obo:TXPO_0000468c
Restrictions obo:TXPO_0000531op some obo:PATO_0001629c
obo:RO_0002233op some obo:CHEBI_23367c
Sub-classes obo:TXPO_0002661c
obo:GO_0065003c

stress signal rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003816
Super-classes obo:TXPO_0003814c

ITGB3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003817
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003690c
Sub-classes obo:TXPO_0000077c
obo:TXPO_0004086c

tunicamycin - apoptosis inducer [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003818
Super-classes obo:CHEBI_29699c
obo:TXPO_0003012c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000087op some obo:CHEBI_68495c

tunicamycin - lipidosis inducer [ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003819
Super-classes obo:CHEBI_29699c
obo:TXPO_0003012c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0000087op some obo:TXPO_0003822c

lipofuscin granulec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003820
Super-classes obo:GO_0048770c

melanin granulec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003821
Super-classes obo:GO_0048770c

steatosis inducer rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003822
Super-classes obo:TXPO_0003710c

CREB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003823
Super-classes obo:CHEBI_25367c

lysosomal cholesterol storage (severe)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003824
Super-classes obo:TXPO_0000694c
obo:TXPO_0001537c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003435c
obo:TXPO_0000069op some obo:TXPO_0002094c
obo:TXPO_0000774op only obo:TXPO_0002215c

Inflammasome activation [pyroptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003825
Super-classes obo:TXPO_0001727c
obo:TXPO_0001107c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003827c
obo:TXPO_0000774op only obo:TXPO_0000326c
obo:RO_0000057op some obo:TXPO_0003826c

CASP1 (canonical)[pyroptopsis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003826
Super-classes obo:IMR_0100302c
obo:TXPO_0003195c

Inflammatory cytokine gene expression[pyroptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003827
Super-classes obo:TXPO_0001727c
obo:TXPO_0002266c
Restrictions obo:RO_0000057op some obo:TXPO_0003828c
obo:TXPO_0000774op only obo:TXPO_0000326c

IL-1B (canonical)[pyroptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003828
Super-classes obo:TXPO_0003195c
obo:TXPO_1000200c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

compound accumulation in liver [Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003829
Super-classes obo:TXPO_0002325c
obo:TXPO_0001727c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000008c
obo:TXPO_0000774op only obo:TXPO_0000323c

inflammatory response [pyroptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003830
Super-classes obo:TXPO_0001727c
obo:TXPO_0000192c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002144c
obo:RO_0000057op some obo:TXPO_0003828c
obo:TXPO_0000774op only obo:TXPO_0000326c
obo:BFO_0000051op some obo:TXPO_0003827c
obo:RO_0000057op some obo:TXPO_0003826c
obo:BFO_0000051op some obo:TXPO_0003825c

inflammatory cell infiltration [pyroptosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003831
Super-classes obo:TXPO_0001727c
obo:TXPO_0000540c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000326c
obo:TXPO_0000069op some obo:TXPO_0003830c

SULT1C2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003832
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006819c
Sub-classes obo:TXPO_0000078c
obo:TXPO_0004118c

MMAA (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003833
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000166785c
Sub-classes obo:TXPO_0000659c
obo:TXPO_0004095c

SPON2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003834
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010417c
Sub-classes obo:TXPO_0000188c
obo:TXPO_0004112c
obo:TXPO_0001789c

RSAD2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003835
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000091543c
Sub-classes obo:TXPO_0004108c
obo:TXPO_0001903c

CYP4A11 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003836
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001579c
Sub-classes obo:TXPO_0003582c
obo:TXPO_0001859c

FNIP2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003837
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000057600c
Sub-classes obo:TXPO_0002579c
obo:TXPO_0003894c
obo:TXPO_0004018c

PKIB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003838
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005570c
Sub-classes obo:TXPO_0003559c
obo:TXPO_0004106c

KCNMA1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003839
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003778c
Sub-classes obo:TXPO_0004092c
obo:TXPO_0004087c
obo:TXPO_0003560c

ASPA (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003840
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000443c
Sub-classes obo:TXPO_0004149c
obo:TXPO_0003573c

DAB2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003841
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001601c
Sub-classes obo:TXPO_0003574c
obo:TXPO_0003916c
obo:TXPO_0003900c

NCR3LG1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003842
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000374383c
Sub-classes obo:TXPO_0003586c
obo:TXPO_0004105c

CTSB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003843
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c
Sub-classes obo:TXPO_0003996c
obo:TXPO_0003941c
obo:TXPO_0003788c

hyperfunction of phenobarbital metabolism phase I by Cytochrome P450 (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003844
Super-classes obo:TXPO_0003864c
Restrictions obo:BFO_0000051op some obo:TXPO_0001627c
obo:BFO_0000051op some obo:TXPO_0000967c
obo:TXPO_0000069op some obo:TXPO_0003850c
obo:TXPO_0000069op some obo:TXPO_0003848c
obo:TXPO_0000069op some obo:TXPO_0001677c

smooth endoplasmic reticulum membrane organization (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003845
Super-classes obo:TXPO_0001613c
obo:TXPO_0001615c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0001677c

hyperfunction of drug metabolism phase I (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003846
Super-classes obo:TXPO_0000938c
Restrictions obo:RO_0000057op some obo:TXPO_0000990c
obo:BFO_0000066op some obo:GO_0005790c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000943c
obo:RO_0000057op some obo:TXPO_0000991c
Sub-classes obo:TXPO_0001629c

hyperfunction of decreasing the amount of phenobarbital (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003847
Super-classes obo:TXPO_0001654c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001647c
obo:TXPO_0000069op some obo:TXPO_0003856c
obo:BFO_0000051op some obo:TXPO_0003844c
obo:BFO_0000051op some obo:TXPO_0003848c
obo:TXPO_0000774op only obo:TXPO_0001432c

hyperfunction of glucuronic acid conjugation for phenobarbital intermediate metabolite (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003848
Super-classes obo:TXPO_0001663c
obo:TXPO_0001227c
Restrictions obo:RO_0000057op some obo:TXPO_0000992c
obo:TXPO_0000774op only obo:TXPO_0001432c

hyperfunction of drug metabolism phase II (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003849
Super-classes obo:TXPO_0000943c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

reactive oxygen species biosynthetic process (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003850
Super-classes obo:TXPO_0000948c
obo:GO_1903409c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003851c
obo:TXPO_0000774op only obo:TXPO_0001432c

mitochondrial dysfunction [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003851
Super-classes obo:TXPO_0001728c
obo:TXPO_0002361c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003852c

necrosis [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003852
Super-classes obo:GO_0070265c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001031c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0001582c

glycogen catabolic process (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003853
Super-classes obo:TXPO_0000958c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001797c
obo:TXPO_0000774op only obo:TXPO_0001432c

making existence of drugc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003854
Super-classes obo:TXPO_0001851c

nuclear receptor activation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003855
Super-classes obo:TXPO_0001728c
obo:TXPO_0000158c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000937c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0000935c
obo:TXPO_0000988c

phenobarbital metabolism imbalance [Ground glass appearance (severe) - tumorigenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003856
Super-classes obo:TXPO_0003860c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0001675c

ground glass appearance with Cytochrome P450 activation [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003857
Super-classes obo:TXPO_0001432c
Restrictions obo:BFO_0000051op some obo:TXPO_0003901c
obo:BFO_0000051op some obo:TXPO_0001026c
obo:BFO_0000051op some obo:TXPO_0001621c
obo:BFO_0000051op some obo:TXPO_0000781c
obo:BFO_0000051op some obo:TXPO_0000981c
obo:BFO_0000051op some obo:TXPO_0003902c
obo:TXPO_0000004op some obo:TXPO_0001621c
obo:BFO_0000051op some obo:TXPO_0000948c
obo:BFO_0000051op some obo:TXPO_0000982c
Sub-classes obo:TXPO_0001588c

hyperfunction of cytochrome p450 gene expression by phenobarbital [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003858
Description

CAR activator phenobarbital can induce CYP2B10 and CYP3A11 in wild type and PXR knock-out mouse.
Super-classes obo:TXPO_0000937c
obo:TXPO_0002051c
Restrictions obo:TXPO_0001868op some obo:TXPO_0001524c
obo:TXPO_0000069op some obo:TXPO_0003864c
obo:RO_0002234op some obo:TXPO_0000990c
obo:RO_0002234op some obo:TXPO_0003907c
obo:RO_0002234op some obo:TXPO_0003909c
obo:RO_0002234op some obo:TXPO_0000979c
obo:RO_0002234op some obo:TXPO_0003908c
Sub-classes obo:TXPO_0003874c
obo:TXPO_0001627c

hyperfunction of decreasing the amount of drugs [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003859
Super-classes obo:TXPO_0001728c
obo:TXPO_0001834c
Restrictions obo:TXPO_0001502op some obo:TXPO_0001647c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0000443c
Sub-classes obo:TXPO_0001836c
obo:TXPO_0003861c

phenobarbital metabolism imbalance [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003860
Super-classes obo:TXPO_0001665c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000934c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003869c
obo:TXPO_0003856c

hyperfunction of decreasing the amount of drugs by Cytochrome P450 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003861
Super-classes obo:TXPO_0003859c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0001654c

CAR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003862
Super-classes obo:TXPO_0001509c
Sub-classes obo:TXPO_0003791c
obo:TXPO_0005071c
obo:TXPO_0002724c

xenosensorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003863
Super-classes obo:TXPO_0000882c

hyperfunction of phenobarbital metabolism phase I by Cytochrome P450 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003864
Super-classes obo:TXPO_0001621c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003903c
obo:BFO_0000051op some obo:TXPO_0003858c
obo:BFO_0000051op some obo:TXPO_0002309c
obo:TXPO_0000069op some obo:TXPO_0001663c
Sub-classes obo:TXPO_0003844c
obo:TXPO_0003873c

regulation of generation of precursor metabolites and energy (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003865
Super-classes obo:TXPO_0003953c
Restrictions obo:BFO_0000051op some obo:TXPO_0003925c
obo:TXPO_0000069op some obo:TXPO_0001677c
obo:BFO_0000051op some obo:TXPO_0003952c

phenobarbital induced liver tumor via ground glass appearancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003866
Super-classes obo:TXPO_0001588c
Restrictions obo:BFO_0000051op some obo:TXPO_0000978c
obo:BFO_0000051op some obo:TXPO_0001031c
obo:BFO_0000051op some obo:TXPO_0000954c
obo:BFO_0000051op some obo:TXPO_0000977c
obo:BFO_0000051op some obo:TXPO_0000962c
obo:BFO_0000051op some obo:TXPO_0002322c
obo:BFO_0000051op some obo:TXPO_0003796c
obo:BFO_0000051op some obo:TXPO_0003850c
obo:BFO_0000051op some obo:TXPO_0001582c
obo:BFO_0000051op some obo:TXPO_0003844c
obo:BFO_0000051op some obo:TXPO_0001675c
obo:BFO_0000051op some obo:TXPO_0001013c
obo:BFO_0000051op some obo:TXPO_0003865c
obo:BFO_0000051op some obo:TXPO_0001030c
obo:BFO_0000051op some obo:TXPO_0003848c
obo:BFO_0000051op some obo:TXPO_0003597c
obo:TXPO_0000004op some obo:TXPO_0003844c
obo:BFO_0000051op some obo:TXPO_0000669c
obo:BFO_0000051op some obo:TXPO_0001028c
obo:BFO_0000051op some obo:TXPO_0003852c
obo:BFO_0000051op some obo:TXPO_0002323c
obo:BFO_0000051op some obo:TXPO_0000314c
obo:BFO_0000051op some obo:TXPO_0000959c
obo:BFO_0000051op some obo:TXPO_0003979c
obo:BFO_0000051op some obo:TXPO_0000952c
obo:BFO_0000051op some obo:TXPO_0000947c
obo:BFO_0000051op some obo:TXPO_0001033c
obo:BFO_0000051op some obo:TXPO_0001677c
obo:BFO_0000051op some obo:TXPO_0003856c
obo:BFO_0000051op some obo:TXPO_0003845c
obo:BFO_0000051op some obo:TXPO_0002320c
obo:BFO_0000051op some obo:TXPO_0003851c
obo:BFO_0000051op some obo:TXPO_0000597c
obo:BFO_0000051op some obo:TXPO_0002319c

clonal expansion of preneoplastic cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003867
Super-classes obo:NCIT_C20613c
Sub-classes obo:TXPO_0003904c

hyperfunction of increasing the amount of phenobarbital [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003868
Super-classes obo:TXPO_0001840c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003869c
obo:TXPO_0000716op some obo:TXPO_0001637c

phenobarbital metabolism imbalance [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003869
Super-classes obo:TXPO_0003860c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003870c
obo:TXPO_0000774op only obo:TXPO_0001432c

phenobarbital accumulation in liver [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003870
Super-classes obo:TXPO_0000934c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

hyperfunction of decreasing the amount of phenobarbital [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003871
Super-classes obo:TXPO_0001654c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0003872c
obo:TXPO_0000069op some obo:TXPO_0003869c
obo:TXPO_0000716op some obo:TXPO_0001647c
obo:BFO_0000051op some obo:TXPO_0003873c

hyperfunction of glucuronic acid conjugation for phenobarbital intermediate metabolite [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003872
Super-classes obo:TXPO_0001663c
obo:TXPO_0001227c
Restrictions obo:RO_0000057op some obo:TXPO_0000992c
obo:TXPO_0000774op only obo:TXPO_0001432c

hyperfunction of phenobarbital metabolism phase I by Cytochrome P450 [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003873
Super-classes obo:TXPO_0003864c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0003874c
obo:TXPO_0000069op some obo:TXPO_0003872c
obo:BFO_0000051op some obo:TXPO_0003875c

hyperfunction of cytochrome p450 gene expression  by phenobarbital [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003874
Super-classes obo:TXPO_0003858c
obo:TXPO_0002051c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003873c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0003875c

constitutive androstane receptor activation by phenobarbital (moderate) [Ground glass appearance ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003875
Super-classes obo:TXPO_0002309c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003874c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0001868op some obo:TXPO_0001524c

hyperfunction of moving phenobarbital to the inside of liver [Ground glass appearance (moderate) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003876
Super-classes obo:TXPO_0002719c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000716op some obo:TXPO_0001719c
obo:TXPO_0000069op some obo:TXPO_0003868c

positive regulation of autophagy [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003877
Super-classes obo:TXPO_0001716c
obo:GO_0010508c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0000057op some obo:TXPO_0004000c
obo:RO_0000057op some obo:TXPO_0003878c
obo:TXPO_0000069op some obo:TXPO_0003889c
obo:TXPO_0000069op some obo:TXPO_0001497c
obo:RO_0000057op some obo:TXPO_0003788c

CTSB- autophagy inducing factor (human)[Phospholipidosis - autophagy indution]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003878
Super-classes obo:TXPO_0003941c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c
obo:RO_0000087op some obo:TXPO_0000487c

CTSB- tumor cell metastasis factor (human)[Phospholipidosis - tumor metasitasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003879
Super-classes obo:TXPO_0003941c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c
obo:RO_0000087op some obo:TXPO_0003880c

tumor metastasis inducerc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003880
Super-classes obo:TXPO_0003230c

CYP4A11 - arachidonic acid metabolic factor (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003881
Super-classes obo:TXPO_0001859c
Restrictions obo:RO_0000087op some obo:TXPO_0003887c
obo:TXPO_0000819op some obo:OGG_3000001579c

negative regulation of arachidonic acid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003882
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0003884c
Sub-classes obo:TXPO_0003886c

hyperfunctioning of autophagyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003883
Super-classes obo:TXPO_0000435c
Restrictions obo:TXPO_0001502op some obo:GO_0006915c
Sub-classes obo:TXPO_0003889c

arachidonic acid metabolismc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003884
Super-classes obo:GO_0001676c
Sub-classes obo:TXPO_0003885c

omega-hydroxylase P450 pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003885
Super-classes obo:TXPO_0003884c

negative regulation of arachidonic acid metabolic process [phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003886
Super-classes obo:TXPO_0001716c
obo:TXPO_0003882c
Restrictions obo:RO_0000057op some obo:TXPO_0003881c
obo:RO_0002212op some obo:TXPO_0003884c
obo:RO_0000057op some obo:TXPO_0003582c
obo:TXPO_0000774op only obo:TXPO_0003382c

fatty acid omega-hydroxylase activityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003887
Super-classes obo:TXPO_0000519c

tumor progression inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003888
Super-classes obo:TXPO_0003230c
Restrictions obo:RO_0002599op some obo:TXPO_0000280c

Hyperfunctioning of apoptotic process [Phospholipidosis (excessive defense) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003889
Super-classes obo:TXPO_0003883c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000836c
obo:TXPO_0000774op only obo:TXPO_0002215c

TGF beta receptor signaling (primitive) [Phospholipidosis (excessive defense) - apoptosis inhibition ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003890
Super-classes obo:TXPO_0001853c
Restrictions obo:RO_0000057op some obo:TXPO_0003897c
obo:RO_0000057op some obo:TXPO_0003896c
obo:TXPO_0000069op some obo:TXPO_0003899c
obo:TXPO_0000774op only obo:TXPO_0002215c

TGFbeta (canonical)[Phospholipidosis - apotosis inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003891
Super-classes obo:TXPO_0003892c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c
obo:TXPO_0002260op some obo:IMR_0000008c

TGFB1(canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003892
Super-classes obo:IMR_0000042c
obo:TXPO_0003213c
obo:TXPO_1000371c
Restrictions obo:TXPO_0002260op some obo:IMR_0000041c
Sub-classes obo:TXPO_0003891c

TGFB1(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003893
Super-classes obo:TXPO_1000371c
obo:IMR_0000042c
obo:TXPO_0001135c
Restrictions obo:TXPO_0002260op some obo:IMR_0000041c
Sub-classes obo:TXPO_0003896c

FNIP2(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003894
Super-classes obo:TXPO_0001135c
obo:TXPO_0003837c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000057600c

Tgfb1(mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003895
Super-classes obo:TXPO_0003278c
obo:TXPO_1000371c
obo:IMR_0000042c
Restrictions obo:TXPO_0002260op some obo:IMR_0000041c
Sub-classes obo:TXPO_0003897c

TGFB1(canonical)[Phospholipidosis - apotosis inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003896
Super-classes obo:TXPO_0003893c
Restrictions obo:TXPO_0002260op some obo:IMR_0000041c
obo:RO_0000087op some obo:CHEBI_68494c

Tgfb1(mouse)[Phospholipidosis - apotosis inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003897
Super-classes obo:TXPO_0003895c
obo:TXPO_0003278c
obo:IMR_0000042c
Restrictions obo:TXPO_0002260op some obo:IMR_0000041c

degradation of Dab2c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003898
Super-classes obo:GO_0030163c
Sub-classes obo:TXPO_0003899c

degradation of Dab2 [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003899
Super-classes obo:TXPO_0001716c
obo:TXPO_0003898c
Restrictions obo:RO_0002233op some obo:TXPO_0003574c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0002233op some obo:TXPO_0003933c
obo:RO_0002233op some obo:TXPO_0003914c

DAB2(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003900
Description

PMID:19000037
Super-classes obo:TXPO_0001135c
obo:TXPO_0003841c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001601c
Sub-classes obo:TXPO_0003914c

smooth endoplasmic reticulum proliferation in hepatocyte [Ground glass appearance - Cyp]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003901
Super-classes obo:TXPO_0000963c
obo:TXPO_0001230c
Sub-classes obo:TXPO_0003903c

hyperfunction of drug metabolism phase II [Ground glass appearance - Cyp]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003902
Super-classes obo:TXPO_0000943c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0001663c

smooth endoplasmic reticulum proliferation in hepatocyte [Ground glass appearance - Cyp - PB]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003903
Super-classes obo:TXPO_0001230c
obo:TXPO_0003901c
Restrictions obo:BFO_0000051op some obo:TXPO_0003953c
Sub-classes obo:TXPO_0001677c

clonal expansion of preneoplastic cell [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003904
Description

Inhibition of apoptosis by phenobarbital promotes clonal expansion of preneoplastic cells.
Super-classes obo:TXPO_0003867c
obo:TXPO_0001728c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0002319c
obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of epidermal growth factor receptor signaling pathway [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003905
Super-classes obo:GO_0042059c
obo:TXPO_0001728c
Restrictions obo:RO_0002234op some obo:TXPO_0003913c
obo:TXPO_0000069op some obo:TXPO_0003918c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0001868op some obo:TXPO_0003906c
obo:RO_0002233op some obo:TXPO_0003912c

phenobarbital -EGFR signalling inhibitor [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003906
Super-classes obo:TXPO_0001524c
Restrictions obo:RO_0000087op some obo:TXPO_0003911c

Cyp2b10 (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003907
Description

species:mice
Super-classes obo:TXPO_1000102c
obo:TXPO_0001071c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

Cyp3a11 (mouse)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003908
Super-classes obo:TXPO_0001071c
obo:TXPO_1000106c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

CYP3A4 (human)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003909
Super-classes obo:TXPO_0001009c
obo:TXPO_1000082c
Restrictions obo:OGG_0000000016op some obo:NCBITaxon_9606c

CITCO [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003910
Super-classes obo:TXPO_0000560c
obo:TXPO_1000069c

EGFR pathway negative regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003911
Super-classes obo:CHEBI_76932c

EGFR (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003912
Super-classes obo:TXPO_0000472c
obo:IMR_0000081c
Restrictions obo:TXPO_0002260op some obo:IMR_0000081c
Sub-classes obo:TXPO_0003913c

EGFR - inactivation (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003913
Super-classes obo:TXPO_0003912c
Restrictions obo:RO_0000086op some obo:PATO_0002355c
obo:TXPO_0002260op some obo:IMR_0000081c

DAB2(human)[Phospholipidosis - apotosis inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003914
Description

PMID:19000037
Super-classes obo:TXPO_0003900c
Restrictions obo:RO_0000087op some obo:CHEBI_68495c
obo:TXPO_0000819op some obo:OGG_3000001601c

ALAS1(predicted)(human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003915
Description

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis.
Super-classes obo:TXPO_0001786c
obo:TXPO_1000034c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000000211c
obo:TXPO_0000756op some ncicp:C15958c

DAB2(mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003916
Description

PMID:19000037
Super-classes obo:TXPO_0003841c
obo:TXPO_0003278c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001601c
Sub-classes obo:TXPO_0003933c

Translocation of CAR from the cytosol to the nucleusc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003917
Super-classes obo:GO_0051169c
Restrictions obo:RO_0002339op some obo:GO_0005634c
obo:RO_0002338op some obo:GO_0005829c
Sub-classes obo:TXPO_0003918c

Translocation of CAR from the cytosol to the nucleus [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003918
Super-classes obo:TXPO_0001728c
obo:TXPO_0003917c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0000967c

hypofunction of gluconeogenesis [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003919
Super-classes obo:TXPO_0001728c
obo:TXPO_0003920c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003926c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003943c

hypofunction of gluconeogenesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003920
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000716op some obo:GO_0006094c
Sub-classes obo:TXPO_0003919c

AMPK activation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003921
Description

AMPK is sensitive to energy charge, which is activated by an increase in the ratio of AMP/ATP.
Super-classes obo:TXPO_0000405c
obo:TXPO_0001728c
Restrictions obo:TXPO_0001868op some obo:TXPO_0003922c
obo:RO_0002233op some obo:TXPO_0000944c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0002234op some obo:TXPO_0003948c
Sub-classes obo:TXPO_0003979c

phenobarbital - gluconeogenic inhibitor [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003922
Super-classes obo:TXPO_0001524c
Restrictions obo:RO_0000087op some obo:TXPO_0003929c

FOXO1 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003923
Super-classes obo:TXPO_0000472c
obo:IMR_0002805c
Restrictions obo:TXPO_0002260op some obo:IMR_0002805c
obo:RO_0000087op some obo:TXPO_0003947c
Sub-classes obo:TXPO_0003924c

FOXO1 - inactive form (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003924
Super-classes obo:IMR_0002805c
obo:TXPO_0003923c
Restrictions obo:RO_0000086op some obo:PATO_0002355c
obo:TXPO_0002260op some obo:IMR_0002805c

negative regulation of ATP consuming via CAR activation (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003925
Super-classes obo:TXPO_0003954c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003952c
obo:BFO_0000051op some obo:TXPO_0003932c
obo:TXPO_0000069op some obo:TXPO_0001028c

negative regulation of gluconeogenesis [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003926
Super-classes obo:GO_0045721c
obo:TXPO_0001728c
Restrictions obo:BFO_0000051op some obo:TXPO_0003936c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0003942c
obo:TXPO_0000069op some obo:TXPO_0000977c
obo:RO_0002234op some obo:TXPO_0003924c
obo:TXPO_0000069op some obo:TXPO_0003954c
obo:RO_0002233op some obo:TXPO_0003923c
obo:BFO_0000051op some obo:TXPO_0003919c
Sub-classes obo:TXPO_0003932c

GLUCOSE-6- phosphatase - gluconeogenic (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003927
Super-classes obo:TXPO_0001797c
Restrictions obo:RO_0000087op some obo:TXPO_0003928c

gluconeogenic factorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003928
Super-classes obo:TXPO_0003712c

gluconeogenesis inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003929
Super-classes obo:TXPO_0003949c
Restrictions obo:RO_0002599op some obo:GO_0006094c

CAR -FOXO1 transcriptional repression factor (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003930
Super-classes obo:TXPO_0003791c
Restrictions obo:RO_0000087op some obo:TXPO_0003946c

AMPK - inhibitor (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003931
Super-classes obo:TXPO_0000944c
Restrictions obo:RO_0000087op some obo:TXPO_0003929c

negative regulation of gluconeogenesis (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003932
Super-classes obo:TXPO_0003926c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003925c
obo:TXPO_0000069op some obo:TXPO_0000977c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:BFO_0000051op some obo:TXPO_0003944c
obo:BFO_0000051op some obo:TXPO_0003945c

Dab2(mouse)[Phospholipidosis - apotosis inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003933
Description

PMID:19000037
Super-classes obo:TXPO_0003916c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001601c
obo:RO_0000087op some obo:CHEBI_68495c

AMPK activatorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003934
Super-classes obo:TXPO_0003714c

FOXO1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003935
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:IMR_0002805c and ub744bL96382C17c)
Sub-classes obo:TXPO_0003936c

FOXO1 inactivation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003936
Super-classes obo:TXPO_0003935c
obo:TXPO_0001728c
Restrictions obo:RO_0002233op some obo:TXPO_0003923c
obo:TXPO_0001868op some obo:TXPO_0003930c
obo:TXPO_0000069op some obo:TXPO_0003942c
obo:RO_0002234op some obo:TXPO_0003924c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003945c

regulation of gluconeogenesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003937
Super-classes obo:GO_0010468c
Sub-classes obo:TXPO_0003938c

negative regulation of gluconeogenesis gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003938
Super-classes obo:TXPO_0003937c
Sub-classes obo:TXPO_0003939c

negative regulation of gluconeogenesis gene expression [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003939
Super-classes obo:TXPO_0003938c

negative regulation of G6Pase expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003940
Super-classes obo:GO_0010629c
Sub-classes obo:TXPO_0003942c

CTSB (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003941
Super-classes obo:TXPO_0001135c
obo:TXPO_0003843c
Restrictions obo:TXPO_0000043op some obo:GO_0005764c
obo:TXPO_0000819op some obo:OGG_3000001508c
Sub-classes obo:TXPO_0003879c
obo:TXPO_0003993c
obo:TXPO_0003878c
obo:TXPO_0004142c

negative regulation of glucogenesis related gene expression [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003942
Super-classes obo:TXPO_0003940c
obo:TXPO_0001728c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003919c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003944c

hypofunction of gluconeogenesis (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003943
Super-classes obo:TXPO_0003919c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003932c
obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of glucogenesis related gene expression (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003944
Super-classes obo:TXPO_0003942c
()
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003943c

FOXO1 inactivation (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003945
Super-classes obo:TXPO_0003936c
Restrictions obo:RO_0002234op some obo:TXPO_0003924c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003944c
obo:RO_0002233op some obo:TXPO_0003923c
obo:TXPO_0001868op some obo:TXPO_0003930c

trannscriptional repressor of FOXO1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003946
Super-classes obo:TXPO_0001531c

positive regulator of gluconeogenic gene transcription rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003947
Super-classes obo:TXPO_0000330c

AMPK - activation state (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003948
Super-classes obo:TXPO_0000944c

carbohydrate sysnthesis regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003949
Super-classes obo:TXPO_0004023c
Sub-classes obo:TXPO_0003929c

increasing AMP/ATP ratioc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003950
Super-classes obo:TXPO_0000352c
Sub-classes obo:TXPO_0003951c

increasing AMP/ATP ratio [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003951
Super-classes obo:TXPO_0001728c
obo:TXPO_0003950c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c
obo:TXPO_0000069op some obo:TXPO_0003953c
Sub-classes obo:TXPO_0003952c

increasing AMP/ATP ratio (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003952
Super-classes obo:TXPO_0003951c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003979c
obo:TXPO_0000069op some obo:TXPO_0003865c
obo:TXPO_0000774op only obo:TXPO_0001432c

regulation of generation of precursor metabolites and energy by phenobarbital [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003953
Super-classes obo:TXPO_0001619c
Restrictions obo:BFO_0000051op some obo:TXPO_0003951c
obo:BFO_0000051op some obo:TXPO_0003954c
obo:TXPO_0000069op some obo:TXPO_0003903c
Sub-classes obo:TXPO_0003865c

negative regulation of ATP consuming via CAR activation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003954
Super-classes obo:TXPO_0000945c
Restrictions obo:BFO_0000051op some obo:TXPO_0003926c
obo:BFO_0000051op some obo:TXPO_0003969c
obo:TXPO_0000069op some obo:TXPO_0003951c
obo:BFO_0000051op some obo:TXPO_0003956c
obo:TXPO_0000774op only obo:TXPO_0001432c
Sub-classes obo:TXPO_0003925c

constitutive androstane receptor activation by phenobarbital_2 [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003955
Description

Phenobarbital indirectly activates CAR and CAR translocates from the cytoplasm to the nucleus.
Super-classes obo:TXPO_0000935c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003954c
obo:RO_0002234op some obo:TXPO_0003977c
obo:TXPO_0000774op only obo:TXPO_0001432c

negative regulation of lipid biosynthetic process [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003956
Super-classes obo:TXPO_0001728c
obo:GO_0051055c
Restrictions obo:BFO_0000051op some obo:TXPO_0003958c
obo:BFO_0000051op some obo:TXPO_0003961c
obo:BFO_0000051op some obo:TXPO_0003960c
obo:TXPO_0001868op some obo:TXPO_0003957c
obo:TXPO_0000774op only obo:TXPO_0001432c

AMPK - lipogenic inhibitor (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003957
Super-classes obo:TXPO_0000944c

SREBP1 inactivation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003958
Super-classes obo:TXPO_0003959c
obo:TXPO_0001728c
Restrictions obo:RO_0002234op some obo:TXPO_0003965c
obo:TXPO_0000069op some obo:TXPO_0003960c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0002233op some obo:TXPO_0003964c
obo:TXPO_0000069op some obo:TXPO_0003961c

SREBP1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003959
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0003966c and ub744bL96738C17c)
Sub-classes obo:TXPO_0003958c

decreasing cholesterol [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003960
Super-classes obo:TXPO_0001728c
obo:TXPO_0003963c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

decreasing hepatic triglyceride [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003961
Super-classes obo:TXPO_0001728c
obo:TXPO_0003962c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001432c

decreasing hepatic triglyceridec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003962
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0003961c

decreasing cholesterolc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003963
Super-classes obo:TXPO_0000644c
Sub-classes obo:TXPO_0003960c

SREBP1 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003964
Super-classes obo:TXPO_0000472c
obo:TXPO_0003966c
Restrictions obo:RO_0000087op some obo:TXPO_0003968c
obo:RO_0000087op some obo:TXPO_0003967c
Sub-classes obo:TXPO_0003965c

SREBP1 - inactive form (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003965
Super-classes obo:TXPO_0003964c
Restrictions obo:TXPO_0001733op some obo:PATO_0002355c

SREBF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003966
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003964c
obo:TXPO_0003812c

lipid synthesis positive regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003967
Super-classes obo:TXPO_0002196c
Sub-classes obo:TXPO_0003968c
obo:TXPO_0003973c

cholesterol synthesis positive regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003968
Super-classes obo:TXPO_0003967c

hyperfunction of mitochondrial fatty acid beta-oxidation [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003969
Super-classes obo:TXPO_0002344c
obo:TXPO_0001728c
Restrictions obo:RO_0000057op some obo:TXPO_0003976c
obo:RO_0000057op some obo:TXPO_0003972c
obo:TXPO_0000774op only obo:TXPO_0001432c

ACC (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003970
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001401c
obo:TXPO_0003971c

ACC1 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003971
Super-classes obo:TXPO_0000472c
obo:TXPO_0003970c
Restrictions obo:RO_0000087op some obo:TXPO_0003973c
Sub-classes obo:TXPO_0003972c

ACC1 - inactive form (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003972
Super-classes obo:TXPO_0003971c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

fatty acid synthesis positive regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003973
Super-classes obo:TXPO_0003967c

ACACB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003974
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003975c

ACC2 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003975
Super-classes obo:TXPO_0000472c
obo:TXPO_0003974c
Restrictions obo:RO_0000087op some obo:TXPO_0003973c
Sub-classes obo:TXPO_0003976c

ACC2 - inactive form (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003976
Super-classes obo:TXPO_0003975c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

CAR - gluconeogenic inhibitor (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003977
Super-classes obo:TXPO_0003791c
Restrictions obo:RO_0000087op some obo:TXPO_0003929c

negative regulation of ATP consumingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003978
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0001165c
Sub-classes obo:TXPO_0000945c

AMPK activation (sustained) [Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003979
Description

AMPK is sensitive to energy charge, which is activated by an increase in the ratio of AMP/ATP.
Super-classes obo:TXPO_0003921c
obo:TXPO_0000405c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001028c
obo:TXPO_0001868op some obo:TXPO_0003922c
obo:RO_0002233op some obo:TXPO_0000944c
obo:RO_0002234op some obo:TXPO_0003948c
obo:TXPO_0000774op only obo:TXPO_0001432c
obo:RO_0000057op some obo:TXPO_0003980c

ARK5 (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003980
Super-classes obo:TXPO_0003982c
obo:TXPO_0000472c

NUAKc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003981
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003982c

NUAK1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003982
Super-classes obo:TXPO_0003981c
Sub-classes obo:TXPO_0003980c

Myc (rat)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003983
Super-classes obo:IMR_0000383c
obo:TXPO_0000985c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c
obo:TXPO_0002260op some obo:IMR_0000383c

sphingomyelin homeostasis imbalance [Phospholipidosis - genetic]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003984
Super-classes obo:TXPO_0004159c
obo:TXPO_0000907c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001685c
obo:BFO_0000051op some obo:TXPO_0001768c
obo:TXPO_0000069op some obo:TXPO_0001690c
Sub-classes obo:TXPO_0003988c

phospholipid homeostasis imbalance [Phospholipidosis - genetic]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003985
Super-classes obo:TXPO_0000907c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002070c
obo:BFO_0000051op some obo:TXPO_0001776c
obo:TXPO_0001733op some (obo:TXPO_0000493c or obo:TXPO_0002327c)
obo:TXPO_0000774op only obo:TXPO_0002215c

sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003986
Super-classes obo:TXPO_0003988c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001815c
obo:TXPO_0001733op some obo:TXPO_0002327c
obo:BFO_0000051op some obo:TXPO_0001482c

sphingomyelin homeostasis imbalance [Niemann Pick Disease Type B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003987
Super-classes obo:TXPO_0003988c
Restrictions obo:BFO_0000051op some obo:TXPO_0001816c
obo:TXPO_0000069op some obo:TXPO_0001809c
obo:TXPO_0000774op only obo:TXPO_0002215c

sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A/ B]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003988
Super-classes obo:TXPO_0003984c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000069op some obo:TXPO_0001807c
obo:BFO_0000051op some obo:TXPO_0001476c
Sub-classes obo:TXPO_0005143c
obo:TXPO_0003987c
obo:TXPO_0003986c

competitive inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003989
Super-classes obo:CHEBI_35222c

leukocyte infiltrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003990
Super-classes obo:TXPO_0000540c

glutathione conjugationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003991
Description

Glutathione S-Transferases (GSTs; EC 2.5.1.18) are another major set of phase II conjugation enzymes. They can be found in the cytosol as well as being microsomal membrane-bound. Cytosolic GSTs are encoded by at least 5 gene families (alpha, mu, pi, theta and zeta GST) whereas membrane-bound enzymes are encoded by single genes. Soluble GSTs are homo- or hetero-dimeric enzymes (approximately 25KDa subunits) which can act on a wide range of endogenous and exogenous electrophiles. GSTs mediate conjugation using glutathione (GSH), a tripeptide synthesized from its precursor amino acids gamma-glutamate, cysteine and glycine. A generalized reaction isRX + GSH -> HX + GSRGlutathione conjugates are excreted in bile and converted to cysteine and mercapturic acid conjugates in the intestine and kidneys. GSH is the major, low molecular weight, non-protein thiol synthesized de novo in mammalian cells. As well as taking part in conjugation reactions, GSH also has antioxidant ability and can metabolize endogenous and exogenous compounds. The nucleophilic GSH attacks the electrophilic substrate forming a thioether bond between the cysteine residue of GSH and the electrophile. The result is generally a less reactive and more water-soluble conjugate that can be easily excreted. In some cases, GSTs can activate compounds to reactive species such as certain haloalkanes and haloalkenes. Substrates for GSTs include epoxides, alkenes and compounds with electrophilic carbon, sulfur or nitrogen centres. There are two types of conjugation reaction with glutathione: displacement reactions where glutathione displaces an electron-withdrawing group and addition reactions where glutathione is added to activated double bond structures or strained ring systems.
Super-classes obo:GO_0006749c
Sub-classes obo:TXPO_0001923c
obo:TXPO_0001605c

toxicological imbalancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003992
Super-classes obo:TXPO_0000270c
Restrictions obo:BFO_0000051op some (obo:TXPO_0001734c and obo:TXPO_0001735c and obo:TXPO_0001746c and ub744bL97155C17c and obo:TXPO_0001736c and ub744bL97133C17c)
obo:BFO_0000051op some (obo:TXPO_0001734c and obo:TXPO_0001735c and obo:TXPO_0001746c and ub744bL97155C17c and obo:TXPO_0001736c and ub744bL97133C17c)
obo:BFO_0000051op some (obo:TXPO_0001734c and obo:TXPO_0001735c and obo:TXPO_0001746c and ub744bL97155C17c and obo:TXPO_0001736c and ub744bL97133C17c)
Sub-classes obo:TXPO_0002327c
obo:TXPO_0002076c
obo:TXPO_0000680c
obo:TXPO_0002228c
obo:TXPO_0001780c
obo:TXPO_0001779c
obo:TXPO_0000493c
obo:TXPO_0000679c

CTSB- apoptosis inhibitor (human)[Phospholipidosis - tumor metasitasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003993
Super-classes obo:TXPO_0003941c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c
obo:RO_0000087op some obo:CHEBI_68494c

Pik3c2g [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003994
Description

Phosphoinositide (PI) 3-kinases have been shown to have critical roles in signaling pathways that regulate proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.
Super-classes obo:TXPO_1000303c
obo:TXPO_0000837c

protooncogene rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003995
Description

Normal cellular genes at a stage prior to carcinogenesis. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc.
Super-classes obo:CHEBI_52209c

Ctsb (mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003996
Super-classes obo:TXPO_0003843c
obo:TXPO_0003278c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c
obo:TXPO_0000043op some obo:GO_0005764c
Sub-classes obo:TXPO_0003998c
obo:TXPO_0003999c
obo:TXPO_0004000c
obo:TXPO_0004140c

chaperone rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003997
Super-classes obo:TXPO_0003712c

Ctsb- apoptosis inhibitor (mouse)[Phospholipidosis - apoptosis inhibitor]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003998
Super-classes obo:TXPO_0003996c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c
obo:RO_0000087op some obo:CHEBI_68494c

Ctsb- tumor cell metastasis factor (human)[Phospholipidosis - tumor metasitasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0003999
Super-classes obo:TXPO_0003996c
Restrictions obo:RO_0000087op some obo:TXPO_0003880c
obo:TXPO_0000819op some obo:OGG_3000001508c

Ctsb- apoptosis inhibitor (mouse)[Phospholipidosis - tumor metasitasis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004000
Super-classes obo:TXPO_0003996c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c
obo:RO_0000087op some obo:TXPO_0000487c

recycling endososomal dysfunction [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004001
Super-classes obo:TXPO_0004002c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

recycling endosome dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004002
Super-classes obo:TXPO_0000438c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000066op some obo:GO_0005768c
Sub-classes obo:TXPO_0004001c

Alas1 (mouse) [Lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004003
Description

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis.
Super-classes obo:TXPO_1000034c
obo:TXPO_0001105c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000756op some obo:TXPO_0000489c
obo:TXPO_0000819op some obo:OGG_3000000211c

hyperfunction of heme biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004004
Super-classes obo:TXPO_0002346c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0001502op some obo:GO_0006783c
Sub-classes obo:TXPO_0001856c

Pcca [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004005
Super-classes obo:TXPO_0000837c
obo:TXPO_1000295c

PPARA lipid metabolism regulator (canonical)[Eosinophilic granular degeneration]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004006
Super-classes obo:TXPO_0001328c
Restrictions obo:RO_0000087op some obo:TXPO_0002358c

ADH1B(predicted)(human)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004007
Description

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis.
Super-classes obo:TXPO_0001786c
obo:TXPO_0001092c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000125c
obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000756op some ncicp:C15958c

tumor tissuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004008
Super-classes obo:TXPO_0004047c

hypofunction of endocytic recyclingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004009
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:GO_0032456c
Sub-classes obo:TXPO_0004010c

hypofunction of endocytic recycling [Phospholipidosis (severe) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004010
Super-classes obo:TXPO_0001716c
obo:TXPO_0004009c
Restrictions obo:TXPO_0000716op some obo:GO_0032456c
obo:TXPO_0000774op only obo:TXPO_0002215c

ADH1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004011
Super-classes obo:TXPO_0001094c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000125c

Adh1 (mouse)[lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004012
Super-classes obo:TXPO_0001094c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000125c

MAP2K6 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004013
Super-classes obo:TXPO_1000234c
obo:TXPO_0000837c

negative regulation of release of arachidonic acid from cell membranec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004014
Super-classes obo:TXPO_0000369c
Restrictions obo:TXPO_0000716op some obo:TXPO_0000457c
Sub-classes obo:TXPO_0004032c

Dissociation of FLCN:FNIP complex [Phospholipidosis (severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004015
Super-classes obo:TXPO_0001716c
obo:TXPO_0004016c
Restrictions obo:RO_0000057op some obo:TXPO_0003894c
obo:RO_0000057op some obo:TXPO_0004018c
obo:TXPO_0000069op some obo:TXPO_0004034c
obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0000057op some obo:TXPO_0002579c
obo:BFO_0000051op some obo:TXPO_0004049c

Dissociation of FLCN:FNIP complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004016
Super-classes obo:TXPO_0000462c
Restrictions obo:RO_0002234op some obo:TXPO_0003157c
obo:TXPO_0000069op some obo:TXPO_0000713c
obo:TXPO_0000774op only obo:TXPO_0002528c
obo:RO_0002234op some obo:TXPO_0000878c
Sub-classes obo:TXPO_0004015c

FAS (canonical) [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004017
Super-classes obo:TXPO_1000139c
obo:TXPO_0000837c

Fnip2(mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004018
Super-classes obo:TXPO_0003278c
obo:TXPO_0003837c

FLCN(canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004019
Description

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Super-classes obo:TXPO_0003213c
obo:TXPO_1000148c
Restrictions obo:RO_0000087op some obo:TXPO_0004043c

MTOR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004020
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004836c
obo:TXPO_0004026c

Rad51b [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004021
Super-classes obo:TXPO_0000837c
obo:TXPO_1000322c

Abc1b1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004022
Super-classes obo:TXPO_1000015c
obo:TXPO_0000837c
Restrictions obo:RO_0000087op some obo:TXPO_0000331c

metabolic regulator rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004023
Super-classes obo:TXPO_0003230c
Sub-classes obo:TXPO_0003654c
obo:TXPO_0003949c
obo:TXPO_0002358c
obo:TXPO_0004314c
obo:TXPO_0002037c
obo:TXPO_0002031c
obo:TXPO_0003648c

FLCN [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004024
Description

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Super-classes obo:TXPO_0000837c
obo:TXPO_1000148c

Cd44 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004025
Super-classes obo:TXPO_0000837c
obo:IMR_0000649c

MTOR (canonical) [phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004026
Super-classes obo:TXPO_0003213c
obo:TXPO_0004020c

Hist1h2bcl1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004027
Super-classes obo:TXPO_0000837c
obo:TXPO_1000194c

TOR signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004028
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0031929c
Sub-classes obo:TXPO_0004419c
obo:TXPO_0004034c

ZNF385B [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004029
Super-classes obo:TXPO_1000406c
obo:TXPO_0000837c

Eif4a1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004030
Super-classes obo:TXPO_1000133c
obo:TXPO_0000837c

Irf1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004031
Super-classes obo:TXPO_0000837c
obo:TXPO_1000212c

negative regulation of release of arachidonic acid from cell membrane [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004032
Super-classes obo:TXPO_0001716c
obo:TXPO_0004014c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0000716op some obo:TXPO_0000457c
obo:TXPO_0000069op some obo:TXPO_0003886c

HDGFRP3 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004033
Description

Enhances DNA synthesis and may play a role in cell proliferation.
Super-classes obo:TXPO_1000183c
obo:TXPO_0000837c

TOR signaling (primitive)　[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004034
Super-classes obo:TXPO_0001716c
obo:TXPO_0004028c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:TXPO_0001868op some obo:TXPO_0004026c
obo:TXPO_0002524op some obo:GO_0031929c

release of tumor inhibitor from lysosomec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004035
Super-classes obo:TXPO_0002588c
Sub-classes obo:TXPO_0004040c

SESN1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004036
Super-classes obo:TXPO_1000337c
obo:TXPO_0000837c

GDF15 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004037
Super-classes obo:TXPO_0000837c
obo:TXPO_1000164c

Pias3 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004038
Super-classes obo:TXPO_1000301c
obo:TXPO_0000837c

Ugt2b7 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004039
Super-classes obo:TXPO_0000837c
obo:TXPO_1000398c

release of tumor inhibitor from lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004040
Super-classes obo:TXPO_0001716c
obo:TXPO_0004035c
Restrictions obo:RO_0002234op some obo:TXPO_0004019c
obo:BFO_0000051op some obo:TXPO_0004034c
obo:TXPO_0000069op some obo:TXPO_0001491c
obo:BFO_0000051op some obo:TXPO_0004015c
obo:TXPO_0000774op only obo:TXPO_0003382c

SRSF1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004041
Super-classes obo:TXPO_1000352c
obo:TXPO_0000837c

COL4A2 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004042
Super-classes obo:TXPO_0000837c
obo:TXPO_1000072c

negative regulator of tumor cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004043
Super-classes obo:TXPO_0004045c
obo:TXPO_0003534c
Restrictions obo:RO_0002598op some obo:GO_0008283c

Aen (rat)[Cell death]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004044
Super-classes obo:TXPO_0000839c
obo:TXPO_1000029c
Restrictions obo:TXPO_0000756op some ncicp:C15958c

negative regulator of cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004045
Super-classes obo:TXPO_0003159c
Restrictions obo:RO_0002598op some obo:GO_0008283c
Sub-classes obo:TXPO_0004043c

forming adductc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004046
Super-classes obo:TXPO_0000168c

abnormal cell tissuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004047
Super-classes obo:TXPO_0000065c
Sub-classes obo:NCIT_C3340c
obo:TXPO_0004008c

proteasome-mediated ubiquitin-dependent FNIP2 catabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004048
Super-classes obo:GO_0043161c
Sub-classes obo:TXPO_0004049c

proteasome-mediated FNIP2 degradation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004049
Super-classes obo:TXPO_0001716c
obo:TXPO_0004048c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0002233op some obo:TXPO_0003894c
obo:RO_0002233op some obo:TXPO_0004018c

HMGCS2 (predicted)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004050
Super-classes obo:TXPO_1000189c
obo:TXPO_0001135c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000003158c

C1orf162 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004051
Super-classes obo:TXPO_1000052c
obo:TXPO_0000837c

HMGCS2(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004052
Description

HMGCS2 transcription is heavily regulated by FOXA2, mTOR, PPARα, and FGF21.
Super-classes obo:TXPO_1000189c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003158c

PPARalpha activation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004053
Super-classes obo:TXPO_0000013c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001497c
obo:RO_0000057op some obo:TXPO_0004050c
obo:RO_0000057op some obo:TXPO_0004052c
obo:TXPO_0000774op only obo:TXPO_0003452c
obo:RO_0000057op some obo:TXPO_0004061c

CARMIL3 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004054
Super-classes obo:TXPO_0000837c
obo:TXPO_1000057c

Caspase-3 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004055
Super-classes obo:TXPO_0000837c
obo:TXPO_0001145c

CCNB2 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004056
Super-classes obo:TXPO_1000061c
obo:TXPO_0000837c

Ccng1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004057
Super-classes obo:TXPO_0000837c
obo:TXPO_1000089c

CENPE [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004058
Description

The CENPE gene encodes a large kinetochore-associated kinesin-like motor protein required for spindle microtubule capture and attachment at the kinetochore during cell division
Super-classes obo:TXPO_1000064c
obo:TXPO_0000837c

Cdkn1a [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004059
Super-classes obo:TXPO_0000837c
obo:TXPO_1000091c

Cenpw [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004060
Super-classes obo:TXPO_0000837c
obo:TXPO_1000092c

PPAR alpha [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004061
Super-classes obo:TXPO_0000159c
obo:TXPO_0003213c

Cpq [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004062
Super-classes obo:TXPO_1000096c
obo:TXPO_0000837c

CYP3A5 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004063
Super-classes obo:TXPO_0000837c
obo:TXPO_1000083c

EIF1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004064
Description

EIF1 (Eukaryotic Translation Initiation Factor 1) is a Protein Coding gene. Among its related pathways are Translation Factors and RNA transport. GO annotations related to this gene include poly(A) RNA binding and translation factor activity, RNA binding. An important paralog of this gene is EIF1B.
Super-classes obo:TXPO_0000837c
obo:IMR_0000908c

ketone biosynthetic process[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004065
Super-classes obo:GO_00042181c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0004052c
obo:TXPO_0000069op some obo:TXPO_0003592c
obo:RO_0000057op some obo:TXPO_0004050c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0003382c

hypofunction of anti-oxidative stressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004066
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0006979c
Sub-classes obo:TXPO_0004069c
obo:TXPO_0004370c

Glypican [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004067
Super-classes obo:IMR_0001139c
obo:TXPO_0000837c

GPC3 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004068
Super-classes obo:TXPO_0000837c
obo:TXPO_0000613c

hypofunction of anti-oxidative stress[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004069
Super-classes obo:TXPO_0004066c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001491c
obo:TXPO_0000069op some obo:TXPO_0001497c
obo:RO_0000057op some obo:TXPO_0004070c
obo:RO_0000057op some obo:TXPO_0003558c
obo:TXPO_0000774op only obo:TXPO_0002215c

Hmox1 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004070
Super-classes obo:TXPO_1000196c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003162c

Hist2h2aa3 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004071
Super-classes obo:TXPO_0000837c
obo:TXPO_1000195c

PLA2G15 (canonical) positively regulator of immune response[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004072
Description

PLA2G15 is to date the first and only identified lysosomal phospholipase A.
Super-classes obo:TXPO_0000775c
obo:TXPO_0003213c
Restrictions obo:RO_0000087op some obo:TXPO_0003671c
obo:RO_0000087op some obo:TXPO_0003572c
obo:TXPO_0002260op some obo:IMR_0000283c

INHBE [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004073
Super-classes obo:TXPO_1000203c
obo:TXPO_0000837c

Isyna1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004074
Super-classes obo:TXPO_1000213c
obo:TXPO_0000837c

ITGB1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004075
Super-classes obo:TXPO_1000206c
obo:TXPO_0000837c

JMJD6 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004076
Description

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008
Super-classes obo:TXPO_0000837c
obo:TXPO_1000214c

energy supplyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004077
Super-classes obo:TXPO_0000741c
Sub-classes obo:TXPO_0003595c
obo:TXPO_0003594c
obo:TXPO_0004136c

Mybl2 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004078
Super-classes obo:TXPO_1000246c
obo:TXPO_0000837c

positive regulation of cell deathc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004079
Super-classes obo:GO_0010941c
Restrictions obo:RO_0002213op some obo:GO_0008219c
Sub-classes obo:TXPO_0004122c

Nudt11 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004080
Super-classes obo:TXPO_0000837c
obo:TXPO_1000265c

negative regulation of mitochondrial electron transport, ubiquinol to cytochrome cc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004081
Super-classes obo:TXPO_0002342c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:RO_0002212op some obo:GO_0006122c
Sub-classes obo:TXPO_0004120c

negative regulation of cell deathc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004082
Super-classes obo:GO_0010941c
Restrictions obo:RO_0002212op some obo:GO_0008219c

Pcsk7 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004083
Super-classes obo:TXPO_1000296c
obo:TXPO_0000837c

negative regulation of potassium ion transport [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004084
Super-classes obo:GO_0043267c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0004087c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0003560c

positive regulation of macrophage derived foam cell differentiation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004085
Super-classes obo:GO_0010744c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0004086c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0000077c
obo:TXPO_0000069op some obo:TXPO_0004154c
Sub-classes obo:TXPO_0004160c
obo:TXPO_0000558c

ITGB3(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004086
Super-classes obo:TXPO_0003817c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003690c

KCNMA1(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004087
Super-classes obo:TXPO_0003839c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003778c

malfunctioning of insulin signaling [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004088
Super-classes obo:TXPO_0001716c
obo:TXPO_0001125c
Restrictions obo:RO_0000057op some obo:TXPO_0004092c
obo:RO_0000057op some obo:TXPO_0003560c
obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0000057op some obo:TXPO_0004090c

Rnase1l2 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004089
Super-classes obo:TXPO_0000837c
obo:TXPO_1000328c

insulin(canonical)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004090
Super-classes obo:IMR_0000052c
obo:TXPO_0003213c

Sub1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004091
Super-classes obo:TXPO_1000368c
obo:TXPO_0000837c

Kcnma1(mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004092
Super-classes obo:TXPO_0003839c
obo:TXPO_0003278c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003778c

TWIST1 [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004093
Super-classes obo:TXPO_1000380c
obo:TXPO_0000837c

Tyms [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004094
Super-classes obo:TXPO_1000391c
obo:TXPO_0000837c

MMAA (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004095
Super-classes obo:TXPO_0001135c
obo:TXPO_0003833c
Restrictions obo:TXPO_0000819op some obo:OGG_3000166785c

protein ubiquitinationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004096
Super-classes obo:TXPO_0004107c
Sub-classes obo:TXPO_0002727c

genetic information carrier rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004097
Super-classes obo:TXPO_0001393c

positive regulation of glutathione biosynthetic process [Glutathione depletion]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004098
Super-classes obo:GO_1903788c
obo:TXPO_0000889c
Restrictions obo:RO_0002213op some obo:GO_0006750c
obo:TXPO_0000774op only obo:TXPO_0000501c
obo:RO_0000057op some obo:TXPO_0001938c

negative regulation of mitochondrial electron transport, succinate to ubiquinonec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004099
Super-classes obo:TXPO_0002342c
Restrictions obo:RO_0002212op some obo:GO_0006121c
obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0004119c

malfunctioning of cobalamin biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004100
Super-classes obo:TXPO_0003267c
Sub-classes obo:TXPO_0004101c

malfunctioning of cobalamin biosynthetic process[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004101
Super-classes obo:TXPO_0001716c
obo:TXPO_0004100c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001708c
obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0000057op some obo:TXPO_0000659c
obo:RO_0000057op some obo:TXPO_0004095c

CAR - apotosis inhibitor (canonical)[Ground glass appearance]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004102
Super-classes obo:TXPO_0003791c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c

IL32 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004103
Super-classes obo:IMR_0000007c
Sub-classes obo:TXPO_0004104c

IL32 (human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004104
Super-classes obo:TXPO_0004103c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003558c
obo:RO_0000087op some obo:TXPO_0003041c

NCR3LG1 (predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004105
Super-classes obo:TXPO_0001135c
obo:TXPO_0003842c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c

PKIB(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004106
Super-classes obo:TXPO_0001135c
obo:TXPO_0003838c
Restrictions obo:RO_0000087op some obo:TXPO_0002272c
obo:TXPO_0000819op some obo:OGG_3000005570c

protein modification by small protein conjugationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004107
Super-classes obo:GO_0070647c
Sub-classes obo:GO_0016925c
obo:TXPO_0004096c

Rsad2(mouse)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004108
Super-classes obo:TXPO_0003278c
obo:TXPO_0003835c
Restrictions obo:TXPO_0000756op some obo:TXPO_0000489c

negative regulation of mitochondrial electron transport, NADH to ubiquinone [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004109
Super-classes obo:TXPO_0001987c
obo:GO_1902957c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:RO_0002212op some obo:GO_0006120c
obo:TXPO_0000774op only obo:TXPO_0001986c

lipid droplet formationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004110
Super-classes obo:GO_0034389c
Restrictions obo:RO_0000057op some obo:CHEBI_18059c
Sub-classes obo:TXPO_0004111c

lipid droplet formation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004111
Super-classes obo:TXPO_0001716c
obo:TXPO_0004110c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0000057op some obo:TXPO_0004108c
obo:RO_0000057op some obo:TXPO_0001903c
obo:RO_0000057op some obo:CHEBI_18059c

SPON2(predicted)(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004112
Super-classes obo:TXPO_0003834c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010417c
obo:RO_0000086op some obo:TXPO_0000657c

macrophage migration [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004113
Super-classes obo:TXPO_0001716c
obo:GO_1905517c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
obo:TXPO_0000069op some obo:TXPO_0000156c
obo:TXPO_0000069op some obo:TXPO_0001257c
obo:RO_0000057op some obo:TXPO_0004116c
obo:RO_0000057op some obo:TXPO_0004112c

SPON2(human) - tumor metastasis inhibitor[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004114
Super-classes obo:TXPO_0001789c
Restrictions obo:RO_0000087op some obo:TXPO_0004115c
obo:TXPO_0000819op some obo:OGG_3000010417c

tumor metastasis inhibitorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004115
Super-classes obo:TXPO_0003230c

SPON2(human) - immune responsor[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004116
Super-classes obo:TXPO_0001789c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010417c
obo:RO_0000087op some obo:TXPO_0002284c

hyperfunction of drug metabolism phase II [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004117
Super-classes obo:TXPO_0001716c
obo:TXPO_0001236c
Restrictions obo:RO_0000057op some obo:TXPO_0004118c
obo:RO_0000057op some obo:TXPO_0000078c
obo:TXPO_0000774op only obo:TXPO_0003382c

SULT1C2(human)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004118
Super-classes obo:TXPO_0003832c
obo:TXPO_0001135c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006819c

negative regulation of mitochondrial electron transport, succinate to ubiquinone [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004119
Super-classes obo:TXPO_0001987c
obo:TXPO_0004099c
Restrictions obo:RO_0002212op some obo:GO_0006121c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0001986c

negative regulation of mitochondrial electron transport, ubiquinol to cytochrome c [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004120
Super-classes obo:TXPO_0001987c
obo:TXPO_0004081c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op some obo:GO_0005739c
obo:RO_0002212op some obo:GO_0006122c

DNA damage [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004121
Super-classes obo:NCIT_C16507c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003568c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:RO_0000057op some obo:TXPO_0004337c
obo:RO_0000057op some obo:TXPO_0004331c
obo:TXPO_0000069op some obo:TXPO_0004218c
obo:TXPO_0000069op some obo:TXPO_0001990c

positive regulation of tumor cell deathc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004122
Super-classes obo:TXPO_0004079c
Restrictions obo:RO_0002213op some obo:GO_0008219c
Sub-classes obo:TXPO_0004123c

positive regulation of tumor cell death [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004123
Super-classes obo:TXPO_0004122c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0000057op some obo:TXPO_0001395c
obo:RO_0002213op some obo:TXPO_0004129c

negative regulation of heat generation [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004124
Super-classes obo:TXPO_0001987c
obo:TXPO_0002054c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002212op some obo:GO_0031649c

negative regulation of oxidative phosphorylation [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004125
Super-classes obo:TXPO_0001771c
obo:TXPO_0001987c
Restrictions obo:BFO_0000051op some obo:TXPO_0004135c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0002230c
obo:RO_0002212op some obo:GO_0006119c
obo:TXPO_0000069op some obo:TXPO_0002005c
obo:TXPO_0000069op some obo:TXPO_0000075c

malfunctioning of TCA cycle [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004126
Super-classes obo:TXPO_0001987c
obo:TXPO_0001269c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004373c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0004127c
obo:TXPO_0000069op some obo:TXPO_0004125c
obo:TXPO_0000069op some obo:TXPO_0001989c
obo:TXPO_0000069op some obo:TXPO_0004371c
obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000069op some obo:TXPO_0004372c

increasing acetyl CoA [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004127
Super-classes obo:TXPO_0001987c
obo:TXPO_0000088c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004374c
obo:TXPO_0000069op some obo:TXPO_0002005c
obo:TXPO_0000774op only obo:TXPO_0001986c

increasing volume of mitochondria [lipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004128
Super-classes obo:TXPO_0000143c
obo:TXPO_0001720c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001155c
obo:RO_0002233op some obo:GO_0005739c
obo:RO_0002234op some (obo:GO_0005739c and ub744bL98791C17c)

tumor cell deathc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004129
Super-classes obo:GO_0008219c
Restrictions obo:RO_0002233op some (obo:CL_0000000c and ub744bL98823C17c)

increasing uptake amount of mitochondrial proton ionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004130
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004131c

increasing uptake amount of mitochondrial proton ion [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004131
Super-classes obo:TXPO_0004130c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001879c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004135c

negative regulation of tumor cell proliferation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004132
Super-classes obo:TXPO_0001716c
obo:TXPO_0002124c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c

oxidative phosphorylation uncouplingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004133
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006119c
Sub-classes obo:TXPO_0002039c

positive regulation of oxidative phosphorylation uncouplingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004134
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:TXPO_0004133c
Sub-classes obo:TXPO_0004135c

positive regulation of oxidative phosphorylation uncoupling [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004135
Super-classes obo:TXPO_0001987c
obo:TXPO_0004134c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004125c
obo:TXPO_0000069op some obo:TXPO_0001989c
obo:RO_0002213op some obo:TXPO_0004133c

energy supply [Phospholipidosis(normal)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004136
Super-classes obo:TXPO_0004077c
obo:TXPO_0003595c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
obo:BFO_0000051op some obo:TXPO_0004137c

increasing energy [Phospholipidosis (normal)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004137
Super-classes obo:TXPO_0003593c
obo:TXPO_0000144c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c

decreasing energyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004138
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0004139c

decreasing energy [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004139
Super-classes obo:TXPO_0001716c
obo:TXPO_0004138c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c

Ctsb (mouse)[Niemann-Pick disease - fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004140
Super-classes obo:TXPO_0003996c
Restrictions obo:RO_0000087op some obo:CHEBI_68494c
obo:TXPO_0000819op some obo:OGG_3000001508c
obo:TXPO_0000756op some obo:TXPO_0000489c

hepatic fibrosis [Niemann-Pick disease]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004141
Super-classes obo:TXPO_0001716c
obo:TXPO_0000816c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
obo:RO_0000057op some obo:TXPO_0003788c
obo:TXPO_0000774op only obo:TXPO_0001462c
obo:RO_0000057op some obo:TXPO_0004142c
obo:RO_0000057op some obo:TXPO_0004140c

CTSB (human)Niemann-Pick disease - fibrosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004142
Super-classes obo:TXPO_0003941c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001508c

ceramide acumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004143
Super-classes obo:GO_0019915c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0002083c
obo:TXPO_0004964c

extracellular matrix disassembly [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004144
Super-classes obo:GO_0022411c
obo:TXPO_0001716c
Restrictions obo:RO_0000057op some obo:TXPO_0003879c
obo:TXPO_0000774op only obo:TXPO_0002215c
obo:RO_0002233op some obo:GO_0031012c
obo:RO_0000057op some obo:TXPO_0003788c
obo:TXPO_0000069op some obo:TXPO_0001497c
obo:RO_0000057op some obo:TXPO_0003999c

hypofunction of cholesterol efflux from hepatoytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004145
Super-classes obo:TXPO_0001911c
Restrictions obo:TXPO_0000716op some obo:GO_0033344c
Sub-classes obo:TXPO_0004146c

hypofunction of cholesterol efflux [Niemann-pick disease]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004146
Super-classes obo:TXPO_0004145c
obo:TXPO_0001716c
Restrictions obo:TXPO_0000716op some obo:GO_0033344c
obo:RO_0000057op some obo:TXPO_0004147c
obo:TXPO_0000774op only obo:TXPO_0001462c

sphingomyelin [Niemann-Pick disease]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004147
Super-classes obo:TXPO_0001849c
obo:CHEBI_64583c

myelin figureformation in lysosome [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004148
Description

The presence of phospholipid inclusions are characterized by the presence of cytoplasmic vacuoles seen under the electron microscope as dense cytoplasmic myelin-like bodies showing a concentric lamellar structure with a periodicity of 4-4.5 nm along with an amorphorous matrix within a single membrane-bound lysosomal space.

Histopathology of preclinical toxicity studies : interpretation and relevance in drug safety studies, Peter Greaves. 4th ed. Amsterdam ; Boston : Elsevier/AP, 2012.
Super-classes obo:TXPO_0000322c
obo:TXPO_0001716c
Restrictions obo:BFO_0000066op some obo:GO_0005764c
obo:RO_0000057op some obo:TXPO_0003573c
obo:TXPO_0000069op some obo:TXPO_0001643c
obo:TXPO_0000774op only obo:TXPO_0003382c
obo:TXPO_0001873op some obo:TXPO_0003526c

ASPA(human) [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004149
Description

ASPA relates to myelination in the CNS, but not observed in the liver.
Super-classes obo:TXPO_0001135c
obo:TXPO_0003840c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000443c
obo:RO_0000086op some obo:TXPO_0000657c

Removing ceramide by Kupffer cell or macrophagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004150
Super-classes obo:TXPO_0000458c

hyperfunction of ceramide phagocytosis by Kupffer cell or macrophagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004151
Super-classes obo:TXPO_0001483c
Restrictions obo:TXPO_0001502op some obo:TXPO_0004150c
Sub-classes obo:TXPO_0000101c

acid ceramidase inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004152
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000009c and ub744bL99164C17c)
Sub-classes obo:TXPO_0004153c

acid ceramidase inactivation [Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004153
Super-classes obo:TXPO_0001716c
obo:TXPO_0004152c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003382c
obo:RO_0002234op some obo:TXPO_0003456c

increasing number of macrophage derived foam cell [Phospholipidosis(severe)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004154
Super-classes obo:TXPO_0000918c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c

phospholipid homeostasis imbalance [Phospholipidosis (mild) ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004155
Super-classes obo:TXPO_0000907c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001824c
obo:TXPO_0001733op some obo:TXPO_0000493c
obo:TXPO_0000716op some obo:TXPO_0001683c
obo:TXPO_0000774op only obo:TXPO_0003359c
obo:BFO_0000051op some obo:TXPO_0001777c

dysfunction of sphingomyelin degradation [Phospholipidosis-sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004156
Super-classes obo:TXPO_0001686c
obo:TXPO_0004162c
Restrictions obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0001687c

sphingomyelin disorder (phospholipidosis)　c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004157
Super-classes obo:TXPO_0002215c
Restrictions obo:BFO_0000051op some obo:TXPO_0004162c
obo:BFO_0000051op some obo:TXPO_0001788c
obo:BFO_0000051op some obo:TXPO_0001823c
obo:TXPO_0000004op only obo:TXPO_0001823c
obo:BFO_0000051op some obo:TXPO_0001595c
obo:BFO_0000051op some obo:TXPO_0003381c
obo:BFO_0000051op some obo:TXPO_0001569c
obo:BFO_0000051op some obo:TXPO_0004159c
obo:BFO_0000051op some obo:TXPO_0003445c
Sub-classes obo:TXPO_0001685c

lysosomal cholesterol storage (moderate)[Phospholipidosis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004158
Super-classes obo:TXPO_0000694c
Restrictions obo:TXPO_0000774op only obo:TXPO_0003369c
obo:TXPO_0000069op some obo:TXPO_0003370c

sphingomyelin homeostasis imbalance [Phospholipidosis - sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004159
Super-classes obo:TXPO_0000907c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003381c
obo:TXPO_0000774op only obo:TXPO_0004157c
obo:BFO_0000051op some obo:TXPO_0001823c
Sub-classes obo:TXPO_0003984c

positive regulation of macrophage derived foam cell differentiation [sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004160
Super-classes obo:TXPO_0004085c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004157c
obo:TXPO_0000069op some obo:TXPO_0004161c

increasing number of macrophage derived foam cell [Phospholipidosis(sphingomyelin disorder )]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004161
Super-classes obo:TXPO_0000918c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000101c
obo:TXPO_0000774op only obo:TXPO_0004157c

hypofunction of sphingomyelin degradation [Phospholipidosis-sphingomyelin disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004162
Super-classes obo:TXPO_0001676c
obo:TXPO_0000925c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004157c
obo:TXPO_0000069op some obo:TXPO_0001823c
obo:TXPO_0000069op some obo:TXPO_0001569c
obo:RO_0002234op some obo:TXPO_0003599c
Sub-classes obo:TXPO_0004156c

sphingomyelin metabolism imbalance [Phospholipidosis ]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004163
Super-classes obo:TXPO_0001672c
obo:TXPO_0002324c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003381c
obo:TXPO_0000774op only obo:TXPO_0002215c
Sub-classes obo:TXPO_0001823c

SLC38A4 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004164
Super-classes obo:TXPO_0003603c
obo:TXPO_1000534c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055089c
obo:RO_0000086op some obo:TXPO_0000657c

BCL2A1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004165
Super-classes obo:TXPO_0003603c
obo:TXPO_1000504c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000000597c

TRIM55 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004166
Super-classes obo:TXPO_1000542c
obo:TXPO_0003603c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084675c
obo:RO_0000086op some obo:TXPO_0000657c

CYP1A1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004167
Super-classes obo:TXPO_0003603c
obo:TXPO_1000511c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000001543c

PIM3 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004168
Super-classes obo:TXPO_1000525c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000415116c

GFRA1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004169
Super-classes obo:TXPO_1000516c
obo:TXPO_0003603c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002674c
obo:RO_0000086op some obo:TXPO_0000657c

ATAD2 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004170
Super-classes obo:TXPO_0003603c
obo:TXPO_1000503c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029028c
obo:RO_0000086op some obo:TXPO_0000657c

C9orf72 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004171
Super-classes obo:TXPO_1000054c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000203228c
Sub-classes obo:TXPO_0004441c

FEN1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004172
Super-classes obo:TXPO_1000515c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000002237c

SKA2 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004173
Super-classes obo:TXPO_1000533c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000348235c

TSKU (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004174
Super-classes obo:TXPO_0003603c
obo:TXPO_1000543c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000025987c

SEL1L (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004175
Super-classes obo:TXPO_0003603c
obo:TXPO_1000532c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000006400c

PCK1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004176
Super-classes obo:TXPO_0003603c
obo:TXPO_1000524c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005105c
obo:RO_0000086op some obo:TXPO_0000657c
Sub-classes obo:TXPO_0005123c

NEAT1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004177
Super-classes obo:TXPO_1000521c
obo:TXPO_0003603c
Restrictions obo:TXPO_0000819op some obo:OGG_3000283131c
obo:RO_0000086op some obo:TXPO_0000657c
Sub-classes obo:TXPO_0004234c

SRPX2 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004178
Super-classes obo:TXPO_0003603c
obo:TXPO_1000537c
Restrictions obo:TXPO_0000819op some obo:OGG_3000027286c
obo:RO_0000086op some obo:TXPO_0000657c

TMPO (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004179
Super-classes obo:TXPO_0003603c
obo:TXPO_1000540c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007112c
obo:RO_0000086op some obo:TXPO_0000657c

SLC3A1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004180
Super-classes obo:TXPO_0003603c
obo:TXPO_1000535c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006519c
obo:RO_0000086op some obo:TXPO_0000657c

RHNO1 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004181
Super-classes obo:TXPO_0003603c
obo:TXPO_1000529c
Restrictions obo:TXPO_0000819op some obo:OGG_3000083695c
obo:RO_0000086op some obo:TXPO_0000657c

ORC6 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004182
Super-classes obo:TXPO_1000522c
obo:TXPO_0003603c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023594c
obo:RO_0000086op some obo:TXPO_0000657c

CDCA5 (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004183
Super-classes obo:TXPO_1000506c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000113130c

UBE2T (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004184
Super-classes obo:TXPO_1000545c
obo:TXPO_0003603c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029089c
obo:RO_0000086op some obo:TXPO_0000657c

liver cancer dependent molecule (human in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004185
Super-classes obo:TXPO_0000837c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9606c
obo:TXPO_0000756op some ncicp:C15958c
Sub-classes obo:TXPO_0005097c
obo:TXPO_0004192c
obo:TXPO_0005095c
obo:TXPO_0004647c
obo:TXPO_0004201c
obo:TXPO_0004654c
obo:TXPO_0004950c
obo:TXPO_0004197c
obo:TXPO_0004291c
obo:TXPO_0005122c
obo:TXPO_0004611c
obo:TXPO_0004784c
obo:TXPO_0004879c
obo:TXPO_0004651c
obo:TXPO_0004801c
obo:TXPO_0004190c
obo:TXPO_0004951c
obo:TXPO_0004200c
obo:TXPO_0004682c
obo:TXPO_0004193c
obo:TXPO_0004194c
obo:TXPO_0005129c
obo:TXPO_0004458c
obo:TXPO_0004198c
obo:TXPO_0005121c
obo:TXPO_0004767c
obo:TXPO_0005075c
obo:TXPO_0004691c
obo:TXPO_0005131c
obo:TXPO_0004196c
obo:TXPO_0004187c
obo:TXPO_0004887c
obo:TXPO_0004626c
obo:TXPO_0004519c
obo:TXPO_0004855c
obo:TXPO_0004750c
obo:TXPO_0004812c
obo:TXPO_0004186c
obo:TXPO_0004204c
obo:TXPO_0004528c
obo:TXPO_0004792c
obo:TXPO_0004205c
obo:TXPO_0004189c
obo:TXPO_0005124c
obo:TXPO_0005006c
obo:TXPO_0004233c
obo:TXPO_0004191c
obo:TXPO_0004808c
obo:TXPO_0004889c
obo:TXPO_0004786c
obo:TXPO_0004202c
obo:TXPO_0004953c
obo:TXPO_0004852c
obo:TXPO_0004465c
obo:TXPO_0004415c
obo:TXPO_0004692c
obo:TXPO_0004199c
obo:TXPO_0004206c
obo:TXPO_0004857c
obo:TXPO_0004488c
obo:TXPO_0004780c
obo:TXPO_0004851c
obo:TXPO_0004858c
obo:TXPO_0004746c
obo:TXPO_0005089c
obo:TXPO_0005067c
obo:TXPO_0004236c
obo:TXPO_0004930c
obo:TXPO_0004203c
obo:TXPO_0004188c
obo:TXPO_0004195c
obo:TXPO_0004678c

PTPRD (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004186
Super-classes obo:TXPO_0004185c
obo:TXPO_1000527c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
Sub-classes obo:TXPO_0004786c

SCAPER (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004187
Super-classes obo:TXPO_1000531c
obo:TXPO_0004185c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000049855c

GPHN (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004188
Super-classes obo:TXPO_1000517c
obo:TXPO_0004185c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000010243c

ACSM2A (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004189
Super-classes obo:TXPO_0004185c
obo:TXPO_1000500c
Restrictions obo:TXPO_0000819op some obo:OGG_3000123876c
obo:RO_0000086op some obo:TXPO_0000657c

ACSM2B (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004190
Super-classes obo:TXPO_0004185c
obo:TXPO_1000501c
Restrictions obo:TXPO_0000819op some obo:OGG_3000348158c
obo:RO_0000086op some obo:TXPO_0000657c

SPTLC3 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004191
Super-classes obo:TXPO_0004185c
obo:TXPO_1000536c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000055304c

DPYD (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004192
Super-classes obo:TXPO_0004185c
obo:TXPO_1000514c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000001806c

KIAA0101 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004193
Super-classes obo:TXPO_1000520c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009768c
obo:RO_0000086op some obo:TXPO_0000657c
Sub-classes obo:TXPO_0004678c
obo:TXPO_0005097c
obo:TXPO_0004682c

HILPDA (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004194
Super-classes obo:TXPO_0004185c
obo:TXPO_1000518c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029923c
obo:RO_0000086op some obo:TXPO_0000657c

AGGF1 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004195
Super-classes obo:TXPO_1000502c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055109c
obo:RO_0000086op some obo:TXPO_0000657c

CLMN (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004196
Super-classes obo:TXPO_1000508c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079789c
obo:RO_0000086op some obo:TXPO_0000657c

RPS29 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004197
Super-classes obo:TXPO_0004185c
obo:TXPO_1000530c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006235c
obo:RO_0000086op some obo:TXPO_0000657c

CXCL8 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004198
Super-classes obo:TXPO_0004185c
obo:TXPO_1000510c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c

ZNF385B (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004199
Super-classes obo:TXPO_1000406c
obo:TXPO_0004185c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000151126c

PMAIP1 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004200
Super-classes obo:TXPO_0004185c
obo:TXPO_1000526c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000005366c
Sub-classes obo:TXPO_0004763c

UGT2A3 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004201
Super-classes obo:TXPO_0004185c
obo:TXPO_1000546c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000079799c

CYP1A2 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004202
Super-classes obo:TXPO_0004185c
obo:TXPO_1000512c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001544c
obo:RO_0000086op some obo:TXPO_0000657c

UHRF1 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004203
Super-classes obo:TXPO_1000547c
obo:TXPO_0004185c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000029128c
Sub-classes obo:TXPO_0004855c

TMEM139 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004204
Super-classes obo:TXPO_1000538c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000135932c
obo:RO_0000086op some obo:TXPO_0000657c

TTC39A (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004205
Super-classes obo:TXPO_0004185c
obo:TXPO_1000544c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000022996c

TMEM150C (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004206
Super-classes obo:TXPO_1000539c
obo:TXPO_0004185c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000441027c

lipid metabolism imbalance (severe) [Alcoholic fatty liver]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004207
Super-classes obo:TXPO_0001044c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004209c
obo:TXPO_0000774op only obo:TXPO_0000888c

degree levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004208
Super-classes obo:TXPO_0000288c
Sub-classes obo:TXPO_0001742c
obo:TXPO_0001740c
obo:TXPO_0001743c
obo:TXPO_0002328c
obo:NCIT_C49508c

lipid homeostasis imbalance (severe) [Alcoholic fatty liver]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004209
Super-classes obo:TXPO_0003488c
obo:TXPO_0001038c
Restrictions obo:BFO_0000051op some obo:TXPO_0004207c
obo:TXPO_0000069op some obo:TXPO_0004210c
obo:TXPO_0000774op only obo:TXPO_0000888c
obo:TXPO_0001733op some (obo:TXPO_0000679c or obo:TXPO_0001779c)

lipid accumulation in hepatocyte (severe) [Alcoholic fatty liver]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004210
Super-classes obo:TXPO_0003476c
Restrictions obo:TXPO_0000774op only obo:TXPO_0000888c
obo:BFO_0000051op some obo:TXPO_0001232c
obo:TXPO_0000069op some obo:TXPO_0003480c
obo:TXPO_0000069op some obo:TXPO_0003478c
obo:TXPO_0000069op some obo:TXPO_0003622c
obo:TXPO_0000069op some obo:TXPO_0003512c
obo:TXPO_0001873op some obo:TXPO_0003541c
obo:TXPO_0000069op some obo:TXPO_0003511c
obo:TXPO_0000069op some obo:TXPO_0003495c
obo:TXPO_0000069op some obo:TXPO_0000897c

toxicity (attribute)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004211
Super-classes obo:TXPO_0000305c
Sub-classes obo:TXPO_0004320c

negative regulation of protein-containing complex assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004212
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0065003c
Sub-classes obo:TXPO_0004213c
obo:GO_0031333c

negative regulation of mitochondrial respiratory chain complex assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004213
Super-classes obo:TXPO_0004212c
Restrictions obo:RO_0002212op some obo:GO_0033108c
Sub-classes obo:TXPO_0004216c
obo:TXPO_0004215c
obo:TXPO_0004217c
obo:TXPO_0004225c
obo:TXPO_0004214c

negative regulation of mitochondrial respiratory chain complex I assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004214
Super-classes obo:TXPO_0004213c
Restrictions obo:RO_0002212op some obo:GO_0032981c

negative regulation of mitochondrial respiratory chain complex II assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004215
Super-classes obo:TXPO_0004213c
Restrictions obo:RO_0002212op some obo:GO_0034553c

negative regulation of mitochondrial respiratory chain complex III assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004216
Super-classes obo:TXPO_0004213c
Restrictions obo:RO_0002212op some obo:GO_0034551c

negative regulation of mitochondrial respiratory chain complex IV assemblyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004217
Super-classes obo:TXPO_0004213c
Restrictions obo:RO_0002212op some obo:GO_0033617c
Sub-classes obo:TXPO_0004265c

tumorigenesis [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004218
Super-classes obo:NCIT_C18121c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:RO_0000057op some obo:TXPO_0004318c
obo:RO_0000057op some obo:TXPO_0003610c
obo:RO_0000057op some obo:TXPO_0004319c

ACTA2(mouse) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004219
Super-classes obo:TXPO_0004290c
obo:TXPO_0004226c

CCNB1 (human) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004220
Super-classes obo:TXPO_0004227c
obo:TXPO_0003603c

COL1A1 (mouse) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004221
Super-classes obo:TXPO_0004228c
obo:TXPO_0004226c

GDF15(mouse)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004222
Super-classes obo:TXPO_0004226c
obo:TXPO_1000164c
Sub-classes obo:TXPO_0004223c

GDF15 - inactive form (mouse)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004223
Super-classes obo:TXPO_0004222c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

IL-6 (mouse)[ER stress]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004224
Super-classes obo:IMR_0000010c
obo:TXPO_0004226c

Negative regulation of respiratory complex proteins synthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004225
Super-classes obo:TXPO_0004213c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000051op some obo:TXPO_0004265c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0004125c

mitochondrial damage dependent molecule (mouse)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004226
Super-classes obo:TXPO_0002012c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10090c
Sub-classes obo:TXPO_0004222c
obo:TXPO_0004219c
obo:TXPO_0004221c
obo:TXPO_0004224c

CCNB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004227
Super-classes obo:IMR_0100611c
Sub-classes obo:TXPO_0004220c

COL1A1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004228
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001284c
Sub-classes obo:TXPO_0004221c

CYP2E1 (canonical)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004229
Super-classes obo:TXPO_0004293c
obo:TXPO_1000081c

JNK (canonical)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004230
Super-classes obo:IMR_0000225c
obo:TXPO_1000216c
obo:TXPO_0004293c

DNM1L (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004231
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004232c
obo:TXPO_0004233c

DNM1L(human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004232
Super-classes obo:TXPO_0003603c
obo:TXPO_0004231c

DNM1L(human)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004233
Super-classes obo:TXPO_0004185c
obo:TXPO_0004231c

NEAT1 (predicted) - inactive form (human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004234
Super-classes obo:TXPO_0004177c
Restrictions obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000086op some obo:TXPO_0000657c

TLR9(human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004235
Super-classes obo:TXPO_0003603c
obo:IMR_0001464c
Restrictions obo:RO_0000087op some obo:TXPO_0004296c

TLR9(human)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004236
Super-classes obo:IMR_0001464c
obo:TXPO_0004185c
Restrictions obo:RO_0000087op some obo:TXPO_0004296c

cyclin B1-CDK1 complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004237
Super-classes obo:TXPO_0002107c
Sub-classes obo:TXPO_0004238c

cyclin B1-CDK1 complex (human) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004238
Super-classes obo:TXPO_0003603c
obo:TXPO_0004237c
Restrictions obo:RO_0002180op some obo:TXPO_0003611c
obo:RO_0002180op some obo:TXPO_0004220c
Sub-classes obo:TXPO_0004239c

cyclin B1-CDK1 complex - inactive form (canonical)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004239
Super-classes obo:TXPO_0004238c
obo:TXPO_0003603c
Restrictions obo:RO_0002180op some obo:TXPO_0004220c
obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0002180op some obo:TXPO_0003611c

cyclin B1-CDK1 complex inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004240
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000097c and ub744bL100383C17c)
Sub-classes obo:TXPO_0004241c

cyclin B1-CDK1 complex inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004241
Super-classes obo:TXPO_0001987c
obo:TXPO_0004240c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004375c
obo:RO_0002234op some obo:TXPO_0004239c

ACTA2 production [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004242
Super-classes obo:TXPO_0001987c
obo:TXPO_0004287c
Restrictions obo:RO_0002234op some obo:TXPO_0004219c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004279c

CCL2 production [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004243
Super-classes obo:TXPO_0001987c
obo:TXPO_0004288c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004274c
obo:TXPO_0000069op some obo:TXPO_0004273c
obo:RO_0002234op some obo:TXPO_0003610c

binding to DNA by free radicalsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004244
Super-classes obo:TXPO_0003343c
Sub-classes obo:TXPO_0004308c

COL1A1 production [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004245
Super-classes obo:TXPO_0001987c
obo:TXPO_0004284c
Restrictions obo:RO_0002234op some obo:TXPO_0004221c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004307c

negative regulation of cell cycle G2/M phase transition [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004246
Super-classes obo:TXPO_0001987c
obo:TXPO_0000370c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004376c
obo:TXPO_0000774op only obo:TXPO_0001986c

GDF15 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004247
Super-classes obo:TXPO_0001987c
obo:TXPO_0004248c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004251c
obo:TXPO_0000069op some obo:TXPO_0004268c
obo:RO_0002234op some obo:TXPO_0004223c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:TXPO_0000069op some obo:TXPO_0004252c
obo:TXPO_0000069op some obo:TXPO_0004254c
obo:TXPO_0000069op some obo:TXPO_0004269c
obo:TXPO_0000069op some obo:TXPO_0004245c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004242c
obo:TXPO_0000069op some obo:TXPO_0004266c
obo:TXPO_0000069op some obo:TXPO_0004249c
obo:TXPO_0000069op some obo:TXPO_0004256c

GDF15 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004248
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000164c and ub744bL100567C17c)
Sub-classes obo:TXPO_0004247c

JNK signaling (primitive) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004249
Super-classes obo:TXPO_0000769c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000869c
obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000069op some obo:TXPO_0004279c
obo:TXPO_0000069op some obo:TXPO_0001991c
obo:TXPO_0000069op some obo:TXPO_0004379c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004378c
obo:RO_0000057op some obo:TXPO_0004230c
obo:TXPO_0000069op some obo:TXPO_0004377c

NEAT1 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004250
Super-classes obo:TXPO_0004297c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004260c
obo:TXPO_0000069op some obo:TXPO_0002230c
obo:TXPO_0000069op some obo:TXPO_0004125c
obo:RO_0002234op some obo:TXPO_0004234c
obo:TXPO_0000774op only obo:TXPO_0001986c

NfkB signaling (primitive) [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004251
Super-classes obo:TXPO_0001987c
obo:TXPO_0000761c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000069op some obo:TXPO_0004273c
obo:TXPO_0001868op some obo:IMR_0000382c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004243c
obo:TXPO_0000069op some obo:TXPO_0004279c

p38 signaling (primitive) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004252
Super-classes obo:TXPO_0001987c
obo:TXPO_0004303c
Restrictions obo:RO_0000057op some obo:TXPO_0004292c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004279c
obo:TXPO_0000069op some obo:TXPO_0004271c

TLR9 signaling [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004253
Super-classes obo:TXPO_0001987c
obo:TXPO_0004300c
Restrictions obo:TXPO_0002524op some obo:GO_0034162c
obo:TXPO_0001868op some obo:TXPO_0004235c
obo:TXPO_0000069op some obo:TXPO_0004251c
obo:TXPO_0000069op some obo:TXPO_0004380c
obo:TXPO_0000774op only obo:TXPO_0001986c

tumor necrosis factor production [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004254
Super-classes obo:GO_0032640c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004225c
obo:TXPO_0000069op some obo:TXPO_0004350c
obo:TXPO_0000069op some obo:TXPO_0001879c
obo:TXPO_0000069op some obo:TXPO_0004383c
obo:RO_0002234op some obo:TXPO_0004381c
obo:TXPO_0000069op some obo:TXPO_0004121c
obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000069op some obo:TXPO_0004382c
obo:TXPO_0000774op only obo:TXPO_0001986c

alcohol intake [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004255
Super-classes obo:TXPO_0001987c
obo:TXPO_0001224c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004225c
obo:RO_0002233op some obo:TXPO_0004384c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004121c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:TXPO_0000069op some obo:TXPO_0004383c

interleukin-6 production [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004256
Super-classes obo:TXPO_0001987c
obo:TXPO_0004304c
Restrictions obo:RO_0002234op some obo:TXPO_0004224c
obo:RO_0002234op some obo:TXPO_0004385c
obo:TXPO_0000774op only obo:TXPO_0001986c

binding to mtDNA by radicals [mitochondrial disorder]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004257
Super-classes obo:TXPO_0001987c
obo:TXPO_0004308c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004262c
obo:TXPO_0000774op only obo:TXPO_0001986c

increasing free radical [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004258
Super-classes obo:TXPO_0001790c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004257c
obo:TXPO_0000069op some obo:TXPO_0004278c

release of DNA from mitochondria [mitochondria disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004259
Super-classes obo:TXPO_0001863c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004253c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0004218c
obo:RO_0002234op only efo:EFO_0008480c

decreasing mtDNA level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004260
Super-classes obo:TXPO_0004310c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004365c
obo:TXPO_0000069op some obo:TXPO_0002005c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0000057op some obo:TXPO_0004387c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:RO_0000057op some obo:TXPO_0004386c
obo:RO_0000057op some obo:TXPO_0004388c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:RO_0000057op some obo:TXPO_0004389c
obo:RO_0000057op some obo:TXPO_0004337c
obo:TXPO_0000069op some obo:TXPO_0004281c
obo:RO_0000057op some obo:TXPO_0004335c
obo:RO_0000057op some obo:TXPO_0004331c
obo:TXPO_0000069op some obo:TXPO_0000933c

mitochondria fission [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004261
Super-classes obo:TXPO_0001987c
obo:GO_0000266c
Restrictions obo:RO_0002233op only obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0004259c
obo:TXPO_0000069op some obo:TXPO_0001992c
obo:TXPO_0000069op some obo:TXPO_0002230c
obo:RO_0002234op only obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op only obo:GO_0005739c

mitochondrial DNA catabolic process [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004262
Super-classes obo:GO_0032043c
obo:TXPO_0001987c
Restrictions obo:RO_0002233op only efo:EFO_0008480c
obo:TXPO_0000774op only obo:TXPO_0001986c

release of cytochrome c from mitochondria [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004263
Super-classes obo:TXPO_0001987c
obo:GO_0001836c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001992c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0000869c

metabolic dysfunction of precursor metabolites and energy generation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004264
Super-classes obo:TXPO_0001987c
obo:TXPO_0004305c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001029c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001992c
obo:TXPO_0000069op some obo:TXPO_0004246c

Negative regulation of respiratory complex IV proteins synthesis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004265
Super-classes obo:TXPO_0001987c
obo:TXPO_0004217c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004125c
obo:BFO_0000066op some obo:GO_0005739c
obo:RO_0000057op some obo:TXPO_0004316c

monocyte migration [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004266
Super-classes obo:TXPO_0001987c
obo:TXPO_0004313c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000069op some obo:TXPO_0004279c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002339op some obo:UBERON_0002107c

increasing uptake amount of mitochondrial calcium ion [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004267
Super-classes obo:TXPO_0002229c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001993c

neutrophil migration [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004268
Super-classes obo:TXPO_0004315c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004271c
obo:RO_0002339op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004279c

cytokine production involved in inflammatory response [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004269
Super-classes obo:TXPO_0001987c
obo:GO_0002534c
Restrictions obo:BFO_0000066op some obo:CL_0000235c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004271c

inflammatory cytokine gene expression [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004270
Super-classes obo:TXPO_0001987c
obo:TXPO_0002266c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000051op some obo:TXPO_0004270c
obo:TXPO_0000069op some obo:TXPO_0004271c

Inflammatory response [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004271
Super-classes obo:TXPO_0000192c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004316c
obo:TXPO_0000069op some obo:TXPO_0004379c
obo:TXPO_0000069op some obo:TXPO_0004281c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0004279c
obo:TXPO_0000069op some obo:TXPO_0004218c
obo:TXPO_0000069op some obo:TXPO_0004390c

cellular damage [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004272
Super-classes obo:TXPO_0001987c
obo:TXPO_0000225c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004279c
obo:TXPO_0000069op some obo:TXPO_0004218c
obo:TXPO_0000069op some obo:TXPO_0004281c
obo:TXPO_0000774op only obo:TXPO_0001986c

Tumor-associated macrophage activation[Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004273
Super-classes obo:TXPO_0001987c
obo:TXPO_0004277c
Restrictions obo:RO_0002233op only obo:NCIT_C116387c
obo:TXPO_0000069op some obo:TXPO_0004218c
obo:TXPO_0001868op some obo:TXPO_0003610c
obo:TXPO_0000069op some obo:TXPO_0004324c
obo:TXPO_0000774op only obo:TXPO_0001986c

tumor-associated macrophage migration [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004274
Super-classes obo:TXPO_0004275c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

tumor-associated macrophage migrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004275
Super-classes obo:GO_1905517c
Sub-classes obo:TXPO_0004274c

Tumor-associated macrophage activation@hepatocarcinogenesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004276
Super-classes obo:TXPO_0004277c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004391c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0002233op only obo:NCIT_C116387c
obo:TXPO_0000774op only obo:TXPO_0004280c

Tumor-associated macrophage activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004277
Super-classes obo:GO_0042116c
Sub-classes obo:TXPO_0004276c
obo:TXPO_0004273c

lipoperoxidation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004278
Super-classes obo:TXPO_0003514c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004262c
obo:TXPO_0000069op some obo:TXPO_0004324c
obo:TXPO_0000069op some obo:TXPO_0004393c
obo:TXPO_0000069op some obo:TXPO_0004269c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004121c

hepatic fibrosis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004279
Super-classes obo:TXPO_0000816c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004316c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0001986c

hepatocarcinogenesis [toxic course]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004280
Description

under construction
Super-classes obo:TXPO_0000009c
Restrictions obo:BFO_0000051op some obo:TXPO_0004400c
obo:BFO_0000051op some obo:TXPO_0004996c
obo:BFO_0000051op some obo:TXPO_0004417c
obo:BFO_0000051op some obo:TXPO_0004586c
obo:BFO_0000051op some obo:TXPO_0004659c
obo:BFO_0000051op some obo:TXPO_0004587c
obo:BFO_0000051op some obo:TXPO_0004728c
obo:BFO_0000051op some obo:TXPO_0004309c
obo:BFO_0000051op some obo:TXPO_0004681c
obo:BFO_0000051op some obo:TXPO_0004793c
obo:BFO_0000051op some obo:TXPO_0004536c
obo:BFO_0000051op some obo:TXPO_0004546c
obo:BFO_0000051op some obo:TXPO_0004800c
obo:BFO_0000051op some obo:TXPO_0005014c
obo:BFO_0000051op some obo:TXPO_0004679c
obo:BFO_0000051op some obo:TXPO_0004686c
obo:BFO_0000051op some obo:TXPO_0004901c
obo:BFO_0000051op some obo:TXPO_0004693c
obo:BFO_0000051op some obo:TXPO_0004787c
obo:BFO_0000051op some obo:TXPO_0004949c
obo:BFO_0000051op some obo:TXPO_0004592c
obo:BFO_0000051op some obo:TXPO_0004758c
obo:BFO_0000051op some obo:TXPO_0004919c
obo:BFO_0000051op some obo:TXPO_0004828c
obo:BFO_0000051op some obo:TXPO_0004579c
obo:BFO_0000051op some obo:TXPO_0004595c
obo:BFO_0000051op some obo:TXPO_0005035c
obo:BFO_0000051op some obo:TXPO_0004963c
obo:BFO_0000051op some obo:TXPO_0005038c
obo:BFO_0000051op some obo:TXPO_0004483c
obo:BFO_0000051op some obo:TXPO_0004683c
obo:BFO_0000051op some obo:TXPO_0004418c
obo:BFO_0000051op some obo:TXPO_0004412c
obo:BFO_0000051op some obo:TXPO_0004289c
obo:BFO_0000051op some obo:TXPO_0004664c
obo:BFO_0000051op some obo:TXPO_0005017c
obo:BFO_0000051op some obo:TXPO_0004426c
obo:BFO_0000051op some obo:TXPO_0004603c
obo:BFO_0000051op some obo:TXPO_0004517c
obo:BFO_0000051op some obo:TXPO_0004480c
obo:BFO_0000051op some obo:TXPO_0005026c
obo:BFO_0000051op some obo:TXPO_0004625c
obo:BFO_0000051op some obo:TXPO_0004598c
obo:BFO_0000051op some obo:TXPO_0004522c
obo:BFO_0000051op some obo:TXPO_0004755c
obo:BFO_0000051op some obo:TXPO_0004825c
obo:BFO_0000051op some obo:TXPO_0004929c
obo:BFO_0000051op some obo:TXPO_0004844c
obo:BFO_0000051op some obo:TXPO_0004582c
obo:BFO_0000051op some obo:TXPO_0004507c
obo:BFO_0000051op some obo:TXPO_0004633c
obo:BFO_0000051op some obo:TXPO_0004298c
obo:BFO_0000051op some obo:TXPO_0004776c
obo:BFO_0000051op some obo:TXPO_0004883c
obo:BFO_0000051op some obo:TXPO_0004459c
obo:BFO_0000051op some obo:TXPO_0004505c
obo:BFO_0000051op some obo:TXPO_0004874c
obo:BFO_0000051op some obo:TXPO_0004640c
obo:BFO_0000051op some obo:TXPO_0004764c
obo:BFO_0000051op some obo:TXPO_0004908c
obo:BFO_0000051op some obo:TXPO_0004588c
obo:BFO_0000051op some obo:TXPO_0004432c
obo:BFO_0000051op some obo:TXPO_0005032c
obo:BFO_0000051op some obo:TXPO_0004476c
obo:BFO_0000051op some obo:TXPO_0004529c
obo:BFO_0000051op some obo:TXPO_0005036c
obo:BFO_0000051op some obo:TXPO_0004854c
obo:BFO_0000051op some obo:TXPO_0004438c
obo:BFO_0000051op some obo:TXPO_0004596c
obo:BFO_0000051op some obo:TXPO_0004526c
obo:BFO_0000051op some obo:TXPO_0004396c
obo:BFO_0000051op some obo:TXPO_0004923c
obo:BFO_0000051op some obo:TXPO_0004650c
obo:BFO_0000051op some obo:TXPO_0004404c
obo:BFO_0000051op some obo:TXPO_0004525c
obo:BFO_0000051op some obo:TXPO_0004452c
obo:BFO_0000051op some obo:TXPO_0004834c
obo:BFO_0000051op some obo:TXPO_0004422c
obo:BFO_0000051op some obo:TXPO_0004673c
obo:BFO_0000051op some obo:TXPO_0004492c
obo:BFO_0000051op some obo:TXPO_0004421c
obo:BFO_0000051op some obo:TXPO_0004655c
obo:BFO_0000051op some obo:TXPO_0004311c
obo:BFO_0000051op some obo:TXPO_0004434c
obo:BFO_0000051op some obo:TXPO_0004489c
obo:BFO_0000051op some obo:TXPO_0004597c
obo:BFO_0000051op some obo:TXPO_0004634c
obo:BFO_0000051op some obo:TXPO_0004457c
obo:BFO_0000051op some obo:TXPO_0004616c
obo:BFO_0000051op some obo:TXPO_0004847c
obo:BFO_0000051op some obo:TXPO_0004745c
obo:BFO_0000051op some obo:TXPO_0004491c
obo:BFO_0000051op some obo:TXPO_0004410c
obo:BFO_0000051op some obo:TXPO_0004882c
obo:BFO_0000051op some obo:TXPO_0004881c
obo:BFO_0000051op some obo:TXPO_0004557c
obo:BFO_0000051op some obo:TXPO_0004609c
obo:BFO_0000051op some obo:TXPO_0004661c
obo:BFO_0000051op some obo:TXPO_0004698c
obo:BFO_0000051op some obo:TXPO_0004791c
obo:BFO_0000051op some obo:TXPO_0004391c
obo:BFO_0000051op some obo:TXPO_0004600c
obo:BFO_0000051op some obo:TXPO_0004402c
obo:BFO_0000051op some obo:TXPO_0004695c
obo:BFO_0000051op some obo:TXPO_0004703c
obo:BFO_0000051op some obo:TXPO_0004464c
obo:BFO_0000051op some obo:TXPO_0004574c
obo:BFO_0000051op some obo:TXPO_0004759c
obo:BFO_0000051op some obo:TXPO_0004420c
obo:BFO_0000051op some obo:TXPO_0004783c
obo:BFO_0000051op some obo:TXPO_0004414c
obo:BFO_0000051op some obo:TXPO_0004577c
obo:BFO_0000051op some obo:TXPO_0004952c
obo:BFO_0000051op some obo:TXPO_0004538c
obo:BFO_0000051op some obo:TXPO_0005005c
obo:BFO_0000051op some obo:TXPO_0004453c
obo:BFO_0000051op some obo:TXPO_0004299c
obo:BFO_0000051op some obo:TXPO_0004543c
obo:BFO_0000051op some obo:TXPO_0004646c
obo:BFO_0000051op some obo:TXPO_0004617c
obo:BFO_0000051op some obo:TXPO_0004593c
obo:BFO_0000051op some obo:TXPO_0004392c
obo:BFO_0000051op some obo:TXPO_0004630c
obo:BFO_0000051op some obo:TXPO_0004395c
obo:BFO_0000051op some obo:TXPO_0004779c
obo:BFO_0000051op some obo:TXPO_0004479c
obo:BFO_0000051op some obo:TXPO_0004636c
obo:BFO_0000051op some obo:TXPO_0004501c
obo:BFO_0000051op some obo:TXPO_0004803c
obo:BFO_0000051op some obo:TXPO_0004566c
obo:BFO_0000051op some obo:TXPO_0005022c
obo:BFO_0000051op some obo:TXPO_0004753c
obo:BFO_0000051op some obo:TXPO_0004413c
obo:BFO_0000051op some obo:TXPO_0004487c
obo:BFO_0000051op some obo:TXPO_0004394c
obo:BFO_0000051op some obo:TXPO_0004841c
obo:BFO_0000051op some obo:TXPO_0004468c
obo:BFO_0000051op some obo:TXPO_0004506c
obo:BFO_0000051op some obo:TXPO_0004749c
obo:BFO_0000051op some obo:TXPO_0004427c
obo:BFO_0000051op some obo:TXPO_0004276c
obo:BFO_0000051op some obo:TXPO_0004731c
obo:BFO_0000051op some obo:TXPO_0004837c
obo:BFO_0000051op some obo:TXPO_0004409c
obo:BFO_0000051op some obo:TXPO_0004403c
obo:BFO_0000051op some obo:TXPO_0004447c
obo:BFO_0000051op some obo:TXPO_0004757c
obo:BFO_0000051op some obo:TXPO_0005051c
obo:BFO_0000051op some obo:TXPO_0004497c
obo:BFO_0000051op some obo:TXPO_0004818c
obo:BFO_0000051op some obo:TXPO_0004652c
obo:BFO_0000051op some obo:TXPO_0004845c
obo:BFO_0000051op some obo:TXPO_0004589c
obo:BFO_0000051op some obo:TXPO_0005010c
obo:BFO_0000051op some obo:TXPO_0004899c
obo:BFO_0000051op some obo:TXPO_0004555c
obo:BFO_0000051op some obo:TXPO_0004407c
obo:BFO_0000051op some obo:TXPO_0004542c
obo:BFO_0000051op some obo:TXPO_0004570c
obo:BFO_0000051op some obo:TXPO_0004512c
obo:BFO_0000051op some obo:TXPO_0004590c
obo:BFO_0000051op some obo:TXPO_0004585c
obo:BFO_0000051op some obo:TXPO_0004735c
obo:BFO_0000051op some obo:TXPO_0004429c
obo:BFO_0000051op some obo:TXPO_0004591c
obo:BFO_0000051op some obo:TXPO_0004738c
obo:BFO_0000051op some obo:TXPO_0004789c
obo:BFO_0000051op some obo:TXPO_0004816c
obo:BFO_0000051op some obo:TXPO_0004643c
obo:BFO_0000051op some obo:TXPO_0004518c
obo:BFO_0000051op some obo:TXPO_0004514c
obo:BFO_0000051op some obo:TXPO_0004541c
obo:BFO_0000051op some obo:TXPO_0004431c
obo:BFO_0000051op some obo:TXPO_0004470c
obo:BFO_0000051op some obo:TXPO_0004477c
obo:BFO_0000051op some obo:TXPO_0004508c
obo:BFO_0000051op some obo:TXPO_0004809c
obo:BFO_0000051op some obo:TXPO_0005019c
obo:BFO_0000051op some obo:TXPO_0004773c
obo:BFO_0000051op some obo:TXPO_0004689c
obo:BFO_0000051op some obo:TXPO_0004627c
obo:BFO_0000051op some obo:TXPO_0004669c
obo:BFO_0000051op some obo:TXPO_0004419c
obo:BFO_0000051op some obo:TXPO_0004794c
obo:BFO_0000051op some obo:TXPO_0004656c

liver malfunction [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004281
Super-classes obo:TXPO_0002074c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

Scleroprotein productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004282
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0004283c

Collagen productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004283
Super-classes obo:TXPO_0004282c
Sub-classes obo:TXPO_0004284c

COL1A1 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004284
Super-classes obo:TXPO_0004283c
Sub-classes obo:TXPO_0004245c

cytoskeletal protein productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004285
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0004286c

actin productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004286
Super-classes obo:TXPO_0004285c
Sub-classes obo:TXPO_0004287c

ACTA2 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004287
Super-classes obo:TXPO_0004286c
Sub-classes obo:TXPO_0004242c

chemokine (C-C motif) ligand 2 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004288
Super-classes obo:GO_0032602c
Sub-classes obo:TXPO_0004243c
obo:TXPO_0004289c

CCL2 production [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004289
Super-classes obo:TXPO_0002340c
obo:TXPO_0004288c
Restrictions obo:RO_0002234op some obo:TXPO_0004291c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004299c

ACTA2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004290
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006347c
Sub-classes obo:TXPO_0004219c

CCL2(human)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004291
Super-classes obo:TXPO_0004185c
obo:TXPO_1000086c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006347c

p38(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004292
Super-classes obo:IMR_0000226c
obo:TXPO_0004293c

mitochondrial damage dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004293
Super-classes obo:TXPO_0002012c
Sub-classes obo:TXPO_0005125c
obo:TXPO_0004552c
obo:TXPO_0005066c
obo:TXPO_0004721c
obo:TXPO_0004385c
obo:TXPO_0004229c
obo:TXPO_0004474c
obo:TXPO_0004381c
obo:TXPO_0004648c
obo:TXPO_0004357c
obo:TXPO_0004230c
obo:TXPO_0004292c
obo:TXPO_0005120c
obo:TXPO_0004356c
obo:TXPO_0005090c
obo:TXPO_0004355c
obo:TXPO_0004885c
obo:TXPO_0004831c
obo:TXPO_0004822c

carbon tetrachloride metabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004294
Super-classes obo:GO_0006805c
Sub-classes obo:TXPO_0004295c

carbon tetrachloride metabolic process [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004295
Super-classes obo:TXPO_0004294c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004258c
obo:RO_0002234op some obo:TXPO_0004317c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002233op only obo:TXPO_0004316c
obo:TXPO_0001868op some obo:TXPO_0004229c

DNA sensorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004296
Super-classes obo:TXPO_0000882c

NEAT1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004297
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000521c and ub744bL102278C17c)
Sub-classes obo:TXPO_0004250c

NfkB signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004298
Super-classes obo:TXPO_0002340c
obo:TXPO_0000761c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004394c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004276c
obo:RO_0000057op some obo:IMR_0000382c
obo:TXPO_0000069op some obo:TXPO_0004395c

TLR9 signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004299
Super-classes obo:TXPO_0002340c
obo:TXPO_0004300c
Restrictions obo:TXPO_0001868op some obo:TXPO_0004236c
obo:TXPO_0000069op some obo:TXPO_0004298c
obo:TXPO_0002524op some obo:GO_0034162c

TLR9 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004300
Super-classes obo:TXPO_0004301c
Restrictions obo:TXPO_0001868op some obo:IMR_0001464c
obo:TXPO_0002524op some obo:GO_0034162c
Sub-classes obo:TXPO_0004253c
obo:TXPO_0004299c

TLR signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004301
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0001868op some obo:IMR_0001464c
obo:TXPO_0002524op some obo:GO_0002224c
Sub-classes obo:TXPO_0004300c
obo:TXPO_0004829c

p38 signaling cascadec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004302
Super-classes obo:TXPO_0000609c
Restrictions obo:BFO_0000051op some obo:TXPO_0000769c

p38 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004303
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004302c
Sub-classes obo:TXPO_0004252c
obo:TXPO_0004420c

interleukin-6 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004304
Super-classes obo:GO_0001816c
Sub-classes obo:TXPO_0004256c

metabolic dysfunction of precursor metabolites and energy generationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004305
Super-classes obo:TXPO_0002131c
Restrictions obo:RO_0002233op only obo:GO_0006091c
Sub-classes obo:TXPO_0004264c

collagen depositionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004306
Super-classes obo:TXPO_0000247c
Sub-classes obo:TXPO_0004307c

collagen deposition [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004307
Super-classes obo:TXPO_0004306c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004279c
obo:TXPO_0000774op only obo:TXPO_0001986c

binding to mtDNA by radicalsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004308
Super-classes obo:TXPO_0004244c
Sub-classes obo:TXPO_0004257c

release of DNA from mitochondria [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004309
Super-classes obo:TXPO_0002340c
obo:TXPO_0001863c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0004289c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op only efo:EFO_0008480c

decreasing mtDNA levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004310
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0004260c

mitochondrial fission [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004311
Super-classes obo:TXPO_0002340c
obo:GO_0000266c
Restrictions obo:RO_0002234op only obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op only obo:GO_0005739c
obo:TXPO_0001868op some obo:TXPO_0004233c
obo:TXPO_0000069op some obo:TXPO_0004309c
obo:BFO_0000066op only obo:GO_0005739c

mitochondria disorder dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004312
Super-classes obo:TXPO_0002012c
Sub-classes obo:TXPO_0004317c
obo:TXPO_0004338c
obo:TXPO_0004336c
obo:TXPO_0004363c
obo:TXPO_0004365c
obo:TXPO_0004331c
obo:TXPO_0004386c
obo:TXPO_0004362c
obo:TXPO_0004352c
obo:TXPO_0005058c
obo:TXPO_0004332c
obo:TXPO_0004334c
obo:TXPO_0004333c
obo:TXPO_0004979c
obo:TXPO_0004358c
obo:TXPO_0004337c
obo:TXPO_0004316c
obo:TXPO_0004330c
obo:TXPO_0004361c
obo:TXPO_0004339c
obo:TXPO_0004364c
obo:TXPO_0004354c
obo:TXPO_0004353c
obo:TXPO_0004335c
obo:TXPO_0004384c
obo:TXPO_0005025c
obo:TXPO_0004387c
obo:TXPO_0004389c
obo:TXPO_0004388c

monocyte migrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004313
Super-classes obo:GO_0050900c
Sub-classes obo:TXPO_0004266c

respiratory chain inhibitor rolec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004314
Super-classes obo:TXPO_0004023c

neutrophil migrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004315
Super-classes obo:GO_0050900c
Sub-classes obo:TXPO_0004268c

CCL4 [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004316
Super-classes obo:CHEBI_27385c
obo:TXPO_0004312c
Restrictions obo:RO_0000087op some obo:TXPO_0002250c
obo:RO_0000087op some obo:TXPO_0003572c
obo:RO_0000087op some obo:TXPO_0004314c

radicals [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004317
Super-classes obo:TXPO_0004312c
obo:CHEBI_26519c

STAT3(human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004318
Super-classes obo:TXPO_0003603c
obo:IMR_0000377c
Restrictions obo:RO_0000087op some obo:TXPO_0003724c

IL-6(human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004319
Super-classes obo:TXPO_0003603c
obo:IMR_0000010c
Restrictions obo:RO_0000087op some obo:TXPO_0003724c

drug toxicityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004320
Super-classes obo:TXPO_0004211c
Sub-classes obo:TXPO_0004321c

drug liver toxicityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004321
Super-classes obo:TXPO_0004320c

toxicity valuec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004322
Super-classes obo:TXPO_0000277c
Sub-classes obo:TXPO_0005142c
obo:TXPO_0005140c
obo:TXPO_0004323c

Most-DILI-Concernc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004323
Description

From Drug Induced Liver Injury Rank (DILIrank) Dataset. DILIrank consists of 1,036 FDA-approved drugs that are divided into four classes according to their potential for causing drug-induced liver injury (DILI).
Super-classes obo:TXPO_0004322c

IL6 signaling [Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004324
Super-classes obo:TXPO_0004327c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004319c
obo:RO_0000057op some obo:TXPO_0004385c
obo:TXPO_0000069op some obo:TXPO_0004397c
obo:BFO_0000051op some obo:TXPO_0004256c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004325c
obo:TXPO_0000069op some obo:TXPO_0002041c
obo:TXPO_0002524op some obo:GO_0070102c
obo:TXPO_0000069op some obo:TXPO_0004271c

STAT3 activation[Mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004325
Super-classes obo:TXPO_0004326c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004218c
obo:RO_0002233op some obo:TXPO_0004318c
obo:TXPO_0000774op only obo:TXPO_0001986c

STAT3 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004326
Super-classes obo:TXPO_0000023c
Restrictions obo:TXPO_0000069op some obo:TXPO_0003113c
obo:TXPO_0000774op only obo:TXPO_0002528c
Sub-classes obo:TXPO_0004325c
obo:TXPO_0004787c

IL-6 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004327
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0070102c
Sub-classes obo:TXPO_0004659c
obo:TXPO_0004324c

reactive aldehydec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004328
Super-classes obo:CHEBI_17478c
Sub-classes obo:CHEBI_142593c
obo:CHEBI_566274c
obo:TXPO_0005024c

mitochondrial respiratory chain complex I subunitc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004329
Super-classes obo:GO_0098800c
Restrictions obo:BFO_0000050op only obo:GO_0005747c

perhexiline [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004330
Super-classes obo:CHEBI_35553c
obo:TXPO_0004312c

Acetaminophen [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004331
Super-classes obo:TXPO_0004312c
obo:CHEBI_46195c

amiodarone [mitochondrial disorder]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004332
Super-classes obo:CHEBI_2663c
obo:TXPO_0004312c

alpidem [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004333
Super-classes obo:CHEBI_135649c
obo:TXPO_0004312c

disulfiram [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004334
Super-classes obo:TXPO_0004312c
obo:CHEBI_4659c

tamoxifen [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004335
Super-classes obo:TXPO_0004312c
obo:CHEBI_41774c
Restrictions obo:RO_0000087op some obo:TXPO_0001426c

tetracycline [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004336
Super-classes obo:TXPO_0004312c
obo:CHEBI_27902c

troglitazone [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004337
Description

Rifampicin, bosentan, and troglitazone directly inhibit bile salt export pump (BSEP).
Super-classes obo:TXPO_0004312c
obo:CHEBI_9753c
Restrictions obo:RO_0000087op some obo:TXPO_0001866c

nilutamide [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004338
Super-classes obo:TXPO_0004312c
obo:CHEBI_7573c

buprenorphine [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004339
Super-classes obo:CHEBI_3216c
obo:TXPO_0004312c

increasing demand for response to ER stress [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004340
Super-classes obo:TXPO_0000362c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004218c

cardiolipin peroxidation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004341
Description

PMID:25339807
Super-classes obo:TXPO_0004931c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004436c
obo:RO_0002233op some obo:CHEBI_28494c
obo:TXPO_0000069op some obo:TXPO_0004263c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001991c

necrosis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004342
Super-classes obo:GO_0070265c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0003568c

cellular membrane lipoperoxidation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004343
Super-classes obo:TXPO_0003513c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

hepatic stellate cell activation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004344
Super-classes obo:TXPO_0001987c
obo:GO_0035733c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004279c
obo:TXPO_0000774op only obo:TXPO_0001986c

mitochondrial membrane morphology changes [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004345
Super-classes obo:TXPO_0004998c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

IL-1beta production [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004346
Super-classes obo:GO_0032611c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002234op some obo:TXPO_0004648c
obo:TXPO_0000069op some obo:TXPO_0004271c

Insulin resistance (process) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004347
Super-classes obo:TXPO_0002189c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0002004c

Calcium ion homeostasis imbalance [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004348
Super-classes obo:TXPO_0001987c
obo:TXPO_0001765c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

Hypofunction of sequestering of calcium ion in ER [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004349
Super-classes obo:TXPO_0001987c
obo:TXPO_0002192c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op some obo:GO_0005783c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:TXPO_0000069op some obo:TXPO_0001992c

mitochondria morphology change [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004350
Super-classes obo:TXPO_0001987c
obo:TXPO_0004888c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000933c
obo:RO_0002233op only obo:GO_0005739c
obo:TXPO_0000774op only obo:TXPO_0001986c

redox changes [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004351
Super-classes obo:TXPO_0005011c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002230c
obo:TXPO_0000069op some obo:TXPO_0004373c
obo:TXPO_0000774op only obo:TXPO_0001986c

salicylic acid [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004352
Super-classes obo:TXPO_0004312c
obo:CHEBI_16914c

diclofenac [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004353
Super-classes obo:CHEBI_47381c
obo:TXPO_0004312c

nimesulide [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004354
Super-classes obo:CHEBI_44445c
obo:TXPO_0004312c

BAK1(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004355
Super-classes obo:TXPO_1000040c
obo:TXPO_0004293c

BAX(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004356
Super-classes obo:IMR_0000453c
obo:TXPO_0004293c
Restrictions obo:RO_0000087op some obo:TXPO_0000327c

BID(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004357
Super-classes obo:IMR_0100289c
obo:TXPO_0004293c

valproic acid [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004358
Super-classes obo:CHEBI_39867c
obo:TXPO_0004312c

nagative regulation of mitophagy [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004359
Super-classes obo:TXPO_0001987c
obo:TXPO_0004977c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002040c
obo:TXPO_0000069op some obo:TXPO_0004368c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004340c
obo:TXPO_0000069op some obo:TXPO_0004978c
obo:RO_0002213op some obo:GO_0000423c

mitochondrial fatty acid beta-oxidation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004360
Super-classes obo:TXPO_0001987c
obo:TXPO_0001388c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001990c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004127c

amineptine [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004361
Super-classes obo:TXPO_0004312c
obo:CHEBI_32499c

ibuprofen [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004362
Super-classes obo:CHEBI_5855c
obo:TXPO_0004312c

panadiplon [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004363
Super-classes obo:TXPO_0004312c
obo:TXPO_0004970c

pirprofen [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004364
Super-classes obo:CHEBI_135028c
obo:TXPO_0004312c

tacrine [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004365
Super-classes obo:TXPO_0004312c
obo:CHEBI_45980c

hyperfunction of CYP2E1 gene expression [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004366
Super-classes obo:TXPO_0001987c
obo:TXPO_0004493c
Restrictions obo:RO_0002234op some obo:TXPO_0004229c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001990c

hyperfunction of gluconeogenesis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004367
Super-classes obo:TXPO_0004942c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0001502op some obo:GO_0006094c
obo:TXPO_0000069op some obo:TXPO_0004937c

Increasing damaged mitochondria [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004368
Super-classes obo:TXPO_0001987c
obo:TXPO_0005030c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002005c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:TXPO_0000069op some obo:TXPO_0004342c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004263c
obo:TXPO_0000069op some obo:TXPO_0005031c

increasing CPT1 level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004369
Super-classes obo:TXPO_0004473c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004360c
obo:RO_0002234op some obo:TXPO_0004474c

hypofunction of anti-oxidative stress[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004370
Super-classes obo:TXPO_0001987c
obo:TXPO_0004066c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004373c

gluconeogenesis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004371
Super-classes obo:TXPO_0001987c
obo:GO_0016051c
Restrictions obo:TXPO_0000069op some obo:TXPO_0005034c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002234op some obo:CHEBI_17234c

lipid biosynthetic process [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004372
Super-classes obo:GO_0008610c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0005039c
obo:BFO_0000066op some obo:UBERON_0002107c

increasing demand for response to oxidative stress [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004373
Super-classes obo:TXPO_0001987c
obo:TXPO_0000102c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004272c
obo:TXPO_0000069op some obo:TXPO_0001991c
obo:TXPO_0000069op some obo:TXPO_0004121c
obo:TXPO_0000069op some obo:TXPO_0004349c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004348c
obo:TXPO_0000069op some obo:TXPO_0004390c

ketone body biosynthetic process [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004374
Super-classes obo:GO_0046951c
obo:TXPO_0001987c
Restrictions obo:RO_0002234op some obo:CHEBI_73693c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004946c

Negative regulation of mitochondrial respiratory chain complex I subunit phosphorylation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004375
Super-classes obo:TXPO_0001987c
obo:TXPO_0004993c
Restrictions obo:RO_0002212op some obo:TXPO_0004995c
obo:TXPO_0000069op some obo:TXPO_0004125c
obo:TXPO_0000774op only obo:TXPO_0001986c

cell cycle arrest [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004376
Super-classes obo:TXPO_0001987c
obo:GO_0007050c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

Increasing HMGB1 level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004377
Super-classes obo:TXPO_0001987c
obo:TXPO_0004618c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001992c
obo:RO_0002234op some obo:TXPO_0004619c
obo:TXPO_0000069op some obo:TXPO_0004342c

TLR4 signaling [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004378
Super-classes obo:TXPO_0004829c
obo:TXPO_0001987c
Restrictions obo:TXPO_0002524op some obo:GO_0034142c
obo:TXPO_0000069op some obo:TXPO_0004830c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0001868op some obo:TXPO_0004831c

Malfunctioning of insulin signaling [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004379
Super-classes obo:TXPO_0001987c
obo:TXPO_0001125c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004347c
obo:TXPO_0000774op only obo:TXPO_0001986c

inflammasome activation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004380
Super-classes obo:TXPO_0001987c
obo:TXPO_0001107c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004271c
obo:RO_0000057op some obo:TXPO_0004925c

TNFΑ (canonical)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004381
Super-classes obo:TXPO_0004293c
obo:TXPO_1000374c

HIF1A activation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004382
Super-classes obo:TXPO_0001987c
obo:TXPO_0004612c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:RO_0002234op some obo:TXPO_0004614c

inducible nitric oxide synthase production [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004383
Super-classes obo:TXPO_0004884c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004717c
obo:RO_0002234op some obo:TXPO_0004885c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004718c

alcohol [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004384
Super-classes obo:CHEBI_30879c
obo:TXPO_0004312c

IL-6(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004385
Super-classes obo:TXPO_0004293c
obo:IMR_0000010c

didanosine [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004386
Super-classes obo:TXPO_0004312c
obo:CHEBI_490877c

zidovudine [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004387
Super-classes obo:CHEBI_10110c
obo:TXPO_0004312c

stavudine [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004388
Super-classes obo:CHEBI_63581c
obo:TXPO_0004312c

fialuridine [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004389
Super-classes obo:TXPO_0004972c
obo:TXPO_0004312c

Hypofunction of PPARGC1A gene expression [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004390
Super-classes obo:TXPO_0001987c
obo:TXPO_0004768c
Restrictions obo:RO_0000057op some obo:TXPO_0004769c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004225c

Increasing IL-6 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004391
Super-classes obo:TXPO_0004653c
obo:TXPO_0002340c
Restrictions obo:RO_0002234op some obo:TXPO_0004654c
obo:TXPO_0000069op some obo:TXPO_0004655c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:NCIT_C116387c

tumorigenesis [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004392
Super-classes obo:TXPO_0002340c
obo:NCIT_C18121c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004513c
obo:RO_0000057op some obo:TXPO_0004448c
obo:RO_0000057op some obo:TXPO_0005060c
obo:RO_0000057op some obo:TXPO_0005138c
obo:RO_0000057op some obo:TXPO_0004948c
obo:RO_0000057op some obo:TXPO_0004907c
obo:RO_0000057op some obo:TXPO_0004934c
obo:RO_0000057op some obo:TXPO_0004971c
obo:RO_0000057op some obo:TXPO_0005062c
obo:RO_0000057op some obo:TXPO_0004704c
obo:RO_0000057op some obo:TXPO_0005008c
obo:RO_0000057op some obo:TXPO_0004924c
obo:RO_0000057op some obo:TXPO_0004961c
obo:RO_0000057op some obo:TXPO_0004922c
obo:BFO_0000066op some obo:UBERON_0002107c

increasing production amount of reactive aldehyde [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004393
Super-classes obo:TXPO_0005023c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000869c
obo:RO_0002234op some obo:TXPO_0004979c
obo:RO_0002234op some obo:TXPO_0005024c
obo:RO_0002234op some obo:TXPO_0005025c
obo:TXPO_0000774op only obo:TXPO_0001986c

chemokine (C-X-C motif) ligand 8 production [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004394
Super-classes obo:TXPO_0002340c
obo:TXPO_0004478c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004438c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:TXPO_0000069op some obo:TXPO_0004413c
obo:RO_0002234op some obo:TXPO_0004198c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000774op only obo:TXPO_0004280c

Snail1 signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004395
Super-classes obo:TXPO_0004810c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004812c
obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000069op some obo:TXPO_0004779c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c

negative regulation of apoptotic process [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004396
Super-classes obo:GO_0043066c
obo:TXPO_0002340c
Restrictions obo:BFO_0000051op some obo:TXPO_0004764c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004919c
obo:RO_0000057op some obo:TXPO_0004918c
obo:RO_0000057op some obo:TXPO_0004917c

Iron accumulation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004397
Super-classes obo:TXPO_0001987c
obo:TXPO_0003182c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002233op some obo:CHEBI_18248c
obo:TXPO_0000069op some obo:TXPO_0004373c

Increasing ACSL1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004398
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004399c
Sub-classes obo:TXPO_0004400c

ACSL1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004399
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004401c

Increasing ACSL1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004400
Super-classes obo:TXPO_0002340c
obo:TXPO_0004398c
Restrictions obo:RO_0002234op some obo:TXPO_0004401c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000069op some obo:TXPO_0004403c
obo:TXPO_0000069op some obo:TXPO_0004402c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004396c

ACSL1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004401
Super-classes obo:TXPO_0004399c
obo:TXPO_0005063c

HNF4A inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004402
Super-classes obo:TXPO_0002340c
obo:TXPO_0004620c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004622c
obo:TXPO_0000069op some obo:TXPO_0004577c
obo:TXPO_0000069op some obo:TXPO_0004422c

positive regulation of cell division [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004403
Super-classes obo:GO_0051781c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004633c
obo:RO_0000057op some obo:TXPO_0004498c
obo:TXPO_0000774op only obo:TXPO_0004280c

tumor cell invasion [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004404
Super-classes obo:TXPO_0001231c
obo:TXPO_0002340c
Restrictions obo:RO_0002233op some (obo:CL_0000000c and ub744bL103885C17c)
obo:TXPO_0000774op only obo:TXPO_0004280c

Increasing ACSL4 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004405
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004406c
Sub-classes obo:TXPO_0004407c

ACSL4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004406
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004408c

Increasing ACSL4 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004407
Super-classes obo:TXPO_0002340c
obo:TXPO_0004405c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004410c
obo:RO_0002234op some obo:TXPO_0004408c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004409c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000069op some obo:TXPO_0004403c
obo:TXPO_0000069op some obo:TXPO_0004402c

ACSL4 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004408
Super-classes obo:TXPO_0004406c
obo:TXPO_0005063c

Increasing COX-2 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004409
Super-classes obo:TXPO_0004471c
obo:TXPO_0002340c
Restrictions obo:RO_0002234op some obo:TXPO_0004472c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004410c
obo:TXPO_0000069op some obo:TXPO_0004404c

positive regulation of arachidonic acid metabolic process [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004410
Super-classes obo:TXPO_0002340c
obo:TXPO_0004920c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002213op some obo:TXPO_0003884c

Increasing AGGF1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004411
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000502c
Sub-classes obo:TXPO_0004412c

Increasing AGGF1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004412
Super-classes obo:TXPO_0002340c
obo:TXPO_0004411c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004413c
obo:TXPO_0001868op some obo:TXPO_0004415c
obo:RO_0002234op some obo:TXPO_0004195c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004414c

Increasing VEGF level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004413
Super-classes obo:TXPO_0002340c
obo:TXPO_0004856c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004858c
obo:RO_0002234op some obo:TXPO_0004857c
obo:TXPO_0000069op some obo:TXPO_0004603c

AGGF1 signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004414
Super-classes obo:TXPO_0005065c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004417c
obo:BFO_0000051op some obo:TXPO_0004412c
obo:RO_0000057op some obo:TXPO_0004195c
obo:TXPO_0000774op only obo:TXPO_0004280c

OR3A4 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004415
Description

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is transcribed and contains an intact ORF, but it is predicted to be a pseudogene due to a poorly conserved 7-transmembrane domain structure.
Super-classes obo:OGG_3000390756c
obo:TXPO_0004185c

negative regulation of AKT signaling [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004416
Super-classes obo:TXPO_0001987c
obo:GO_0051898c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004379c

AKT signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004417
Description

PMID:30690589
Super-classes obo:TXPO_0001494c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004418c
obo:TXPO_0000069op some obo:TXPO_0004420c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004419c
obo:TXPO_0000069op some obo:TXPO_0004421c
obo:TXPO_0000069op some obo:TXPO_0004403c
obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000069op some obo:TXPO_0004391c
obo:TXPO_0000069op some obo:TXPO_0004396c

GSK3beta signal (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004418
Super-classes obo:TXPO_0004576c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004577c
obo:TXPO_0000774op only obo:TXPO_0004280c

TOR signaling (primitive)　[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004419
Super-classes obo:TXPO_0002340c
obo:TXPO_0004028c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004464c
obo:TXPO_0000069op some obo:TXPO_0004457c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004837c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000069op some obo:TXPO_0004745c
obo:TXPO_0002524op some obo:GO_0031929c
obo:TXPO_0000069op some obo:TXPO_0004603c
obo:RO_0000057op some obo:TXPO_0004836c

p38 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004420
Super-classes obo:TXPO_0002340c
obo:TXPO_0004303c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004298c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004403c

Metalloprotease activation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004421
Super-classes obo:TXPO_0005001c
obo:TXPO_0002340c
Restrictions obo:BFO_0000051op some obo:TXPO_0004695c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:RO_0002233op some obo:TXPO_0005002c
obo:RO_0002233op some obo:TXPO_0005003c

epithelial to mesenchymal transition [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004422
Super-classes obo:TXPO_0002340c
obo:GO_0001837c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004404c
obo:RO_0000057op some obo:TXPO_0004872c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004899c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:TXPO_0000069op some obo:TXPO_0005014c

APC signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004423
Super-classes obo:TXPO_0000609c

APC signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004424
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004423c

negative regulation of APC signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004425
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:TXPO_0004424c
obo:RO_0002212op some obo:TXPO_0004423c
Sub-classes obo:TXPO_0004426c

negative regulation of APC signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004426
Super-classes obo:TXPO_0004425c
obo:TXPO_0002340c
Restrictions obo:RO_0002212op some obo:TXPO_0004424c
obo:TXPO_0000069op some obo:TXPO_0004427c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002212op some obo:TXPO_0004423c

negative regulation of EPCR signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004427
Super-classes obo:TXPO_0004532c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004417c
obo:RO_0002212op some obo:TXPO_0004531c
obo:RO_0002212op some obo:TXPO_0004530c
obo:RO_0000057op some obo:TXPO_0004533c
obo:TXPO_0000774op only obo:TXPO_0004280c

ATF4 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004428
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000012c and ub744bL104391C17c)
Sub-classes obo:TXPO_0004429c

ATF4 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004429
Super-classes obo:TXPO_0004428c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004431c
obo:RO_0002234op some obo:TXPO_0004430c
obo:TXPO_0000774op only obo:TXPO_0004280c

ATF4 - inactive form (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004430
Super-classes obo:TXPO_0005067c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0000819op some obo:OGG_3000000468c
obo:TXPO_0002260op some obo:IMR_0000825c
obo:RO_0000086op some obo:PATO_0002355c

PMAIP1 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004431
Super-classes obo:TXPO_0002340c
obo:TXPO_0004762c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004764c
obo:TXPO_0000069op some obo:TXPO_0004403c
obo:RO_0002234op some obo:TXPO_0004763c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004396c

ATF6 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004432
Super-classes obo:TXPO_0000718c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004433c
obo:TXPO_0000069op some obo:TXPO_0004434c
obo:TXPO_0000774op only obo:TXPO_0004280c

ATF6(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004433
Super-classes obo:TXPO_1000013c
obo:TXPO_0005063c
Restrictions obo:TXPO_0002260op some obo:IMR_0000825c

Grp78 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004434
Super-classes obo:TXPO_0004539c
obo:TXPO_0002340c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004540c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004578c
obo:TXPO_0000069op some obo:TXPO_0004579c

Negative regulation of ATP transpotc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004435
Super-classes obo:TXPO_0002682c
Sub-classes obo:TXPO_0004436c

Negative regulation of ATP transport [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004436
Super-classes obo:TXPO_0001987c
obo:TXPO_0004435c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

Increasing BCL-2 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004437
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004438c

Increasing BCL-2 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004438
Super-classes obo:TXPO_0002340c
obo:TXPO_0004437c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004417c
obo:TXPO_0000774op only obo:TXPO_0004280c

C9ORF72 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004439
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000054c and ub744bL104574C17c)
Sub-classes obo:TXPO_0004440c

C9ORF72 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004440
Super-classes obo:TXPO_0001987c
obo:TXPO_0004439c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004445c
obo:TXPO_0000069op some obo:TXPO_0004443c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004442c
obo:TXPO_0000069op some obo:TXPO_0004444c
obo:RO_0002234op some obo:TXPO_0004441c

C9orf72_inactivated (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004441
Super-classes obo:TXPO_0004171c
Restrictions obo:TXPO_0000819op some obo:OGG_3000203228c
obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000086op some obo:TXPO_0000657c

positive regulation of autophagy [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004442
Super-classes obo:GO_0010508c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004928c

positive regulation of mitophagy [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004443
Super-classes obo:TXPO_0001987c
obo:GO_1901526c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002010c
obo:RO_0002213op some obo:GO_0000423c
obo:TXPO_0000774op only obo:TXPO_0001986c

Dysregulation of mitochondrion organizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004444
Super-classes obo:TXPO_0001987c
obo:TXPO_0004997c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004350c
obo:TXPO_0000774op only obo:TXPO_0001986c

Increasing mitochondrial membrane potential [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004445
Super-classes obo:TXPO_0001987c
obo:TXPO_0005000c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:BFO_0000066op only obo:GO_0031966c

CAR activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004446
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_0003862c and ub744bL104715C17c)
Sub-classes obo:TXPO_0004447c

CAR activation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004447
Super-classes obo:TXPO_0002340c
obo:TXPO_0004446c
Restrictions obo:RO_0000057op some obo:TXPO_0004449c
obo:RO_0000057op some obo:TXPO_0004448c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0002234op some obo:TXPO_0004450c

phenobarbital [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004448
Super-classes ()
obo:CHEBI_8069c
obo:TXPO_0004455c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9989c

1,4-bis[2-(3,5-dichloropyridyloxy)]benzene [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004449
Super-classes ()
obo:TXPO_0004819c
obo:TXPO_0004455c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9989c

CAR - activation state (mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004450
Super-classes obo:TXPO_0005071c
Restrictions obo:RO_0000086op some obo:PATO_0002354c

CCL2 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004451
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0038151c
obo:RO_0000057op some obo:TXPO_1000086c
Sub-classes obo:TXPO_0004452c

CCL2 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004452
Super-classes obo:TXPO_0004451c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004276c
obo:RO_0000057op some obo:TXPO_0004291c
obo:TXPO_0002524op some obo:GO_0038151c
obo:BFO_0000051op some obo:TXPO_0004289c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004453c

hepatic cirrhosis [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004453
Super-classes obo:TXPO_0002202c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004542c
obo:RO_0000057op some obo:TXPO_0004454c

CCL4 [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004454
Super-classes obo:CHEBI_27385c
obo:TXPO_0004455c
Restrictions obo:RO_0000087op some obo:TXPO_0003572c
obo:RO_0000087op some obo:TXPO_0004314c
obo:RO_0000087op some obo:TXPO_0002250c

hepatocarcinogenesis dependent chemical compoundc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004455
Super-classes obo:TXPO_0000199c
Sub-classes obo:TXPO_0004907c
obo:TXPO_0004705c
obo:TXPO_0004922c
obo:TXPO_0004676c
obo:TXPO_0005138c
obo:TXPO_0005008c
obo:TXPO_0004891c
obo:TXPO_0005060c
obo:TXPO_0004909c
obo:TXPO_0004971c
obo:TXPO_0004498c
obo:TXPO_0004537c
obo:TXPO_0004567c
obo:TXPO_0004674c
obo:TXPO_0004948c
obo:TXPO_0004513c
obo:TXPO_0004934c
obo:TXPO_0005062c
obo:TXPO_0004892c
obo:TXPO_0004449c
obo:TXPO_0004503c
obo:TXPO_0004704c
obo:TXPO_0004675c
obo:TXPO_0004969c
obo:TXPO_0004448c
obo:TXPO_0004504c
obo:TXPO_0004516c
obo:TXPO_0004454c
obo:TXPO_0004961c
obo:TXPO_0004502c
obo:TXPO_0004924c

Increasing CCND1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004456
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000088c
Sub-classes obo:TXPO_0004457c

Increasing CCND1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004457
Super-classes obo:TXPO_0002340c
obo:TXPO_0004456c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004459c
obo:RO_0002234op some obo:TXPO_0004458c

CCND1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004458
Super-classes obo:TXPO_1000088c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000595c

positive regulation of cell cycle [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004459
Super-classes obo:GO_0045787c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002213op some obo:GO_0007049c
obo:TXPO_0000069op some obo:TXPO_0004403c

CDK1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004460
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000521c and ub744bL104965C17c)
Sub-classes obo:TXPO_0004461c

CDK1 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004461
Super-classes obo:TXPO_0001987c
obo:TXPO_0004460c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004375c
obo:RO_0002234op some obo:TXPO_0004462c
obo:TXPO_0000774op only obo:TXPO_0001986c

CDK1 - inactive form (predicted) (human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004462
Super-classes obo:TXPO_0003603c
obo:TXPO_0003611c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000983c
obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000086op some obo:TXPO_0000657c

Increasing CDK2 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004463
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:IMR_0100598c
Sub-classes obo:TXPO_0004464c

Increasing CDK2 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004464
Super-classes obo:TXPO_0002340c
obo:TXPO_0004463c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004459c
obo:RO_0002234op some obo:TXPO_0004465c

CDK2 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004465
Super-classes obo:IMR_0100598c
obo:TXPO_0004185c

CDT1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004466
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004467c and ub744bL105060C17c)
Sub-classes obo:TXPO_0004468c

CDT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004467
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005075c

CDT1 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004468
Super-classes obo:TXPO_0004466c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004470c
obo:RO_0002234op some obo:TXPO_0004469c

CDT1 - inactive form (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004469
Super-classes obo:TXPO_0005075c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

Removing damaged DNA stress [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004470
Super-classes obo:TXPO_0004499c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004431c

Increasing COX-2 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004471
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:IMR_0000735c
Sub-classes obo:TXPO_0004409c

COX-2 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004472
Super-classes obo:TXPO_0005063c
obo:IMR_0000735c

increasing CPT1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004473
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004369c

CPT1(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004474
Super-classes obo:TXPO_0004293c
obo:TXPO_1000097c

Decreasing CXCL8 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004475
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:TXPO_1000510c
Sub-classes obo:TXPO_0004476c

Decreasing CXCL8 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004476
Super-classes obo:TXPO_0004475c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004477c
obo:RO_0002233op some obo:TXPO_0004198c

negative regulation of cellular senescence [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004477
Super-classes obo:GO_2000773c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c

chemokine (C-X-C motif) ligand 8 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004478
Super-classes obo:GO_0032602c
Restrictions obo:RO_0002234op some obo:TXPO_1000510c
Sub-classes obo:TXPO_0004394c

metastasis [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004479
Super-classes obo:TXPO_0002340c
obo:NCIT_C19151c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c

CXCR3 signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004480
Super-classes obo:TXPO_0004481c
obo:TXPO_0002340c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004484c
obo:TXPO_0000069op some obo:TXPO_0004483c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004482c

CXCR3 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004481
Super-classes obo:GO_0023052c
Restrictions obo:RO_0000057op some obo:TXPO_1000077c
obo:TXPO_0002524op some obo:TXPO_0004484c
Sub-classes obo:TXPO_0004480c

CXCR3(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004482
Super-classes obo:TXPO_0005063c
obo:TXPO_1000077c

endothelial progenitor cell mobilization [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004483
Super-classes obo:TXPO_0005045c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004603c

CXCR3 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004484
Super-classes obo:TXPO_0000609c

Increasing CXCR4 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004485
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004486c
Sub-classes obo:TXPO_0004487c

CXCR4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004486
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004488c

Increasing CXCR4 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004487
Super-classes obo:TXPO_0002340c
obo:TXPO_0004485c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004488c
obo:TXPO_0000069op some obo:TXPO_0004417c
obo:TXPO_0000069op some obo:TXPO_0004489c

CXCR4 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004488
Super-classes obo:TXPO_0004486c
obo:TXPO_0004185c

JNK signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004489
Super-classes obo:TXPO_0000769c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004391c
obo:TXPO_0000069op some obo:TXPO_0004394c
obo:TXPO_0000774op only obo:TXPO_0004280c

Decreasing CYP1A2 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004490
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:TXPO_1000512c
Sub-classes obo:TXPO_0004491c

Decreasing CYP1A2 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004491
Super-classes obo:TXPO_0004490c
obo:TXPO_0002340c
Restrictions obo:RO_0002233op some obo:TXPO_0004202c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004492c

Hypofunction of 17β-Estradiol metabolic process [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004492
Super-classes obo:TXPO_0002340c
obo:TXPO_0005061c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op some obo:CHEBI_16469c
obo:RO_0000057op some obo:TXPO_0004202c
obo:TXPO_0000069op some obo:TXPO_0004518c

Hyperfunction of CYP2E1 gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004493
Super-classes obo:TXPO_0002051c
Sub-classes obo:TXPO_0004366c

Connexin signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004494
Super-classes obo:TXPO_0000609c

connexin signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004495
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004494c
Sub-classes obo:TXPO_0004949c

negative regulation of connexin signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004496
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:TXPO_0004494c
obo:RO_0002212op some obo:TXPO_0004495c
Sub-classes obo:TXPO_0004952c

DNA alkylation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004497
Super-classes obo:GO_0006305c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004498c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c

chloroethene [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004498
Super-classes obo:CHEBI_28509c
obo:TXPO_0004455c

Removing damaged DNA stressc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004499
Super-classes obo:TXPO_0000619c
Sub-classes obo:TXPO_0004470c

formation of DNA adductsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004500
Super-classes obo:GO_0005488c
Sub-classes obo:TXPO_0004501c

formation of DNA adducts [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004501
Description

In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could be the start of a cancerous cell, or carcinogenesis.
Super-classes obo:TXPO_0004500c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004503c
obo:RO_0000057op some obo:TXPO_0004504c
obo:TXPO_0000069op some obo:TXPO_0004507c
obo:TXPO_0000069op some obo:TXPO_0004505c
obo:RO_0000057op some obo:TXPO_0004502c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004506c
obo:RO_0000057op some obo:TXPO_0004498c

malondialdehyde [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004502
Super-classes obo:CHEBI_566274c
obo:TXPO_0004455c

riddelliine [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004503
Description

A macrolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
Super-classes obo:CHEBI_63924c
obo:TXPO_0004455c

cyproterone acetate [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004504
Super-classes obo:CHEBI_50743c
obo:TXPO_0004455c
Restrictions obo:RO_0000087op some obo:CHEBI_35497c

DNA damage [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004505
Super-classes obo:NCIT_C16507c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0000057op some obo:TXPO_0004513c
obo:TXPO_0000774op only obo:TXPO_0004280c

proto-oncogene mutation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004506
Super-classes obo:TXPO_0004890c
obo:TXPO_0002340c
Restrictions obo:RO_0002233op some obo:TXPO_0004873c
obo:RO_0000057op some obo:TXPO_0004891c
obo:RO_0002233op some obo:TXPO_0004896c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0000057op some obo:TXPO_0004704c
obo:RO_0000057op some obo:TXPO_0004892c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op some obo:TXPO_0004894c
obo:RO_0002233op some obo:TXPO_0004893c
obo:RO_0000057op some obo:TXPO_0004498c
obo:RO_0000057op some obo:TXPO_0004705c
obo:RO_0002233op some obo:TXPO_0004895c

tumor suppressor gene mutation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004507
Super-classes obo:TXPO_0004902c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004498c
obo:RO_0000057op some obo:TXPO_0004907c
obo:RO_0002233op some obo:TXPO_0005049c
obo:TXPO_0000069op some obo:TXPO_0004392c

negative regulation of DNA repair [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004508
Super-classes obo:TXPO_0002340c
obo:GO_0045738c
Restrictions obo:RO_0000057op some obo:TXPO_0004511c
obo:RO_0002212op some obo:GO_0006281c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004512c
obo:RO_0000057op some obo:TXPO_0004509c
obo:RO_0000057op some obo:TXPO_0004510c

HOTAIR (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004509
Super-classes obo:TXPO_0005092c
obo:TXPO_0005063c

MSH2 - inactive form (canonical)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004510
Super-classes obo:TXPO_0005063c
obo:TXPO_0005099c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

MSH6 - inactive form (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004511
Super-classes obo:TXPO_0005101c
obo:TXPO_0005063c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

induction of genomic instability [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004512
Super-classes obo:TXPO_0004947c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c

2-acetamidofluorene [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004513
Super-classes obo:TXPO_0004455c
obo:CHEBI_17356c

Hyperfunction of DNA biosynthesis [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004514
Super-classes obo:TXPO_0002340c
obo:TXPO_0004515c
Restrictions obo:TXPO_0001502op some obo:GO_0071897c
obo:RO_0000057op some obo:TXPO_0004516c
obo:TXPO_0000774op only obo:TXPO_0004280c

Hyperfunction of DNA biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004515
Super-classes obo:TXPO_0002346c
Restrictions obo:TXPO_0001502op some obo:GO_0071897c
Sub-classes obo:TXPO_0004514c

fumonisin B1 [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004516
Super-classes obo:CHEBI_38221c
obo:TXPO_0004455c

DNA replication [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004517
Super-classes obo:GO_0006260c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0001868op some obo:TXPO_0004519c
obo:TXPO_0000531op some obo:TXPO_0000304c

Tumor cell proliferation [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004518
Super-classes obo:TXPO_0000339c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004930c

FEN1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004519
Super-classes obo:TXPO_1000515c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002237c

Increasing DNMT1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004520
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004521c
Sub-classes obo:TXPO_0004522c

DNMT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004521
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004523c
obo:TXPO_0004851c

Increasing DNMT1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004522
Super-classes obo:TXPO_0002340c
obo:TXPO_0004520c
Restrictions obo:RO_0000057op some obo:TXPO_0004448c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004523c

DNMT1 (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004523
Super-classes obo:TXPO_0004521c
obo:TXPO_0005070c

Increasing DPYD levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004524
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000514c
Sub-classes obo:TXPO_0004525c

Increasing DPYD level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004525
Super-classes obo:TXPO_0002340c
obo:TXPO_0004524c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004420c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:RO_0002234op some obo:TXPO_0004192c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000774op only obo:TXPO_0004280c

EGFR signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004526
Super-classes obo:TXPO_0002340c
obo:TXPO_0001492c
Restrictions obo:RO_0000057op some obo:TXPO_0004528c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004527c
obo:TXPO_0002524op some obo:GO_0007173c
obo:TXPO_0000069op some obo:TXPO_0004529c

EGFR(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004527
Super-classes obo:IMR_0000081c
obo:TXPO_0005063c
Restrictions obo:TXPO_0002260op some obo:IMR_0000081c

EGFR(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004528
Super-classes obo:TXPO_0004185c
obo:IMR_0000081c
Restrictions obo:TXPO_0002260op some obo:IMR_0000081c

sorafenib resistance (process) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004529
Super-classes obo:TXPO_0004965c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000774op only obo:TXPO_0004280c

EPCR signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004530
Super-classes obo:TXPO_0000609c

EPCR signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004531
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004530c

negative regulation of EPCR signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004532
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:TXPO_0004530c
obo:RO_0002212op some obo:TXPO_0004531c
Sub-classes obo:TXPO_0004427c

PROCR (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004533
Super-classes obo:TXPO_0005128c
obo:TXPO_0005070c

ERK signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004534
Super-classes obo:TXPO_0000609c

ERK signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004535
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004534c
Sub-classes obo:TXPO_0004536c

ERK signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004536
Super-classes obo:TXPO_0002340c
obo:TXPO_0004535c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004538c
obo:TXPO_0002524op some obo:TXPO_0004534c
obo:RO_0000057op some obo:TXPO_0004537c
obo:TXPO_0000774op only obo:TXPO_0004280c

pentadecafluorooctanoic acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004537
Super-classes obo:CHEBI_35549c
obo:TXPO_0004455c

negative regulation of gap-junctional intercellular communication [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004538
Super-classes obo:TXPO_0004572c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c

Grp78 signal (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004539
Super-classes obo:GO_0023052c
Restrictions obo:RO_0000057op some obo:TXPO_0001002c
obo:TXPO_0002524op some obo:TXPO_0004540c
Sub-classes obo:TXPO_0004434c

Grp78 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004540
Super-classes obo:TXPO_0000609c

increasing demand for response to ER stress [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004541
Super-classes obo:TXPO_0000362c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000069op some obo:TXPO_0004403c
obo:TXPO_0000069op some obo:TXPO_0004543c
obo:TXPO_0000069op some obo:TXPO_0004542c

inflammatory response [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004542
Super-classes obo:TXPO_0002340c
obo:TXPO_0000192c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:BFO_0000066op some obo:UBERON_0002107c

increasing demand for response to oxidative stress [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004543
Super-classes obo:TXPO_0002340c
obo:TXPO_0000102c
Restrictions obo:RO_0000057op some obo:TXPO_0004516c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004505c
obo:TXPO_0000069op some obo:TXPO_0005035c

FAK signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004544
Super-classes obo:TXPO_0000609c

FAK signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004545
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004544c
Sub-classes obo:TXPO_0004546c

FAK signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004546
Super-classes obo:TXPO_0004545c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004547c
obo:TXPO_0000069op some obo:TXPO_0004417c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0002524op some obo:TXPO_0004544c

PTK2 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004547
Super-classes obo:TXPO_0005063c
obo:TXPO_0005130c

FAS signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004548
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0036337c
Sub-classes obo:TXPO_0004549c

FAS signaling [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004549
Super-classes obo:TXPO_0004548c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004017c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:TXPO_0002524op some obo:GO_0036337c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004271c

increasing FGF21 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004550
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004551c

increasing FGF21 level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004551
Super-classes obo:TXPO_0004550c
obo:TXPO_0001987c
Restrictions obo:RO_0002234op some obo:TXPO_0004552c
obo:TXPO_0000774op only obo:TXPO_0001986c

FGF21(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004552
Super-classes obo:TXPO_0004293c
obo:TXPO_1000145c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026291c
obo:TXPO_0002260op some obo:IMR_0100571c

FGF2 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004553
Super-classes obo:TXPO_0000609c

FGF2 signal (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004554
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004553c
obo:RO_0000057op some obo:TXPO_1000144c
Sub-classes obo:TXPO_0004555c

FGF2 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004555
Super-classes obo:TXPO_0004554c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004557c
obo:TXPO_0002524op some obo:TXPO_0004553c
obo:RO_0000057op some obo:TXPO_0004556c
obo:TXPO_0000774op only obo:TXPO_0004280c

FGF2 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004556
Super-classes obo:TXPO_0005063c
obo:TXPO_1000144c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002247c

WNT signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004557
Super-classes obo:TXPO_0002340c
obo:TXPO_0004860c
Restrictions obo:RO_0000057op some obo:TXPO_0004863c
obo:RO_0000057op some obo:IMR_0000003c
obo:TXPO_0000069op some obo:TXPO_0004577c
obo:RO_0000057op some obo:TXPO_0004866c
obo:RO_0000057op some obo:TXPO_0004865c
obo:RO_0000057op some obo:TXPO_0004862c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0002524op some obo:TXPO_0004859c
obo:RO_0000057op some obo:TXPO_0004861c
obo:RO_0000057op some obo:TXPO_0004864c

FOXO1 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004558
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_0003221c and ub744bL106412C17c)
Sub-classes obo:TXPO_0004559c

FOXO1 activation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004559
Super-classes obo:TXPO_0001987c
obo:TXPO_0004558c
Restrictions obo:RO_0002234op some obo:TXPO_0004560c
obo:TXPO_0000069op some obo:TXPO_0004561c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004390c

FOXO1 - activation state (canonical)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004560
Super-classes obo:TXPO_0005080c
Restrictions obo:RO_0000086op some obo:PATO_0002354c
obo:TXPO_0002260op some obo:IMR_0002805c
obo:RO_0000087op some obo:TXPO_0003947c

Hypofunction of heme biosynthesis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004561
Super-classes obo:TXPO_0005053c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000716op some obo:GO_0006783c
obo:TXPO_0000069op some obo:TXPO_0004225c

FZDc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004562
Super-classes obo:TXPO_0004563c
Sub-classes obo:TXPO_0005083c
obo:TXPO_0005081c
obo:TXPO_0005082c
obo:TXPO_0005084c
obo:TXPO_0005086c
obo:TXPO_0005085c

GPCRc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004563
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004562c

Decreasing GADD45G levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004564
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:TXPO_0004565c
Sub-classes obo:TXPO_0004566c

GADD45G (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004565
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004568c

Decreasing GADD45G level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004566
Super-classes obo:TXPO_0004564c
obo:TXPO_0002340c
Restrictions obo:RO_0002233op some obo:TXPO_0004568c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004567c
obo:RO_0000057op some obo:TXPO_0004448c

clofibrate [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004567
Description

Clofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia. Clofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury.
Super-classes obo:TXPO_0004455c
()
obo:CHEBI_3750c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9989c

GADD45G (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004568
Super-classes obo:TXPO_0005070c
obo:TXPO_0004565c

Increasing GDF15 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004569
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000164c
Sub-classes obo:TXPO_0000075c
obo:TXPO_0004570c

Increasing GDF15 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004570
Super-classes obo:TXPO_0002340c
obo:TXPO_0004569c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:RO_0000057op some obo:TXPO_0004448c
obo:RO_0002234op some obo:TXPO_0004571c

GDF15(rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004571
Super-classes obo:TXPO_1000164c
obo:TXPO_0005070c

negative regulation of gap-junctional intercellular communicationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004572
Super-classes obo:TXPO_0000369c
Sub-classes obo:TXPO_0004538c

Decreasing GPHN levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004573
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:TXPO_1000517c
Sub-classes obo:TXPO_0004574c

Decreasing GPHN level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004574
Super-classes obo:TXPO_0004573c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004419c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op some obo:TXPO_0004188c

GSK3beta signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004575
Super-classes obo:TXPO_0000609c

GSK3beta signal (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004576
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004575c
Sub-classes obo:TXPO_0004418c

beta-catenin signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004577
Super-classes obo:TXPO_0004871c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000069op some obo:TXPO_0004538c
obo:TXPO_0000069op some obo:TXPO_0004453c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004872c
obo:RO_0000057op some obo:TXPO_0004873c
obo:TXPO_0000069op some obo:TXPO_0004874c
obo:TXPO_0000069op some obo:TXPO_0004818c
obo:TXPO_0000069op some obo:TXPO_0004695c

GRP78 (canonical)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004578
Super-classes obo:TXPO_0000871c
obo:TXPO_0001002c
Restrictions obo:RO_0000087op some obo:TXPO_0003997c

cisplatin resistance [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004579
Super-classes obo:TXPO_0004957c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004518c

Increasing HBEGF levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004580
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004581c
Sub-classes obo:TXPO_0004582c

HBEGF (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004581
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004583c

Increasing HBEGF level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004582
Super-classes obo:TXPO_0002340c
obo:TXPO_0004580c
Restrictions obo:RO_0000057op some obo:TXPO_0004448c
obo:RO_0002234op some obo:TXPO_0004583c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0000774op only obo:TXPO_0004280c

HBEGF (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004583
Super-classes obo:TXPO_0005070c
obo:TXPO_0004581c

HBV infectionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004584
Super-classes obo:TXPO_0002139c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
Sub-classes obo:TXPO_0004585c

HBV infection [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004585
Super-classes obo:TXPO_0004584c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004589c
obo:TXPO_0000069op some obo:TXPO_0004508c
obo:TXPO_0000069op some obo:TXPO_0004588c
obo:TXPO_0000069op some obo:TXPO_0004507c
obo:TXPO_0000069op some obo:TXPO_0004593c
obo:TXPO_0000069op some obo:TXPO_0004417c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004557c
obo:TXPO_0000069op some obo:TXPO_0004541c
obo:TXPO_0000069op some obo:TXPO_0004592c
obo:TXPO_0000069op some obo:TXPO_0004453c
obo:TXPO_0000069op some obo:TXPO_0004590c
obo:TXPO_0000069op some obo:TXPO_0004587c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000069op some obo:TXPO_0004591c
obo:TXPO_0000069op some obo:TXPO_0004586c

Notch signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004586
Super-classes obo:TXPO_0004724c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004459c
obo:RO_0000057op some obo:TXPO_0004725c
obo:RO_0000057op some obo:TXPO_0004727c
obo:TXPO_0000069op some obo:TXPO_0004298c
obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0002524op some obo:GO_0007219c
obo:TXPO_0000069op some obo:TXPO_0004728c
obo:RO_0000057op some obo:TXPO_0004726c

STAT3 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004587
Super-classes obo:TXPO_0002340c
obo:TXPO_0004807c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:BFO_0000051op some obo:TXPO_0004787c
obo:TXPO_0000069op some obo:TXPO_0004395c
obo:RO_0000057op some obo:TXPO_0004808c
obo:TXPO_0000069op some obo:TXPO_0004809c
obo:TXPO_0000069op some obo:TXPO_0004518c

TGF beta receptor signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004588
Super-classes obo:TXPO_0002340c
obo:TXPO_0001854c
Restrictions obo:RO_0000057op some obo:TXPO_0004516c
obo:RO_0000057op some obo:TXPO_0004827c
obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000069op some obo:TXPO_0004828c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c

c-Src signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004589
Super-classes obo:TXPO_0004875c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0002524op some obo:TXPO_0004805c
obo:RO_0000057op some obo:TXPO_0004876c
obo:TXPO_0000069op some obo:TXPO_0004422c

telomerase reverse transcriptase gene mutation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004590
Super-classes obo:TXPO_0002340c
obo:TXPO_0004966c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op some obo:TXPO_0004967c

necrosis [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004591
Super-classes obo:TXPO_0002340c
obo:GO_0070265c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0000057op some obo:TXPO_0004969c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004507c

dysregulation of immune balance [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004592
Super-classes obo:TXPO_0005018c
obo:TXPO_0002340c
Restrictions obo:BFO_0000051op some obo:TXPO_0004828c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:BFO_0000051op some obo:TXPO_0005019c
obo:TXPO_0000774op only obo:TXPO_0004280c

hepatocyte regeneration [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004593
Super-classes obo:TXPO_0005037c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000069op some obo:TXPO_0004507c
obo:RO_0000057op some obo:TXPO_0004969c

HCV infectionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004594
Super-classes obo:TXPO_0002139c
Restrictions obo:BFO_0000066op some obo:UBERON_0002107c
Sub-classes obo:TXPO_0004595c

HCV infection [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004595
Super-classes obo:TXPO_0002340c
obo:TXPO_0004594c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004453c
obo:TXPO_0000069op some obo:TXPO_0004557c
obo:TXPO_0000069op some obo:TXPO_0004597c
obo:TXPO_0000069op some obo:TXPO_0004555c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004596c

Increasing MIR135A level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004596
Super-classes obo:TXPO_0004690c
obo:TXPO_0002340c
Restrictions obo:RO_0002234op some obo:TXPO_0004692c
obo:TXPO_0000069op some obo:TXPO_0004693c
obo:RO_0002234op some obo:TXPO_0004691c
obo:TXPO_0000774op only obo:TXPO_0004280c

PPARalpha activation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004597
Super-classes obo:TXPO_0002340c
obo:TXPO_0000013c
Restrictions obo:RO_0002234op some obo:TXPO_0004770c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004759c
obo:RO_0000057op some obo:TXPO_0004567c

HGFR signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004598
Super-classes obo:TXPO_0002340c
obo:TXPO_0004599c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004603c
obo:TXPO_0002524op some obo:GO_0048012c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:RO_0000057op some obo:TXPO_0004602c
obo:BFO_0000051op some obo:TXPO_0004600c
obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004601c

HGFR signal (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004599
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0048012c
obo:RO_0000057op some obo:TXPO_0004604c
Sub-classes obo:TXPO_0004598c

Increasing HGF level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004600
Super-classes obo:TXPO_0004605c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004517c
obo:RO_0002234op some obo:TXPO_0004606c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004504c

HGF (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004601
Super-classes obo:TXPO_0004604c
obo:TXPO_0005063c

MET (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004602
Super-classes obo:TXPO_0005098c
obo:TXPO_0005063c

neovascularization [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004603
Super-classes obo:TXPO_0000134c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:RO_0000057op some obo:TXPO_0005047c

HGF (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004604
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004601c
obo:TXPO_0004606c

Increasing HGF levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004605
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004604c
Sub-classes obo:TXPO_0004600c

HGF (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004606
Super-classes obo:TXPO_0005070c
obo:TXPO_0004604c

HHIP inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004607
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004608c and ub744bL107342C17c)
Sub-classes obo:TXPO_0004609c

HHIP (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004608
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005089c

HHIP inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004609
Super-classes obo:TXPO_0002340c
obo:TXPO_0004607c
Restrictions obo:TXPO_0001868op some obo:TXPO_0004611c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004610c

HHIP - inactive form (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004610
Super-classes obo:TXPO_0005089c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

trimeric UHRF1 repression complex (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004611
Super-classes obo:TXPO_0004185c
obo:TXPO_0004850c
Restrictions obo:RO_0002180op some obo:TXPO_0004852c
obo:RO_0000087op some obo:TXPO_0000330c
obo:RO_0002180op some obo:TXPO_0004851c
obo:RO_0002180op some obo:TXPO_0004203c

HIF1A activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004612
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_0004613c and ub744bL107425C17c)
Sub-classes obo:TXPO_0004382c

HIF1A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004613
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005016c
obo:TXPO_0005090c

HIF1A - activation state (canonical)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004614
Super-classes obo:TXPO_0003603c
obo:TXPO_0005090c
Restrictions obo:RO_0000086op some obo:PATO_0002354c

Increasing HILPDA levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004615
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000518c
Sub-classes obo:TXPO_0004616c

Increasing HILPDA level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004616
Super-classes obo:TXPO_0002340c
obo:TXPO_0004615c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000069op some obo:TXPO_0004617c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:RO_0002234op some obo:TXPO_0004194c
obo:TXPO_0000774op only obo:TXPO_0004280c

Increasing iron uptake level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004617
Super-classes obo:TXPO_0002340c
obo:TXPO_0005052c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004661c
obo:TXPO_0000774op only obo:TXPO_0004280c

Increasing HMGB1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004618
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0000849c
Sub-classes obo:TXPO_0004377c

HMGB1 (canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004619
Super-classes obo:TXPO_0000849c
obo:TXPO_0003603c

HNF4A inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004620
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004621c and ub744bL107539C17c)
Sub-classes obo:TXPO_0004402c

HNF4A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004621
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005091c

HNF4A - inactive form (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004622
Super-classes obo:TXPO_0005091c
obo:TXPO_0005063c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

HULCc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004623
Super-classes obo:OGG_2100009606c
Sub-classes obo:TXPO_0004626c

Increasing HULC levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004624
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004623c
Sub-classes obo:TXPO_0004625c

Increasing HULC level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004625
Super-classes obo:TXPO_0004624c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004627c
obo:RO_0002234op some obo:TXPO_0004626c
obo:TXPO_0000774op only obo:TXPO_0004280c

HULC (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004626
Super-classes obo:TXPO_0004185c
obo:TXPO_0004623c

Increasing PPARA level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004627
Super-classes obo:TXPO_0002340c
obo:TXPO_0004765c
Restrictions obo:RO_0002234op some obo:TXPO_0004766c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004767c
obo:TXPO_0000069op some obo:TXPO_0004400c

Hedgehog signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004628
Super-classes obo:TXPO_0000609c

Hedgehog signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004629
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004628c
Sub-classes obo:TXPO_0004630c

Hedgehog signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004630
Super-classes obo:TXPO_0002340c
obo:TXPO_0004629c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004633c
obo:RO_0000057op some obo:TXPO_0004631c
obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0002524op some obo:TXPO_0004628c
obo:TXPO_0000069op some obo:TXPO_0004634c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004632c
obo:TXPO_0000069op some obo:TXPO_0004546c

IHH (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004631
Super-classes obo:IMR_0100739c
obo:TXPO_0005063c

SHH (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004632
Super-classes obo:IMR_0000005c
obo:TXPO_0005063c

neoplastic cell transformation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004633
Super-classes obo:TXPO_0002340c
obo:OMIT_0003800c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c

glycolytic process [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004634
Super-classes obo:GO_0006096c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000774op only obo:TXPO_0004280c

Hippo signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004635
Super-classes obo:TXPO_0000609c

Hippo signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004636
Super-classes obo:TXPO_0004637c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004640c
obo:TXPO_0002524op some obo:TXPO_0004635c
obo:RO_0000057op some obo:TXPO_0004639c
obo:RO_0000057op some obo:TXPO_0004638c

Hippo signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004637
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004635c
obo:RO_0000057op some obo:TXPO_0005093c
obo:RO_0000057op some obo:TXPO_0005094c
Sub-classes obo:TXPO_0004636c

MST1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004638
Super-classes obo:TXPO_0005093c
obo:TXPO_0005063c

STK3 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004639
Super-classes obo:TXPO_0005094c
obo:TXPO_0005063c

YAP signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004640
Super-classes obo:TXPO_0002340c
obo:TXPO_0004868c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004529c
obo:TXPO_0000069op some obo:TXPO_0004816c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004869c
obo:TXPO_0002524op some obo:TXPO_0004867c

UHRF1 productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004641
Super-classes obo:TXPO_0000382c
Restrictions obo:RO_0002234op some obo:TXPO_1000547c
Sub-classes obo:TXPO_0004728c

IFN alpha inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004642
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:IMR_0100386c and ub744bL107845C17c)
Sub-classes obo:TXPO_0004643c

IFN alpha inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004643
Super-classes obo:TXPO_0004642c
obo:TXPO_0002340c
Restrictions obo:RO_0002234op some (obo:IMR_0100386c and ub744bL107866C17c)
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004525c

IGFBP3 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004644
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004645c and ub744bL107893C17c)
Sub-classes obo:TXPO_0004646c

IGFBP3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004645
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005095c

IGFBP3 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004646
Super-classes obo:TXPO_0004644c
obo:TXPO_0002340c
Restrictions obo:TXPO_0001868op some obo:TXPO_0004611c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0002234op some obo:TXPO_0004647c
obo:TXPO_0000774op only obo:TXPO_0004280c

IGFBP3 - inactive form (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004647
Super-classes obo:TXPO_0004185c
obo:TXPO_0005095c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

IL-1B(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004648
Super-classes obo:TXPO_0004293c
obo:TXPO_1000200c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

IL-6 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004649
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:IMR_0000010c and ub744bL107964C17c)
Sub-classes obo:TXPO_0004650c

IL-6 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004650
Super-classes obo:TXPO_0004649c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004652c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004651c

IL-6 - inactive form (human)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004651
Super-classes obo:TXPO_0004185c
obo:TXPO_0004654c
Restrictions obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000087op some obo:TXPO_0003724c

KIAA0101 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004652
Super-classes obo:TXPO_0004677c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004678c
obo:TXPO_0000069op some obo:TXPO_0004650c
obo:TXPO_0000069op some obo:TXPO_0004679c

Increasing IL-6 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004653
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004654c
Sub-classes obo:TXPO_0004391c

IL-6(human)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004654
Super-classes obo:TXPO_0004185c
obo:IMR_0000010c
Restrictions obo:RO_0000087op some obo:TXPO_0003724c
Sub-classes obo:TXPO_0004651c

JAK signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004655
Super-classes obo:TXPO_0002340c
obo:TXPO_0004667c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004587c

IL1 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004656
Super-classes obo:TXPO_0002340c
obo:TXPO_0004657c
Restrictions obo:RO_0000057op some obo:TXPO_0004658c
obo:TXPO_0000069op some obo:TXPO_0004276c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:TXPO_0002524op some obo:GO_0070498c

IL1 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004657
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0070498c
Sub-classes obo:TXPO_0004656c

IL-1B(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004658
Super-classes obo:TXPO_1000200c
obo:TXPO_0005063c
Restrictions obo:RO_0000087op some obo:TXPO_0003041c

IL-6 signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004659
Super-classes obo:TXPO_0002340c
obo:TXPO_0004327c
Restrictions obo:TXPO_0002524op some obo:GO_0070102c
obo:RO_0000057op some obo:TXPO_0004660c
obo:TXPO_0000069op some obo:TXPO_0004276c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004661c

IL-6(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004660
Super-classes obo:IMR_0000010c
obo:TXPO_0005063c

Iron accumulation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004661
Super-classes obo:TXPO_0002340c
obo:TXPO_0003182c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op some obo:CHEBI_18248c
obo:TXPO_0000069op some obo:TXPO_0004543c

IP-10 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004662
Super-classes obo:TXPO_0000609c

IP-10 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004663
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004662c
obo:RO_0000057op some obo:TXPO_0003281c
Sub-classes obo:TXPO_0004664c

IP-10 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004664
Super-classes obo:TXPO_0002340c
obo:TXPO_0004663c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004662c
obo:TXPO_0000069op some obo:TXPO_0004432c
obo:TXPO_0000069op some obo:TXPO_0004480c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004665c

CXCL10 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004665
Super-classes obo:TXPO_0003281c
obo:TXPO_0005063c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:RO_0000056op some obo:TXPO_0000192c

JAK signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004666
Super-classes obo:TXPO_0000609c

JAK signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004667
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004666c
Sub-classes obo:TXPO_0004655c

Increasing JUN levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004668
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:IMR_0000416c
Sub-classes obo:TXPO_0004669c

Increasing JUN level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004669
Super-classes obo:TXPO_0004668c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0002234op some obo:TXPO_0004670c
obo:TXPO_0000774op only obo:TXPO_0004280c

JUN(mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004670
Super-classes obo:TXPO_0005072c
obo:IMR_0000416c

JUN gene promoter demethylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004671
Super-classes obo:TXPO_0004672c
Sub-classes obo:TXPO_0004673c

proto-oncogene promoter demethylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004672
Super-classes obo:GO_0070988c
Sub-classes obo:TXPO_0004671c
obo:TXPO_0004702c

JUN gene promoter demethylation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004673
Super-classes obo:TXPO_0004671c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004674c
obo:RO_0000057op some obo:TXPO_0004676c
obo:RO_0002233op some obo:TXPO_0004670c
obo:RO_0000057op some obo:TXPO_0004675c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004669c

dichloroacetic acid [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004674
Super-classes obo:TXPO_0004455c
obo:CHEBI_36386c

trichloroethylene [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004675
Super-classes obo:TXPO_0004455c
obo:CHEBI_16602c

trichloroacetic acid [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004676
Super-classes obo:CHEBI_30956c
obo:TXPO_0004455c

KIAA0101 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004677
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000520c and ub744bL108365C17c)
Sub-classes obo:TXPO_0004652c

KIAA0101 - inactive form (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004678
Super-classes obo:TXPO_0004193c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009768c
obo:RO_0000086op some obo:TXPO_0000657c

negative regulation of autophagy [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004679
Super-classes obo:GO_0010507c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004919c
obo:TXPO_0000774op only obo:TXPO_0004280c

Increasing KIAA0101 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004680
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000520c
Sub-classes obo:TXPO_0004681c

Increasing KIAA0101 tv1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004681
Super-classes obo:TXPO_0004680c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004479c
obo:TXPO_0000069op some obo:TXPO_0004633c
obo:RO_0002234op some obo:TXPO_0004682c
obo:TXPO_0000069op some obo:TXPO_0004683c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000774op only obo:TXPO_0004280c

KIAA0101 tv1 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004682
Super-classes obo:TXPO_0004185c
obo:TXPO_0004193c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009768c
obo:RO_0000086op some obo:TXPO_0000657c

negative regulation of signal transduction by p53 class mediator [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004683
Super-classes obo:GO_1901797c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004889c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:BFO_0000051op some obo:TXPO_0004800c

Decreasing LDLRAD4 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004684
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:TXPO_0004685c
Sub-classes obo:TXPO_0004686c

LDLRAD4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004685
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004687c

Decreasing LDLRAD4 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004686
Super-classes obo:TXPO_0004684c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004588c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op some obo:TXPO_0004687c

LDLRAD4 (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004687
Super-classes obo:TXPO_0005070c
obo:TXPO_0004685c

LDLRAD4 gene promoter methylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004688
Super-classes obo:GO_0006306c
Sub-classes obo:TXPO_0004689c

LDLRAD4 gene promoter methylation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004689
Super-classes obo:TXPO_0004688c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004686c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004454c
obo:RO_0002233op some obo:TXPO_0004687c

Increasing MIR135A levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004690
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004596c

MIR135A1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004691
Super-classes obo:OGG_3000406925c
obo:TXPO_0004185c

MIR135A2 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004692
Super-classes obo:OGG_3000406926c
obo:TXPO_0004185c

PTPRD inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004693
Super-classes obo:TXPO_0004785c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004787c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004786c

MMP7 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004694
Super-classes obo:TXPO_0000609c

MMP7 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004695
Super-classes obo:TXPO_0002340c
obo:TXPO_0004696c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004404c

MMP7 signal (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004696
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004694c
Sub-classes obo:TXPO_0004695c

Increasing MYC levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004697
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:IMR_0000383c
Sub-classes obo:TXPO_0004698c

Increasing MYC level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004698
Super-classes obo:TXPO_0004697c
obo:TXPO_0002340c
Restrictions obo:RO_0002234op some obo:TXPO_0004700c
obo:RO_0002234op some obo:TXPO_0004699c
obo:RO_0000057op some obo:TXPO_0004516c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0002234op some obo:TXPO_0004701c
obo:TXPO_0000774op only obo:TXPO_0004280c

Myc(mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004699
Super-classes obo:IMR_0000383c
obo:TXPO_0005072c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

Myc(rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004700
Super-classes obo:TXPO_0005070c
obo:IMR_0000383c
Restrictions obo:TXPO_0002260op some obo:IMR_0000383c

Myc (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004701
Super-classes obo:TXPO_0005063c
obo:IMR_0000383c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c

MYC gene promoter demethylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004702
Super-classes obo:TXPO_0004672c
Sub-classes obo:TXPO_0004703c

MYC gene promoter demethylation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004703
Super-classes obo:TXPO_0004702c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004675c
obo:RO_0000057op some obo:TXPO_0004674c
obo:TXPO_0000069op some obo:TXPO_0004698c
obo:RO_0000057op some obo:TXPO_0004448c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004676c
obo:RO_0002233op some obo:TXPO_0004700c
obo:RO_0002233op some obo:TXPO_0004699c

N-nitrosodiethylamine [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004704
Super-classes obo:CHEBI_34873c
obo:TXPO_0004455c

N-hydroxy-2-acetamidofluorene [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004705
Super-classes obo:CHEBI_17931c
obo:TXPO_0004455c

NDUFA12 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004706
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004707c and ub744bL108784C17c)
Sub-classes obo:TXPO_0005106c

NDUFA12 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004707
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005104c

NDUFB6 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004708
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004709c and ub744bL108809C17c)
Sub-classes obo:TXPO_0005109c

NDUFB6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004709
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005107c

NDUFS2 inactivaitonc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004710
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004711c and ub744bL108834C17c)
Sub-classes obo:TXPO_0005112c

NDUFS2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004711
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005110c

NDUFV1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004712
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004713c and ub744bL108859C17c)
Sub-classes obo:TXPO_0005115c

NDUFV1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004713
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005113c

NDUFV3 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004714
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004715c and ub744bL108884C17c)
Sub-classes obo:TXPO_0005118c

NDUFV3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004715
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005116c

Increasing production quantity of NOc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004716
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004717c

Increasing production quantity of NO [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004717
Super-classes obo:TXPO_0004716c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0000869c
obo:TXPO_0000069op some obo:TXPO_0004718c

increasing production quantity of RNS [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004718
Super-classes obo:TXPO_0000365c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004121c
obo:TXPO_0000069op some obo:TXPO_0000933c

NRF2 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004719
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0002527c and ub744bL108955C17c)
Sub-classes obo:TXPO_0004720c

NRF2 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004720
Super-classes obo:TXPO_0004719c
obo:TXPO_0001987c
Restrictions obo:RO_0002234op some obo:TXPO_0004721c
obo:TXPO_0000069op some obo:TXPO_0002005c
obo:TXPO_0000069op some obo:TXPO_0004723c
obo:TXPO_0000069op some obo:TXPO_0004722c
obo:TXPO_0000774op only obo:TXPO_0001986c

NRF2 - inactive form (canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004721
Super-classes obo:TXPO_0004293c
obo:TXPO_0005120c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

negative regulation of antioxidant enzyme activation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004722
Super-classes obo:TXPO_0005029c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004370c
obo:TXPO_0000774op only obo:TXPO_0001986c

hypofunction of lipid biosynthesis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004723
Super-classes obo:TXPO_0002195c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000716op some obo:GO_0008610c
obo:TXPO_0000774op only obo:TXPO_0001986c

Notch signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004724
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0007219c
Sub-classes obo:TXPO_0004586c

Notch 1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004725
Super-classes obo:IMR_0100714c
obo:TXPO_0005063c

Notch 2 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004726
Super-classes obo:TXPO_0005063c
obo:IMR_0100715c

Notch 3 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004727
Super-classes obo:IMR_0100716c
obo:TXPO_0005063c

UHRF1 production [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004728
Super-classes obo:TXPO_0002340c
obo:TXPO_0004641c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000069op some obo:TXPO_0004459c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:RO_0002234op some obo:TXPO_0004203c

ORC1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004729
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004730c and ub744bL109111C17c)
Sub-classes obo:TXPO_0004731c

ORC1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004730
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005121c

ORC1 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004731
Super-classes obo:TXPO_0002340c
obo:TXPO_0004729c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004470c
obo:RO_0002234op some obo:TXPO_0004732c
obo:TXPO_0000774op only obo:TXPO_0004280c

ORC1 - inactive form (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004732
Super-classes obo:TXPO_0005121c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

PANDAc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004733
Super-classes obo:OGG_2100009606c
Sub-classes obo:TXPO_0004736c

Increasing PANDA levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004734
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004733c
Sub-classes obo:TXPO_0004735c

Increasing PANDA level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004735
Super-classes obo:TXPO_0004734c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004476c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004736c

PANDA (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004736
Super-classes obo:TXPO_0004733c

PCK1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004737
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000521c and ub744bL109210C17c)
Sub-classes obo:TXPO_0004738c

PCK1 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004738
Super-classes obo:TXPO_0002340c
obo:TXPO_0004737c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002234op some obo:TXPO_0004739c

PCK1 - inactive form (human) [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004739
Super-classes obo:TXPO_0005122c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005105c
obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000086op some obo:TXPO_0000657c

PCK1 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004740
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_1000524c and ub744bL109267C17c)
Sub-classes obo:TXPO_0004741c

PCK1 activation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004741
Super-classes obo:TXPO_0001987c
obo:TXPO_0004740c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004126c
obo:TXPO_0000069op some obo:TXPO_0004742c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:RO_0002233op some obo:TXPO_0004176c
obo:TXPO_0000774op only obo:TXPO_0001986c

negative regulation of gluconeogenesis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004742
Super-classes obo:GO_0045721c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004264c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004941c

Increasing PCNA levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004743
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004744c
Sub-classes obo:TXPO_0004745c

PCNA (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004744
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004746c

Increasing PCNA level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004745
Super-classes obo:TXPO_0002340c
obo:TXPO_0004743c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004403c
obo:RO_0002234op some obo:TXPO_0004746c
obo:TXPO_0000774op only obo:TXPO_0004280c

PCNA (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004746
Super-classes obo:TXPO_0004744c
obo:TXPO_0004185c

PHB inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004747
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004748c and ub744bL109376C17c)
Sub-classes obo:TXPO_0004749c

PHB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004748
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005124c

PHB inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004749
Super-classes obo:TXPO_0004747c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004750c
obo:TXPO_0000069op some obo:TXPO_0004298c
obo:TXPO_0000069op some obo:TXPO_0004489c

PHB - inactive form (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004750
Super-classes obo:TXPO_0004185c
obo:TXPO_0005124c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

PI3K signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004751
Super-classes obo:TXPO_0000609c

PI3K signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004752
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004751c
Sub-classes obo:TXPO_0004753c

PI3K signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004753
Super-classes obo:TXPO_0004752c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004417c
obo:TXPO_0002524op some obo:TXPO_0004751c

PIM3 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004754
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:TXPO_1000525c and ub744bL109471C17c)
Sub-classes obo:TXPO_0004755c

PIM3 activation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004755
Super-classes obo:TXPO_0004754c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004758c
obo:RO_0002233op some obo:TXPO_0004756c
obo:TXPO_0000069op some obo:TXPO_0004459c
obo:TXPO_0000069op some obo:TXPO_0004603c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004759c
obo:TXPO_0000069op some obo:TXPO_0004757c

PIM3 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004756
Super-classes obo:TXPO_1000525c
Restrictions obo:TXPO_0000819op some obo:OGG_3000415116c

changing abnormal cellular structure [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004757
Super-classes obo:TXPO_0002340c
obo:TXPO_0001770c
Restrictions obo:TXPO_0000069op some obo:TXPO_0005036c
obo:TXPO_0000774op only obo:TXPO_0004280c

liver malfunction [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004758
Super-classes obo:TXPO_0002074c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c

lipid storage in liver [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004759
Super-classes obo:TXPO_0001276c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c

PKC activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004760
Super-classes obo:TXPO_0000023c
Restrictions obo:RO_0002234op some (obo:IMR_0000245c and ub744bL109584C17c)
Sub-classes obo:TXPO_0004761c

PKC activation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004761
Super-classes obo:TXPO_0001987c
obo:TXPO_0004760c
Restrictions obo:RO_0002234op some (obo:IMR_0000245c and ub744bL109605C17c)
obo:TXPO_0000069op some obo:TXPO_0004416c
obo:TXPO_0000774op only obo:TXPO_0001986c

PMAIP1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004762
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000526c and ub744bL109632C17c)
Sub-classes obo:TXPO_0004431c

PMAIP1 - inactive form (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004763
Super-classes obo:TXPO_1000526c
obo:TXPO_0004200c
Restrictions obo:RO_0000086op some obo:PATO_0002355c
obo:TXPO_0000819op some obo:OGG_3000005366c
obo:RO_0000086op some obo:TXPO_0000657c

negative regulation of caspase-3 activation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004764
Super-classes obo:TXPO_0004877c
obo:TXPO_0002340c
Restrictions obo:RO_0002212op some obo:TXPO_0003098c
obo:RO_0000057op some obo:TXPO_0004879c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0000774op only obo:TXPO_0004280c

Increasing PPARA levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004765
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0000159c
Sub-classes obo:TXPO_0004627c

PPARA(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004766
Super-classes obo:TXPO_0000159c
obo:TXPO_0005063c

PPARA(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004767
Super-classes obo:TXPO_0004185c
obo:TXPO_0000159c

Hypofunction of PPARGC1A gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004768
Super-classes obo:TXPO_0002356c
Sub-classes obo:TXPO_0004390c

PPARGC1A (canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004769
Super-classes obo:TXPO_0005127c

PPARA - activation state (mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004770
Super-classes obo:TXPO_0005126c
obo:TXPO_0005072c
Restrictions obo:RO_0000086op some obo:PATO_0002354c

Decreasing PROC levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004771
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:TXPO_0004772c
Sub-classes obo:TXPO_0004773c

PROC (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004772
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004774c

Decreasing PROC level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004773
Super-classes obo:TXPO_0002340c
obo:TXPO_0004771c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004426c
obo:TXPO_0000069op some obo:TXPO_0004427c
obo:RO_0002233op some obo:TXPO_0004774c

PROC (rat)＠肝発癌 [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004774
Super-classes obo:TXPO_0004772c
obo:TXPO_0005070c

PROC gene promoter methylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004775
Super-classes obo:GO_0006306c
Sub-classes obo:TXPO_0004776c

PROC gene promoter methylation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004776
Super-classes obo:TXPO_0004775c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004773c
obo:RO_0002233op some obo:TXPO_0004774c
obo:RO_0000057op some obo:TXPO_0004454c

Increasing PROM1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004777
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004778c
Sub-classes obo:TXPO_0004779c

PROM1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004778
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004780c

Increasing PROM1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004779
Super-classes obo:TXPO_0004777c
obo:TXPO_0002340c
Restrictions obo:RO_0002234op some obo:TXPO_0004780c
obo:TXPO_0000774op only obo:TXPO_0004280c

PROM1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004780
Super-classes obo:TXPO_0004185c
obo:TXPO_0004778c
Sub-classes obo:TXPO_0005129c

Increasing PROX1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004781
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_0004782c
Sub-classes obo:TXPO_0004783c

PROX1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004782
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004784c

Increasing PROX1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004783
Super-classes obo:TXPO_0002340c
obo:TXPO_0004781c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004298c
obo:RO_0002234op some obo:TXPO_0004784c

PROX1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004784
Super-classes obo:TXPO_0004185c
obo:TXPO_0004782c

PTPRD inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004785
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000527c and ub744bL109896C17c)
Sub-classes obo:TXPO_0004693c

PTPRD - inactive form (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004786
Super-classes obo:TXPO_0004186c
obo:TXPO_0004185c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:RO_0000086op some obo:PATO_0002355c

STAT3 activation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004787
Super-classes obo:TXPO_0002340c
obo:TXPO_0004326c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004758c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000069op some obo:TXPO_0004595c

PTPRD gene promoter methylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004788
Super-classes obo:GO_0006306c
Sub-classes obo:TXPO_0004789c

PTPRD gene promoter methylation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004789
Super-classes obo:TXPO_0004788c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004693c
obo:RO_0002233op some obo:TXPO_0004186c
obo:TXPO_0000774op only obo:TXPO_0004280c

Increasing PVT1 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004790
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:OGG_3000005820c
Sub-classes obo:TXPO_0004791c

Increasing PVT1 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004791
Super-classes obo:TXPO_0004790c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004793c
obo:RO_0002234op some obo:TXPO_0004792c

Pvt1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004792
Description

This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis.
Super-classes obo:OGG_3000005820c
obo:TXPO_0004185c

Decreasing MIR150 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004793
Super-classes obo:TXPO_0002340c
obo:TXPO_0004886c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004616c
obo:RO_0002233op some obo:TXPO_0004887c

increasing production quantity of ROS [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004794
Super-classes obo:TXPO_0002340c
obo:TXPO_0000364c
Restrictions obo:RO_0000057op some obo:TXPO_0004513c
obo:TXPO_0000069op some obo:TXPO_0004505c
obo:TXPO_0000774op only obo:TXPO_0004280c

hypofunction of S-adenosylmethionine biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004795
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000716op some obo:GO_0006556c
Sub-classes obo:TXPO_0004796c

hypofunction of S-adenosylmethionine biosynthetic process [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004796
Super-classes obo:TXPO_0001987c
obo:TXPO_0004795c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004797c
obo:TXPO_0000716op some obo:GO_0006556c
obo:TXPO_0000774op only obo:TXPO_0001986c

decreasing glutathione level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004797
Super-classes obo:TXPO_0001987c
obo:TXPO_0004943c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0003569c
obo:TXPO_0000069op some obo:TXPO_0004370c

SFRP1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004798
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_0004799c and ub744bL110107C17c)
Sub-classes obo:TXPO_0004800c

SFRP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004799
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005131c

SFRP1 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004800
Super-classes obo:TXPO_0002340c
obo:TXPO_0004798c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0001868op some obo:TXPO_0004611c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:RO_0002234op some obo:TXPO_0004801c

SFRP1 - inactive form (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004801
Super-classes obo:TXPO_0005131c
obo:TXPO_0004185c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

Increasing SPTLC3 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004802
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000536c
Sub-classes obo:TXPO_0004803c

Increasing SPTLC3 level [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004803
Super-classes obo:TXPO_0002340c
obo:TXPO_0004802c
Restrictions obo:RO_0002234op some obo:TXPO_0004804c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c

SPTLC3 (mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004804
Super-classes obo:TXPO_1000536c
obo:TXPO_0005072c

SRC signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004805
Super-classes obo:TXPO_0000609c

STAT3 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004806
Super-classes obo:TXPO_0000609c

STAT3 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004807
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004806c
Sub-classes obo:TXPO_0004587c

STAT3(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004808
Super-classes obo:TXPO_0004185c
obo:IMR_0000377c
Restrictions obo:RO_0000087op some obo:TXPO_0003724c

positive regulation of cancer stem cell division [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004809
Super-classes obo:TXPO_0004897c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c

Snail1 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004810
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004811c
Sub-classes obo:TXPO_0004395c

Snail1 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004811
Super-classes obo:TXPO_0000609c

SNAI1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004812
Super-classes obo:TXPO_0005132c
obo:TXPO_0004185c

TAZ signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004813
Super-classes obo:TXPO_0000609c

TAZ signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004814
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004813c
obo:RO_0000057op some obo:TXPO_0004815c
Sub-classes obo:TXPO_0004816c

TAZ (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004815
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004817c

TAZ signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004816
Super-classes obo:TXPO_0004814c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004817c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004603c
obo:TXPO_0000069op some obo:TXPO_0004404c
obo:TXPO_0000069op some obo:TXPO_0004403c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0002524op some obo:TXPO_0004813c
obo:TXPO_0000069op some obo:TXPO_0004818c

TAZ (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004817
Super-classes obo:TXPO_0005063c
obo:TXPO_0004815c

Hepatic fibrosis [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004818
Super-classes obo:TXPO_0000816c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:BFO_0000066op some obo:UBERON_0002107c
obo:TXPO_0000774op only obo:TXPO_0004280c

1,4-bis[2-(3,5-dichloropyridyloxy)]benzenec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004819
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0004449c

Hypofunction of TFAM gene expressionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004820
Super-classes obo:TXPO_0002356c
Sub-classes obo:TXPO_0004821c

Hypofunction of TFAM gene expression [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004821
Super-classes obo:TXPO_0004820c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004822c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0000933c

TFAM (canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004822
Super-classes obo:TXPO_0005134c
obo:TXPO_0004293c

TGF-alpha signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004823
Super-classes obo:TXPO_0000609c

TGF-alpha signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004824
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004823c
Sub-classes obo:TXPO_0004825c

TGF-alpha signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004825
Super-classes obo:TXPO_0002340c
obo:TXPO_0004824c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004823c
obo:RO_0000057op some obo:TXPO_0004826c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004526c

TGFA (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004826
Super-classes obo:TXPO_0005063c
obo:TXPO_0005135c

TGFB1(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004827
Super-classes obo:TXPO_1000371c
obo:IMR_0000042c
obo:TXPO_0005063c
Restrictions obo:TXPO_0002260op some obo:IMR_0000041c

regulatory T cell migration [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004828
Super-classes obo:TXPO_0002340c
obo:TXPO_0005020c
Restrictions obo:TXPO_0000069op some obo:TXPO_0005019c
obo:TXPO_0000774op only obo:TXPO_0004280c

TLR4 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004829
Super-classes obo:TXPO_0004301c
Restrictions obo:TXPO_0001868op some obo:IMR_0001440c
obo:TXPO_0002524op some obo:GO_0034142c
Sub-classes obo:TXPO_0004378c

cytolysis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004830
Super-classes obo:TXPO_0001987c
obo:GO_0019835c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op some obo:CL_0000000c
obo:TXPO_0000069op some obo:TXPO_0001992c
obo:TXPO_0000069op some obo:TXPO_0004342c

TLR4 (canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004831
Super-classes obo:IMR_0001440c
obo:TXPO_0004293c

TNF signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004832
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:GO_0033209c
Sub-classes obo:TXPO_0004833c
obo:TXPO_0004834c

TNF signaling [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004833
Super-classes obo:TXPO_0004832c
obo:TXPO_0001987c
Restrictions obo:RO_0000057op some obo:TXPO_0004381c
obo:TXPO_0000069op some obo:TXPO_0004397c
obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0002524op some obo:GO_0033209c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:TXPO_0000774op only obo:TXPO_0001986c

TNF signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004834
Super-classes obo:TXPO_0004832c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004835c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004661c
obo:TXPO_0002524op some obo:GO_0033209c

TNFΑ(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004835
Super-classes obo:TXPO_1000374c
obo:TXPO_0005063c

MTOR (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004836
Super-classes obo:TXPO_0005063c
obo:TXPO_0004020c

response to hypoxia [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004837
Super-classes obo:GO_0001666c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004847c
obo:TXPO_0000069op some obo:TXPO_0004557c
obo:TXPO_0000069op some obo:TXPO_0004630c
obo:TXPO_0000069op some obo:TXPO_0004598c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0005016c

TSLC signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004838
Super-classes obo:TXPO_0000609c

TSLC signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004839
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004838c

negative regulation of TSLC signalingc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004840
Super-classes obo:GO_0023057c
Restrictions obo:RO_0002212op some obo:TXPO_0004839c
obo:RO_0002212op some obo:TXPO_0004838c
Sub-classes obo:TXPO_0004841c

negative regulation of TSLC signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004841
Super-classes obo:TXPO_0002340c
obo:TXPO_0004840c
Restrictions obo:RO_0000057op some obo:TXPO_0004842c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002212op some obo:TXPO_0004839c
obo:RO_0000057op some obo:TXPO_0004704c
obo:RO_0002212op some obo:TXPO_0004838c
obo:TXPO_0000069op some obo:TXPO_0004844c
obo:RO_0000057op some obo:TXPO_0004843c
obo:TXPO_0000069op some obo:TXPO_0004845c

CADM1 (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004842
Super-classes obo:TXPO_0005070c
obo:TXPO_0005069c

EPB41L3 (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004843
Super-classes obo:TXPO_0005079c
obo:TXPO_0005070c

negative regulation of actin cytoskeleton organization [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004844
Super-classes obo:TXPO_0004903c
obo:TXPO_0002340c
Restrictions obo:RO_0002212op some obo:GO_0030036c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:TXPO_0000069op some obo:TXPO_0004404c

Negative regulation of adherens junction assembly [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004845
Description

TSLC1 and DAL‐1 are components of the TSLC cascade, which participates in organizing the actin cytoskeleton and constructing stable cell‐to‐cell adhesion. It is thought that disturbances in the cell adhesion system are critical factors in the growth, invasion and metastasis of cancer cells.
Super-classes obo:TXPO_0003813c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004479c
obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000069op some obo:TXPO_0004404c

Twist1 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004846
Super-classes obo:TXPO_0000609c

Twist1 signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004847
Super-classes obo:TXPO_0002340c
obo:TXPO_0004848c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004846c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004849c

Twist1 signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004848
Super-classes obo:GO_0023052c
Restrictions obo:RO_0000057op some obo:TXPO_1000380c
obo:TXPO_0002524op some obo:TXPO_0004846c
Sub-classes obo:TXPO_0004847c

TWIST1(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004849
Super-classes obo:TXPO_1000380c
obo:TXPO_0000837c

trimeric UHRF1 repression complexc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004850
Super-classes obo:TXPO_0002107c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
Sub-classes obo:TXPO_0004611c

DNMT1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004851
Super-classes obo:TXPO_0004521c
obo:TXPO_0004185c

USP7 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004852
Super-classes obo:TXPO_0005136c
obo:TXPO_0004185c

UHRF1 inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004853
Super-classes obo:TXPO_0000021c
Restrictions obo:RO_0002234op some (obo:TXPO_1000547c and ub744bL110837C17c)
Sub-classes obo:TXPO_0004854c

UHRF1 inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004854
Super-classes obo:TXPO_0002340c
obo:TXPO_0004853c
Restrictions obo:RO_0002234op some obo:TXPO_0004855c
obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000069op some obo:TXPO_0004487c
obo:TXPO_0000774op only obo:TXPO_0004280c

UHRF1 - inactive form (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004855
Super-classes obo:TXPO_0004203c
obo:TXPO_0004185c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029128c
obo:RO_0000086op some obo:PATO_0002355c
obo:RO_0000086op some obo:TXPO_0000657c

Increasing VEGF levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004856
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op some obo:TXPO_1000502c
Sub-classes obo:TXPO_0004413c

VEGF (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004857
Super-classes obo:IMR_0000031c
obo:TXPO_0004185c
Restrictions obo:RO_0000087op some obo:TXPO_0000624c
obo:RO_0000087op some obo:TXPO_0002395c

VEGF (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004858
Super-classes obo:IMR_0000031c
obo:TXPO_0004185c
Restrictions obo:RO_0000087op some obo:TXPO_0002395c
obo:RO_0000087op some obo:TXPO_0000624c

WNT signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004859
Super-classes obo:TXPO_0000609c

WNT signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004860
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004859c
obo:RO_0000057op some obo:IMR_0000003c
Sub-classes obo:TXPO_0004557c

FZD1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004861
Super-classes obo:TXPO_0005081c
obo:TXPO_0005063c

FZD2 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004862
Super-classes obo:TXPO_0005082c
obo:TXPO_0005063c

FZD5 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004863
Super-classes obo:TXPO_0005063c
obo:TXPO_0005083c

FZD6 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004864
Super-classes obo:TXPO_0005084c
obo:TXPO_0005063c

FZD7 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004865
Super-classes obo:TXPO_0005085c
obo:TXPO_0005063c

FZD9 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004866
Super-classes obo:TXPO_0005086c
obo:TXPO_0005063c

YAP signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004867
Super-classes obo:TXPO_0000609c

YAP signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004868
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004867c
obo:RO_0000057op some obo:TXPO_0005137c
Sub-classes obo:TXPO_0004640c

YAP1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004869
Super-classes obo:TXPO_0005063c
obo:TXPO_0005137c

beta-catenin signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004870
Super-classes obo:TXPO_0000609c

beta-catenin signal (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004871
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004870c
Sub-classes obo:TXPO_0004577c

CDH1 - inactive form (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004872
Super-classes obo:TXPO_0005073c
obo:TXPO_0005063c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

Ctnnb1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004873
Super-classes obo:TXPO_1000094c
obo:TXPO_0005063c

actin cytoskeleton reorganization [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004874
Super-classes obo:TXPO_0002340c
obo:GO_0031532c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004422c
obo:TXPO_0000774op only obo:TXPO_0004280c

c-Src signaling (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004875
Super-classes obo:GO_0023052c
Restrictions obo:RO_0000057op some obo:IMR_0100575c
obo:TXPO_0002524op some obo:TXPO_0004805c
Sub-classes obo:TXPO_0004589c

Src (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004876
Super-classes obo:IMR_0100575c

negative regulation of caspase-3 activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004877
Super-classes obo:TXPO_0004878c
Restrictions obo:RO_0002212op some obo:TXPO_0003098c
Sub-classes obo:TXPO_0004764c

negative regulation of activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004878
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0000401c
Sub-classes obo:TXPO_0004877c

CASPASE-3(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004879
Super-classes obo:TXPO_0004185c
obo:TXPO_0001145c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000836c
obo:TXPO_0002260op some obo:IMR_0000305c

cytoplasmic sequestering of cyclin Ac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004880
Super-classes obo:TXPO_0000433c
Sub-classes obo:TXPO_0004881c

cytoplasmic sequestering of cyclin A [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004881
Super-classes obo:TXPO_0002340c
obo:TXPO_0004880c
Restrictions obo:RO_0000057op some obo:TXPO_0004187c
obo:TXPO_0000069op some obo:TXPO_0004883c
obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000069op some obo:TXPO_0004882c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004512c
obo:TXPO_0000069op some obo:TXPO_0004633c

Malfunctioning of centrosome duplication [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004882
Super-classes obo:TXPO_0002340c
obo:TXPO_0005015c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c

Malfunctioning of cytokinesis [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004883
Super-classes obo:TXPO_0005033c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004392c
obo:TXPO_0000774op only obo:TXPO_0004280c

inducible nitric oxide synthase productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004884
Super-classes obo:TXPO_0005048c
Sub-classes obo:TXPO_0004383c

NOS2 (canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004885
Super-classes obo:TXPO_0005119c
obo:TXPO_0004293c

Decreasing miR-150 levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004886
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:OGG_3000406942c
Sub-classes obo:TXPO_0004793c

MIR150 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004887
Super-classes obo:OGG_3000406942c
obo:TXPO_0004185c

mitochondria morphology changec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004888
Super-classes obo:TXPO_0000410c
Sub-classes obo:TXPO_0004998c
obo:TXPO_0004350c

TP53(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004889
Super-classes obo:TXPO_0004185c
obo:IMR_0100659c

proto-oncogene mutationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004890
Super-classes obo:TXPO_0001985c
Sub-classes obo:TXPO_0004506c

7,12-dimethyltetraphene [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004891
Super-classes obo:TXPO_0004455c
obo:CHEBI_254496c

4-(phenylazo)aniline [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004892
Super-classes obo:CHEBI_233869c
obo:TXPO_0004455c

HRAS (mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004893
Super-classes obo:TXPO_0005072c
obo:IMR_0000695c

KRAS (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004894
Super-classes obo:IMR_0000291c

KRAS (mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004895
Super-classes obo:TXPO_0005072c
obo:IMR_0000291c

NRAS (mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004896
Super-classes obo:TXPO_0005072c
obo:IMR_0000696c

positive regulation of cancer stem cell divisionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004897
Super-classes obo:GO_0051781c
Sub-classes obo:TXPO_0004809c

cancer stem-like cell proliferationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004898
Super-classes obo:GO_0008283c
Restrictions obo:RO_0002234op some (ub744bL111303C33c and ub744bL111313C17c)
Sub-classes obo:TXPO_0004899c

Cancer-stem like cell proliferation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004899
Super-classes obo:TXPO_0004898c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some (ub744bL111333C33c and ub744bL111343C17c)
obo:TXPO_0000069op some obo:TXPO_0004557c

tumor suppressor inactivationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004900
Super-classes obo:TXPO_0000021c
Sub-classes obo:TXPO_0004901c

Tumor suppressor inactivation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004901
Super-classes obo:TXPO_0004900c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:BFO_0000051op some obo:TXPO_0004683c
obo:BFO_0000051op some obo:TXPO_0004402c
obo:BFO_0000051op some obo:TXPO_0004693c
obo:BFO_0000051op some obo:TXPO_0004431c
obo:BFO_0000051op some obo:TXPO_0004738c
obo:BFO_0000051op some obo:TXPO_0004507c
obo:BFO_0000051op some obo:TXPO_0004841c
obo:BFO_0000051op some obo:TXPO_0004789c
obo:BFO_0000051op some obo:TXPO_0004749c

Tumor suppressor gene mutationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004902
Super-classes obo:TXPO_0001985c
Sub-classes obo:TXPO_0004507c

negative regulation of actin cytoskeleton organizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004903
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0030036c
Sub-classes obo:TXPO_0004844c

acetyl-CoA biosynthetic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004904
Super-classes obo:TXPO_0000019c
Restrictions obo:RO_0002234op some obo:CHEBI_73693c

decreasing adiponectin levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004905
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0004906c

decreasing adiponectin level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004906
Super-classes obo:TXPO_0001987c
obo:TXPO_0004905c
Restrictions obo:TXPO_0000069op some obo:TXPO_0000869c
obo:TXPO_0000774op only obo:TXPO_0001986c

aflatoxin B1 [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004907
Super-classes obo:TXPO_0004455c
obo:CHEBI_2504c

aflatoxin metabolic process [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004908
Super-classes obo:TXPO_0002340c
obo:GO_0046222c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004507c
obo:TXPO_0001868op some obo:TXPO_0004915c
obo:TXPO_0001868op some obo:TXPO_0004914c
obo:TXPO_0001868op some obo:TXPO_0004913c
obo:TXPO_0001868op some obo:TXPO_0004912c
obo:TXPO_0001868op some obo:TXPO_0004911c
obo:TXPO_0001868op some obo:TXPO_0004910c
obo:TXPO_0001868op some obo:TXPO_0004916c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002233op some obo:TXPO_0004907c
obo:RO_0002234op some obo:TXPO_0004909c

aflatoxin B1 exo-8,9-epoxide [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004909
Super-classes obo:TXPO_0004455c
obo:CHEBI_30725c

CYP1A2(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004910
Super-classes obo:TXPO_0005063c
obo:TXPO_0003633c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001544c

CYP2A13 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004911
Super-classes obo:TXPO_0005063c
obo:TXPO_0005076c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001553c

CYP2A6 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004912
Super-classes obo:TXPO_0005077c
obo:TXPO_0005063c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001548c

CYP3A4(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004913
Super-classes obo:TXPO_0005063c
obo:TXPO_1000082c

CYP3A5(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004914
Super-classes obo:TXPO_1000083c
obo:TXPO_0005063c

CYP3A7 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004915
Super-classes obo:TXPO_0005063c
obo:TXPO_0005078c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001551c

Cyp1A1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004916
Super-classes obo:TXPO_0005063c
obo:TXPO_1000100c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001543c

BCL2 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004917
Super-classes obo:TXPO_0005063c
obo:TXPO_1000041c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000596c

CCND1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004918
Super-classes obo:TXPO_0005063c
obo:TXPO_1000088c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000595c

tumor cell survial [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004919
Super-classes obo:TXPO_0000280c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c

positive regulation of arachidonic acid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004920
Super-classes obo:TXPO_0001223c
Restrictions obo:RO_0002213op some obo:TXPO_0003884c
Sub-classes obo:TXPO_0004410c

Decreasing arachidonic acid levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004921
Super-classes obo:TXPO_0000396c
Restrictions obo:RO_0002233op some obo:TXPO_0001166c

aristolochic acid [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004922
Super-classes obo:CHEBI_2825c
obo:TXPO_0004455c

alcohol intake [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004923
Super-classes obo:TXPO_0002340c
obo:TXPO_0001224c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004506c
obo:RO_0002233op some obo:TXPO_0004924c
obo:TXPO_0000069op some obo:TXPO_0004453c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004630c

alcohol [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004924
Super-classes obo:CHEBI_30879c
obo:TXPO_0004455c

NLRP3 (canonical)[mitochondrial disorder]]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004925
Super-classes obo:TXPO_0001877c
obo:TXPO_0003516c

hypofunction of oxysterol biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004926
Super-classes obo:TXPO_0002195c
Restrictions obo:TXPO_0000716op some obo:GO_0006695c
obo:TXPO_0000069op some obo:TXPO_0001330c
Sub-classes obo:TXPO_0004927c

hypofunction of oxysterol biosynthesis [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004927
Super-classes obo:TXPO_0004926c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

autophagy [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004928
Super-classes obo:GO_0006914c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

autophagy [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004929
Super-classes obo:TXPO_0002340c
obo:GO_0006914c
Restrictions obo:RO_0000057op some obo:TXPO_0004193c
obo:TXPO_0000069op some obo:TXPO_0004518c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0004930c

BECN1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004930
Super-classes obo:TXPO_0005068c
obo:TXPO_0004185c

cardiolipin peroxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004931
Super-classes obo:TXPO_0004932c
Restrictions obo:RO_0002233op some obo:CHEBI_28494c
Sub-classes obo:TXPO_0004341c

phospholipid peroxidationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004932
Super-classes obo:TXPO_0003514c
Sub-classes obo:TXPO_0005009c
obo:TXPO_0004931c

negative regulation of phospholipid degradation [Phospholipidosis (latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004933
Super-classes obo:TXPO_0000905c
Restrictions obo:TXPO_0000069op some obo:TXPO_0005059c
obo:BFO_0000051op some obo:TXPO_0001908c
obo:TXPO_0000774op only obo:TXPO_0001964c

Chlorendic Acid [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004934
Super-classes obo:TXPO_0004455c
obo:CHEBI_76603c

Increasing glucagon levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004935
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004936c

Increasing glucagon level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004936
Super-classes obo:TXPO_0004935c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004366c

glucose homeostasis imbalance [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004937
Super-classes obo:TXPO_0001233c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004379c

increasing glucose levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004938
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004939c

increasing glucose level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004939
Super-classes obo:TXPO_0001987c
obo:TXPO_0004938c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004350c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001988c
obo:TXPO_0000069op some obo:TXPO_0001993c
obo:TXPO_0000069op some obo:TXPO_0001990c

decreasing glucose levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004940
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0004941c

Decreasing glucose level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004941
Super-classes obo:TXPO_0004940c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001992c
obo:TXPO_0000774op only obo:TXPO_0001986c

hyperfunction of gluconeogenesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004942
Super-classes obo:TXPO_0002346c
Restrictions obo:TXPO_0001502op some obo:GO_0006094c
Sub-classes obo:TXPO_0004367c

decreasing glutathione levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004943
Super-classes obo:TXPO_0000396c
Sub-classes obo:TXPO_0004797c

Negative regulation of glutathione transportc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004944
Super-classes obo:TXPO_0002682c
Sub-classes obo:TXPO_0004984c

Increasing ketone body levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004945
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004946c

Increasing ketone body level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004946
Super-classes obo:TXPO_0001987c
obo:TXPO_0004945c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004366c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002234op some obo:CHEBI_73693c

induction of genomic instabilityc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004947
Super-classes obo:TXPO_0001984c
Sub-classes obo:TXPO_0004512c

gemfibrozil [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004948
Super-classes obo:CHEBI_5296c
()
obo:TXPO_0004455c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9989c

Connexin signaling (primitive) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004949
Super-classes obo:TXPO_0002340c
obo:TXPO_0004495c
Restrictions obo:TXPO_0002524op some obo:TXPO_0004494c
obo:RO_0000057op some obo:TXPO_0004950c
obo:RO_0000057op some obo:TXPO_0004951c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004526c

GJB1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004950
Super-classes obo:TXPO_0004185c
obo:TXPO_0005088c

Src (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004951
Super-classes obo:TXPO_0004185c
obo:IMR_0100575c

negative regulation of connexin signaling [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004952
Super-classes obo:TXPO_0004496c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004950c
obo:RO_0000057op some obo:TXPO_0004953c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002212op some obo:TXPO_0004494c
obo:TXPO_0000069op some obo:TXPO_0004538c
obo:RO_0002212op some obo:TXPO_0004495c

GJA1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004953
Super-classes obo:TXPO_0005087c
obo:TXPO_0004185c

Increasing cholesterol levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004954
Super-classes obo:TXPO_0001062c
Sub-classes obo:TXPO_0004955c

Increasing cholesterol level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004955
Super-classes obo:TXPO_0004954c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004956c
obo:TXPO_0000774op only obo:TXPO_0001986c

Increasing triol level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004956
Super-classes obo:TXPO_0004968c
obo:TXPO_0001987c
Restrictions obo:RO_0002234op only obo:CHEBI_27136c
obo:TXPO_0000069op some obo:TXPO_0001992c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0000869c

cisplatin resistancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004957
Super-classes obo:TXPO_0004958c
Sub-classes obo:TXPO_0004579c

drug resistancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004958
Super-classes obo:TXPO_0000157c
Sub-classes obo:TXPO_0004957c
obo:TXPO_0004965c

diacylglycerol acumulationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004959
Super-classes obo:GO_0019915c
Restrictions obo:RO_0002233op some obo:IMR_0100027c
Sub-classes obo:TXPO_0004960c

diacylglycerol accumulation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004960
Super-classes obo:TXPO_0001987c
obo:TXPO_0004959c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004761c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002233op some obo:IMR_0100027c

styrene oxide [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004961
Super-classes obo:CHEBI_17907c
obo:TXPO_0004455c

Negative regulation of sphingolipid metabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004962
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006665c
Sub-classes obo:TXPO_0004963c

Negative regulation of sphingolipid metabolic process [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004963
Super-classes obo:TXPO_0004962c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004516c
obo:RO_0002212op some obo:GO_0006665c
obo:TXPO_0000069op some obo:TXPO_0004396c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004403c

ceramide accumulation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004964
Super-classes obo:TXPO_0004143c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004761c
obo:TXPO_0000774op only obo:TXPO_0001986c

sorafenib resistance (process)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004965
Super-classes obo:TXPO_0004958c
Sub-classes obo:TXPO_0004529c

Telomerase reverse transcriptase gene mutationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004966
Super-classes obo:TXPO_0001985c
Sub-classes obo:TXPO_0004590c

TERT (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004967
Super-classes obo:TXPO_0005133c
obo:TXPO_0005063c

Increasing triol levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004968
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op only obo:CHEBI_27136c
Sub-classes obo:TXPO_0004956c

Methapyrilene hydrochloride [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004969
Super-classes obo:CHEBI_38213c
obo:TXPO_0004455c

panadiplonc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004970
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_35474c
Sub-classes obo:TXPO_0004363c

pyrethrins [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004971
Super-classes obo:CHEBI_39098c
()
obo:TXPO_0004455c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_9989c

fialuridinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004972
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_36044c
Sub-classes obo:TXPO_0004389c

Increasing fructose levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004973
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op only obo:CHEBI_28757c
Sub-classes obo:TXPO_0004974c

Increasing fructose level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004974
Super-classes obo:TXPO_0001987c
obo:TXPO_0004973c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004372c
obo:TXPO_0000069op some obo:TXPO_0004121c
obo:TXPO_0000069op some obo:TXPO_0002005c
obo:RO_0002234op only obo:CHEBI_28757c
obo:TXPO_0000069op some obo:TXPO_0004975c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004976c
obo:TXPO_0000069op some obo:TXPO_0004373c
obo:TXPO_0000069op some obo:TXPO_0001988c

Hypofunction of mitochondrial repair [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004975
Super-classes obo:TXPO_0001987c
obo:TXPO_0004988c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op only obo:GO_0005739c

Increasing uric acid level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004976
Super-classes obo:TXPO_0005027c
obo:TXPO_0001987c
Restrictions obo:RO_0002234op only obo:CHEBI_27226c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004373c

nagative regulation of mitophagyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004977
Super-classes obo:GO_1901524c
Restrictions obo:RO_0002213op some obo:GO_0000423c
Sub-classes obo:TXPO_0004359c

macrophage migration [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004978
Super-classes obo:TXPO_0001987c
obo:GO_1905517c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004249c
obo:TXPO_0000774op only obo:TXPO_0001986c

malondialdehyde [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004979
Super-classes obo:CHEBI_566274c
obo:TXPO_0004312c

disruption of ER-mitochondria contact sitesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004980
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:TXPO_0000192c
Sub-classes obo:TXPO_0004981c

Disruption of ER-mitochondria contact sites [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004981
Super-classes obo:TXPO_0001987c
obo:TXPO_0004980c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004937c

increasing mtDNA levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004982
Super-classes obo:TXPO_0000395c

glutathione transport from cytoplasm into mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004983
Super-classes obo:GO_0034635c
Restrictions obo:RO_0002339op only obo:GO_0005739c
obo:RO_0002338op some obo:GO_0005737c

Negative regulation of glutathione transport into mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004984
Super-classes obo:TXPO_0004944c
Sub-classes obo:TXPO_0004985c

Negative regulation of glutathione transport into mitochondria [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004985
Super-classes obo:TXPO_0001987c
obo:TXPO_0004984c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004797c

long-chain fatty acid import into mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004986
Super-classes obo:GO_0015909c
Sub-classes obo:TXPO_0004987c

long-chain fatty acid import into mitochondria [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004987
Super-classes obo:TXPO_0004986c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0002041c
obo:TXPO_0001868op some obo:TXPO_0004474c

Hypofunction of mitochondrial repairc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004988
Super-classes obo:TXPO_0000436c
Restrictions obo:BFO_0000066op only obo:GO_0005739c
Sub-classes obo:TXPO_0004975c

Increase in mitochondrial calcium levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004989
Super-classes obo:TXPO_0000353c
Sub-classes obo:TXPO_0004990c

Increase in mitochondrial calcium level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004990
Super-classes obo:TXPO_0001987c
obo:TXPO_0004989c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001991c

mitochondrial cholesterol storagec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004991
Super-classes obo:GO_0010878c
Restrictions obo:BFO_0000066op only obo:GO_0005764c
Sub-classes obo:TXPO_0004992c

mitochondrial cholesterol storage [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004992
Super-classes obo:TXPO_0001987c
obo:TXPO_0004991c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004833c
obo:TXPO_0000069op some obo:TXPO_0004249c
obo:TXPO_0000069op some obo:TXPO_0004985c
obo:TXPO_0000069op some obo:TXPO_0004351c
obo:TXPO_0000069op some obo:TXPO_0004927c
obo:TXPO_0000069op some obo:TXPO_0004549c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:BFO_0000066op only obo:GO_0005739c

Negative regulation of mitochondrial respiratory chain complex I subunit phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004993
Super-classes obo:TXPO_0004994c
Restrictions obo:RO_0002212op some obo:TXPO_0004995c
Sub-classes obo:TXPO_0004375c

negative regulation of phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004994
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0016310c
Sub-classes obo:TXPO_0004993c

mitochondrial respiratory chain complex I subunit phosphorylationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004995
Super-classes obo:GO_0016310c
Restrictions obo:RO_0002233op some obo:TXPO_0004329c

mitochondrial dysfunction [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004996
Super-classes obo:TXPO_0002340c
obo:TXPO_0002361c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004541c
obo:TXPO_0000069op some obo:TXPO_0004794c

dysregulation of mitochondrion organizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004997
Super-classes obo:TXPO_0000532c
Sub-classes obo:TXPO_0004444c

mitochondrial membrane morphology changesc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004998
Super-classes obo:TXPO_0004888c
Sub-classes obo:TXPO_0004345c

Increasing mitochondrial membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0004999
Super-classes obo:TXPO_0005000c
Restrictions obo:BFO_0000066op only obo:GO_0031966c

Increasing membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005000
Super-classes obo:TXPO_0001456c
Restrictions obo:TXPO_0000531op some obo:TXPO_0005041c
Sub-classes obo:TXPO_0004445c
obo:TXPO_0004999c

metalloprotease activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005001
Super-classes obo:TXPO_0000401c
Sub-classes obo:TXPO_0004421c

MMP2(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005002
Super-classes obo:TXPO_0005063c
obo:TXPO_1000238c

MMP9(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005003
Super-classes obo:TXPO_0005063c
obo:TXPO_1000239c

Negative regulation of methionine metabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005004
Super-classes obo:TXPO_0000369c
Restrictions obo:RO_0002212op some obo:GO_0006555c
Sub-classes obo:TXPO_0005005c

Negative regulation of methionine metabolic process [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005005
Super-classes obo:TXPO_0005004c
obo:TXPO_0002340c
Restrictions obo:RO_0002212op some obo:GO_0006555c
obo:RO_0000057op some obo:TXPO_0005006c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0000057op some obo:TXPO_0005007c
obo:RO_0000057op some obo:TXPO_0004454c
obo:TXPO_0000069op some obo:TXPO_0004392c

MTAP (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005006
Super-classes obo:TXPO_0004185c
obo:TXPO_0005103c

MTAP (rat) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005007
Super-classes obo:TXPO_0005070c
obo:TXPO_0005103c

Monuron [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005008
Super-classes obo:TXPO_0004455c
obo:CHEBI_38214c

phospholipid peroxidation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005009
Super-classes obo:TXPO_0004932c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0001991c

lipoperoxidation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005010
Super-classes obo:TXPO_0003514c
obo:TXPO_0002340c
Restrictions obo:RO_0000057op some obo:TXPO_0004704c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:RO_0002234op some obo:TXPO_0004502c
obo:RO_0000057op some obo:TXPO_0004516c
obo:TXPO_0000069op some obo:TXPO_0004392c

redox changec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005011
Super-classes obo:TXPO_0001984c
Sub-classes obo:TXPO_0004351c

increasing leptin levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005012
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0005013c

increasing leptin level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005013
Super-classes obo:TXPO_0001987c
obo:TXPO_0005012c
Restrictions obo:TXPO_0000069op some obo:TXPO_0002041c
obo:TXPO_0000774op only obo:TXPO_0001986c

tumor malignancy alteration [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005014
Super-classes obo:TXPO_0002340c
obo:TXPO_0005040c
Restrictions obo:BFO_0000051op some obo:TXPO_0004404c
obo:BFO_0000051op some obo:TXPO_0004479c
obo:TXPO_0000774op only obo:TXPO_0004280c

malfunctioning of centrosome duplicationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005015
Super-classes obo:TXPO_0000434c
Sub-classes obo:TXPO_0004882c

HIF1A(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005016
Super-classes obo:TXPO_0005063c
obo:TXPO_0004613c

hypoxia [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005017
Description

PMID:31781608
Super-classes obo:TXPO_0002340c
obo:MP_0005039c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004753c
obo:TXPO_0000069op some obo:TXPO_0004837c
obo:TXPO_0000069op some obo:TXPO_0004640c
obo:TXPO_0000069op some obo:TXPO_0004854c
obo:TXPO_0000069op some obo:TXPO_0004557c
obo:TXPO_0000069op some obo:TXPO_0004825c

dysregulation of immune balancec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005018
Super-classes obo:TXPO_0000532c
Sub-classes obo:TXPO_0004592c

hypofunction of immune response to tumor cell [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005019
Super-classes obo:TXPO_0005028c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000716op some obo:GO_0002418c
obo:TXPO_0000069op some obo:TXPO_0004919c
obo:TXPO_0000774op only obo:TXPO_0004280c

regulatory T cell migrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005020
Super-classes obo:GO_0050900c
Sub-classes obo:TXPO_0004828c

protooncogene activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005021
Super-classes obo:TXPO_0000023c
Sub-classes obo:TXPO_0005022c

protooncogene activation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005022
Super-classes obo:TXPO_0005021c
obo:TXPO_0002340c
Restrictions obo:BFO_0000051op some obo:TXPO_0004673c
obo:BFO_0000051op some obo:TXPO_0004506c
obo:BFO_0000051op some obo:TXPO_0004681c
obo:BFO_0000051op some obo:TXPO_0004791c
obo:BFO_0000051op some obo:TXPO_0004669c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:BFO_0000051op some obo:TXPO_0004698c
obo:BFO_0000051op some obo:TXPO_0004590c
obo:BFO_0000051op some obo:TXPO_0004703c

increasing production amount of reactive aldehydec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005023
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004393c

reactive aldehyde [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005024
Super-classes obo:TXPO_0003603c
obo:TXPO_0004328c

4-hydroxynonenal [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005025
Super-classes obo:CHEBI_142593c
obo:TXPO_0004312c

response to endoplasmic reticulum stress [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005026
Super-classes obo:TXPO_0002340c
obo:GO_0034976c
Restrictions obo:BFO_0000051op some obo:TXPO_0004434c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:BFO_0000051op some obo:TXPO_0004432c

Increasing uric acid levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005027
Super-classes obo:TXPO_0000395c
Restrictions obo:RO_0002234op only obo:CHEBI_27226c
Sub-classes obo:TXPO_0004976c

hypofunction of immune response to tumor cellc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005028
Super-classes obo:TXPO_0000436c
Restrictions obo:TXPO_0000716op some obo:GO_0002418c
Sub-classes obo:TXPO_0005019c

negative regulation of antioxidant enzyme activationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005029
Super-classes obo:TXPO_0001787c
Sub-classes obo:TXPO_0004722c

increasing damaged mitochondriac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005030
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004368c

release of inflammatory DAMPs [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005031
Super-classes obo:TXPO_0001987c
obo:TXPO_0005139c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004340c
obo:BFO_0000066op some obo:GO_0005739c
obo:TXPO_0000069op some obo:TXPO_0004253c

negative regulation of ROS formation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005032
Super-classes obo:TXPO_0002340c
obo:GO_1903427c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004431c
obo:RO_0002212op some obo:GO_1903409c
obo:TXPO_0000774op only obo:TXPO_0004280c

malfunctioning of cytokinesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005033
Super-classes obo:TXPO_0000434c
Sub-classes obo:TXPO_0004883c

increasing blood glucose level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005034
Super-classes obo:TXPO_0001987c
obo:TXPO_0001912c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

cellular damage [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005035
Super-classes obo:TXPO_0000225c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004818c
obo:TXPO_0000069op some obo:TXPO_0004392c

nodule formation [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005036
Super-classes obo:TXPO_0000612c
obo:TXPO_0002340c
Restrictions obo:TXPO_0000774op only obo:TXPO_0004280c
obo:TXPO_0000069op some obo:TXPO_0004392c

hepatocyte regenerationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005037
Super-classes obo:GO_0042246c
Sub-classes obo:TXPO_0004593c

Increasing lipid [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005038
Super-classes obo:TXPO_0002340c
obo:TXPO_0001062c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004803c
obo:TXPO_0000774op only obo:TXPO_0004280c

increasing lipid concentration [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005039
Super-classes obo:TXPO_0005043c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c

tumor malignancy alterationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005040
Super-classes obo:TXPO_0005141c
Restrictions obo:TXPO_0000531op some obo:PATO_0002097c
Sub-classes obo:TXPO_0005014c

increased membrane potentialc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005041
Super-classes (obo:TXPO_0002420c and ub744bL113204C13c)
obo:PATO_0001462c

Increasing cholesterol concentration in bloodc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005042
Super-classes obo:TXPO_0005043c
Sub-classes obo:TXPO_0005044c

increasing lipid concentrationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005043
Super-classes obo:TXPO_0000352c
Sub-classes obo:TXPO_0005042c
obo:TXPO_0005039c

Increasing cholesterol concentration in blood [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005044
Super-classes obo:TXPO_0001987c
obo:TXPO_0005042c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001988c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004373c
obo:TXPO_0000069op some obo:TXPO_0001993c
obo:TXPO_0000069op some obo:TXPO_0004350c
obo:TXPO_0000069op some obo:TXPO_0002004c

endothelial progenitor cell mobilizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005045
Super-classes obo:GO_0016477c
Sub-classes obo:TXPO_0004483c

neovascularizationc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005046
Super-classes obo:TXPO_0000134c

KDR (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005047
Super-classes obo:TXPO_0005096c
obo:TXPO_0005063c

enzyme productionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005048
Super-classes obo:TXPO_0000382c
Sub-classes obo:TXPO_0004884c

TP53(canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005049
Super-classes obo:IMR_0100659c
obo:TXPO_0005063c

iron metabolic dysfunctionc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005050
Super-classes obo:TXPO_0002131c
Sub-classes obo:TXPO_0005051c

iron metabolic dysfunction [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005051
Super-classes obo:TXPO_0002340c
obo:TXPO_0005050c
Restrictions obo:BFO_0000051op some obo:TXPO_0004661c
obo:TXPO_0000774op only obo:TXPO_0004280c
obo:BFO_0000051op some obo:TXPO_0004617c

Increasing iron uptake levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005052
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0004617c

hypofunction of heme biosynthesisc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005053
Super-classes obo:TXPO_0001910c
Restrictions obo:TXPO_0000716op some obo:GO_0006783c
Sub-classes obo:TXPO_0004561c

Increasing long-chain free fatty acid levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005054
Super-classes obo:TXPO_0000395c
Sub-classes obo:TXPO_0005055c

Increasing long-chain free fatty acid level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005055
Super-classes obo:TXPO_0005054c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0001990c
obo:TXPO_0000774op only obo:TXPO_0001986c

increasing saturated fatty acid levelc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005056
Super-classes obo:TXPO_0001062c
Sub-classes obo:TXPO_0005057c

Increasing saturated fatty acid level [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005057
Super-classes obo:TXPO_0001987c
obo:TXPO_0005056c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004960c
obo:TXPO_0000069op some obo:TXPO_0002004c
obo:RO_0002234op some obo:TXPO_0005058c
obo:TXPO_0000069op some obo:TXPO_0001988c
obo:TXPO_0000069op some obo:TXPO_0000933c
obo:TXPO_0000069op some obo:TXPO_0004225c
obo:TXPO_0000069op some obo:TXPO_0004964c
obo:TXPO_0000069op some obo:TXPO_0001990c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004271c
obo:TXPO_0000069op some obo:TXPO_0004373c

saturated fatty acid [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005058
Super-classes obo:TXPO_0004312c
obo:CHEBI_26607c

hypofunction of phospholipid degradation [Phospholipidosis(latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005059
Super-classes obo:TXPO_0000925c
Restrictions obo:TXPO_0000716op some obo:TXPO_0001406c
obo:RO_0000057op some obo:TXPO_0001804c
obo:TXPO_0000774op only obo:TXPO_0001964c
obo:TXPO_0000069op some obo:TXPO_0002293c
obo:RO_0000057op some obo:TXPO_0000775c

1,2-dichloropropane [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005060
Super-classes obo:TXPO_0004455c
obo:CHEBI_142468c

Hypofunction of 17β-Estradiol metabolic processc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005061
Super-classes obo:TXPO_0001375c
Sub-classes obo:TXPO_0004492c

1-hydroxyanthraquinonec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005062
Super-classes obo:CHEBI_28877c
obo:TXPO_0004455c

liver cancer dependent molecule (canonical)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005063
Super-classes obo:TXPO_0000837c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
Sub-classes obo:TXPO_0004817c
obo:TXPO_0004911c
obo:TXPO_0005016c
obo:TXPO_0004869c
obo:TXPO_0004913c
obo:TXPO_0004917c
obo:TXPO_0005003c
obo:TXPO_0004556c
obo:TXPO_0004510c
obo:TXPO_0004701c
obo:TXPO_0004726c
obo:TXPO_0004472c
obo:TXPO_0004547c
obo:TXPO_0005073c
obo:TXPO_0004915c
obo:TXPO_0005099c
obo:TXPO_0004826c
obo:TXPO_0004836c
obo:TXPO_0005002c
obo:TXPO_0005101c
obo:TXPO_0004482c
obo:TXPO_0005091c
obo:TXPO_0004527c
obo:TXPO_0005049c
obo:TXPO_0004861c
obo:TXPO_0004835c
obo:TXPO_0004862c
obo:TXPO_0004639c
obo:TXPO_0004863c
obo:TXPO_0004632c
obo:TXPO_0004872c
obo:TXPO_0004401c
obo:TXPO_0004912c
obo:TXPO_0004864c
obo:TXPO_0004873c
obo:TXPO_0004725c
obo:TXPO_0004866c
obo:TXPO_0004914c
obo:TXPO_0005047c
obo:TXPO_0004766c
obo:TXPO_0004601c
obo:TXPO_0004622c
obo:TXPO_0004916c
obo:TXPO_0004660c
obo:TXPO_0004727c
obo:TXPO_0004511c
obo:TXPO_0004910c
obo:TXPO_0004827c
obo:TXPO_0004638c
obo:TXPO_0004408c
obo:TXPO_0004918c
obo:TXPO_0004865c
obo:TXPO_0004631c
obo:TXPO_0004509c
obo:TXPO_0004433c
obo:TXPO_0004602c
obo:TXPO_0004967c
obo:TXPO_0004658c
obo:TXPO_0004665c

AGGF1 signal transduction pathwayc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005064
Super-classes obo:TXPO_0000609c

AGGF1 signal (primitive)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005065
Super-classes obo:GO_0023052c
Restrictions obo:TXPO_0002524op some obo:TXPO_0005064c
obo:RO_0000057op some obo:TXPO_1000502c
Sub-classes obo:TXPO_0004414c

AMPK(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005066
Super-classes obo:TXPO_0004293c
obo:TXPO_0003221c
Restrictions obo:TXPO_0002260op some obo:TXPO_0003221c

ATF4(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005067
Super-classes obo:TXPO_1000012c
obo:TXPO_0004185c
Restrictions obo:RO_0000087op some obo:TXPO_0000330c
obo:TXPO_0002260op some obo:IMR_0000825c
obo:TXPO_0000819op some obo:OGG_3000000468c
Sub-classes obo:TXPO_0004430c

BECN1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005068
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004930c

CADM1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005069
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004842c

liver cancer dependent molecule (rat)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005070
Super-classes obo:TXPO_0000837c
Restrictions obo:TXPO_0003360op some obo:NCBITaxon_10114c
Sub-classes obo:TXPO_0005007c
obo:TXPO_0004568c
obo:TXPO_0004842c
obo:TXPO_0004700c
obo:TXPO_0004774c
obo:TXPO_0004687c
obo:TXPO_0004533c
obo:TXPO_0004843c
obo:TXPO_0004571c
obo:TXPO_0004583c
obo:TXPO_0004606c
obo:TXPO_0004523c

CAR (mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005071
Super-classes obo:TXPO_0005072c
obo:TXPO_0003862c
Sub-classes obo:TXPO_0004450c

liver cancer dependent molecule (mouse in vitro)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005072
Super-classes obo:TXPO_0000837c
Restrictions obo:TXPO_0000756op some ncicp:C15958c
obo:TXPO_0003360op some obo:NCBITaxon_10090c
Sub-classes obo:TXPO_0004895c
obo:TXPO_0005071c
obo:TXPO_0004670c
obo:TXPO_0004699c
obo:TXPO_0005126c
obo:TXPO_0004893c
obo:TXPO_0004896c
obo:TXPO_0004770c
obo:TXPO_0004804c

CDH1 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005073
Super-classes obo:TXPO_0005063c
obo:TXPO_0005074c
Sub-classes obo:TXPO_0004872c

CDH1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005074
Super-classes obo:IMR_0000168c
Sub-classes obo:TXPO_0005073c

CDT1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005075
Super-classes obo:TXPO_0004467c
obo:TXPO_0004185c
Sub-classes obo:TXPO_0004469c

CYP2A13 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005076
Super-classes obo:TXPO_0001553c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001553c
Sub-classes obo:TXPO_0004911c

CYP2A6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005077
Super-classes obo:TXPO_0001553c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001548c
Sub-classes obo:TXPO_0004912c

CYP3A7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005078
Super-classes obo:TXPO_0001554c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001551c
Sub-classes obo:TXPO_0004915c

EPB41L3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005079
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004843c

FOXO1 (canonical)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005080
Super-classes obo:TXPO_0000472c
obo:IMR_0002805c
Restrictions obo:RO_0000087op some obo:TXPO_0003947c
obo:TXPO_0002260op some obo:IMR_0002805c
Sub-classes obo:TXPO_0004560c

FZD1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005081
Super-classes obo:TXPO_0004562c
Sub-classes obo:TXPO_0004861c

FZD2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005082
Super-classes obo:TXPO_0004562c
Sub-classes obo:TXPO_0004862c

FZD5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005083
Super-classes obo:TXPO_0004562c
Sub-classes obo:TXPO_0004863c

FZD6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005084
Super-classes obo:TXPO_0004562c
Sub-classes obo:TXPO_0004864c

FZD7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005085
Super-classes obo:TXPO_0004562c
Sub-classes obo:TXPO_0004865c

FZD9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005086
Super-classes obo:TXPO_0004562c
Sub-classes obo:TXPO_0004866c

GJA1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005087
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004953c

GJB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005088
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004950c

HHIP (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005089
Super-classes obo:TXPO_0004608c
obo:TXPO_0004185c
Sub-classes obo:TXPO_0004610c

HIF1A(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005090
Super-classes obo:TXPO_0004293c
obo:TXPO_0004613c
Sub-classes obo:TXPO_0004614c

HNF4A (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005091
Super-classes obo:TXPO_0005063c
obo:TXPO_0004621c
Sub-classes obo:TXPO_0004622c

HOTAIR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005092
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004509c

MST1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005093
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004638c

STK3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005094
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004639c

IGFBP3 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005095
Super-classes obo:TXPO_0004185c
obo:TXPO_0004645c
Sub-classes obo:TXPO_0004647c

KDR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005096
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005047c

KIAA0101 tv2 (predicted)(human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005097
Super-classes obo:TXPO_0004185c
obo:TXPO_0004193c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000009768c

MET (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005098
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004602c

MSH2 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005099
Super-classes obo:TXPO_0005063c
obo:TXPO_0005100c
Sub-classes obo:TXPO_0004510c

MSH2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005100
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005099c

MSH6 (canonical) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005101
Super-classes obo:TXPO_0005102c
obo:TXPO_0005063c
Sub-classes obo:TXPO_0004511c

MSH6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005102
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005101c

MTAP (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005103
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0005006c
obo:TXPO_0005007c

NDUFA12 (human) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005104
Super-classes obo:TXPO_0004707c
Sub-classes obo:TXPO_0005105c

NDUFA12 - inactive form (human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005105
Super-classes obo:TXPO_0003603c
obo:TXPO_0005104c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

NDUFA12 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005106
Super-classes obo:TXPO_0004706c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004375c
obo:RO_0002234op some obo:TXPO_0005105c
obo:TXPO_0000774op only obo:TXPO_0001986c

NDUFB6 (human) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005107
Super-classes obo:TXPO_0004709c
Sub-classes obo:TXPO_0005108c

NDUFB6 - inactive form (human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005108
Super-classes obo:TXPO_0003603c
obo:TXPO_0005107c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

NDUFB6 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005109
Super-classes obo:TXPO_0004708c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002234op some obo:TXPO_0005108c
obo:TXPO_0000069op some obo:TXPO_0004375c

NDUFS2 (human) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005110
Super-classes obo:TXPO_0004711c
Sub-classes obo:TXPO_0005111c

NDUFS2 - inactive form (human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005111
Super-classes obo:TXPO_0005110c
obo:TXPO_0003603c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

NDUFS2 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005112
Super-classes obo:TXPO_0001987c
obo:TXPO_0004710c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004375c
obo:RO_0002234op some obo:TXPO_0005111c
obo:TXPO_0000774op only obo:TXPO_0001986c

NDUFV1 (human) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005113
Super-classes obo:TXPO_0004713c
Sub-classes obo:TXPO_0005114c

NDUFV1 - inactive form (human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005114
Super-classes obo:TXPO_0003603c
obo:TXPO_0005113c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

NDUFV1 inactivation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005115
Super-classes obo:TXPO_0004712c
obo:TXPO_0001987c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001986c
obo:TXPO_0000069op some obo:TXPO_0004375c
obo:RO_0002234op some obo:TXPO_0005114c

NDUFV3 (human) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005116
Super-classes obo:TXPO_0004715c
Sub-classes obo:TXPO_0005117c

NDUFV3 - inactive form (human)[mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005117
Super-classes obo:TXPO_0003603c
obo:TXPO_0005116c
Restrictions obo:RO_0000086op some obo:PATO_0002355c

NDUFV3 inactovation [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005118
Super-classes obo:TXPO_0001987c
obo:TXPO_0004714c
Restrictions obo:TXPO_0000069op some obo:TXPO_0004375c
obo:TXPO_0000774op only obo:TXPO_0001986c
obo:RO_0002234op some obo:TXPO_0005117c

NOS2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005119
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004885c

NRF2(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005120
Super-classes obo:TXPO_0002527c
obo:TXPO_0004293c
Sub-classes obo:TXPO_0004721c

ORC1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005121
Super-classes obo:TXPO_0004185c
obo:TXPO_0004730c
Sub-classes obo:TXPO_0004732c

PCK1 (human) [Hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005122
Super-classes obo:TXPO_0004185c
obo:TXPO_1000524c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:TXPO_0000819op some obo:OGG_3000005105c
Sub-classes obo:TXPO_0004739c

PCK1 - inactive form (predicted)(human) [mitochondrial damage]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005123
Super-classes obo:TXPO_0003603c
obo:TXPO_0004176c
Restrictions obo:RO_0000086op some obo:TXPO_0000657c
obo:RO_0000086op some obo:PATO_0002355c
obo:TXPO_0000819op some obo:OGG_3000005105c

PHB (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005124
Super-classes obo:TXPO_0004748c
obo:TXPO_0004185c
Sub-classes obo:TXPO_0004750c

PPARA(canonical) [mitochondrial disorder]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005125
Super-classes obo:TXPO_0004293c
obo:TXPO_0000159c

PPARA(mouse) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005126
Super-classes obo:TXPO_0005072c
obo:TXPO_0000159c
Sub-classes obo:TXPO_0004770c

PPARGC1A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005127
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004769c

PROCR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005128
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084696c
Sub-classes obo:TXPO_0004533c

PROM1 - activation state (human)[hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005129
Super-classes obo:TXPO_0004780c
obo:TXPO_0004185c

PTK2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005130
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004547c

SFRP1 (human) [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005131
Super-classes obo:TXPO_0004185c
obo:TXPO_0004799c
Sub-classes obo:TXPO_0004801c

SNAI1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005132
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004812c

TERT (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005133
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004967c

TFAM (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005134
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004822c

TGFA (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005135
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004826c

USP7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005136
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004852c

YAP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005137
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004869c

bis(2-ethylhexyl) phthalate [hepatocarcinogenesis]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005138
Super-classes obo:TXPO_0004455c
obo:CHEBI_17747c

release of inflammatory DAMPsc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005139
Super-classes obo:TXPO_0002588c
Restrictions obo:BFO_0000066op some obo:GO_0005739c
Sub-classes obo:TXPO_0005031c

Less-DILI-Concernc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005140
Description

From Drug Induced Liver Injury Rank (DILIrank) Dataset. DILIrank consists of 1,036 FDA-approved drugs that are divided into four classes according to their potential for causing drug-induced liver injury (DILI).
Super-classes obo:TXPO_0004322c

changing quality of tumorc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005141
Super-classes obo:TXPO_0000415c
Restrictions obo:TXPO_0000531op some obo:PATO_0002011c
Sub-classes obo:TXPO_0005040c

No-DILI-Concernc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005142
Description

From Drug Induced Liver Injury Rank (DILIrank) Dataset. DILIrank consists of 1,036 FDA-approved drugs that are divided into four classes according to their potential for causing drug-induced liver injury (DILI).
Super-classes obo:TXPO_0004322c

central nervous system sphingomyelin homeostasis imbalance [Niemann Pick Disease Type A]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005143
Super-classes obo:TXPO_0003988c
Restrictions obo:BFO_0000051op some obo:TXPO_0005143c
obo:TXPO_0001733op some obo:TXPO_0002327c
obo:TXPO_0000069op some obo:TXPO_0001692c
obo:BFO_0000051op some obo:TXPO_0001482c
obo:TXPO_0000774op only obo:TXPO_0001468c

indomethacinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005144
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114206C17c)

rifampinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005145
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114224C17c)

dactinomycinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005146
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114242C17c)

methyldopac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005147
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114260C17c)

propylthiouracilc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005148
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114278C17c)

isoniazidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005149
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114296C17c)

niacinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005150
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114314C17c)

cyclosporinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005151
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114332C17c)

aminosalicylic acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005152
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114350C17c)

entecavirc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005153
Super-classes obo:CHEBI_50860c

nilotinib hydrochloride monohydratec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005154
Super-classes obo:CHEBI_50860c

ticrynafenc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005155
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114378C17c)

raltegravir potassiumc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005156
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114396C17c)

dronedarone hydrochloridec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005157
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114414C17c)

divalproex sodiumc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005158
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114432C17c)

aplavirocc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005159
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114450C17c)

pralnacasanc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005160
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114468C17c)

triacetyldiphenolisatinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005161
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114486C17c)

fiduxosinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005162
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114504C17c)

pafuramidinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005163
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114522C17c)

phenoxypropazinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005164
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114540C17c)

azacitidinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005165
Super-classes obo:CHEBI_50860c

cinchophenc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005166
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114563C17c)

exifonec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005167
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114581C17c)

fipexidec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005168
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114599C17c)

isocarboxazidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005169
Super-classes obo:CHEBI_50860c

moxisylytec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005170
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114622C17c)

nialamidec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005171
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114640C17c)

pentostatinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005172
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114658C17c)

suloctidilc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005173
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114676C17c)

fenclozic acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005174
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114694C17c)

tetrabamatec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005175
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114712C17c)

xenazoic acidc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005176
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114730C17c)

falnidamolc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005177
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114748C17c)

mepazinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005178
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114766C17c)

alaproclatec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005179
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114784C17c)

gemtuzumab ozogamicinc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005180
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114803C17c)

asparaginasec # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005181
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114822C17c)

interferon alfa-2bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005182
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114841C17c)

interferon beta-1ac # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005183
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114860C17c)

interferon alfacon-1c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005184
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114879C17c)

infliximabc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005185
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114898C17c)

peginterferon alfa-2bc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005186
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114917C17c)

natalizumabc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005187
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114936C17c)

sitaxsentanc # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005188
Super-classes obo:CHEBI_50860c
Restrictions obo:TXPO_0001862op some (obo:TXPO_0004321c and ub744bL114955C17c)

phospholipid biosynthetic process [Phospholipidosis(latent)]c # Classes

URI http://purl.obolibrary.org/obo/TXPO_0005189
Super-classes obo:TXPO_0001716c
obo:GO_0008654c
Restrictions obo:TXPO_0000774op only obo:TXPO_0001964c
obo:TXPO_0000069op some obo:TXPO_0002293c
obo:BFO_0000066op some obo:UBERON_0002107c

ABCG8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000000
Super-classes obo:TXPO_0002694c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064241c
Sub-classes obo:TXPO_0002616c

AFAP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000001
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000060312c

ANGPTL4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000002
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051129c
Sub-classes obo:TXPO_0000581c
obo:TXPO_0002022c

AP1M2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000003
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010053c
Sub-classes obo:TXPO_0003738c
obo:TXPO_0001532c

AP1S1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000004
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001174c
Sub-classes obo:TXPO_0003324c

APAF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000005
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000317c
Sub-classes obo:TXPO_0003196c

APOE (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000006
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000348c
Sub-classes obo:TXPO_0003517c

APOLD1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000007
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000081575c

APR moleculec # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000008
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0000320c
Sub-classes obo:TXPO_0003048c

ASAH1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000009
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000043op some obo:GO_0005764c
obo:TXPO_0000819op some obo:OGG_3000000427c
Sub-classes obo:TXPO_0000529c

DBF4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000010
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010926c
Sub-classes obo:TXPO_0002942c

ATF3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000011
Super-classes obo:IMR_0000825c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000467c
Sub-classes obo:TXPO_0002166c

ATF4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000012
Super-classes obo:IMR_0000825c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000468c
Sub-classes obo:TXPO_0005067c
obo:TXPO_0001907c

ATF6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000013
Super-classes obo:IMR_0000825c
Restrictions obo:TXPO_0000819op some obo:OGG_3000022926c
Sub-classes obo:TXPO_0000879c
obo:TXPO_0004433c
obo:IMR_0000831c
obo:IMR_0000832c

ATP-binding cassette (ABC) transporter superfamilyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000014
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000006c
obo:TXPO_0001506c

Abc1b1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000015
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004022c

Abhd1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000016
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084696c

Acaa1a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000017
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003247c
obo:TXPO_0001226c
obo:TXPO_0001074c
obo:TXPO_0003246c

Acbd6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000018
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084320c

Acer2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000019
Super-classes obo:TXPO_0001148c
Restrictions obo:TXPO_0000819op some obo:OGG_3000340485c

Acer3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000020
Super-classes obo:TXPO_0001148c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055331c

Acot12 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000021
Super-classes obo:TXPO_0001146c
Restrictions obo:TXPO_0000819op some obo:OGG_3000134526c
Sub-classes obo:TXPO_0002016c
obo:TXPO_0001067c
obo:TXPO_0000649c

Acot2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000022
Super-classes obo:TXPO_0001146c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010965c
Sub-classes obo:TXPO_0001058c

Acot3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000023
Super-classes obo:TXPO_0001146c
Sub-classes obo:TXPO_0001057c

Acot4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000024
Super-classes obo:TXPO_0001146c
Restrictions obo:TXPO_0000819op some obo:OGG_3000122970c
Sub-classes obo:TXPO_0001046c

Acot7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000025
Super-classes obo:TXPO_0001146c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011332c
Sub-classes obo:TXPO_0001068c

Acot8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000026
Super-classes obo:TXPO_0001146c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010005c
Sub-classes obo:TXPO_0000870c
obo:TXPO_0001069c

Acox1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000027
Super-classes obo:TXPO_0000033c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000051c
Sub-classes obo:TXPO_0003248c
obo:TXPO_0003249c
obo:TXPO_0001060c

Adam8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000028
Super-classes obo:IMR_0001865c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000101c

Aen (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000029
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064782c
Sub-classes obo:TXPO_0004044c

Ahr (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000030
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000196c
Sub-classes obo:TXPO_0000989c

Aig1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000031
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051390c

Aimp2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000032
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007965c

Akr7a3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000033
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000022977c
Sub-classes obo:TXPO_0001934c
obo:TXPO_0000654c

Alas1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000034
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000211c
Sub-classes obo:TXPO_0004003c
obo:TXPO_0000994c
obo:TXPO_0001774c
obo:TXPO_0003915c

ALDH1A1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000035
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000216c
Sub-classes obo:TXPO_0001001c
obo:TXPO_0001938c

Ankrd37 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000036
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000353322c
Sub-classes obo:TXPO_0001008c

Arfgap3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000037
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026286c

Ataxn10 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000038
Super-classes obo:CHEBI_25367c

Atr (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000039
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000545c

BAK1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000040
Super-classes obo:IMR_0000452c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000578c
Sub-classes obo:TXPO_0004355c
obo:TXPO_0003198c

BCL2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000041
Super-classes obo:IMR_0100706c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000596c
Sub-classes obo:TXPO_0000864c
obo:TXPO_0004917c

Bbs9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000043
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000027241c

Bcl3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000044
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000602c

Bhlha15 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000045
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000168620c
Sub-classes obo:TXPO_0001918c
obo:TXPO_0003519c
obo:TXPO_0000792c

Bhmt (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000046
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000635c
Sub-classes obo:TXPO_0001452c

Bip- stress sensor complex (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000047
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003309c
Sub-classes obo:TXPO_0002108c

Brd2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000048
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006046c

Btg2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000050
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007832c

C18ORF (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000051
Super-classes obo:CHEBI_25367c

C1orf162 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000052
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000128346c
Sub-classes obo:TXPO_0004051c

C6orf203 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000053
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051250c

C9orf72 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000054
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000203228c
Sub-classes obo:TXPO_0004171c

CA12 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000055
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000771c

CACNB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000056
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000782c

LRRC16B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000057
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000090668c
Sub-classes obo:TXPO_0004054c

CASP8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000058
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000841c
Sub-classes obo:TXPO_0003204c

CASP8AP2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000059
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009994c

CCDC126 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000060
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000090693c

CCNB2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000061
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009133c
Sub-classes obo:TXPO_0004056c

CD200 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000062
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004345c

CDK5R1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000063
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008851c

CENPE (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000064
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001062c
Sub-classes obo:TXPO_0004058c

CFLAR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000065
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008837c

CHAC1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000066
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079094c
Sub-classes obo:TXPO_0000807c

DDIT3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000067
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001649c
Sub-classes obo:TXPO_0002914c
obo:TXPO_0002167c
obo:TXPO_0000791c

CHORDC1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000068
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026973c

6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximec # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000069
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003910c

CLU (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000070
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001191c

CNOT6L (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000071
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000246175c

COL4A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000072
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001284c
Sub-classes obo:TXPO_0004042c

COX6B1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000073
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001340c

CRBPH (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000074
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003082c

CRELD2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000075
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079174c
Sub-classes obo:TXPO_0002169c
obo:TXPO_0000790c

CRP (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000076
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001401c
Sub-classes obo:TXPO_0003069c

CXCR3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000077
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002833c
Sub-classes obo:TXPO_0003778c
obo:TXPO_0004482c

CYP2B6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000078
Description

Orthologs of the human CYP2B6 genes can be found in other species including rats, mice, and dogs, which are termed Cyp2b1, Cyp2b10, and CYP2B11, respectively
Super-classes obo:TXPO_0001553c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001555c
Sub-classes obo:TXPO_0000979c
obo:TXPO_0001563c

CYP2C19 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000079
Super-classes obo:TXPO_0001553c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001557c
Sub-classes obo:TXPO_0001549c

CYP2D6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000080
Super-classes obo:TXPO_0001553c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001565c
Sub-classes obo:TXPO_0001568c

CYP2E1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000081
Super-classes obo:TXPO_0001553c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001571c
Sub-classes obo:TXPO_0003792c
obo:TXPO_0003170c
obo:TXPO_0004229c

CYP3A4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000082
Super-classes obo:TXPO_0001554c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001576c
Sub-classes obo:TXPO_0004913c
obo:TXPO_0001888c
obo:TXPO_0003171c
obo:TXPO_0003909c

CYP3A5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000083
Super-classes obo:TXPO_0001554c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001577c
Sub-classes obo:TXPO_0003605c
obo:TXPO_0004914c
obo:TXPO_0004063c

CYP4X1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000084
Super-classes obo:TXPO_0001555c
Restrictions obo:TXPO_0000819op some obo:OGG_3000260293c

Car2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000085
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000760c

CCL2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000086
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006347c
Sub-classes obo:TXPO_0003768c
obo:TXPO_0000778c
obo:TXPO_0003610c
obo:TXPO_0004291c

Cyclin D1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000088
Super-classes obo:IMR_0100614c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000595c
Sub-classes obo:TXPO_0004458c
obo:TXPO_0003006c
obo:TXPO_0004918c

Ccng1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000089
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000900c
Sub-classes obo:TXPO_0004057c

Cdc34 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000090
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000997c

Cdkn1a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000091
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001026c
Sub-classes obo:TXPO_0004059c

Cenpw (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000092
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000387103c
Sub-classes obo:TXPO_0004060c

Cnot11 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000093
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055571c

Ctnnb1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000094
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000986c
obo:TXPO_0004873c

Commd8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000095
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000054951c

Cpq (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000096
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010404c
Sub-classes obo:TXPO_0004062c

Cpt1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000097
Super-classes obo:CHEBI_25367c
Restrictions obo:RO_0000087op some obo:TXPO_0001967c
obo:TXPO_0000819op some obo:OGG_3000001374c
Sub-classes obo:TXPO_0001961c
obo:TXPO_0001050c
obo:TXPO_0004474c

Cpt2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000098
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001376c
Sub-classes obo:TXPO_0001064c

Cyp1A1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000100
Super-classes obo:TXPO_0001552c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001543c
Sub-classes obo:TXPO_0000991c
obo:TXPO_0004916c

Cyp2b1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000101
Super-classes obo:TXPO_0001553c
Sub-classes obo:TXPO_0001159c
obo:TXPO_0000990c
obo:TXPO_0001949c

Cyp2b10 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000102
Super-classes obo:TXPO_0001553c
Sub-classes obo:TXPO_0003907c

Cyp2c6v1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000103
Super-classes obo:TXPO_0001553c
Sub-classes obo:TXPO_0001173c

Cyp2d3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000104
Super-classes obo:TXPO_0001553c

Cyp2d4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000105
Super-classes obo:TXPO_0001553c

Cyp3a11 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000106
Super-classes obo:TXPO_0001554c
Sub-classes obo:TXPO_0003389c
obo:TXPO_0003908c

Cyp4a1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000107
Super-classes obo:TXPO_0001555c
Sub-classes obo:TXPO_0001081c

Cyp4a3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000108
Super-classes obo:TXPO_0001555c
Sub-classes obo:TXPO_0001053c

Cyp4f4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000109
Super-classes obo:TXPO_0001555c

DDIT4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000110
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000054541c

DDRGK1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000111
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000065992c

DDX25 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000112
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029118c

DGAT2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000113
Super-classes obo:TXPO_0001417c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084649c

DNAJB9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000114
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004189c
Sub-classes obo:TXPO_0000087c
obo:TXPO_0000783c
obo:TXPO_0002165c

DNAJC3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000115
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005611c
Sub-classes obo:TXPO_0003052c

DPH6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000116
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000089978c

Ddit4l (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000118
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000115265c

Ddx21 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000119
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009188c

Ddx6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000120
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001656c

Dnajc7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000121
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007266c

EIF4BP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000123
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000319118c

ELAVL4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000124
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001996c

ELOVL6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000125
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079071c
Sub-classes obo:TXPO_0003325c
obo:TXPO_0001252c
obo:TXPO_0001047c

ERO1LB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000126
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000056605c
Sub-classes obo:TXPO_0000805c
obo:TXPO_0003277c

DNAJC10 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000127
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000054431c
Sub-classes obo:TXPO_0002776c

ET-1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000128
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001906c
Sub-classes obo:TXPO_0003767c

Ech1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000129
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001891c

Ehhadh (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000131
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001962c
Sub-classes obo:TXPO_0001061c
obo:TXPO_0003250c

Eif2s1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000132
Super-classes obo:IMR_0010016c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001965c
Sub-classes obo:TXPO_0000640c

Eif4a1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000133
Super-classes obo:IMR_0010016c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001973c
Sub-classes obo:TXPO_0004030c

Eps8l2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000134
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064787c

Ero1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000135
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0002497c

Etnk2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000136
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055224c
Sub-classes obo:TXPO_0001171c

FABP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000137
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002168c
Sub-classes obo:TXPO_0003337c

FAF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000138
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011124c

FAS (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000139
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000355c
Sub-classes obo:TXPO_0004017c
obo:TXPO_0003200c

FASLG (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000140
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000356c
Sub-classes obo:TXPO_0000867c

FGF14 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000141
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002259c

FGF18 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000142
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008817c
Sub-classes obo:TXPO_0001140c

FGF19 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000143
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009965c
Sub-classes obo:TXPO_0003148c

FGF2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000144
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002247c
Sub-classes obo:TXPO_0002024c
obo:TXPO_0004556c

FGF21 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000145
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026291c
Sub-classes obo:TXPO_0000796c
obo:TXPO_0003274c
obo:TXPO_0004552c
obo:TXPO_0001884c

FHAD1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000146
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000114827c

FHIT (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000147
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002272c

FLCN (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000148
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000201163c
Sub-classes obo:TXPO_0004019c
obo:TXPO_0004024c

FN1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000149
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002335c

FNDC4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000150
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064838c
Sub-classes obo:TXPO_0003320c

Faah (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000152
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002166c
Sub-classes obo:TXPO_0001175c

Fabp5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000153
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002171c
Sub-classes obo:TXPO_0003347c

Fat1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000154
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002195c

Fnta (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000156
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002339c

G2e3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000157
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055632c

G6PD (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000158
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002539c
Sub-classes obo:TXPO_0001917c
obo:TXPO_0000135c

GABARAPL3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000159
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023766c

GADD45B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000160
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004616c
Sub-classes obo:TXPO_0000975c

GAS1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000161
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002619c

GCC2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000162
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009648c

GCLC [canonical] (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000163
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002729c
Sub-classes obo:TXPO_0000193c
obo:TXPO_0002453c
obo:TXPO_0001943c

GDF15 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000164
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009518c
Sub-classes obo:TXPO_0004571c
obo:TXPO_0004222c
obo:TXPO_0003613c
obo:TXPO_0004037c
obo:TXPO_0000518c

GDPD1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000165
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000284161c
Sub-classes obo:TXPO_0003323c

GFPT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000166
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002673c
Sub-classes obo:TXPO_0000806c

GLIPR1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000167
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011010c

GNE (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000168
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010020c

GPR39 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000169
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002863c

GRM8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000170
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002918c

HSP90B1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000171
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007184c
Sub-classes obo:TXPO_0000802c
obo:TXPO_0001960c
obo:TXPO_0002410c

GSK2606414c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000172
Super-classes obo:CHEBI_50860c
Sub-classes obo:TXPO_0003029c

GTSE1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000173
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051512c

Gadd45a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000174
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001647c
Sub-classes obo:TXPO_0001945c
obo:TXPO_0001158c
obo:TXPO_0000137c

Glutathione peroxidase (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000177
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003165c

Gpx2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000178
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002877c
Sub-classes obo:TXPO_0001952c

GSTA3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000179
Super-classes obo:TXPO_0002089c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002940c
Sub-classes obo:TXPO_0000229c
obo:TXPO_0001940c
obo:TXPO_0000996c

GSTM3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000180
Super-classes obo:TXPO_0002089c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002947c
Sub-classes obo:TXPO_0001954c
obo:TXPO_0002291c
obo:TXPO_0000228c

H3f3b (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000181
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003021c

HCK (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000182
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003055c

HDGFRP3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000183
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000050810c
Sub-classes obo:TXPO_0004033c

HERPUD1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000184
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009709c
Sub-classes obo:TXPO_0000810c

HIF3A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000185
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064344c

HLADPB2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000186
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003116c

HMGA1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000187
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003159c
Sub-classes obo:TXPO_0003762c

HMGCS1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000188
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003157c

HMGCS2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000189
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003158c
Sub-classes obo:TXPO_0004052c
obo:TXPO_0004050c

HSPA13 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000190
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006782c

HYOU1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000191
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010525c
Sub-classes obo:TXPO_0002164c
obo:TXPO_0002921c
obo:TXPO_0000800c

Hacl1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000192
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026061c

Hadhb (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000193
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003032c
Sub-classes obo:TXPO_0001070c

Hist1h2bcl1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000194
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008339c
Sub-classes obo:TXPO_0001919c
obo:TXPO_0004027c

Hist2h2aa3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000195
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008337c
Sub-classes obo:TXPO_0004071c

Hmox1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000196
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003162c
Sub-classes obo:TXPO_0004070c
obo:TXPO_0001329c
obo:TXPO_0003558c
obo:TXPO_0000645c
obo:TXPO_0000768c

Hnrnpab (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000197
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003182c

Hsdl2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000198
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084263c
Sub-classes obo:TXPO_0001048c

Htatip2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000199
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010553c

IL-1b (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000200
Super-classes obo:IMR_0000007c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003553c
Sub-classes obo:TXPO_0003828c
obo:TXPO_0004658c
obo:TXPO_0003191c
obo:TXPO_0004648c
obo:TXPO_0001875c

IL2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000201
Super-classes obo:IMR_0000007c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003558c
Sub-classes obo:TXPO_0002288c

IL2RB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000202
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003560c
Sub-classes obo:TXPO_0001143c

INHBE (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000203
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000083729c
Sub-classes obo:TXPO_0004073c

INSC (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000204
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000387755c

INTS6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000205
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000026512c

ITGB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000206
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003688c
Sub-classes obo:TXPO_0004075c

Ier3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000207
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008870c

IGFBP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000208
Super-classes obo:IMR_0002688c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003484c
Sub-classes obo:TXPO_0000776c

Ing4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000209
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051147c

Insig1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000210
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003638c

Insig2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000211
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051141c

Irf1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000212
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003659c
Sub-classes obo:TXPO_0004031c

Isyna1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000213
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051477c
Sub-classes obo:TXPO_0004074c

JMJD6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000214
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023210c
Sub-classes obo:TXPO_0004076c

JMY (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000215
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000133746c

MAPK8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000216
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0001813c
obo:TXPO_0004230c
obo:TXPO_0002298c

KIFC1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000217
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003833c

Kdelr2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000218
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011014c

Klf6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000219
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001316c

L3hypdh (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000220
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000112849c

LEAP2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000221
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000116842c
Sub-classes obo:TXPO_0003760c

LEMD1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000222
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000093273c

LGALS1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000223
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003956c

LINC00342 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000224
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000150759c

LMBR1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000225
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064327c

NR5A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000227
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002494c
Sub-classes obo:TXPO_0003125c

LSS (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000228
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004047c
Sub-classes obo:TXPO_0003330c

Lamtor5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000229
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010542c

Lmnb1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000230
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004001c
Sub-classes obo:TXPO_0001003c

Lpgat1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000231
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009926c
Sub-classes obo:TXPO_0001176c

MAB21L2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000232
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010586c

MANF (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000233
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007873c
Sub-classes obo:TXPO_0000798c

MAP2K6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000234
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005608c
Sub-classes obo:TXPO_0004013c

MAP3K13 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000235
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009175c

MED23 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000236
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009439c

MMP2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000238
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004313c
Sub-classes obo:TXPO_0003777c
obo:TXPO_0005002c

MMP9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000239
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004318c
Sub-classes obo:TXPO_0005003c
obo:TXPO_0003773c

M6PR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000240
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010857c
Sub-classes obo:TXPO_0001806c

MS4A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000241
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002206c

MUC3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000242
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3100133790c

MYCN (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000243
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004613c

Me1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000244
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004199c
Sub-classes obo:TXPO_0001936c

Mgll (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000245
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011343c
Sub-classes obo:TXPO_0001051c

Mybl2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000246
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004605c
Sub-classes obo:TXPO_0004078c

NAP1L1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000248
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004673c

NBAS (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000249
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051594c

NEFL (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000250
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004747c

NFKB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000251
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004790c
Sub-classes obo:TXPO_0002294c

NLRP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000252
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003039c

NME1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000253
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004830c

NUCB2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000254
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000004925c

NUDT4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000255
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011163c

Ndufaf4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000256
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029078c

NfkB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000258
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0002769c
obo:TXPO_0003167c
obo:TXPO_0003643c

Nfkbiz (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000259
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064332c

Nifib (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000260
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000650c

Nolc1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000261
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009221c

Nqo1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000262
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001728c

Nr1h2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000263
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007376c

Nrg1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000264
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003084c

Nudt11 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000265
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055190c
Sub-classes obo:TXPO_0004080c

Nudt5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000266
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011164c

Nudt7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000267
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000283927c

Nup153 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000268
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009972c

Nus1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000269
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000116150c

OATPs familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000270
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000272c

OCT family (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000271
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0002647c

Osgin1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000272
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029948c
Sub-classes obo:TXPO_0001935c
obo:TXPO_0000641c

PCDH9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000273
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005101c

PCK2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000274
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005106c

PDGF (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000275
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003752c

P4HB (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000276
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005034c
Sub-classes obo:TXPO_0002771c

PDLIM5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000277
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010611c

PEX11a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000278
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008800c
Sub-classes obo:TXPO_0001045c

PITX2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000279
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005308c

PRRT2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000280
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000112476c
Sub-classes obo:TXPO_0002411c

PLA2G15 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000281
Super-classes obo:TXPO_0000772c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023659c
Sub-classes obo:TXPO_0000775c

PLA2G16 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000282
Super-classes obo:IMR_0000283c
Restrictions obo:TXPO_0000819op some obo:OGG_3000011145c

PLA2G5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000283
Super-classes obo:IMR_0000283c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005322c
Sub-classes obo:TXPO_0002408c
obo:TXPO_0001142c

PLB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000284
Super-classes obo:TXPO_0001303c
Restrictions obo:TXPO_0000819op some obo:OGG_3000151056c
Sub-classes obo:TXPO_0001138c

PLD4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000285
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000122618c

PLIN2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000286
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000123c
Sub-classes obo:TXPO_0001084c
obo:TXPO_0001055c

PLK2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000287
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010769c

POU6F1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000288
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005463c

PPM1E (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000289
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000022843c

PRDM1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000290
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000639c

PTGER4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000292
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005734c

PTPN4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000293
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005775c
Sub-classes obo:TXPO_0001037c

Pank1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000294
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000053354c

Pcca (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000295
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005095c
Sub-classes obo:TXPO_0004005c

Pcsk7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000296
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009159c
Sub-classes obo:TXPO_0004083c

Pde2A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000297
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005138c

Pdk4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000298
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005166c
Sub-classes obo:TXPO_0001950c

Pdp2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000299
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000057546c

Pex19 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000300
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005824c

Pias3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000301
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010401c
Sub-classes obo:TXPO_0004038c

Pigz (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000302
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000080235c

Pik3c2g (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000303
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005288c
Sub-classes obo:TXPO_0003994c

Pir (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000304
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008544c

Plbd2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000305
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000196463c

Pln (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000306
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005350c

Pmm1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000307
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005372c

Pnrc2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000308
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055629c

Por (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000309
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005447c
Sub-classes obo:TXPO_0000995c

Prkcb (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000310
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005579c

Prmt5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000311
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010419c

Qprt (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000313
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023475c

RASGRP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000314
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010125c

RBL1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000315
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005933c

RBbp9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000316
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010741c

RECQL5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000317
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009400c

RFX3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000318
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005991c

RNF130 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000319
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055819c

RNF2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000320
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006045c

RT1-CE5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000321
Super-classes obo:CHEBI_25367c

Rad51b (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000322
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005890c
Sub-classes obo:TXPO_0004021c

Rasgef1b (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000323
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000153020c

Rbm8a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000324
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009939c

Rem2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000325
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000161253c

ritonavirc # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000327
Super-classes obo:CHEBI_50860c
Restrictions obo:RO_0000087op some obo:CHEBI_36044c
Sub-classes obo:TXPO_0003010c

Rnase1l2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000328
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004089c

Rock1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000329
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006093c

Rraga (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000330
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010670c

APCS (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000331
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000325c
Sub-classes obo:TXPO_0003086c

SCO1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000332
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006341c

SDF2L1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000333
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023753c

SEC24D (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000334
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009871c

SEC61B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000335
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010952c
Sub-classes obo:TXPO_0000811c

SERPINA3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000336
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000012c
Sub-classes obo:TXPO_0003339c

SESN1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000337
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000027244c
Sub-classes obo:TXPO_0004036c

SLC10A1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000338
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006554c
Sub-classes obo:TXPO_0000547c

SLC1A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000339
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006506c

SLC25A4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000340
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000291c

SLC29A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000341
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003177c

SLC2A3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000342
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006515c
Sub-classes obo:TXPO_0003335c

SLC35F5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000343
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000080255c

SLC44A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000344
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000057153c
Sub-classes obo:TXPO_0001136c

SMARCD3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000345
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0002020c

SMO (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000346
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006608c

SMPD1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000347
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006609c
Sub-classes obo:TXPO_0001464c

SMPDL3A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000348
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010924c
Sub-classes obo:TXPO_0003322c

SORBS1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000349
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010580c

SPTLC2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000350
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009517c

SRPK2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000351
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006733c

SRSF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000352
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006426c
Sub-classes obo:TXPO_0004041c

STARD7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000353
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000056910c
Sub-classes obo:TXPO_0002028c

STF-083010c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000354
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003028c

STK11 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000355
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006794c

STUB1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000356
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010273c

SYNGR2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000357
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009144c

PTPN6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000358
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005777c
Sub-classes obo:TXPO_0002723c

Skap2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000359
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008935c

Slc25a20 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000360
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000788c
Sub-classes obo:TXPO_0001066c

Slc5a6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000361
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008884c

Smn1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000362
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006606c

Srnx1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000364
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000998c

Srxn1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000365
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000140809c
Sub-classes obo:TXPO_0001928c

Ssbp1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000366
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006742c

Ssr3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000367
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006747c

Sub1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000368
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010923c
Sub-classes obo:TXPO_0004091c

TAGLN (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000369
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006876c
Sub-classes obo:TXPO_0003334c

TGF (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000370
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000999c

TGFbeta1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000371
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003893c
obo:TXPO_0003892c
obo:TXPO_0004827c
obo:TXPO_0003895c
obo:TXPO_0003751c

THBS1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000372
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007057c

TIMP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000373
Super-classes obo:TXPO_1000431c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007076c
Sub-classes obo:TXPO_0003062c

TNF-a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000374
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007124c
Sub-classes obo:TXPO_0004835c
obo:TXPO_0003194c
obo:TXPO_0004381c
obo:TXPO_0003201c
obo:TXPO_0000863c
obo:TXPO_0001901c
obo:TXPO_0003776c

TNFRSF9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000375
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003604c

TP53INP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000376
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000094241c

TRA2A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000377
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029896c

TRIB3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000378
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000057761c
Sub-classes obo:TXPO_0001953c
obo:TXPO_0000779c
obo:TXPO_0002168c

TSHZ2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000379
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000128553c

TWIST1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000380
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007291c
Sub-classes obo:TXPO_0004849c
obo:TXPO_0004093c

Taf9 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000381
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006880c

Tnfrsf12a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000383
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000051330c

Tnfrsf21 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000384
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000027242c

Tomm20 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000385
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009804c

Tor1aip2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000386
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000163590c

Tsc22d3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000387
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001831c

TUBB4A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000388
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010382c

Txnrd1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000389
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007296c
Sub-classes obo:TXPO_0000997c
obo:TXPO_0001930c

Txrnd1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000390
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000642c

Tyms (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000391
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007298c
Sub-classes obo:TXPO_0004094c

UBE2I (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000392
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007329c

UCP3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000393
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007352c
Sub-classes obo:TXPO_0002015c

UGCG (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000394
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007357c

UGT1a1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000395
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000054658c
Sub-classes obo:TXPO_0000953c

USF2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000396
Super-classes obo:TXPO_0001111c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007392c
Sub-classes obo:TXPO_0001103c

Ugt2b1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000397
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000992c

Ugt2b7 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000398
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007364c
Sub-classes obo:TXPO_0004039c

VNN3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000399
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055350c

Vangl2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000400
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000057216c

Vav2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000401
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007410c
Sub-classes obo:TXPO_0001000c

Vnn1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000403
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008876c

XBP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000405
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007494c
Sub-classes obo:TXPO_0001968c

ZNF385B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000406
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000151126c
Sub-classes obo:TXPO_0004199c
obo:TXPO_0004029c

ZNF667 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000407
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000063934c

Zc3h14 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000408
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079882c

Zfand2a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000409
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000090637c

caspase (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000414
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000502c

cebpd (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000415
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001052c
Sub-classes obo:TXPO_0000771c

chloroquinec # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000418
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0000500c

cxc family (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000419
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0003281c

eIF2a (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000421
Super-classes obo:IMR_0010016c
Restrictions obo:TXPO_0000819op some obo:OGG_3000083939c
Sub-classes obo:TXPO_0001275c

gentamicin (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000422
Super-classes obo:CHEBI_25367c

TIMP familyc # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000431
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_1000373c
obo:TXPO_0003784c

calreticulin (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000435
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0002897c

fibratec # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000442
Super-classes obo:CHEBI_50860c
Sub-classes obo:CHEBI_3750c
obo:TXPO_0000121c
obo:CHEBI_5001c

ACSM2A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000500
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000123876c
Sub-classes obo:TXPO_0004189c

ACSM2B (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000501
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000348158c
Sub-classes obo:TXPO_0004190c

AGGF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000502
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055109c
Sub-classes obo:TXPO_0004195c

ATAD2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000503
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029028c
Sub-classes obo:TXPO_0004170c

BCL2A1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000504
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000597c
Sub-classes obo:TXPO_0004165c

CDCA5 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000506
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000113130c
Sub-classes obo:TXPO_0004183c

CDK1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000507
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000000983c
Sub-classes obo:TXPO_0003611c

CLMN (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000508
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079789c
Sub-classes obo:TXPO_0004196c

CXCL6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000509
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006372c
Sub-classes obo:TXPO_0003607c

CXCL8 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000510
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004198c

CYP1A1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000511
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001543c
Sub-classes obo:TXPO_0004167c

CYP1A2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000512
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001544c
Sub-classes obo:TXPO_0004202c

DHFR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000513
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001719c
Sub-classes obo:TXPO_0003614c

DPYD (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000514
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000001806c
Sub-classes obo:TXPO_0004192c

FEN1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000515
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002237c
Sub-classes obo:TXPO_0004519c
obo:TXPO_0004172c

GFRA1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000516
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000002674c
Sub-classes obo:TXPO_0004169c

GPHN (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000517
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010243c
Sub-classes obo:TXPO_0004188c

HILPDA (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000518
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029923c
Sub-classes obo:TXPO_0004194c

HMMR (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000519
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000003161c
Sub-classes obo:TXPO_0003612c

KIAA0101 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000520
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000009768c
Sub-classes obo:TXPO_0004193c

NEAT1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000521
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000283131c
Sub-classes obo:TXPO_0004177c

ORC6 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000522
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000023594c
Sub-classes obo:TXPO_0004182c

PBLD (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000523
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000064081c
Sub-classes obo:TXPO_0003604c

PCK1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000524
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005105c
Sub-classes obo:TXPO_0004176c
obo:TXPO_0005122c

PIM3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000525
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000415116c
Sub-classes obo:TXPO_0004168c
obo:TXPO_0004756c

PMAIP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000526
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000005366c
Sub-classes obo:TXPO_0004200c
obo:TXPO_0004763c

PTPRD (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000527
Super-classes obo:CHEBI_25367c
Sub-classes obo:TXPO_0004186c

RAD51AP1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000528
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000010635c
Sub-classes obo:TXPO_0003608c

RHNO1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000529
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000083695c
Sub-classes obo:TXPO_0004181c

RPS29 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000530
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006235c
Sub-classes obo:TXPO_0004197c

SCAPER (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000531
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000049855c
Sub-classes obo:TXPO_0004187c

SEL1L (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000532
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006400c
Sub-classes obo:TXPO_0004175c

SKA2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000533
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000348235c
Sub-classes obo:TXPO_0004173c

SLC38A4 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000534
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055089c
Sub-classes obo:TXPO_0004164c

SLC3A1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000535
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000006519c
Sub-classes obo:TXPO_0004180c

SPTLC3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000536
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000055304c
Sub-classes obo:TXPO_0004191c
obo:TXPO_0004804c

SRPX2 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000537
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000027286c
Sub-classes obo:TXPO_0004178c

TMEM139 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000538
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000135932c
Sub-classes obo:TXPO_0004204c

TMEM150C (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000539
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000441027c
Sub-classes obo:TXPO_0004206c

TMPO (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000540
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000007112c
Sub-classes obo:TXPO_0004179c

TNFSF10 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000541
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000008743c
Sub-classes obo:TXPO_0003606c

TRIM55 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000542
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000084675c
Sub-classes obo:TXPO_0004166c

TSKU (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000543
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000025987c
Sub-classes obo:TXPO_0004174c

TTC39A (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000544
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000022996c
Sub-classes obo:TXPO_0004205c

UBE2T (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000545
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029089c
Sub-classes obo:TXPO_0004184c

UGT2A3 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000546
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000079799c
Sub-classes obo:TXPO_0004201c

UHRF1 (mol)c # Classes

URI http://purl.obolibrary.org/obo/TXPO_1000547
Super-classes obo:CHEBI_25367c
Restrictions obo:TXPO_0000819op some obo:OGG_3000029128c
Sub-classes obo:TXPO_0004203c

nosec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000004
Description

the structure of the nose varies across vertebrates. In tetrapods the nose is part of the respiratory system.[PMID:25312359]
Super-classes obo:UBERON_0002268c
Restrictions obo:BFO_0000050op some obo:UBERON_0001004c

sense organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000020
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0001032c
Sub-classes obo:UBERON_0002268c
obo:UBERON_0000970c
obo:UBERON_0001723c
obo:UBERON_0001690c

tube (anatomical)c # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000025
Description

not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts)
Super-classes obo:UBERON_0004111c
Sub-classes obo:UBERON_0000058c
obo:TXPO_0000491c
obo:UBERON_0001981c
obo:UBERON_0002394c
obo:UBERON_0000056c

ureterc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000056
Description

in humans, consists of adventitial, muscular and mucoa layers
Super-classes obo:UBERON_0000025c
Restrictions obo:BFO_0000050op some obo:UBERON_0001008c
core:channel_forop some obo:UBERON_0001088c

ductc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000058
Super-classes obo:UBERON_0000025c
Sub-classes obo:UBERON_0003928c

large intestinec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000059
Super-classes obo:UBERON_0000160c

anatomical structurec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000061
Super-classes obo:UBERON_0001062c
Sub-classes obo:UBERON_0000062c
obo:UBERON_0011216c
obo:UBERON_0000467c
obo:UBERON_0000064c
obo:UBERON_0004111c
obo:UBERON_0010000c

organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000062
Super-classes obo:UBERON_0000061c
Restrictions obo:BFO_0000050op some obo:UBERON_0000467c
Sub-classes obo:UBERON_0001630c
obo:UBERON_0000948c
obo:UBERON_0000020c
obo:UBERON_0002097c
obo:UBERON_0000955c
obo:UBERON_0003133c
obo:UBERON_0002113c
obo:UBERON_0002240c
obo:UBERON_0000171c
obo:UBERON_0002530c
obo:UBERON_0001264c
obo:UBERON_0013765c
obo:UBERON_0002106c

organ partc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000064
Super-classes obo:UBERON_0000061c
Restrictions obo:BFO_0000050op some obo:UBERON_0000062c
Sub-classes obo:UBERON_0000966c

intestinec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000160
Super-classes obo:UBERON_0013765c
Restrictions obo:BFO_0000050op some obo:UBERON_0001007c
Sub-classes obo:UBERON_0002108c
obo:UBERON_0000059c
obo:UBERON_0001155c
obo:UBERON_0001052c

pair of lungsc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000170
Super-classes obo:UBERON_0034925c
Restrictions obo:RO_0002351op some obo:UBERON_0002167c
obo:RO_0002351op some obo:UBERON_0002168c

respiration organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000171
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0001004c
Sub-classes obo:UBERON_0002048c

bloodc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000178
Super-classes obo:UBERON_0000179c
Restrictions obo:BFO_0000051op some obo:UBERON_0001969c
obo:BFO_0000050op some obo:UBERON_0002390c
obo:BFO_0000050op some obo:UBERON_0004535c
Sub-classes obo:UBERON_0013756c

haemolymphatic fluidc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000179
Super-classes obo:UBERON_0006314c
Restrictions obo:BFO_0000050op some obo:UBERON_0002193c
Sub-classes obo:UBERON_0001969c
obo:UBERON_0000178c

organism substancec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000463
Super-classes obo:BFO_0000027c
Sub-classes obo:UBERON_0006314c
obo:UBERON_0001088c
In range of core:channel_forop

anatomical spacec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000464
Super-classes obo:UBERON_0001062c
Sub-classes obo:UBERON_0001283c
obo:GO_0043233c
obo:UBERON_0013686c

anatomical systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000467
Super-classes obo:UBERON_0000061c
Restrictions obo:BFO_0000051op some obo:UBERON_0000062c
Sub-classes obo:UBERON_0001008c
obo:UBERON_0001016c
obo:UBERON_0002193c
obo:UBERON_0004122c
obo:UBERON_0007798c
obo:UBERON_0001009c
obo:UBERON_0002405c
obo:UBERON_0001007c
obo:UBERON_0000990c
obo:UBERON_0001032c
obo:UBERON_0002390c
obo:UBERON_0004535c
obo:UBERON_0002204c
obo:UBERON_0001004c
obo:UBERON_0002416c
obo:UBERON_0000949c
obo:UBERON_0002330c

tissuec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000479
Super-classes obo:UBERON_0010000c
obo:TXPO_0000065c
Sub-classes obo:UBERON_0000483c
obo:UBERON_0001134c
obo:UBERON_0002385c
obo:UBERON_0002384c
obo:UBERON_0002371c
obo:UBERON_0001013c

epitheliumc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000483
Super-classes obo:UBERON_0000479c

stomachc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000945
Description

UBERON ontology restricts this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa
Super-classes obo:UBERON_0013765c
Restrictions obo:BFO_0000050op some obo:UBERON_0001007c

heartc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000948
Description

Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" http://dx.doi.org/10.1101/gad.1485706
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0004535c

endocrine systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000949
Super-classes obo:UBERON_0000467c
Restrictions obo:RO_0002473op some obo:UBERON_0002368c

brainc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000955
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0001017c

retinac # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000966
Super-classes obo:UBERON_0000064c

eyec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000970
Description

Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva,
Super-classes obo:UBERON_0000020c

reproductive systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0000990
Super-classes obo:UBERON_0000467c

respiratory systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001004
Super-classes obo:UBERON_0000467c

digestive systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001007
Super-classes obo:UBERON_0000467c

renal systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001008
Description

In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels
Super-classes obo:UBERON_0000467c
obo:UBERON_0011216c

circulatory systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001009
Super-classes obo:UBERON_0000467c

adipose tissuec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001013
Super-classes obo:UBERON_0000479c

nervous systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001016
Super-classes obo:UBERON_0000467c

central nervous systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001017
Super-classes obo:UBERON_0011216c
Restrictions obo:BFO_0000050op some obo:UBERON_0001016c

sensory systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001032
Super-classes obo:UBERON_0000467c
Restrictions obo:BFO_0000051op some ()

esophagusc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001043
Super-classes obo:UBERON_0013765c
Restrictions obo:BFO_0000050op some obo:UBERON_0001007c

rectumc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001052
Super-classes obo:UBERON_0000160c
Restrictions obo:BFO_0000050op some obo:UBERON_0000059c

anatomical entityc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001062
Super-classes obo:BFO_0000030c
Sub-classes obo:UBERON_0034925c
obo:UBERON_0000061c
obo:GO_0005575c
obo:UBERON_0000464c
In range of obo:TXPO_0000043op

urinec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001088
Description

kidney excreta from some taxa (e.g. in aves) may not be liquid
Super-classes obo:UBERON_0000463c

lobe of liverc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001113
Super-classes obo:BFO_0000024c
Restrictions obo:BFO_0000050op some obo:UBERON_0002107c
Sub-classes obo:UBERON_0001115c

left lobe of liverc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001115
Super-classes obo:UBERON_0001113c

skeletal muscle tissuec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001134
Super-classes obo:UBERON_0000479c

hepatic veinc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001143
Super-classes obo:UBERON_0015796c
Sub-classes obo:UBERON_0006841c

colonc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001155
Description

Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]
Super-classes obo:UBERON_0000160c
Restrictions obo:BFO_0000050op some obo:UBERON_0000059c

biliary treec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001173
Description

The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct exits liver and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP]
Super-classes obo:UBERON_0011216c
Restrictions obo:BFO_0000050op some obo:UBERON_0002294c

hepatic arteryc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001193
Super-classes obo:UBERON_0015796c
Restrictions obo:RO_0002178op some obo:UBERON_0002107c
Sub-classes obo:UBERON_0015480c
obo:UBERON_0015482c
obo:UBERON_0015481c

pancreasc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001264
Super-classes obo:UBERON_0000062c

hepatic sinusoidc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001281
Super-classes obo:UBERON_0015796c

bile canaliculusc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001283
Description

bile canaliculus
Super-classes obo:UBERON_0000464c
Restrictions obo:BFO_0000050op some obo:UBERON_0002394c
obo:BFO_0000050op some obo:UBERON_0001113c

skeletal systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001434
Super-classes obo:UBERON_0011216c
Restrictions obo:BFO_0000051op some obo:UBERON_0004288c
obo:BFO_0000050op some obo:UBERON_0002204c
obo:BFO_0000051op some obo:UBERON_0004770c

coronary arteryc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001621
Super-classes obo:UBERON_0003509c

muscle organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001630
Super-classes obo:UBERON_0000062c
Restrictions obo:RO_0002473op some obo:UBERON_0002385c
Sub-classes obo:UBERON_0014892c

arteryc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001637
Super-classes obo:UBERON_0003509c
Restrictions obo:BFO_0000050op some obo:UBERON_0004572c

veinc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001638
Super-classes obo:UBERON_0003920c

earc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001690
Super-classes obo:UBERON_0000020c

tonguec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001723
Super-classes obo:UBERON_0000020c

blood plasmac # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001969
Super-classes obo:UBERON_0000179c
Restrictions obo:BFO_0000050op some obo:UBERON_0000178c

bilec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001970
Description

In many species, bile is stored in the gallbladder and upon eating is discharged into the duodenum.
Super-classes obo:UBERON_0006314c

blood vesselc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0001981
Description

FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX
Super-classes obo:UBERON_0000025c
Restrictions core:channel_forop some obo:UBERON_0000178c
Sub-classes obo:UBERON_0003501c
obo:UBERON_0003920c
obo:UBERON_0015796c
obo:UBERON_0003909c
obo:UBERON_0003509c

lungc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002048
Description

Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]
Super-classes obo:UBERON_0000171c
Restrictions obo:BFO_0000050op some obo:UBERON_0001004c
Sub-classes obo:UBERON_0002167c
obo:UBERON_0002168c

skin of bodyc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002097
Super-classes obo:UBERON_0000062c

spleenc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002106
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0002390c

liverc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002107
Super-classes obo:UBERON_0013765c
Restrictions obo:BFO_0000067op some obo:GO_0005980c
obo:BFO_0000067op some obo:TXPO_0002552c
obo:BFO_0000050op some obo:UBERON_0002423c
obo:BFO_0000067op some obo:TXPO_0000173c
obo:BFO_0000067op some obo:GO_0002384c
obo:BFO_0000051op some ()
obo:BFO_0000051op some obo:UBERON_0001113c
obo:BFO_0000067op some obo:GO_0008152c
obo:BFO_0000067op some obo:GO_0005978c
obo:BFO_0000067op some obo:GO_0005977c
obo:BFO_0000050op some obo:UBERON_0002330c
obo:BFO_0000067op some obo:GO_0032782c
obo:BFO_0000050op some obo:UBERON_0001007c
obo:BFO_0000050op some obo:UBERON_0000949c

small intestinec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002108
Super-classes obo:UBERON_0000160c
Restrictions obo:BFO_0000050op some obo:UBERON_0000160c

gall bladderc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002110
Description

Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988)
Super-classes obo:UBERON_0013765c
Restrictions obo:BFO_0000050op some obo:UBERON_0002423c

kidneyc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002113
Super-classes obo:UBERON_0000062c

right lungc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002167
Description

https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern
Super-classes obo:UBERON_0002048c
Restrictions obo:BFO_0000050op some obo:UBERON_0000170c

left lungc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002168
Description

https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern
Super-classes obo:UBERON_0002048c
Restrictions obo:BFO_0000050op some obo:UBERON_0000170c

hemolymphoid systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002193
Super-classes obo:UBERON_0000467c

musculoskeletal systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002204
Super-classes obo:UBERON_0000467c
Restrictions obo:BFO_0000051op some obo:UBERON_0001434c

spinal cordc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002240
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0001017c

olfactory organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002268
Super-classes obo:UBERON_0000020c
Sub-classes obo:UBERON_0000004c

biliary systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002294
Super-classes obo:UBERON_0011216c
Restrictions obo:BFO_0000051op some obo:UBERON_0001173c
obo:BFO_0000050op some obo:UBERON_0002423c

exocrine systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002330
Super-classes obo:UBERON_0000467c
Restrictions obo:RO_0002473op some obo:UBERON_0002365c

exocrine glandc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002365
Super-classes obo:UBERON_0002530c
Restrictions obo:BFO_0000050op some obo:UBERON_0002330c

endocrine glandc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002368
Super-classes obo:UBERON_0002530c
Restrictions obo:BFO_0000050op some obo:UBERON_0000949c

bone marrowc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002371
Super-classes obo:UBERON_0000479c

connective tissuec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002384
Super-classes obo:UBERON_0000479c
Sub-classes obo:UBERON_0004755c

muscle tissuec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002385
Description

Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach.
Super-classes obo:UBERON_0000479c

hematopoietic systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002390
Description

In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes
Super-classes obo:UBERON_0000467c
Restrictions obo:BFO_0000050op some obo:UBERON_0002193c

bile ductc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002394
Super-classes obo:UBERON_0000025c
Restrictions obo:BFO_0000050op some obo:UBERON_0001007c
core:channel_forop some obo:UBERON_0001970c

immune systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002405
Super-classes obo:UBERON_0000467c

integumental systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002416
Super-classes obo:UBERON_0000467c

hepatobiliary systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002423
Super-classes obo:UBERON_0011216c
Restrictions obo:BFO_0000051op some obo:UBERON_0002294c
obo:BFO_0000051op some obo:UBERON_0002107c
obo:BFO_0000050op some obo:UBERON_0001007c

bone tissuec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002481
Super-classes obo:UBERON_0004755c

glandc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0002530
Super-classes obo:UBERON_0000062c
Sub-classes obo:UBERON_0002365c
obo:UBERON_0002368c

reproductive organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0003133
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0000990c
Sub-classes obo:UBERON_0003134c

female reproductive organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0003134
Super-classes obo:UBERON_0003133c

retina blood vesselc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0003501
Super-classes obo:UBERON_0001981c

arterial blood vesselc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0003509
Description

only in MA - supertype of artery, arteriole, aorta.
Super-classes obo:UBERON_0001981c
Restrictions obo:BFO_0000050op some obo:UBERON_0004572c
Sub-classes obo:UBERON_0001621c
obo:UBERON_0001637c

sinusoidc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0003909
Super-classes obo:UBERON_0001981c

venous blood vesselc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0003920
Description

Compare to: vein
Super-classes obo:UBERON_0001981c
Restrictions obo:BFO_0000050op some obo:UBERON_0004582c
Sub-classes obo:UBERON_0001638c

digestive system ductc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0003928
Super-classes obo:UBERON_0000058c
Restrictions obo:BFO_0000050op some obo:UBERON_0001007c

anatomical conduitc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004111
Super-classes obo:UBERON_0000061c
Restrictions obo:BFO_0000051op some obo:UBERON_0013686c
Sub-classes obo:UBERON_0000025c
In domain of core:channel_forop

genitourinary systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004122
Super-classes obo:UBERON_0000467c
Restrictions obo:BFO_0000051op some obo:UBERON_0001008c
obo:BFO_0000051op some obo:UBERON_0000990c

skeletonc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004288
Super-classes obo:UBERON_0034925c
Restrictions obo:BFO_0000050op some obo:UBERON_0001434c

cardiovascular systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004535
Super-classes obo:UBERON_0000467c
Restrictions obo:BFO_0000050op some obo:UBERON_0001009c
obo:BFO_0000051op some obo:UBERON_0001981c

systemic arterial systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004571
Super-classes obo:UBERON_0007798c
Restrictions obo:BFO_0000050op some obo:UBERON_0004572c

arterial systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004572
Super-classes obo:UBERON_0007798c
Restrictions obo:BFO_0000050op some obo:UBERON_0004535c
obo:RO_0002351op some obo:UBERON_0001637c

venous systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004582
Super-classes obo:UBERON_0007798c
Restrictions obo:RO_0002473op some obo:UBERON_0001638c

skeletal tissuec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004755
Description

Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
Super-classes obo:UBERON_0002384c
Sub-classes obo:UBERON_0002481c

articular systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0004770
Super-classes obo:UBERON_0034925c
Restrictions obo:BFO_0000050op some obo:UBERON_0001434c

bodily fluidc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0006314
Super-classes obo:UBERON_0000463c
Sub-classes obo:UBERON_0000179c
obo:UBERON_0001970c

central vein of liverc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0006841
Super-classes obo:UBERON_0001143c

vascular systemc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0007798
Super-classes obo:UBERON_0000467c
Restrictions obo:BFO_0000050op some obo:UBERON_0004535c
Sub-classes obo:UBERON_0004571c
obo:UBERON_0004582c
obo:UBERON_0004572c

multicellular anatomical structurec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0010000
Super-classes obo:UBERON_0000061c
Sub-classes obo:UBERON_0000479c

organ system subdivisionc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0011216
Super-classes obo:UBERON_0000061c
Restrictions obo:BFO_0000050op some obo:UBERON_0000467c
Sub-classes obo:UBERON_0001434c
obo:UBERON_0002294c
obo:UBERON_0001173c
obo:UBERON_0002423c
obo:UBERON_0001008c
obo:UBERON_0001017c

anatomical conduit spacec # Classes

URI http://purl.obolibrary.org/obo/UBERON_0013686
Super-classes obo:UBERON_0000464c

venous bloodc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0013756
Super-classes obo:UBERON_0000178c
Restrictions obo:BFO_0000050op some obo:UBERON_0001638c

digestive system elementc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0013765
Super-classes obo:UBERON_0000062c
Restrictions obo:BFO_0000050op some obo:UBERON_0001007c
Sub-classes obo:UBERON_0000945c
obo:UBERON_0001043c
obo:UBERON_0002107c
obo:UBERON_0000160c
obo:UBERON_0002110c

skeletal muscle organc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0014892
Super-classes obo:UBERON_0001630c
Restrictions obo:RO_0002473op some obo:UBERON_0001134c

hepatic artery properc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0015480
Super-classes obo:UBERON_0001193c

left hepatic arteryc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0015481
Super-classes obo:UBERON_0001193c

right hepatic arteryc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0015482
Super-classes obo:UBERON_0001193c

liver blood vesselc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0015796
Super-classes obo:UBERON_0001981c
Restrictions obo:BFO_0000050op some obo:UBERON_0002107c
Sub-classes obo:UBERON_0001281c
obo:UBERON_0001193c
obo:UBERON_0001143c

anatomical collectionc # Classes

URI http://purl.obolibrary.org/obo/UBERON_0034925
Super-classes obo:UBERON_0001062c
Restrictions obo:RO_0002351op some obo:UBERON_0000061c
Sub-classes obo:UBERON_0004288c
obo:UBERON_0004770c
obo:UBERON_0000170c

mitochondrial DNAc # Classes

URI http://www.ebi.ac.uk/efo/EFO_0008480
Super-classes obo:CHEBI_16991c

Object Properties ↑

part ofop # OPs

URI http://purl.obolibrary.org/obo/BFO_0000050
Inverse properties obo:BFO_0000051op

has partop # OPs

URI http://purl.obolibrary.org/obo/BFO_0000051
Super-properties owl:topObjectProperty

occurs inop # OPs

URI http://purl.obolibrary.org/obo/BFO_0000066
Is Defined By http://purl.obolibrary.org/obo/bfo.owl
Description

Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
Inverse properties obo:BFO_0000067op
Domain(s) obo:BFO_0000003c
Range(s) obo:BFO_0000004c

contains processop # OPs

URI http://purl.obolibrary.org/obo/BFO_0000067

is gene of organismop # OPs

URI http://purl.obolibrary.org/obo/OGG_0000000016

inheres inop # OPs

URI http://purl.obolibrary.org/obo/RO_0000052
Inverse properties obo:RO_0000053op

bearer ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0000053
Range(s) obo:BFO_0000020c

participates inop # OPs

URI http://purl.obolibrary.org/obo/RO_0000056
Inverse properties obo:RO_0000057op
Domain(s) obo:BFO_0000002c
Range(s) obo:BFO_0000003c

has participantop # OPs

URI http://purl.obolibrary.org/obo/RO_0000057
Super-properties owl:topObjectProperty
Domain(s) obo:BFO_0000003c
Range(s) obo:BFO_0000002c

function ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0000079
Super-properties obo:RO_0000052op
Inverse properties obo:RO_0000085op
Domain(s) obo:BFO_0000034c

quality ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0000080
Super-properties obo:RO_0000052op
Inverse properties obo:RO_0000086op

role ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0000081
Super-properties obo:RO_0000052op
Inverse properties obo:RO_0000087op

has functionop # OPs

URI http://purl.obolibrary.org/obo/RO_0000085
Super-properties obo:RO_0000053op
Range(s) obo:BFO_0000034c

has qualityop # OPs

URI http://purl.obolibrary.org/obo/RO_0000086
Super-properties obo:RO_0000053op
Range(s) obo:BFO_0000019c

has roleop # OPs

URI http://purl.obolibrary.org/obo/RO_0000087
Description

A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
Super-properties obo:RO_0000053op
Range(s) obo:BFO_0000023c

occurent part ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0002012
Super-properties obo:BFO_0000050op
Inverse properties obo:TXPO_0002523op
Domain(s) obo:BFO_0000003c
Range(s) obo:BFO_0000003c

suppliesop # OPs

URI http://purl.obolibrary.org/obo/RO_0002178

has componentop # OPs

URI http://purl.obolibrary.org/obo/RO_0002180
Super-properties obo:BFO_0000051op
Inverse properties obo:TXPO_0000039op

regulatesop # OPs

URI http://purl.obolibrary.org/obo/RO_0002211
Inverse properties obo:RO_0002334op
Domain(s) obo:BFO_0000015c
Range(s) obo:BFO_0000015c

negatively regulatesop # OPs

URI http://purl.obolibrary.org/obo/RO_0002212
Super-properties obo:RO_0002211op
Inverse properties obo:RO_0002335op

positively regulatesop # OPs

URI http://purl.obolibrary.org/obo/RO_0002213
Super-properties obo:RO_0002211op
Inverse properties obo:RO_0002336op

has inputop # OPs

URI http://purl.obolibrary.org/obo/RO_0002233
Super-properties obo:RO_0000057op
Inverse properties obo:RO_0002352op

has outputop # OPs

URI http://purl.obolibrary.org/obo/RO_0002234
Super-properties obo:RO_0000057op
Inverse properties obo:RO_0002353op

regulated byop # OPs

URI http://purl.obolibrary.org/obo/RO_0002334
Domain(s) obo:BFO_0000015c
Range(s) obo:BFO_0000015c

negatively regulated byop # OPs

URI http://purl.obolibrary.org/obo/RO_0002335
Super-properties obo:RO_0002334op
Domain(s) obo:BFO_0000015c
Range(s) obo:BFO_0000015c

positively regulated byop # OPs

URI http://purl.obolibrary.org/obo/RO_0002336
Super-properties obo:RO_0002334op
Domain(s) obo:BFO_0000015c
Range(s) obo:BFO_0000015c

has target start locationop # OPs

URI http://purl.obolibrary.org/obo/RO_0002338

has target end locationop # OPs

URI http://purl.obolibrary.org/obo/RO_0002339

member ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0002350
Super-properties owl:topObjectProperty
Inverse properties obo:RO_0002351op

has memberop # OPs

URI http://purl.obolibrary.org/obo/RO_0002351
Super-properties owl:topObjectProperty

input ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0002352
Super-properties obo:RO_0000056op

output ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0002353
Super-properties obo:RO_0000056op

causally upstream of or withinop # OPs

URI http://purl.obolibrary.org/obo/RO_0002418
Super-properties obo:RO_0002501op

causally downstream of or withinop # OPs

URI http://purl.obolibrary.org/obo/RO_0002427
Super-properties obo:RO_0002501op

composed_primarily_ofop # OPs

URI http://purl.obolibrary.org/obo/RO_0002473
Super-properties obo:BFO_0000051op

causal relation between processesop # OPs

URI http://purl.obolibrary.org/obo/RO_0002501
Super-properties owl:topObjectProperty
Domain(s) obo:BFO_0000003c
Range(s) obo:BFO_0000003c

capable of regulatingop # OPs

URI http://purl.obolibrary.org/obo/RO_0002596
Super-properties owl:topObjectProperty
Range(s) http://purl.obolibrary.org/obo/BFO_0000015 http://purl.obolibrary.org/obo/CHEBI_24431

capable of positively regulatingop # OPs

URI http://purl.obolibrary.org/obo/RO_0002598
Super-properties obo:RO_0002596op
Range(s) obo:BFO_0000015c

capable of negatively regulatingop # OPs

URI http://purl.obolibrary.org/obo/RO_0002599
Super-properties obo:RO_0002596op
Range(s) obo:BFO_0000015c

has core processop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000004
Description

has core process
Super-properties owl:topObjectProperty
Range(s) obo:BFO_0000015c

metafuntioning type ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000005
Super-properties obo:RO_0000080op
Inverse properties obo:TXPO_0001870op

has molecular reactionop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000012
Super-properties obo:TXPO_0002523op
Inverse properties obo:TXPO_0000750op

finding ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000026
Super-properties owl:topObjectProperty
Inverse properties obo:TXPO_0001873op

component ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000039
Super-properties obo:BFO_0000050op

located_inop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000043
Super-properties owl:topObjectProperty
Range(s) obo:UBERON_0001062c

has resultop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000069
Super-properties obo:RO_0002427op
Inverse properties obo:TXPO_0000076op
Domain(s) obo:BFO_0000015c
Range(s) obo:BFO_0000015c

has causeop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000076
Super-properties obo:RO_0002418op
Domain(s) obo:BFO_0000015c
Range(s) obo:BFO_0000015c

relation between a role and a processop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000178

manifested phenotype ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000530
Inverse properties obo:TXPO_0000531op

manifests phenotypeop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000531
Domain(s) obo:BFO_0000015c

inheritop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000615

has family memberop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000683
Description

A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
Super-properties obo:RO_0002351op
Inverse properties obo:TXPO_0002260op

dysfunctioning ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000716
Super-properties obo:TXPO_0001518op
Inverse properties obo:TXPO_0003399op
Range(s) obo:TXPO_0000378c

molecular reaction ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000750
Super-properties obo:RO_0002012op

relateds assayop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000756
Super-properties owl:topObjectProperty
Inverse properties obo:TXPO_0001893op

has contextop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000774
Inverse properties obo:TXPO_0001887op
Range(s) obo:BFO_0000015c

has related human geneop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000819

has attribute valueop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0000826
Inverse properties obo:TXPO_0003479op
Domain(s) obo:TXPO_0000300c
Range(s) obo:TXPO_0000275c

hyperfunction ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001502
Super-properties obo:TXPO_0001518op

malfunctioning ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001518

has related rat geneop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001562

has stateop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001733
Super-properties owl:topObjectProperty

has attributeop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001862
Super-properties obo:RO_0000086op
Inverse properties obo:TXPO_0001872op
Domain(s) obo:BFO_0000001c
Range(s) obo:TXPO_0000300c

has agentop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001868
Super-properties obo:RO_0000057op
Inverse properties obo:TXPO_0001896op

metafunctioning typeop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001870
Super-properties obo:RO_0000086op

property ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001871
Super-properties obo:RO_0000080op

attribute ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001872
Super-properties obo:RO_0000080op

has findingop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001873
Super-properties owl:topObjectProperty
Domain(s) obo:BFO_0000015c
Range(s) obo:TXPO_0001503c

context ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001887

related assay ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001893
Super-properties owl:topObjectProperty

agent ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0001896
Super-properties obo:RO_0000056op

family ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0002260
Description

A protein family is a group of evolutionarily-related proteins. In many cases a protein family has a corresponding gene family.
Super-properties obo:RO_0002350op

has occurrent partop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0002523
Super-properties obo:BFO_0000051op

has pathwayop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0002524
Super-properties obo:TXPO_0002523op
Inverse properties obo:TXPO_0002525op
Range(s) obo:NCIT_C54214c

pathway ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0002525
Super-properties obo:RO_0002012op

is entity in organismop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0003360
Domain(s) obo:BFO_0000040c
Range(s) obo:OBI_0100026c

has dysfunctioningop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0003399
Super-properties owl:topObjectProperty
Range(s) obo:TXPO_0000145c

attribute value ofop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0003479

observed inop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0003500

realizes diseaseop # OPs

URI http://purl.obolibrary.org/obo/TXPO_0003585
Range(s) obo:DOID_4c

channel forop # OPs

URI http://purl.obolibrary.org/obo/uberon/core#channel_for
Domain(s) obo:UBERON_0004111c
Range(s) obo:UBERON_0000463c

Annotation Properties ↑

editor preferred termap # APs

URI http://purl.obolibrary.org/obo/IAO_0000111
Is Defined By http://purl.obolibrary.org/obo/iao.owl

example of usageap # APs

URI http://purl.obolibrary.org/obo/IAO_0000112
Is Defined By http://purl.obolibrary.org/obo/iao.owl

has curation statusap # APs

URI http://purl.obolibrary.org/obo/IAO_0000114

definitionap # APs

URI http://purl.obolibrary.org/obo/IAO_0000115
Is Defined By http://purl.obolibrary.org/obo/iao.owl

editor noteap # APs

URI http://purl.obolibrary.org/obo/IAO_0000116
Is Defined By http://purl.obolibrary.org/obo/iao.owl

term editorap # APs

URI http://purl.obolibrary.org/obo/IAO_0000117
Is Defined By http://purl.obolibrary.org/obo/iao.owl

alternative termap # APs

URI http://purl.obolibrary.org/obo/IAO_0000118
Is Defined By http://purl.obolibrary.org/obo/iao.owl

definition sourceap # APs

URI http://purl.obolibrary.org/obo/IAO_0000119
Is Defined By http://purl.obolibrary.org/obo/iao.owl

curator noteap # APs

URI http://purl.obolibrary.org/obo/IAO_0000232
Is Defined By http://purl.obolibrary.org/obo/iao.owl

imported fromap # APs

URI http://purl.obolibrary.org/obo/IAO_0000412
Is Defined By http://purl.obolibrary.org/obo/iao.owl

elucidationap # APs

URI http://purl.obolibrary.org/obo/IAO_0000600
Is Defined By http://purl.obolibrary.org/obo/iao.owl

has associated axiom(nl)ap # APs

URI http://purl.obolibrary.org/obo/IAO_0000601
Is Defined By http://purl.obolibrary.org/obo/iao.owl

has associated axiom(fol)ap # APs

URI http://purl.obolibrary.org/obo/IAO_0000602
Is Defined By http://purl.obolibrary.org/obo/iao.owl

has axiom labelap # APs

URI http://purl.obolibrary.org/obo/IAO_0010000
Is Defined By http://purl.obolibrary.org/obo/iao.owl

symbol from nomenclature authorityap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000004

full name from nomenclature authorityap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000005

NCBI GeneIDap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000006

NCBI LocusTagap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000007

gene map locationap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000008

OGG_0000000009ap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000009

organism NCBITaxon IDap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000015

chromosome ID of geneap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000017

OGG_0000000018ap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000018

nomenclature statusap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000019

has GO associationap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000029

has PubMed associationap # APs

URI http://purl.obolibrary.org/obo/OGG_0000000030

is opposite_ofap # APs

URI http://purl.obolibrary.org/obo/RO_0002604

external definitionap # APs

URI http://purl.obolibrary.org/obo/UBPROP_0000001

homology notesap # APs

URI http://purl.obolibrary.org/obo/UBPROP_0000003
Description

This annotation property may be replaced with an annotation property from an external ontology such as IAO

taxon notesap # APs

URI http://purl.obolibrary.org/obo/UBPROP_0000008

function_notesap # APs

URI http://purl.obolibrary.org/obo/UBPROP_0000009

structure_notesap # APs

URI http://purl.obolibrary.org/obo/UBPROP_0000010

development_notesap # APs

URI http://purl.obolibrary.org/obo/UBPROP_0000011

fma_set_termap # APs

URI http://purl.obolibrary.org/obo/UBPROP_0000202

formulaap # APs

URI http://purl.obolibrary.org/obo/chebi/formula

smilesap # APs

URI http://purl.obolibrary.org/obo/chebi/smiles

contributorap # APs

URI http://purl.org/dc/elements/1.1/contributor

creatorap # APs

URI http://purl.org/dc/elements/1.1/creator

dateap # APs

URI http://purl.org/dc/elements/1.1/date

descriptionap # APs

URI http://purl.org/dc/elements/1.1/description

formatap # APs

URI http://purl.org/dc/elements/1.1/format

identifierap # APs

URI http://purl.org/dc/elements/1.1/identifier

Languageap # APs

URI http://purl.org/dc/elements/1.1/language
Is Defined By http://purl.org/dc/elements/1.1/

licenseap # APs

URI http://purl.org/dc/elements/1.1/license

memberap # APs

URI http://purl.org/dc/elements/1.1/member

sourceap # APs

URI http://purl.org/dc/elements/1.1/source

subjectap # APs

URI http://purl.org/dc/elements/1.1/subject

titleap # APs

URI http://purl.org/dc/elements/1.1/title

auto-generated-byap # APs

URI http://www.geneontology.org/formats/oboInOwl#auto-generated-by

dateap # APs

URI http://www.geneontology.org/formats/oboInOwl#date

default-namespaceap # APs

URI http://www.geneontology.org/formats/oboInOwl#default-namespace

has_alternative_idap # APs

URI http://www.geneontology.org/formats/oboInOwl#hasAlternativeId

hasBroadSynonymap # APs

URI http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym

database_cross_referenceap # APs

URI http://www.geneontology.org/formats/oboInOwl#hasDbXref

has_exact_synonymap # APs

URI http://www.geneontology.org/formats/oboInOwl#hasExactSynonym

has_narrow_synonymap # APs

URI http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym

hasOBONamespaceap # APs

URI http://www.geneontology.org/formats/oboInOwl#hasOBONamespace

idap # APs

URI http://www.geneontology.org/formats/oboInOwl#id

saved-byap # APs

URI http://www.geneontology.org/formats/oboInOwl#saved-by

commentap # APs

URI http://www.w3.org/2000/01/rdf-schema#comment

isDefinedByap # APs

URI http://www.w3.org/2000/01/rdf-schema#isDefinedBy

labelap # APs

URI http://www.w3.org/2000/01/rdf-schema#label

seeAlsoap # APs

URI http://www.w3.org/2000/01/rdf-schema#seeAlso

prefLabelap # APs

URI http://www.w3.org/2004/02/skos/core#prefLabel

depicted_byap # APs

URI http://xmlns.com/foaf/0.1/depicted_by

homepageap # APs

URI http://xmlns.com/foaf/0.1/homepage

Namespaces ↑

default (:)
http://purl.obolibrary.org/obo/txpo.owl
chebi
http://purl.obolibrary.org/obo/chebi/
core
http://purl.obolibrary.org/obo/uberon/core#
dbo
http://dbpedia.org/ontology/
dc
http://purl.org/dc/elements/1.1/
dct
http://purl.org/dc/terms/
efo
http://www.ebi.ac.uk/efo/
foaf
http://xmlns.com/foaf/0.1/
meat
http://example.com/
ncicp
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
obo
http://purl.obolibrary.org/obo/
oboInOwl
http://www.geneontology.org/formats/oboInOwl#
owl
http://www.w3.org/2002/07/owl#
prov
http://www.w3.org/ns/prov#
rdf
http://www.w3.org/1999/02/22-rdf-syntax-ns#
rdfs
http://www.w3.org/2000/01/rdf-schema#
sdo
https://schema.org/
skos
http://www.w3.org/2004/02/skos/core#
uberon
http://purl.obolibrary.org/obo/uberon#
wiki
http://en.wikipedia.org/wiki/
xsd
http://www.w3.org/2001/XMLSchema#

Legend

cClasses
opObject Properties
fpFunctional Properties
dpData Properties
dpAnnotation Properties
pProperties
niNamed Individuals