@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix : <http://purl.obolibrary.org/obo/vo.owl#> .
@prefix dc: <http://purl.org/dc/elements/1.1/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xml: <http://www.w3.org/XML/1998/namespace> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix chebi: <http://purl.obolibrary.org/obo/chebi/> .
@prefix terms: <http://purl.org/dc/terms/> .
@prefix owl2xml: <http://www.w3.org/2006/12/owl2-xml#> .
@prefix protege: <http://protege.stanford.edu/plugins/owl/protege#> .
@prefix oboInOwl: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ncbitaxon: <http://purl.obolibrary.org/obo/ncbitaxon#> .

protege:defaultLanguage
    a owl:AnnotationProperty .

obo:BFO_0000001
    obo:BFO_0000179 "entity" ;
    obo:BFO_0000180 "Entity" ;
    obo:IAO_0000112 "Julius Caesar"@en, "Verdi’s Requiem"@en, "the Second World War"@en, "your body mass index"@en ;
    obo:IAO_0000116 "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81"@en, "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"@en ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl>, <http://purl.obolibrary.org/obo/ogms.owl> ;
    obo:IAO_0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])"@en ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "entity", "entity"@en .

obo:BFO_0000002
    obo:BFO_0000179 "continuant" ;
    obo:BFO_0000180 "Continuant" ;
    obo:IAO_0000111 "continuant"@en ;
    obo:IAO_0000115 "An entity  that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en, "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts."@en ;
    obo:IAO_0000116 "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240"@en, "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants"@en ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl>, <http://purl.obolibrary.org/obo/pato.owl> ;
    obo:IAO_0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])"@en ;
    obo:IAO_0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])"@en, "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])"@en, "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])"@en ;
    obo:IAO_0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] ", "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] ", "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] ", "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "continuant", "continuant"@en ;
    rdfs:subClassOf obo:BFO_0000001 .

obo:BFO_0000003
    obo:BFO_0000179 "occurrent" ;
    obo:BFO_0000180 "Occurrent" ;
    obo:IAO_0000115 "An entity that has temporal parts and that happens, unfolds or develops through time."@en ;
    obo:IAO_0000116 "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region"@en, "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players."@en, "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process."@en, "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000600 "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])"@en ;
    obo:IAO_0000601 "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])"@en, "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])"@en ;
    obo:IAO_0000602 "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] ", "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "occurrent"@en ;
    rdfs:subClassOf obo:BFO_0000001 .

obo:BFO_0000004
    obo:BFO_0000179 "ic" ;
    obo:BFO_0000180 "IndependentContinuant" ;
    obo:IAO_0000112 "a chair"@en, "a heart"@en, "a leg"@en, "a molecule"@en, "a spatial region"@en, "an atom"@en, "an orchestra."@en, "an organism"@en, "the bottom right portion of a human torso"@en, "the interior of your mouth"@en ;
    obo:IAO_0000115 "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."@en, "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])"@en, "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])"@en ;
    obo:IAO_0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] ", "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] ", "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "independent continuant"@en ;
    rdfs:subClassOf obo:BFO_0000002 .

obo:BFO_0000006
    obo:BFO_0000179 "s-region" ;
    obo:BFO_0000180 "SpatialRegion" ;
    obo:IAO_0000116 "BFO 2 Reference: Spatial regions do not participate in processes."@en, "Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000600 "A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])"@en ;
    obo:IAO_0000601 "All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])"@en ;
    obo:IAO_0000602 "(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] ", "(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "spatial region"@en ;
    rdfs:subClassOf obo:BFO_0000141 .

obo:BFO_0000007
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/obi.owl> .

obo:BFO_0000008
    obo:BFO_0000179 "t-region" ;
    obo:BFO_0000180 "TemporalRegion" ;
    obo:IAO_0000116 "Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000600 "A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])"@en ;
    obo:IAO_0000601 "All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])"@en, "Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])"@en ;
    obo:IAO_0000602 "(forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] ", "(forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] ", "(forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "temporal region"@en ;
    rdfs:subClassOf obo:BFO_0000003 .

obo:BFO_0000009
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000011
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000015
    obo:BFO_0000179 "process" ;
    obo:BFO_0000180 "Process" ;
    obo:IAO_0000112 "a process of cell-division, \\ a beating of the heart"@en, "a process of meiosis"@en, "a process of sleeping"@en, "the course of a disease"@en, "the flight of a bird"@en, "the life of an organism"@en, "your process of aging."@en ;
    obo:IAO_0000115 "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."@en, "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en ;
    obo:IAO_0000116 "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)"@en ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000602 "(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "process"@en ;
    rdfs:subClassOf obo:BFO_0000003 .

obo:BFO_0000016
    obo:BFO_0000179 "disposition" ;
    obo:BFO_0000180 "Disposition" ;
    obo:IAO_0000112 "an atom of element X has the disposition to decay to an atom of element Y"@en, "certain people have a predisposition to colon cancer"@en, "children are innately disposed to categorize objects in certain ways."@en, "the cell wall is disposed to filter chemicals in endocytosis and exocytosis"@en ;
    obo:IAO_0000116 "BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000600 "b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])"@en ;
    obo:IAO_0000601 "If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])"@en ;
    obo:IAO_0000602 "(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] ", "(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "disposition"@en ;
    rdfs:subClassOf obo:BFO_0000017 .

obo:BFO_0000017
    obo:BFO_0000179 "realizable" ;
    obo:BFO_0000180 "RealizableEntity" ;
    obo:IAO_0000112 "the disposition of this piece of metal to conduct electricity."@en, "the disposition of your blood to coagulate"@en, "the function of your reproductive organs"@en, "the role of being a doctor"@en, "the role of this boundary to delineate where Utah and Colorado meet"@en ;
    obo:IAO_0000115 "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000600 "To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])"@en ;
    obo:IAO_0000601 "All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])"@en ;
    obo:IAO_0000602 "(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] ", "(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "realizable entity"@en ;
    rdfs:subClassOf obo:BFO_0000020 .

obo:BFO_0000018
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000019
    obo:BFO_0000179 "quality" ;
    obo:BFO_0000180 "Quality" ;
    obo:IAO_0000111 "quality"@en ;
    obo:IAO_0000112 "the ambient temperature of this portion of air"@en, "the color of a tomato"@en, "the length of the circumference of your waist"@en, "the mass of this piece of gold."@en, "the shape of your nose"@en, "the shape of your nostril"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl>, <http://purl.obolibrary.org/obo/pato.owl> ;
    obo:IAO_0000600 "a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])"@en ;
    obo:IAO_0000601 "If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])"@en ;
    obo:IAO_0000602 "(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] ", "(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "quality"@en ;
    rdfs:subClassOf obo:BFO_0000020 .

obo:BFO_0000020
    obo:BFO_0000179 "sdc" ;
    obo:BFO_0000180 "SpecificallyDependentContinuant" ;
    obo:IAO_0000111 "specifically dependent continuant"@en ;
    obo:IAO_0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key"@en, "of one-sided specifically dependent continuants: the mass of this tomato"@en, "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates."@en, "the disposition of this fish to decay"@en, "the function of this heart: to pump blood"@en, "the mutual dependence of proton donors and acceptors in chemical reactions [79"@en, "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction"@en, "the pink color of a medium rare piece of grilled filet mignon at its center"@en, "the role of being a doctor"@en, "the shape of this hole."@en, "the smell of this portion of mozzarella"@en ;
    obo:IAO_0000115 "A continuant  that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en, "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en, "b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1  i &lt; j  n, ci  and cj share no common parts, are such that for each 1  i  n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])"@en, "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en ;
    obo:IAO_0000116 "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl>, <http://purl.obolibrary.org/obo/pato.owl> ;
    obo:IAO_0000602 "(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] ", "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "specifically dependent continuant"@en ;
    rdfs:subClassOf obo:BFO_0000002 .

obo:BFO_0000023
    obo:BFO_0000179 "role" ;
    obo:BFO_0000180 "Role" ;
    obo:IAO_0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married."@en, "the priest role"@en, "the role of a boundary to demarcate two neighboring administrative territories"@en, "the role of a building in serving as a military target"@en, "the role of a stone in marking a property boundary"@en, "the role of subject in a clinical trial"@en, "the student role"@en ;
    obo:IAO_0000115 "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts."@en ;
    obo:IAO_0000116 "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals –  professor, sergeant, nurse – only during certain phases in their lives."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000600 "b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])"@en ;
    obo:IAO_0000602 "(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "role"@en ;
    rdfs:subClassOf obo:BFO_0000017 .

obo:BFO_0000024
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000026
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000027
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000028
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000029
    obo:BFO_0000179 "site" ;
    obo:BFO_0000180 "Site" ;
    obo:IAO_0000112 "Manhattan Canyon)"@en, "a hole in the interior of a portion of cheese"@en, "a rabbit hole"@en, "an air traffic control region defined in the airspace above an airport"@en, "the Grand Canyon"@en, "the Piazza San Marco"@en, "the cockpit of an aircraft"@en, "the hold of a ship"@en, "the interior of a kangaroo pouch"@en, "the interior of the trunk of your car"@en, "the interior of your bedroom"@en, "the interior of your office"@en, "the interior of your refrigerator"@en, "the lumen of your gut"@en, "your left nostril (a fiat part – the opening – of your left nasal cavity)"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    obo:IAO_0000600 "b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])"@en ;
    obo:IAO_0000602 "(forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "site"@en ;
    rdfs:subClassOf obo:BFO_0000141 .

obo:BFO_0000030
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000031
    obo:BFO_0000179 "gdc" ;
    obo:BFO_0000180 "GenericallyDependentContinuant" ;
    obo:IAO_0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity."@en, "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop"@en, "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule."@en ;
    obo:IAO_0000115 "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en, "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000602 "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "generically dependent continuant"@en ;
    rdfs:subClassOf obo:BFO_0000002 .

obo:BFO_0000034
    obo:BFO_0000179 "function" ;
    obo:BFO_0000180 "Function" ;
    obo:IAO_0000112 "the function of a hammer to drive in nails"@en, "the function of a heart pacemaker to regulate the beating of a heart through electricity"@en, "the function of amylase in saliva to break down starch into sugar"@en ;
    obo:IAO_0000116 "BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    obo:IAO_0000600 "A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])"@en ;
    obo:IAO_0000602 "(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "function"@en ;
    rdfs:subClassOf obo:BFO_0000016 .

obo:BFO_0000035
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000038
    obo:BFO_0000179 "1d-t-region" ;
    obo:BFO_0000180 "OneDimensionalTemporalRegion" ;
    obo:IAO_0000112 "the temporal region during which a process occurs."@en ;
    obo:IAO_0000116 "BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks)."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    obo:IAO_0000600 "A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])"@en ;
    obo:IAO_0000602 "(forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "one-dimensional temporal region"@en ;
    rdfs:subClassOf obo:BFO_0000008 .

obo:BFO_0000040
    obo:BFO_0000179 "material" ;
    obo:BFO_0000180 "MaterialEntity" ;
    obo:IAO_0000112 "a flame"@en, "a forest fire"@en, "a human being"@en, "a hurricane"@en, "a photon"@en, "a puff of smoke"@en, "a sea wave"@en, "a tornado"@en, "an aggregate of human beings."@en, "an energy wave"@en, "an epidemic"@en, "the undetached arm of a human being"@en ;
    obo:IAO_0000115 "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time."@en ;
    obo:IAO_0000116 "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60"@en, "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity."@en, "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here."@en ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:IAO_0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])"@en ;
    obo:IAO_0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])"@en, "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])"@en ;
    obo:IAO_0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] ", "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] ", "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "material entity"@en ;
    rdfs:subClassOf obo:BFO_0000004 .

obo:BFO_0000050
    obo:IAO_0000111 "is part of"@en ;
    obo:IAO_0000112 "my brain is part of my body (continuant parthood, two material entities)"@en, "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)"@en, "this day is part of this year (occurrent parthood)"@en ;
    obo:IAO_0000115 "a core relation that holds between a part and its whole"@en ;
    obo:IAO_0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other."@en, "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime"@en, """Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)

A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'."""@en ;
    obo:IAO_0000118 "part_of"@en ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "part of"@en ;
    rdfs:seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" ;
    owl:inverseOf obo:BFO_0000051 .

obo:BFO_0000051
    obo:IAO_0000111 "has part"@en ;
    obo:IAO_0000112 "my body has part my brain (continuant parthood, two material entities)"@en, "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)"@en, "this year has part this day (occurrent parthood)"@en ;
    obo:IAO_0000115 "a core relation that holds between a whole and its part"@en ;
    obo:IAO_0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part."@en, "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime"@en, """Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)

A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'."""@en ;
    obo:IAO_0000118 "has_part"@en ;
    obo:IAO_0000412 obo:BFO, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "has part"@en .

obo:BFO_0000053
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000054
    obo:IAO_0000111 "realized in"@en ;
    obo:IAO_0000112 "this disease is realized in this disease course"@en, "this fragility is realized in this shattering"@en, "this investigator role is realized in this investigation"@en ;
    obo:IAO_0000118 "is realized by"@en, "realized_in"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000600 "[copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])"@en ;
    a owl:ObjectProperty ;
    rdfs:comment "Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
    rdfs:domain obo:BFO_0000017 ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "realized in"@en ;
    rdfs:range obo:BFO_0000015 ;
    owl:inverseOf obo:BFO_0000055 .

obo:BFO_0000055
    obo:IAO_0000111 "realizes"@en ;
    obo:IAO_0000112 "this disease course realizes this disease"@en, "this investigation realizes this investigator role"@en, "this shattering realizes this fragility"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000600 "to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])"@en ;
    a owl:ObjectProperty ;
    rdfs:comment "Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process" ;
    rdfs:domain obo:BFO_0000015 ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl>, <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "realizes"@en ;
    rdfs:range obo:BFO_0000017 .

obo:BFO_0000056
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "participates_in" .

obo:BFO_0000058
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000059
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000062
    obo:IAO_0000111 "preceded by"@en ;
    obo:IAO_0000115 "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
    obo:IAO_0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other."@en ;
    obo:IAO_0000118 "is preceded by"@en, "preceded_by"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    dc:source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "preceded by"@en .

obo:BFO_0000063
    obo:IAO_0000111 "precedes"@en ;
    obo:IAO_0000115 "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "precedes"@en .

obo:BFO_0000066
    obo:IAO_0000111 "occurs in"@en ;
    obo:IAO_0000115 "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t"@en ;
    obo:IAO_0000118 "occurs_in"@en, "unfolds in"@en, "unfolds_in"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:comment "Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant" ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "occurs in"@en .

obo:BFO_0000067
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000070
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000079
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000080
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000081
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000083
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000084
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000101
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000107
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000108
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000111
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000112
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000113
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000115
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000117
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000118
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000119
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000121
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000123
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000124
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000125
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000126
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000127
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000129
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000130
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000132
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000133
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000136
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000137
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000138
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000139
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000140
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000141
    obo:BFO_0000179 "immaterial" ;
    obo:BFO_0000180 "ImmaterialEntity" ;
    obo:IAO_0000116 "BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "immaterial entity"@en ;
    rdfs:subClassOf obo:BFO_0000004 .

obo:BFO_0000142
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000144
    obo:BFO_0000179 "process-profile" ;
    obo:BFO_0000180 "ProcessProfile" ;
    obo:IAO_0000112 "On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels"@en, "One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from   rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance."@en, "The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on."@en ;
    obo:IAO_0000115 "b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    obo:IAO_0000600 "b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])"@en ;
    obo:IAO_0000602 "(forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] ", "(iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] " ;
    a owl:Class ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> ;
    rdfs:label "process profile"@en ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:BFO_0000145
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000146
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000147
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000148
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000151
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000152
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000153
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000154
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000155
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000156
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000157
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000158
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000160
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000162
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000163
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000164
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000165
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000166
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000167
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000168
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000169
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000170
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000171
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000172
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000173
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000174
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000175
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000176
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000177
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000178
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000179
    obo:IAO_0000115 "Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification."@en ;
    obo:IAO_0000232 "Really of interest to developers only"@en ;
    a owl:AnnotationProperty ;
    rdfs:label "BFO OWL specification label", "BFO OWL specification label"@en ;
    rdfs:subPropertyOf rdfs:label .

obo:BFO_0000180
    obo:IAO_0000115 "Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2"@en ;
    obo:IAO_0000119 "Person:Alan Ruttenberg" ;
    obo:IAO_0000232 "Really of interest to developers only"@en ;
    a owl:AnnotationProperty ;
    rdfs:label "BFO CLIF specification label", "BFO CLIF specification label"@en ;
    rdfs:subPropertyOf rdfs:label .

obo:BFO_0000181
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000182
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000184
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000185
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000186
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:BFO_0000187
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/bfo.owl> .

obo:CARO_0000003
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CARO_0000006
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CARO_0000014
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CARO_0000043
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CARO_0000055
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CARO_0001000
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CARO_0001001
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CARO_0010000
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/caro.owl> .

obo:CHEBI_15882
    obo:IAO_0000115 "An organic hydroxy compound that consists of benzene bearing a single hydroxy substituent. The parent of the class of phenols."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C6H6O"^^xsd:string ;
    chebi:inchi "InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H"^^xsd:string ;
    chebi:inchikey "ISWSIDIOOBJBQZ-UHFFFAOYSA-N"^^xsd:string ;
    chebi:mass "94.11120"^^xsd:string ;
    chebi:monoisotopicmass "94.04186"^^xsd:string ;
    chebi:smiles "Oc1ccccc1"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:14777"^^xsd:string, "CHEBI:25966"^^xsd:string, "CHEBI:43543"^^xsd:string, "CHEBI:8071"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:969616"^^xsd:string, "CAS:108-95-2"^^xsd:string, "DrugBank:DB03255"^^xsd:string, "Drug_Central:4266"^^xsd:string, "Gmelin:2794"^^xsd:string, "HMDB:HMDB0000228"^^xsd:string, "KEGG:C00146"^^xsd:string, "KEGG:C15584"^^xsd:string, "KEGG:D00033"^^xsd:string, "KEGG:D06536"^^xsd:string, "KNApSAcK:C00002664"^^xsd:string, "PDBeChem:IPH"^^xsd:string, "PMID:12058733"^^xsd:string, "PMID:16953321"^^xsd:string, "PMID:17852157"^^xsd:string, "PMID:19029204"^^xsd:string, "PMID:20886261"^^xsd:string, "PMID:21492257"^^xsd:string, "PMID:21689881"^^xsd:string, "PMID:21809019"^^xsd:string, "PMID:21822930"^^xsd:string, "Reaxys:969616"^^xsd:string, "UM-BBD_compID:c0128"^^xsd:string, "Wikipedia:Phenol"^^xsd:string ;
    oboInOwl:hasExactSynonym "PHENOL"^^xsd:string, "Phenol"^^xsd:string, "phenol"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Benzenol"^^xsd:string, "Carbolsaeure"^^xsd:string, "Hydroxybenzene"^^xsd:string, "Karbolsaeure"^^xsd:string, "Oxybenzene"^^xsd:string, "PhOH"^^xsd:string, "Phenic acid"^^xsd:string, "Phenylic acid"^^xsd:string, "Phenylic alcohol"^^xsd:string, "acide carbolique"^^xsd:string, "acide phenique"^^xsd:string, "carbolic acid"^^xsd:string ;
    oboInOwl:id "CHEBI:15882"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "phenol"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_16199
    obo:IAO_0000115 "A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O)."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "CH4N2O"^^xsd:string ;
    chebi:inchi "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)"^^xsd:string ;
    chebi:inchikey "XSQUKJJJFZCRTK-UHFFFAOYSA-N"^^xsd:string ;
    chebi:mass "60.05534"^^xsd:string ;
    chebi:monoisotopicmass "60.03236"^^xsd:string ;
    chebi:smiles "NC(N)=O"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:15292"^^xsd:string, "CHEBI:27218"^^xsd:string, "CHEBI:46379"^^xsd:string, "CHEBI:9888"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:635724"^^xsd:string, "CAS:57-13-6"^^xsd:string, "DrugBank:DB03904"^^xsd:string, "Drug_Central:4264"^^xsd:string, "ECMDB:ECMDB04172"^^xsd:string, "Gmelin:1378"^^xsd:string, "HMDB:HMDB0000294"^^xsd:string, "KEGG:C00086"^^xsd:string, "KEGG:D00023"^^xsd:string, "KNApSAcK:C00007314"^^xsd:string, "MetaCyc:UREA"^^xsd:string, "PDBeChem:URE"^^xsd:string, "PMID:18037357"^^xsd:string, "PMID:22770225"^^xsd:string, "PPDB:1728"^^xsd:string, "Reaxys:635724"^^xsd:string, "UM-BBD_compID:c0165"^^xsd:string, "Wikipedia:Urea"^^xsd:string, "YMDB:YMDB00003"^^xsd:string ;
    oboInOwl:hasExactSynonym "UREA"^^xsd:string, "Urea"^^xsd:string, "urea"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "1728"^^xsd:string, "Carbamide"^^xsd:string, "E927b"^^xsd:string, "H2NC(O)NH2"^^xsd:string, "Harnstoff"^^xsd:string, "Karbamid"^^xsd:string, "carbamide"^^xsd:string, "carbonyldiamide"^^xsd:string, "ur"^^xsd:string, "uree"^^xsd:string ;
    oboInOwl:id "CHEBI:16199"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "urea"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_16412
    obo:IAO_0000115 "Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria)."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    oboInOwl:hasAlternativeId "CHEBI:14520"^^xsd:string, "CHEBI:25062"^^xsd:string, "CHEBI:6494"^^xsd:string ;
    oboInOwl:hasDbXref "KEGG:C00338"^^xsd:string, "PMID:15589368"^^xsd:string, "PMID:24186868"^^xsd:string, "PMID:24506665"^^xsd:string, "PMID:24642373"^^xsd:string, "PMID:24659348"^^xsd:string ;
    oboInOwl:hasExactSynonym "Lipopolysaccharide"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "LPS"^^xsd:string, "lipopolysaccharides"^^xsd:string ;
    oboInOwl:id "CHEBI:16412"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "lipopolysaccharide"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_16670
    obo:IAO_0000115 "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "(C2H2NOR)nC2H3NOR"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:14753"^^xsd:string, "CHEBI:25906"^^xsd:string, "CHEBI:7990"^^xsd:string ;
    oboInOwl:hasDbXref "KEGG:C00012"^^xsd:string ;
    oboInOwl:hasExactSynonym "Peptide"^^xsd:string, "peptides"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Peptid"^^xsd:string, "peptido"^^xsd:string, "peptidos"^^xsd:string ;
    oboInOwl:id "CHEBI:16670"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "peptide"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_16842
    obo:IAO_0000115 "An aldehyde resulting from the formal oxidation of methanol."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "CH2O"^^xsd:string ;
    chebi:inchi "InChI=1S/CH2O/c1-2/h1H2"^^xsd:string ;
    chebi:inchikey "WSFSSNUMVMOOMR-UHFFFAOYSA-N"^^xsd:string ;
    chebi:mass "30.02598"^^xsd:string ;
    chebi:monoisotopicmass "30.01056"^^xsd:string ;
    chebi:smiles "[H]C([H])=O"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:14274"^^xsd:string, "CHEBI:24077"^^xsd:string, "CHEBI:337763"^^xsd:string, "CHEBI:5142"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:1209228"^^xsd:string, "CAS:50-00-0"^^xsd:string, "DrugBank:DB03843"^^xsd:string, "Drug_Central:3244"^^xsd:string, "Gmelin:445"^^xsd:string, "HMDB:HMDB0001426"^^xsd:string, "KEGG:C00067"^^xsd:string, "KEGG:D00017"^^xsd:string, "MetaCyc:FORMALDEHYDE"^^xsd:string, "PDBeChem:FOR"^^xsd:string, "PMID:110589"^^xsd:string, "PMID:12686735"^^xsd:string, "PMID:15091529"^^xsd:string, "PMID:16423181"^^xsd:string, "PMID:17618393"^^xsd:string, "PMID:18837732"^^xsd:string, "PMID:25042713"^^xsd:string, "PMID:7381846"^^xsd:string, "PMID:7548723"^^xsd:string, "PMID:7689168"^^xsd:string, "PMID:7896413"^^xsd:string, "PMID:9686972"^^xsd:string, "PPDB:359"^^xsd:string, "Reaxys:1209228"^^xsd:string, "UM-BBD_compID:c0122"^^xsd:string, "Wikipedia:Formaldehyde"^^xsd:string ;
    oboInOwl:hasExactSynonym "FORMALDEHYDE"^^xsd:string, "Formaldehyde"^^xsd:string, "formaldehyde"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "FORMALIN"^^xsd:string, "Formaldehyd"^^xsd:string, "Formalin"^^xsd:string, "Methanal"^^xsd:string, "Methylene oxide"^^xsd:string, "Oxomethane"^^xsd:string, "Oxomethylene"^^xsd:string ;
    oboInOwl:id "CHEBI:16842"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "formaldehyde"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_17076
    obo:IAO_0000115 "A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C21H39N7O12"^^xsd:string ;
    chebi:inchi "InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1"^^xsd:string ;
    chebi:inchikey "UCSJYZPVAKXKNQ-HZYVHMACSA-N"^^xsd:string ;
    chebi:mass "581.57434"^^xsd:string ;
    chebi:monoisotopicmass "581.26567"^^xsd:string ;
    chebi:smiles "CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@@H](O[C@@H](C)[C@]1(O)C=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]1NC(N)=N"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:15119"^^xsd:string, "CHEBI:26784"^^xsd:string, "CHEBI:45745"^^xsd:string, "CHEBI:9284"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:74498"^^xsd:string, "CAS:57-92-1"^^xsd:string, "DrugBank:DB01082"^^xsd:string, "Drug_Central:2481"^^xsd:string, "HMDB:HMDB0015214"^^xsd:string, "KEGG:C00413"^^xsd:string, "KEGG:D08531"^^xsd:string, "MetaCyc:STREPTOMYCIN"^^xsd:string, "PDBeChem:SRY"^^xsd:string, "PMID:11228320"^^xsd:string, "PMID:11905029"^^xsd:string, "PMID:12118520"^^xsd:string, "PMID:13030054"^^xsd:string, "PMID:13116094"^^xsd:string, "PMID:13136149"^^xsd:string, "PMID:13596285"^^xsd:string, "PMID:13691614"^^xsd:string, "PMID:13985260"^^xsd:string, "PMID:13990247"^^xsd:string, "PMID:14623118"^^xsd:string, "PMID:14828344"^^xsd:string, "PMID:14852338"^^xsd:string, "PMID:14939639"^^xsd:string, "PMID:15081082"^^xsd:string, "PMID:15137533"^^xsd:string, "PMID:15207172"^^xsd:string, "PMID:15686853"^^xsd:string, "PMID:15736038"^^xsd:string, "PMID:16904706"^^xsd:string, "PMID:17105735"^^xsd:string, "PMID:17238915"^^xsd:string, "PMID:17429930"^^xsd:string, "PMID:18173084"^^xsd:string, "PMID:18916143"^^xsd:string, "PMID:19052412"^^xsd:string, "PMID:19335957"^^xsd:string, "PMID:21350946"^^xsd:string, "PMID:21362244"^^xsd:string, "PMID:21593257"^^xsd:string, "PMID:21937264"^^xsd:string, "PMID:22101040"^^xsd:string, "Pesticides:streptomycin"^^xsd:string, "Reaxys:74498"^^xsd:string, "Wikipedia:Streptomycin"^^xsd:string ;
    oboInOwl:hasExactSynonym "N,N'''-[(1R,2R,3S,4R,5R,6S)-4-{5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyloxy}-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine"^^xsd:string, "STREPTOMYCIN"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside"^^xsd:string, "Kantrex"^^xsd:string, "SM"^^xsd:string, "[2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}"^^xsd:string, "streomycin"^^xsd:string, "streptomycin"^^xsd:string ;
    oboInOwl:id "CHEBI:17076"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "streptomycin"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_17716
    obo:IAO_0000115 "A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C12H22O11"^^xsd:string ;
    chebi:inchi "InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1"^^xsd:string ;
    chebi:inchikey "GUBGYTABKSRVRQ-QKKXKWKRSA-N"^^xsd:string ;
    chebi:mass "342.297"^^xsd:string ;
    chebi:monoisotopicmass "342.11621"^^xsd:string ;
    chebi:smiles "OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:10296"^^xsd:string, "CHEBI:10380"^^xsd:string, "CHEBI:14497"^^xsd:string, "CHEBI:22460"^^xsd:string, "CHEBI:22760"^^xsd:string, "CHEBI:25005"^^xsd:string, "CHEBI:27755"^^xsd:string, "CHEBI:613009"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:1292745"^^xsd:string, "CAS:63-42-3"^^xsd:string, "GlyGen:G74621DY"^^xsd:string, "GlyTouCan:G74621DY"^^xsd:string, "Gmelin:882872"^^xsd:string, "KEGG:C00243"^^xsd:string, "KEGG:D00046"^^xsd:string, "KEGG:G10504"^^xsd:string, "KNApSAcK:C00001136"^^xsd:string, "PMID:1292745"^^xsd:string, "PMID:17329833"^^xsd:string, "PMID:18300214"^^xsd:string, "PMID:19053747"^^xsd:string, "PMID:19846069"^^xsd:string, "PMID:19913595"^^xsd:string, "PMID:20094999"^^xsd:string, "PMID:20503067"^^xsd:string, "PMID:20699559"^^xsd:string, "PMID:20873837"^^xsd:string, "PMID:20961532"^^xsd:string, "PMID:21403918"^^xsd:string, "PMID:2432147"^^xsd:string, "PMID:2456994"^^xsd:string, "PMID:28690131"^^xsd:string, "PMID:28807538"^^xsd:string, "PMID:6194884"^^xsd:string, "PMID:7574700"^^xsd:string, "Reaxys:1292745"^^xsd:string ;
    oboInOwl:hasExactSynonym "beta-D-galactopyranosyl-(1->4)-D-glucopyranose"^^xsd:string, "lactose"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "(+)-lactose"^^xsd:string, "(Gal)1 (Glc)1"^^xsd:string, "1-beta-D-Galactopyranosyl-4-D-glucopyranose"^^xsd:string, "4-(beta-D-galactosido)-D-glucose"^^xsd:string, "4-O-beta-D-galactopyranosyl-D-glucose"^^xsd:string, "D-lactose"^^xsd:string, "Galbeta1-4Glc"^^xsd:string, "Lac"^^xsd:string, "Laktobiose"^^xsd:string, "Laktose"^^xsd:string, "Milchzucker"^^xsd:string, "Milk sugar"^^xsd:string, "WURCS=2.0/2,2,1/[a2122h-1x_1-5][a2112h-1b_1-5]/1-2/a4-b1"^^xsd:string, "beta-D-Gal-(1->4)-D-Glc"^^xsd:string, "beta-D-Galp-(1->4)-D-Glcp"^^xsd:string, "beta-Gal1,4-Glc"^^xsd:string, "lactobiose"^^xsd:string, "milk sugar"^^xsd:string ;
    oboInOwl:id "CHEBI:17716"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "lactose"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_17833
    obo:IAO_0000115 "Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    oboInOwl:hasAlternativeId "CHEBI:14293"^^xsd:string, "CHEBI:24206"^^xsd:string, "CHEBI:24212"^^xsd:string, "CHEBI:5306"^^xsd:string ;
    oboInOwl:hasDbXref "CAS:1403-66-3"^^xsd:string, "DrugBank:DB00798"^^xsd:string, "KEGG:C00505"^^xsd:string ;
    oboInOwl:hasExactSynonym "4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)pentopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)heptopyranoside"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Gentamicin"^^xsd:string, "gentamycins"^^xsd:string ;
    oboInOwl:id "CHEBI:17833"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "gentamycin"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_17992
    obo:IAO_0000115 "A glycosyl glycoside formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C12H22O11"^^xsd:string ;
    chebi:inchi "InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1"^^xsd:string ;
    chebi:inchikey "CZMRCDWAGMRECN-UGDNZRGBSA-N"^^xsd:string ;
    chebi:mass "342.29650"^^xsd:string ;
    chebi:monoisotopicmass "342.11621"^^xsd:string ;
    chebi:smiles "OC[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:15128"^^xsd:string, "CHEBI:26812"^^xsd:string, "CHEBI:45795"^^xsd:string, "CHEBI:9314"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:90825"^^xsd:string, "CAS:57-50-1"^^xsd:string, "DrugBank:DB02772"^^xsd:string, "Drug_Central:4610"^^xsd:string, "Gmelin:97695"^^xsd:string, "HMDB:HMDB0000258"^^xsd:string, "KEGG:C00089"^^xsd:string, "KEGG:D00025"^^xsd:string, "KEGG:D06533"^^xsd:string, "KEGG:G00370"^^xsd:string, "KNApSAcK:C00001151"^^xsd:string, "MetaCyc:SUCROSE"^^xsd:string, "PDBeChem:SUC"^^xsd:string, "PMID:11021636"^^xsd:string, "PMID:11093712"^^xsd:string, "PMID:11111003"^^xsd:string, "PMID:12065720"^^xsd:string, "PMID:12706980"^^xsd:string, "PMID:13508893"^^xsd:string, "PMID:15291457"^^xsd:string, "PMID:15660210"^^xsd:string, "PMID:15792978"^^xsd:string, "PMID:15845855"^^xsd:string, "PMID:16228482"^^xsd:string, "PMID:16304615"^^xsd:string, "PMID:16313996"^^xsd:string, "PMID:16525719"^^xsd:string, "PMID:16660545"^^xsd:string, "PMID:16663947"^^xsd:string, "PMID:16665852"^^xsd:string, "PMID:17233733"^^xsd:string, "PMID:17439666"^^xsd:string, "PMID:17597061"^^xsd:string, "PMID:18625236"^^xsd:string, "PMID:19199566"^^xsd:string, "PMID:19726178"^^xsd:string, "PMID:21703290"^^xsd:string, "PMID:21972845"^^xsd:string, "PMID:22085755"^^xsd:string, "PMID:22311778"^^xsd:string, "PMID:22404833"^^xsd:string, "PMID:22751876"^^xsd:string, "Reaxys:1435311"^^xsd:string, "Reaxys:90825"^^xsd:string, "Wikipedia:Sucrose"^^xsd:string ;
    oboInOwl:hasExactSynonym "SUCROSE"^^xsd:string, "Sucrose"^^xsd:string, "beta-D-fructofuranosyl alpha-D-glucopyranoside"^^xsd:string, "sucrose"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "1-alpha-D-Glucopyranosyl-2-beta-D-fructofuranoside"^^xsd:string, "Cane sugar"^^xsd:string, "Saccharose"^^xsd:string, "Sacharose"^^xsd:string, "White sugar"^^xsd:string, "beta-D-Fruf-(2<->1)-alpha-D-Glcp"^^xsd:string, "sacarosa"^^xsd:string, "table sugar"^^xsd:string ;
    oboInOwl:id "CHEBI:17992"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "sucrose"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_23367
    obo:IAO_0000111 "molecular entity"^^xsd:string ;
    obo:IAO_0000115 "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity."^^xsd:string ;
    obo:IAO_0000116 "We are assuming that every molecular entity has to be completely connected by chemical bonds. This excludes protein complexes, which are comprised of minimally two separate molecular entities. We will follow up with Chebi to ensure this is their understanding as well"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    oboInOwl:hasExactSynonym "molecular entity"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "entidad molecular"^^xsd:string, "entidades moleculares"^^xsd:string, "entite moleculaire"^^xsd:string, "molecular entities"^^xsd:string, "molekulare Entitaet"^^xsd:string ;
    oboInOwl:id "CHEBI:23367"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "molecular entity"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000040, obo:CHEBI_24431 .

obo:CHEBI_24431
    obo:IAO_0000115 "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    oboInOwl:hasExactSynonym "chemical entity"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:id "CHEBI:24431"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "chemical entity"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:CHEBI_26710
    obo:IAO_0000111 "sodium chloride"^^xsd:string ;
    obo:IAO_0000115 "An inorganic chloride salt having sodium(1+) as the counterion."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "sodium chloride"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_2877
    obo:IAO_0000115 "A dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C14H18N2O5"^^xsd:string ;
    chebi:inchi "InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1"^^xsd:string ;
    chebi:inchikey "IAOZJIPTCAWIRG-QWRGUYRKSA-N"^^xsd:string ;
    chebi:mass "294.304"^^xsd:string ;
    chebi:monoisotopicmass "294.12157"^^xsd:string ;
    chebi:smiles "C(C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C(=O)OC)=O)N)(=O)O"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:45047"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:2223850"^^xsd:string, "CAS:22839-47-0"^^xsd:string, "DrugBank:DB00168"^^xsd:string, "HMDB:HMDB0001894"^^xsd:string, "KEGG:C11045"^^xsd:string, "KEGG:D02381"^^xsd:string, "MetaCyc:CPD-5583"^^xsd:string, "PDBeChem:PME"^^xsd:string, "PMID:1771173"^^xsd:string, "PMID:2013754"^^xsd:string, "PMID:21150094"^^xsd:string, "PMID:21372000"^^xsd:string, "PMID:22354473"^^xsd:string, "PMID:24355796"^^xsd:string, "PMID:24925367"^^xsd:string, "PMID:24944748"^^xsd:string, "PMID:24965331"^^xsd:string, "PMID:25431414"^^xsd:string, "PMID:25543075"^^xsd:string, "PMID:25786106"^^xsd:string, "PMID:25951455"^^xsd:string, "PMID:25991916"^^xsd:string, "PMID:26015492"^^xsd:string, "PMID:26099025"^^xsd:string, "PMID:26159964"^^xsd:string, "PMID:26247507"^^xsd:string, "PMID:26308194"^^xsd:string, "PMID:26321723"^^xsd:string, "PMID:26377607"^^xsd:string, "PMID:26582819"^^xsd:string, "PMID:26593524"^^xsd:string, "PMID:26912665"^^xsd:string, "PMID:27015640"^^xsd:string, "PMID:27038223"^^xsd:string, "PMID:27088715"^^xsd:string, "PMID:27127997"^^xsd:string, "PMID:27216413"^^xsd:string, "PMID:27298583"^^xsd:string, "PMID:27492574"^^xsd:string, "PMID:27565676"^^xsd:string, "PMID:27614095"^^xsd:string, "PMID:27640132"^^xsd:string, "PMID:27699780"^^xsd:string, "PMID:27728881"^^xsd:string, "PMID:27840415"^^xsd:string, "PMID:27845306"^^xsd:string, "Patent:US3492131"^^xsd:string, "Reaxys:2223850"^^xsd:string, "Wikipedia:Aspartame"^^xsd:string ;
    oboInOwl:hasExactSynonym "Aspartame"^^xsd:string, "methyl L-alpha-aspartyl-L-phenylalaninate"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "1-methyl N-L-alpha-aspartyl-L-phenylalanate"^^xsd:string, "3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester"^^xsd:string, "3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid"^^xsd:string, "AminoSweet"^^xsd:string, "Asp-phe-ome"^^xsd:string, "Aspartylphenylalanine methyl ester"^^xsd:string, "E 951"^^xsd:string, "L-Aspartyl-L-phenylalanine methyl ester"^^xsd:string, "NutraSweet"^^xsd:string, "Sanecta"^^xsd:string, "aspartam"^^xsd:string, "aspartamo"^^xsd:string, "aspartamum"^^xsd:string ;
    oboInOwl:id "CHEBI:2877"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "aspartame"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_16670, obo:CHEBI_23367 .

obo:CHEBI_30911
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C6H14O6"^^xsd:string ;
    chebi:mass "182.172"^^xsd:string ;
    chebi:monoisotopicmass "182.07904"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:15093"^^xsd:string, "CHEBI:26724"^^xsd:string, "CHEBI:26726"^^xsd:string, "CHEBI:33795"^^xsd:string, "CHEBI:33796"^^xsd:string, "CHEBI:9201"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:1721909"^^xsd:string, "Gmelin:83165"^^xsd:string, "Wikipedia:Sorbitol"^^xsd:string ;
    oboInOwl:hasExactSynonym "glucitol"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Sorbitol"^^xsd:string, "gulitol"^^xsd:string, "rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol"^^xsd:string ;
    oboInOwl:id "CHEBI:30911"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "glucitol"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_32111
    obo:IAO_0000115 "A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C7H5NO3S"^^xsd:string ;
    chebi:inchi "InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)"^^xsd:string ;
    chebi:inchikey "CVHZOJJKTDOEJC-UHFFFAOYSA-N"^^xsd:string ;
    chebi:mass "183.18500"^^xsd:string ;
    chebi:monoisotopicmass "182.99901"^^xsd:string ;
    chebi:smiles "O=C1NS(=O)(=O)c2ccccc12"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:49717"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:6888"^^xsd:string, "CAS:81-07-2"^^xsd:string, "Gmelin:4203"^^xsd:string, "HMDB:HMDB0029723"^^xsd:string, "KEGG:D01085"^^xsd:string, "MetaCyc:CPD-5581"^^xsd:string, "PDBeChem:LSA"^^xsd:string, "PMID:24456165"^^xsd:string, "PMID:24549104"^^xsd:string, "PMID:24739358"^^xsd:string, "PMID:24780866"^^xsd:string, "Reaxys:6888"^^xsd:string, "Wikipedia:Saccharin"^^xsd:string ;
    oboInOwl:hasExactSynonym "1,2-benzisothiazol-3(2H)-one 1,1-dioxide"^^xsd:string, "Saccharin"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "1,1-Dioxo-1,2-benzisothiazol-3(2H)-one"^^xsd:string, "1,1-Dioxo-1,2-dihydro-benzo[d]isothiazol-3-one"^^xsd:string, "1,2-Benzisothiazol-3(2H)-one 1,1-dioxide"^^xsd:string, "1,2-Benzisothiazolin-3-one 1,1-dioxide"^^xsd:string, "1,2-Dihydro-2-ketobenzisosulfonazole"^^xsd:string, "1,2-Dihydro-2-ketobenzisosulphonazole"^^xsd:string, "2,3-Dihydro-3-oxobenzisosulfonazole"^^xsd:string, "2,3-Dihydro-3-oxobenzisosulphonazole"^^xsd:string, "3-Hydroxybenzisothiazole-S,S-dioxide"^^xsd:string, "Anhydro-o-sulfaminebenzoic acid"^^xsd:string, "Benzo-2-sulphimide"^^xsd:string, "Benzoic acid sulfimide"^^xsd:string, "Benzoic sulfimide"^^xsd:string, "Benzoic sulphimide"^^xsd:string, "Benzosulfimide"^^xsd:string, "Benzosulphimide"^^xsd:string, "Benzoylsulfonic Imide"^^xsd:string, "Saccharimide"^^xsd:string, "Saccharine"^^xsd:string, "o-Benzoic sulfimide"^^xsd:string, "o-Benzosulfimide"^^xsd:string, "o-Sulfobenzimide"^^xsd:string, "o-Sulfobenzoic acid imide"^^xsd:string ;
    oboInOwl:id "CHEBI:32111"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:comment "Saccharin is an artificial sweetener. The basic substance, benzoic sulfilimine, has effectively no food energy and is much sweeter than sucrose, but has a bitter or metallic aftertaste, especially at high concentrations. It is used to sweeten products such as drinks, candies, cookies, medicines, and toothpaste. (wikipedia)" ;
    rdfs:label "saccharin"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_33130
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "AlH3O3"^^xsd:string, "H3AlO3"^^xsd:string ;
    chebi:inchi "InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3"^^xsd:string ;
    chebi:inchikey "WNROFYMDJYEPJX-UHFFFAOYSA-K"^^xsd:string ;
    chebi:mass "78.00356"^^xsd:string ;
    chebi:monoisotopicmass "77.98976"^^xsd:string ;
    chebi:smiles "[H]O[Al](O[H])O[H]"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:30193"^^xsd:string, "CHEBI:31195"^^xsd:string ;
    oboInOwl:hasDbXref "CAS:21645-51-2"^^xsd:string, "Drug_Central:4250"^^xsd:string, "Gmelin:22216"^^xsd:string, "KEGG:C13391"^^xsd:string, "KEGG:D02859"^^xsd:string, "Wikipedia:Aluminum_Hydroxide"^^xsd:string ;
    oboInOwl:hasExactSynonym "aluminium(3+) hydroxide"^^xsd:string, "aluminium(III) hydroxide"^^xsd:string, "trihydroxidoaluminium"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Al(OH)3"^^xsd:string, "Aluminiumhydroxid"^^xsd:string, "Aluminum hydroxide"^^xsd:string ;
    oboInOwl:id "CHEBI:33130"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "aluminium hydroxide"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_37586
    obo:IAO_0000111 "sodium phosphate"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "sodium phosphate"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_52071
    obo:IAO_0000115 "A (1->6)-alpha-D-glucan which has extra branching consisting of (1->2), (1->3) or (1->4) linkages."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    oboInOwl:hasDbXref "CAS:9004-54-0"^^xsd:string, "KEGG:C00372"^^xsd:string, "KEGG:D00060"^^xsd:string, "KEGG:D06541"^^xsd:string, "KEGG:G10502"^^xsd:string, "PMID:8154046"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "(1,6-alpha-D-Glucosyl)m"^^xsd:string, "(1,6-alpha-D-Glucosyl)m+1"^^xsd:string, "(1,6-alpha-D-Glucosyl)n"^^xsd:string, "(1,6-alpha-D-Glucosyl)n+1"^^xsd:string, "1,6-alpha-D-Glucan"^^xsd:string, "Dextran 40"^^xsd:string, "Dextran 70"^^xsd:string, "Dextran 75"^^xsd:string, "dextran"^^xsd:string, "dextrane"^^xsd:string, "dextrano"^^xsd:string, "dextrans"^^xsd:string, "dextranum"^^xsd:string ;
    oboInOwl:id "CHEBI:52071"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "dextran"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_53424
    obo:IAO_0000115 "A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C58H114O26"^^xsd:string ;
    chebi:mass "1226.75977"^^xsd:string ;
    chebi:monoisotopicmass "1226.760"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:8973037"^^xsd:string, "CAS:9005-64-5"^^xsd:string, "KEGG:C11624"^^xsd:string, "KEGG:D05565"^^xsd:string, "Reaxys:8187252"^^xsd:string, "Reaxys:8973037"^^xsd:string, "Wikipedia:Polysorbate_20"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Polyoxyethylene (20) sorbitan monolaurate"^^xsd:string, "Polyoxyethylene sorbitan monolaurate"^^xsd:string, "Polysorbate"^^xsd:string, "Polysorbate 20"^^xsd:string, "Tween 20"^^xsd:string, "polisorbato"^^xsd:string, "polysorbate"^^xsd:string, "polysorbatum"^^xsd:string ;
    oboInOwl:id "CHEBI:53424"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "polysorbate 20"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_53426
    obo:IAO_0000115 "A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C64H124O26"^^xsd:string ;
    chebi:mass "1308.83802"^^xsd:string ;
    chebi:monoisotopicmass "1308.838"^^xsd:string ;
    oboInOwl:hasAlternativeId "CHEBI:9785"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:8187125"^^xsd:string, "CAS:9005-65-6"^^xsd:string, "KEGG:C11625"^^xsd:string, "KEGG:D01067"^^xsd:string, "Reaxys:8187125"^^xsd:string, "Reaxys:8190601"^^xsd:string, "Reaxys:8898414"^^xsd:string, "Reaxys:9040798"^^xsd:string, "Wikipedia:Polysorbate_80"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Glycol (polysorbate 80)"^^xsd:string, "Polyethylene oxide sorbitan mono-oleate"^^xsd:string, "Polyoxyethylene (20) sorbitan monooleate"^^xsd:string, "Polyoxyethylene sorbitan monooleate"^^xsd:string, "Polyoxyethylene sorbitan oleate"^^xsd:string, "Polysorbate 80"^^xsd:string, "Tween 80"^^xsd:string, "polisorbato"^^xsd:string, "polysorbate"^^xsd:string, "polysorbatum"^^xsd:string ;
    oboInOwl:id "CHEBI:53426"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:comment "Polysorbate 80 (brand names include Alkest, Canarcel and Tween, which is a registered trademark of ICI Americas, Inc.) is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid, and is often used in foods. Polysorbate 80 is a viscous, water-soluble yellow liquid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups which are polymers of ethylene oxide. In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case the oleic acid (see polysorbate for more detail). Polysorbate 80 is often used in food and other products as an emulsifier. (wikipedia)" ;
    rdfs:label "polysorbate 80"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_64220
    obo:IAO_0000115 "An organic sodium salt that is the monosodium salt of glutamic acid."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C5H8NNaO4"^^xsd:string ;
    chebi:inchi "InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1"^^xsd:string ;
    chebi:inchikey "LPUQAYUQRXPFSQ-UHFFFAOYSA-M"^^xsd:string ;
    chebi:mass "169.11110"^^xsd:string ;
    chebi:monoisotopicmass "169.03510"^^xsd:string ;
    chebi:smiles "[Na+].[NH3+]C(CCC([O-])=O)C([O-])=O"^^xsd:string ;
    oboInOwl:hasDbXref "PMID:22293291"^^xsd:string, "Reaxys:17003240"^^xsd:string ;
    oboInOwl:hasExactSynonym "sodium 2-azaniumylpentanedioate"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "MSG"^^xsd:string, "sodium 2-ammoniopentanedioate"^^xsd:string, "sodium glutamate"^^xsd:string ;
    oboInOwl:id "CHEBI:64220"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "monosodium glutamate"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_7507
    obo:IAO_0000115 "A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    oboInOwl:hasDbXref "CAS:1404-04-2"^^xsd:string, "DrugBank:DB00994"^^xsd:string, "KEGG:C00384"^^xsd:string, "KEGG:D08260"^^xsd:string ;
    oboInOwl:hasExactSynonym "Neomycin"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:id "CHEBI:7507"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "neomycin"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CHEBI_9546
    obo:IAO_0000115 "An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/chebi.owl> ;
    chebi:charge "0"^^xsd:string ;
    chebi:formula "C9H9HgNaO2S"^^xsd:string, "C9H9HgO2S.Na"^^xsd:string ;
    chebi:inchi "InChI=1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2"^^xsd:string ;
    chebi:inchikey "RTKIYNMVFMVABJ-UHFFFAOYSA-L"^^xsd:string ;
    chebi:mass "404.81233"^^xsd:string ;
    chebi:monoisotopicmass "405.99274"^^xsd:string ;
    chebi:smiles "[Na+].CC[Hg]Sc1ccccc1C([O-])=O"^^xsd:string ;
    oboInOwl:hasDbXref "Beilstein:8169555"^^xsd:string, "CAS:54-64-8"^^xsd:string, "Gmelin:1677155"^^xsd:string, "KEGG:D00864"^^xsd:string, "PMID:18837732"^^xsd:string, "PMID:21616561"^^xsd:string, "PMID:21785120"^^xsd:string, "PMID:22015977"^^xsd:string, "PMID:22366633"^^xsd:string, "PMID:22658806"^^xsd:string, "PMID:22811707"^^xsd:string, "PMID:23145070"^^xsd:string, "PMID:23223227"^^xsd:string, "PMID:23282150"^^xsd:string, "PMID:23401210"^^xsd:string, "PMID:23554557"^^xsd:string, "PMID:23843785"^^xsd:string, "PMID:23949514"^^xsd:string, "PMID:23965928"^^xsd:string, "PMID:23992327"^^xsd:string, "PMID:25042713"^^xsd:string, "PPDB:3062"^^xsd:string, "Reaxys:8169555"^^xsd:string, "VSDB:3062"^^xsd:string ;
    oboInOwl:hasExactSynonym "Thimerosal"^^xsd:string, "sodium [(2-carboxylatophenyl)sulfanyl](ethyl)mercurate(1-)"^^xsd:string, "sodium ethyl[2-(sulfanyl-kappaS)benzoato(2-)]mercurate(1-)"^^xsd:string ;
    oboInOwl:hasOBONamespace "chebi_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Merthiolate"^^xsd:string, "Thiomersal"^^xsd:string, "[(o-carboxyphenyl)thio]ethylmercury sodium salt"^^xsd:string, "ethyl(2-mercaptobenzoato-S)mercury sodium salt"^^xsd:string, "ethylmercurithiosalicylate sodium"^^xsd:string, "ethylmercurithiosalicylic acid sodium salt"^^xsd:string, "mercurothiolate"^^xsd:string, "o-(ethylmercurithio)benzoic acid sodium salt"^^xsd:string, "sodium ethylmercurithiosalicylate"^^xsd:string, "sodium merthiolate"^^xsd:string, "thiomersal"^^xsd:string, "thiomersalate"^^xsd:string, "thiomersalum"^^xsd:string, "tiomersal"^^xsd:string ;
    oboInOwl:id "CHEBI:9546"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR> ;
    a owl:Class ;
    rdfs:label "thimerosal"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:CL_0000000
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/cl.owl> .

obo:CL_0000540
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/cl.owl> .

obo:DOID_0050117
    obo:IAO_0000115 "A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:10115"^^xsd:string, "DOID:11078"^^xsd:string, "DOID:1304"^^xsd:string, "DOID:1321"^^xsd:string, "DOID:2040"^^xsd:string, "DOID:2288"^^xsd:string, "DOID:3099"^^xsd:string, "DOID:4120"^^xsd:string, "DOID:4620"^^xsd:string, "DOID:5256"^^xsd:string, "DOID:945"^^xsd:string, "DOID:95"^^xsd:string, "DOID:9532"^^xsd:string, "DOID:9696"^^xsd:string ;
    oboInOwl:hasDbXref "ICD9CM:079.0"^^xsd:string, "UMLS_CUI:C0001485"^^xsd:string ;
    oboInOwl:hasExactSynonym "infectious disease"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:0050117"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#NCIthesaurus> ;
    a owl:Class ;
    rdfs:label "disease by infectious agent"^^xsd:string ;
    rdfs:subClassOf obo:DOID_4 .

obo:DOID_0050338
    obo:IAO_0000115 "A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:0050338"^^xsd:string ;
    a owl:Class ;
    rdfs:label "primary bacterial infectious disease"^^xsd:string ;
    rdfs:subClassOf obo:DOID_104 .

obo:DOID_0050687
    obo:IAO_0000115 "A cancer that is classified by the type of cell from which it is derived."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:created_by "snadendla"^^xsd:string ;
    oboInOwl:creation_date "2011-06-13T03:28:50Z"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:0050687"^^xsd:string ;
    a owl:Class ;
    rdfs:label "cell type cancer"^^xsd:string ;
    rdfs:subClassOf obo:DOID_162 .

obo:DOID_104
    obo:IAO_0000115 "A disease by infectious agent that results_in infection, has_material_basis_in Bacteria."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "ICD10CM:A49"^^xsd:string, "ICD10CM:A49.9"^^xsd:string, "MSH:D001424"^^xsd:string, "NCI:C2890"^^xsd:string, "SNOMEDCT_US_2015_03_01:154318005"^^xsd:string, "SNOMEDCT_US_2015_03_01:186470002"^^xsd:string, "SNOMEDCT_US_2015_03_01:187347000"^^xsd:string, "SNOMEDCT_US_2015_03_01:266182006"^^xsd:string, "SNOMEDCT_US_2015_03_01:266187000"^^xsd:string, "SNOMEDCT_US_2015_03_01:301811001"^^xsd:string, "SNOMEDCT_US_2015_03_01:87628006"^^xsd:string, "UMLS_CUI:C0004623"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:104"^^xsd:string ;
    a owl:Class ;
    rdfs:label "bacterial infectious disease"^^xsd:string ;
    rdfs:subClassOf obo:DOID_0050117 .

obo:DOID_11076
    obo:IAO_0000115 "A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:11076"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease>, <http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease> ;
    a owl:Class ;
    rdfs:label "Brucella suis brucellosis"^^xsd:string ;
    rdfs:subClassOf obo:DOID_11077 .

obo:DOID_11077
    obo:IAO_0000115 "A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:0050060"^^xsd:string ;
    oboInOwl:hasDbXref "ICD10CM:A23"^^xsd:string, "ICD10CM:A23.9"^^xsd:string, "ICD9CM:023"^^xsd:string, "ICD9CM:023.9"^^xsd:string, "MSH:D002006"^^xsd:string, "NCI:C84602"^^xsd:string, "SNOMEDCT_US_2015_03_01:111804008"^^xsd:string, "SNOMEDCT_US_2015_03_01:154296006"^^xsd:string, "SNOMEDCT_US_2015_03_01:186310006"^^xsd:string, "SNOMEDCT_US_2015_03_01:187304000"^^xsd:string, "SNOMEDCT_US_2015_03_01:75702008"^^xsd:string, "UMLS_CUI:C0006309"^^xsd:string ;
    oboInOwl:hasExactSynonym "Maltese fever"^^xsd:string, "undulant fever"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bang's disease"^^xsd:string, "Gibraltar fever"^^xsd:string, "Malta fever"^^xsd:string, "Mediterranean fever"^^xsd:string ;
    oboInOwl:id "DOID:11077"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease>, <http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease> ;
    a owl:Class ;
    rdfs:label "brucellosis"^^xsd:string ;
    rdfs:subClassOf obo:DOID_0050338 .

obo:DOID_12365
    obo:IAO_0000115 "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:12552"^^xsd:string ;
    oboInOwl:hasDbXref "EFO:0001068"^^xsd:string, "ICD10CM:B54"^^xsd:string, "ICD9CM:084"^^xsd:string, "ICD9CM:084.6"^^xsd:string, "MSH:D008288"^^xsd:string, "NCI:C34797"^^xsd:string, "OMIM:609148"^^xsd:string, "SNOMEDCT_US_2015_03_01:105649009"^^xsd:string, "SNOMEDCT_US_2015_03_01:154374002"^^xsd:string, "SNOMEDCT_US_2015_03_01:186797008"^^xsd:string, "SNOMEDCT_US_2015_03_01:187510004"^^xsd:string, "SNOMEDCT_US_2015_03_01:248437004"^^xsd:string, "SNOMEDCT_US_2015_03_01:61462000"^^xsd:string, "UMLS_CUI:C0024530"^^xsd:string ;
    oboInOwl:hasExactSynonym "induced malaria"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:12365"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#DO_MGI_slim> ;
    a owl:Class ;
    rdfs:comment "Xref MGI."^^xsd:string ;
    rdfs:label "malaria"^^xsd:string ;
    rdfs:subClassOf obo:DOID_2789 .

obo:DOID_1398
    obo:IAO_0000115 "A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:11681"^^xsd:string, "DOID:13509"^^xsd:string, "DOID:1396"^^xsd:string, "DOID:1494"^^xsd:string, "DOID:2114"^^xsd:string, "DOID:2293"^^xsd:string, "DOID:2922"^^xsd:string, "DOID:3564"^^xsd:string, "DOID:4191"^^xsd:string, "DOID:886"^^xsd:string, "DOID:948"^^xsd:string, "DOID:9639"^^xsd:string, "DOID:9644"^^xsd:string ;
    oboInOwl:hasDbXref "ICD10CM:H44.12"^^xsd:string, "ICD9CM:360.13"^^xsd:string, "NCI:C34587"^^xsd:string, "SNOMEDCT_US_2015_03_01:193273005"^^xsd:string, "SNOMEDCT_US_2015_03_01:57100005"^^xsd:string, "UMLS_CUI:C0014238"^^xsd:string ;
    oboInOwl:hasExactSynonym "Ectoparasitic disease"^^xsd:string, "parasitemia"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:1398"^^xsd:string ;
    a owl:Class ;
    rdfs:label "parasitic infectious disease"^^xsd:string ;
    rdfs:subClassOf obo:DOID_0050117 .

obo:DOID_14067
    obo:IAO_0000115 "A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "ICD10CM:B50"^^xsd:string, "ICD10CM:B50.9"^^xsd:string, "ICD9CM:084.0"^^xsd:string, "MSH:D016778"^^xsd:string, "NCI:C34798"^^xsd:string, "SNOMEDCT_US_2015_03_01:186802002"^^xsd:string, "SNOMEDCT_US_2015_03_01:187504004"^^xsd:string, "SNOMEDCT_US_2015_03_01:248441000"^^xsd:string, "SNOMEDCT_US_2015_03_01:62676009"^^xsd:string, "UMLS_CUI:C0024535"^^xsd:string ;
    oboInOwl:hasExactSynonym "Falciparum Malaria"^^xsd:string, "Falciparum malaria (disorder)"^^xsd:string, "Falciparum malaria [malignant tertian]"^^xsd:string, "Malaria fever, subtertian"^^xsd:string, "Plasmodium falciparum malaria, unspecified"^^xsd:string, "Plasmodium falciparum malaria, unspecified (disorder)"^^xsd:string, "malignant tertian fever (finding)"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:14067"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Plasmodium falciparum malaria"^^xsd:string ;
    rdfs:subClassOf obo:DOID_12365 .

obo:DOID_14456
    obo:IAO_0000115 "A brucellosis that involves an infection caused by Brucella melitensis [NCBITaxon:29459] in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "ICD10CM:A23.0"^^xsd:string, "ICD9CM:023.0"^^xsd:string, "SNOMEDCT_US_2015_03_01:186305007"^^xsd:string, "SNOMEDCT_US_2015_03_01:30789005"^^xsd:string, "SNOMEDCT_US_2015_03_01:427999003"^^xsd:string, "UMLS_CUI:C0302362"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:14456"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease>, <http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease> ;
    a owl:Class ;
    rdfs:label "Brucella melitensis brucellosis"^^xsd:string ;
    rdfs:subClassOf obo:DOID_11077 .

obo:DOID_14457
    obo:IAO_0000115 "A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "ICD10CM:A23.1"^^xsd:string, "ICD9CM:023.1"^^xsd:string, "MSH:D002007"^^xsd:string, "SNOMEDCT_US_2015_03_01:186306008"^^xsd:string, "SNOMEDCT_US_2015_03_01:427795000"^^xsd:string, "SNOMEDCT_US_2015_03_01:9060000"^^xsd:string, "UMLS_CUI:C0302363"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:14457"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease>, <http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease> ;
    a owl:Class ;
    rdfs:label "Brucella abortus brucellosis"^^xsd:string ;
    rdfs:subClassOf obo:DOID_11077 .

obo:DOID_14566
    obo:IAO_0000115 "A disease that is characterized by abnormally rapid cell division."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:0000818"^^xsd:string ;
    oboInOwl:hasExactSynonym "cell process disease"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:14566"^^xsd:string ;
    a owl:Class ;
    rdfs:label "disease of cellular proliferation"^^xsd:string ;
    rdfs:subClassOf obo:DOID_4 .

obo:DOID_162
    obo:IAO_0000115 "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "ICD10CM:C80"^^xsd:string, "ICD10CM:C80.1"^^xsd:string, "ICD9CM:199"^^xsd:string, "MSH:D009369"^^xsd:string, "NCI:C9305"^^xsd:string, "SNOMEDCT_US_2015_03_01:154432008"^^xsd:string, "SNOMEDCT_US_2015_03_01:154433003"^^xsd:string, "SNOMEDCT_US_2015_03_01:154577008"^^xsd:string, "SNOMEDCT_US_2015_03_01:187597000"^^xsd:string, "SNOMEDCT_US_2015_03_01:188475001"^^xsd:string, "SNOMEDCT_US_2015_03_01:188482002"^^xsd:string, "SNOMEDCT_US_2015_03_01:190150006"^^xsd:string, "SNOMEDCT_US_2015_03_01:269513004"^^xsd:string, "SNOMEDCT_US_2015_03_01:269623003"^^xsd:string, "SNOMEDCT_US_2015_03_01:269626006"^^xsd:string, "SNOMEDCT_US_2015_03_01:269634000"^^xsd:string, "SNOMEDCT_US_2015_03_01:363346000"^^xsd:string, "SNOMEDCT_US_2015_03_01:38807002"^^xsd:string, "UMLS_CUI:C0006826"^^xsd:string ;
    oboInOwl:hasExactSynonym "malignant neoplasm"^^xsd:string, "malignant tumor "^^xsd:string, "primary cancer"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:162"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Updating out dated UMLS CUI."^^xsd:string ;
    rdfs:label "cancer"^^xsd:string ;
    rdfs:subClassOf obo:DOID_14566 .

obo:DOID_1909
    obo:IAO_0000115 "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "EFO:0000756"^^xsd:string, "KEGG:05218"^^xsd:string, "MSH:D008545"^^xsd:string, "NCI:C3224"^^xsd:string, "OMIM:155600"^^xsd:string, "SNOMEDCT_US_2015_03_01:154501005"^^xsd:string, "SNOMEDCT_US_2015_03_01:189749008"^^xsd:string, "SNOMEDCT_US_2015_03_01:2092003"^^xsd:string, "SNOMEDCT_US_2015_03_01:269503007"^^xsd:string, "SNOMEDCT_US_2015_03_01:269577007"^^xsd:string, "SNOMEDCT_US_2015_03_01:372244006"^^xsd:string, "UMLS_CUI:C0025202"^^xsd:string ;
    oboInOwl:hasExactSynonym "Naevocarcinoma"^^xsd:string, "malignant melanoma"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:1909"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim> ;
    a owl:Class ;
    rdfs:label "melanoma"^^xsd:string ;
    rdfs:subClassOf obo:DOID_0050687 .

obo:DOID_2789
    obo:IAO_0000115 "A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:0060003"^^xsd:string, "DOID:10553"^^xsd:string, "DOID:3734"^^xsd:string, "DOID:3804"^^xsd:string, "DOID:947"^^xsd:string ;
    oboInOwl:hasDbXref "ICD10CM:B50-B64"^^xsd:string, "ICD10CM:B64"^^xsd:string, "MSH:D011528"^^xsd:string, "NCI:C34953"^^xsd:string, "SNOMEDCT_US_2015_03_01:187247003"^^xsd:string, "SNOMEDCT_US_2015_03_01:187502000"^^xsd:string, "SNOMEDCT_US_2015_03_01:187517001"^^xsd:string, "SNOMEDCT_US_2015_03_01:240627001"^^xsd:string, "SNOMEDCT_US_2015_03_01:367372008"^^xsd:string, "SNOMEDCT_US_2015_03_01:89933001"^^xsd:string, "SNOMEDCT_US_2015_03_01:95896000"^^xsd:string, "UMLS_CUI:C0033740"^^xsd:string ;
    oboInOwl:hasExactSynonym "mastigophora infectious disease"^^xsd:string, "sarcomastigophora infectious disease"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:2789"^^xsd:string ;
    a owl:Class ;
    rdfs:label "parasitic protozoa infectious disease"^^xsd:string ;
    rdfs:subClassOf obo:DOID_1398 .

obo:DOID_2905
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease> .

obo:DOID_4
    obo:IAO_0000115 "A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "MSH:D004194"^^xsd:string, "NCI:C2991"^^xsd:string, "SNOMEDCT_US_2015_03_01:64572001"^^xsd:string, "UMLS_CUI:C0012634"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:4"^^xsd:string ;
    a owl:Class ;
    rdfs:label "disease"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000016 .

obo:DOID_526
    obo:IAO_0000115 "A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasDbXref "ICD10CM:B20"^^xsd:string, "ICD10CM:B20-B20"^^xsd:string, "ICD9CM:042"^^xsd:string, "ICD9CM:042-042.99"^^xsd:string, "MSH:D015658"^^xsd:string, "NCI:C3108"^^xsd:string, "SNOMEDCT_US_2015_03_01:123321001"^^xsd:string, "SNOMEDCT_US_2015_03_01:186705005"^^xsd:string, "SNOMEDCT_US_2015_03_01:187438009"^^xsd:string, "SNOMEDCT_US_2015_03_01:187453001"^^xsd:string, "SNOMEDCT_US_2015_03_01:86406008"^^xsd:string, "UMLS_CUI:C0019693"^^xsd:string ;
    oboInOwl:hasExactSynonym "HIV infection"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:526"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease> ;
    a owl:Class ;
    rdfs:label "Human immunodeficiency virus infectious disease"^^xsd:string ;
    rdfs:subClassOf obo:DOID_934 .

obo:DOID_8469
    obo:IAO_0000115 "A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:8468"^^xsd:string ;
    oboInOwl:hasDbXref "ICD10CM:J11.1"^^xsd:string, "ICD9CM:487"^^xsd:string, "MSH:D007251"^^xsd:string, "NCI:C53482"^^xsd:string, "SNOMEDCT_US_2015_03_01:155559006"^^xsd:string, "SNOMEDCT_US_2015_03_01:155562009"^^xsd:string, "SNOMEDCT_US_2015_03_01:195931008"^^xsd:string, "SNOMEDCT_US_2015_03_01:266353003"^^xsd:string, "SNOMEDCT_US_2015_03_01:266393000"^^xsd:string, "SNOMEDCT_US_2015_03_01:6142004"^^xsd:string, "UMLS_CUI:C0021400"^^xsd:string ;
    oboInOwl:hasExactSynonym "Influenza with non-respiratory manifestation (disorder)"^^xsd:string, "Influenza with other manifestations"^^xsd:string, "Influenza with other manifestations (disorder)"^^xsd:string, "Influenza with other manifestations NOS (disorder)"^^xsd:string, "flu"^^xsd:string, "influenza with non-respiratory manifestation"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:id "DOID:8469"^^xsd:string ;
    a owl:Class ;
    rdfs:label "influenza" ;
    rdfs:subClassOf obo:DOID_934 .

obo:DOID_934
    obo:IAO_0000115 "A disease by infectious agent that results_in infection, has_material_basis_in Viruses."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/doid.owl> ;
    oboInOwl:hasAlternativeId "DOID:1329"^^xsd:string ;
    oboInOwl:hasDbXref "ICD10CM:A94"^^xsd:string, "ICD10CM:B34"^^xsd:string, "ICD10CM:B34.9"^^xsd:string, "ICD9CM:060-066.99"^^xsd:string, "ICD9CM:066.9"^^xsd:string, "MSH:D001102"^^xsd:string, "MSH:D014777"^^xsd:string, "NCI:C3439"^^xsd:string, "NCI:C34396"^^xsd:string, "SNOMEDCT_US_2015_03_01:154319002"^^xsd:string, "SNOMEDCT_US_2015_03_01:154345006"^^xsd:string, "SNOMEDCT_US_2015_03_01:154372003"^^xsd:string, "SNOMEDCT_US_2015_03_01:186619002"^^xsd:string, "SNOMEDCT_US_2015_03_01:186754003"^^xsd:string, "SNOMEDCT_US_2015_03_01:187471008"^^xsd:string, "SNOMEDCT_US_2015_03_01:266116004"^^xsd:string, "SNOMEDCT_US_2015_03_01:266188005"^^xsd:string, "SNOMEDCT_US_2015_03_01:266194002"^^xsd:string, "SNOMEDCT_US_2015_03_01:34014006"^^xsd:string, "SNOMEDCT_US_2015_03_01:40610006"^^xsd:string, "UMLS_CUI:C0003723"^^xsd:string, "UMLS_CUI:C0042769"^^xsd:string ;
    oboInOwl:hasExactSynonym "Viral Infection"^^xsd:string, "Viral disease"^^xsd:string, "Viral disease (disorder)"^^xsd:string, "Viral infection NOS"^^xsd:string, "Viral infection NOS (disorder)"^^xsd:string, "Viral infection, unspecified (disorder)"^^xsd:string, "Viral: [infection NOS] or [illness]"^^xsd:string, "arbovirus infectious disease"^^xsd:string, "virus infection"^^xsd:string ;
    oboInOwl:hasOBONamespace "disease_ontology"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "arthropod-borne viruses"^^xsd:string ;
    oboInOwl:id "DOID:934"^^xsd:string ;
    a owl:Class ;
    rdfs:label "viral infectious disease"^^xsd:string ;
    rdfs:subClassOf obo:DOID_0050117 .

obo:ENVO_0002036
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/envo.owl> .

obo:FMA_12278
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/fma.owl> ;
    oboInOwl:hasOBONamespace "fma"^^xsd:string ;
    oboInOwl:id "FMA:12278"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Hormone"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:GO_0002250
    obo:IAO_0000115 "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:hasDbXref "Wikipedia:Adaptive_immune_system"^^xsd:string ;
    oboInOwl:hasExactSynonym "acquired immune response"^^xsd:string ;
    oboInOwl:hasOBONamespace "biological_process"^^xsd:string ;
    oboInOwl:id "GO:0002250"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "This term was added by GO_REF:0000022."^^xsd:string ;
    rdfs:label "adaptive immune response"^^xsd:string ;
    rdfs:subClassOf obo:GO_0006955 .

obo:GO_0002385
    obo:IAO_0000115 "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> ;
    oboInOwl:hasOBONamespace "biological_process"^^xsd:string ;
    oboInOwl:id "GO:0002385"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "This term was added by GO_REF:0000022."^^xsd:string ;
    rdfs:label "mucosal immune response"^^xsd:string ;
    rdfs:subClassOf obo:GO_0006955 .

obo:GO_0006955
    obo:IAO_0000111 "immune response"^^xsd:string ;
    obo:IAO_0000115 "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:hasOBONamespace "biological_process"^^xsd:string ;
    oboInOwl:id "GO:0006955"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "This term was improved by GO_REF:0000022. It was redefined and moved."^^xsd:string ;
    rdfs:label "immune response"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000015, obo:GO_0050896 .

obo:GO_0008150
    obo:IAO_0000111 "biological_process"^^xsd:string ;
    obo:IAO_0000115 "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "biological_process"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:GO_0016020
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0019814
    obo:IAO_0000115 "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:hasOBONamespace "cellular_component"^^xsd:string ;
    oboInOwl:id "GO:0019814"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/go#goslim_pir> ;
    a owl:Class ;
    rdfs:comment "Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available."^^xsd:string ;
    rdfs:label "immunoglobulin complex"^^xsd:string ;
    rdfs:subClassOf obo:GO_0043234 .

obo:GO_0030424
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0030425
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0042734
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0042995
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0043005
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0043234
    obo:IAO_0000115 "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:hasDbXref "Wikipedia:Protein_complex"^^xsd:string ;
    oboInOwl:hasExactSynonym "protein-protein complex"^^xsd:string ;
    oboInOwl:hasOBONamespace "cellular_component"^^xsd:string ;
    oboInOwl:id "GO:0043234"^^xsd:string ;
    oboInOwl:inSubset <http://purl.obolibrary.org/obo/go#goslim_chembl>, <http://purl.obolibrary.org/obo/go#goslim_generic>, <http://purl.obolibrary.org/obo/go#goslim_pir>, <http://purl.obolibrary.org/obo/go#gosubset_prok> ;
    a owl:Class ;
    rdfs:comment "A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole."^^xsd:string ;
    rdfs:label "protein complex"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:GO_0044456
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0044464
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0045202
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0045211
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl> .

obo:GO_0050896
    obo:IAO_0000111 "response to stimulus"^^xsd:string ;
    obo:IAO_0000115 "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "response to stimulus"^^xsd:string ;
    rdfs:subClassOf obo:GO_0008150 .

obo:GO_0071735
    obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:created_by "midori"^^xsd:string ;
    oboInOwl:creation_date "2010-03-24T01:44:53Z"^^xsd:string ;
    oboInOwl:hasNarrowSynonym "IgG1"^^xsd:string, "IgG2"^^xsd:string, "IgG2a"^^xsd:string, "IgG2b"^^xsd:string, "IgG2c"^^xsd:string, "IgG3"^^xsd:string, "IgG4"^^xsd:string ;
    oboInOwl:hasOBONamespace "cellular_component"^^xsd:string ;
    oboInOwl:id "GO:0071735"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species."^^xsd:string ;
    rdfs:label "IgG immunoglobulin complex"^^xsd:string ;
    rdfs:subClassOf obo:GO_0019814 .

obo:GO_0071738
    obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:created_by "midori"^^xsd:string ;
    oboInOwl:creation_date "2010-03-24T01:44:53Z"^^xsd:string ;
    oboInOwl:hasOBONamespace "cellular_component"^^xsd:string ;
    oboInOwl:id "GO:0071738"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available."^^xsd:string ;
    rdfs:label "IgD immunoglobulin complex"^^xsd:string ;
    rdfs:subClassOf obo:GO_0019814 .

obo:GO_0071742
    obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:created_by "midori"^^xsd:string ;
    oboInOwl:creation_date "2010-03-24T01:44:53Z"^^xsd:string ;
    oboInOwl:hasOBONamespace "cellular_component"^^xsd:string ;
    oboInOwl:id "GO:0071742"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available."^^xsd:string ;
    rdfs:label "IgE immunoglobulin complex"^^xsd:string ;
    rdfs:subClassOf obo:GO_0019814 .

obo:GO_0071745
    obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:created_by "midori"^^xsd:string ;
    oboInOwl:creation_date "2010-03-24T01:44:53Z"^^xsd:string ;
    oboInOwl:hasNarrowSynonym "IgA1 antibody"^^xsd:string, "IgA2 antibody"^^xsd:string ;
    oboInOwl:hasOBONamespace "cellular_component"^^xsd:string ;
    oboInOwl:id "GO:0071745"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available."^^xsd:string ;
    rdfs:label "IgA immunoglobulin complex"^^xsd:string ;
    rdfs:subClassOf obo:GO_0019814 .

obo:GO_0071753
    obo:IAO_0000115 "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/go.owl>, <http://purl.org/obo/owl/molecular_function> ;
    oboInOwl:created_by "midori"^^xsd:string ;
    oboInOwl:creation_date "2010-03-24T01:44:53Z"^^xsd:string ;
    oboInOwl:hasOBONamespace "cellular_component"^^xsd:string ;
    oboInOwl:id "GO:0071753"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available."^^xsd:string ;
    rdfs:label "IgM immunoglobulin complex"^^xsd:string ;
    rdfs:subClassOf obo:GO_0019814 .

obo:IAO_0000001
    obo:IAO_0000111 "conditional specification"@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "a directive information entity that specifies what should happen if the trigger condition is fulfilled"@en ;
    obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ;
    obo:IAO_0000119 "OBI branch derived"@en, "OBI_0000349"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "conditional specification"@en ;
    rdfs:subClassOf obo:IAO_0000033 .

obo:IAO_0000002
    obo:IAO_0000111 "example to be eventually removed"@en ;
    a obo:IAO_0000078, owl:NamedIndividual ;
    rdfs:label "example to be eventually removed"@en .

obo:IAO_0000003
    obo:IAO_0000111 "measurement unit label"@en ;
    obo:IAO_0000112 "Examples of measurement unit labels are liters, inches, weight per volume."@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure."@en ;
    obo:IAO_0000116 """2009-03-16: provenance: a term measurement unit was
proposed for OBI (OBI_0000176) , edited by Chris Stoeckert and
Cristian Cocos, and subsequently moved to IAO where the objective for
which the original term was defined was satisfied with the definition
of this, different, term."""@en, "2009-03-16: review of this term done during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI."@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "measurement unit label"@en ;
    rdfs:subClassOf obo:IAO_0000009 .

obo:IAO_0000005
    obo:IAO_0000111 "objective specification"@en ;
    obo:IAO_0000112 "In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction."@en ;
    obo:IAO_0000114 obo:IAO_0000122, obo:IAO_0000125 ;
    obo:IAO_0000115 "A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved."@en ;
    obo:IAO_0000116 "2009-03-16: original definition when imported from OBI read: \"objective is an non realizable information entity which can serve as that  proper part of a plan towards which the realization of the plan is directed.\""@en, "2014-03-31: In the example of usage (\"In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction\") there is a protocol which is the ChIP assay protocol. In addition to being concretized on paper, the protocol can be concretized as a realizable entity, such as a plan that inheres in a person. The objective specification is the part that says that some protein and DNA interactions are identified. This is a specification of a process endpoint: the boundary in the process before which they are not identified and after which they are. During the realization of the plan, the goal is to get to the point of having the interactions, and participants in the realization of the plan try to do that."@en, "Answers the question, why did you do this experiment?"@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Barry Smith"@en, "PERSON: Bjoern Peters"@en, "PERSON: Jennifer Fostel"@en ;
    obo:IAO_0000118 "goal specification"@en ;
    obo:IAO_0000119 "OBI Plan and Planned Process/Roles Branch"@en, "OBI_0000217"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "objective specification"@en ;
    rdfs:subClassOf obo:IAO_0000033 .

obo:IAO_0000007
    obo:IAO_0000112 "Pour the contents of flask 1 into flask 2"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A directive information entity that describes an action the bearer will take."@en ;
    obo:IAO_0000117 "Alan Ruttenberg"@en ;
    obo:IAO_0000119 "OBI Plan and Planned Process branch"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "action specification"@en ;
    rdfs:subClassOf obo:IAO_0000033 .

obo:IAO_0000009
    obo:IAO_0000111 "datum label"@en ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "A label is a symbol that is part of some other datum and is used to either partially define  the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label"@en ;
    obo:IAO_0000116 "http://www.golovchenko.org/cgi-bin/wnsearch?q=label#4n"@en ;
    obo:IAO_0000117 "GROUP: IAO"@en ;
    obo:IAO_0000232 """9/22/11 BP: changed the rdfs:label for this class from 'label' to 'datum label' to convey that this class is not intended to cover all kinds of labels (stickers, radiolabels, etc.), and not even all kind of textual labels, but rather the kind of labels occuring in a datum. 
""" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "datum label"@en ;
    rdfs:subClassOf obo:IAO_0000030 .

obo:IAO_0000013
    obo:IAO_0000111 "journal article"@en ;
    obo:IAO_0000112 "Examples are articles published in the journals, Nature and Science. The content can often be cited by reference to a paper based encoding, e.g.  Authors, Title of article, Journal name, date or year of publication, volume and page number."@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "a report that is published in a journal"@en ;
    obo:IAO_0000117 "person:Alan Ruttenberg"@en, "person:Chris Stoeckert"@en ;
    obo:IAO_0000119 "OBI_0000159"@en, "group:OBI"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "journal article"@en ;
    rdfs:subClassOf obo:IAO_0000088, [
        a owl:Restriction ;
        owl:onProperty obo:IAO_0000142 ;
        owl:someValuesFrom obo:VO_0000001
    ] .

obo:IAO_0000027
    obo:IAO_0000111 "data item"@en ;
    obo:IAO_0000112 "Data items include counts of things, analyte concentrations, and statistical summaries."@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en, "a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en ;
    obo:IAO_0000116 "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers."@en, "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum."@en, "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym."@en, "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/", """JAR: datum     -- well, this will be very tricky to define, but maybe some 
information-like stuff that might be put into a computer and that is 
meant, by someone, to denote and/or to be interpreted by some 
process... I would include lists, tables, sentences... I think I might 
defer to Barry, or to Brian Cantwell Smith

JAR: A data item is an approximately justified approximately true approximate belief"""@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Chris Stoeckert"@en, "PERSON: Jonathan Rees"@en ;
    obo:IAO_0000118 "data"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "data item"@en ;
    rdfs:subClassOf obo:IAO_0000030 .

obo:IAO_0000030
    obo:IAO_0000111 "information content entity"@en ;
    obo:IAO_0000112 "Examples of information content entites include journal articles, data, graphical layouts, and graphs."@en ;
    obo:IAO_0000114 obo:IAO_0000122, obo:IAO_0000125 ;
    obo:IAO_0000115 "A generically dependent continuant that is about some thing."@en ;
    obo:IAO_0000116 "2014-03-10: The use of \"thing\" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)."@en, """information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907).

Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity."""@en ;
    obo:IAO_0000117 "PERSON: Chris Stoeckert"@en ;
    obo:IAO_0000119 "OBI_0000142"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "information content entity"@en ;
    rdfs:subClassOf obo:BFO_0000031, [
        a owl:Restriction ;
        owl:onProperty obo:IAO_0000136 ;
        owl:someValuesFrom obo:BFO_0000001
    ] .

obo:IAO_0000032
    obo:IAO_0000112 "10 feet. 3 ml."@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label."@en ;
    obo:IAO_0000116 """2009-03-16: we decided to keep datum singular in scalar measurement datum, as in
this case we explicitly refer to the singular form"""@en, "Would write this as: has_part some 'measurement unit label' and has_part some numeral and has_part exactly 2, except for the fact that this won't let us take advantage of OWL reasoning over the numbers. Instead use has measurment value property to represent the same. Use has measurement unit label (subproperty of has_part) so we can easily say that there is only one of them."@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "scalar measurement datum"@en ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:IAO_0000033
    obo:IAO_0000114 obo:IAO_0000122, obo:IAO_0000123 ;
    obo:IAO_0000115 "An information content entity whose concretizations indicate to their bearer how to realize them in a process."@en ;
    obo:IAO_0000116 "2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was  \"is the specification of a process that can be concretized and realized by an actor\" with alternative term  \"instruction\".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term."@en, "2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it."@en, "8/6/2009 Alan Ruttenberg: Changed label from \"information entity about a realizable\" after discussions at ICBO"@en, "Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan"@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bjoern Peters"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "directive information entity"@en ;
    rdfs:subClassOf obo:IAO_0000030, [
        a owl:Restriction ;
        owl:onProperty obo:IAO_0000136 ;
        owl:someValuesFrom obo:BFO_0000017
    ] .

obo:IAO_0000064
    obo:IAO_0000111 "algorithm"@en ;
    obo:IAO_0000112 "PMID: 18378114.Genomics. 2008 Mar 28. LINKGEN: A new algorithm to process data in genetic linkage studies."@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata."@en ;
    obo:IAO_0000117 "Philippe Rocca-Serra"@en, "PlanAndPlannedProcess Branch"@en ;
    obo:IAO_0000119 "OBI_0000270"@en, "adapted from discussion on OBI list (Matthew Pocock, Christian Cocos, Alan Ruttenberg)"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "algorithm"@en ;
    rdfs:subClassOf obo:IAO_0000104 .

obo:IAO_0000078
    obo:IAO_0000111 "curation status specification"@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en ;
    obo:IAO_0000116 "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)"@en ;
    obo:IAO_0000117 "PERSON:Bill Bug"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en, "OBI_0000266"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "curation status specification"@en ;
    rdfs:subClassOf obo:IAO_0000102 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:oneOf (obo:IAO_0000002
            obo:IAO_0000120
            obo:IAO_0000121
            obo:IAO_0000122
            obo:IAO_0000123
            obo:IAO_0000124
            obo:IAO_0000125
            obo:IAO_0000423
            obo:IAO_0000428
        )
    ] .

obo:IAO_0000088
    obo:IAO_0000111 "report"@en ;
    obo:IAO_0000112 "Examples of reports are gene lists and investigation reports. These are not published (journal) articles but may be included in a journal article."@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "a document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record)"@en ;
    obo:IAO_0000116 """2009-03-16: comment from Darren Natale: I am slightly uneasy with the sentence \"Topic of the report is on 
something that has completed.\"  Should it be restricted to those things 
that are completed?  For example, a progress report is (usually) about 
something that definitely has *not* been completed, or may include 
(only) projections.  I think the definition would not suffer if the 
whole sentence is deleted."""@en, "2009-03-16: this was report of results with definition: A report is a narrative object that is a formal statement of the results of an investigation, or of any matter on which definite information is required, made by some person or body instructed or required to do so."@en, "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI."@en, "2009-08-10 Alan Ruttenberg: Larry Hunter suggests that this be obsoleted and replaced by 'document'. Alan restored as there are OBI dependencies and this merits further discussion"@en, "disagreement about where reports go. alan: only some gene lists are reports. Is a report all the content of some document? The example of usage suggests that a report may be part of  some article. Term needs clarification"@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Melanie Courtot"@en, "PERSON:Chris Stoeckert"@en ;
    obo:IAO_0000119 "GROUP: OBI"@en, "OBI_0000099"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "report"@en ;
    rdfs:subClassOf obo:IAO_0000310 .

obo:IAO_0000100
    obo:IAO_0000111 "data set"@en ;
    obo:IAO_0000112 "Intensity values in a CEL file or from multiple CEL files comprise a data set (as opposed to the CEL files themselves)."@en ;
    obo:IAO_0000114 obo:IAO_0000120, obo:IAO_0000125 ;
    obo:IAO_0000115 "A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets."@en ;
    obo:IAO_0000116 "2009/10/23 Alan Ruttenberg. The intention is that this term represent collections of like data. So this isn't for, e.g. the whole contents of a cel file, which includes parameters, metadata etc. This is more like java arrays of a certain rather specific type"@en, "2014-05-05: Data sets are aggregates and thus must include two or more data items. We have chosen not to add logical axioms to make this restriction." ;
    obo:IAO_0000117 "person:Allyson Lister"@en, "person:Chris Stoeckert"@en ;
    obo:IAO_0000119 "OBI_0000042"@en, "group:OBI"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "data set"@en ;
    rdfs:subClassOf obo:IAO_0000027 .

obo:IAO_0000102
    obo:IAO_0000111 "data about an ontology part"@en ;
    obo:IAO_0000115 "Data about an ontology part is a data item about a part of an ontology, for example a term"@en ;
    obo:IAO_0000117 "Person:Alan Ruttenberg"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "data about an ontology part"@en ;
    rdfs:subClassOf obo:IAO_0000027 .

obo:IAO_0000104
    obo:IAO_0000111 "plan specification"@en ;
    obo:IAO_0000112 "PMID: 18323827.Nat Med. 2008 Mar;14(3):226.New plan proposed to help resolve conflicting medical advice."@en ;
    obo:IAO_0000114 obo:IAO_0000120, obo:IAO_0000122 ;
    obo:IAO_0000115 "A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified."@en ;
    obo:IAO_0000116 "2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was \" a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan\". It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term."@en, "2014-03-31: A plan specification can have other parts, such as conditional specifications."@en, "Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved"@en ;
    obo:IAO_0000117 "Alan Ruttenberg"@en ;
    obo:IAO_0000119 "OBI Plan and Planned Process branch"@en, "OBI_0000344"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:comment """2/3/2009 Comment from OBI review.

Action specification not well enough specified.
Conditional specification not well enough specified.
Question whether all plan specifications have objective specifications.

Request that IAO either clarify these or change definitions not to use them"""@en ;
    rdfs:label "plan specification"@en ;
    rdfs:subClassOf obo:IAO_0000033, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:IAO_0000005
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:IAO_0000007
    ] .

obo:IAO_0000109
    obo:IAO_0000111 "measurement datum"@en ;
    obo:IAO_0000112 "Examples of measurement data are the recoding of the weight of a mouse as {40,mass,\"grams\"}, the recording of an observation of the behavior of the mouse {,process,\"agitated\"}, the recording of the expression level of a gene as measured through the process of microarray experiment {3.4,luminosity,}."@en ;
    obo:IAO_0000114 obo:IAO_0000120, obo:IAO_0000125 ;
    obo:IAO_0000115 "A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device."@en ;
    obo:IAO_0000116 "2/2/2009 is_specified_output of some assay?"@en ;
    obo:IAO_0000117 "person:Chris Stoeckert"@en ;
    obo:IAO_0000119 "OBI_0000305"@en, "group:OBI"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "measurement datum"@en ;
    rdfs:subClassOf obo:IAO_0000027, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0001938 ;
        owl:someValuesFrom obo:OBI_0001933
    ] .

obo:IAO_0000111
    obo:IAO_0000111 "editor preferred label", "editor preferred label"@en, "editor preferred term", "editor preferred term"@en, "editor preferred term~editor preferred label" ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)"@en ;
    obo:IAO_0000117 "PERSON:Daniel Schober"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "editor preferred label", "editor preferred label"@en, "editor preferred term", "editor preferred term"@en, "editor preferred term~editor preferred label" .

obo:IAO_0000112
    obo:IAO_0000111 "example"@en, "example of usage"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not"@en, "A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold."@en ;
    obo:IAO_0000117 "PERSON:Daniel Schober"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "example of usage", "example of usage"@en .

obo:IAO_0000113
    obo:IAO_0000111 "in branch"@en ;
    obo:IAO_0000115 "An annotation property indicating which module the terms belong to. This is currently experimental and not implemented yet."@en ;
    obo:IAO_0000117 "GROUP:OBI"@en ;
    obo:IAO_0000119 "OBI_0000277"@en ;
    a owl:AnnotationProperty ;
    rdfs:label "in branch", "in branch"@en .

obo:IAO_0000114
    obo:IAO_0000111 "has curation status"@en ;
    obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Bill Bug"@en, "PERSON:Melanie Courtot"@en ;
    obo:IAO_0000119 "OBI_0000281"@en ;
    a owl:AnnotationProperty ;
    rdfs:label "has curation status", "has curation status"@en .

obo:IAO_0000115
    obo:IAO_0000111 "definition"^^xsd:string, "definition"@en, "textual definition"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en, "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en ;
    obo:IAO_0000116 """2012-04-05: 
Barry Smith

The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions'  is terrible.

Can you fix to something like:

A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.

Alan Ruttenberg

Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. 

On the specifics of the proposed definition:

We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. 

Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. 

We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.  """@en ;
    obo:IAO_0000117 "PERSON:Daniel Schober"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "definition"^^xsd:string, "definition"@en, "textual definition"^^xsd:string .

obo:IAO_0000116
    obo:IAO_0000111 "editor note"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en ;
    obo:IAO_0000117 "PERSON:Daniel Schober"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obfoundry.org/obo/obi>"@en, "GROUP:OBI:<http://purl.obofoundry.org/obo/obi>"@en ;
    oboInOwl:hasDbXref "IAO:0000116"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "editor_note"^^xsd:string ;
    oboInOwl:is_metadata_tag 1, true ;
    oboInOwl:shorthand "editor_note"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "editor note", "editor note"@en .

obo:IAO_0000117
    obo:IAO_0000111 "definition editor"@en, "term editor"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en, "Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people"@en ;
    obo:IAO_0000116 "20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115."@en, "20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115."@en ;
    obo:IAO_0000117 "PERSON:Daniel Schober"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "definition editor", "definition editor"@en, "term editor", "term editor"@en .

obo:IAO_0000118
    obo:IAO_0000111 "alternative term"@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)"@en ;
    obo:IAO_0000117 "PERSON:Daniel Schober"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "alternative term", "alternative term"@en .

obo:IAO_0000119
    obo:IAO_0000111 "definition source"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en, "formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007"@en ;
    obo:IAO_0000117 "PERSON:Daniel Schober"@en ;
    obo:IAO_0000119 "Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w"^^xsd:string, "Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w"@en, "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "definition source", "definition source"@en .

obo:IAO_0000120
    obo:IAO_0000111 "metadata complete"@en ;
    obo:IAO_0000115 "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en ;
    a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ;
    rdfs:label "metadata complete"@en .

obo:IAO_0000121
    obo:IAO_0000111 "organizational term"@en ;
    obo:IAO_0000115 "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en ;
    obo:IAO_0000117 "PERSON:Alan Ruttenberg"^^xsd:string ;
    a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ;
    rdfs:label "organizational term"@en .

obo:IAO_0000122
    obo:IAO_0000111 "ready for release"@en ;
    obo:IAO_0000115 "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release.  Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""@en ;
    a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ;
    rdfs:label "ready for release"@en .

obo:IAO_0000123
    obo:IAO_0000111 "metadata incomplete"@en ;
    obo:IAO_0000115 "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en ;
    a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ;
    rdfs:label "metadata incomplete"@en .

obo:IAO_0000124
    obo:IAO_0000111 "uncurated"@en ;
    obo:IAO_0000115 "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en ;
    a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ;
    rdfs:label "uncurated"@en .

obo:IAO_0000125
    obo:IAO_0000111 "pending final vetting"@en ;
    obo:IAO_0000115 "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en ;
    a obo:IAO_0000078, owl:NamedIndividual, owl:Thing ;
    rdfs:label "pending final vetting"@en .

obo:IAO_0000136
    obo:IAO_0000112 "This document is about information artifacts and their representations"@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "A (currently) primitive relation that relates an information artifact to an entity."@en, "is_about is a (currently) primitive relation that relates an information artifact to an entity."@en ;
    obo:IAO_0000116 """7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. 

We will try to build it back up by elaborating the various subproperties that are more precisely defined.

Some currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic."""@en ;
    obo:IAO_0000117 "person:Alan Ruttenberg"@en ;
    obo:IAO_0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:IAO_0000030 ;
    rdfs:label "is about"@en .

obo:IAO_0000142
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "An information artifact IA mentions an entity E exactly when it has a component/part that denotes E"@en ;
    obo:IAO_0000116 "7/6/2009 Alan Ruttenberg. P4 RC1 munges our GCI so remove it for now: mentions some entity equivalentTo has_part some ('generically denotes' some entity)"@en, "7/6/2009 Alan Ruttenberg: Add this relation following conversation with Jonathan Rees that N&S GCI for is_about was too strong. Really it was simply sufficient. To effect this change we introduce this relation, which is subproperty of is_about, and have previous GCI use this relation \"mentions\" in it's (logical) definition"@en ;
    obo:IAO_0000117 "PERSON: Jonathan Rees"@en, "Person: Alan Ruttenberg"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "mentions"@en ;
    rdfs:subPropertyOf obo:IAO_0000136 .

obo:IAO_0000225
    obo:IAO_0000114 obo:IAO_0000125 .

obo:IAO_0000231
    a owl:AnnotationProperty ;
    rdfs:label "has obsolescence reason" .

obo:IAO_0000232
    obo:IAO_0000111 "curator note"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An administrative note of use for a curator but of no use for a user"@en ;
    obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en ;
    oboInOwl:hasDbXref "IAO:0000232"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "curator_notes"^^xsd:string ;
    oboInOwl:is_metadata_tag 1, true ;
    oboInOwl:shorthand "curator_notes"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "curator note", "curator note"@en, "curator notes" .

obo:IAO_0000310
    obo:IAO_0000111 "document"@en ;
    obo:IAO_0000112 "A journal article, patent application, laboratory notebook, or a book"@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "A collection of information content entities intended to be understood together as a whole"@en ;
    obo:IAO_0000117 "PERSON: Lawrence Hunter"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/iao.owl> ;
    a owl:Class ;
    rdfs:label "document"@en ;
    rdfs:subClassOf obo:IAO_0000030 .

obo:IAO_0000412
    obo:IAO_0000111 "imported from"@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "For external terms/classes, the ontology from which the term was imported"@en ;
    obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Melanie Courtot"@en ;
    obo:IAO_0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "imported from", "imported from"@en .

obo:IAO_0000423
    obo:IAO_0000111 "to be replaced with external ontology term"@en ;
    obo:IAO_0000115 "Terms with this status should eventually replaced with a term from another ontology."@en ;
    obo:IAO_0000117 "Alan Ruttenberg"@en ;
    obo:IAO_0000119 "group:OBI"@en ;
    a obo:IAO_0000078, owl:NamedIndividual ;
    rdfs:label "to be replaced with external ontology term"@en .

obo:IAO_0000424
    a owl:AnnotationProperty ;
    rdfs:label "expand expression to", "expand expression to"@en .

obo:IAO_0000428
    obo:IAO_0000111 "requires discussion"@en ;
    obo:IAO_0000115 "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en ;
    obo:IAO_0000117 "Alan Ruttenberg"@en ;
    obo:IAO_0000119 "group:OBI"@en ;
    a obo:IAO_0000078, owl:NamedIndividual ;
    rdfs:label "requires discussion"@en .

obo:IAO_0000589
    obo:IAO_0000111 "OBO foundry unique label"@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "An alternative name for a class or property which is unique across the OBO Foundry."@en ;
    obo:IAO_0000116 "The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools ."@en ;
    obo:IAO_0000117 "PERSON:Alan Ruttenberg"@en, "PERSON:Bjoern Peters"@en, "PERSON:Chris Mungall"@en, "PERSON:Melanie Courtot"@en ;
    obo:IAO_0000119 "GROUP:OBO Foundry <http://obofoundry.org/>"@en ;
    a owl:AnnotationProperty ;
    rdfs:label "OBO foundry unique label", "OBO foundry unique label"@en .

obo:IAO_0000600
    obo:IAO_0000111 "elucidation"@en ;
    obo:IAO_0000117 "person:Alan Ruttenberg"@en ;
    obo:IAO_0000119 "Person:Barry Smith"@en ;
    obo:IAO_0000600 "Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "elucidation", "elucidation"@en .

obo:IAO_0000601
    obo:IAO_0000111 "has associated axiom(nl)"@en ;
    obo:IAO_0000117 "Person:Alan Ruttenberg"@en ;
    obo:IAO_0000119 "Person:Alan Ruttenberg"@en ;
    obo:IAO_0000600 "An axiom associated with a term expressed using natural language"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "has associated axiom(nl)", "has associated axiom(nl)"@en .

obo:IAO_0000602
    obo:IAO_0000111 "has associated axiom(fol)"@en ;
    obo:IAO_0000117 "Person:Alan Ruttenberg"@en ;
    obo:IAO_0000119 "Person:Alan Ruttenberg"@en ;
    obo:IAO_0000600 "An axiom expressed in first order logic using CLIF syntax"@en ;
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "has associated axiom(fol)", "has associated axiom(fol)"@en .

obo:IAO_0010000
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.obolibrary.org/obo/iao.owl> ;
    rdfs:label "has axiom label" .

obo:IAO_0100001
    obo:IAO_0000114 obo:IAO_0000125 .

obo:IDO_0000528
    obo:IAO_0000111 "pathogen"@en ;
    obo:IAO_0000115 "A material entity with a pathogenic disposition."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ido.owl> ;
    a owl:Class ;
    rdfs:label "pathogen"@en ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:IDO_0000547
    obo:IAO_0000111 "virulence factor"@en ;
    obo:IAO_0000115 "A biological macromolecule produced by a pathogen and that has a virulence factor disposition."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ido.owl> ;
    a owl:Class ;
    rdfs:label "virulence factor"@en ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:NCBITaxon_10090
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:85055"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "house mouse"^^xsd:string, "mouse"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mus musculus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_39107 .

obo:NCBITaxon_10114
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "rat"^^xsd:string, "rats"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rattus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_39107 .

obo:NCBITaxon_10141
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:84274"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "domestic guinea pig"^^xsd:string, "guinea pig"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Cavia aperea porcellus"^^xsd:string, "Cavia cobaya"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Cavia porcellus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33550 .

obo:NCBITaxon_10150
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "chinchillas"^^xsd:string, "chinchillas and viscachas"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chinchillidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33550 .

obo:NCBITaxon_10239
    obo:IAO_0000111 "Viruses"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superkingdom ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Vira"^^xsd:string, "Viridae"^^xsd:string, "viruses"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Viruses"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0100026 .

obo:NCBITaxon_10240
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Poxviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732525 .

obo:NCBITaxon_10241
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chordopoxvirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10240 .

obo:NCBITaxon_10242
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthopoxvirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10241 .

obo:NCBITaxon_10244
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "monkey pox virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Monkeypox virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10242 .

obo:NCBITaxon_10245
    a owl:Class ;
    rdfs:label "Vaccinia virus" ;
    rdfs:subClassOf obo:NCBITaxon_10242 .

obo:NCBITaxon_10255
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12871"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "small pox virus"^^xsd:string, "smallpox"^^xsd:string, "smallpox virus"^^xsd:string, "variola virus VAR"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Variola virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10242 .

obo:NCBITaxon_10258
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Contagious pustular dermatitis virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orf virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10241 .

obo:NCBITaxon_10260
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Avipoxvirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10241 .

obo:NCBITaxon_10261
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "FWPV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avipoxvirus clade A1"^^xsd:string, "Fowlpoxvirus"^^xsd:string, "fowl poxvirus"^^xsd:string, "fowlpox virus FP"^^xsd:string, "fowlpox virus FPV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Fowlpox virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10260 .

obo:NCBITaxon_10264
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Pigeon pox virus"^^xsd:string, "Pigeon poxvirus"^^xsd:string, "pigeonpox virus PPV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pigeonpox virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10260 .

obo:NCBITaxon_102793
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "H5N1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "H5N1 subtype"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11320 .

obo:NCBITaxon_10292
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Herpesviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10239 .

obo:NCBITaxon_10293
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Alphaherpesviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Alphaherpesvirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10292 .

obo:NCBITaxon_10294
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Simplexvirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10293 .

obo:NCBITaxon_10298
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HSV-1"^^xsd:string, "HSV1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Herpes simplex virus type 1"^^xsd:string, "Human herpesvirus type 1"^^xsd:string, "herpes simplex virus 1 HSV-1"^^xsd:string, "herpes simplex virus HSV-1"^^xsd:string, "herpes simplex virus type 1 HSV-1"^^xsd:string, "herpes simplex virus type 1 HSV1"^^xsd:string, "herpes simplex virus type-1 HSV-1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Herpes simplex virus 1"^^xsd:string, "Human herpesvirus 1"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10294 .

obo:NCBITaxon_10310
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HSV2"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Herpes simplex virus (type 2)"^^xsd:string, "Herpes simplex virus II"^^xsd:string, "Herpes simplex virus type 2"^^xsd:string, "Herpes simplex virus type 2 (HSV-2)"^^xsd:string, "Human herpesvirus 2"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Herpes simplex virus 2"^^xsd:string, "herpes simplex virus type 2 HSV-2"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human alphaherpesvirus 2"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10294 .

obo:NCBITaxon_10319
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Varicellovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10293 .

obo:NCBITaxon_10320
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:11265"^^xsd:string, "NCBITaxon:12738"^^xsd:string ;
    oboInOwl:hasBroadSynonym "BoHV-1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bovine herpesvirus 1"^^xsd:string, "Bovine herpesvirus type 1"^^xsd:string, "Bovine herpesvirus-1"^^xsd:string, "Bovine rhinotracheitis virus"^^xsd:string, "bovine herpesvirus 1 BHV 1"^^xsd:string, "bovine herpesvirus 1 BHV-1"^^xsd:string, "bovine herpesvirus 1 BHV1"^^xsd:string, "bovine herpesvirus BHV-1"^^xsd:string, "bovine herpesvirus type 1 BHV-1"^^xsd:string, "bovine herpesvirus type-1 BHV-1"^^xsd:string, "infectious bovine rhinotracheitis virus BHV-1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Infectious bovine rhinotracheitis virus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10319 .

obo:NCBITaxon_10326
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "EHV-1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Equid herpesvirus 1"^^xsd:string, "Equine herpesvirus 1"^^xsd:string, "Equine herpesvirus type 1"^^xsd:string, "Equine herpesvirus-1"^^xsd:string, "equine abortion virus"^^xsd:string, "equine herpesvirus 1 EHV-1"^^xsd:string, "equine herpesvirus type-1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "equine herpesvirus type 1 EHV-1"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Equid alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10319 .

obo:NCBITaxon_10334
    obo:IAO_0000116 "Feline viral rhinotracheitis virus" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Felid herpesvirus 1"^^xsd:string, "Feline alphaherpesvirus 1"^^xsd:string, "Feline herpesvirus 1"^^xsd:string, "Feline herpesvirus type 1"^^xsd:string, "feline herpesvirus"^^xsd:string, "feline herpesvirus type 1 FHV-1"^^xsd:string, "feline herpesvirus-1"^^xsd:string, "feline herpesvirus-1 FHV-1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Felid alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10319 .

obo:NCBITaxon_10335
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HHV-3"^^xsd:string, "VZV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human herpes virus 3"^^xsd:string, "Human herpesvirus 3"^^xsd:string, "Varicella Zoster Virus"^^xsd:string, "Varicella-zoster virus"^^xsd:string, "varicella zoster virus VZV"^^xsd:string, "varicella-zoster virus VZV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human alphaherpesvirus 3"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10319 .

obo:NCBITaxon_10345
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:44156"^^xsd:string ;
    oboInOwl:hasBroadSynonym "PRV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Alphaherpesvirus pseudorabies virus PRV"^^xsd:string, "Aujeszky's disease virus"^^xsd:string, "Pseudorabies Virus PRV"^^xsd:string, "Pseudorabies virus"^^xsd:string, "Suid herpesvirus 1"^^xsd:string, "Suid herpesvirus type 1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Suid alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10319 .

obo:NCBITaxon_10357
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Betaherpesviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Betaherpesvirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10292 .

obo:NCBITaxon_10359
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HHV-5"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human cytomegalovirus"^^xsd:string, "Human herpesvirus 5"^^xsd:string, "human herpesvirus type 5"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human betaherpesvirus 5"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10357 .

obo:NCBITaxon_10366
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Mouse cytomegalovirus 1"^^xsd:string, "Murid herpesvirus 1"^^xsd:string, "Murine cytomegalovirus"^^xsd:string, "murine cytomegalovirus (MCMV)"^^xsd:string, "murine cytomegalovirus MCMV"^^xsd:string, "murine herpesvirus 1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Murid betaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10357 .

obo:NCBITaxon_10386
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:10342"^^xsd:string, "NCBITaxon:12743"^^xsd:string, "NCBITaxon:46620"^^xsd:string ;
    oboInOwl:hasBroadSynonym "GaHV-1"^^xsd:string, "ILTV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avian infectious laryngotracheitis virus"^^xsd:string, "Gallid herpesvirus 1"^^xsd:string, "Gallid herpesvirus type 1"^^xsd:string, "Laryngotracheitis virus"^^xsd:string, "infectious laryngotracheitis virus ILTV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Infectious laryngotracheitis virus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Gallid alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_180255 .

obo:NCBITaxon_10390
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:38013"^^xsd:string, "NCBITaxon:39111"^^xsd:string, "NCBITaxon:43684"^^xsd:string ;
    oboInOwl:hasBroadSynonym "GaHV-2"^^xsd:string, "MDV1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Gallid herpesvirus 2"^^xsd:string, "Gallid herpesvirus type 2"^^xsd:string, "Marek disease virus"^^xsd:string, "Marek disease virus type 1"^^xsd:string, "Marek's disease herpesvirus"^^xsd:string, "Marek's disease herpesvirus 1"^^xsd:string, "Marek's disease virus"^^xsd:string, "Marek's disease virus (MDV)"^^xsd:string, "Marek's disease virus MDV"^^xsd:string, "Marek's disease virus MDV1"^^xsd:string, "Marek's disease virus serotype 1 MDV-1"^^xsd:string, "Marek's disease virus type 1 MDV1"^^xsd:string, "Mareks disease virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Marek's disease virus type 1"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Gallid alphaherpesvirus 2"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_180252 .

obo:NCBITaxon_10405
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "mammalian hepatitis B-type viruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthohepadnavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732514 .

obo:NCBITaxon_10407
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HBV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human hepatitis B virus"^^xsd:string, "hepatitis B virus (HBV)"^^xsd:string, "hepatitis B virus HBV"^^xsd:string, "hepatitis B virus, HBV"^^xsd:string, "human hepatitis B virus HBV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Hepatitis B virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10405 .

obo:NCBITaxon_104388
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:72150"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Anatid Herpes virus-1"^^xsd:string, "Anatid herpesvirus 1"^^xsd:string, "Duck enteritis virus"^^xsd:string, "Duck plague virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Anatid alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_180252 .

obo:NCBITaxon_10469
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Baculovirus"^^xsd:string, "Baculovirus sp."^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "unidentified baculovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10239 .

obo:NCBITaxon_10497
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "ASFV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "African swine fever virus ASF"^^xsd:string, "African swine fever virus ASFV"^^xsd:string, "African swine fever virus, ASFV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "African swine fever virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732525 .

obo:NCBITaxon_10508
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Adenoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732005 .

obo:NCBITaxon_10512
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasAlternativeId "NCBITaxon:12607"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Canine adenovirus type 1"^^xsd:string, "Canine adenovirus type 1 Cav-1"^^xsd:string, "Mastadenovirus c1"^^xsd:string, "Mastadenovirus can1"^^xsd:string, "canine adenovirus type 1 Can1"^^xsd:string, "dog adenovirus 1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine adenovirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10537 .

obo:NCBITaxon_10514
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Canine adenovirus type 2"^^xsd:string, "Canine adenovirus type 2 Cav-1"^^xsd:string, "Mastadenovirus c2"^^xsd:string, "Mastadenovirus can2"^^xsd:string, "dog adenovirus 2"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine adenovirus 2"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10537 .

obo:NCBITaxon_10537
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Canine adenovirus"^^xsd:string, "Canine adenovirus A"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine mastadenovirus A"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10508 .

obo:NCBITaxon_10566
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human Papilloma Virus"^^xsd:string, "human papillomavirus HPV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human papillomavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_333774 .

obo:NCBITaxon_10571
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine papillomavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_333774 .

obo:NCBITaxon_10624
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    a owl:Class .

obo:NCBITaxon_10625
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    a owl:Class .

obo:NCBITaxon_10781
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus .

obo:NCBITaxon_107819
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Clostridium perfringens (type D)"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Clostridium perfringens D"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1502 .

obo:NCBITaxon_10786
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "FPLV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Feline panleucopenia virus"^^xsd:string, "Feline panleukopaenia virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Feline panleukopenia virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1506574 .

obo:NCBITaxon_10787
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Feline panleukopenia virus (strain 193)"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10786 .

obo:NCBITaxon_10788
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasBroadSynonym "CPV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine parvovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10786 .

obo:NCBITaxon_10792
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasBroadSynonym "MEV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mink enteritis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10786 .

obo:NCBITaxon_10796
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "PPV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "porcine parvovirus PPV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Porcine parvovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1506574 .

obo:NCBITaxon_10880
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Reoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732396 .

obo:NCBITaxon_10892
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Orbiviridae"^^xsd:string, "Orbiviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orbivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_689832 .

obo:NCBITaxon_10912
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Rotaviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rotavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_689832 .

obo:NCBITaxon_10913
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Porcine rotavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10912 .

obo:NCBITaxon_10927
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "bovine rotavirus BRV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine rotavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10912 .

obo:NCBITaxon_10937
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Equine rotavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10912 .

obo:NCBITaxon_10993
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Birnaviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732396 .

obo:NCBITaxon_10995
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12740"^^xsd:string ;
    oboInOwl:hasBroadSynonym "IBDV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avian infectious bursal disease virus"^^xsd:string, "Gumboro virus"^^xsd:string, "Infectious bursal disease virus of chickens"^^xsd:string, "infectious bursal disease virus IBDV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Infectious bursal disease virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10993 .

obo:NCBITaxon_11002
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12744"^^xsd:string ;
    oboInOwl:hasBroadSynonym "IPNV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "infectious pancreatic necrosis virus IPNV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Infectious pancreatic necrosis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10993 .

obo:NCBITaxon_11018
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family .

obo:NCBITaxon_11019
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Alphaviridae"^^xsd:string, "arboviruses group A"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Alphavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732461 .

obo:NCBITaxon_11021
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Eastern equine encephalomyelitis virus"^^xsd:string, "eastern equine encephalomyelitis EEE"^^xsd:string, "eastern equine encephalomyelitis virus EEEV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Eastern equine encephalitis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11019 .

obo:NCBITaxon_11034
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Sindbis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11019 .

obo:NCBITaxon_11036
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "VEE"^^xsd:string, "VEEV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Venezuelan equine encephalitis VEE"^^xsd:string, "Venezuelan equine encephalitis virus VEE"^^xsd:string, "Venezuelan equine encephalomyelitis virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasSynonym "VEE virus" ;
    a owl:Class ;
    rdfs:label "Venezuelan equine encephalitis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11019 .

obo:NCBITaxon_11039
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Western equine encephalomyelitis virus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Western equine encephalitis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11019 .

obo:NCBITaxon_11040
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rubivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732461 .

obo:NCBITaxon_11041
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rubella virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11040 .

obo:NCBITaxon_11046
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus .

obo:NCBITaxon_11047
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "EAV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Equine arteritis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_76803 .

obo:NCBITaxon_11050
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Flavivirus (arbovirus group B)"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Flaviviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732406 .

obo:NCBITaxon_11051
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "arboviruses group B"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Flavivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11050 .

obo:NCBITaxon_11071
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subgenus .

obo:NCBITaxon_11072
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Japanese encephalitis (JE) virus"^^xsd:string, "Japanese encephalitis virus JE"^^xsd:string, "Japanese encephalitis virus JEV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11051 .

obo:NCBITaxon_11082
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "WNV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "West Nile virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11051 .

obo:NCBITaxon_11084
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "TBEV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "FSME virus"^^xsd:string, "Tick born encephalitis virus"^^xsd:string, "tick-borne encephalitis virus TBE virus"^^xsd:string, "tick-borne encephalitis virus TBEV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Tick-borne encephalitis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11051 .

obo:NCBITaxon_11089
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "YFV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Flavivirus febricis"^^xsd:string, "yellow fever virus YFV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yellow fever virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11051 .

obo:NCBITaxon_11095
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:12832207"^^xsd:string, "PMID:7747470"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pestivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11050 .

obo:NCBITaxon_11096
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12625"^^xsd:string, "NCBITaxon:54314"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:7747470"^^xsd:string ;
    oboInOwl:hasExactSynonym "Hog cholera virus"^^xsd:string, "Pestivirus type 2"^^xsd:string, "classical swine fever virus CSFV"^^xsd:string, "swine fever virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Classical swine fever virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11095 .

obo:NCBITaxon_11099
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:121864"^^xsd:string ;
    oboInOwl:hasBroadSynonym "BVDV"^^xsd:string, "BVDV-1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:7747470"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bovine viral diarrhea virus"^^xsd:string, "Bovine viral diarrhea virus type 1"^^xsd:string, "Bovine viral diarrhea virus-1"^^xsd:string, "Mucosal disease virus"^^xsd:string, "Pestivirus type 1"^^xsd:string, "bovine viral diarrhea virus BVDV"^^xsd:string, "bovine viral diarrhea virus type I"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine viral diarrhea virus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11095 .

obo:NCBITaxon_111105
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11411686"^^xsd:string, "PMID:28066339"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Porphyromonas gulae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_836 .

obo:NCBITaxon_11118
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Coronaviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_76804 .

obo:NCBITaxon_11120
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasBroadSynonym "IBV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avian infectious bronchitis virus"^^xsd:string, "avian infectious bronchitis coronavirus IBV"^^xsd:string, "avian infectious bronchitis virus IBV"^^xsd:string, "avian infectious bronchitis virus, IBV"^^xsd:string, "infectious bronchitis virus IBV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Infectious bronchitis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2501931 .

obo:NCBITaxon_11128
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasBroadSynonym "BCV"^^xsd:string, "BECV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bovine enteritic coronavirus"^^xsd:string, "Bovine enteritic coronavirus BECV"^^xsd:string, "bovine coronavirus BCV"^^xsd:string, "bovine enteric coronavirus"^^xsd:string, "calf diarrheal coronavirus"^^xsd:string, "neonatal calf diarrhea virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine coronavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_694002 .

obo:NCBITaxon_11135
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasBroadSynonym "FIPV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Feline infectious peritonitis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_693997 .

obo:NCBITaxon_1113537
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_11149
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasAlternativeId "NCBITaxon:12859"^^xsd:string ;
    oboInOwl:hasBroadSynonym "TGEV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Porcine transmissable gastroenteritis coronavirus"^^xsd:string, "Porcine transmissible gastroenteritis coronavirus"^^xsd:string, "porcine transmissible gastroenteritis virus"^^xsd:string, "transmissible gastroenteritis coronavirus"^^xsd:string, "transmissible gastroenteritis virus TGEV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Transmissible gastroenteritis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_693997 .

obo:NCBITaxon_11153
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Canine enteric coronavirus"^^xsd:string, "canine coronavirus CCV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine coronavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_693997 .

obo:NCBITaxon_11157
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "negative-sense genome single-stranded RNA viruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mononegavirales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2497569 .

obo:NCBITaxon_11158
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Paramyxoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11157 .

obo:NCBITaxon_11159
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily .

obo:NCBITaxon_11161
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    a owl:Class .

obo:NCBITaxon_11176
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    a owl:Class .

obo:NCBITaxon_11215
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bovine parainfluenza 3 virus"^^xsd:string, "Bovine parainfluenza virus 3"^^xsd:string, "Bovine parainfluenza virus type 3"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine respirovirus 3"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2560076 .

obo:NCBITaxon_11229
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Morbilliviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Morbillivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2560076 .

obo:NCBITaxon_11232
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "CDV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Canine distemper virus"^^xsd:string, "canine distemper virus CDV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine morbillivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11229 .

obo:NCBITaxon_11234
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:11230"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Cell-associated subacute sclerosing panencephalitis"^^xsd:string, "Measles virus"^^xsd:string, "Subacute sclerosing panencephalitis virus"^^xsd:string, "measles virus MV"^^xsd:string, "rougeole virus"^^xsd:string, "rubeola virus"^^xsd:string, "subacute sclerose panencephalitis virus"^^xsd:string, "subacute sclerosing panencephalitis virus, SSPEV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Measles morbillivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11229 .

obo:NCBITaxon_11241
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "RDV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Rinderpest virus"^^xsd:string, "rinderpest virus RPV"^^xsd:string, "rinderpest virus RV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rinderpest morbillivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11229 .

obo:NCBITaxon_11244
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family, obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Pneumovirinae"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pneumoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11157 .

obo:NCBITaxon_11245
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus .

obo:NCBITaxon_11246
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12604"^^xsd:string ;
    oboInOwl:hasBroadSynonym "BRS"^^xsd:string, "BRSV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bovine respiratory syncytial virus"^^xsd:string, "bovine RSV"^^xsd:string, "bovine respiratory syncytial virus BRSV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine orthopneumovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1868215 .

obo:NCBITaxon_11250
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HRSV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human respiratory syncytial virus"^^xsd:string, "human RSV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human orthopneumovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1868215 .

obo:NCBITaxon_11266
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasAlternativeId "NCBITaxon:11267"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Filovirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Filoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11157 .

obo:NCBITaxon_11270
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:16186241"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rhabdoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11157 .

obo:NCBITaxon_11286
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Lyssavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11270 .

obo:NCBITaxon_11287
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasAlternativeId "NCBITaxon:12873"^^xsd:string, "NCBITaxon:12874"^^xsd:string ;
    oboInOwl:hasBroadSynonym "VHSV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Haemorrhagic septicemia virus"^^xsd:string, "Hemorrhagic septicemia virus"^^xsd:string, "Viral haemorrhagic septicaemia virus"^^xsd:string, "hemorragic septicemy virus of fish"^^xsd:string, "viral haemorrhagic scepticaemia virus VHS"^^xsd:string, "viral haemorrhagic septicaemia virus VHSV"^^xsd:string, "viral hemorrhagic septicemia virus VHSV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Viral hemorrhagic septicemia virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_186778 .

obo:NCBITaxon_11290
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "IHNV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Infectious hematopoietic necrosis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_186778 .

obo:NCBITaxon_11292
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Rabies virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rabies lyssavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11286 .

obo:NCBITaxon_11308
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthomyxoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2497571 .

obo:NCBITaxon_11309
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Influenza virus"^^xsd:string, "Influenza virus sp."^^xsd:string, "Influenzavirus"^^xsd:string, "avian influenza virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "unidentified influenza virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_35324 .

obo:NCBITaxon_11318
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Dhori virus"^^xsd:string, "Tick-borne virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Dhori thogotovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11308 .

obo:NCBITaxon_11320
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "FLUAV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human Influenza A Virus"^^xsd:string, "Influenza virus type A"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Influenza A virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_197911 .

obo:NCBITaxon_114727
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "H1N1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "H1N1 subtype"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11320 .

obo:NCBITaxon_11571
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family .

obo:NCBITaxon_11588
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "RVFV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rift Valley fever virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1980410 .

obo:NCBITaxon_11593
    a owl:Class .

obo:NCBITaxon_11598
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    a owl:Class .

obo:NCBITaxon_11620
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Lassa virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Lassa mammarenavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1653394 .

obo:NCBITaxon_11623
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12748"^^xsd:string ;
    oboInOwl:hasBroadSynonym "LCMV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Lymphocytic choriomeningitis virus"^^xsd:string, "lymphocytic choriomeningitis virus LCMV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Lymphocytic choriomeningitis mammarenavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1653394 .

obo:NCBITaxon_11636
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:11835"^^xsd:string, "NCBITaxon:11872"^^xsd:string, "NCBITaxon:36380"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avian reticuloendotheliosis virus"^^xsd:string, "reticuloendotheliosis virus A REV-A"^^xsd:string, "reticuloendotheliosis virus REV-A"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Reticuloendotheliosis virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_153135 .

obo:NCBITaxon_11646
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Lentivirinae"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Lentivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_327045 .

obo:NCBITaxon_11652
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_11673
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "FIV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "feline immunodeficiency virus FIV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Feline immunodeficiency virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11646 .

obo:NCBITaxon_11723
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:11677"^^xsd:string, "NCBITaxon:11739"^^xsd:string, "NCBITaxon:11740"^^xsd:string ;
    oboInOwl:hasBroadSynonym "CIV"^^xsd:string, "SIV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Chimpanzee immunodeficiency virus"^^xsd:string, "Chimpanzee immunodeficiency virus (SIV(CPZ))"^^xsd:string, "Simian immunodeficiency virus SIVcpz"^^xsd:string, "simian immunodeficiency virus SIV"^^xsd:string, "simian immunodeficiency virus, SIV"^^xsd:string, "simian immunodeficiency viruses SIV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Simian immunodeficiency virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11646 .

obo:NCBITaxon_117565
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "fish"^^xsd:string, "fishes"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Agnatha"^^xsd:string, "Hyperotreti"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Myxini"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_7742 .

obo:NCBITaxon_117571
    obo:IAO_0000111 "Euteleostomi"^^xsd:string ;
    obo:IAO_0000118 "bony vertebrates"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasAlternativeId "NCBITaxon:40673"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "bony vertebrates"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Euteleostomi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_7742 .

obo:NCBITaxon_11768
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:11920"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Feline leukemia provirus"^^xsd:string, "feline leukemia virus FeLV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Feline leukemia virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_153135 .

obo:NCBITaxon_11901
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "BLV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "bovine leukemia virus BLV"^^xsd:string, "bovine leukemia virus, BLV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine leukemia virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_327045 .

obo:NCBITaxon_119088
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Enoplea"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33317 .

obo:NCBITaxon_11974
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Caliciviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_464095 .

obo:NCBITaxon_11976
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12806"^^xsd:string, "NCBITaxon:31701"^^xsd:string ;
    oboInOwl:hasBroadSynonym "RHDV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Rabbit haemorrhagic disease virus"^^xsd:string, "rabbit hemorrhagic disease virus RHDV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rabbit hemorrhagic disease virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11974 .

obo:NCBITaxon_11978
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "FCV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Feline vesivirus"^^xsd:string, "feline calicivirus FCV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Feline calicivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11974 .

obo:NCBITaxon_12058
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Picornavirus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Picornaviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_464095 .

obo:NCBITaxon_12059
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:12128"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Enteroviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Enterovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12058 .

obo:NCBITaxon_12066
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Coxsackievirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12059 .

obo:NCBITaxon_12080
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasBroadSynonym "HPV-1"^^xsd:string, "PV1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human poliovirus type 1"^^xsd:string, "Polio virus 1"^^xsd:string, "Poliovirus 1"^^xsd:string, "Poliovirus type 1"^^xsd:string, "poliovirus type 1 PV1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human poliovirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_138950 .

obo:NCBITaxon_12083
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasBroadSynonym "HPV-2"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human Poliovirus type 2"^^xsd:string, "Poliovirus 2"^^xsd:string, "Poliovirus type 2"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human poliovirus 2"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_138950 .

obo:NCBITaxon_12086
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasBroadSynonym "HPV-3"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human poliovirus type 3"^^xsd:string, "Polio virus 3"^^xsd:string, "Poliovirus 3"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Poliovirus type 3"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human poliovirus 3"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_138950 .

obo:NCBITaxon_12091
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Hepatovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12058 .

obo:NCBITaxon_12092
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HAV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Hepatitis A virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Hepatovirus A"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12091 .

obo:NCBITaxon_12110
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "FMDV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Foot and mouth disease virus"^^xsd:string, "foot and mouth disease virus FMDV"^^xsd:string, "foot-and-mouth disease virus FMDV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Foot-and-mouth disease virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12058 .

obo:NCBITaxon_121791
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Nipah virus"^^xsd:string, "Nipah-virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Nipah henipavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_260964 .

obo:NCBITaxon_1224
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_phylum ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11321122"^^xsd:string, "PMID:11542017"^^xsd:string, "PMID:11837318"^^xsd:string, "PMID:26654112"^^xsd:string, "PMID:29458499"^^xsd:string ;
    oboInOwl:hasExactSynonym "purple bacteria"^^xsd:string, "purple bacteria and relatives"^^xsd:string, "purple non-sulfur bacteria"^^xsd:string, "purple photosynthetic bacteria"^^xsd:string, "purple photosynthetic bacteria and relatives"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Alphaproteobacteraeota"^^xsd:string, "Alphaproteobacteriota"^^xsd:string, "proteobacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Proteobacteria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2 .

obo:NCBITaxon_1236
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:23334881"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Proteobacteria gamma subdivision"^^xsd:string, "Purple bacteria, gamma subdivision"^^xsd:string, "g-proteobacteria"^^xsd:string, "gamma proteobacteria"^^xsd:string, "gamma subdivision"^^xsd:string, "gamma subgroup"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Gammaproteobacteria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1224 .

obo:NCBITaxon_1238
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1371057"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Piscirickettsia salmonis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_72273 .

obo:NCBITaxon_1239
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_phylum ;
    oboInOwl:hasAlternativeId "NCBITaxon:31968"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10555317"^^xsd:string, "PMID:11034484"^^xsd:string, "PMID:11542017"^^xsd:string, "PMID:15143038"^^xsd:string, "PMID:25403554"^^xsd:string, "PMID:26654112"^^xsd:string, "PMID:29458499"^^xsd:string ;
    oboInOwl:hasExactSynonym "low G+C Gram-positive bacteria"^^xsd:string, "low GC Gram+"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillaeota"^^xsd:string, "Bacillota"^^xsd:string, "Bacillus/Clostridium group"^^xsd:string, "Clostridium group firmicutes"^^xsd:string, "Firmacutes"^^xsd:string, "Low G+C firmicutes"^^xsd:string, "clostridial firmicutes"^^xsd:string, "firmicutes"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Firmicutes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1783272 .

obo:NCBITaxon_12455
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "BDV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:25449305"^^xsd:string ;
    oboInOwl:hasExactSynonym "Borna disease virus BDV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Borna disease virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11157 .

obo:NCBITaxon_12475
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12682"^^xsd:string ;
    oboInOwl:hasBroadSynonym "HDV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Hepatitis D virus"^^xsd:string, "hepatitis delta virus HDV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Hepatitis delta virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10239 .

obo:NCBITaxon_12618
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "CAV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Chicken infectious anemia virus"^^xsd:string, "chicken anaemia agent CAA"^^xsd:string, "chicken anemia virus CAV"^^xsd:string, "chicken anemia virus, CAV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "chicken anaemia agent virus CAA"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chicken anemia virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10239 .

obo:NCBITaxon_12637
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Dengue virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11051 .

obo:NCBITaxon_12721
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HIV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "AIDS virus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human immunodeficiency virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11646 .

obo:NCBITaxon_1279
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319469"^^xsd:string, "PMID:10319495"^^xsd:string, "PMID:10425778"^^xsd:string, "PMID:10758876"^^xsd:string, "PMID:12656157"^^xsd:string, "PMID:17220435"^^xsd:string, "PMID:9734063"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Aurococcus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Staphylococcus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1385 .

obo:NCBITaxon_1280
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:325213"^^xsd:string, "NCBITaxon:46170"^^xsd:string, "NCBITaxon:72759"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:31023808"^^xsd:string, "PMID:8573498"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Micrococcus aureus"^^xsd:string, "Micrococcus pyogenes"^^xsd:string, "Staphlococcus pyogenes citreus"^^xsd:string, "Staphylococcus aureus subsp. anaerobius"^^xsd:string, "Staphylococcus pyogenes aureus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Staphylococcus aureus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1279 .

obo:NCBITaxon_12814
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "respiratory syncytial virus RS"^^xsd:string, "respiratory syncytial virus RS virus"^^xsd:string, "respiratory syncytial virus RSV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Respiratory syncytial virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11244 .

obo:NCBITaxon_12845
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Swine influenza virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_35324 .

obo:NCBITaxon_1301
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10555340"^^xsd:string, "PMID:14657115"^^xsd:string, "PMID:1720654"^^xsd:string, "PMID:19620365"^^xsd:string, "PMID:19880633"^^xsd:string, "PMID:7537076"^^xsd:string, "PMID:8995803"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Streptococcus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91061 .

obo:NCBITaxon_1307
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:23245487"^^xsd:string, "PMID:5220563"^^xsd:string, "PMID:9731300"^^xsd:string, "PMID:9734065"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Streptococcus suis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1301 .

obo:NCBITaxon_1311
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:76757"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15774692"^^xsd:string, "PMID:8995807"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Streptoccocus de la mammite"^^xsd:string, "Streptococcus agalactiae contagiosae"^^xsd:string, "Streptococcus difficile"^^xsd:string, "Streptococcus difficilis"^^xsd:string, "Streptococcus mastitidis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Streptococcus agalactiae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1301 .

obo:NCBITaxon_1313
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Diplococcus pneumoniae"^^xsd:string, "Micrococcus pneumoniae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1301 .

obo:NCBITaxon_1314
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Micrococcus scarlatinae"^^xsd:string, "Streptococcus erysipelatos"^^xsd:string, "Streptococcus hemolyticus"^^xsd:string, "Streptococcus scarlatinae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Streptococcus pyogenes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1301 .

obo:NCBITaxon_1335626
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "MERS"^^xsd:string, "MERS-CoV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "MERS coronavirus"^^xsd:string, "MERS virus"^^xsd:string, "Middle East Respiratory Syndrome Coronavirus (MERS-CoV)"^^xsd:string, "Middle East respiratory syndrome coronavirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Middle East respiratory syndrome-related coronavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_694002 .

obo:NCBITaxon_1336
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Streptococcus equi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1301 .

obo:NCBITaxon_13488
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Dicentrarchus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1489388 .

obo:NCBITaxon_13489
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "European sea bass"^^xsd:string, "European seabass"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Labrax labrax"^^xsd:string, "Morone labrax"^^xsd:string, "Perca labrax"^^xsd:string, "Roccus labrax"^^xsd:string, "Sciaena labrax"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Dicentrarchus labrax"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_13488 .

obo:NCBITaxon_136
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11075904"^^xsd:string, "PMID:11542017"^^xsd:string, "PMID:16558735"^^xsd:string, "PMID:1917844"^^xsd:string, "PMID:23908650"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "spirochetes"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Spirochaetales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_203692 .

obo:NCBITaxon_1385
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus/Staphylococcus group"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bacillales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91061 .

obo:NCBITaxon_1386
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10843090"^^xsd:string, "PMID:11491334"^^xsd:string, "PMID:1742196"^^xsd:string, "PMID:2223602"^^xsd:string, "PMID:23475340"^^xsd:string, "PMID:7727277"^^xsd:string, "PMID:8138135"^^xsd:string, "PMID:8863420"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bacillus"^^xsd:string, "Bacillus rRNA group 1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bacillus <firmicutes>"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1385 .

obo:NCBITaxon_138950
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:138953"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Enterovirus EV-C"^^xsd:string, "Human enterovirus C"^^xsd:string, "Poliovirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Enterovirus C"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12059 .

obo:NCBITaxon_139
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1380285"^^xsd:string, "PMID:1503971"^^xsd:string, "PMID:24744012"^^xsd:string, "PMID:7699027"^^xsd:string, "PMID:7981102"^^xsd:string, "PMID:8995796"^^xsd:string, "PMID:9336916"^^xsd:string ;
    oboInOwl:hasExactSynonym "Lyme disease spirochete"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Borrelia burgdorferi"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Borreliella burgdorferi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_64895 .

obo:NCBITaxon_1392
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1494525"^^xsd:string, "NCBITaxon:1494531"^^xsd:string, "NCBITaxon:1494577"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:8123566"^^xsd:string ;
    oboInOwl:hasExactSynonym "anthrax"^^xsd:string, "anthrax bacterium"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus cereus var. anthracis"^^xsd:string, "Bacteridium anthracis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bacillus anthracis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1386 .

obo:NCBITaxon_1437010
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:11743200"^^xsd:string, "PMID:11791233"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Boreotheria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Boreoeutheria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_40674 .

obo:NCBITaxon_1485
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:69207"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:26643615"^^xsd:string, "PMID:27488356"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Anaerobacter"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Clostridium"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1239 .

obo:NCBITaxon_1489388
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_cohort ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Euteleosteomorpha"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_186625 .

obo:NCBITaxon_1491
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:29368"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10028279"^^xsd:string, "PMID:15244052"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus botulinus"^^xsd:string, "Bacillus putrificus"^^xsd:string, "Botulobacillus botulinus"^^xsd:string, "Clostridium putrificum"^^xsd:string, "Ermengemillus botulinus"^^xsd:string, "Pacinia putrifica"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Clostridium botulinum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1485 .

obo:NCBITaxon_149539
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasAlternativeId "NCBITaxon:2588446"^^xsd:string, "NCBITaxon:2588447"^^xsd:string, "NCBITaxon:41533"^^xsd:string, "NCBITaxon:592"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10758910"^^xsd:string ;
    oboInOwl:hasExactSynonym "Salmonella enterica serovar Enteritidis"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus enteritidis"^^xsd:string, "Salmonella enteritidis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmonella enterica subsp. enterica serovar Enteritidis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_59201 .

obo:NCBITaxon_149595
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine parainfluenza virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11158 .

obo:NCBITaxon_150052
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subspecies ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11043982"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersinia enterocolitica subsp. enterocolitica"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_629 .

obo:NCBITaxon_1502
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1683536"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1374625"^^xsd:string, "PMID:184898"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "'Clostridium plagarum'"^^xsd:string, "Bacillus perfringens"^^xsd:string, "Bacterium welchii"^^xsd:string, "Clostridium plagarum"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Clostridium perfringens"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1485 .

obo:NCBITaxon_1506574
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:10781"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Parvovirus"^^xsd:string, "Parvoviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Protoparvovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_40119 .

obo:NCBITaxon_1513
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus tetani"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Clostridium tetani"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1485 .

obo:NCBITaxon_151340
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:20206957"^^xsd:string ;
    oboInOwl:hasExactSynonym "Papillomavirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Papillomaviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732415 .

obo:NCBITaxon_153135
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:11762"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "MLV-related viruses"^^xsd:string, "Mammalian type C retrovirus group"^^xsd:string, "Mammalian type C retroviruses"^^xsd:string, "mammalian type C oncoviruses"^^xsd:string, "type C oncoviruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Gammaretrovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_327045 .

obo:NCBITaxon_1549675
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Galloanseri"^^xsd:string, "ducks, geese, chickens, fowl, quail, currasows and allies"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Galloanserae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_8825 .

obo:NCBITaxon_160
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Microspironema pallidum"^^xsd:string, "Spirillum pallidum"^^xsd:string, "Spirochaeta pallida"^^xsd:string, "Spironema pallidum"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Treponema pallidum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_136 .

obo:NCBITaxon_162145
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "HMPV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Human metapneumovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_162387 .

obo:NCBITaxon_162387
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Metapneumovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11244 .

obo:NCBITaxon_1639
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1634566"^^xsd:string, "NCBITaxon:2293539"^^xsd:string, "NCBITaxon:2293540"^^xsd:string, "NCBITaxon:2293541"^^xsd:string, "NCBITaxon:2293542"^^xsd:string, "NCBITaxon:2293543"^^xsd:string, "NCBITaxon:2293544"^^xsd:string, "NCBITaxon:2293545"^^xsd:string, "NCBITaxon:2293546"^^xsd:string, "NCBITaxon:2293547"^^xsd:string, "NCBITaxon:2364651"^^xsd:string, "NCBITaxon:2364652"^^xsd:string, "NCBITaxon:2364653"^^xsd:string, "NCBITaxon:2364654"^^xsd:string, "NCBITaxon:2364655"^^xsd:string, "NCBITaxon:2364656"^^xsd:string, "NCBITaxon:2364657"^^xsd:string, "NCBITaxon:2364658"^^xsd:string, "NCBITaxon:2364659"^^xsd:string, "NCBITaxon:2364660"^^xsd:string, "NCBITaxon:2482733"^^xsd:string, "NCBITaxon:2482734"^^xsd:string, "NCBITaxon:2482735"^^xsd:string, "NCBITaxon:2482736"^^xsd:string, "NCBITaxon:2482737"^^xsd:string, "NCBITaxon:2482738"^^xsd:string, "NCBITaxon:2482739"^^xsd:string, "NCBITaxon:2482740"^^xsd:string, "NCBITaxon:2482741"^^xsd:string, "NCBITaxon:2482742"^^xsd:string, "NCBITaxon:2482743"^^xsd:string, "NCBITaxon:2482744"^^xsd:string, "NCBITaxon:2482745"^^xsd:string, "NCBITaxon:2482746"^^xsd:string, "NCBITaxon:2482747"^^xsd:string, "NCBITaxon:2482748"^^xsd:string, "NCBITaxon:2482749"^^xsd:string, "NCBITaxon:2484857"^^xsd:string, "NCBITaxon:2484858"^^xsd:string, "NCBITaxon:2485082"^^xsd:string, "NCBITaxon:2485083"^^xsd:string, "NCBITaxon:2485084"^^xsd:string, "NCBITaxon:2485085"^^xsd:string, "NCBITaxon:2485086"^^xsd:string, "NCBITaxon:2485087"^^xsd:string, "NCBITaxon:2485088"^^xsd:string, "NCBITaxon:2485089"^^xsd:string, "NCBITaxon:2485090"^^xsd:string, "NCBITaxon:2485091"^^xsd:string, "NCBITaxon:2485092"^^xsd:string, "NCBITaxon:2485093"^^xsd:string, "NCBITaxon:2485094"^^xsd:string, "NCBITaxon:2485095"^^xsd:string, "NCBITaxon:2485096"^^xsd:string, "NCBITaxon:2486732"^^xsd:string, "NCBITaxon:2486733"^^xsd:string, "NCBITaxon:2486734"^^xsd:string, "NCBITaxon:2486735"^^xsd:string, "NCBITaxon:2486736"^^xsd:string, "NCBITaxon:2486737"^^xsd:string, "NCBITaxon:2486738"^^xsd:string, "NCBITaxon:2486739"^^xsd:string, "NCBITaxon:2486740"^^xsd:string, "NCBITaxon:2486741"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:17773427"^^xsd:string, "PMID:1906732"^^xsd:string, "PMID:8782698"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacterium monocytogenes"^^xsd:string, "Bacterium monocytogenes hominis"^^xsd:string, "Corynebacterium infantisepticum"^^xsd:string, "Corynebacterium parvulum"^^xsd:string, "Erysipelothrix monocytogenes"^^xsd:string, "Listerella hepatolytica"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Listeria monocytogenes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1385 .

obo:NCBITaxon_1648
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1503975"^^xsd:string, "PMID:8427802"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus insidiosus"^^xsd:string, "Bacillus rhusiopathiae suis"^^xsd:string, "Bacterium rhusiopathiae"^^xsd:string, "Erysipelothrix erysipeloides"^^xsd:string, "Erysipelothrix insidiosa"^^xsd:string, "Erysipelothrix murisepticus"^^xsd:string, "Erysipelothrix porci"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Erysipelothrix rhusiopathiae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1239 .

obo:NCBITaxon_1649845
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank <http://purl.obolibrary.org/obo/NCBITaxon#_species_group> ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersinia pseudotuberculosis complex"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_629 .

obo:NCBITaxon_1653394
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mammarenavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1980410 .

obo:NCBITaxon_171
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:29512"^^xsd:string, "NCBITaxon:29514"^^xsd:string, "NCBITaxon:29516"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10425768"^^xsd:string, "PMID:1581182"^^xsd:string, "PMID:19868121"^^xsd:string, "PMID:9103653"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leptospira"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_203692 .

obo:NCBITaxon_1716
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:144193"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10425754"^^xsd:string, "PMID:19661509"^^xsd:string, "PMID:29760685"^^xsd:string, "PMID:30186281"^^xsd:string, "PMID:7547284"^^xsd:string, "PMID:7547291"^^xsd:string, "PMID:7547293"^^xsd:string, "PMID:8186090"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Turicella"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Corynebacterium"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_85007 .

obo:NCBITaxon_1717
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:7729671"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus diphtheriae"^^xsd:string, "Bacterium diphtheriae"^^xsd:string, "Microsporon diphthericum"^^xsd:string, "Microsporon diphtheriticum"^^xsd:string, "Mycobacterium diphtheriae"^^xsd:string, "Pacinia loeffleri"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Corynebacterium diphtheriae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1716 .

obo:NCBITaxon_1719
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus pseudotuberculosis"^^xsd:string, "Bacillus pseudotuberculosis-ovis"^^xsd:string, "Corynebacterium ovis"^^xsd:string, "Corynebacterium preisz-nocardi"^^xsd:string, "Corynebacterium pseudotuberculosis-ovis"^^xsd:string, "Mycobacterium tuberculosis-ovis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Corynebacterium pseudotuberculosis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1716 .

obo:NCBITaxon_173
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:2843297"^^xsd:string, "NCBITaxon:2843299"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15545494"^^xsd:string, "PMID:19867994"^^xsd:string, "PMID:19868337"^^xsd:string, "PMID:19972157"^^xsd:string, "PMID:25288661"^^xsd:string, "PMID:9542090"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leptospira icteroides"^^xsd:string, "Spirochaeta biflexa"^^xsd:string, "Spirochaeta icterogenes"^^xsd:string, "Spirochaeta icterohaemorrhagiae"^^xsd:string, "Spirochaeta interrogans"^^xsd:string, "Spirochaeta nodosa"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leptospira interrogans"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_171 .

obo:NCBITaxon_175121
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Passeroidea"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_8825 .

obo:NCBITaxon_176
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leptospira hardjo"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leptospira interrogans serovar Hardjo"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_173 .

obo:NCBITaxon_1763
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1380284"^^xsd:string, "PMID:1581193"^^xsd:string, "PMID:16014496"^^xsd:string, "PMID:1883713"^^xsd:string, "PMID:2275850"^^xsd:string, "PMID:29497402"^^xsd:string, "PMID:31296783"^^xsd:string, "PMID:31649146"^^xsd:string, "PMID:31649147"^^xsd:string, "PMID:34554081"^^xsd:string, "PMID:7547284"^^xsd:string, "PMID:7547304"^^xsd:string, "PMID:7907223"^^xsd:string, "PMID:8863452"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycobacterium"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_85007 .

obo:NCBITaxon_1764
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:2397193"^^xsd:string, "PMID:8347508"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus tuberculosis gallinarum"^^xsd:string, "Mycobacterium tuberculosis avium"^^xsd:string, "Mycobacterium tuberculosis typus gallinaceus"^^xsd:string, "Tuberculose des oiseaux"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycobacterium avium"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1763 .

obo:NCBITaxon_1765
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_biotype ;
    oboInOwl:hasAlternativeId "NCBITaxon:115863"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10618079"^^xsd:string, "PMID:11931153"^^xsd:string, "PMID:14657105"^^xsd:string, "PMID:29205127"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Mycobacterium bovis"^^xsd:string, "Mycobacterium tuberculosis typus bovinus"^^xsd:string, "Mycobacterium tuberculosis var. bovis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycobacterium tuberculosis variant bovis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1773 .

obo:NCBITaxon_1773
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:2528440"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:29205127"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus tuberculosis"^^xsd:string, "Bacterium tuberculosis"^^xsd:string, "Mycobacterium tuberculosis typus humanus"^^xsd:string, "Mycobacterium tuberculosis var. hominis"^^xsd:string, "Mycobacterium tuberculosis variant tuberculosis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycobacterium tuberculosis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1763 .

obo:NCBITaxon_1781
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:12089250"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Mycobacterium balnei"^^xsd:string, "Mycobacterium platypoecilus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycobacterium marinum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1763 .

obo:NCBITaxon_1783272
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:18988685"^^xsd:string, "PMID:23851394"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Terrabacteria group"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2 .

obo:NCBITaxon_180252
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Marek's disease-like viruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mardivirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10293 .

obo:NCBITaxon_180255
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Infectious laryngo-tracheitis-like viruses"^^xsd:string, "Infectious laryngotracheitis-like viruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Iltovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10293 .

obo:NCBITaxon_186537
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Marburg-like viruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Marburgvirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11266 .

obo:NCBITaxon_186625
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Clupeocephala"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_7898 .

obo:NCBITaxon_186778
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Novirhabdovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11270 .

obo:NCBITaxon_1868215
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthopneumovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11244 .

obo:NCBITaxon_1903411
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:27620848"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersiniaceae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91347 .

obo:NCBITaxon_194
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11542086"^^xsd:string, "PMID:12361288"^^xsd:string, "PMID:16627635"^^xsd:string, "PMID:1704793"^^xsd:string, "PMID:19801389"^^xsd:string, "PMID:29034857"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Campylobacter"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_213849 .

obo:NCBITaxon_196
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11321120"^^xsd:string, "PMID:1354478"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Spirillum fetus"^^xsd:string, "Vibrio fetus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Campylobacter fetus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_194 .

obo:NCBITaxon_197
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:2172531"^^xsd:string, "NCBITaxon:2182326"^^xsd:string, "NCBITaxon:2201165"^^xsd:string, "NCBITaxon:2211407"^^xsd:string, "NCBITaxon:2211408"^^xsd:string, "NCBITaxon:2211409"^^xsd:string, "NCBITaxon:2293848"^^xsd:string, "NCBITaxon:2293849"^^xsd:string, "NCBITaxon:2293850"^^xsd:string, "NCBITaxon:2303571"^^xsd:string, "NCBITaxon:2305452"^^xsd:string, "NCBITaxon:2305453"^^xsd:string, "NCBITaxon:2305454"^^xsd:string, "NCBITaxon:2305455"^^xsd:string, "NCBITaxon:2305456"^^xsd:string, "NCBITaxon:2305457"^^xsd:string, "NCBITaxon:2305458"^^xsd:string, "NCBITaxon:2305459"^^xsd:string, "NCBITaxon:2340789"^^xsd:string, "NCBITaxon:2478524"^^xsd:string, "NCBITaxon:2572055"^^xsd:string, "NCBITaxon:2572062"^^xsd:string, "NCBITaxon:2572070"^^xsd:string, "NCBITaxon:2572072"^^xsd:string, "NCBITaxon:2572075"^^xsd:string, "NCBITaxon:2572080"^^xsd:string, "NCBITaxon:2572086"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11321120"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Campylobacter fetus subsp. jejuni"^^xsd:string, "Vibrio hepaticus"^^xsd:string, "Vibrio jejuni"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Campylobacter jejuni"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_194 .

obo:NCBITaxon_197911
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Influenzavirus A"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Alphainfluenzavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11308 .

obo:NCBITaxon_197912
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Influenzavirus B"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Betainfluenzavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11308 .

obo:NCBITaxon_197913
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Influenzavirus C"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Gammainfluenzavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11308 .

obo:NCBITaxon_1980410
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bunyavirales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2497571 .

obo:NCBITaxon_2
    obo:IAO_0000111 "Bacteria"^^xsd:string ;
    obo:IAO_0000118 "eubacteria"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superkingdom ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10425795"^^xsd:string, "PMID:10425796"^^xsd:string, "PMID:10425797"^^xsd:string, "PMID:10490293"^^xsd:string, "PMID:10843050"^^xsd:string, "PMID:10939651"^^xsd:string, "PMID:10939673"^^xsd:string, "PMID:10939677"^^xsd:string, "PMID:11211268"^^xsd:string, "PMID:11321083"^^xsd:string, "PMID:11321113"^^xsd:string, "PMID:11411719"^^xsd:string, "PMID:11540071"^^xsd:string, "PMID:11542017"^^xsd:string, "PMID:11542087"^^xsd:string, "PMID:11760965"^^xsd:string, "PMID:12054223"^^xsd:string, "PMID:2112744"^^xsd:string, "PMID:270744"^^xsd:string, "PMID:7520741"^^xsd:string, "PMID:8123559"^^xsd:string, "PMID:8186100"^^xsd:string, "PMID:8590690"^^xsd:string, "PMID:9103655"^^xsd:string, "PMID:9336922"^^xsd:string ;
    oboInOwl:hasExactSynonym "eubacteria"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Monera"^^xsd:string, "Procaryotae"^^xsd:string, "Prokaryota"^^xsd:string, "Prokaryotae"^^xsd:string, "bacteria"^^xsd:string, "prokaryote"^^xsd:string, "prokaryotes"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bacteria"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0100026 .

obo:NCBITaxon_200644
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Flavobacteriales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_976 .

obo:NCBITaxon_203692
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11837318"^^xsd:string, "PMID:25288668"^^xsd:string, "PMID:26654112"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "\"Leptospiria\" Cavalier-Smith 2020"^^xsd:string, "Spirochaetes"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Spirochaetia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2 .

obo:NCBITaxon_204722
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:12271122"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella suis str. 1330"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Brucella melitensis biovar Suis str. 1330"^^xsd:string, "Brucella suis ATCC 23444"^^xsd:string, "Brucella suis NCTC 10316"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella suis 1330"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_29461 .

obo:NCBITaxon_205488
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:11268"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Ebola virus EBO"^^xsd:string, "unidentified Ebola virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Ebola virus sp."^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11266 .

obo:NCBITaxon_206351
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:23575986"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Neisseriales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_28216 .

obo:NCBITaxon_2092
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:4"^^xsd:string, "PMID:13403276"^^xsd:string, "PMID:16350067"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Borrelomycetaceae"^^xsd:string, "Parasitaceae"^^xsd:string, "Pleuropneumoniaceae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycoplasmataceae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1783272 .

obo:NCBITaxon_2093
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:29500"^^xsd:string, "NCBITaxon:57371"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:4"^^xsd:string, "PMID:10826816"^^xsd:string, "PMID:11321109"^^xsd:string, "PMID:11411711"^^xsd:string, "PMID:11931184"^^xsd:string, "PMID:13403276"^^xsd:string, "PMID:15176735"^^xsd:string, "PMID:16350067"^^xsd:string, "PMID:16403858"^^xsd:string, "PMID:25288662"^^xsd:string, "PMID:8863441"^^xsd:string, "PMID:8995799"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Asterococcus"^^xsd:string, "Asteromyces"^^xsd:string, "Borrelomyces"^^xsd:string, "Bovimyces"^^xsd:string, "Eperythrozoon"^^xsd:string, "Haemobartonella"^^xsd:string, "Pleuropneumonia"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycoplasma"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2092 .

obo:NCBITaxon_2096
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:4"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycoplasma gallisepticum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2093 .

obo:NCBITaxon_2099
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:4"^^xsd:string, "PMID:11491338"^^xsd:string, "PMID:1316139"^^xsd:string, "PMID:1374621"^^xsd:string, "PMID:14323369"^^xsd:string, "PMID:8573513"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Mycoplasma suipneumoniae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycoplasma hyopneumoniae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2093 .

obo:NCBITaxon_210
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:219"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11931154"^^xsd:string, "PMID:1995031"^^xsd:string, "PMID:8186097"^^xsd:string, "PMID:8494747"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Campylobacter pylori"^^xsd:string, "Campylobacter pylori subsp. pylori"^^xsd:string, "Campylobacter pyloridis"^^xsd:string, "Helicobacter nemestrinae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Helicobacter pylori"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_213849 .

obo:NCBITaxon_2109
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:4"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Mycoplasma synoviae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mycoplasmopsis synoviae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2092 .

obo:NCBITaxon_211880
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leptospira canicola"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leptospira interrogans serovar Canicola"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_173 .

obo:NCBITaxon_213849
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:16403855"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Campylobacterales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_68525 .

obo:NCBITaxon_2157
    obo:IAO_0000111 "Archaea"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superkingdom ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10425795"^^xsd:string, "PMID:10425796"^^xsd:string, "PMID:10425797"^^xsd:string, "PMID:10490293"^^xsd:string, "PMID:10843050"^^xsd:string, "PMID:10939651"^^xsd:string, "PMID:10939673"^^xsd:string, "PMID:10939677"^^xsd:string, "PMID:11211268"^^xsd:string, "PMID:11321083"^^xsd:string, "PMID:11321113"^^xsd:string, "PMID:11411719"^^xsd:string, "PMID:11540071"^^xsd:string, "PMID:11541975"^^xsd:string, "PMID:11542064"^^xsd:string, "PMID:11542149"^^xsd:string, "PMID:11760965"^^xsd:string, "PMID:12054223"^^xsd:string, "PMID:2112744"^^xsd:string, "PMID:25527841"^^xsd:string, "PMID:270744"^^xsd:string, "PMID:8123559"^^xsd:string, "PMID:8590690"^^xsd:string, "PMID:9103655"^^xsd:string, "PMID:9336922"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Archaebacteria"^^xsd:string, "Mendosicutes"^^xsd:string, "Metabacteria"^^xsd:string, "Monera"^^xsd:string, "Procaryotae"^^xsd:string, "Prokaryota"^^xsd:string, "Prokaryotae"^^xsd:string, "archaea"^^xsd:string, "prokaryote"^^xsd:string, "prokaryotes"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Archaea"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0100026 .

obo:NCBITaxon_224914
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11756688"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Brucella melitensis ATCC 23456"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella melitensis bv. 1 str. 16M"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_29459 .

obo:NCBITaxon_234
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:28066370"^^xsd:string, "PMID:8573514"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_28211 .

obo:NCBITaxon_235
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella melitensis bv. Abortus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "\"Bacillus of abortion\" Bang 1897"^^xsd:string, "Bacterium abortus"^^xsd:string, "Brucella melitensis biovar Abortus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella abortus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_234 .

obo:NCBITaxon_236
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella melitensis bv. Ovis"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Brucella melitensis biovar Ovis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella ovis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_234 .

obo:NCBITaxon_2497569
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_phylum ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Negative-strand RNA viruses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Negarnaviricota"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732396 .

obo:NCBITaxon_2497571
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subphylum ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Polyploviricotina"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2497569 .

obo:NCBITaxon_2501931
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthocoronavirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11118 .

obo:NCBITaxon_2559587
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "RNA viruses"^^xsd:string, "RNA viruses and viroids"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Riboviria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10239 .

obo:NCBITaxon_2560076
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthoparamyxovirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11158 .

obo:NCBITaxon_260963
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Avulavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11158 .

obo:NCBITaxon_260964
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Henipavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2560076 .

obo:NCBITaxon_2611341
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:30257078"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Metamonada"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2759 .

obo:NCBITaxon_2611352
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Discoba"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2759 .

obo:NCBITaxon_262698
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15805518"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella abortus biovar 1 str. 9-941"^^xsd:string, "Brucella abortus bv. 1 strain 9-941"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella abortus bv. 1 str. 9-941"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_235 .

obo:NCBITaxon_263
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacterium tularense"^^xsd:string, "Brucella tularensis"^^xsd:string, "Francisella tularense"^^xsd:string, "Pasteurella tularensis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Francisella tularensis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_72273 .

obo:NCBITaxon_2697049
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasBroadSynonym "SARS-CoV-2" ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "2019-nCoV"^^xsd:string, "COVID-19 virus"^^xsd:string, "HCoV-19"^^xsd:string, "HCoV-19; COVID-19 virus; SARS-2; Human coronavirus 2019; SARS-CoV2; SARS2; 2019-nCoV", "Human coronavirus 2019"^^xsd:string, "SARS-2"^^xsd:string, "SARS-CoV2"^^xsd:string, "SARS2"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy" ;
    a owl:Class ;
    rdfs:label "Severe acute respiratory syndrome coronavirus 2" ;
    rdfs:subClassOf obo:NCBITaxon_694002, obo:NCBITaxon_694009 .

obo:NCBITaxon_2732005
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_kingdom ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bamfordvirae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10239 .

obo:NCBITaxon_2732092
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_kingdom ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Shotokuvirae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10239 .

obo:NCBITaxon_2732396
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_kingdom ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthornavirae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2559587 .

obo:NCBITaxon_2732406
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_phylum ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Kitrinoviricota"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732396 .

obo:NCBITaxon_2732415
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_phylum ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Cossaviricota"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732092 .

obo:NCBITaxon_2732461
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Alsuviricetes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732406 .

obo:NCBITaxon_2732506
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pisoniviricetes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732396 .

obo:NCBITaxon_2732514
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Revtraviricetes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2559587 .

obo:NCBITaxon_2732525
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pokkesviricetes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732005 .

obo:NCBITaxon_2759
    obo:IAO_0000111 "Eukaryota"^^xsd:string ;
    obo:IAO_0000118 "eucaryotes"^^xsd:string, "eukaryotes"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superkingdom ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:23020233"^^xsd:string, "PMID:30257078"^^xsd:string ;
    oboInOwl:hasExactSynonym "eucaryotes"^^xsd:string, "eukaryotes"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Eucarya"^^xsd:string, "Eucaryotae"^^xsd:string, "Eukarya"^^xsd:string, "Eukaryotae"^^xsd:string, "eukaryotes"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Eukaryota"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0100026 .

obo:NCBITaxon_27592
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9895 .

obo:NCBITaxon_28115
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:29525"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1503973"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacteroides macacae"^^xsd:string, "Bacteroides melaninogenicus subsp. macacae"^^xsd:string, "Bacteroides salivosus"^^xsd:string, "Porphyromonas salivosa"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Porphyromonas macacae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_836 .

obo:NCBITaxon_28174
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:707"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Listonella ordalii"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Vibrio ordalii"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_641 .

obo:NCBITaxon_28211
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11541974"^^xsd:string, "PMID:11837318"^^xsd:string, "PMID:16166687"^^xsd:string, "PMID:16403855"^^xsd:string, "PMID:19060069"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Alphabacteria"^^xsd:string, "Proteobacteria alpha subdivision"^^xsd:string, "Purple bacteria, alpha subdivision"^^xsd:string, "a-proteobacteria"^^xsd:string, "alpha proteobacteria"^^xsd:string, "alpha subdivision"^^xsd:string, "alpha subgroup"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Alphaproteobacteria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1224 .

obo:NCBITaxon_28216
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:16403855"^^xsd:string, "PMID:28581923"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Proteobacteria beta subdivision"^^xsd:string, "Purple bacteria, beta subdivision"^^xsd:string, "b-proteobacteria"^^xsd:string, "beta proteobacteria"^^xsd:string, "beta subdivision"^^xsd:string, "beta subgroup"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Betaproteobacteria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1224 .

obo:NCBITaxon_28344
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12796"^^xsd:string, "NCBITaxon:70172"^^xsd:string ;
    oboInOwl:hasBroadSynonym "PRRSV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Porcine reproductive and respiratory syndrome virus (PRRSV)"^^xsd:string, "Porcine respiratory and reproductive syndrome virus"^^xsd:string, "porcine reproductive and respiratory syndrome virus PRRSV"^^xsd:string, "porcine reproductive and respiratory syndrome virus, PRRSV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Porcine reproductive and respiratory syndrome virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_76803 .

obo:NCBITaxon_28450
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1435366"^^xsd:string, "NCBITaxon:1435368"^^xsd:string, "NCBITaxon:1435988"^^xsd:string, "NCBITaxon:1439853"^^xsd:string, "NCBITaxon:1487954"^^xsd:string, "NCBITaxon:1487955"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:12734250"^^xsd:string, "PMID:1283774"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus pseudomallei"^^xsd:string, "Bacterium whitmori"^^xsd:string, "Loefflerella pseudomallei"^^xsd:string, "Malleomyces pseudomallei"^^xsd:string, "Pseudomonas pseudomallei"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Burkholderia pseudomallei"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_80840 .

obo:NCBITaxon_286
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:212745"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10758879"^^xsd:string, "PMID:10939664"^^xsd:string, "PMID:15950132"^^xsd:string, "PMID:18048745"^^xsd:string, "PMID:23918787"^^xsd:string, "PMID:7727274"^^xsd:string, "PMID:9103607"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "\"Chlorobacterium\" Guillebeau 1890, nom. rejic. Opin. 6 (not \"Chlorobacterium\" Lauterborn 1916)"^^xsd:string, "Liquidomonas"^^xsd:string, "Loefflerella"^^xsd:string, "RNA similarity group I"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pseudomonas"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1236 .

obo:NCBITaxon_287
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1224290"^^xsd:string, "NCBITaxon:1437768"^^xsd:string, "NCBITaxon:1437769"^^xsd:string, "NCBITaxon:1437770"^^xsd:string, "NCBITaxon:1508364"^^xsd:string, "NCBITaxon:1607811"^^xsd:string, "NCBITaxon:1607813"^^xsd:string, "NCBITaxon:1683559"^^xsd:string, "NCBITaxon:1683561"^^xsd:string, "NCBITaxon:1851858"^^xsd:string, "NCBITaxon:1851865"^^xsd:string, "NCBITaxon:1860124"^^xsd:string, "NCBITaxon:665948"^^xsd:string, "NCBITaxon:912077"^^xsd:string, "NCBITaxon:931955"^^xsd:string, "NCBITaxon:931956"^^xsd:string, "NCBITaxon:931957"^^xsd:string, "NCBITaxon:931958"^^xsd:string, "NCBITaxon:932477"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus aeruginosus"^^xsd:string, "Bacillus pyocyaneus"^^xsd:string, "Bacterium aeruginosum"^^xsd:string, "Bacterium pyocyaneum"^^xsd:string, "Micrococcus pyocyaneus"^^xsd:string, "Pseudomonas polycolor"^^xsd:string, "Pseudomonas pyocyanea"^^xsd:string, "probable synonym or variety: \"Pseudomonas polycolor\" Clara 1930"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pseudomonas aeruginosa"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_286 .

obo:NCBITaxon_29176
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Neospora caninum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5809 .

obo:NCBITaxon_29258
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_29459
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:8573514"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Micrococcus melitensis"^^xsd:string, "Streptococcus Miletensis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella melitensis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_234 .

obo:NCBITaxon_29461
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella melitensis bv. Suis"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Brucella melitensis biovar Suis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella suis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_234 .

obo:NCBITaxon_29486
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersinia ruckeri"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_629 .

obo:NCBITaxon_29546
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:7547305"^^xsd:string, "PMID:7857801"^^xsd:string, "PMID:7981108"^^xsd:string, "PMID:8123559"^^xsd:string, "PMID:8347512"^^xsd:string, "PMID:9226893"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Candidatus intracellularis"^^xsd:string, "Ileal symbiont intracellularis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Lawsonia intracellularis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_68525 .

obo:NCBITaxon_314145
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:11214318"^^xsd:string, "PMID:11214319"^^xsd:string, "PMID:12878460"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Laurasiatheria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1437010 .

obo:NCBITaxon_314146
    obo:IAO_0000111 "Euarchontoglires"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_superorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:11214319"^^xsd:string, "PMID:12082125"^^xsd:string, "PMID:12878460"^^xsd:string, "PMID:15522813"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Euarchontoglires"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1437010, obo:NCBITaxon_40674 .

obo:NCBITaxon_314147
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:11214319"^^xsd:string, "PMID:12082125"^^xsd:string, "PMID:15522813"^^xsd:string ;
    oboInOwl:hasExactSynonym "Rodents and rabbits"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Glires"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314146 .

obo:NCBITaxon_314293
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_infraorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Anthropoidea"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Simiiformes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314146 .

obo:NCBITaxon_32447
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_32523
    obo:IAO_0000111 "Tetrapoda"^^xsd:string ;
    obo:IAO_0000118 "tetrapods"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "Tetrapoda"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_117571 .

obo:NCBITaxon_32524
    obo:IAO_0000111 "Amniota"^^xsd:string ;
    obo:IAO_0000118 "amniotes"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "amniotes"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Amniota"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_117571, obo:NCBITaxon_32523 .

obo:NCBITaxon_32561
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "diapsids"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Diapsida"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Sauria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_32524 .

obo:NCBITaxon_327045
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Orthoretrovirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732514 .

obo:NCBITaxon_329639
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:186155"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Canine parvovirus-1"^^xsd:string, "Minute virus of canines"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canine minute virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_40119 .

obo:NCBITaxon_33154
    obo:IAO_0000111 "Opisthokonta"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Fungi/Metazoa group"^^xsd:string, "opisthokonts"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Opisthokonta"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2759 .

obo:NCBITaxon_33213
    obo:IAO_0000111 "Bilateria"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bilateria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33154 .

obo:NCBITaxon_33317
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Protostomia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33213 .

obo:NCBITaxon_333774
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "unclassified Papillomaviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_151340 .

obo:NCBITaxon_33550
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_suborder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "guinea pigs and others"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Hystricognathi"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Hystricomorpha"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9989 .

obo:NCBITaxon_33554
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "carnivores"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "carnivores"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Carnivora"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314145 .

obo:NCBITaxon_34085
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:13200095"^^xsd:string, "PMID:22427448"^^xsd:string, "PMID:8240957"^^xsd:string, "PMID:9103649"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Moraxella anatipestifer"^^xsd:string, "Pasteurella anapestifer"^^xsd:string, "Pasteurella anatipestifer"^^xsd:string, "Pfeifferella anatipestifer"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Riemerella anatipestifer"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_200644 .

obo:NCBITaxon_35237
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_35268
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_35278
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_35301
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_353210
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Replication competent viruses"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_153135 .

obo:NCBITaxon_35324
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "unclassified Orthomyxoviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11308 .

obo:NCBITaxon_35325
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_35500
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_infraorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pecora"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91561 .

obo:NCBITaxon_359391
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:16299333"^^xsd:string, "PMID:20462421"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Brucella melitensis biovar Abortus 2308"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella abortus 2308"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_235 .

obo:NCBITaxon_36420
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "H1N1 swine influenza virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_114727 .

obo:NCBITaxon_36855
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella melitensis bv. Canis"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Brucella melitensis biovar Canis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella canis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_234 .

obo:NCBITaxon_37124
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chikungunya virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11019 .

obo:NCBITaxon_379584
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_suborder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Caniformia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33554 .

obo:NCBITaxon_38142
    a owl:Class .

obo:NCBITaxon_38170
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avian reovirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Avian orthoreovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10880 .

obo:NCBITaxon_38345
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1581182"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leptospira grippotyphosa"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leptospira kirschneri serovar Grippotyphosa"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_171 .

obo:NCBITaxon_38525
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avian pneumovirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Avian metapneumovirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_162387 .

obo:NCBITaxon_38568
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subgenus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Leishmania"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leishmania <subgenus>"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5658 .

obo:NCBITaxon_38574
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank <http://purl.obolibrary.org/obo/NCBITaxon#_species_group>, obo:NCBITaxon_species_group ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leishmania donovani species complex"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_38568 .

obo:NCBITaxon_39107
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasAlternativeId "NCBITaxon:109679"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Murinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9989 .

obo:NCBITaxon_391902
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subspecies ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bubalus bubalis bubalis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_27592 .

obo:NCBITaxon_393305
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Yersinia enterocolitica subsp. enterocolitica str. 8081"^^xsd:string, "Yersinia enterocolitica subsp. enterocolitica strain 8081"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersinia enterocolitica subsp. enterocolitica 8081"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_150052 .

obo:NCBITaxon_39724
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family .

obo:NCBITaxon_39744
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rubulavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11158 .

obo:NCBITaxon_39944
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "CpHV-1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Caprine herpesvirus 1"^^xsd:string, "Caprine herpesvirus type 1"^^xsd:string, "goat herpesvirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Caprine alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10319 .

obo:NCBITaxon_40050
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:10896"^^xsd:string ;
    oboInOwl:hasBroadSynonym "AHSV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "African horse sickness group"^^xsd:string, "African horse sickness virus (AHSV)"^^xsd:string, "African horsesickness virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "African horse sickness virus AHSV"^^xsd:string ;
    a owl:Class ;
    rdfs:label "African horse sickness virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10892 .

obo:NCBITaxon_40051
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:12591"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bluetongue virus group"^^xsd:string, "bluetongue virus BTV"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bluetongue virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10892 .

obo:NCBITaxon_400570
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Quailpox virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10260 .

obo:NCBITaxon_40119
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Parvovirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732415 .

obo:NCBITaxon_40269
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:18048732"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Vibrio salmonicida"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Aliivibrio salmonicida"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_641 .

obo:NCBITaxon_40674
    obo:IAO_0000111 "Mammalia"^^xsd:string ;
    obo:IAO_0000118 "mammals"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "mammals"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "mammals"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mammalia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_32524 .

obo:NCBITaxon_41678
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasBroadSynonym "TAdV-3"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Marble spleen disease virus"^^xsd:string, "Turkey adenovirus serotype 3"^^xsd:string, "Turkey haemorrhagic enteritis virus"^^xsd:string, "Turkey hemorrhagic enteritis virus"^^xsd:string, "hemorrhagic enteritis virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Turkey adenovirus 3"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10508 .

obo:NCBITaxon_418101
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subgenus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Vinckeia"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Plasmodium (Vinckeia)"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5820 .

obo:NCBITaxon_422676
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Hematozoa Vivier 1982"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Aconoidasida"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5794 .

obo:NCBITaxon_423054
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_suborder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Eimeriorina"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5794 .

obo:NCBITaxon_42890
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Sarcocystis neurona"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5809 .

obo:NCBITaxon_430066
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella abortus str. S19"^^xsd:string, "Brucella abortus strain S19"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella abortus S19"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_235 .

obo:NCBITaxon_439488
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_44088
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "CNPV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Avipoxvirus clade B1"^^xsd:string, "Canary poxvirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canarypox virus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10260 .

obo:NCBITaxon_444163
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:399128"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:18218934"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella microti"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_234 .

obo:NCBITaxon_444178
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella ovis str. ATCC 25840"^^xsd:string, "Brucella ovis strain ATCC 25840"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella ovis ATCC 25840"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_236 .

obo:NCBITaxon_464095
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Picornavirales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732506 .

obo:NCBITaxon_470137
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:19346311"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella suis str. ATCC 23445"^^xsd:string, "Brucella suis strain ATCC 23445"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella suis ATCC 23445"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_29461 .

obo:NCBITaxon_4751
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_kingdom ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:11062127"^^xsd:string, "PMID:12684019"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Mycota"^^xsd:string, "fungi"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Fungi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33154 .

obo:NCBITaxon_483179
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:19346311"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella canis str. ATCC 23365"^^xsd:string, "Brucella canis strain ATCC 23365"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella canis ATCC 23365"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_36855 .

obo:NCBITaxon_487
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Diplokokkus intracellularis meningitidis"^^xsd:string, "Micrococcus intracellularis"^^xsd:string, "Micrococcus meningitidis"^^xsd:string, "Micrococcus meningitidis cerebrospinalis"^^xsd:string, "Neisseria weichselbaumii"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_206351 .

obo:NCBITaxon_49546
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family .

obo:NCBITaxon_50294
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "PsHV-1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Pacheco's disease virus"^^xsd:string, "Psittacid herpesvirus 1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Psittacid alphaherpesvirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_180255 .

obo:NCBITaxon_504568
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "trouts, salmons & chars"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmoninae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_8015 .

obo:NCBITaxon_517
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11491321"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bordetella"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_80840 .

obo:NCBITaxon_518
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:514"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:8240949"^^xsd:string, "PMID:8782670"^^xsd:string, "PMID:9226899"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Alcaligenes bronchicanis"^^xsd:string, "Alcaligenes bronchisepticus"^^xsd:string, "Bacillus bronchicanis"^^xsd:string, "Bacillus bronchisepticus"^^xsd:string, "Bacterium bronchisepticus"^^xsd:string, "Brucella bronchiseptica"^^xsd:string, "Haemophilus bronchisepticus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bordetella bronchiseptica"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_517 .

obo:NCBITaxon_520
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:8240949"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacterium tussis-convulsivae"^^xsd:string, "Haemophilus pertussis"^^xsd:string, "Hemophilus pertussis"^^xsd:string, "Microbe de la coqueluche"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_517 .

obo:NCBITaxon_521
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:4074238"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bordetella avium"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_517 .

obo:NCBITaxon_543
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10555323"^^xsd:string, "PMID:10555334"^^xsd:string, "PMID:16166704"^^xsd:string, "PMID:27620848"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Enterobacteraceae"^^xsd:string, "enterobacteria"^^xsd:string, "gamma-3 proteobacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Enterobacteriaceae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91347 .

obo:NCBITaxon_54315
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasAlternativeId "NCBITaxon:136447"^^xsd:string, "NCBITaxon:64986"^^xsd:string, "NCBITaxon:96055"^^xsd:string ;
    oboInOwl:hasBroadSynonym "BVDV type II"^^xsd:string, "BVDV-2"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:7747470"^^xsd:string ;
    oboInOwl:hasExactSynonym "Bovine viral diarrhea virus genotype 2"^^xsd:string, "Bovine viral diarrhea virus type 2"^^xsd:string, "Bovine viral diarrhea virus-2"^^xsd:string, "bovine viral diarrhea virus type II"^^xsd:string, "pestivirus type 4"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovine viral diarrhea virus 2"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11095 .

obo:NCBITaxon_546272
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:19346311"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella melitensis str. ATCC 23457"^^xsd:string, "Brucella melitensis strain ATCC 23457"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella melitensis ATCC 23457"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_29459 .

obo:NCBITaxon_5500
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Coccidioides"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_4751 .

obo:NCBITaxon_55601
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:28167"^^xsd:string, "NCBITaxon:665"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:21296930"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Achromobacter ichthyodermis"^^xsd:string, "Listonella anguillara"^^xsd:string, "Listonella anguillarum"^^xsd:string, "Pseudomonas ichthyodermis"^^xsd:string, "Vibrio ichthyodermis"^^xsd:string, "Vibrio piscium"^^xsd:string, "Vibrio piscium var. japonicus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Vibrio anguillarum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_662 .

obo:NCBITaxon_55987
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:155284"^^xsd:string, "NCBITaxon:86501"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmon isavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11308 .

obo:NCBITaxon_560210
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Dintheria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_119088 .

obo:NCBITaxon_562
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1637691"^^xsd:string, "NCBITaxon:1806490"^^xsd:string, "NCBITaxon:469598"^^xsd:string, "NCBITaxon:662101"^^xsd:string, "NCBITaxon:662104"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319482"^^xsd:string ;
    oboInOwl:hasExactSynonym "E. coli"^^xsd:string, "Escherichia/Shigella coli"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus coli"^^xsd:string, "Bacterium coli"^^xsd:string, "Bacterium coli commune"^^xsd:string, "Enterococcus coli"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Escherichia coli"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_543 .

obo:NCBITaxon_5654
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Trypanosomatidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2611352 .

obo:NCBITaxon_5658
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Leishmania"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leishmania <genus>"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5654 .

obo:NCBITaxon_5659
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:31284"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leishmania (Leishmania) amazonensis"^^xsd:string, "Leishmania mexicana amazonensis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leishmania amazonensis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_38568 .

obo:NCBITaxon_5661
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leishmania (Leishmania) donovani"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leishmania donovani"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_38574 .

obo:NCBITaxon_5664
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leishmania (Leishmania) major"^^xsd:string, "Leishmania tropica major"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leishmania major"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_38568 .

obo:NCBITaxon_56690
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:33701"^^xsd:string, "NCBITaxon:5724"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:12046599"^^xsd:string, "PMID:15734659"^^xsd:string, "PMID:22000167"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Tritrichomonas suis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2611341, obo:VO_0000333 .

obo:NCBITaxon_5671
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:5662"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Leishmania (Leishmania) infantum"^^xsd:string, "Leishmania donovani infantum"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leishmania infantum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_38574 .

obo:NCBITaxon_568815
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_strain ;
    oboInOwl:hasAlternativeId "NCBITaxon:399127"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:19653890"^^xsd:string ;
    oboInOwl:hasExactSynonym "Brucella microti str. CCM 4915"^^xsd:string, "Brucella microti strain CCM 4915"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Brucella sp. CCM 4915"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Brucella microti CCM 4915"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_444163 .

obo:NCBITaxon_5690
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Trypanosoma"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5654 .

obo:NCBITaxon_5691
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Trypanosoma (Trypanozoon) brucei"^^xsd:string, "Trypanosoma brucei subgroup"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Trypanosoma brucei"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5690 .

obo:NCBITaxon_5693
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Trypanosoma cruzi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5690 .

obo:NCBITaxon_5741
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:11432808"^^xsd:string, "PMID:19135417"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Giardia duodenalis"^^xsd:string, "Giardia lamblia"^^xsd:string, "Lamblia intestinalis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Giardia intestinalis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2611341, obo:VO_0000333 .

obo:NCBITaxon_5759
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Entamoeba histolytica"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2759 .

obo:NCBITaxon_5761
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Naegleria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2611352 .

obo:NCBITaxon_5762
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Naegleria gruberi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5761 .

obo:NCBITaxon_5763
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "brain-eating amoeba"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Naegleria fowleri"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5761 .

obo:NCBITaxon_5794
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_phylum ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "apicomplexans"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "apicomplexans"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Apicomplexa"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2759 .

obo:NCBITaxon_5800
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Eimeria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_423054 .

obo:NCBITaxon_5802
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Eimeria tenella"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5800 .

obo:NCBITaxon_5804
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Eimeria maxima"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5800 .

obo:NCBITaxon_5807
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:2200815"^^xsd:string, "NCBITaxon:2200816"^^xsd:string, "NCBITaxon:2200817"^^xsd:string, "NCBITaxon:2200818"^^xsd:string, "NCBITaxon:2200819"^^xsd:string, "NCBITaxon:2200820"^^xsd:string, "NCBITaxon:2200821"^^xsd:string, "NCBITaxon:2200822"^^xsd:string, "NCBITaxon:2200823"^^xsd:string, "NCBITaxon:2200824"^^xsd:string, "NCBITaxon:2200825"^^xsd:string, "NCBITaxon:2200826"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Cryptosporidium parvum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_423054 .

obo:NCBITaxon_5809
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Sarcocystids"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Sarcocystidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_423054 .

obo:NCBITaxon_5811
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Toxoplasma gondii"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5809 .

obo:NCBITaxon_5820
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Plasmodium"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_422676 .

obo:NCBITaxon_5821
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Plasmodium berghei"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_418101 .

obo:NCBITaxon_5833
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "malaria parasite P. falciparum"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Plasmodium (Laverania) falciparum"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Plasmodium falciparum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5820 .

obo:NCBITaxon_5855
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "malaria parasite P. vivax"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Haemamoeba vivax"^^xsd:string, "Haemamoeba vivax Grassi and Feletti, 1890"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Plasmodium vivax"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5820 .

obo:NCBITaxon_5861
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Plasmodium yoelli"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Plasmodium yoelii"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_418101 .

obo:NCBITaxon_5863
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Piroplasmids"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Piroplasmida"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_422676 .

obo:NCBITaxon_5864
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Babesia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5863 .

obo:NCBITaxon_5865
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Babesia bovis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5864 .

obo:NCBITaxon_5866
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Babesia bigemina"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5864 .

obo:NCBITaxon_5867
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Babesia canis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5864 .

obo:NCBITaxon_5873
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Theileria"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5863 .

obo:NCBITaxon_5874
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Theileria annulata"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5873 .

obo:NCBITaxon_5875
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Theileria parva"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5873 .

obo:NCBITaxon_590
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319519"^^xsd:string, "PMID:10939679"^^xsd:string, "PMID:12072558"^^xsd:string, "PMID:15653929"^^xsd:string, "PMID:15653930"^^xsd:string, "PMID:3231714"^^xsd:string, "PMID:9731304"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmonella"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_543 .

obo:NCBITaxon_59201
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subspecies ;
    oboInOwl:hasAlternativeId "NCBITaxon:149049"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15653929"^^xsd:string, "PMID:15653930"^^xsd:string, "PMID:7149525"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Salmonella cholerae-suis subsp. cholerae-suis"^^xsd:string, "Salmonella choleraesuis subsp. choleraesuis"^^xsd:string, "Salmonella enterica I"^^xsd:string, "Salmonella enterica subsp. I"^^xsd:string, "Salmonella enterica subsp. Subsp. I"^^xsd:string, "Salmonella enterica subsp. Subsp. Ixxx"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmonella enterica subsp. enterica"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_590 .

obo:NCBITaxon_594
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasAlternativeId "NCBITaxon:41510"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Salmonella enterica serovar Gallinarum"^^xsd:string, "Salmonella gallinarum"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmonella enterica subsp. enterica serovar Gallinarum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_59201 .

obo:NCBITaxon_6181
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Schistosoma"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33317 .

obo:NCBITaxon_6182
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Schistosoma japonicum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_6181 .

obo:NCBITaxon_6183
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Schistosoma mansoni"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_6181 .

obo:NCBITaxon_619591
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Monkeypox virus Zaire-96-I-16"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10244 .

obo:NCBITaxon_620
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:26834722"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Shigella"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_543 .

obo:NCBITaxon_622
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:12054222"^^xsd:string ;
    oboInOwl:hasExactSynonym "Escherichia/Shigella dysenteriae"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus dysenteriae"^^xsd:string, "Bacillus dysentericus"^^xsd:string, "Bacillus shigae"^^xsd:string, "Eberthella dysenteriae"^^xsd:string, "Shigella shigae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Shigella dysenteriae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_620 .

obo:NCBITaxon_623
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Escherichia flexneri"^^xsd:string, "Escherichia/Shigella flexneri"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Shigella paradysenteriae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Shigella flexneri"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_620 .

obo:NCBITaxon_624
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacterium sonnei"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Shigella sonnei"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_620 .

obo:NCBITaxon_629
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Yersinia"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersinia <enterobacteria>"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1903411 .

obo:NCBITaxon_632
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15084509"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus pestis"^^xsd:string, "Bacterium pestis"^^xsd:string, "Pasteurella pestis"^^xsd:string, "Pestisella pestis"^^xsd:string, "Yersinia pseudotuberculosis subsp. pestis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersinia pestis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1649845 .

obo:NCBITaxon_633
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1161941"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:2223608"^^xsd:string, "PMID:23919959"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus pseudotuberkulosis"^^xsd:string, "Bacterium pseudotuberculosis"^^xsd:string, "Pasteurella lymphangitidis"^^xsd:string, "Pasteurella pseudotuberculosis"^^xsd:string, "Shigella pseudotuberculosis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Yersinia pseudotuberculosis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1649845 .

obo:NCBITaxon_63330
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:45337"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:7701348"^^xsd:string ;
    oboInOwl:hasExactSynonym "Equine morbillivirus"^^xsd:string, "Hendra virus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Hendra henipavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_260964 .

obo:NCBITaxon_6334
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Trichinella spiralis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_119088 .

obo:NCBITaxon_635
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasExactSynonym "Edwardsiella"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Asakusa group"^^xsd:string, "Bartholomew group"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Edwardsiella <enterobacteria>"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91347 .

obo:NCBITaxon_636
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1471792"^^xsd:string, "NCBITaxon:1471793"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:27539016"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Edwardsiella anguillimortifera"^^xsd:string, "Paracolobactrum anguillimortiferum"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Edwardsiella tarda"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_635 .

obo:NCBITaxon_641
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15143042"^^xsd:string, "PMID:4954820"^^xsd:string, "PMID:8427811"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "gamma-3 proteobacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Vibrionaceae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1236 .

obo:NCBITaxon_642
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11155981"^^xsd:string, "PMID:12067377"^^xsd:string, "PMID:12807216"^^xsd:string, "PMID:1380286"^^xsd:string, "PMID:1380289"^^xsd:string, "PMID:15388703"^^xsd:string, "PMID:16560691"^^xsd:string, "PMID:17012583"^^xsd:string, "PMID:17158971"^^xsd:string, "PMID:19567585"^^xsd:string, "PMID:7520733"^^xsd:string, "PMID:8347521"^^xsd:string, "PMID:8934910"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Aeromonas"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1236 .

obo:NCBITaxon_644
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1471787"^^xsd:string, "NCBITaxon:1471788"^^xsd:string, "NCBITaxon:329135"^^xsd:string, "NCBITaxon:329140"^^xsd:string, "NCBITaxon:346633"^^xsd:string, "NCBITaxon:346634"^^xsd:string, "NCBITaxon:582196"^^xsd:string, "NCBITaxon:582198"^^xsd:string, "NCBITaxon:582214"^^xsd:string, "NCBITaxon:582215"^^xsd:string, "NCBITaxon:582216"^^xsd:string, "NCBITaxon:582217"^^xsd:string, "NCBITaxon:582218"^^xsd:string, "NCBITaxon:582219"^^xsd:string, "NCBITaxon:582220"^^xsd:string, "NCBITaxon:582221"^^xsd:string, "NCBITaxon:582222"^^xsd:string, "NCBITaxon:582223"^^xsd:string, "NCBITaxon:582224"^^xsd:string, "NCBITaxon:582225"^^xsd:string, "NCBITaxon:582226"^^xsd:string, "NCBITaxon:582228"^^xsd:string, "NCBITaxon:582229"^^xsd:string, "NCBITaxon:582231"^^xsd:string, "NCBITaxon:582236"^^xsd:string, "NCBITaxon:582237"^^xsd:string, "NCBITaxon:582240"^^xsd:string, "NCBITaxon:582250"^^xsd:string, "NCBITaxon:582251"^^xsd:string, "NCBITaxon:582253"^^xsd:string, "NCBITaxon:582254"^^xsd:string, "NCBITaxon:582265"^^xsd:string, "NCBITaxon:582266"^^xsd:string, "NCBITaxon:582267"^^xsd:string, "NCBITaxon:582279"^^xsd:string, "NCBITaxon:582282"^^xsd:string, "NCBITaxon:582284"^^xsd:string, "NCBITaxon:582286"^^xsd:string, "NCBITaxon:582287"^^xsd:string, "NCBITaxon:582289"^^xsd:string, "NCBITaxon:582290"^^xsd:string, "NCBITaxon:582291"^^xsd:string, "NCBITaxon:582292"^^xsd:string, "NCBITaxon:582295"^^xsd:string, "NCBITaxon:582297"^^xsd:string, "NCBITaxon:582299"^^xsd:string, "NCBITaxon:582300"^^xsd:string, "NCBITaxon:582302"^^xsd:string, "NCBITaxon:582303"^^xsd:string, "NCBITaxon:582304"^^xsd:string, "NCBITaxon:582305"^^xsd:string, "NCBITaxon:582306"^^xsd:string, "NCBITaxon:582307"^^xsd:string, "NCBITaxon:582308"^^xsd:string, "NCBITaxon:582309"^^xsd:string, "NCBITaxon:582310"^^xsd:string, "NCBITaxon:582311"^^xsd:string, "NCBITaxon:582312"^^xsd:string, "NCBITaxon:582313"^^xsd:string, "NCBITaxon:582314"^^xsd:string, "NCBITaxon:582315"^^xsd:string, "NCBITaxon:582316"^^xsd:string, "NCBITaxon:582317"^^xsd:string, "NCBITaxon:582318"^^xsd:string, "NCBITaxon:582319"^^xsd:string, "NCBITaxon:582320"^^xsd:string, "NCBITaxon:582321"^^xsd:string, "NCBITaxon:582322"^^xsd:string, "NCBITaxon:582323"^^xsd:string, "NCBITaxon:582324"^^xsd:string, "NCBITaxon:98358"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:16560691"^^xsd:string, "PMID:19965992"^^xsd:string, "PMID:23485124"^^xsd:string, "PMID:932684"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Aeromonas dourgesi"^^xsd:string, "Aeromonas liquefaciens"^^xsd:string, "Bacillus hydrophilus"^^xsd:string, "Bacillus hydrophilus fuscus"^^xsd:string, "Bacterium hydrophilum"^^xsd:string, "Proteus hydrophilus"^^xsd:string, "Proteus ichthyosmius"^^xsd:string, "Pseudomonas hydrophila"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Aeromonas hydrophila"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_642 .

obo:NCBITaxon_645
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1055664"^^xsd:string, "NCBITaxon:697046"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:19965992"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus salmonicida"^^xsd:string, "Bacterium salmonicida"^^xsd:string, "Proteus salmonicida"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Aeromonas salmonicida"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_642 .

obo:NCBITaxon_64895
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:1618316"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10515907"^^xsd:string, "PMID:10758897"^^xsd:string, "PMID:16585709"^^xsd:string, "PMID:24744012"^^xsd:string, "PMID:27930271"^^xsd:string, "PMID:28141502"^^xsd:string, "PMID:30154058"^^xsd:string, "PMID:30586413"^^xsd:string, "PMID:31454394"^^xsd:string, "PMID:31722850"^^xsd:string, "PMID:31836459"^^xsd:string, "PMID:32320380"^^xsd:string, "PMID:7981102"^^xsd:string, "PMID:8573491"^^xsd:string, "PMID:8934900"^^xsd:string, "PMID:8995795"^^xsd:string, "PMID:9336916"^^xsd:string ;
    oboInOwl:hasExactSynonym "Lyme Disease Borrelia"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Borrelia burgdorferi group"^^xsd:string, "Borrelia burgdorferi sensu lato"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Borreliella"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_136 .

obo:NCBITaxon_662
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:705"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1371064"^^xsd:string, "PMID:17978204"^^xsd:string, "PMID:21057054"^^xsd:string, "PMID:21296930"^^xsd:string, "PMID:24409173"^^xsd:string, "PMID:4935323"^^xsd:string, "PMID:7520733"^^xsd:string, "PMID:8590667"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Beneckea"^^xsd:string, "Listonella"^^xsd:string, "Microspira"^^xsd:string, "Pacinia"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Vibrio"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_641 .

obo:NCBITaxon_666
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:140100"^^xsd:string, "NCBITaxon:376726"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1015934"^^xsd:string, "PMID:9272984"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillo virgola del Koch"^^xsd:string, "Bacillus cholerae"^^xsd:string, "Bacillus cholerae-asiaticae"^^xsd:string, "Kommabacillus"^^xsd:string, "Liquidivibrio cholerae"^^xsd:string, "Microspira comma"^^xsd:string, "Pacinia cholerae-asiaticae"^^xsd:string, "Spirillum cholerae"^^xsd:string, "Spirillum cholerae-asiaticae"^^xsd:string, "Vibrio albensis"^^xsd:string, "Vibrio cholera"^^xsd:string, "Vibrio cholerae biovar albensis"^^xsd:string, "Vibrio cholerae bv. albensis"^^xsd:string, "Vibrio cholerae-asiaticae"^^xsd:string, "Vibrio comma"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Vibrio cholerae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_662 .

obo:NCBITaxon_67780
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Edwardsiella ictaluri"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_635 .

obo:NCBITaxon_68525
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subphylum ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11837318"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "delta/epsilon subdivisions"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1224 .

obo:NCBITaxon_689832
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Sedoreovirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_10880 .

obo:NCBITaxon_691956
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:352473"^^xsd:string ;
    oboInOwl:hasBroadSynonym "DHV-1"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Duck hepatitis A virus"^^xsd:string, "Duck hepatitis virus 1"^^xsd:string, "Duck hepatitis virus type 1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Avihepatovirus A"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12058 .

obo:NCBITaxon_693995
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Coronavirinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_11118 .

obo:NCBITaxon_693997
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Alphacoronavirus-1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Alphacoronavirus 1"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2501931 .

obo:NCBITaxon_694002
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:156439"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Coronavirus group 2"^^xsd:string, "Group 2 species"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Coronavirus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Betacoronavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2501931 .

obo:NCBITaxon_694009
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:227859"^^xsd:string, "NCBITaxon:311178"^^xsd:string ;
    oboInOwl:hasBroadSynonym "HCoV-SARS"^^xsd:string, "SARS"^^xsd:string, "SARSr-CoV"^^xsd:string, "SARSrCoV"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Human coronavirus (strain SARS)"^^xsd:string, "SARS-like coronavirus"^^xsd:string, "SARS-related coronavirus"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Severe acute respiratory syndrome-related coronavirus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_694002 .

obo:NCBITaxon_70796
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Tremovirus A"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_12058 .

obo:NCBITaxon_712
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10843050"^^xsd:string, "PMID:15280320"^^xsd:string, "PMID:15388716"^^xsd:string, "PMID:17220461"^^xsd:string, "PMID:2223605"^^xsd:string, "PMID:29923825"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pasteurellaceae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1236 .

obo:NCBITaxon_715
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1847295"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Haemophilus pleuropneumoniae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Actinobacillus pleuropneumoniae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_712 .

obo:NCBITaxon_72273
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Thiomicrospira group"^^xsd:string, "Thiothrix/Francisella group"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Thiotrichales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1236 .

obo:NCBITaxon_724
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:1736960"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Haemophilus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_712 .

obo:NCBITaxon_727
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacterium influenzae"^^xsd:string, "Coccobacillus pfeifferi"^^xsd:string, "Haemophilus meningitidis"^^xsd:string, "Influenza-bacillus"^^xsd:string, "Mycobacterium influenzae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_724 .

obo:NCBITaxon_731
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:163489"^^xsd:string, "NCBITaxon:214923"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:13130032"^^xsd:string, "PMID:4333932"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Haemophilus agni"^^xsd:string, "Haemophilus ovis"^^xsd:string, "Haemophilus somnifer"^^xsd:string, "Haemophilus somnus"^^xsd:string, "Hemophilus agni"^^xsd:string, "Histophilus ovis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Histophilus somni"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_712 .

obo:NCBITaxon_738
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:31592757"^^xsd:string, "PMID:5821848"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Haemophilus parasuis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Glaesserella parasuis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_712 .

obo:NCBITaxon_747
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15184562"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacterium multocidum"^^xsd:string, "Micrococcus gallicidus"^^xsd:string, "Pasteurella cholerae-gallinarum"^^xsd:string, "Pasteurella gallicida"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Pasteurella multocida"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_712 .

obo:NCBITaxon_75985
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:746"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10028248"^^xsd:string, "PMID:8782683"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Pasteurella haemolytica"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mannheimia haemolytica"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_712 .

obo:NCBITaxon_766
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11760958"^^xsd:string, "PMID:8240958"^^xsd:string ;
    oboInOwl:hasExactSynonym "rickettsias"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "alpha-1 proteobacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rickettsiales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_28211 .

obo:NCBITaxon_76803
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Arteriviridae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_76804 .

obo:NCBITaxon_76804
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Nidovirales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732506 .

obo:NCBITaxon_77054
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:61430"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Theileria hirci"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Theileria lestoquardi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_5873 .

obo:NCBITaxon_7742
    obo:IAO_0000111 "Vertebrata <vertebrates>"^^xsd:string ;
    obo:IAO_0000118 "Vertebrata"^^xsd:string, "vertebrates"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_clade ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Vertebrata"^^xsd:string, "vertebrates"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "vertebrates"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Vertebrata <vertebrates>"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33213 .

obo:NCBITaxon_777
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:9226923"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Rickettsia burneti"^^xsd:string, "Rickettsia diaporica"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Coxiella burnetii"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1236 .

obo:NCBITaxon_780
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10939649"^^xsd:string, "PMID:11491333"^^xsd:string, "PMID:14662925"^^xsd:string, "PMID:9103608"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rickettsia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_766 .

obo:NCBITaxon_7898
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class, obo:NCBITaxon_superclass ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "fish"^^xsd:string, "fishes"^^xsd:string, "ray-finned fishes"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Actinopterygi"^^xsd:string, "Osteichthyes"^^xsd:string, "bony fishes"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Actinopterygii"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_117571 .

obo:NCBITaxon_79668
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Clostridium perfringens C"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1502 .

obo:NCBITaxon_7995
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "catfishes"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Siluriformes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_186625 .

obo:NCBITaxon_8015
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:15062801"^^xsd:string ;
    oboInOwl:hasExactSynonym "salmonids"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmonidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1489388 .

obo:NCBITaxon_8022
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:1311475"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "rainbow trout"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Oncorhynchus nerka mykiss"^^xsd:string, "Parasalmo mykiss"^^xsd:string, "Salmo mykiss"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Oncorhynchus mykiss"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_504568 .

obo:NCBITaxon_80840
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:16403855"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Burkholderia/Oxalobacter/Ralstonia group"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Burkholderiales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_28216 .

obo:NCBITaxon_810
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:83553"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319462"^^xsd:string, "PMID:11211265"^^xsd:string, "PMID:21048221"^^xsd:string, "PMID:21048222"^^xsd:string, "PMID:23620152"^^xsd:string, "PMID:25618261"^^xsd:string, "PMID:9103632"^^xsd:string, "PMID:9103637"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "\"Prowazekia\" Coles 1953"^^xsd:string, "Bedsonia"^^xsd:string, "Chlamydophila"^^xsd:string, "Miyagawanella"^^xsd:string, "Rakeia"^^xsd:string, "Rickettsiaformis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chlamydia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2 .

obo:NCBITaxon_813
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10192388"^^xsd:string, "PMID:10319462"^^xsd:string, "PMID:8102247"^^xsd:string, "PMID:8347519"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Chlamydozoon trachomatis"^^xsd:string, "Rickettsia trachomae"^^xsd:string, "Rickettsia trachomatis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chlamydia trachomatis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_810 .

obo:NCBITaxon_83332
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/ogg.owl> .

obo:NCBITaxon_83334
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_serotype ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Escherichia coli O157:H7"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_562 .

obo:NCBITaxon_83554
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:812"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319462"^^xsd:string, "PMID:12807198"^^xsd:string, "PMID:8102247"^^xsd:string, "PMID:8347519"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Chlamydophila psittaci"^^xsd:string, "Chlamydozoon psittaci"^^xsd:string, "Ehrlichia psittaci"^^xsd:string, "Rickettsia psittaci"^^xsd:string, "Rickettsiaformis psittacosis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chlamydia psittaci"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_810 .

obo:NCBITaxon_83555
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319462"^^xsd:string, "PMID:12807198"^^xsd:string, "PMID:25618261"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Chlamydia psittaci (Lillie 1930) Page 1968"^^xsd:string, "Chlamydia psittaci serotype 1"^^xsd:string, "Chlamydophila abortus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chlamydia abortus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_810 .

obo:NCBITaxon_83558
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:811"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319462"^^xsd:string, "PMID:8102247"^^xsd:string, "PMID:8347519"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Chlamydophila pneumoniae"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chlamydia pneumoniae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_810 .

obo:NCBITaxon_83560
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319462"^^xsd:string ;
    oboInOwl:hasExactSynonym "agent of mouse pneumonitis"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Chlamydia trachomatis MoPn"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chlamydia muridarum"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_810 .

obo:NCBITaxon_836
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:15774632"^^xsd:string, "PMID:24158948"^^xsd:string, "PMID:25481042"^^xsd:string, "PMID:8186083"^^xsd:string, "PMID:8590687"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Porphyromonas"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_976 .

obo:NCBITaxon_85007
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order, obo:NCBITaxon_suborder ;
    oboInOwl:hasAlternativeId "NCBITaxon:1761"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11837321"^^xsd:string, "PMID:1736962"^^xsd:string, "PMID:19244447"^^xsd:string, "PMID:30186281"^^xsd:string, "PMID:31157615"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Corynebacterineae"^^xsd:string, "Mycobacteriales"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Corynebacteriales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1783272 .

obo:NCBITaxon_85708
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasBroadSynonym "PCV2"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Porcine circovirus Type II"^^xsd:string, "Porcine circovirus type 2"^^xsd:string, "Porcine circovirus-2"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Porcine circovirus 2"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2732092 .

obo:NCBITaxon_8782
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "birds"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "avian"^^xsd:string, "birds"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Aves"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_32561 .

obo:NCBITaxon_8825
    obo:IAO_0000111 "Birds" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_infraclass, obo:NCBITaxon_superorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Neognathae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_8782 .

obo:NCBITaxon_8835
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "ducks"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Anas"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1549675 .

obo:NCBITaxon_89593
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subphylum .

obo:NCBITaxon_9005
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasAlternativeId "NCBITaxon:9099"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "turkeys"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Phasianidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1549675 .

obo:NCBITaxon_90062
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leptospira interrogans serovar Icterohaemorrhagiae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_173 .

obo:NCBITaxon_9031
    obo:IAO_0000116 "chicken" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "Gallus domesticus"^^xsd:string, "bantam"^^xsd:string, "chicken", "chickens"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Gallus gallus domesticus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Gallus gallus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9005 .

obo:NCBITaxon_90370
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasAlternativeId "NCBITaxon:41530"^^xsd:string, "NCBITaxon:601"^^xsd:string, "NCBITaxon:72667"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10319519"^^xsd:string, "PMID:10758910"^^xsd:string, "PMID:15653930"^^xsd:string, "PMID:16558776"^^xsd:string, "PMID:9336938"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus typhi"^^xsd:string, "Bacterium (subgen. Eberthella) typhi"^^xsd:string, "Salmonella choleraesuis serovar Typhi"^^xsd:string, "Salmonella choleraesuis typhi"^^xsd:string, "Salmonella enterica ser. typhi"^^xsd:string, "Salmonella enterica serotype Typhi"^^xsd:string, "Salmonella enterica serovar Typhi"^^xsd:string, "Salmonella typhi"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmonella enterica subsp. enterica serovar Typhi"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_59201 .

obo:NCBITaxon_90371
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    oboInOwl:hasAlternativeId "NCBITaxon:41532"^^xsd:string, "NCBITaxon:59210"^^xsd:string, "NCBITaxon:602"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:10758910"^^xsd:string, "PMID:15653930"^^xsd:string, "PMID:9336938"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus typhimurium"^^xsd:string, "Salmonella choleraesuis serotype typhimurium"^^xsd:string, "Salmonella enterica 1,4,[5],12,:i:1,2"^^xsd:string, "Salmonella enterica ser. typhimurium"^^xsd:string, "Salmonella enterica serotype Typhimurium"^^xsd:string, "Salmonella enterica serovar Typhimurium"^^xsd:string, "Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:1,2"^^xsd:string, "Salmonella typhi-murium"^^xsd:string, "Salmonella typhimurium"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Salmonella enterica subsp. enterica serovar Typhimurium"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_59201 .

obo:NCBITaxon_9103
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "common turkey"^^xsd:string, "turkey"^^xsd:string, "wild turkey"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Meleagris gallopavo"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9005 .

obo:NCBITaxon_91061
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_class ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus/Lactobacillus/Streptococcus group"^^xsd:string, "Firmibacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bacilli"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1239 .

obo:NCBITaxon_91347
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:27620848"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Enterobacteriaceae and related endosymbionts"^^xsd:string, "Enterobacteriaceae group"^^xsd:string, "Enterobacteriales"^^xsd:string, "gamma-3 proteobacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Enterobacterales"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_1236 .

obo:NCBITaxon_91561
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "whales, hippos, ruminants, pigs, camels etc."^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Cetartiodactyla"^^xsd:string, "even-toed ungulates"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Artiodactyla"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314145 .

obo:NCBITaxon_9224
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "parrot"^^xsd:string, "parrots"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Psittacidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_8825 .

obo:NCBITaxon_9347
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> .

obo:NCBITaxon_94063
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Leptospira sp. Pomona"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_171 .

obo:NCBITaxon_9479
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_parvorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "New World monkeys"^^xsd:string, "monkey"^^xsd:string, "monkeys"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Platyrrhini"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314293 .

obo:NCBITaxon_950
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11760958"^^xsd:string, "PMID:1736961"^^xsd:string, "PMID:7537065"^^xsd:string ;
    oboInOwl:hasExactSynonym "Potomac horse fever agent"^^xsd:string, "equine monocytic ehrlichiosis agent"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Ehrlichia risticii"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Neorickettsia risticii"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_766 .

obo:NCBITaxon_9526
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_parvorder ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Catarrhini"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314293 .

obo:NCBITaxon_9534
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "African green monkey"^^xsd:string, "African green monkeys"^^xsd:string, "grivet"^^xsd:string, "savanah monkey"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Ceropithecus aethiops"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Chlorocebus aethiops"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9526 .

obo:NCBITaxon_9606
    obo:IAO_0000111 "Homo sapiens"^^xsd:string ;
    obo:IAO_0000118 "human"^^xsd:string, "human being"^^xsd:string, "man"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl>, <http://purl.obolibrary.org/obo/obi.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "human"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Homo sapiens"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314146, obo:NCBITaxon_9526 .

obo:NCBITaxon_9608
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "dog, coyote, wolf, fox"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_379584 .

obo:NCBITaxon_9611
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9608 .

obo:NCBITaxon_9612
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "gray wolf"^^xsd:string, "grey wolf"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canis lupus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9611 .

obo:NCBITaxon_9615
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subspecies ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "dog"^^xsd:string, "dogs"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Canis canis"^^xsd:string, "Canis domesticus"^^xsd:string, "Canis familiaris"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Canis lupus familiaris"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9612 .

obo:NCBITaxon_9625
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasAlternativeId "NCBITaxon:68731"^^xsd:string, "NCBITaxon:9609"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Fennecus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Vulpes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9608 .

obo:NCBITaxon_9654
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "northern raccoon"^^xsd:string, "raccoon"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Procyon lotor"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_379584 .

obo:NCBITaxon_9669
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subspecies ;
    oboInOwl:hasAlternativeId "NCBITaxon:77150"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "black ferret"^^xsd:string, "domestic ferret"^^xsd:string, "ferret"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Mustela furo"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Mustela putorius furo"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_379584 .

obo:NCBITaxon_9682
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Felis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_33554 .

obo:NCBITaxon_9685
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:36475"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string, "PMID:17600185"^^xsd:string, "PMID:8581300"^^xsd:string, "PMID:8603894"^^xsd:string ;
    oboInOwl:hasExactSynonym "cat"^^xsd:string, "cats"^^xsd:string, "domestic cat"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Felis domesticus"^^xsd:string, "Felis silvestris catus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Felis catus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9682 .

obo:NCBITaxon_976
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_phylum ;
    oboInOwl:hasAlternativeId "NCBITaxon:171554"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11541229"^^xsd:string, "PMID:11542017"^^xsd:string, "PMID:26654112"^^xsd:string, "PMID:28066339"^^xsd:string, "PMID:29458499"^^xsd:string ;
    oboInOwl:hasExactSynonym "BCF group"^^xsd:string, "Bacteroides-Cytophaga-Flexibacter group"^^xsd:string, "CFB group"^^xsd:string, "Cytophaga-Flexibacter-Bacteroides phylum"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacteroidaeota"^^xsd:string, "Bacteroidota"^^xsd:string, "CFB group bacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bacteroidetes"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_2 .

obo:NCBITaxon_9768
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "sei whale"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Balaenoptera borealis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91561 .

obo:NCBITaxon_9788
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "horses"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Equidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314145 .

obo:NCBITaxon_9796
    obo:IAO_0000116 "horse" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "domestic horse"^^xsd:string, "equine"^^xsd:string, "horse" ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Equus przewalskii f. caballus"^^xsd:string, "Equus przewalskii forma caballus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Equus caballus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9788 .

obo:NCBITaxon_9823
    obo:IAO_0000116 "pig" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "pig", "pigs"^^xsd:string, "swine"^^xsd:string, "wild boar"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Sus scrofa"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_91561 .

obo:NCBITaxon_9850
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "deer"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Cervidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_35500 .

obo:NCBITaxon_9895
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_family ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bovidae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_35500 .

obo:NCBITaxon_9900
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bison"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_27592 .

obo:NCBITaxon_9901
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "American bison"^^xsd:string, "Bison"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bos (Bison) bison"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bison bison"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9900 .

obo:NCBITaxon_9913
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:272461"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "bovine"^^xsd:string, "cattle"^^xsd:string, "cow"^^xsd:string, "dairy cow"^^xsd:string, "domestic cattle"^^xsd:string, "domestic cow"^^xsd:string, "ox"^^xsd:string, "oxen"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bos bovis"^^xsd:string, "Bos primigenius taurus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Bos taurus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_27592 .

obo:NCBITaxon_9925
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:57076"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "domestic goat"^^xsd:string, "goat"^^xsd:string, "goats"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Capra aegagrus hircus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Capra hircus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9963 .

obo:NCBITaxon_9935
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_genus ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Ovis"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9963 .

obo:NCBITaxon_9940
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:9936"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "domestic sheep"^^xsd:string, "lambs"^^xsd:string, "sheep"^^xsd:string, "wild sheep"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Ovis ammon aries"^^xsd:string, "Ovis orientalis aries"^^xsd:string, "Ovis ovis"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Ovis aries"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9935 .

obo:NCBITaxon_996
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:29531"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:11"^^xsd:string, "PMID:11594628"^^xsd:string, "PMID:16560903"^^xsd:string, "PMID:29593693"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Bacillus columnaris"^^xsd:string, "Chondrococcus columnaris"^^xsd:string, "Cytophaga columnaris"^^xsd:string, "Flexibacter columnaris"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Flavobacterium columnare"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_200644 .

obo:NCBITaxon_9963
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_subfamily ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Caprinae"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_9895 .

obo:NCBITaxon_9986
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_species ;
    oboInOwl:hasAlternativeId "NCBITaxon:34833"^^xsd:string, "NCBITaxon:9985"^^xsd:string ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "European rabbit"^^xsd:string, "Japanese white rabbit"^^xsd:string, "domestic rabbit"^^xsd:string, "rabbit"^^xsd:string, "rabbits"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Lepus cuniculus"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Oryctolagus cuniculus"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314147 .

obo:NCBITaxon_9989
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ncbitaxon.owl> ;
    ncbitaxon:has_rank obo:NCBITaxon_order ;
    oboInOwl:hasDbXref "GC_ID:1"^^xsd:string ;
    oboInOwl:hasExactSynonym "rodent"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "rodents"^^xsd:string ;
    a owl:Class ;
    rdfs:label "Rodentia"^^xsd:string ;
    rdfs:subClassOf obo:NCBITaxon_314147 .

obo:OAE_0000001
    obo:IAO_0000115 "a pathological bodily process that occurs after a medical intervention." ;
    obo:IAO_0000116 "Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.", "YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.", "YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.", "YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.", "YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "AE", "adverse reaction" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Adverse_event", "WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> ;
    a owl:Class ;
    rdfs:comment "The OAE official website is: http://www.oae-ontology.org/." ;
    rdfs:label "adverse event" ;
    rdfs:subClassOf obo:OGMS_0000061 .

obo:OAE_0000004
    obo:IAO_0000115 "an adverse event that occurs after a vaccination." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> ;
    a owl:Class ;
    rdfs:comment "More specific representation of various vaccine adverse events is seen in the Ontology of Vaccine Adverse Events (OVAE): http://www.violinet.org/ovae/." ;
    rdfs:label "vaccine adverse event" ;
    rdfs:subClassOf obo:OAE_0000001 .

obo:OAE_0000027
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000030
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000034
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000055
    obo:IAO_0000115 "A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment." ;
    obo:IAO_0000117 "Yongqun He, Sirarat Sarntivijai,  Mathias Brochhausen,  William Hogan, ‎Philip E. Empey" ;
    obo:IAO_0000119 "http://en.wikipedia.org/wiki/Contraindication" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> ;
    a owl:Class ;
    rdfs:label "contraindication" ;
    rdfs:subClassOf obo:BFO_0000016 .

obo:OAE_0000073
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000074
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000077
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000085
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000097
    obo:IAO_0000115 "an adverse event that is induced by a vaccination." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> ;
    a owl:Class ;
    rdfs:label "vaccine-induced adverse event" ;
    rdfs:subClassOf obo:OAE_0000004 .

obo:OAE_0000199
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000215
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000216
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000217
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000226
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000306
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000323
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000324
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000325
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000326
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000327
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000331
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000333
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000334
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000335
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000336
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000340
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000343
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000344
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000350
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000351
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000358
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000361
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000362
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000363
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000366
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000368
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000369
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000372
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000373
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000374
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000375
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000376
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000377
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000378
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000381
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000382
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000383
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000385
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000388
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000390
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000391
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000393
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000394
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000396
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000398
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000400
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000402
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000419
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000427
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000434
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000435
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000439
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000442
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000455
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000465
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000476
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000493
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000538
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000546
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000551
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000554
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000555
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000556
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000557
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000564
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000565
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000571
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000574
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000580
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000581
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000582
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000584
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000600
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000601
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000603
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000616
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000624
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000630
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000639
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000643
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000644
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000645
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000650
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0000770
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001105
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001139
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001403
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001546
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001547
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001548
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001549
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OAE_0001550
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl> .

obo:OBI_0000011
    obo:IAO_0000111 "planned process"^^xsd:string, "planned process"@en ;
    obo:IAO_0000112 "Injecting mice with a vaccine in order to test its efficacy"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A process that realizes a plan which is the concretization of a plan specification."@en ;
    obo:IAO_0000116 "'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)"^^xsd:string, """We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some 
objectives is a planned process."""^^xsd:string ;
    obo:IAO_0000117 "Bjoern Peters"^^xsd:string ;
    obo:IAO_0000119 "branch derived"^^xsd:string ;
    obo:IAO_0000232 "6/11/9: Edited at workshop. Used to include: is initiated by an agent"^^xsd:string, "This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call)"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "planned process"@en ;
    rdfs:subClassOf obo:BFO_0000015 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom [
            a owl:Restriction ;
            owl:onProperty obo:RO_0000059 ;
            owl:someValuesFrom obo:IAO_0000104
        ]
    ] .

obo:OBI_0000014
    obo:IAO_0000111 "regulator role"^^xsd:string ;
    obo:IAO_0000112 "Fact sheet - Regulating the companies The role of the regulator. Ofwat is the economic regulator of the water and sewerage industry in England and Wales.  http://www.ofwat.gov.uk/aptrix/ofwat/publish.nsf/Content/roleofregulator_factsheet170805"@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "a regulatory role involved with making and/or enforcing relevant legislation and governmental orders"@en ;
    obo:IAO_0000117 "Person:Jennifer Fostel"@en ;
    obo:IAO_0000118 "regulator"^^xsd:string ;
    obo:IAO_0000119 "OBI"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "regulator role"@en ;
    rdfs:subClassOf obo:OBI_0000017 .

obo:OBI_0000016
    obo:IAO_0000111 "regulation-assigned role"@en ;
    obo:IAO_0000112 "Approval letter"@en ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "Regulation-assigned role is a regulatory role defined by legislation or governmental orders"@en ;
    obo:IAO_0000117 "Person: Jennifer Fostel"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "regulation-assigned role"@en ;
    rdfs:subClassOf obo:OBI_0000017 .

obo:OBI_0000017
    obo:IAO_0000111 "regulatory role"@en ;
    obo:IAO_0000112 "Regulatory agency, Ethics committee, Approval letter; example:  Browse these EPA Regulatory Role subtopics  http://www.epa.gov/ebtpages/enviregulatoryrole.html  Feb 29, 2008"@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body."@en ;
    obo:IAO_0000117 "GROUP:  Role branch"@en ;
    obo:IAO_0000119 "OBI, CDISC"@en ;
    obo:IAO_0000232 "govt agents responsible for creating regulations; proxies for enforcing regulations.  CDISC definition:  regulatory authorities. Bodies having the power to regulate. NOTE: In the ICH GCP guideline the term includes the authorities that review submitted clinical data and those that conduct inspections. These bodies are sometimes referred to as competent"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "regulatory role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000047
    obo:IAO_0000111 "processed material"@en ;
    obo:IAO_0000112 "Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "Is a material entity that is created or changed during material processing."@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "processed material"@en ;
    rdfs:subClassOf obo:BFO_0000040 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:BFO_0000040
            [
                a owl:Restriction ;
                owl:onProperty obo:OBI_0000312 ;
                owl:someValuesFrom obo:OBI_0000094
            ]
        )
    ] .

obo:OBI_0000067
    obo:IAO_0000111 "evaluant role"@en ;
    obo:IAO_0000112 "When a specimen of blood is assayed for glucose concentration, the blood has the evaluant role. When measuring the mass of a mouse, the evaluant is the mouse. When measuring the time of DNA replication, the evaluant is the DNA. When measuring the intensity of light on a surface, the evaluant is the light source."@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role"@en ;
    obo:IAO_0000116 "Role call - 17nov-08: JF and MC think an evaluant role is always specified input of a process. Even in the case where we have an assay taking blood as evaluant and outputting blood, the blood is not the specified output at the end of the assay (the concentration of glucose in the blood is)"@en, "examples of features that could be described in an evaluant: quality.... e.g. \"contains 10 pg/ml IL2\", or \"no glucose detected\")"@en ;
    obo:IAO_0000117 "GROUP:  Role Branch"^^xsd:string ;
    obo:IAO_0000119 "OBI"^^xsd:string ;
    obo:IAO_0000232 "Feb 10, 2009.  changes after discussion at OBI Consortium Workshop Feb 2-6, 2009.  accepted as core term."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "evaluant role"@en ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom obo:BFO_0000040
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:OBI_0000070 ;
        owl:onProperty obo:BFO_0000054
    ] .

obo:OBI_0000070
    obo:IAO_0000111 "assay"@en ;
    obo:IAO_0000112 "Assay the wavelength of light emitted by excited Neon atoms. Count of geese flying over a house."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies."@en ;
    obo:IAO_0000116 "12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation. " ;
    obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ;
    obo:IAO_0000118 "measuring"@en, "scientific observation"@en ;
    obo:IAO_0000119 "OBI branch derived"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    obo:OBI_0001847 "study assay"^^xsd:string ;
    obo:OBI_9991118 "any method"^^xsd:string ;
    a owl:Class ;
    rdfs:label "assay"@en ;
    rdfs:subClassOf obo:OBI_0000011, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom obo:OBI_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:BFO_0000040
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:OBI_0000067
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:IAO_0000027
                [
                    a owl:Restriction ;
                    owl:onProperty obo:IAO_0000136 ;
                    owl:someValuesFrom [
                        a owl:Class ;
                        owl:intersectionOf (obo:BFO_0000040
                            [
                                a owl:Restriction ;
                                owl:onProperty obo:RO_0000087 ;
                                owl:someValuesFrom obo:OBI_0000067
                            ]
                        )
                    ]
                ]
            )
        ]
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000441
    ] .

obo:OBI_0000086
    obo:IAO_0000111 "reagent role"^^xsd:string ;
    obo:IAO_0000112 "Buffer, dye, a catalyst, a solvating agent."@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer."@en ;
    obo:IAO_0000117 "PERSON:Matthew Brush"@en ;
    obo:IAO_0000118 "reagent"^^xsd:string ;
    obo:IAO_0000119 "PERSON:Matthew Brush"^^xsd:string ;
    obo:IAO_0000232 """Feb 10, 2009.  changes after discussion at OBI Consortium Workshop Feb 2-6, 2009.  accepted as core term.

May 28 2013. Updated definition taken from ReO based on discussions initiated in Philly 2011 workshop.  Former defnition described a narrower view of reagents in chemistry that restricts bearers of the role to be chemical entities (\"a role played by a molecular entity used to produce a chemical reaction to detect, measure, or produce other substances\").  Updated definition allows for broader view of reagents in the domain of biomedical research to include larger materials that have parts that participate chemically in a molecular reaction or interaction.
"""^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:comment """(copied from ReO)
Reagents are distinguished from instruments or devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in or have parts that participate in some chemical interaction or reaction during their intended participation in some technique.  By contrast, instruments do not participate in a chemical reaction/interaction during the technique.

Reagents are distinguished from study subjects/evaluants in that study subjects and evaluants are that about which conclusions are drawn and knowledge is sought in an investigation - while reagents, by definition, are not.  It should be noted, however, that reagent and study subject/evaluant roles can be borne by instances of the same type of material entity - but a given instance will realize only one of these roles in the execution of a given assay or technique. For example, taq polymerase can bear a reagent role or an evaluant role.  In a DNA sequencing assay aimed at generating sequence data about some plasmid, the reagent role of the taq polymerase is realized. In an assay to evaluate the quality of the taq polymerase itself, the evaluant/study subject role of the taq is realized, but not the reagent role since the taq is the subject about which data is generated.

In regard to the statement that reagents are 'distinct' from the specified outputs of a technique, note that a reagent may be incorporated into a material output of a technique, as long as the IDENTITY of this output is distinct from that of the bearer of the reagent role.  For example, dNTPs input into a PCR are reagents that become part of the material output of this technique, but this output has a new identity (ie that of a 'nucleic acid molecule') that is distinct from the identity of the dNTPs that comprise it.  Similarly, a biotin molecule input into a cell labeling technique are reagents that become part of the specified output, but the identity of the output is that of some modified cell specimen which shares identity with the input unmodified cell specimen, and not with the biotin label. Thus, we see that an important criteria of 'reagent-ness' is that it is a facilitator, and not the primary focus of an investigation or material processing technique (ie not the specified subject/evaluant about which knowledge is sought, or the specified output material of the technique).""" ;
    rdfs:label "reagent role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000094
    obo:IAO_0000111 "material processing"^^xsd:string ;
    obo:IAO_0000112 "A cell lysis, production of a cloning vector, creating a buffer."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A planned process which results in physical changes in a specified input material"@en ;
    obo:IAO_0000117 "PERSON: Bjoern Peters"@en, "PERSON: Frank Gibson"^^xsd:string, "PERSON: Jennifer Fostel"^^xsd:string, "PERSON: Melanie Courtot"^^xsd:string, "PERSON: Philippe Rocca Serra"^^xsd:string ;
    obo:IAO_0000118 "material transformation"@en ;
    obo:IAO_0000119 "OBI branch derived"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "material processing"@en ;
    rdfs:subClassOf obo:OBI_0000011, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:OBI_0000047
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:BFO_0000040 ;
        owl:onProperty obo:OBI_0000293
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000456
    ] .

obo:OBI_0000109
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

obo:OBI_0000181
    obo:IAO_0000111 "population"@en ;
    obo:IAO_0000112 "PMID12564891. Environ Sci Technol. 2003 Jan 15;37(2):223-8. Effects of historic PCB exposures on the reproductive success of the Hudson River striped bass population."@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area"@en ;
    obo:IAO_0000116 """1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: 
http://code.google.com/p/popcomm-ontology/""" ;
    obo:IAO_0000117 "PERSON: Philippe Rocca-Serra"@en ;
    obo:IAO_0000119 "adapted from Oxford English Dictionnary"@en ;
    obo:IAO_0000232 "rem1: collection somehow always involve a selection process"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "population"@en ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000237
    obo:IAO_0000111 "antigen role"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "Antigen is a role played by material which when introduced into an immune-competent organism causes an immune response"@en, "a role that inheres in a vaccine component and plays an antigen role, i.e., it is introducd into an immune-competent organism to cause an immune response" ;
    obo:IAO_0000116 "An antigen is a substance that prompts the generation of antibodies and can cause an immune response.  Wikipedia  http://en.wikipedia.org/wiki/Antigen. In the strict sense, immunogens are those substances that elicit a response from the immune system, whereas antigens are defined as substances that bind to specific antibodies. Not all antigens produce an immunogenic response, but all immunogens are antigens"^^xsd:string ;
    obo:IAO_0000117 "Role Branch"@en ;
    obo:IAO_0000119 "OBI"^^xsd:string ;
    obo:IAO_0000232 "9Mar09 waiting for discussion with immunology terms"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "antigen role"@en ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:allValuesFrom obo:GO_0006955 ;
        owl:onProperty obo:BFO_0000054
    ] .

obo:OBI_0000245
    obo:IAO_0000111 "organization"@en ;
    obo:IAO_0000112 "PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods."@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members."@en ;
    obo:IAO_0000116 """BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that.  The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based:

1) there are organization_member_roles (president, treasurer, branch
editor), with individual persons as bearers

2) there are organization_roles (employer, owner, vendor, patent holder)

3) an organization has a charter / rules / bylaws, which specify what roles
there are, how they should be realized, and how to modify the
charter/rules/bylaws themselves.

It is debatable what the organization itself is (some kind of dependent
continuant or an aggregate of people). This also determines who/what the
bearer of organization_roles' are. My personal favorite is still to define
organization as a kind of 'legal entity', but thinking it through leads to
all kinds of questions that are clearly outside the scope of OBI.

Interestingly enough, it does not seem to matter much where we place
organization itself, as long as we can subclass it (University, Corporation,
Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO,
W3C, University of Oklahoma), and have it play roles.

This leads to my proposal: We define organization through the statements 1 -
3 above, but without an 'is a' statement for now. We can leave it in its
current place in the is_a hierarchy (material entity) or move it up to
'continuant'. We leave further clarifications to BFO, and close this issue
for now."""@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"^^xsd:string, "PERSON: Bjoern Peters"^^xsd:string, "PERSON: Philippe Rocca-Serra"^^xsd:string, "PERSON: Susanna Sansone"^^xsd:string ;
    obo:IAO_0000119 "GROUP: OBI"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "organization"@en ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:OBI_0000272
    obo:IAO_0000111 "protocol"@en ;
    obo:IAO_0000112 "PCR protocol, has objective specification, amplify DNA fragment of interest, and has action specification describes the amounts of experimental reagents used (e..g. buffers, dNTPS, enzyme), and the temperature and cycle time settings for running the PCR."@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process."@en ;
    obo:IAO_0000117 "PlanAndPlannedProcess Branch"@en ;
    obo:IAO_0000119 "OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29)"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    obo:OBI_0001847 "study protocol"^^xsd:string ;
    a owl:Class ;
    rdfs:label "protocol"@en ;
    rdfs:subClassOf obo:IAO_0000104 .

obo:OBI_0000274
    obo:IAO_0000111 "adding a material entity into a target"^^xsd:string ;
    obo:IAO_0000112 "Injecting a drug into a mouse. Adding IL-2 to a cell culture. Adding NaCl into water."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "is a process with the objective to place a material entity bearing the 'material to be added role' into a material bearing the 'target of material addition role'."@en ;
    obo:IAO_0000116 "Class was renamed from 'administering substance', as this is commonly used only for additions into organisms."^^xsd:string ;
    obo:IAO_0000117 "BP"^^xsd:string ;
    obo:IAO_0000119 "branch derived"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "adding a material entity into a target"@en ;
    rdfs:subClassOf obo:OBI_0000652, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom obo:OBI_0000319
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom obo:OBI_0000444
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:BFO_0000040
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:OBI_0000319
                ]
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0001025 ;
                    owl:someValuesFrom [
                        a owl:Class ;
                        owl:intersectionOf (obo:BFO_0000040
                            [
                                a owl:Restriction ;
                                owl:onProperty obo:RO_0000087 ;
                                owl:someValuesFrom obo:OBI_0000444
                            ]
                        )
                    ]
                ]
            )
        ]
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000434
    ] .

obo:OBI_0000281
    obo:IAO_0000111 "intraperitoneal injection"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "is the injection of a material entity (bearing the administered substance role) into the peritoneum (bearing the target role) of an organism using a syringe"^^xsd:string ;
    obo:IAO_0000117 "BP"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "intraperitoneal injection"@en ;
    rdfs:subClassOf obo:OBI_0000426, obo:OBI_0000429, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000434
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom obo:OBI_0000319
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:BFO_0000034
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000052 ;
                            owl:someValuesFrom obo:OBI_0000422
                        ]
                    )
                ]
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:OBI_0000444
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000081 ;
                            owl:someValuesFrom obo:UBERON_0002358
                        ]
                    )
                ]
            ]
        )
    ] .

obo:OBI_0000293
    obo:IAO_0000111 "has_specified_input"^^xsd:string, "has_specified_input"@en ;
    obo:IAO_0000112 "see is_input_of example_of_usage"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
    obo:IAO_0000116 "8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works."^^xsd:string ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bjoern Peters"^^xsd:string, "PERSON: Larry Hunter"^^xsd:string, "PERSON: Melanie Coutot"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:OBI_0000011 ;
    rdfs:label "has_specified_input"@en ;
    rdfs:subPropertyOf obo:RO_0000057 ;
    owl:equivalentProperty [
        owl:inverseOf obo:OBI_0000295
    ] ;
    owl:inverseOf obo:OBI_0000295 .

obo:OBI_0000295
    obo:IAO_0000111 "is_specified_input_of"^^xsd:string ;
    obo:IAO_0000112 "some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of."@en ;
    obo:IAO_0000117 "Alan Ruttenberg"@en, "PERSON:Bjoern Peters"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "is_specified_input_of"@en ;
    rdfs:range obo:OBI_0000011 ;
    rdfs:subPropertyOf obo:RO_0000056 .

obo:OBI_0000298
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000231 obo:IAO_0000228 ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

obo:OBI_0000299
    obo:IAO_0000111 "has_specified_output"^^xsd:string, "has_specified_output"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en, "PERSON: Bjoern Peters"^^xsd:string, "PERSON: Larry Hunter"^^xsd:string, "PERSON: Melanie Courtot"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:OBI_0000011 ;
    rdfs:label "has_specified_output"@en ;
    rdfs:subPropertyOf obo:RO_0000057 ;
    owl:equivalentProperty [
        owl:inverseOf obo:OBI_0000312
    ] ;
    owl:inverseOf obo:OBI_0000312 .

obo:OBI_0000300
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000231 obo:IAO_0000228 ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

obo:OBI_0000304
    obo:IAO_0000111 "is_manufactured_by"@en ;
    obo:IAO_0000112 "http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities)"@en ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the \"Manufacturer Role\", and those people/and or machines were members or of directed by the organization to do this."@en ;
    obo:IAO_0000117 "Alan Ruttenberg"@en, "Liju Fan"@en ;
    obo:IAO_0000118 "has_make"@en, "has_manufacturer"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:BFO_0000040 ;
    rdfs:label "is_manufactured_by"@en ;
    rdfs:range [
        a owl:Class ;
        owl:unionOf (obo:NCBITaxon_9606
            obo:OBI_0000245
        )
    ] .

obo:OBI_0000306
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000231 obo:IAO_0000228 ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

obo:OBI_0000308
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000231 obo:IAO_0000228 ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

obo:OBI_0000312
    obo:IAO_0000111 "is_specified_output_of"^^xsd:string, "is_specified_output_of"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of."@en ;
    obo:IAO_0000117 "Alan Ruttenberg"@en, "PERSON:Bjoern Peters"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "is_specified_output_of"@en ;
    rdfs:range obo:OBI_0000011 ;
    rdfs:subPropertyOf obo:RO_0000056 ;
    owl:equivalentProperty [
        owl:inverseOf obo:OBI_0000299
    ] .

obo:OBI_0000316
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000231 obo:IAO_0000228 ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

obo:OBI_0000319
    obo:IAO_0000111 "material to be added role"^^xsd:string ;
    obo:IAO_0000112 "drug added to a buffer contained in a tube; substance injected into an animal;"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "material to be added role is a protocol participant role realized by a material which is added into a material bearing the target of material addition role in a material addition process"@en ;
    obo:IAO_0000117 "Role Branch"^^xsd:string ;
    obo:IAO_0000119 "OBI"^^xsd:string ;
    obo:IAO_0000232 "9 March 09 from discussion with PA branch"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "material to be added role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0000383
    obo:IAO_0000111 "transfer function"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A transfer function is a function to displace a material from one location to another."@en ;
    obo:IAO_0000117 "Bill Bug"^^xsd:string, "Daniel Schober"^^xsd:string, "Frank Gibson"^^xsd:string, "Melanie Courtot"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "transfer function"@en ;
    rdfs:subClassOf obo:BFO_0000034 .

obo:OBI_0000417
    obo:IAO_0000111 "achieves_planned_objective"^^xsd:string ;
    obo:IAO_0000112 "A cell sorting process achieves the objective specification 'material separation objective'"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process."^^xsd:string ;
    obo:IAO_0000117 "BP, AR, PPPB branch"^^xsd:string ;
    obo:IAO_0000119 "PPPB branch derived"^^xsd:string ;
    obo:IAO_0000232 "modified according to email thread from 1/23/09 in accordince with DT and PPPB branch"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:OBI_0000011 ;
    rdfs:label "achieves_planned_objective"^^xsd:string ;
    rdfs:range obo:IAO_0000005 ;
    owl:inverseOf obo:OBI_0000833 .

obo:OBI_0000422
    obo:IAO_0000111 "syringe"^^xsd:string ;
    obo:IAO_0000112 "Accuracy of oral liquid measuring devices: comparison of dosing cup and oral dosing syringe.Ann Pharmacother. 2008 Jan;42(1):46-52. Epub 2007 Dec 4. PMID: 18056832"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A processed material which is used to introduce or draw fluids from a material entity. A syringe is made of a piston and body. the movement of the piston in the body determines the amount/volume of fluid to inject or draw"^^xsd:string ;
    obo:IAO_0000117 "Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000119 "OBI Instrument adapted from Wikipedia"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "syringe"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0000968, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000085 ;
        owl:someValuesFrom obo:OBI_0000383
    ] .

obo:OBI_0000426
    obo:IAO_0000111 "injection"^^xsd:string ;
    obo:IAO_0000112 "Multiple Small-Dose Injections Can Reduce the Passage of Sclerosant Foam into Deep Veins During Foam Sclerotherapy for Varicose Veins. Eur J Vasc Endovasc Surg. 2008 Oct 13. PMID: 18922712"@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "injection is process which aims at introducing a compound or a mixture into a material entity (either biological entity or instrument) by relying on devices such as syringe or injector connection, attached or forced into a vascular system (veins of an organism or tubes of a machine) or in a tissue."@en ;
    obo:IAO_0000117 "Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000119 "OBI Biomaterial"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "injection"@en ;
    rdfs:subClassOf obo:OBI_0000274, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000434
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom obo:OBI_0000319
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:BFO_0000034
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000052 ;
                            owl:someValuesFrom obo:OBI_0000422
                        ]
                    )
                ]
            ]
        )
    ] .

obo:OBI_0000429
    obo:IAO_0000111 "intraperitoneal administration"^^xsd:string ;
    obo:IAO_0000112 "Rats were injected intraperitoneally with either rrIL-6 (250 ng/0.5 ml) or equal-volume sterile saline twice within an interval of 24 h"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "The administration of a substance into the peritoneum of an organism"^^xsd:string ;
    obo:IAO_0000117 "Person:Bjoern Peters"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "intraperitoneal administration"@en ;
    rdfs:subClassOf obo:OBI_0600007, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000434
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom obo:OBI_0000319
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:OBI_0000444
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000081 ;
                            owl:someValuesFrom obo:UBERON_0002358
                        ]
                    )
                ]
            ]
        )
    ] .

obo:OBI_0000434
    obo:IAO_0000111 "adding material objective"^^xsd:string ;
    obo:IAO_0000112 "creating a mouse infected with LCM virus"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "is the specification of an objective to add a material into a target material. The adding is asymmetric in the sense that the target material largely retains its identity"@en ;
    obo:IAO_0000117 "BP"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "adding material objective"@en ;
    rdfs:subClassOf obo:OBI_0000686 .

obo:OBI_0000441
    obo:IAO_0000111 "assay objective"^^xsd:string ;
    obo:IAO_0000112 "the objective to determine the weight of a mouse."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role)"@en ;
    obo:IAO_0000117 "PPPB branch"^^xsd:string ;
    obo:IAO_0000119 "PPPB branch"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "assay objective"@en ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0000444
    obo:IAO_0000111 "target of material addition role"^^xsd:string ;
    obo:IAO_0000112 "peritoneum of an animal receiving an interperitoneal injection; solution in a tube receiving additional material; location of absorbed material following a dermal application."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "target of material addition role is a role realized by an entity into which a material is added in a material addition process"^^xsd:string ;
    obo:IAO_0000116 "From Branch discussion with BP, AR, MC -- there is a need for the recipient to interact with the administered material.  for example, a tooth receiving a filling was not considered to be a target role."^^xsd:string ;
    obo:IAO_0000117 "GROUP:  Role Branch"^^xsd:string ;
    obo:IAO_0000119 "OBI"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "target of material addition role"@en ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom obo:BFO_0000040
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:OBI_0000274 ;
        owl:onProperty obo:BFO_0000054
    ] .

obo:OBI_0000450
    obo:IAO_0000111 "regulatory agency"@en ;
    obo:IAO_0000112 "The US Environmental Protection Agency"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A regulatory agency is a organization that has responsibility over or for  the legislation (acts and regulations) for a given sector of the government."@en ;
    obo:IAO_0000117 "GROUP: OBI Biomaterial Branch"^^xsd:string ;
    obo:IAO_0000119 "WEB: en.wikipedia.org/wiki/Regulator"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "regulatory agency"@en ;
    rdfs:subClassOf obo:OBI_0000245 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:OBI_0000245
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:OBI_0000014
            ]
        )
    ] .

obo:OBI_0000456
    obo:IAO_0000111 "material transformation objective"^^xsd:string ;
    obo:IAO_0000112 "The objective to create a mouse infected with LCM virus. The objective to create a defined solution of PBS."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "an objective specifiction that creates an specific output object from input materials."@en ;
    obo:IAO_0000117 "PERSON: Bjoern Peters"^^xsd:string, "PERSON: Frank Gibson"^^xsd:string, "PERSON: Jennifer Fostel"^^xsd:string, "PERSON: Melanie Courtot"^^xsd:string, "PERSON: Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000118 "artifact  creation objective"@en ;
    obo:IAO_0000119 "GROUP: OBI PlanAndPlannedProcess Branch"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "material transformation objective"@en ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0000576
    obo:IAO_0000111 "scattered molecular aggregate"^^xsd:string ;
    obo:IAO_0000112 "the sodium and chloride ions in a glass of salt water"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates"@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ;
    obo:IAO_0000118 "Collective"@en ;
    obo:IAO_0000119 "Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. With inspiration from the paper Granularity, scale and collectivity: When size does and does not matter, Alan Recto, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "scattered molecular aggregate"@en ;
    rdfs:subClassOf obo:BFO_0000040, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000643 ;
        owl:someValuesFrom obo:CHEBI_23367
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:CHEBI_23367 ;
        owl:onProperty obo:OBI_0000643
    ] .

obo:OBI_0000643
    obo:IAO_0000111 "has grain"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car."^^xsd:string ;
    obo:IAO_0000116 "Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form"@en ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"@en ;
    obo:IAO_0000119 "PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has grain"^^xsd:string ;
    rdfs:subPropertyOf obo:BFO_0000051 .

obo:OBI_0000652
    obo:IAO_0000111 "material combination"^^xsd:string ;
    obo:IAO_0000112 "Mixing two fluids. Adding salt into water. Injecting a mouse with PBS."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "is a material processing with the objective to combine two or more material entities as input into a single material entity as output."^^xsd:string ;
    obo:IAO_0000116 "created at workshop as parent class for 'adding material into target', which is asymmetric, while combination encompasses all addition processes."^^xsd:string ;
    obo:IAO_0000117 "bp"^^xsd:string ;
    obo:IAO_0000119 "bp"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "material combination"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0000094, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:BFO_0000040
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:BFO_0000040
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000686
    ] .

obo:OBI_0000685
    obo:IAO_0000111 "creating a mixture of molecules in solution"^^xsd:string ;
    obo:IAO_0000112 "The production of PBS"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "is a process with the objective to prepare a liquid solution of one or more chemicals at desired concentrations."^^xsd:string ;
    obo:IAO_0000117 "Bjoern Peters"^^xsd:string ;
    obo:IAO_0000119 "PERSON: Helen Parkinson"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "creating a mixture of molecules in solution"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0000652, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:BFO_0000040
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:OBI_0302729
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000456
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000686
    ] .

obo:OBI_0000686
    obo:IAO_0000111 "material combination objective"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "is an objective to obtain an output material that contains several input materials."^^xsd:string ;
    obo:IAO_0000117 "PPPB branch"^^xsd:string ;
    obo:IAO_0000119 "bp"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "material combination objective"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0000456 .

obo:OBI_0000712
    obo:IAO_0000111 "pathogen challenge"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "A pathogen challenge is the administration of a live pathogenic organism to a host"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "pathogen challenge"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0600007, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom obo:OBI_0000725
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:OBI_0000319
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000081 ;
                    owl:someValuesFrom [
                        a owl:Class ;
                        owl:intersectionOf (obo:OBI_0100026
                            [
                                a owl:Restriction ;
                                owl:onProperty obo:RO_0000087 ;
                                owl:someValuesFrom obo:OBI_0000718
                            ]
                        )
                    ]
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:OBI_0000444
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000081 ;
                    owl:someValuesFrom [
                        a owl:Class ;
                        owl:intersectionOf (obo:OBI_0100026
                            [
                                a owl:Restriction ;
                                owl:onProperty obo:RO_0000087 ;
                                owl:someValuesFrom obo:OBI_0000725
                            ]
                        )
                    ]
                ]
            )
        ]
    ] .

obo:OBI_0000718
    obo:IAO_0000111 "pathogen role"^^xsd:string ;
    obo:IAO_0000112 "Pathogen: An agent of disease. A disease producer. The term pathogen most commonly is used to refer to infectious organisms. These include bacteria (such as staph), viruses (such as HIV), and fungi (such as yeast). Less commonly, pathogen refers to a noninfectious agent of disease such as a chemical.   http://www.medterms.com/script/main/art.asp?articlekey=6383"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "pathogen role is a role which inheres in an organism and realized in the process of disease course in the organism bearing host role caused by the organism bearing pathogen role"^^xsd:string ;
    obo:IAO_0000117 "GROUP: Role Branch"^^xsd:string ;
    obo:IAO_0000119 "OBI"^^xsd:string ;
    obo:IAO_0000232 "6 April 2009:  from the Vaccine Community"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "pathogen role"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom obo:OBI_0100026
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:OGMS_0000063 ;
        owl:onProperty obo:BFO_0000054
    ] .

obo:OBI_0000725
    obo:IAO_0000111 "host role"^^xsd:string ;
    obo:IAO_0000112 "In biology, a host is an organism that harbors a virus or parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter.  http://en.wikipedia.org/wiki/Host_(biology)  30 March 09"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role"^^xsd:string ;
    obo:IAO_0000116 "30Mar09 virus reproducing inside a cell; bacteria causing a disease, host can be harmed or not.  we want to avoid a cat sitting on my lap and an animal care technician; these are not examples or hosts; dental cares = on tooth, but part of outer layer of tooth, so covered by \"within\" in the definition"^^xsd:string ;
    obo:IAO_0000117 "GROUP: Role Branch"^^xsd:string ;
    obo:IAO_0000119 "30 Mar09 submitted by vaccine community"^^xsd:string, "OBI"^^xsd:string, "http://en.wikipedia.org/wiki/Host_(biology)"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "host role"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom obo:OBI_0100026
    ] .

obo:OBI_0000750
    obo:IAO_0000111 "independent variable specification"^^xsd:string ;
    obo:IAO_0000112 "In a study in which gene expression is measured in patients between 8 month to 4 years old that have mild or severe malaria and in which the hypothesis is that gene expression in that age group is a function of disease status, disease status is the independent variable." ;
    obo:IAO_0000114 obo:IAO_0000122, obo:IAO_0000125 ;
    obo:IAO_0000115 "a directive information entity that is part of a study design. Independent variables are entities whose values are selected to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled"@en ;
    obo:IAO_0000116 "2/2/2009 Original definition - In the design of experiments, independent variables are those whose values are controlled or selected by the person experimenting (experimenter) to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled."@en, "In the Philly 2013 workshop the label was chosen to distinguish it from \"dependent variable\" as used in statistical modelling. See: http://en.wikipedia.org/wiki/Statistical_modeling" ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"^^xsd:string, "PERSON: Bjoern Peters"^^xsd:string, "PERSON: Chris Stoeckert"^^xsd:string ;
    obo:IAO_0000118 "experimental factor", "independent variable" ;
    obo:IAO_0000119 "Web: http://en.wikipedia.org/wiki/Dependent_and_independent_variables"^^xsd:string ;
    obo:IAO_0000232 "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify thisdefinition please notify OBI."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    obo:OBI_0001847 "study factor"^^xsd:string ;
    a owl:Class ;
    rdfs:label "independent variable specification"^^xsd:string, "study design independent variable"@en ;
    rdfs:subClassOf obo:IAO_0000033, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:OBI_0500000
    ] .

obo:OBI_0000751
    obo:IAO_0000111 "dependent variable specification"^^xsd:string ;
    obo:IAO_0000112 "In a study in which gene expression is measured in patients between 8 month to 4 years old that have mild or severe malaria and in which the hypothesis is that gene expression in that age group is a function of disease status, the gene expression is the dependent variable. " ;
    obo:IAO_0000114 obo:IAO_0000122, obo:IAO_0000125 ;
    obo:IAO_0000115 "dependent variable specification is part of a study design. The dependent variable is the event studied and expected to change when the independent variable varies."@en ;
    obo:IAO_0000116 "2/2/2009 In the design of experiments, independent variables are those whose values are controlled or selected by the person experimenting (experimenter) to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled."@en, "In the Philly 2013 workshop the label was chosen to distinguish it from \"dependent variable\" as used in statistical modelling. See: http://en.wikipedia.org/wiki/Statistical_modeling" ;
    obo:IAO_0000117 "PERSON: Alan Ruttenberg"^^xsd:string, "PERSON: Bjoern Peters"^^xsd:string, "PERSON: Chris Stoeckert"^^xsd:string ;
    obo:IAO_0000118 "dependent variable" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Dependent_and_independent_variables"^^xsd:string ;
    obo:IAO_0000232 "2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify thisdefinition please notify OBI."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "dependent variable specification"^^xsd:string, "study design dependent variable"@en ;
    rdfs:subClassOf obo:IAO_0000033, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:OBI_0500000
    ] .

obo:OBI_0000806
    obo:IAO_0000111 "material maintenance objective"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An objective specification maintains some or all of the qualities of a material over time."^^xsd:string ;
    obo:IAO_0000117 "PERSON: Bjoern Peters"^^xsd:string ;
    obo:IAO_0000119 "PERSON: Bjoern Peters"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "material maintenance objective"^^xsd:string ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0000833
    obo:IAO_0000111 "objective_achieved_by"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process."^^xsd:string ;
    obo:IAO_0000117 "OBI" ;
    obo:IAO_0000119 "OBI" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:IAO_0000005 ;
    rdfs:label "objective_achieved_by"^^xsd:string ;
    rdfs:range obo:OBI_0000011 .

obo:OBI_0000838
    obo:IAO_0000111 "material maintenance"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "a process with that achieves the objective to maintain some or all of the characteristics of an input material over time"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "material maintenance"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0000011 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000806
    ] .

obo:OBI_0000938
    obo:IAO_0000111 "categorical measurement datum"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "A measurement datum that is reported on a categorical scale"^^xsd:string ;
    obo:IAO_0000117 "Bjoern Peters"^^xsd:string ;
    obo:IAO_0000118 "nominal mesurement datum"^^xsd:string ;
    obo:IAO_0000119 """Bjoern Peters
"""^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "categorical measurement datum"^^xsd:string ;
    rdfs:subClassOf obo:IAO_0000109, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0001938 ;
        owl:someValuesFrom obo:OBI_0001930
    ] .

obo:OBI_0000968
    obo:IAO_0000111 "device"^^xsd:string ;
    obo:IAO_0000112 "A voltmeter is a measurement device which is intended to perform some measure function."^^xsd:string, "An autoclave is a device that sterlizes instruments or contaminated waste by applying high temperature and pressure."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A material entity that is designed to perform a function in a scientific investigation, but is not a reagent."^^xsd:string ;
    obo:IAO_0000116 """2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of \"device\", and are enumerating the types of roles that a reagent can perform.

2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions.  Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear.  For example:

(1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component.  This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part.

(2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay.

(3) A gel running  box  is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it.  This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel.

In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation).  In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay.  """^^xsd:string ;
    obo:IAO_0000117 "PERSON: Helen Parkinson"^^xsd:string ;
    obo:IAO_0000118 "instrument"^^xsd:string ;
    obo:IAO_0000119 "OBI development call 2012-12-17."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "device"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0000047, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000312 ;
        owl:someValuesFrom obo:OBI_0000094
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000085 ;
        owl:someValuesFrom obo:BFO_0000034
    ] .

obo:OBI_0000969
    obo:IAO_0000111 "dose specification"^^xsd:string ;
    obo:IAO_0000112 "a protocol specifying to administer 1 ml of vaccine to a mouse"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "a directive information entity that describes the dose that will be administered to a target"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "dose specification"^^xsd:string ;
    rdfs:subClassOf obo:IAO_0000033 .

obo:OBI_0000984
    obo:IAO_0000111 "dose"^^xsd:string ;
    obo:IAO_0000112 "An organism has been injected 1ml of vaccine"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "dose"^^xsd:string ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:OBI_0001847
    obo:IAO_0000111 "ISA alternative term"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An alternative term used by the ISA tools project (http://isa-tools.org)." ;
    obo:IAO_0000116 """Requested by Alejandra Gonzalez-Beltran
https://sourceforge.net/tracker/?func=detail&aid=3603413&group_id=177891&atid=886178""" ;
    obo:IAO_0000117 "Person: Alejandra Gonzalez-Beltran", "Person: Philippe Rocca-Serra" ;
    obo:IAO_0000119 "ISA tools project (http://isa-tools.org)" ;
    a owl:AnnotationProperty ;
    rdfs:label "ISA alternative term", "ISA alternative term"@en ;
    rdfs:subPropertyOf obo:IAO_0000118 .

obo:OBI_0001930
    obo:IAO_0000111 "categorical value specification" ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "A value specification that is specifies one category out of a fixed number of nominal categories" ;
    obo:IAO_0000117 "PERSON:Bjoern Peters" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "categorical value specification" ;
    rdfs:subClassOf obo:OBI_0001933 .

obo:OBI_0001933
    obo:IAO_0000111 "value specification" ;
    obo:IAO_0000112 "The value of 'positive' in a classification scheme of \"positive or negative\"; the value of '20g' on the quantitative scale of mass." ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An information content entity that specifies a value within a classification scheme or on a quantitative scale." ;
    obo:IAO_0000116 "This term is currently a descendant of 'information content entity', which requires that it 'is about' something. A value specification of '20g' for a measurement data item of the mass of a particular mouse 'is about' the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change 'value specification' to remove the 'is about' requirement." ;
    obo:IAO_0000117 "PERSON:Bjoern Peters" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "value specification" ;
    rdfs:subClassOf obo:IAO_0000030 .

obo:OBI_0001938
    obo:IAO_0000111 "has value specification" ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "A relation between an information content entity and a value specification that specifies its value." ;
    obo:IAO_0000117 "PERSON: James A. Overton" ;
    obo:IAO_0000119 "OBI" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:IAO_0000030 ;
    rdfs:label "has value specification" ;
    rdfs:range obo:OBI_0001933 ;
    rdfs:subPropertyOf obo:BFO_0000051 .

obo:OBI_0100015
    obo:IAO_0000114 obo:IAO_0000121 ;
    obo:IAO_0000231 obo:IAO_0000228 ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

obo:OBI_0100026
    obo:IAO_0000111 "organism"@en ;
    obo:IAO_0000112 "animal"@en, "fungus"@en, "plant"@en, "virus"@en ;
    obo:IAO_0000114 obo:IAO_0000121, obo:IAO_0000122 ;
    obo:IAO_0000115 "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs."@en ;
    obo:IAO_0000116 "10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms')"^^xsd:string, """13-02-2009:
OBI doesn't take position as to  when an organism starts or ends being an organism - e.g. sperm, foetus.
This issue is outside the scope of OBI."""^^xsd:string ;
    obo:IAO_0000117 "GROUP: OBI Biomaterial Branch"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Organism"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogg.owl> ;
    a owl:Class ;
    rdfs:label "organism"@en ;
    rdfs:subClassOf obo:BFO_0000040 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:unionOf (obo:NCBITaxon_10239
            obo:NCBITaxon_2
            obo:NCBITaxon_2157
            obo:NCBITaxon_2759
        )
    ] .

obo:OBI_0100046
    obo:IAO_0000111 "phosphate buffered saline solution"@en ;
    obo:IAO_0000112 "PMID: 16279733.Dent Mater J. 2005 Sep;24(3):414-21.PBS buffer solutions with different pH values can change porosity of DNA-chitosan complexes."@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "Phosphate buffered saline (abbreviated PBS) is a buffer solution commonly used in biochemistry. It is a salty solution containing sodium chloride, sodium phosphate and in some preparations potassium chloride and potassium phosphate. The buffer helps to maintain a constant pH. The concentration usually matches the human body (isotonic)."@en ;
    obo:IAO_0000117 "PERSON: Melanie Courtot"@en, "PERSON: Philippe Rocca-Serra"^^xsd:string, "PERSON: Tina Boussard"@en ;
    obo:IAO_0000118 "PBS buffer"@en ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Phosphate_buffered_saline"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "phosphate buffered saline solution"@en ;
    rdfs:subClassOf obo:OBI_0302729, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:OBI_0000576
                [
                    a owl:Restriction ;
                    owl:allValuesFrom obo:CHEBI_26710 ;
                    owl:onProperty obo:OBI_0000643
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:OBI_0000576
                [
                    a owl:Restriction ;
                    owl:allValuesFrom obo:CHEBI_37586 ;
                    owl:onProperty obo:OBI_0000643
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:OBI_0302731
    ] .

obo:OBI_0200000
    obo:IAO_0000111 "data transformation"@en ;
    obo:IAO_0000112 "The application of a clustering protocol to microarray data or the application of a statistical testing method on a primary data set to determine a p-value."^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000122, obo:IAO_0000125 ;
    obo:IAO_0000115 "A planned process that produces output data from input data."@en ;
    obo:IAO_0000117 "Elisabetta Manduchi"@en, "Helen Parkinson"@en, "James Malone"@en, "Melanie Courtot"@en, "Philippe Rocca-Serra"^^xsd:string, "Richard Scheuermann"@en, "Ryan Brinkman"@en, "Tina Hernandez-Boussard"@en ;
    obo:IAO_0000118 "data analysis"@en, "data processing"@en ;
    obo:IAO_0000119 "Branch editors"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "data transformation"@en ;
    rdfs:subClassOf obo:OBI_0000011, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom [
            a owl:Restriction ;
            owl:onProperty obo:RO_0000059 ;
            owl:someValuesFrom [
                a owl:Class ;
                owl:intersectionOf (obo:IAO_0000064
                    [
                        a owl:Restriction ;
                        owl:onProperty obo:BFO_0000051 ;
                        owl:someValuesFrom obo:IAO_0000005
                    ]
                )
            ]
        ]
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:IAO_0000027 ;
        owl:onProperty obo:OBI_0000293
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0200166
    ] .

obo:OBI_0200166
    obo:IAO_0000111 "data transformation objective"@en ;
    obo:IAO_0000112 "normalize objective"@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An objective specification to transformation input data into output data"@en ;
    obo:IAO_0000116 "Modified definition in 2013 Philly OBI workshop" ;
    obo:IAO_0000117 "James Malone"@en ;
    obo:IAO_0000119 "PERSON: James Malone"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "data transformation objective"@en ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:OBI_0200201
    obo:IAO_0000111 "ANOVA"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "ANOVA or analysis of variance is a data transformation in which a statistical test of whether the means of several groups are all equal."^^xsd:string ;
    obo:IAO_0000117 "James Malone"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "ANOVA"^^xsd:string ;
    rdfs:subClassOf obo:OBI_0200000 .

obo:OBI_0302729
    obo:IAO_0000111 "chemical solution"@en ;
    obo:IAO_0000112 "PMID: 18289311.Anesth Analg. 2008 Apr;106(4):1078-86.Less impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatin or 6% hydroxyethyl starch solution."@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A material entity  that is made up of at least 2 scattered molecular aggregates, one playing the role of solvent and the other one playing the role of solute."@en ;
    obo:IAO_0000117 "PERSON: Bjoern Peters"^^xsd:string, "PERSON: Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000118 "liquid chemical solution"@en ;
    obo:IAO_0000119 "GROUP: OBI Biomaterial Branch"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "chemical solution"@en ;
    rdfs:subClassOf obo:BFO_0000040 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000051 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:OBI_0000576
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000087 ;
                            owl:someValuesFrom obo:OBI_0302732
                        ]
                    )
                ]
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000051 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:OBI_0000576
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000087 ;
                            owl:someValuesFrom obo:OBI_0302733
                        ]
                    )
                ]
            ]
        )
    ] .

obo:OBI_0302731
    obo:IAO_0000111 "buffer role"^^xsd:string ;
    obo:IAO_0000112 "A buffer of carbonic acid (H2CO3) and bicarbonate (HCO3-) is present in blood plasma, to maintain a pH between 7.35 and 7.45. http://en.wikipedia.org/wiki/Buffer_solution"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "a role which inheres in some molecular entity realized during the process of buffering"^^xsd:string ;
    obo:IAO_0000117 "Person:Helen Parkinson"^^xsd:string, "Person:Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000118 "buffer"^^xsd:string ;
    obo:IAO_0000119 "OBI"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "buffer role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:OBI_0302732
    obo:IAO_0000111 "solvent role"^^xsd:string ;
    obo:IAO_0000112 "PMID: 18373502.Transfusion. 2008 Mar 25. Solvent/detergent treatment of platelet concentrates enhances the release of growth factors."@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "solvent role is a role which inheres in a molecular entity capable of ensuring the dissolution of another chemical entity and realized by the process of solvation"@en ;
    obo:IAO_0000117 "Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000119 "adpated from wikipedia (http://en.wikipedia.org/wiki/Solvatation)"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "solvent role"@en ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom obo:CHEBI_23367
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:OBI_0000685 ;
        owl:onProperty obo:BFO_0000054
    ] .

obo:OBI_0302733
    obo:IAO_0000111 "solute role"^^xsd:string ;
    obo:IAO_0000112 "PMID: 18380397.Pharmazie. 2008 Feb;63(2):113-21.Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model--effect of solute structure."@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "solute role is a role played by a chemical entity which is dissolved by another chemical entity (the solvent) when creating a solution"@en ;
    obo:IAO_0000117 "Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000119 "adapted from wikipedia (http://en.wikipedia.org/wiki/Solute)"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "solute role"@en ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom obo:CHEBI_23367
    ], [
        a owl:Restriction ;
        owl:allValuesFrom obo:OBI_0000685 ;
        owl:onProperty obo:BFO_0000054
    ] .

obo:OBI_0302893
    obo:IAO_0000111 "storage"^^xsd:string ;
    obo:IAO_0000112 "PMID: 18550121.Total Prostate Specific Antigen Stability Confirmed After Long-Term Storage of Serum at -80C. J Urol. 2008 Jun 10."@en ;
    obo:IAO_0000114 obo:IAO_0000120 ;
    obo:IAO_0000115 "A maintenance process by which material entities that are not actively metabolizing are placed in well identified location and possibly under controlled environment in ad-hoc devices/structures in order to preserve and protect them from decay/alteration and maintain availability"@en ;
    obo:IAO_0000117 "Philippe Rocca-Serra"^^xsd:string ;
    obo:IAO_0000119 "OBI-Branch"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "storage"@en ;
    rdfs:subClassOf obo:OBI_0000838, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:BFO_0000040
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000806
    ] .

obo:OBI_0500000
    obo:IAO_0000111 "study design"@en ;
    obo:IAO_0000112 "a matched pairs study design describes criteria by which subjects are identified as pairs which then undergo the same protocols, and the data generated is analyzed by comparing the differences between the paired subjects, which constitute the results of the executed study design."@en ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution."^^xsd:string ;
    obo:IAO_0000116 "Editor note: there is at least an implicit restriction on the kind of data transformations that can be done based on the measured data available."^^xsd:string ;
    obo:IAO_0000117 "PERSON: Chris Stoeckert"^^xsd:string ;
    obo:IAO_0000118 "experimental design"@en ;
    obo:IAO_0000232 "rediscussed at length (MC/JF/BP). 12/9/08). The definition was clarified to differentiate it from protocol."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "study design"@en ;
    rdfs:subClassOf obo:IAO_0000104, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:OBI_0000272
    ] .

obo:OBI_0600007
    obo:IAO_0000111 "administering substance in vivo"@en ;
    obo:IAO_0000112 "Balb/c mice received an intracameral or subconjunctival injection of trinitrophenylated spleen cells"^^xsd:string, "injecting mice with 10 ug morphine intranasally, a patient taking two pills of 1 mg aspirin orally"@en ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "A process by which a substance is intentionally given to an organism resulting in exposure of the organism to that substance."^^xsd:string ;
    obo:IAO_0000116 "2009-11-10. Tracker: https://sourceforge.net/tracker/?func=detail&aid=2893050&group_id=177891&atid=886178"^^xsd:string, "Different routes and means of administration should go as children underneath this"@en, """Update the definition based on the discussion. Details see the tracker:
https://sourceforge.net/p/obi/obi-terms/738/""", "needs roles such as perturber and perturbee (children of input role). Perturb is too strong. Host might be the name for one role. Others considered: Doner, Donated, Acceptor."@en ;
    obo:IAO_0000117 "Bjoern Peters"@en, "Person:Bjoern Peters"^^xsd:string ;
    obo:IAO_0000119 "IEDB"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "administering substance in vivo"@en ;
    rdfs:subClassOf obo:OBI_0000011 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom obo:OBI_0000319
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:OBI_0000444
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000081 ;
                            owl:someValuesFrom [
                                a owl:Class ;
                                owl:unionOf (obo:OBI_0100026
                                    obo:UBERON_0000465
                                )
                            ]
                        ]
                    )
                ]
            ]
        )
    ] .

obo:OBI_1110034
    obo:IAO_0000111 "antigen"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "is a material entity that has the antigen role"@en ;
    obo:IAO_0000117 "IEDB"@en ;
    obo:IAO_0000119 "IEDB"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "antigen"@en ;
    rdfs:subClassOf obo:BFO_0000040 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:BFO_0000040
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:OBI_0000237
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:OBI_1110120
    ] .

obo:OBI_1110120
    obo:IAO_0000111 "assay antigen role"^^xsd:string ;
    obo:IAO_0000114 obo:IAO_0000123 ;
    obo:IAO_0000115 "Any molecule recognized by the adaptive immune receptors? Recognized means bound with a certain affinity? From GO ag binding:Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. see OBI_1110120 below"@en ;
    obo:IAO_0000117 "IEDB"@en ;
    obo:IAO_0000119 "IEDB"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class ;
    rdfs:label "assay antigen role"@en ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:allValuesFrom obo:OBI_0000070 ;
        owl:onProperty obo:BFO_0000054
    ] .

obo:OBI_9991118
    obo:IAO_0000111 "IEDB alternative term" ;
    obo:IAO_0000114 obo:IAO_0000122 ;
    obo:IAO_0000115 "An alternative term used by the IEDB."^^xsd:string ;
    obo:IAO_0000117 "PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters"^^xsd:string ;
    obo:IAO_0000119 "IEDB"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:label "IEDB alternative term" ;
    rdfs:subPropertyOf obo:IAO_0000118 .

obo:OGG_0000000001
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_0000000002
    obo:IAO_0000115 "A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule. " ;
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/books/NBK21640/" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    a owl:Class ;
    rdfs:label "gene"@en ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:OGG_0000000003
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_0000000006
    obo:IAO_0000115 "A GeneID in the NCBI Gene database " ;
    obo:IAO_0000117 "Oliver He, Yue Liu" ;
    a owl:AnnotationProperty ;
    rdfs:label "NCBI GeneID", "NCBI GeneID"@en .

obo:OGG_0000000007
    obo:IAO_0000115 "the NCBI LocusTag name of a gene " ;
    obo:IAO_0000117 "Oliver He, Yue Liu" ;
    a owl:AnnotationProperty ;
    rdfs:label "NCBI LocusTag", "NCBI LocusTag"@en .

obo:OGG_0000000009
    obo:IAO_0000115 "a date of content modification" ;
    obo:IAO_0000117 "Oliver He, Yue Liu" ;
    a owl:AnnotationProperty ;
    rdfs:label "modification date", "modification date"@en .

obo:OGG_0000000010
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_0000000014
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_0000000015
    obo:IAO_0000115 "The NCBITaxon ontology ID of an organism." ;
    obo:IAO_0000117 "Oliver He, Yue Liu" ;
    a owl:AnnotationProperty ;
    rdfs:label "organism NCBITaxon ID", "organism NCBITaxon ID"@en .

obo:OGG_0000000016
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_0000000017
    obo:IAO_0000115 "A chromosome ID where a gene is located." ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:AnnotationProperty ;
    rdfs:label "chromosome ID of gene", "chromosome ID of gene"@en .

obo:OGG_0000000018
    obo:IAO_0000115 "an annotation property that specifies the type of a gene" ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:AnnotationProperty ;
    rdfs:label "type of gene", "type of gene"@en .

obo:OGG_0000000019
    obo:IAO_0000115 "an annotation property that specifies a nomenclature status" ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:AnnotationProperty ;
    rdfs:label "nomenclature status", "nomenclature status"@en .

obo:OGG_0000000030
    obo:IAO_0000115 "An annotation property that represents a gene's association with PubMed publication(s). " ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:AnnotationProperty ;
    rdfs:label "has PubMed association", "has PubMed association"@en .

obo:OGG_1000000002
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_1000001224
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_1000083332
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_1000224914
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> .

obo:OGG_2000000002
    obo:IAO_0000115 "A gene of an organism of Bacteria"^^xsd:string ;
    obo:IAO_0000117 "Yue Liu, Bin Zhao, Oliver He"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000015 "2"^^xsd:string ;
    a owl:Class ;
    rdfs:label "gene of Bacteria"^^xsd:string ;
    rdfs:subClassOf obo:OGG_0000000002 .

obo:OGG_2000001224
    obo:IAO_0000115 "A gene of an organism of Proteobacteria"^^xsd:string ;
    obo:IAO_0000117 "Yue Liu, Bin Zhao, Oliver He"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000015 "1224"^^xsd:string ;
    a owl:Class ;
    rdfs:label "gene of Proteobacteria"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2000000002 .

obo:OGG_2000083332
    obo:IAO_0000115 "A gene of an organism of Mycobacterium tuberculosis H37Rv"^^xsd:string ;
    obo:IAO_0000117 "Yue Liu, Bin Zhao, Oliver He"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    a owl:Class ;
    rdfs:label "gene of Mycobacterium tuberculosis H37Rv"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2000000002 .

obo:OGG_2000224914
    obo:IAO_0000115 "A gene of an organism of Brucella melitensis bv. 1 str. 16M"^^xsd:string ;
    obo:IAO_0000117 "Yue Liu, Bin Zhao, Oliver He"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000015 "224914"^^xsd:string ;
    a owl:Class ;
    rdfs:label "gene of Brucella melitensis bv. 1 str. 16M"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2000001224 .

obo:OGG_2060083332
    obo:IAO_0000115 "A gene of Mycobacterium tuberculosis H37Rv that has a protein-coding gene disposition"^^xsd:string ;
    obo:IAO_0000117 "Bin Zhao, Oliver He"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    a owl:Class ;
    rdfs:label "protein-coding gene of Mycobacterium tuberculosis H37Rv"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2000083332 .

obo:OGG_2060224914
    obo:IAO_0000115 "A gene of Brucella melitensis bv. 1 str. 16M that has a protein-coding gene disposition"^^xsd:string ;
    obo:IAO_0000117 "Bin Zhao, Oliver He"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000015 "224914"^^xsd:string ;
    a owl:Class ;
    rdfs:label "protein-coding gene of Brucella melitensis bv. 1 str. 16M"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2000224914 .

obo:OGG_3000885459
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "885459"^^xsd:string ;
    obo:OGG_0000000007 "Rv3602c"^^xsd:string ;
    obo:OGG_0000000009 "20140405"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 20980199"^^xsd:string ;
    dc:description "Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)"^^xsd:string ;
    a owl:Class ;
    rdfs:label "panC"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000885594
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "885594"^^xsd:string ;
    obo:OGG_0000000007 "Rv1821"^^xsd:string ;
    obo:OGG_0000000009 "20140329"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 17030572; 18487341; 19240020; 20980199; 24297168"^^xsd:string ;
    dc:description "Possible preprotein translocase ATPase SecA2"^^xsd:string ;
    a owl:Class ;
    rdfs:label "secA2"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000885596
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "885596"^^xsd:string ;
    obo:OGG_0000000007 "Rv3601c"^^xsd:string ;
    obo:OGG_0000000009 "20140405"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 20980199"^^xsd:string ;
    dc:description "Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase)"^^xsd:string ;
    a owl:Class ;
    rdfs:label "panD"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000886960
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "886960"^^xsd:string ;
    obo:OGG_0000000007 "Rv1293"^^xsd:string ;
    obo:OGG_0000000009 "20140405"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 16511157; 19543810; 20980199"^^xsd:string ;
    dc:description "Diaminopimelate decarboxylase LysA (DAP decarboxylase)"^^xsd:string ;
    a owl:Class ;
    rdfs:label "lysA"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000887603
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "887603"^^xsd:string ;
    obo:OGG_0000000007 "Rv2930"^^xsd:string ;
    obo:OGG_0000000009 "20140322"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 15749014; 20553505; 20980199"^^xsd:string ;
    dc:description "Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)"^^xsd:string ;
    a owl:Class ;
    rdfs:label "fadD26"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000887681
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "887681"^^xsd:string ;
    obo:OGG_0000000007 "Rv2192c"^^xsd:string ;
    obo:OGG_0000000009 "20140405"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 16337227; 20980199; 23363292"^^xsd:string ;
    dc:description "Probable anthranilate phosphoribosyltransferase TrpD"^^xsd:string ;
    a owl:Class ;
    rdfs:label "trpD"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000888225
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "888225"^^xsd:string ;
    obo:OGG_0000000007 "Rv2987c"^^xsd:string ;
    obo:OGG_0000000009 "20140405"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 19194004; 20980199"^^xsd:string ;
    dc:description "Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI)"^^xsd:string ;
    a owl:Class ;
    rdfs:label "leuD"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000888491
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "888491"^^xsd:string ;
    obo:OGG_0000000007 "Rv2938"^^xsd:string ;
    obo:OGG_0000000009 "20140322"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 20980199"^^xsd:string ;
    dc:description "Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "By Rebecca Racz and Yongqun He: This gene has a virmugen role. A drrC mutant is highly attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis. Reference: PMID: 14702160." ;
    rdfs:label "drrC"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:OGG_3000888751
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "888751"^^xsd:string ;
    obo:OGG_0000000007 "Rv1221"^^xsd:string ;
    obo:OGG_0000000009 "20140406"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 16513743; 18192397; 18606740; 18657035; 20980199"^^xsd:string ;
    dc:description "Alternative RNA polymerase sigma factor SigE"^^xsd:string ;
    a owl:Class ;
    rdfs:label "sigE"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3000888772
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "888772"^^xsd:string ;
    obo:OGG_0000000007 "Rv0757"^^xsd:string ;
    obo:OGG_0000000009 "20140322"^^xsd:string ;
    obo:OGG_0000000015 "83332"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 9634230; 12368430; 16573683; 18052041; 18065542; 18065544; 18282096; 18757548; 18946503; 19820095; 20363229; 20814030; 20980199; 21634789; 22072719; 22880126"^^xsd:string ;
    dc:description "Possible two component system response transcriptional positive regulator PhoP"^^xsd:string ;
    a owl:Class ;
    rdfs:label "phoP"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060083332 .

obo:OGG_3001197075
    obo:IAO_0000117 "Bin Zhao, Yue Liu, Oliver He"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/gene"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogg.owl> ;
    obo:OGG_0000000006 "1197075"^^xsd:string ;
    obo:OGG_0000000007 "BMEI1364"^^xsd:string ;
    obo:OGG_0000000009 "20140222"^^xsd:string ;
    obo:OGG_0000000015 "224914"^^xsd:string ;
    obo:OGG_0000000017 "I"^^xsd:string ;
    obo:OGG_0000000018 "protein-coding"^^xsd:string ;
    obo:OGG_0000000019 "NCBI-supplied"^^xsd:string ;
    obo:OGG_0000000030 "PMID: 11756688; 12271122; 23161025"^^xsd:string ;
    dc:description "transcriptional regulatory protein MUCR"^^xsd:string ;
    a owl:Class ;
    rdfs:label "BMEI1364"^^xsd:string ;
    rdfs:subClassOf obo:OGG_2060224914 .

obo:OGMS_0000031
    obo:IAO_0000111 "disease" ;
    obo:IAO_0000115 "A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogms.owl> ;
    a owl:Class ;
    rdfs:label "disease" ;
    rdfs:subClassOf obo:BFO_0000016 .

obo:OGMS_0000045
    obo:IAO_0000115 "A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease."@en ;
    obo:IAO_0000117 "Albert Goldfain" ;
    obo:IAO_0000119 "http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf" ;
    obo:IAO_0000232 "creation date: 2009-06-23T11:39:44Z" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ogms.owl> ;
    a owl:Class ;
    rdfs:label "disorder" ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:OGMS_0000060
    obo:IAO_0000117 "Albert Goldfain" ;
    obo:IAO_0000232 "creation date: 2009-06-23T11:53:49Z" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/ogms.owl> ;
    a owl:Class ;
    rdfs:label "bodily process" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:OGMS_0000061
    obo:IAO_0000115 "A bodily process that is clinically abnormal."@en ;
    obo:IAO_0000117 "Albert Goldfain" ;
    obo:IAO_0000119 "http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf" ;
    obo:IAO_0000232 "creation date: 2009-06-23T11:54:29Z" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/oae.owl>, <http://purl.obolibrary.org/obo/ogms.owl> ;
    a owl:Class ;
    rdfs:label "pathological bodily process" ;
    rdfs:subClassOf obo:OGMS_0000060 .

obo:OGMS_0000063
    obo:IAO_0000111 "disease course" ;
    obo:IAO_0000115 "The totality of all processes through which a given disease instance is realized."@en ;
    obo:IAO_0000232 """replace 'OBI:occurrence of disease', need to add logical definition
The axioms of OBI occurence of disease:
Equivalent classes:
realizes some disease
Superclasses:
'has part' some 'pathologic process'
'has participant' some 
    (organism
     and ('has role' some 'host of immune response role'))
biological_process
realizes some 'host of immune response role'"""^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ogms.owl> ;
    a owl:Class ;
    rdfs:label "disease course" ;
    rdfs:subClassOf obo:GO_0008150 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom obo:OGMS_0000031
    ] .

obo:PATO_0000011
    obo:IAO_0000111 "age"@en ;
    obo:IAO_0000115 "A time quality inhering in a bearer by virtue of how long the bearer has existed."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "age"@en ;
    rdfs:subClassOf obo:PATO_0000165 .

obo:PATO_0000044
    obo:IAO_0000111 "frequency"@en ;
    obo:IAO_0000115 "A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "frequency"@en ;
    rdfs:subClassOf obo:PATO_0001018 .

obo:PATO_0000047
    obo:IAO_0000111 "biological sex"@en ;
    obo:IAO_0000115 "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "biological sex"@en ;
    rdfs:subClassOf obo:PATO_0001995 .

obo:PATO_0000165
    obo:IAO_0000111 "time"@en ;
    obo:IAO_0000115 "A quality in which events occur in sequence."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "time"@en ;
    rdfs:subClassOf obo:PATO_0001018 .

obo:PATO_0000169
    obo:IAO_0000111 "viability"@en ;
    obo:IAO_0000115 "An organismal quality inhering in a bearer or a population by virtue of the bearer's ability or inability to survive and develop normally or the number of surviving individuals in a given population."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "viability"@en ;
    rdfs:subClassOf obo:PATO_0001237 .

obo:PATO_0000719
    obo:IAO_0000111 "viable"@en ;
    obo:IAO_0000115 "A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive and develop normally or the long term survival ability of a given population."@en ;
    obo:IAO_0000118 "live" ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "viable"@en ;
    rdfs:subClassOf obo:PATO_0000169 .

obo:PATO_0000918
    obo:IAO_0000111 "volume"@en ;
    obo:IAO_0000115 "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "volume"@en ;
    rdfs:subClassOf obo:PATO_0001237 .

obo:PATO_0001018
    obo:IAO_0000111 "physical quality"@en ;
    obo:IAO_0000115 "A quality of a single physical entity that exists through action of continuants at the physical level of organisation."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "physical quality"@en ;
    rdfs:subClassOf obo:PATO_0001237 .

obo:PATO_0001029
    obo:IAO_0000111 "efficiency"@en ;
    obo:IAO_0000115 "A physical quality inhering in a bearer by virtue of ratio of the bearer's output to the bearer's input."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "efficiency"@en ;
    rdfs:subClassOf obo:PATO_0001018 .

obo:PATO_0001237
    obo:IAO_0000111 "quality of a single physical entity"@en ;
    obo:IAO_0000115 "A physical object quality which inheres in a single-bearer."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "quality of a single physical entity"@en ;
    rdfs:subClassOf obo:PATO_0001241 .

obo:PATO_0001241
    obo:IAO_0000111 "physical object quality"@en ;
    obo:IAO_0000115 "A quality which inheres in a continuant."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "physical object quality"@en ;
    rdfs:subClassOf obo:BFO_0000019 .

obo:PATO_0001422
    obo:IAO_0000111 "dead"@en ;
    obo:IAO_0000115 "A viability quality inhering in a bearer by virtue of the cessation of the bearer's life."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "dead"@en ;
    rdfs:subClassOf obo:PATO_0000169 .

obo:PATO_0001677
    obo:IAO_0000111 "inefficient"@en ;
    obo:IAO_0000115 "An efficiency quality inhering in a bearer by virtue of the bearer's lacking efficiency."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "inefficient"@en ;
    rdfs:subClassOf obo:PATO_0001029 .

obo:PATO_0001678
    obo:IAO_0000111 "efficient"@en ;
    obo:IAO_0000115 "An efficiency quality inhering in a bearer by virtue of the bearer's having efficiency."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "efficient"@en ;
    rdfs:subClassOf obo:PATO_0001029 .

obo:PATO_0001995
    obo:IAO_0000111 "organismal quality"@en ;
    obo:IAO_0000115 "A quality that inheres in an entire organism or part of an organism."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "organismal quality"@en ;
    rdfs:subClassOf obo:PATO_0001237 .

obo:PATO_0002146
    obo:IAO_0000111 "virulence"@en ;
    obo:IAO_0000115 "A quality inhering in a bearer by virtue of the bearer's pathogenicity."@en ;
    obo:IAO_0000412 <http://purl.org/obo/owl/PATO> ;
    a owl:Class ;
    rdfs:label "virulence"@en ;
    rdfs:subClassOf obo:PATO_0001995 .

obo:PRO_000015399
    obo:IAO_0000412 <http://purl.org/obo/owl/PRO> .

obo:PR_000000001
    obo:IAO_0000115 "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl>, <http://purl.org/obo/owl/PRO> ;
    oboInOwl:hasExactSynonym "natural protein"^^xsd:string ;
    oboInOwl:hasNarrowSynonym "native protein"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:id "PR:000000001"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]."^^xsd:string ;
    rdfs:label "protein"^^xsd:string ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:PR_000001096
    obo:IAO_0000115 "A protein with a core domain composition consisting of a signal peptide, an extracellular domain with multiple Leucine rich repeat (Pfam:PF13855) domain (LRR), a cysteine-rich region, a single-pass transmembrane domain and a C-terminal cytoplasmic tail containing a TIR domain (Pfam:PF01582)."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasDbXref "PIRSF:PIRSF800008"^^xsd:string ;
    oboInOwl:hasExactSynonym "fam:TLR"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:id "PR:000001096"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=family."^^xsd:string ;
    rdfs:label "Toll-like receptor"^^xsd:string ;
    rdfs:subClassOf obo:PR_000000001 .

obo:PR_000001153
    obo:IAO_0000115 "A Toll-like receptor that is a translation product of the human TLR2 gene or a 1:1 ortholog thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasDbXref "IUPHARobj:1752"^^xsd:string, "PANTHER:PTHR24365:SF63"^^xsd:string ;
    oboInOwl:hasExactSynonym "CD282"^^xsd:string, "TLR2"^^xsd:string, "Toll/interleukin-1 receptor-like protein 4"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "TIL4"^^xsd:string ;
    oboInOwl:id "PR:000001153"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=gene."^^xsd:string ;
    rdfs:label "Toll-like receptor 2"^^xsd:string ;
    rdfs:subClassOf obo:PR_000001096 .

obo:PR_000001154
    obo:IAO_0000115 "A Toll-like receptor that is a translation product of the human TLR3 gene or a 1:1 ortholog thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasDbXref "IUPHARobj:1753"^^xsd:string, "PANTHER:PTHR24365:SF57"^^xsd:string ;
    oboInOwl:hasExactSynonym "CD283"^^xsd:string, "TLR3"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:id "PR:000001154"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=gene."^^xsd:string ;
    rdfs:label "Toll-like receptor 3"^^xsd:string ;
    rdfs:subClassOf obo:PR_000001096 .

obo:PR_000001155
    obo:IAO_0000115 "A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasBroadSynonym "Toll"^^xsd:string ;
    oboInOwl:hasDbXref "IUPHARobj:1754"^^xsd:string ;
    oboInOwl:hasExactSynonym "CD284"^^xsd:string, "TLR4"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "Lps"^^xsd:string ;
    oboInOwl:id "PR:000001155"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=gene."^^xsd:string ;
    rdfs:label "Toll-like receptor 4"^^xsd:string ;
    rdfs:subClassOf obo:PR_000001096 .

obo:PR_000001158
    obo:IAO_0000115 "A Toll-like receptor that is a translation product of the human TLR7 gene or a 1:1 ortholog thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasDbXref "IUPHARobj:1757"^^xsd:string, "PANTHER:PTHR24365:SF60"^^xsd:string ;
    oboInOwl:hasExactSynonym "TLR7"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "UNQ248/PRO285"^^xsd:string ;
    oboInOwl:id "PR:000001158"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=gene."^^xsd:string ;
    rdfs:label "Toll-like receptor 7"^^xsd:string ;
    rdfs:subClassOf obo:PR_000001096 .

obo:PR_000001159
    obo:IAO_0000115 "A Toll-like receptor that is a translation product of the human TLR8 gene or a 1:1 ortholog thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasDbXref "IUPHARobj:1758"^^xsd:string, "PANTHER:PTHR24365:SF59"^^xsd:string ;
    oboInOwl:hasExactSynonym "CD288"^^xsd:string, "TLR8"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "UNQ249/PRO286"^^xsd:string ;
    oboInOwl:id "PR:000001159"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=gene."^^xsd:string ;
    rdfs:label "Toll-like receptor 8"^^xsd:string ;
    rdfs:subClassOf obo:PR_000001096 .

obo:PR_000011271
    obo:IAO_0000115 "A protein that is a translation product of the human NLRP3 gene or a 1:1 ortholog thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasDbXref "IUPHARobj:1770"^^xsd:string ;
    oboInOwl:hasExactSynonym "CLR1.1"^^xsd:string, "NLRP3"^^xsd:string, "PYRIN-containing APAF1-like protein 1"^^xsd:string, "angiotensin/vasopressin receptor AII/AVP-like"^^xsd:string, "caterpiller protein 1.1"^^xsd:string, "cold autoinflammatory syndrome 1 protein"^^xsd:string, "cold autoinflammatory syndrome 1 protein homolog"^^xsd:string, "cryopyrin"^^xsd:string, "mast cell maturation-associated-inducible protein 1"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "C1orf7"^^xsd:string, "CIAS1"^^xsd:string, "Mmig1"^^xsd:string, "NALP3"^^xsd:string, "PYPAF1"^^xsd:string ;
    oboInOwl:id "PR:000011271"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=gene."^^xsd:string ;
    rdfs:label "NACHT, LRR and PYD domains-containing protein 3"^^xsd:string ;
    rdfs:subClassOf obo:PR_000000001 .

obo:PR_000015399
    obo:IAO_0000115 "A SODC domain protein that is a translation product of the human SOD1 gene or a 1:1 ortholog thereof."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/pr.owl> ;
    oboInOwl:hasExactSynonym "SOD1"^^xsd:string ;
    oboInOwl:hasOBONamespace "protein"^^xsd:string ;
    oboInOwl:id "PR:000015399"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Category=gene."^^xsd:string ;
    rdfs:label "superoxide dismutase [Cu-Zn]"^^xsd:string ;
    rdfs:subClassOf obo:PR_000000001 .

obo:PR_P0DTC2
    a owl:Class ;
    rdfs:label "S protein of SARS-CoV-2 Wuhan strain" ;
    rdfs:subClassOf obo:VO_0004988 .

obo:RO_00000087
    a owl:ObjectProperty .

obo:RO_0000052
    obo:IAO_0000111 "inheres in"@en ;
    obo:IAO_0000112 "this fragility inheres in this vase"@en, "this red color inheres in this apple"@en ;
    obo:IAO_0000115 "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A dependent inheres in its bearer at all times for which the dependent exists."@en ;
    obo:IAO_0000118 "inheres_in"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    a owl:ObjectProperty ;
    rdfs:label "inheres in"@en ;
    rdfs:subPropertyOf obo:RO_0002314 ;
    owl:inverseOf obo:RO_0000053 .

obo:RO_0000053
    obo:IAO_0000111 "bearer of"@en ;
    obo:IAO_0000112 "this apple is bearer of this red color"@en, "this vase is bearer of this fragility"@en ;
    obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist."@en ;
    obo:IAO_0000118 "bearer_of"@en, "is bearer of"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    a owl:ObjectProperty ;
    rdfs:label "bearer of"@en ;
    rdfs:range obo:BFO_0000020 .

obo:RO_0000056
    obo:IAO_0000111 "participates in"@en ;
    obo:IAO_0000112 "this blood clot participates in this blood coagulation"@en, "this input material (or this output material) participates in this process"@en, "this investigator participates in this investigation"@en ;
    obo:IAO_0000115 "a relation between a continuant and a process, in which the continuant is somehow involved in the process"@en ;
    obo:IAO_0000118 "participates_in"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:BFO_0000002 ;
    rdfs:label "participates in"@en ;
    rdfs:range obo:BFO_0000003 ;
    owl:inverseOf obo:RO_0000057 .

obo:RO_0000057
    obo:IAO_0000111 "has participant"@en ;
    obo:IAO_0000112 "this blood coagulation has participant this blood clot"@en, "this investigation has participant this investigator"@en, "this process has participant this input material (or this output material)"@en ;
    obo:IAO_0000115 "a relation between a process and a continuant, in which the continuant is somehow involved in the process"@en ;
    obo:IAO_0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time."@en ;
    obo:IAO_0000118 "has_participant"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    dc:source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:BFO_0000003 ;
    rdfs:label "has participant"@en ;
    rdfs:range obo:BFO_0000002 .

obo:RO_0000059
    obo:IAO_0000112 "A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant)."@en, "An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process)."@en ;
    obo:IAO_0000115 "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:BFO_0000020 ;
    rdfs:label "concretizes"@en ;
    rdfs:range obo:BFO_0000031 .

obo:RO_0000079
    obo:IAO_0000112 "this catalysis function is a function of this enzyme"@en ;
    obo:IAO_0000115 "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists."@en ;
    obo:IAO_0000118 "function_of"@en, "is function of"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "function of"@en ;
    rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000080
    obo:IAO_0000112 "this red color is a quality of this apple"@en ;
    obo:IAO_0000115 "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A quality inheres in its bearer at all times for which the quality exists."@en ;
    obo:IAO_0000118 "is quality of"@en, "quality_of"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "quality of"@en ;
    rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000081
    obo:IAO_0000112 "this investigator role is a role of this person"@en ;
    obo:IAO_0000115 "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists."@en ;
    obo:IAO_0000118 "is role of"@en, "role_of"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "role of"@en ;
    rdfs:subPropertyOf obo:RO_0000052 ;
    owl:inverseOf obo:RO_0000087 .

obo:RO_0000085
    obo:IAO_0000112 "this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)"@en ;
    obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists."@en ;
    obo:IAO_0000118 "has_function"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:BFO_0000004 ;
    rdfs:label "has function"@en ;
    rdfs:range obo:BFO_0000034 ;
    rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0000086
    obo:IAO_0000112 "this apple has quality this red color"@en ;
    obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist."@en ;
    obo:IAO_0000118 "has_quality"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has quality"@en .

obo:RO_0000087
    obo:IAO_0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)"@en ;
    obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000116 "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists."@en ;
    obo:IAO_0000118 "has_role"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:domain obo:BFO_0000004 ;
    rdfs:label "has role", "has role"@en ;
    rdfs:range obo:BFO_0000023 ;
    rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0000091
    obo:IAO_0000115 "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has disposition"@en ;
    rdfs:subPropertyOf obo:RO_0000053 .

obo:RO_0000092
    obo:IAO_0000115 "inverse of has disposition" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty ;
    rdfs:label "disposition of"@en ;
    rdfs:subPropertyOf obo:RO_0000052 .

obo:RO_0000300
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0000301
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0000302
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0001000
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0001020
    obo:IAO_0000112 "penicillin (CHEBI:17334) is allergic trigger for penicillin allergy (DOID:0060520)" ;
    obo:IAO_0000115 "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "is allergic trigger for"@en ;
    rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0001021
    obo:IAO_0000115 "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "is autoimmune trigger for"@en ;
    rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0001022
    obo:IAO_0000112 "penicillin allergy (DOID:0060520) has allergic trigger penicillin (CHEBI:17334)" ;
    obo:IAO_0000115 "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has allergic trigger"@en ;
    rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0001023
    obo:IAO_0000115 "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has autoimmune trigger"@en ;
    rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0001025
    obo:IAO_0000111 "located in"@en ;
    obo:IAO_0000112 "my brain is located in my head"@en, "this rat is located in this cage"@en ;
    obo:IAO_0000115 "a relation between two independent continuants, the target and the location, in which the target is entirely within the location"@en ;
    obo:IAO_0000116 "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1.    Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus"@en, "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime"@en ;
    obo:IAO_0000118 "located_in"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    dc:source "http://www.obofoundry.org/ro/#OBO_REL:located_in" ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:domain obo:BFO_0000004, [
        a owl:Class ;
        owl:intersectionOf (obo:BFO_0000004
            [
                a owl:Class ;
                owl:complementOf obo:BFO_0000006
            ]
        )
    ] ;
    rdfs:label "located in"@en ;
    rdfs:range obo:BFO_0000004, [
        a owl:Class ;
        owl:intersectionOf (obo:BFO_0000004
            [
                a owl:Class ;
                owl:complementOf obo:BFO_0000006
            ]
        )
    ] .

obo:RO_0001900
    obo:IAO_0000115 "An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context." ;
    a owl:AnnotationProperty ;
    rdfs:label "temporal interpretation", "temporal interpretation"@en ;
    rdfs:subPropertyOf obo:RO_0002422 ;
    foaf:page "https://github.com/oborel/obo-relations/wiki/ROAndTime"^^xsd:anyURI .

obo:RO_0001901
    obo:IAO_0000115 """

## Elucidation

This is used when the statement/axiom is assumed to hold true 'eternally'

## How to interpret (informal)

First the \"atemporal\" FOL is derived from the OWL using the standard
interpretation. This axiom is temporalized by embedding the axiom
within a for-all-times quantified sentence. The t argument is added to
all instantiation predicates and predicates that use this relation.

## Example

    Class: nucleus
    SubClassOf: part_of some cell

    forall t :
      forall n :
        instance_of(n,Nucleus,t)
         implies
        exists c :
          instance_of(c,Cell,t)
          part_of(n,c,t)

## Notes

This interpretation is *not* the same as an at-all-times relation

""" ;
    a owl:NamedIndividual ;
    rdfs:label "axiom holds for all times"@en .

obo:RO_0002001
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002009
    obo:IAO_0000115 "A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g." ;
    obo:IAO_0000117 "David Osumi-Sutherland" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    dc:description """x 'cell expresses' y iff:
cell(x)
AND gene(y)
AND exists some 'transcription, DNA templated (GO_0006351)'(t)
AND t occurs_in x
AND t has_input y""" ;
    a owl:ObjectProperty ;
    rdfs:label "cell expresses" ;
    rdfs:subPropertyOf obo:RO_0002292 .

obo:RO_0002010
    obo:IAO_0000115 "x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." ;
    obo:IAO_0000117 "David Osumi-Sutherland" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "regulates in other organism" ;
    rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0002012
    obo:IAO_0000115 "A part of relation that applies only between occurents." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "occurent part of" ;
    rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002418 .

obo:RO_0002013
    obo:IAO_0000115 "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-05-24T09:30:46Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has regulatory component activity" ;
    rdfs:subPropertyOf obo:RO_0002017, obo:RO_0002334 .

obo:RO_0002014
    obo:IAO_0000115 "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-05-24T09:31:01Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:comment "By convention GO molecular functions are classified by their effector function.  Internal regulatory functions are treated as components.  For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'." ;
    rdfs:label "has negative regulatory component activity" ;
    rdfs:subPropertyOf obo:RO_0002013, obo:RO_0002335 .

obo:RO_0002015
    obo:IAO_0000115 "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-05-24T09:31:17Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:comment "By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components.  So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'." ;
    rdfs:label "has positive regulatory component activity" ;
    rdfs:subPropertyOf obo:RO_0002013, obo:RO_0002336 .

obo:RO_0002016
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-05-24T09:36:08Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:comment "A has necessary component activity B if A and B are GO molecular functions  (GO_0003674), A has_component B and B is necessary for A.  For example,  ATPase coupled transporter activity has necessary component ATPase activity; transcript factor activity has necessary component DNA binding activity." ;
    rdfs:label "has necessary component activity" ;
    rdfs:subPropertyOf obo:RO_0002017, obo:RO_0002336 .

obo:RO_0002017
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-05-24T09:44:33Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:comment "A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B." ;
    rdfs:label "has component activity" ;
    rdfs:subPropertyOf obo:RO_0002018 .

obo:RO_0002018
    obo:IAO_0000115 "w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-05-24T09:49:21Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has component process" ;
    rdfs:subPropertyOf obo:RO_0002180 .

obo:RO_0002022
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-09-17T13:52:24Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:comment "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ;
    rdfs:label "directly regulated by" ;
    rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002023
    obo:IAO_0000115 "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-09-17T13:52:38Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "directly negatively regulated by" ;
    rdfs:subPropertyOf obo:RO_0002022 .

obo:RO_0002024
    obo:IAO_0000115 "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-09-17T13:52:47Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "directly positively regulated by" ;
    rdfs:subPropertyOf obo:RO_0002022 .

obo:RO_0002025
    obo:IAO_0000115 "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "dos"^^xsd:string ;
    oboInOwl:creation_date "2017-09-22T14:14:36Z"^^xsd:dateTime ;
    a owl:FunctionalProperty, owl:ObjectProperty ;
    rdfs:comment "This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations." ;
    rdfs:label "has effector activity" ;
    rdfs:subPropertyOf obo:RO_0002017, obo:RO_0002211 .

obo:RO_0002087
    obo:IAO_0000117 "David Osumi-Sutherland" ;
    obo:IAO_0000118 "starts_at_end_of" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:comment "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)"@en ;
    rdfs:label "immediately preceded by"@en .

obo:RO_0002090
    obo:IAO_0000117 "David Osumi-Sutherland" ;
    obo:IAO_0000118 "ends_at_start_of", "meets" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0002575 obo:BFO_0000063 ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:comment "X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)"@en ;
    rdfs:label "immediately precedes"@en ;
    rdfs:subPropertyOf obo:BFO_0000063 .

obo:RO_0002100
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002101
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002102
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002103
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002104
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002110
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002111
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002113
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002120
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002121
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002130
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002131
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "x overlaps y if and only if there exists some z such that x has part z and z part of y" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" ;
    obo:RO_0001900 obo:RO_0001901 ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:label "overlaps"@en ;
    rdfs:subPropertyOf obo:RO_0002323 .

obo:RO_0002132
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002134
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002150
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002151
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002156
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002157
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002158
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002160
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002162
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002163
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002180
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." ;
    obo:IAO_0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." ;
    obo:IAO_0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit."@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:label "has component"@en ;
    rdfs:subPropertyOf obo:BFO_0000051 .

obo:RO_0002200
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." ;
    obo:IAO_0000117 "Chris Mungall"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:label "has phenotype"@en ;
    rdfs:subPropertyOf owl:topObjectProperty .

obo:RO_0002201
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002202
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002203
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002204
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "definition \"x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from x\"" ;
    obo:IAO_0000116 "We would like to be able to express the rule: if t transcribed from g, and t is a noncoding RNA and has an evolved function, then t has gene product g." ;
    obo:IAO_0000117 "Chris Mungall"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "gene product of"@en ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002205
    obo:IAO_0000112 "every HOTAIR lncRNA is the gene product of some HOXC gene", "every sonic hedgehog protein (PR:000014841) is the gene product of some sonic hedgehog gene" ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "x has gene product y if and only if x is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from y" ;
    obo:IAO_0000117 "Chris Mungall"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has gene product"@en ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002206
    obo:IAO_0000112 "'neural crest cell'  SubClassOf expresses some 'Wnt1 gene'" ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" ;
    obo:IAO_0000117 "Chris Mungall"@en ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "expressed in"@en ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002207
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002210
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002211
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2." ;
    obo:IAO_0000116 "We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit" ;
    obo:IAO_0000117 "Chris Mungall", "David Hill", "Tanya Berardini" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations>, "GO" ;
    obo:IAO_0000232 "Regulation precludes parthood; the regulatory process may not be within the regulated process." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "regulates (processual)" ;
    obo:IAO_0000600 false ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "regulates"@en ;
    rdfs:subPropertyOf obo:RO_0002411 .

obo:RO_0002212
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2." ;
    obo:IAO_0000117 "Chris Mungall"@en ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "negatively regulates (process to process)" ;
    obo:RO_0004050 obo:RO_0002211 ;
    a owl:ObjectProperty ;
    rdfs:label "negatively regulates"@en ;
    rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002305 .

obo:RO_0002213
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2." ;
    obo:IAO_0000117 "Chris Mungall"@en ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "positively regulates (process to process)" ;
    obo:RO_0004049 obo:RO_0002211 ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "positively regulates"@en ;
    rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002304 .

obo:RO_0002214
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002215
    obo:IAO_0000112 "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)", "osteoclast SubClassOf 'capable of' some 'bone resorption'" ;
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "has function realized in" ;
    obo:IAO_0000119 <http://www.ncbi.nlm.nih.gov/pubmed/20123131>, <http://www.ncbi.nlm.nih.gov/pubmed/21208450> ;
    obo:IAO_0000232 "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000424 "RO_0000053 some (RO_0000054 only ?Y)" ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:label "capable of"@en ;
    rdfs:subPropertyOf obo:RO_0002216 .

obo:RO_0002216
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "has function in" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000424 "RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))" ;
    a owl:ObjectProperty ;
    rdfs:label "capable of part of"@en ;
    rdfs:subPropertyOf obo:RO_0002328, obo:RO_0002500 .

obo:RO_0002217
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002218
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002219
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002220
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002221
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002222
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002223
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002224
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002225
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002226
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002229
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002230
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002231
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002232
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002233
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002234
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002240
    obo:IAO_0000115 "A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event." ;
    obo:IAO_0000119 "ExO:0000001" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has exposure receptor" ;
    rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002241
    obo:IAO_0000115 "A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event." ;
    obo:IAO_0000119 "ExO:0000000" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has exposure stressor" ;
    rdfs:subPropertyOf obo:RO_0002309 .

obo:RO_0002242
    obo:IAO_0000115 "A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor" ;
    obo:IAO_0000119 "ExO:0000055" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has exposure route" ;
    rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002243
    obo:IAO_0000115 "A broad relationship between an exposure event or process and the course takes from the source to the target." ;
    obo:IAO_0000119 "http://purl.obolibrary.org/obo/ExO_0000004"^^xsd:anyURI ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has exposure transport path" ;
    rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002244
    obo:IAO_0000115 "Any relationship between an exposure event or process and any other entity." ;
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving exposure events or processes." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "related via exposure to" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002245
    obo:IAO_0000115 "g is over-expressed in t iff g is expressed in t, and the expression level of g is increased relative to some background." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "over-expressed in" ;
    rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002246
    obo:IAO_0000115 "g is under-expressed in t iff g is expressed in t, and the expression level of g is decreased relative to some background." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "under-expressed in" ;
    rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002254
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002255
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002256
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002257
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002258
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002260
    obo:IAO_0000115 "c has-biological-role r iff c has-role r and r is a biological role (CHEBI:24432)" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has biological role" ;
    rdfs:subPropertyOf obo:RO_0000087 .

obo:RO_0002261
    obo:IAO_0000115 "c has-application-role r iff c has-role r and r is an application role (CHEBI:33232)" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has application role" ;
    rdfs:subPropertyOf obo:RO_0000087 .

obo:RO_0002262
    obo:IAO_0000115 "c has-chemical-role r iff c has-role r and r is a chemical role (CHEBI:51086)" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has chemical role" ;
    rdfs:subPropertyOf obo:RO_0000087 .

obo:RO_0002263
    obo:IAO_0000112 "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." ;
    obo:IAO_0000115 "c involved in regulation of p if c enables f and f causally upstream of p" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "acts upstream of" ;
    rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0002264
    obo:IAO_0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." ;
    obo:IAO_0000115 "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:hasRelatedSynonym "affects" ;
    a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within" ;
    rdfs:subPropertyOf obo:RO_0002500 .

obo:RO_0002285
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002286
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002287
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002291
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x" ;
    obo:IAO_0000116 "Revisit this term after coordinating with SO/SOM. The domain of this relation should be a sequence, as an instance of a DNA molecule is only expressed in the cell of which it is a part." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "ubiquitously expressed in"@en ;
    rdfs:subPropertyOf obo:RO_0002206 .

obo:RO_0002292
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "Inverse of 'expressed in'" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "expresses"@en ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002293
    obo:IAO_0000114 obo:IAO_0000125 ;
    obo:IAO_0000115 "inverse of ubiquiotously expressed in" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty ;
    rdfs:label "ubiquitously expresses"@en ;
    rdfs:subPropertyOf obo:RO_0002292 .

obo:RO_0002295
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002296
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002297
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002298
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002299
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002300
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002301
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002302
    obo:IAO_0000115 "Inverse of 'is substance that treats'" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    dc:creator "cjm"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty ;
    rdfs:label "is treated by substance" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002303
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0002304
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004049 obo:RO_0002411 ;
    dc:creator "cjm"^^xsd:string ;
    a owl:ObjectProperty ;
    rdfs:comment "holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y" ;
    rdfs:label "causally upstream of, positive effect" ;
    rdfs:subPropertyOf obo:RO_0002411, obo:RO_0004047 .

obo:RO_0002305
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004050 obo:RO_0002411 ;
    dc:creator "cjm"^^xsd:string ;
    a owl:ObjectProperty ;
    rdfs:comment "holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y" ;
    rdfs:label "causally upstream of, negative effect" ;
    rdfs:subPropertyOf obo:RO_0002411, obo:RO_0004046 .

obo:RO_0002309
    obo:IAO_0000115 "A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    dc:contributor "Austin Meier", "Chris Mungall", "Marie Angelique Laporte" ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-06-05T17:35:04Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has exposure stimulus" ;
    rdfs:subPropertyOf obo:RO_0002244 .

obo:RO_0002314
    obo:IAO_0000115 "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." ;
    obo:IAO_0000116 "Because part_of is transitive, inheres in is a sub-relation of inheres in part of" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://www.ncbi.nlm.nih.gov/pubmed/20064205> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    a owl:ObjectProperty ;
    rdfs:label "inheres in part of"@en ;
    rdfs:subPropertyOf obo:RO_0002502 .

obo:RO_0002323
    obo:IAO_0000115 "A mereological relationship or a topological relationship" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0001900 obo:RO_0001901 ;
    a owl:ObjectProperty ;
    rdfs:label "mereotopologically related to"@en .

obo:RO_0002326
    obo:IAO_0000112 "ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity.", "Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity.", "eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to \"ribosome binding\". And all three are part_of an eIF2 complex" ;
    obo:IAO_0000116 """We would like to say

if and only if
 exists c', p'
  c part_of c' and c' capable_of p
   and
  c capable_of p' and p' part_of p
then
 c contributes_to p

However, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction.""" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 "http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to" ;
    obo:IAO_0000232 "In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology. " ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "contributes to"@en ;
    rdfs:subPropertyOf obo:RO_0002216, obo:RO_0002329 .

obo:RO_0002327
    obo:IAO_0000112 "a particular instances of akt-2 enables some instance of protein kinase activity" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "catalyzes", "executes", "has", "is catalyzing", "is executing" ;
    obo:IAO_0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.", "This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "enables"@en ;
    rdfs:subPropertyOf obo:RO_0002215 .

obo:RO_0002328
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "functionally related to"@en .

obo:RO_0002329
    obo:IAO_0000115 "this relation holds between c and p when c is part of some c', and c' is capable of p." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 false ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "part of structure that is capable of"@en ;
    rdfs:subPropertyOf obo:RO_0002328 .

obo:RO_0002330
    obo:IAO_0000115 "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving the genome of an organism" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "genomically related to"@en .

obo:RO_0002331
    obo:IAO_0000115 "c involved_in p if and only if c enables some process p', and p' is part of p" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "actively involved in", "enables part of" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "involved in"@en ;
    rdfs:subPropertyOf obo:RO_0002431 .

obo:RO_0002334
    obo:IAO_0000115 "inverse of regulates" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "regulated by (processual)" ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "regulated by"@en ;
    rdfs:subPropertyOf obo:RO_0002427 .

obo:RO_0002335
    obo:IAO_0000115 "inverse of negatively regulates" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty ;
    rdfs:label "negatively regulated by"@en ;
    rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002336
    obo:IAO_0000115 "inverse of positively regulates" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty ;
    rdfs:label "positively regulated by"@en ;
    rdfs:subPropertyOf obo:RO_0002334 .

obo:RO_0002404
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000115 "inverse of upstream of" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "causally downstream of"@en ;
    rdfs:subPropertyOf obo:BFO_0000062, obo:RO_0002427 .

obo:RO_0002405
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "immediately causally downstream of"@en ;
    rdfs:subPropertyOf obo:RO_0002087, obo:RO_0002404 .

obo:RO_0002406
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000115 "p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "directly positively regulates" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "directly activates (process to process)" ;
    a owl:ObjectProperty ;
    rdfs:label "directly activates"@en ;
    rdfs:subPropertyOf obo:RO_0002629 .

obo:RO_0002407
    obo:IAO_0000115 "p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "indirectly positively regulates" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0002579 obo:RO_0002213 ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "indirectly activates"@en ;
    rdfs:subPropertyOf obo:RO_0002213 .

obo:RO_0002408
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "directly negatively regulates" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "directly inhibits (process to process)" ;
    a owl:ObjectProperty ;
    rdfs:label "directly inhibits"@en ;
    rdfs:subPropertyOf obo:RO_0002630 .

obo:RO_0002409
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "indirectly negatively regulates" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0002579 obo:RO_0002212 ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "indirectly inhibits"@en ;
    rdfs:subPropertyOf obo:RO_0002212 .

obo:RO_0002410
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000115 "This relation groups causal relations between material entities and causal relations between processes" ;
    obo:IAO_0000116 """This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.

To define causal relations in an activity-flow type network, we make use of 3 primitives:

 * Temporal: how do the intervals of the two occurrents relate? 
 * Is the causal relation regulatory?
 * Is the influence positive or negative

The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.

For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.

For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.

Each of these 3 primitives can be composed to yield a cross-product of different relation types.""" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "causally related to"@en ;
    rdfs:subPropertyOf obo:RO_0002609 .

obo:RO_0002411
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000115 "p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "causally upstream of"@en ;
    rdfs:subPropertyOf obo:BFO_0000063, obo:RO_0002418 .

obo:RO_0002412
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000115 "p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p  must be an input of q." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0002575 obo:RO_0002411 ;
    a owl:ObjectProperty ;
    rdfs:label "immediately causally upstream of"@en ;
    rdfs:subPropertyOf obo:RO_0002090, obo:RO_0002411 .

obo:RO_0002413
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000115 "p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c" ;
    obo:IAO_0000116 "This is currently called 'directly provides input for' to be consistent with our terminology where we use 'direct' whenever two occurrents succeed one another directly. We may relabel this simply 'provides input for', as directness is implicit" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "directly provides input for (process to process)" ;
    a owl:ObjectProperty ;
    rdfs:label "directly provides input for"@en ;
    rdfs:subPropertyOf obo:RO_0002412, obo:RO_0002414 .

obo:RO_0002414
    obo:IAO_0000114 obo:IAO_0000428 ;
    obo:IAO_0000115 "transitive form of directly_provides_input_for" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000232 "This is a grouping relation that should probably not be used in annotation. Consider instead the child relation 'directly provides input for' (which may later be relabeled simply to 'provides input for')" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "transitively provides input for (process to process)" ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "transitively provides input for"@en ;
    rdfs:subPropertyOf obo:RO_0002411 .

obo:RO_0002416
    obo:IAO_0000115 "An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL." ;
    a owl:AnnotationProperty ;
    rdfs:label "logical macro assertion", "logical macro assertion"@en ;
    foaf:page "https://github.com/oborel/obo-relations/wiki/ShortcutRelations"^^xsd:anyURI .

obo:RO_0002418
    obo:IAO_0000115 "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." ;
    obo:IAO_0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "influences (processual)" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:hasRelatedSynonym "affects" ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "causally upstream of or within" ;
    rdfs:subPropertyOf obo:RO_0002501 .

obo:RO_0002421
    obo:IAO_0000115 "A logical macro assertion whose domain is an IRI for a property" ;
    a owl:AnnotationProperty ;
    rdfs:label "logical macro assertion on a property", "logical macro assertion on a property"@en ;
    rdfs:subPropertyOf obo:RO_0002416 .

obo:RO_0002422
    obo:IAO_0000115 "Used to annotate object properties to describe a logical meta-property or characteristic of the object property." ;
    a owl:AnnotationProperty ;
    rdfs:label "logical macro assertion on an object property", "logical macro assertion on an object property"@en ;
    rdfs:subPropertyOf obo:RO_0002421 .

obo:RO_0002423
    a owl:AnnotationProperty ;
    rdfs:label "logical macro assertion on an annotation property", "logical macro assertion on an annotation property"@en ;
    rdfs:subPropertyOf obo:RO_0002421 .

obo:RO_0002427
    obo:IAO_0000115 "inverse of causally upstream of or within" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty, owl:TransitiveProperty ;
    rdfs:label "causally downstream of or within" ;
    rdfs:subPropertyOf obo:RO_0002501 .

obo:RO_0002428
    obo:IAO_0000115 "c involved in regulation of p if c is involved in some p' and p' regulates some p" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "involved in regulation of" ;
    rdfs:subPropertyOf obo:RO_0002263, obo:RO_0002431 .

obo:RO_0002429
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004049 obo:RO_0002428 ;
    a owl:ObjectProperty ;
    rdfs:label "involved in positive regulation of" ;
    rdfs:subPropertyOf obo:RO_0002428 .

obo:RO_0002430
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004050 obo:RO_0002428 ;
    a owl:ObjectProperty ;
    rdfs:label "involved in negative regulation of" ;
    rdfs:subPropertyOf obo:RO_0002428 .

obo:RO_0002431
    obo:IAO_0000115 "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "involved in or reguates" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "involved in or involved in regulation of" ;
    rdfs:subPropertyOf obo:RO_0002264, obo:RO_0002328, obo:RO_0002500 .

obo:RO_0002434
    obo:IAO_0000115 "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." ;
    obo:IAO_0000116 "Considering relabeling as 'pairwise interacts with'"^^xsd:anyURI, "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:hasExactSynonym "in pairwise interaction with" ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty, owl:SymmetricProperty ;
    rdfs:label "interacts with" ;
    foaf:page "https://github.com/oborel/obo-relations/wiki/InteractionRelations"^^xsd:anyURI .

obo:RO_0002436
    obo:IAO_0000115 "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "binds", "molecularly binds with" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty, owl:SymmetricProperty ;
    rdfs:label "molecularly interacts with" ;
    rdfs:subPropertyOf obo:RO_0002434 .

obo:RO_0002448
    obo:IAO_0000115 "Holds between molecular entities A and B where A can physically interact with B and in doing so regulates a process that B is capable of.  For example, A and B may be gene products and binding of B by A regulates the kinase activity of B." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:hasExactSynonym "molecularly controls" ;
    a owl:ObjectProperty ;
    rdfs:label "activity directly regulates activity of" ;
    rdfs:subPropertyOf obo:RO_0002436, obo:RO_0002566 .

obo:RO_0002449
    obo:IAO_0000115 "Holds between molecular entities A and B where A can physically interact with B and in doing so negatively regulates a process that B is capable of.  For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "inhibits" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:hasExactSynonym "molecularly decreases activity of" ;
    a owl:ObjectProperty ;
    rdfs:label "activity directly negatively regulates activity of" ;
    rdfs:subPropertyOf obo:RO_0002448 .

obo:RO_0002450
    obo:IAO_0000115 "Holds between molecular entities A and B where A can physically interact with B and in doing so positively regulates a process that B is capable of.  For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000118 "activates" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:hasExactSynonym "molecularly increases activity of" ;
    a owl:ObjectProperty ;
    rdfs:label "activity directly positively regulates activity of" ;
    rdfs:subPropertyOf obo:RO_0002448 .

obo:RO_0002500
    obo:IAO_0000115 "A relationship between a material entity and a process where the material entity has some causal role that influences the process" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "causal agent in process" ;
    rdfs:subPropertyOf obo:RO_0002595 .

obo:RO_0002501
    obo:IAO_0000115 "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "causal relation between processes" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002502
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "depends on" .

obo:RO_0002503
    obo:IAO_0000115 "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" ;
    obo:IAO_0000116 "This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://www.ncbi.nlm.nih.gov/pubmed/20064205> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "towards" ;
    rdfs:subPropertyOf obo:RO_0002502 .

obo:RO_0002506
    obo:IAO_0000116 "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "causal relation between material entities" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002507
    obo:IAO_0000112 "A coral reef environment is determined by a particular coral reef" ;
    obo:IAO_0000115 "s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s." ;
    obo:IAO_0000116 "The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://www.ncbi.nlm.nih.gov/pubmed/24330602> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "determined by (system to material entity)" ;
    dc:creator "Chris Mungall", "Pier Buttigieg" ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:label "determined by" ;
    rdfs:subPropertyOf obo:BFO_0000050, obo:RO_0002509, obo:RO_0002559 .

obo:RO_0002508
    obo:IAO_0000115 "inverse of determined by" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "determines (material entity to system)" ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259>, <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:label "determines" ;
    rdfs:subPropertyOf obo:RO_0002566 .

obo:RO_0002509
    obo:IAO_0000115 "s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#ro-eco> ;
    a owl:ObjectProperty ;
    rdfs:label "determined by part of" ;
    rdfs:subPropertyOf obo:RO_0002131, obo:RO_0002506 .

obo:RO_0002510
    obo:IAO_0000115 "x is transcribed from y if and only if x is synthesized from template y" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "transcribed from" ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002511
    obo:IAO_0000115 "inverse of transcribed from" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/RO_0002259> ;
    a owl:ObjectProperty ;
    rdfs:label "transcribed to" ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002512
    obo:IAO_0000115 "x is the ribosomal translation of y if and only if a ribosome reads x through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces y" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "ribosomal translation of" ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002513
    obo:IAO_0000115 "inverse of ribosomal translation of" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 "http://www.ncbi.nlm.nih.gov/pubmed/20226267"^^xsd:anyURI ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "ribosomally translates to" ;
    rdfs:subPropertyOf obo:RO_0002330 .

obo:RO_0002559
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "causally influenced by (material entity to material entity)" ;
    a owl:ObjectProperty ;
    rdfs:label "causally influenced by" ;
    rdfs:subPropertyOf obo:RO_0002506 .

obo:RO_0002566
    obo:IAO_0000115 "Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "causally influences (material entity to material entity)" ;
    a owl:ObjectProperty ;
    rdfs:label "causally influences" ;
    rdfs:subPropertyOf obo:RO_0002506 .

obo:RO_0002575
    obo:IAO_0000115 "relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y" ;
    obo:IAO_0000116 """The general property hierarchy is:

  \"directly P\" SubPropertyOf \"P\"
  Transitive(P)

Where we have an annotation assertion

  \"directly P\" \"is direct form of\" \"P\"""" ;
    obo:RO_0002423 "If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'" ;
    dc:creator "Chris Mungall" ;
    a owl:AnnotationProperty ;
    rdfs:label "is direct form of" ;
    rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002578
    obo:IAO_0000115 "Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "directly regulates (processual)" ;
    obo:RO_0002575 obo:RO_0002211 ;
    a owl:ObjectProperty ;
    rdfs:label "directly regulates" ;
    rdfs:subPropertyOf obo:RO_0002211, obo:RO_0002412 .

obo:RO_0002579
    obo:IAO_0000115 "relation p is the indirect form of relation q iff p is a subPropertyOf q, and there exists some p' such that p' is the direct form of q, p' o p' -> p, and forall x,y : x q y -> either (1) x p y or (2) x p' y" ;
    dc:creator "Chris Mungall" ;
    a owl:AnnotationProperty ;
    rdfs:label "is indirect form of" ;
    rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0002584
    obo:IAO_0000112 "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" ;
    obo:IAO_0000115 "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "has part structure that is capable of" ;
    rdfs:subPropertyOf obo:RO_0002328, obo:RO_0002595 .

obo:RO_0002595
    obo:IAO_0000115 "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." ;
    obo:IAO_0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ;
    obo:IAO_0000117 "Chris Mungall" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "causal relation between material entity and a process" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002596
    obo:IAO_0000112 "pyrethroid -> growth" ;
    obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a regulates p." ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "capable of regulating" ;
    rdfs:subPropertyOf obo:RO_0002500 .

obo:RO_0002597
    obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "capable of negatively regulating" ;
    rdfs:subPropertyOf obo:RO_0002596 .

obo:RO_0002598
    obo:IAO_0000112 "renin -> arteriolar smooth muscle contraction" ;
    obo:IAO_0000115 "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "capable of positively regulating" ;
    rdfs:subPropertyOf obo:RO_0002596 .

obo:RO_0002599
    obo:IAO_0000112 "pazopanib -> pathological angiogenesis" ;
    obo:IAO_0000115 "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p." ;
    obo:IAO_0000118 "treats" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000232 "The entity c may be a molecular entity with a drug role, or it could be some other entity used in a therapeutic context, such as a hyperbaric chamber." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "capable of inhibiting or preventing pathological process" ;
    rdfs:subPropertyOf obo:RO_0002597 .

obo:RO_0002600
    obo:IAO_0000112 "benzene -> cancer [CHEBI]" ;
    obo:IAO_0000115 "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p." ;
    obo:IAO_0000118 "causes disease" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "capable of upregulating or causing pathological process" ;
    rdfs:subPropertyOf obo:RO_0002598 .

obo:RO_0002606
    obo:IAO_0000115 "c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d." ;
    obo:IAO_0000118 "treats" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "is substance that treats" ;
    rdfs:subPropertyOf obo:RO_0002599 .

obo:RO_0002607
    obo:IAO_0000115 "c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d." ;
    obo:IAO_0000116 "May be ceded to OBI" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "is marker for" ;
    rdfs:subPropertyOf obo:RO_0002610 .

obo:RO_0002608
    obo:IAO_0000115 "Inverse of 'causal agent in process'" ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "process has causal agent" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0002609
    obo:IAO_0000115 "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ;
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "related via dependence to" .

obo:RO_0002610
    obo:IAO_0000115 "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." ;
    obo:IAO_0000232 "Groups both positive and negative correlation" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "correlated with" ;
    rdfs:subPropertyOf obo:RO_0002609 .

obo:RO_0002629
    obo:IAO_0000115 "Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2." ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "directly positively regulates (process to process)" ;
    obo:RO_0004049 obo:RO_0002578 ;
    a owl:ObjectProperty ;
    rdfs:label "directly positively regulates" ;
    rdfs:subPropertyOf obo:RO_0002213, obo:RO_0002578 .

obo:RO_0002630
    obo:IAO_0000115 "Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2." ;
    obo:IAO_0000119 <http://purl.obolibrary.org/obo/ro/docs/causal-relations> ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:IAO_0000589 "directly negatively regulates (process to process)" ;
    obo:RO_0004050 obo:RO_0002578 ;
    a owl:ObjectProperty ;
    rdfs:label "directly negatively regulates" ;
    rdfs:subPropertyOf obo:RO_0002212, obo:RO_0002578 .

obo:RO_0003000
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0003001
    obo:IAO_0000114 obo:IAO_0000125 .

obo:RO_0003002
    obo:IAO_0000115 "Holds between protein a (a transcription factor) and DNA element b if and only if a diminishes the process of transcription of b." ;
    obo:IAO_0000116 "Logical axioms to be added after the relevant branch of GO is MIREOTed in" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "represses expression of" ;
    rdfs:subPropertyOf obo:RO_0002449 .

obo:RO_0003003
    obo:IAO_0000115 "Holds between protein a (a transcription factor) and DNA element b if and only if a activates the process of transcription of b." ;
    obo:IAO_0000116 "Logical axioms to be added after the relevant branch of GO is MIREOTed in" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "increases expression of" ;
    rdfs:subPropertyOf obo:RO_0002450 .

obo:RO_0003302
    obo:IAO_0000112 """The genetic variant 'NM_007294.3(BRCA1):c.110C>A (p.Thr37Lys)' casues or contributes to the disease  'familial breast-ovarian cancer'.

An environment of exposure to arsenic causes or contributes to the phenotype of patchy skin hyperpigmentation, and the disease 'skin cancer'.""" ;
    obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." ;
    obo:IAO_0000116 "Note that relationships of phenotypes to organisms/strains that bear them, or diseases they are manifest in, should continue to use RO:0002200 ! 'has phenotype' and RO:0002201 ! 'phenotype of'." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:comment """Genetic variations can span any level of granularity from a full genome or genotype to an individual gene  or sequence alteration.  These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology).  The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to.

Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.""" ;
    rdfs:label "causes or contributes to condition"@en ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0003303
    obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "causes condition"@en ;
    rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0003304
    obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "contributes to condition"@en ;
    rdfs:subPropertyOf obo:RO_0003302 .

obo:RO_0003305
    obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual." ;
    obo:IAO_0000118 "contributes to expressivity of condition" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "contributes to severity of condition"@en ;
    rdfs:subPropertyOf obo:RO_0003304 .

obo:RO_0003306
    obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." ;
    obo:IAO_0000118 "contributes to penetrance of condition" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "contributes to frequency of condition"@en ;
    rdfs:subPropertyOf obo:RO_0003304 .

obo:RO_0003307
    obo:IAO_0000115 "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." ;
    obo:IAO_0000118 "is preventative for condition" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:comment """Genetic variations can span any level of granularity from a full genome or genotype to an individual gene  or sequence alteration.  These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology).  The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. 

Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.""" ;
    rdfs:label "ameliorates condition"@en ;
    rdfs:subPropertyOf obo:RO_0003305 .

obo:RO_0003308
    obo:IAO_0000115 "A relationship between an entity and a condition (phenotype or disease) with which it exhibits a statistical dependence relationship." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "correlated with condition"@en ;
    rdfs:subPropertyOf obo:RO_0002610 .

obo:RO_0003309
    obo:IAO_0000115 "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "exacerbates condition"@en ;
    rdfs:subPropertyOf obo:RO_0003305 .

obo:RO_0003310
    obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "condition ameliorated by"@en ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0003311
    obo:IAO_0000115 "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty ;
    rdfs:label "condition exacerbated by"@en ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004000
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a more specific relations" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:38:20Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "condition has genetic basis in" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004001
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:45:20Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has material basis in gain of function germline mutation in" ;
    rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004002
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:45:37Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has material basis in loss of function germline mutation in" ;
    rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004003
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:45:54Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has material basis in germline mutation in" ;
    rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004004
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:46:07Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has material basis in somatic mutation in" ;
    rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004005
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:46:26Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has major susceptibility factor" ;
    rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004006
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:46:57Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "has partial material basis in germline mutation in" ;
    rdfs:subPropertyOf obo:RO_0004000 .

obo:RO_0004010
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a more specific relations" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:53:08Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is genetic basis for condition" ;
    rdfs:subPropertyOf obo:RO_0004018 .

obo:RO_0004011
    obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:55:51Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is causal gain of function germline mutation of in" ;
    rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004012
    obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:56:06Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is causal loss of function germline mutation of in" ;
    rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004013
    obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:56:40Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is causal germline mutation in" ;
    rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004014
    obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:57:07Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is causal somatic mutation in" ;
    rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004015
    obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition  and that is necessary but not sufficient to develop the condition[modified from orphanet]." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:57:43Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is causal susceptibility factor for" ;
    rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004016
    obo:IAO_0000115 "Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T02:58:43Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is causal germline mutation partially giving rise to" ;
    rdfs:subPropertyOf obo:RO_0004010 .

obo:RO_0004017
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:20:01Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "realizable has basis in" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004018
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:20:29Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "is basis for realizable" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004019
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:26:47Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease has basis in" ;
    rdfs:subPropertyOf obo:RO_0004017, obo:RO_0004023 .

obo:RO_0004020
    obo:IAO_0000115 "A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:29:32Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease has basis in dysfunction of" ;
    rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004021
    obo:IAO_0000115 "A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:37:52Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease has basis in disruption of" ;
    rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004022
    obo:IAO_0000115 "A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:46:07Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease has basis in feature" ;
    rdfs:subPropertyOf obo:RO_0002200, obo:RO_0004019 .

obo:RO_0004023
    obo:IAO_0000116 "After import upper level from OGMS, make domain more specific." ;
    obo:IAO_0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all of which have a disease as the subject." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:50:54Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "causal relationship with disease as subject" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004024
    obo:IAO_0000115 "A relationship between a disease and a process where the disease process disrupts the execution of the process." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:51:09Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease causes disruption of" ;
    rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004025
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T03:58:20Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease causes dysfunction of" ;
    rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004026
    obo:IAO_0000115 "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." ;
    obo:IAO_0000116 "TODO: complete range axiom once more of CARO has been mireoted in to this ontology" ;
    obo:IAO_0000232 "This relation is intentionally very general, and covers isolated diseases, where the disease is realized as a process occurring in the location, and syndromic diseases, where one or more of the features may be present in that location. Thus any given disease can have multiple locations in the sense defined here." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-11-05T04:06:02Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease has location" ;
    rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004027
    obo:IAO_0000115 "A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-12-26T19:37:31Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease has inflammation site" ;
    rdfs:subPropertyOf obo:RO_0004026 .

obo:RO_0004028
    obo:IAO_0000115 "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-12-26T19:45:49Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "realized in response to stimulus" ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:RO_0004029
    obo:IAO_0000115 "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-12-26T19:50:53Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease has feature" ;
    rdfs:subPropertyOf obo:RO_0004023 .

obo:RO_0004030
    obo:IAO_0000115 "A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2017-12-26T19:58:44Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "disease arises from structure" ;
    rdfs:subPropertyOf obo:RO_0004019 .

obo:RO_0004032
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004049 obo:RO_0002264 ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-01-26T23:49:30Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within, positive effect" ;
    rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0004033
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004050 obo:RO_0002264 ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-01-26T23:49:51Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "acts upstream of or within, negative effect" ;
    rdfs:subPropertyOf obo:RO_0002264 .

obo:RO_0004034
    obo:IAO_0000115 "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004049 obo:RO_0002263 ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-01-26T23:53:14Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "acts upstream of, positive effect" ;
    rdfs:subPropertyOf obo:RO_0002263, obo:RO_0004032 .

obo:RO_0004035
    obo:IAO_0000115 "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004050 obo:RO_0002263 ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-01-26T23:53:22Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "acts upstream of, negative effect" ;
    rdfs:subPropertyOf obo:RO_0002263, obo:RO_0004033 .

obo:RO_0004046
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004050 obo:RO_0002418 ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-03-13T23:55:05Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "causally upstream of or within, negative effect" ;
    rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0004047
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    obo:RO_0004049 obo:RO_0002418 ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-03-13T23:55:19Z"^^xsd:dateTime ;
    a owl:ObjectProperty ;
    rdfs:label "causally upstream of or within, positive effect" ;
    rdfs:subPropertyOf obo:RO_0002418 .

obo:RO_0004048
    obo:IAO_0000115 "Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be \"+\", \"-\" or \"0\"" ;
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-03-13T23:59:29Z"^^xsd:dateTime ;
    a owl:AnnotationProperty ;
    rdfs:label "is directional form of" ;
    rdfs:subPropertyOf obo:RO_0002422 .

obo:RO_0004049
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-03-14T00:03:16Z"^^xsd:dateTime ;
    a owl:AnnotationProperty ;
    rdfs:label "is positive form of" ;
    rdfs:subPropertyOf obo:RO_0004048 .

obo:RO_0004050
    oboInOwl:created_by "cjm"^^xsd:string ;
    oboInOwl:creation_date "2018-03-14T00:03:24Z"^^xsd:dateTime ;
    a owl:AnnotationProperty ;
    rdfs:label "is negative form of" ;
    rdfs:subPropertyOf obo:RO_0004048 .

obo:RO_0009501
    obo:IAO_0000112 "A drought sensitivity trait that inheres in a whole plant is realized in a systemic response process in response to exposure to drought conditions.", "An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut)", "Environmental polymorphism in butterflies: These butterflies have a 'responsivity to day length trait' that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph." ;
    obo:IAO_0000115 "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    dc:contributor "Austin Meier", "Chris Mungall", "David Osumi-Sutherland", "Marie Angelique Laporte" ;
    oboInOwl:hasExactSynonym "triggered by process" ;
    a owl:ObjectProperty ;
    rdfs:label "realized in response to"@en ;
    rdfs:subPropertyOf obo:RO_0002410 .

obo:UBERON_0000004
    obo:IAO_0000115 "The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047]."^^xsd:string, "a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose]."^^xsd:string, "the organ that is specialized for smell and is part of the respiratory system"^^xsd:string ;
    obo:UBPROP_0000008 "the structure of the nose varies across vertebrates. In tetrapods the nose is part of the respiratory system.[PMID:25312359]"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Nose>, <http://linkedlifedata.com/resource/umls/id/C0028429>, <http://www.snomedbrowser.com/Codes/Details/181195007>, "BTO:0000840"^^xsd:string, "CALOHA:TS-2037"^^xsd:string, "EHDAA2:0001274"^^xsd:string, "EHDAA:1502"^^xsd:string, "EMAPA:16542"^^xsd:string, "EV:0100037"^^xsd:string, "EV:0100370"^^xsd:string, "FMA:46472"^^xsd:string, "GAID:77"^^xsd:string, "MA:0000281"^^xsd:string, "MAT:0000139"^^xsd:string, "MESH:D009666"^^xsd:string, "MIAA:0000139"^^xsd:string, "NCIT:C12756"^^xsd:string, "OpenCyc:Mx4rvViCbJwpEbGdrcN5Y29ycA"^^xsd:string, "TAO:0000047"^^xsd:string, "UMLS:C0028429"^^xsd:string, "ZFA:0000047"^^xsd:string, "galen:Nose"^^xsd:string ;
    oboInOwl:hasExactSynonym "nasal sac"^^xsd:string, "nose"^^xsd:string, "peripheral olfactory organ"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "nasus"^^xsd:string, "olfactory apparatus"^^xsd:string, "proboInOwlscis"^^xsd:string ;
    oboInOwl:id "UBERON:0000004"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#major_organ>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "nose"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000061, obo:UBERON_0000062, obo:UBERON_0004121 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/d/d0/Canine-nose.jpg> .

obo:UBERON_0000042
    obo:IAO_0000115 "multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]"^^xsd:string, "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]"^^xsd:string ;
    obo:UBPROP_0000012 "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA."^^xsd:string ;
    dc:contributor <https://github.com/cmungall> ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Serous_membrane>, <http://linkedlifedata.com/resource/umls/id/C0036760>, <http://www.snomedbrowser.com/Codes/Details/362878009>, "FMA:9581"^^xsd:string, "GAID:19"^^xsd:string, "MESH:D012704"^^xsd:string, "NCIT:C13169"^^xsd:string, "TAO:0005425"^^xsd:string, "UMLS:C0036760"^^xsd:string, "ZFA:0005425"^^xsd:string ;
    oboInOwl:hasExactSynonym "tunica serosa"^^xsd:string, "wall of serous sac"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "serosa"^^xsd:string ;
    oboInOwl:id "UBERON:0000042"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "serous membrane"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0004120, obo:UBERON_0010000 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png>, <http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png> .

obo:UBERON_0000061
    obo:IAO_0000115 "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref <http://dbpedia.org/ontology/AnatomicalStructure>, <http://www.snomedbrowser.com/Codes/Details/362889002>, "AAO:0010825"^^xsd:string, "AEO:0000003"^^xsd:string, "BILA:0000003"^^xsd:string, "CARO:0000003"^^xsd:string, "EHDAA2:0003003"^^xsd:string, "EMAPA:0"^^xsd:string, "FBbt:00007001"^^xsd:string, "FMA:305751"^^xsd:string, "FMA:67135"^^xsd:string, "GAID:781"^^xsd:string, "HAO:0000003"^^xsd:string, "MA:0003000"^^xsd:string, "MESH:D000825"^^xsd:string, "TAO:0000037"^^xsd:string, "TGMA:0001823"^^xsd:string, "VHOG:0001759"^^xsd:string, "WBbt:0000100"^^xsd:string, "XAO:0003000"^^xsd:string, "ZFA:0000037"^^xsd:string ;
    oboInOwl:hasExactSynonym "biological structure"^^xsd:string, "connected biological structure"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "UBERON:0000061"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#upper_level> ;
    a owl:Class ;
    rdfs:label "anatomical structure"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0001062 .

obo:UBERON_0000062
    obo:IAO_0000115 "Anatomical structure that performs a specific function or group of functions [WP]."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions."^^xsd:string ;
    obo:UBPROP_0000012 "CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Organ_(anatomy)>, <http://linkedlifedata.com/resource/umls/id/C0178784>, <http://uri.neuinfo.org/nif/nifstd/birnlex_4>, <http://www.snomedbrowser.com/Codes/Details/272625005>, "CARO:0020004"^^xsd:string, "EFO:0000634"^^xsd:string, "EMAPA:35949"^^xsd:string, "ENVO:01000162"^^xsd:string, "FMA:67498"^^xsd:string, "MA:0003001"^^xsd:string, "NCIT:C13018"^^xsd:string, "OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA"^^xsd:string, "OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA"^^xsd:string, "UMLS:C0178784"^^xsd:string, "WBbt:0003760"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "anatomical unit"^^xsd:string, "body organ"^^xsd:string, "element"^^xsd:string ;
    oboInOwl:id "UBERON:0000062"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#upper_level> ;
    a owl:Class ;
    rdfs:label "organ"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0010000 .

obo:UBERON_0000064
    obo:IAO_0000115 "A multicellular structure that is a part of an organ."^^xsd:string ;
    obo:IAO_0000232 "currently defined in a very broad sense, may be replaced by more specific classes in the future"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref <http://uri.neuinfo.org/nif/nifstd/birnlex_16>, <http://www.snomedbrowser.com/Codes/Details/113343008>, <http://www.snomedbrowser.com/Codes/Details/91717005>, "AAO:0011124"^^xsd:string, "EFO:0000635"^^xsd:string, "FMA:82472"^^xsd:string ;
    oboInOwl:hasExactSynonym "cardinal organ part"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "regional part of organ"^^xsd:string ;
    oboInOwl:id "UBERON:0000064"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#non_informative>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#upper_level> ;
    a owl:Class ;
    rdfs:label "organ part"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0010000 .

obo:UBERON_0000165
    obo:IAO_0000115 "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]"^^xsd:string ;
    obo:UBPROP_0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]"^^xsd:string ;
    obo:UBPROP_0000007 "oral"^^xsd:string ;
    obo:UBPROP_0000011 "some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives"^^xsd:string ;
    obo:UBPROP_0000012 "in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Mouth>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/images/lamprey_sucker_rosava_3238889218.jpg>, <http://www.snomedbrowser.com/Codes/Details/21082005>, "AAO:0010355"^^xsd:string, "BTO:0001090"^^xsd:string, "BTO:0004698"^^xsd:string, "CALOHA:TS-1315"^^xsd:string, "EFO:0000825"^^xsd:string, "EHDAA2:0001326"^^xsd:string, "EHDAA:542"^^xsd:string, "EMAPA:16262"^^xsd:string, "FBbt:00003126"^^xsd:string, "FMA:49184"^^xsd:string, "GAID:75"^^xsd:string, "MA:0000341"^^xsd:string, "MA:0002474"^^xsd:string, "MAT:0000038"^^xsd:string, "MESH:D009055"^^xsd:string, "MIAA:0000038"^^xsd:string, "OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA"^^xsd:string, "TADS:0000040"^^xsd:string, "TAO:0000547"^^xsd:string, "TAO:0000590"^^xsd:string, "TGMA:0000131"^^xsd:string, "VHOG:0000280"^^xsd:string, "VHOG:0000812"^^xsd:string, "XAO:0003029"^^xsd:string, "ZFA:0000547"^^xsd:string, "ZFA:0000590"^^xsd:string, "galen:Mouth"^^xsd:string ;
    oboInOwl:hasExactSynonym "regio oralis"^^xsd:string ;
    oboInOwl:hasNarrowSynonym "adult mouth"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "cavital oralis"^^xsd:string, "cavitas oris"^^xsd:string, "cavum oris"^^xsd:string, "mouth cavity"^^xsd:string, "oral region"^^xsd:string, "oral vestibule"^^xsd:string, "rima oris"^^xsd:string, "stoma"^^xsd:string, "stomatodaeum"^^xsd:string, "trophic apparatus"^^xsd:string, "vestibule of mouth"^^xsd:string, "vestibulum oris"^^xsd:string ;
    oboInOwl:id "UBERON:0000165"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#major_organ>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core>, <http://purl.obolibrary.org/obo/uberon#major_organ>, <http://purl.obolibrary.org/obo/uberon#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "mouth"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0004921 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg> .

obo:UBERON_0000465
    obo:IAO_0000111 "material anatomical entity"^^xsd:string ;
    obo:IAO_0000115 "Anatomical entity that has mass."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/uberon.owl> ;
    a owl:Class ;
    rdfs:label "material anatomical entity"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0000481
    obo:IAO_0000111 "multi-tissue structure"^^xsd:string ;
    obo:IAO_0000115 "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/uberon.owl> ;
    a owl:Class ;
    rdfs:label "multi-tissue structure"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000465 .

obo:UBERON_0000945
    obo:IAO_0000115 "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]"^^xsd:string ;
    obo:UBPROP_0000003 "It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]"^^xsd:string ;
    obo:UBPROP_0000008 "We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Stomach>, <http://linkedlifedata.com/resource/umls/id/C0038351>, <http://www.snomedbrowser.com/Codes/Details/181246003>, "AAO:0000579"^^xsd:string, "ANISEED:1235297"^^xsd:string, "BTO:0001307"^^xsd:string, "CALOHA:TS-0980"^^xsd:string, "EFO:0000837"^^xsd:string, "EHDAA2:0001915"^^xsd:string, "EHDAA:2993"^^xsd:string, "EMAPA:17021"^^xsd:string, "EV:0100070"^^xsd:string, "FMA:7148"^^xsd:string, "GAID:293"^^xsd:string, "MA:0000353"^^xsd:string, "MAT:0000051"^^xsd:string, "MESH:A03.492.766"^^xsd:string, "MIAA:0000051"^^xsd:string, "NCIT:C12391"^^xsd:string, "OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA"^^xsd:string, "TAO:0002121"^^xsd:string, "UMLS:C0038351"^^xsd:string, "VHOG:0000408"^^xsd:string, "XAO:0000128"^^xsd:string, "galen:Stomach"^^xsd:string ;
    oboInOwl:hasNarrowSynonym "stomach chamber"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "anterior intestine"^^xsd:string, "gaster"^^xsd:string, "mesenteron"^^xsd:string, "ventriculus"^^xsd:string ;
    oboInOwl:id "UBERON:0000945"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#major_organ>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#organ_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core>, <http://purl.obolibrary.org/obo/uberon#major_organ>, <http://purl.obolibrary.org/obo/uberon#organ_slim>, <http://purl.obolibrary.org/obo/uberon#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "stomach"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0004921 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg> .

obo:UBERON_0001062
    obo:IAO_0000115 "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref <http://linkedlifedata.com/resource/umls/id/C1515976>, <http://uri.neuinfo.org/nif/nifstd/birnlex_6>, "AAO:0010841"^^xsd:string, "AEO:0000000"^^xsd:string, "BILA:0000000"^^xsd:string, "CARO:0000000"^^xsd:string, "EHDAA2:0002229"^^xsd:string, "FBbt:10000000"^^xsd:string, "FBbt_root:00000000"^^xsd:string, "FMA:62955"^^xsd:string, "HAO:0000000"^^xsd:string, "MA:0000001"^^xsd:string, "NCIT:C12219"^^xsd:string, "TAO:0100000"^^xsd:string, "TGMA:0001822"^^xsd:string, "UMLS:C1515976"^^xsd:string, "XAO:0000000"^^xsd:string, "ZFA:0100000"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "UBERON:0001062"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#upper_level> ;
    a owl:Class ;
    rdfs:label "anatomical entity"^^xsd:string ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:UBERON_0001134
    obo:IAO_0000115 "Muscle tissue that consists primarily of skeletal muscle fibers."^^xsd:string ;
    obo:IAO_0000116 "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]"^^xsd:string, "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]"^^xsd:string ;
    obo:UBPROP_0000003 "This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG]"^^xsd:string ;
    dc:contributor <https://github.com/RDruzinsky>, <https://github.com/cmungall>, <https://github.com/dosumis>, <https://github.com/mellybelly> ;
    oboInOwl:hasBroadSynonym "skeletal muscle"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Skeletal_striated_muscle>, <http://linkedlifedata.com/resource/umls/id/C0242692>, <http://www.snomedbrowser.com/Codes/Details/426215008>, "EMAPA:32716"^^xsd:string, "FMA:14069"^^xsd:string, "MA:0002439"^^xsd:string, "NCIT:C13050"^^xsd:string, "UMLS:C0242692"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "skeletal muscle system"^^xsd:string, "somatic muscle"^^xsd:string ;
    oboInOwl:id "UBERON:0001134"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core>, <http://purl.obolibrary.org/obo/uberon#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "skeletal muscle tissue"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0002385 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg> .

obo:UBERON_0001255
    obo:IAO_0000115 "distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]"^^xsd:string, "Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO]"^^xsd:string ;
    obo:UBPROP_0000003 "In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG]"^^xsd:string ;
    obo:UBPROP_0000007 "vesical"^^xsd:string ;
    obo:UBPROP_0000008 "The urinary bladder evolved in tetrapods. Birds to not possess a true urinary bladder, although Palaeognathae have an undifferentiated cloacal outpocketing that serves a similar function[https://github.com/obophenotype/uberon/issues/454]"^^xsd:string ;
    oboInOwl:hasBroadSynonym "bladder"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Urinary_bladder>, <http://linkedlifedata.com/resource/umls/id/C0005682>, <http://www.snomedbrowser.com/Codes/Details/302512001>, "AAO:0000623"^^xsd:string, "BTO:0001418"^^xsd:string, "CALOHA:TS-1090"^^xsd:string, "EFO:0000290"^^xsd:string, "EHDAA2:0000174"^^xsd:string, "EHDAA:9328"^^xsd:string, "EMAPA:18321"^^xsd:string, "EV:0100098"^^xsd:string, "FMA:15900"^^xsd:string, "GAID:0000004"^^xsd:string, "MA:0000380"^^xsd:string, "MAT:0000122"^^xsd:string, "MESH:A05.810.161"^^xsd:string, "MIAA:0000122"^^xsd:string, "NCIT:C12414"^^xsd:string, "OpenCyc:Mx4rvVjMmZwpEbGdrcN5Y29ycA"^^xsd:string, "UMLS:C0005682"^^xsd:string, "VHOG:0000740"^^xsd:string, "XAO:0000154"^^xsd:string, "galen:UrinaryBladder"^^xsd:string ;
    oboInOwl:hasExactSynonym "vesica urinaria"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "urocyst"^^xsd:string, "vesica"^^xsd:string ;
    oboInOwl:id "UBERON:0001255"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#major_organ>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#organ_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#major_organ>, <http://purl.obolibrary.org/obo/uberon#organ_slim>, <http://purl.obolibrary.org/obo/uberon#uberon_slim> ;
    a owl:Class ;
    rdfs:label "urinary bladder"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0004120, obo:UBERON_0018707 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg> .

obo:UBERON_0001638
    obo:IAO_0000115 "Any of the tubular branching vessels that carry blood from the capillaries toward the heart."^^xsd:string ;
    obo:IAO_0000116 "TODO - check with MA - vein vs venous blood vessel"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO]"^^xsd:string ;
    obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]"^^xsd:string ;
    obo:UBPROP_0000007 "venous"^^xsd:string ;
    obo:UBPROP_0000202 obo:FMA_63814 ;
    oboInOwl:hasBroadSynonym "venous subtree"^^xsd:string, "venous vessel"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Vein>, <http://linkedlifedata.com/resource/umls/id/C0042449>, <http://www.snomedbrowser.com/Codes/Details/181367001>, "AAO:0010212"^^xsd:string, "AEO:0000209"^^xsd:string, "BTO:0000234"^^xsd:string, "CALOHA:TS-1108"^^xsd:string, "EFO:0000816"^^xsd:string, "EHDAA2:0003254"^^xsd:string, "EMAPA:35906"^^xsd:string, "EV:0100031"^^xsd:string, "FMA:50723"^^xsd:string, "GAID:492"^^xsd:string, "MA:0000067"^^xsd:string, "MAT:0000037"^^xsd:string, "MESH:D014680"^^xsd:string, "MIAA:0000037"^^xsd:string, "NCIT:C12814"^^xsd:string, "OpenCyc:Mx4rvVjkWpwpEbGdrcN5Y29ycA"^^xsd:string, "TAO:0000082"^^xsd:string, "UMLS:C0042449"^^xsd:string, "VHOG:0001743"^^xsd:string, "XAO:0000115"^^xsd:string, "ZFA:0000082"^^xsd:string, "galen:Vein"^^xsd:string ;
    oboInOwl:hasExactSynonym "venous tree organ part"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "vascular element"^^xsd:string, "vena"^^xsd:string, "venae"^^xsd:string ;
    oboInOwl:id "UBERON:0001638"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core>, <http://purl.obolibrary.org/obo/uberon#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "vein"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0001981 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg> .

obo:UBERON_0001981
    obo:IAO_0000115 "A vessel through which blood circulates in the body."^^xsd:string ;
    obo:IAO_0000116 "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]"^^xsd:string, "Any of the vessels through which blood circulates in the body.[AAO]"^^xsd:string ;
    obo:UBPROP_0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]"^^xsd:string ;
    obo:UBPROP_0000008 "annelids have blood vessels, but this class is not applicable to annelids."^^xsd:string ;
    obo:UBPROP_0000012 "FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX"^^xsd:string ;
    oboInOwl:hasBroadSynonym "vascular element"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Blood_vessel>, <http://linkedlifedata.com/resource/umls/id/C0005847>, <http://uri.neuinfo.org/nif/nifstd/nlx_anat_090901>, <http://www.snomedbrowser.com/Codes/Details/361097006>, "AAO:0011004"^^xsd:string, "AEO:0000207"^^xsd:string, "BTO:0001102"^^xsd:string, "CALOHA:TS-0080"^^xsd:string, "EFO:0000817"^^xsd:string, "EHDAA2:0003252"^^xsd:string, "EHDAA:240"^^xsd:string, "EMAPA:32743"^^xsd:string, "EMAPA:35993"^^xsd:string, "FMA:50722"^^xsd:string, "FMA:63183"^^xsd:string, "GAID:169"^^xsd:string, "MA:0000060"^^xsd:string, "MAT:0000393"^^xsd:string, "MESH:D001808"^^xsd:string, "NCIT:C12679"^^xsd:string, "OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA"^^xsd:string, "TAO:0002137"^^xsd:string, "UMLS:C0005847"^^xsd:string, "VHOG:0001250"^^xsd:string, "XAO:0001011"^^xsd:string, "ZFA:0005314"^^xsd:string ;
    oboInOwl:hasExactSynonym "region of vascular tree organ"^^xsd:string, "vascular tree organ region"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "vas sanguineum"^^xsd:string ;
    oboInOwl:id "UBERON:0001981"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "blood vessel"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0004120, obo:UBERON_0010000 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg> .

obo:UBERON_0002072
    obo:IAO_0000115 "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]"^^xsd:string, "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]."^^xsd:string ;
    obo:UBPROP_0000007 "hypodermal"^^xsd:string, "subcutaneous"^^xsd:string, "subcutaneus"^^xsd:string ;
    obo:UBPROP_0000012 "BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument."^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Hypodermis>, <http://linkedlifedata.com/resource/umls/id/C0278403>, "BTO:0001314"^^xsd:string, "CALOHA:TS-2366"^^xsd:string, "FMA:70544"^^xsd:string, "NCIT:C33645"^^xsd:string, "TAO:0001136"^^xsd:string, "UMLS:C0278403"^^xsd:string, "ZFA:0001136"^^xsd:string ;
    oboInOwl:hasExactSynonym "hypoderm"^^xsd:string, "vertebrate hypodermis"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "sub-tegumental tissue"^^xsd:string, "subcutaneous tissue"^^xsd:string, "subcutis"^^xsd:string, "subtegumental tissue"^^xsd:string, "superficial fascia"^^xsd:string, "tela subcutanea"^^xsd:string ;
    oboInOwl:id "UBERON:0002072"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core>, <http://purl.obolibrary.org/obo/uberon#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "hypodermis"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000064, obo:UBERON_0004120 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg> .

obo:UBERON_0002097
    obo:IAO_0000115 "The organ covering the body that consists of the dermis and epidermis."^^xsd:string ;
    obo:IAO_0000232 "consider 'integumentary system' for invertebrates"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000012 "MA uses the term skin to refer to what is called here: zone of skin"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Skin>, <http://linkedlifedata.com/resource/umls/id/C1123023>, <http://www.snomedbrowser.com/Codes/Details/181469002>, "BTO:0001253"^^xsd:string, "CALOHA:TS-0934"^^xsd:string, "EFO:0000962"^^xsd:string, "EHDAA2:0001844"^^xsd:string, "EMAPA:17525"^^xsd:string, "FMA:7163"^^xsd:string, "MESH:D012867"^^xsd:string, "MFMO:0000099"^^xsd:string, "NCIT:C12470"^^xsd:string, "OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA"^^xsd:string, "UMLS:C1123023"^^xsd:string, "XAO:0000023"^^xsd:string, "galen:Skin"^^xsd:string ;
    oboInOwl:hasExactSynonym "entire skin"^^xsd:string, "skin organ"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "entire integument"^^xsd:string, "integument"^^xsd:string, "integumental organ"^^xsd:string, "pelt"^^xsd:string, "skin"^^xsd:string ;
    oboInOwl:id "UBERON:0002097"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#efo_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#major_organ>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#major_organ>, <http://purl.obolibrary.org/obo/uberon#uberon_slim> ;
    a owl:Class ;
    rdfs:label "skin of body"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000062, obo:UBERON_0004121 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg> .

obo:UBERON_0002358
    obo:IAO_0000111 "peritoneum"^^xsd:string ;
    obo:IAO_0000115 "A serous membrane that lines the peritoneal cavity[VHOG,modified]."^^xsd:string ;
    obo:IAO_0000116 "TODO - in ZFA is_a epithelium"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl>, <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "An epithelium that lines the peritoneal cavity.[TAO]"^^xsd:string, "Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO]"^^xsd:string ;
    obo:UBPROP_0000007 "peritoneal"^^xsd:string ;
    obo:UBPROP_0000012 "todo: check MA/EMAPA."^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Peritoneum>, <http://linkedlifedata.com/resource/umls/id/C0031153>, "AAO:0010814"^^xsd:string, "BTO:0001472"^^xsd:string, "CALOHA:TS-2072"^^xsd:string, "EV:0100087"^^xsd:string, "FMA:9584"^^xsd:string, "GAID:18"^^xsd:string, "MA:0000449"^^xsd:string, "MESH:A01.047.025.600"^^xsd:string, "NCIT:C12770"^^xsd:string, "OpenCyc:Mx4rvjJ72ZwpEbGdrcN5Y29ycA"^^xsd:string, "TAO:0005120"^^xsd:string, "UMLS:C0031153"^^xsd:string, "VHOG:0001257"^^xsd:string, "XAO:0000139"^^xsd:string, "ZFA:0005120"^^xsd:string, "galen:Peritoneum"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "peritonaeum"^^xsd:string ;
    oboInOwl:id "UBERON:0002358"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#pheno_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim>, <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#vertebrate_core>, <http://purl.obolibrary.org/obo/uberon#uberon_slim>, <http://purl.obolibrary.org/obo/uberon#vertebrate_core> ;
    a owl:Class ;
    rdfs:label "peritoneum"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000042, obo:UBERON_0000481 ;
    foaf:depicted_by <http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png> .

obo:UBERON_0002385
    obo:IAO_0000115 "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    obo:UBPROP_0000001 "One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO]"^^xsd:string ;
    oboInOwl:hasDbXref <http://en.wikipedia.org/wiki/Muscle_tissue>, <http://linkedlifedata.com/resource/umls/id/C2328219>, <http://www.snomedbrowser.com/Codes/Details/91727004>, "AAO:0000306"^^xsd:string, "AEO:0000122"^^xsd:string, "CALOHA:TS-0642"^^xsd:string, "EHDAA2:0003122"^^xsd:string, "EMAPA:32715"^^xsd:string, "FMA:9641"^^xsd:string, "MA:0002437"^^xsd:string, "MESH:D009132"^^xsd:string, "NCIT:C12435"^^xsd:string, "UMLS:C2328219"^^xsd:string, "galen:MuscleTissue"^^xsd:string ;
    oboInOwl:hasExactSynonym "muscular tissue"^^xsd:string, "portion of muscle tissue"^^xsd:string, "textus muscularis"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "UBERON:0002385"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#uberon_slim> ;
    a owl:Class ;
    rdfs:comment "Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach."^^xsd:string ;
    rdfs:label "muscle tissue"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0004120, obo:UBERON_0010000 .

obo:UBERON_0004120
    obo:IAO_0000115 "An anatomical structure that develops (entirely or partially) from the mesoderm."^^xsd:string ;
    obo:IAO_0000232 "Grouping term for query purposes"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref "FBbt:00025998"^^xsd:string ;
    oboInOwl:hasExactSynonym "mesodermal derivative"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "UBERON:0004120"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#grouping_class> ;
    a owl:Class ;
    rdfs:label "mesoderm-derived structure"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0004121
    obo:IAO_0000115 "An anatomical structure that develops (entirely or partially) from the ectoderm."^^xsd:string ;
    obo:IAO_0000232 "Grouping term for query purposes"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref "FBbt:00025990"^^xsd:string ;
    oboInOwl:hasExactSynonym "ectodermal deriviative"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "UBERON:0004121"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#grouping_class> ;
    a owl:Class ;
    rdfs:label "ectoderm-derived structure"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0004921
    obo:IAO_0000115 "A proximal-distal subdivision of the digestive tract."^^xsd:string ;
    obo:IAO_0000232 "intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref "FBbt:00100315"^^xsd:string, "FMA:71131"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:hasRelatedSynonym "alimentary system subdivision"^^xsd:string, "intestinal tract"^^xsd:string, "segment of intestinal tract"^^xsd:string, "subdivision of alimentary system"^^xsd:string ;
    oboInOwl:id "UBERON:0004921"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#non_informative> ;
    a owl:Class ;
    rdfs:label "subdivision of digestive tract"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000064 .

obo:UBERON_0010000
    obo:IAO_0000115 "An anatomical structure that has more than one cell as a part."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref "CARO:0010000"^^xsd:string, "FBbt:00100313"^^xsd:string ;
    oboInOwl:hasExactSynonym "multicellular structure"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "UBERON:0010000"^^xsd:string ;
    oboInOwl:inSubset <http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#upper_level> ;
    a owl:Class ;
    rdfs:label "multicellular anatomical structure"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000061 .

obo:UBERON_0018707
    obo:IAO_0000115 "A membranous sac in animals that serves as the receptacle of a liquid or contains gas."^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> ;
    oboInOwl:hasDbXref "BTO:0000123"^^xsd:string ;
    oboInOwl:hasNarrowSynonym "bladder"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "UBERON:0018707"^^xsd:string ;
    a owl:Class ;
    rdfs:label "bladder organ"^^xsd:string ;
    rdfs:subClassOf obo:UBERON_0000061, obo:UBERON_0000062 .

obo:UBPROP_0000001
    obo:IAO_0000115 "An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class."^^xsd:string ;
    oboInOwl:hasDbXref "UBPROP:0000001"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "external_definition"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "external_definition"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:comment "This annotation property may be replaced with an annotation property from an external ontology such as IAO"^^xsd:string ;
    rdfs:label "external_definition"^^xsd:string .

obo:UBPROP_0000003
    obo:IAO_0000115 "Notes on the homology status of this class."^^xsd:string ;
    oboInOwl:hasDbXref "UBPROP:0000003"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "homology_notes"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "homology_notes"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:comment "This annotation property may be replaced with an annotation property from an external ontology such as IAO"^^xsd:string ;
    rdfs:label "homology_notes"^^xsd:string .

obo:UBPROP_0000007
    obo:IAO_0000232 "Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'."^^xsd:string ;
    oboInOwl:hasDbXref "UBPROP:0000007"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "has_relational_adjective"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "has_relational_adjective"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:label "has_relational_adjective"^^xsd:string .

obo:UBPROP_0000008
    obo:IAO_0000115 "Notes on the how instances of this class vary across species."^^xsd:string ;
    oboInOwl:hasDbXref "UBPROP:0000008"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "taxon_notes"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "taxon_notes"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:label "taxon_notes"^^xsd:string .

obo:UBPROP_0000011
    obo:IAO_0000115 "Notes on the ontogenic development of instances of this class."^^xsd:string ;
    obo:IAO_0000116 "This annotation property may be replaced with an annotation property from an external ontology such as IAO"^^xsd:string ;
    oboInOwl:hasDbXref "UBPROP:0000011"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "development_notes"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "development_notes"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:label "development_notes"^^xsd:string .

obo:UBPROP_0000012
    obo:IAO_0000115 "Notes on how similar or equivalent classes are represented in other ontologies."^^xsd:string ;
    obo:IAO_0000116 "This annotation property may be replaced with an annotation property from an external ontology such as IAO"^^xsd:string ;
    oboInOwl:hasDbXref "UBPROP:0000012"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "external_ontology_notes"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "external_ontology_notes"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:label "external_ontology_notes"^^xsd:string .

obo:UBPROP_0000202
    obo:UBPROP_0000012 "FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term"^^xsd:string ;
    oboInOwl:hasDbXref "UBPROP:0000202"^^xsd:string ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "fma_set_term"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "fma_set_term"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:label "fma_set_term"^^xsd:string .

obo:UO_0000098
    obo:IAO_0000115 "A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter."^^xsd:string ;
    obo:IAO_0000118 "ml"^^xsd:string ;
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uo.owl> ;
    a owl:Class ;
    rdfs:label "milliliter"^^xsd:string ;
    rdfs:subClassOf obo:IAO_0000003 .

obo:VO_0000000
    obo:IAO_0000115 "'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "part of pathogen organism in vaccine" ;
    rdfs:subClassOf obo:VO_0000420 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000420
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000050 ;
                owl:someValuesFrom obo:OBI_0100026
            ]
        )
    ] .

obo:VO_0000001
    obo:IAO_0000115 "A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine." ;
    obo:IAO_0000116 "Many vaccines are developed to protect against infectious pathogens that causes infectious diseases. Many vaccines are also being developed against other diseases such as cancer, allergy, and autoimmune diseases." ;
    obo:IAO_0000117 "YH, BP, BS, MC, LC, XZ, RS", "a role that inheres in a prepared material entity that is designed to induce protection or treament for a diease or infection in vivo." ;
    a owl:Class ;
    rdfs:label "vaccine" ;
    rdfs:seeAlso "MeSH: D014612" ;
    rdfs:subClassOf obo:OBI_0000047 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:OBI_0000047
            [
                a owl:Restriction ;
                owl:onProperty obo:OBI_0000312 ;
                owl:someValuesFrom obo:VO_0000590
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000085 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:VO_0000278
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:BFO_0000054 ;
                            owl:someValuesFrom obo:VO_0000494
                        ]
                    )
                ]
            ]
        )
    ] .

obo:VO_0000002
    obo:IAO_0000115 "a process of administering substance in vivo that involves in adding a vaccine into a host (e.g., human) in vivo with the intent to invoke a protective or therapeutic adaptive immune response." ;
    obo:IAO_0000117 "YH, BP" ;
    obo:IAO_0000118 "vaccine administration" ;
    a owl:Class ;
    rdfs:label "vaccination" ;
    rdfs:subClassOf obo:OBI_0600007, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000057 ;
        owl:someValuesFrom obo:VO_0000001
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000057 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:OBI_0100026
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:VO_0001274
                ]
            )
        ]
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:OBI_0600007
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:OBI_0000319
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000081 ;
                            owl:someValuesFrom obo:VO_0000001
                        ]
                    )
                ]
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000055 ;
                owl:someValuesFrom [
                    a owl:Class ;
                    owl:intersectionOf (obo:OBI_0000444
                        [
                            a owl:Restriction ;
                            owl:onProperty obo:RO_0000081 ;
                            owl:someValuesFrom obo:OBI_0100026
                        ]
                    )
                ]
            ]
        )
    ] .

obo:VO_0000003
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/833083", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm180810.htm"^^xsd:anyURI ;
    obo:VO_0003099 "ACAM2000"^^xsd:anyURI ;
    obo:VO_0003158 "Smallpox (Vaccinia) Vaccine, Live"^^xsd:anyURI ;
    obo:VO_0003159 "Emergent Product Development Gaithersburg, Inc."^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization against smallpox disease for persons determined to be at high risk for smallpox infection."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125158"^^xsd:anyURI ;
    obo:VO_0003198 833083 ;
    a owl:Class ;
    rdfs:label "ACAM2000" ;
    rdfs:seeAlso "CVX: 75" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004854
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003052
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000686 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000004
    obo:IAO_0000116 """Preparation: The vaccine consists of the Haemophilus b capsular polysaccharide (polyribosyl-ribitol-phosphate, PRP), a high molecular weight polymer prepared from the Haemophilus influenzae  type b (HiB) strain 1482 grown in a semi-synthetic medium, covalently bound to tetanus toxoid. The tetanus toxoid is prepared by extraction, ammonium sulfate purification, and formalin inactivation of the toxin from cultures of Clostridium tetani (Harvard strain) grown in a modified Mueller and Miller medium. The toxoid is filter sterilized prior to the conjugation process. When ActHIB vaccine is reconstituted with saline diluent, each single dose of 0.5 mL is formulated to contain 10 mu g of purified capsular polysaccharide conjugated to 24 mu g of inactivated tetanus toxoid, and 8.5% of sucrose (ActHIB 2005). 
Reference: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=157&keywords=""" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm174743.htm" ;
    obo:VO_0003099 "ActHIB" ;
    obo:VO_0003158 "Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)" ;
    obo:VO_0003159 "Sanofi Pasteur, SA" ;
    obo:VO_0003160 "ActHIB vaccine is indicated for the active immunization of infants and children 2 months through 5 years of age for the prevention of invasive disease caused by H influenzae type b." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf" ;
    obo:VO_0003162 103935 ;
    a owl:Class ;
    rdfs:label "ActHIB" ;
    rdfs:seeAlso "CVX: 48", "PMID:", "PMID: 1517908", "PMID: 1735812" ;
    rdfs:subClassOf obo:VO_0000662, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001254
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000703 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000005
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/605718", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm172481.htm" ;
    obo:VO_0003099 "Adacel" ;
    obo:VO_0003158 "Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed" ;
    obo:VO_0003159 "Sanofi Pasteur, Ltd" ;
    obo:VO_0003160 "Booster immunization against tetanus, diphtheria and pertussis as a single dose in individuals 10 through 64 years of age." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf" ;
    obo:VO_0003162 "BL 125111" ;
    obo:VO_0003198 605718 ;
    a owl:Class ;
    rdfs:label "Adacel" ;
    rdfs:seeAlso "CVX: 115", "CVX: 20" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003201
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003202
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000006
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094043.htm" ;
    obo:VO_0003099 "AFLURIA" ;
    obo:VO_0003158 "Influenza Virus Vaccine" ;
    obo:VO_0003159 "Seqirus Pty. Ltd" ;
    obo:VO_0003160 "For active immunization of persons ages 6 months of age and older against influenza disease caused by influenza virus subtypes A and type B present in the vaccine." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf" ;
    obo:VO_0003162 "BL 125254" ;
    a owl:Class ;
    rdfs:label "Afluria" ;
    rdfs:seeAlso "CVX: 140", "CVX: 141" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000270 ;
        owl:someValuesFrom obo:VO_0000218
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000689 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:VO_0000908
    ] .

obo:VO_0000007
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Measles Virus Vaccine, Live"^^xsd:string, "Trade Name: Attenuvax" ;
    rdfs:label "Attenuvax" ;
    rdfs:subClassOf obo:VO_0000654, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000008
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced lymphocyte activation" ;
    rdfs:subClassOf obo:VO_0000361 .

obo:VO_0000009
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced B cell antigen processing and presentation" ;
    rdfs:subClassOf obo:VO_0000012 .

obo:VO_0000010
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced B cell cytokine production" ;
    rdfs:subClassOf obo:VO_0000012 .

obo:VO_0000011
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B cell epitope in vaccine" ;
    a owl:Class ;
    rdfs:label "vaccine B cell epitope" ;
    rdfs:subClassOf obo:VO_0000811 .

obo:VO_0000012
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced B cell mediated immunity" ;
    rdfs:subClassOf obo:VO_0000135 .

obo:VO_0000013
    obo:IAO_0000115 "A vaccine that protects against Bacillus anthrax that causes anthrax." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "anthrax vaccine" ;
    a owl:Class ;
    rdfs:label "Bacillus anthracis vaccine" ;
    rdfs:seeAlso "MeSH: D022122" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0000014
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/404894", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm133822.htm" ;
    obo:VO_0003099 "Biothrax" ;
    obo:VO_0003158 "Anthrax Vaccine Adsorbed" ;
    obo:VO_0003159 "Emergent BioDefense Operations Lansing LLC" ;
    obo:VO_0003160 "For the active immunization for the prevention of disease caused by Bacillus anthracis in persons between 18 and 65 years of age at high risk of exposure." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf" ;
    obo:VO_0003162 "BL 103821" ;
    obo:VO_0003198 404894 ;
    a owl:Class ;
    rdfs:label "Biothrax" ;
    rdfs:seeAlso "CVX: 24" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004208
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000688 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000015
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/583411", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm172925.htm" ;
    obo:VO_0003099 "Boostrix" ;
    obo:VO_0003158 "Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "Booster immunization against tetanus, diphtheria and pertussis as a single dose in individuals 10 years of age and older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf" ;
    obo:VO_0003162 "BL 125106" ;
    obo:VO_0003198 583411 ;
    a owl:Class ;
    rdfs:label "Boostrix" ;
    rdfs:seeAlso "CVX: 115", "CVX: 20" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003201
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000016
    obo:IAO_0000115 "a type of 'has vaccine component' relation that specifies a vaccine conjugate protein for a specific vaccine" ;
    a owl:ObjectProperty ;
    rdfs:label "has vaccine conjugate protein"@en ;
    rdfs:subPropertyOf obo:VO_0000520 .

obo:VO_0000017
    obo:IAO_0000115 "whole organism vaccine that uses killed pathogen organism as its component." ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "killed vaccine" ;
    rdfs:subClassOf obo:VO_0000315, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0000018
    obo:IAO_0000115 "A Brucella abortus vaccine that expresses Cu/Zn SOD with DNA plasmid pcDNA. PMID: 15039330." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus DNA vaccine pcDNA-SOD" ;
    rdfs:seeAlso "PMID: 15039330" ;
    rdfs:subClassOf obo:VO_0001225, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000208
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0000154
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000019
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pVAX DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000020
    obo:IAO_0000115 "a bacterial vaccine vector that uses B. abortus vaccine strain RB51 as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus strain RB51 vaccine vector" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0000021
    obo:IAO_0000115 "Brucella abortus vaccine RB51 is a Brucella abortus vaccine that is licensed in the USA since 1992."^^xsd:string ;
    obo:IAO_0000116 "Brucella abortus vaccine RB51 is a live attenuated cattle vaccine against brucellosis that is currently used in the USA and many other coutries."^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus RB51", "Brucella RB-51", "Brucella RB51", "SRB51" ;
    a owl:Class ;
    rdfs:label "Brucella abortus vaccine RB51" ;
    rdfs:seeAlso "PMID: 10534009", "PMID: 11193615", "PMID: 11500423", "PMID: 11504226", "PMID: 11504238", "PMID: 11553603", "PMID: 11768128", "PMID: 12119140", "PMID: 12438380", "PMID: 12704101", "PMID: 1439207", "PMID: 16713034", "PMID: 17653832", "PMID: 17894637", "PMID: 18836016", "PMID: 1908158", "PMID: 19362381", "PMID: 19439382", "PMID: 7622248", "PMID: 7806364", "PMID: 7927779", "PMID: 8039890", "PMID: 8740701", "PMID: 8890203", "WEB: http://rb51.com" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000799 ;
        owl:someValuesFrom obo:VO_0000794
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_391902
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9901
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:activates ;
        owl:someValuesFrom obo:VO_0000100
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000022
    obo:IAO_0000115 "A live attenuated Brucella abortus vaccine that is licensed and used in many countries." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Brucella S19", "Brucella strain-19" ;
    a owl:Class ;
    rdfs:label "Brucella abortus vaccine strain 19" ;
    rdfs:seeAlso "PMID: 11058778", "PMID: 8039890" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0000023
    obo:IAO_0000117 "YH, ZX" ;
    oboInOwl:hasURI "http://www.invitrogen.com" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Invitrogen"@en .

obo:VO_0000024
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pVAX1 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000025
    obo:IAO_0000115 "A vaccine that protects against Brucella that causes brucellosis in animals and humans." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "brucellosis vaccine" ;
    a owl:Class ;
    rdfs:label "Brucella vaccine" ;
    rdfs:seeAlso "MeSH: D002004" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0000026
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV4 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000027
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pAp031 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000028
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/139056" ;
    obo:VO_0003198 139056 ;
    a owl:Class ;
    rdfs:comment "Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant)"^^xsd:string, "Trade Name: Comvax" ;
    rdfs:label "Comvax" ;
    rdfs:seeAlso "CVX: 51", "PMID:" ;
    rdfs:subClassOf obo:VO_0000746, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003150
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003408
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000029
    obo:IAO_0000116 "Vaccine components see http://www.vaccinesafety.edu/components-DTaP.htm" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/352572", "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf" ;
    obo:VO_0003099 "DAPTACEL" ;
    obo:VO_0003158 "Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed" ;
    obo:VO_0003159 "Sanofi Pasteur, Ltd." ;
    obo:VO_0003160 "Indicated for active immunization against diphtheria, tetanus and pertussis as a five dose series in infants and children 6 weeks through 6 years of age (prior to 7th birthday)." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf" ;
    obo:VO_0003162 103666 ;
    obo:VO_0003198 352572 ;
    a owl:Class ;
    rdfs:label "Daptacel" ;
    rdfs:seeAlso "CVX: 106", "CVX: 20" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003201
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003202
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000030
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use"^^xsd:string, "Trade Name: DECAVAC" ;
    rdfs:label "DECAVAC" ;
    rdfs:seeAlso "CVX: 113" ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000031
    obo:IAO_0000115 "a vaccine for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups C and Y and Haemophilus influenzae type b. MENHIBRIX is approved for use in children 6 weeks of age through 18 months of age. " ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1437912", "https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm308566.htm"^^xsd:anyURI ;
    obo:VO_0003099 "MenHibrix"^^xsd:anyURI ;
    obo:VO_0003158 "Meningococcal Groups C and Y and Haemophilus b Tetanus Toxoid Conjugate Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals"^^xsd:anyURI ;
    obo:VO_0003160 "Indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups C and Y and Haemophilus influenzae type b for children 6 weeks of age through 18 months of age."^^xsd:anyURI ;
    obo:VO_0003162 "BL 125363/0"^^xsd:anyURI ;
    obo:VO_0003198 1437912 ;
    a owl:Class ;
    rdfs:label "MenHibrix"@en ;
    rdfs:subClassOf [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000053
            obo:VO_0000662
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004859
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004860
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015013
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000032
    obo:IAO_0000115 "DNA vaccine is a vaccine that is composed of a plasmid vaccine vector (a circular double stranded DNA molecule) containing genes encoding one or more proteins of a pathogen." ;
    obo:IAO_0000116 "synonym: naked DNA vaccine"^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "genetic vaccine", "naked DNA vaccine", "nucleic acid vaccine" ;
    a owl:Class ;
    rdfs:label "DNA vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000623
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000623
    ] .

obo:VO_0000033
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Diphtheria & Tetanus Toxoids Adsorbed"^^xsd:string ;
    rdfs:label "Diphtheria and Tetanus Toxoids Adsorbed USP by Sanofi Pasteur Inc" ;
    rdfs:seeAlso "CVX: 28" ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000034
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Diphtheria & Tetanus Toxoids Adsorbed"^^xsd:string, "This term is obsolete since there is another term with the same meaning." ;
    rdfs:label "OBSOLETE - Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd" ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0000035
    obo:IAO_0000115 "a vaccinia virus vaccine that is a freeze-dried calf lymph smallpox vaccine, specifically, Dryvax is a live-virus preparation of vaccinia prepared from calf lymph. " ;
    obo:IAO_0000116 "Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been eradicated from nature in 1980, Wyeth stopped making the vaccine." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "http://en.wikipedia.org/wiki/Dryvax" ;
    a owl:Class ;
    rdfs:comment "Product Name: Smallpox Vaccine, Dried, Calf Lymph Type"^^xsd:string, "Trade Name: Dryvax" ;
    rdfs:label "Dryvax" ;
    rdfs:seeAlso "CVX: 75" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000036
    obo:IAO_0000116 "ACAM2007 is a vaccine candidate expressing CFA/II." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095642/" ;
    a owl:Class ;
    rdfs:label "ETEC vaccine ACAM2010" ;
    rdfs:seeAlso "PMID: 17566016" ;
    rdfs:subClassOf obo:VO_0000619, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000037
    obo:IAO_0000115 "A viral vaccine that protects against infection of an adenovirus." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "adenovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10508
    ] .

obo:VO_0000038
    obo:IAO_0000115 "An assay that measures the persistent survival of live vaccine in a host in vivo." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine persistence assay" ;
    rdfs:subClassOf obo:OBI_0000070 .

obo:VO_0000039
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pBacPAK9 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000040
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pBC12/CMV DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000041
    obo:IAO_0000115 "A bacterial vaccine that prevents against Escherichia coli infection." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "E. coli vaccine" ;
    a owl:Class ;
    rdfs:label "Escherichia coli vaccine" ;
    rdfs:seeAlso "MeSH: D022361" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_562
    ] .

obo:VO_0000042
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pBHT DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000043
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm112845.htm"^^xsd:anyURI ;
    obo:VO_0003099 "FluLaval"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza Virus Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "ID Biomedical Corporation of Quebec"^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization for the prevention of disease caused by influenza A subtype viruses and type B virus contained in the vaccine. FLULAVAL is approved for use in persons 6 months of age and older."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125163"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza Virus Vaccine, Trivalent, Types A and B"^^xsd:string ;
    rdfs:label "FluLaval" ;
    rdfs:seeAlso "CVX: 141" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0002498 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000044
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094047.htm"^^xsd:anyURI ;
    obo:VO_0003099 "FluMist"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza Vaccine Live, Intranasal"^^xsd:anyURI ;
    obo:VO_0003159 "MedImmune, LLC"^^xsd:anyURI ;
    obo:VO_0003160 "For the active immunization of individuals 2-49 years of age against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine."^^xsd:anyURI ;
    obo:VO_0003162 "BL 125020"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "FluMist" ;
    rdfs:seeAlso "CVX: 111" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000343
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000694 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000045
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm112850.htm" ;
    obo:VO_0003099 "Fluarix" ;
    obo:VO_0003158 "Influenza Virus Vaccine" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "For active immunization of persons 3 years of age and older for the prevention of disease caused by influenza virus subtypes A and type B contained in the vaccine." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf" ;
    obo:VO_0003162 "BL 125127" ;
    a owl:Class ;
    rdfs:label "Fluarix" ;
    rdfs:seeAlso "CVX: 140" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000046
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm112852.htm" ;
    obo:VO_0003099 "Fluvirin" ;
    obo:VO_0003158 "Influenza Virus Vaccine" ;
    obo:VO_0003159 "Seqirus Vaccines Limited" ;
    obo:VO_0003160 "For active immunization of persons 4 years of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123694.pdf" ;
    obo:VO_0003162 "BL 103837" ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza Virus Vaccine, Trivalent, Types A and B"^^xsd:string ;
    rdfs:label "Fluvirin" ;
    rdfs:seeAlso "CVX: 140", "CVX: 141" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000696 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000047
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm112854.htm" ;
    obo:VO_0003099 "Fluzone" ;
    obo:VO_0003158 "Influenza Virus Vaccine" ;
    obo:VO_0003160 "Fluzone is indicated for active immunization of persons 6 months of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM619664.pdf" ;
    obo:VO_0003162 "BL 103914" ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza Virus Vaccine, Trivalent, Types A and B"^^xsd:string ;
    rdfs:label "Fluzone" ;
    rdfs:seeAlso "CVX: 140", "CVX: 141", "CVX: 144" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000048
    obo:IAO_0000115 "a gene that once deleted, would make an attenuated microbe that can be used as a live attenuated vaccine against virulent pathogen." ;
    obo:IAO_0000117 "YH, YL, ZX" ;
    a owl:Class ;
    rdfs:label "virmugen" ;
    rdfs:subClassOf obo:OGG_0000000002 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0000049
    obo:IAO_0000116 """Gardasil is a quadrivalent vaccine meaning it protects against 4 strains of virus (types 6, 11, 16, and 18). The vaccine was made using genetic engineering techniques. The genes that encode a specific protein from each of these strains are expressed in yeast in large-scale fermentation cultures. Protein purification methods are then used to isolate the proteins and make the vaccine.
Cited from: 
http://biotech.about.com/b/2008/09/03/gardasil-safety-of-genetically-engineered-hpv-vaccine-still-in-question.htm""" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/659877", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094042.htm" ;
    obo:VO_0003099 "Gardasil" ;
    obo:VO_0003158 "Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant" ;
    obo:VO_0003159 "Merck & Co., Inc" ;
    obo:VO_0003160 """- Prevention of vulvar and vaginal cancer
- Vaccination in females 9 through 26 years of age for prevention of the following diseases caused by Human Papillomavirus (HPV) Types 6, 11, 16, and 18:
     - Cervical Cancer
     - Genital warts (condyloma acuminata) and the following precancerous or dysplastic lesions:
          - Cervical adenocarcinoma in situ (AIS)cancer
          - Cervical intraepithelial neoplasia (CIN) grade 2 and grade 3
          - Vulvar intraepithelial neoplasia (VIN) grade 2 and grade 3
          - Vaginal intraepithelial neoplasia (VaIN) grade 2 and grade 3
          - Cervical intraepithelial neoplasia (CIN) grade 1
- Vaccination in boys and men 9 through 26 years of age for the prevention of genital warts caused by HPV types 6 and 11
- Vaccination in people ages 9 through 26 years for the prevention of anal cancer and associated precancerous lesions due to human papillomavirus (HPV) types 6, 11, 16, and 18""" ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf" ;
    obo:VO_0003162 125126 ;
    obo:VO_0003198 659877 ;
    a owl:Class ;
    rdfs:label "Gardasil" ;
    rdfs:seeAlso "CVX: 62" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003300
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003301
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003302
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003303
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000050
    obo:IAO_0000115 "a lentivirus vaccine vector that uses a HIV strain as the vector" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "HIV based lentivirus vaccine vector" ;
    rdfs:subClassOf obo:VO_0000359 .

obo:VO_0000051
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Balb/c mouse" ;
    rdfs:subClassOf obo:NCBITaxon_10090 .

obo:VO_0000052
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/203439", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm110016.htm" ;
    obo:VO_0003099 "HAVRIX" ;
    obo:VO_0003158 "Hepatitis A Vaccine, Inactivated" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "For active immunization against disease caused by hepatitis A virus (HAV) for persons 12 months of age and older." ;
    obo:VO_0003161 "BL 103475", "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf" ;
    obo:VO_0003198 203439 ;
    a owl:Class ;
    rdfs:label "Havrix" ;
    rdfs:seeAlso "CVX: 52", "CVX: 83" ;
    rdfs:subClassOf obo:VO_0000646, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003433
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000053
    obo:IAO_0000115 "A bacterial vaccine that prevents Neisseria meningitidis infection." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Meningococcal vaccine" ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis vaccine" ;
    rdfs:seeAlso "MeSH: D022401" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000165
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_487
            ]
        )
    ] .

obo:VO_0000054
    obo:IAO_0000115 "IPOL, Poliovirus Vaccine Inactivated is a sterile suspension of three types of poliovirus: Type 1 (Mahoney), Type 2 (MEF-1), and Type 3 (Saukett). IPOL vaccine is a highly purified, inactivated poliovirus vaccine with enhanced potency." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/287617", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm180053.htm" ;
    obo:VO_0003099 "IPOL" ;
    obo:VO_0003158 "Poliovirus Vaccine Inactivated (Monkey Kidney Cell)" ;
    obo:VO_0003159 "Sanofi Pasteur, SA" ;
    obo:VO_0003160 "IPOL vaccine is indicated for active immunization of infants (as young as 6 weeks of age), children and adults for the prevention of poliomyelitis caused by poliovirus Types 1, 2, and 3." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf" ;
    obo:VO_0003162 103930 ;
    obo:VO_0003198 287617 ;
    a owl:Class ;
    rdfs:label "IPOL" ;
    rdfs:seeAlso "CVX: 10", "PMID:" ;
    rdfs:subClassOf obo:VO_0000664, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003836
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003837
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000703 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000055
    obo:IAO_0000115 "The jourmal article that mentions a vaccine, which was retrieved from PubMed and annotated using VO-SciMinner.(Hur J, Xiang Z, Feldman EL, He Y. Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network. BMC Immunology. 12(1):49 2011 Aug 26. PMID: 21871085.)"@en ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "vaccine related journal article" ;
    rdfs:subClassOf obo:IAO_0000013 .

obo:VO_0000056
    oboInOwl:hasURI "http://www.unitedvaccines.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "United Vaccines, Inc" .

obo:VO_0000057
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Heska Corporation" .

obo:VO_0000058
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Texas Vet lab, Inc" .

obo:VO_0000059
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "SolidTech Animal Health, Inc" .

obo:VO_0000060
    oboInOwl:hasURI "http://www.mvplabs.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "MVP Laboratories, Inc" .

obo:VO_0000061
    oboInOwl:hasURI "www.addisonlabs.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Addison Biological Laboratory, Inc" .

obo:VO_0000062
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Neotech, LLC" ;
    rdfs:seeAlso "neotechvaccines.com/" .

obo:VO_0000063
    obo:IAO_0000115 "The Imovax® 9 Rabies Vaccine is a sterile, stable, freeze-dried 10 suspension of rabies virus prepared from strain PM-1503-3M." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659730", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm180097.htm" ;
    obo:VO_0003099 "IMOVAX" ;
    obo:VO_0003158 "Rabies Vaccine" ;
    obo:VO_0003159 "Sanofi Pasteur, SA" ;
    obo:VO_0003160 "Vaccine for use in all age groups for pre-exposure and post-exposure prophylaxis against rabies." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf" ;
    obo:VO_0003162 103931 ;
    obo:VO_0003198 1659730 ;
    a owl:Class ;
    rdfs:label "Imovax Rabies (USA)" ;
    rdfs:seeAlso "CVX: 18" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003857
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000703 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000064
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/224903", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm101568.htm" ;
    obo:VO_0003099 "INFANRIX" ;
    obo:VO_0003158 "Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "For active immunization against diphtheria, tetanus, and pertussis as a 5-dose series in infants and children 6 weeks to 7 years of age." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf" ;
    obo:VO_0003162 "BL 103647" ;
    obo:VO_0003198 224903 ;
    a owl:Class ;
    rdfs:label "Infanrix" ;
    rdfs:seeAlso "CVX: 20" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003201
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000194
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000605
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000065
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://atomicnewsreview.org/2009/10/22/approval-for-the-arepanrix%E2%84%A2-gsk-vaccine-in-canada/" ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza Virus Vaccine, H5N1 (for National Stockpile)"^^xsd:string ;
    rdfs:label "Influenza Virus Vaccine H5N1 (Sanofi Pasteur Inc)" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_102793
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000066
    obo:IAO_0000115 "JE-VAX is a sterile, lyophilized vaccine for subcutaneous use, prepared by inoculating mice intracerebrally with Japanese encephalitis (JE) virus, “Nakayama-NIH” strain." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm179149.htm" ;
    obo:VO_0003099 "JE-Vax" ;
    obo:VO_0003158 "Japanese Encephalitis Virus Vaccine Inactivated" ;
    obo:VO_0003159 "Research Foundation for Microbial Diseases of Osaka University" ;
    obo:VO_0003160 "Indicated for Active Immunization against JE for persons one year age and older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf" ;
    a owl:Class ;
    rdfs:label "JE-Vax" ;
    rdfs:seeAlso "CVX: 39" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000698 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000067
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/801721", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm172495.htm"^^xsd:anyURI ;
    obo:VO_0003099 "KINRIX"^^xsd:anyURI ;
    obo:VO_0003158 "Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals"^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization against diphtheria, tetanus, pertussis, and poliomyelitis as the fifth dose in the diphtheria, tetanus, and acellular pertussis (DTaP) vaccine series and the fourth dose in the inactivated poliovirus vaccine (IPV) series in children 4 through 6 years of age whose previous DTaP vaccine doses have been with INFANRIX® and/or PEDIARIX® for the first three doses and INFANRIX® for the fourth dose."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125260"^^xsd:anyURI ;
    obo:VO_0003198 801721 ;
    a owl:Class ;
    rdfs:comment "Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine"^^xsd:string, "Trade Name: KINRIX" ;
    rdfs:label "Kinrix" ;
    rdfs:seeAlso "CVX: 130" ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003201
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003390
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003836
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003837
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000068
    obo:IAO_0000115 "a bacterial vaccine vector that uses L. moncytogenes as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Listeria monocytogenes vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 1639" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0000069
    obo:IAO_0000115 "A Measles-Mumps-Rubella vaccine that is live attenuated and manufactured by Merck & Co, Inc. " ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "MMR II" ;
    obo:IAO_0000119 "https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm094050.htm" ;
    obo:VO_0003099 "M-M-R II" ;
    obo:VO_0003158 "Measles, Mumps, and Rubella Virus Vaccine, Live" ;
    obo:VO_0003159 "Merck & Co., Inc" ;
    obo:VO_0003160 "M-M-R II is indicated for simultaneous vaccination against measles, mumps, and rubella in individuals 12 months of age or older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123789.pdf" ;
    obo:VO_0003162 "BL 101069" ;
    a owl:Class ;
    rdfs:label "M-M-R II" ;
    rdfs:seeAlso "CVX: 03" ;
    rdfs:subClassOf obo:VO_0000731, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015054
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015056
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000070
    obo:IAO_0000115 "A Measles-Mumps vaccine that is manufactured by Merck and used for human. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "MEASLES + MUMPS (MM-VAX)", "MM-VAX" ;
    obo:IAO_0000119 "http://novaccine.com/wp-content/uploads/2014/02/mmvax_package_insert.pdf" ;
    a owl:Class ;
    rdfs:comment "Product Name: Measles and Mumps Virus Vaccine, Live"^^xsd:string, "Trade Name: M-M-Vax" ;
    rdfs:label "M-M-Vax" ;
    rdfs:subClassOf obo:VO_0000736, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0000007
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0000074
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000071
    obo:IAO_0000115 "Menactra, Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, is indicated for active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y and W-135."^^xsd:anyURI ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine" ;
    obo:IAO_0000119 "WEB: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm176044.htm" ;
    obo:VO_0003099 "Menactra"^^xsd:anyURI ;
    obo:VO_0003158 "Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Sanofi Pasteur Inc"^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization of individuals 9 months through 55 years of age for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y and W-135."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "125089"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:comment "Product Name: Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine"^^xsd:string, "Trade Name: Menactra" ;
    rdfs:label "Menactra" ;
    rdfs:seeAlso "CVX: 114" ;
    rdfs:subClassOf obo:VO_0003441, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001256
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015063
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015069
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015070
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000072
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm179991.htm" ;
    obo:VO_0003099 "Menomune-A/C/Y/W-135" ;
    obo:VO_0003158 "Meningococcal Polysaccharide Vaccine, Groups A, C, Y, W-135 Combined" ;
    obo:VO_0003159 "Sanofi Pasteur Inc" ;
    obo:VO_0003160 "For active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135. Menomune – A/C/Y/W-135 vaccine is approved for use in persons 2 years of age and older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf" ;
    obo:VO_0003162 "BL 103926" ;
    a owl:Class ;
    rdfs:label "Menomune A C Y W135" ;
    rdfs:seeAlso "CVX: 32" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001256
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004859
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004860
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004888
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000073
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Rubella Virus Vaccine Live"^^xsd:string, "Trade Name: Meruvax II" ;
    rdfs:label "Meruvax II" ;
    rdfs:seeAlso "CVX: 06" ;
    rdfs:subClassOf obo:VO_0010637, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000074
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Mumps Virus Vaccine Live"^^xsd:string, "Trade Name: Mumpsvax" ;
    rdfs:label "Mumpsvax" ;
    rdfs:seeAlso "CVX: 07" ;
    rdfs:subClassOf obo:VO_0000656, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000075
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pBI/tTA DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000076
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pBISIA DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000077
    obo:IAO_0000115 "A Mycobacterium vaccine that protects against Mycobacterium tuberculosis." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "tuberculosis vaccine" ;
    a owl:Class ;
    rdfs:label "Mycobacterium tuberculosis vaccine" ;
    rdfs:seeAlso "MeSH: D032581" ;
    rdfs:subClassOf obo:VO_0000592 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1773
    ] .

obo:VO_0000078
    obo:IAO_0000116 """Mycobax is a BCG vaccine that is made by Sanofi Pasteur, Ltd.
Ref: http://www.biopharma.com/cgi/full6.lasso?Key=412.65916"""^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: BCG Vaccine"^^xsd:string, "Trade Name: Mycobax" ;
    rdfs:label "Mycobax" ;
    rdfs:seeAlso "CVX: 19" ;
    rdfs:subClassOf obo:VO_0000771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000079
    obo:IAO_0000115 "an influenza vaccine that is similar to Fluzone but has high dose. " ;
    obo:IAO_0000117 "Kallan Roan Oliver He" ;
    obo:IAO_0000119 "WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm112854.htm" ;
    obo:VO_0003158 "Fluzone High-Dose", "Influenza Virus Vaccine" ;
    obo:VO_0003159 "Sanofi Pasteur, Inc" ;
    obo:VO_0003160 "Fluzone High-Dose is indicated for active immunization of persons 65 years of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM619541.pdf" ;
    obo:VO_0003162 "BL 103914" ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza Virus Vaccine, Trivalent, Types A and B"^^xsd:string ;
    rdfs:label "Fluzone High-dose"@en ;
    rdfs:seeAlso "CVX: 140", "CVX: 141", "CVX: 144" ;
    rdfs:subClassOf obo:VO_0000047, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000080
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pBK-SFV DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000081
    obo:IAO_0000117 "Kallan Roan, Oliver He"^^xsd:anyURI ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm181973.htm"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza A (H1N1) 2009 Monovalent Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Novartis Vaccines and Diagnostics Limited"^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization of persons 4 years of age and older against influenza disease caused by pandemic (H1N1) 2009 virus."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM182242.pdf"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Influenza A (H1N1) 2009 Monovalent Vaccine (Novartis)" ;
    rdfs:subClassOf obo:VO_0003211, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000696 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000082
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/352877", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm146759.htm" ;
    obo:VO_0003099 "Pediarix" ;
    obo:VO_0003158 "Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine Combined" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "For active immunization against diphtheria, tetanus, pertussis, infection caused by all known subtypes of hepatitis B virus, and poliomyelitis. PEDIARIX is approved for use as a three-dose series in infants born of hepatitis B surface antigen (HBsAg)-negative mothers. PEDIARIX may be given as early as 6 weeks of age through 6 years of age (prior to the 7th birthday)." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf" ;
    obo:VO_0003162 "BL 103907" ;
    obo:VO_0003198 352877 ;
    a owl:Class ;
    rdfs:label "Pediarix" ;
    rdfs:seeAlso "CVX: 110" ;
    rdfs:subClassOf obo:VO_0000743, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003150
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003390
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003836
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003837
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000083
    obo:IAO_0000115 """PedvaxHIB is a highly purified capsular polysaccharide (polyribosylribitol phosphate or PRP) of Haemophilus
influenzae type b (Haemophilus b, Ross strain) that is covalently bound to an outer membrane protein complex (OMPC) of the B11 strain of Neisseria meningitidis serogroup B.""" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm253644.htm" ;
    obo:VO_0003099 "Liquid PedvaxHIB" ;
    obo:VO_0003158 "Haemophilus B Conjugate Vaccine (Meningococcal Protein Conjugate)" ;
    obo:VO_0003159 "Merck Sharp & Dohme Corp." ;
    obo:VO_0003160 "Liquid PedvaxHIB is indicated for routine vaccination against invasive disease caused by Haemophilus influenzae type b in infants and children 2 to 71 months of age." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf" ;
    obo:VO_0003162 "BL 103237/5285" ;
    a owl:Class ;
    rdfs:label "PedvaxHIB" ;
    rdfs:seeAlso "CVX: 49", "PMID:", "PMID: 2791073" ;
    rdfs:subClassOf obo:VO_0000662, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003408
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000084
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/674453", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm172502.htm" ;
    obo:VO_0003099 "Pentacel" ;
    obo:VO_0003158 "Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine" ;
    obo:VO_0003159 "Sanofi Pasteur Limited" ;
    obo:VO_0003160 "For active immunization against diphtheria, tetanus, pertussis, poliomyelitis and invasive disease caused by Haemophilus influenzae type b when administered to infants and children 6 weeks through 4 years of age (prior to fifth birthday)." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf" ;
    obo:VO_0003162 125145 ;
    obo:VO_0003198 674453 ;
    a owl:Class ;
    rdfs:label "Pentacel" ;
    rdfs:seeAlso "CVX: 120" ;
    rdfs:subClassOf obo:VO_0000744, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003390
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003836
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003837
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015014
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000085
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Plague Vaccine"^^xsd:string ;
    rdfs:label "Plague Vaccine by Greer Laboratories Inc" ;
    rdfs:seeAlso "CVX: 23" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000691 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000086
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pBudCE4.1 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000087
    obo:IAO_0000115 "a malaria vaccine that protects against malaria caused by Plasmodium falciparum." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Plasmodium falciparum vaccine" ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5833
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5833
    ] .

obo:VO_0000088
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000119 "https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm179996.htm" ;
    obo:VO_0003099 "Pneumovax 23" ;
    obo:VO_0003158 "Pneumococcal Vaccine, Polyvalent" ;
    obo:VO_0003159 "Merck & Co., Inc" ;
    obo:VO_0003160 "PNEUMOVAX 23 is indicated for active immunization against pneumococcal disease caused by those pneumococcal types included in the vaccine in persons 50 years of age or older and persons greater than or equal to 2 years of age who are at increased risk for pneumococcal disease." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf" ;
    obo:VO_0003162 "BLA 101094" ;
    a owl:Class ;
    rdfs:comment "Product Name: Pneumococcal Vaccine, Polyvalent"^^xsd:string ;
    rdfs:label "Pneumovax 23" ;
    rdfs:seeAlso "CVX: 33" ;
    rdfs:subClassOf obo:VO_0000424, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000888
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003212
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003217
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003218
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003219
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003220
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003221
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003222
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003223
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003224
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003225
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003226
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003227
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003232
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003246
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003248
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003249
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003250
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003252
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003253
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003254
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003255
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003561
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003959
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000089
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Poliovirus Vaccine Inactivated (Human Diploid Cell)"^^xsd:string, "Trade Name: Poliovax" ;
    rdfs:label "Poliovax" ;
    rdfs:subClassOf obo:VO_0000664, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000090
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm180017.htm", "https://www.prevnar13.com/" ;
    obo:VO_0003099 "Prevnar" ;
    obo:VO_0003158 "Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein)" ;
    obo:VO_0003159 "Wyeth Pharmaceuticals Inc" ;
    obo:VO_0003160 """- Immunization of infants 2, 4, 6 and 12-15 months of age to prevent invasive pneumococcal disease.
- Immunization of infants and toddlers against otitis media caused by vaccine serotypes.""" ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM137038.pdf" ;
    a owl:Class ;
    rdfs:comment "Product Name: Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein)"^^xsd:string, "STN: BLA 101094" ;
    rdfs:label "Prevnar" ;
    rdfs:seeAlso "CVX: 100", "VIOLIN Vaccine ID: 1114" ;
    rdfs:subClassOf obo:VO_0000424, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000091
    obo:IAO_0000115 "A Measles-Mumps-Rubella-Vericella vaccine that is live and manufactured by Merck & Co, Inc. " ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "WEB: http://www.merck.com/product/usa/pi_circulars/p/proquad/proquad_pi.pdf", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm188806.htm" ;
    obo:VO_0003099 "PROQUAD" ;
    obo:VO_0003158 "Measles, Mumps, Rubella and Varicella Virus Vaccine Live" ;
    obo:VO_0003159 "Merck & Co, Inc" ;
    obo:VO_0003160 "For vaccination against measles, mumps, rubella, and varicella in children 12 months to 12 years of age." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf" ;
    obo:VO_0003162 125108 ;
    a owl:Class ;
    rdfs:label "ProQuad" ;
    rdfs:seeAlso "CVX: 94" ;
    rdfs:subClassOf obo:VO_0000737, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003273
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015054
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015056
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000092
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 """WEB: 
https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm112854.htm""" ;
    obo:VO_0003099 "Fluzone Intradermal" ;
    obo:VO_0003158 "Influenza Virus Vaccine" ;
    obo:VO_0003159 "Sanofi Pasteur, Inc" ;
    obo:VO_0003160 "Fluzone Intradermal Quadrivalent indicated for active immunization for use in adults 18 through 64 years of age against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM566500.pdf" ;
    obo:VO_0003162 "BL 103914" ;
    a owl:Class ;
    rdfs:label "Fluzone Intradermal Quadrivalent"@en ;
    rdfs:subClassOf obo:VO_0003439, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003019
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000093
    obo:IAO_0000115 "a vaccine adjuvant that is formed as a mineral salt." ;
    obo:IAO_0000117 "SGS, YH" ;
    a owl:Class ;
    rdfs:label "mineral salt vaccine adjuvant" ;
    rdfs:seeAlso "CVX: 119" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0000094
    obo:IAO_0000115 "RabAvert Rabies Vaccine is a sterile, freeze-dried vaccine obtained by growing the fixed-virus strain Flury Low Egg Passage (LEP) in primary cultures of chicken fibroblasts." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf", "http://purl.bioontology.org/ontology/RXNORM/219579", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm133517.htm" ;
    obo:VO_0003099 "RabAvert" ;
    obo:VO_0003158 "Rabies Vaccine" ;
    obo:VO_0003159 "Novartis Vaccines and Diagnostics" ;
    obo:VO_0003160 "Pre-exposure and post-exposure immunization of children and adults" ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf" ;
    obo:VO_0003162 "BL 103334" ;
    obo:VO_0003198 219579 ;
    a owl:Class ;
    rdfs:label "RabAvert" ;
    rdfs:seeAlso "CVX: 18" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003862
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000486
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000696 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000095
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Rabies Vaccine Adsorbed"^^xsd:string ;
    rdfs:label "Rabies Vaccine Adsorbed by BioPort Corp" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000688 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000096
    obo:IAO_0000117 "Kallan Roan, Oliver He, SGS" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm247508.htm"^^xsd:anyURI ;
    obo:VO_0003158 "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral"^^xsd:anyURI ;
    obo:VO_0003159 "Barr Labs, Inc."^^xsd:anyURI ;
    obo:VO_0003160 "Indicated for active immunization for the prevention of febrile acute respiratory disease caused by Adenovirus Type 4 and Type 7."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125296/0"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral" ;
    rdfs:seeAlso "CVX: 143; UMLS_CUI: C0695130; SNOMEDCT: 442561000" ;
    rdfs:subClassOf obo:VO_0000037, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003164 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000097
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/496892", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094063.htm" ;
    obo:VO_0003099 "RotaTeq" ;
    obo:VO_0003158 "Rotavirus Vaccine, Live, Oral, Pentavalent" ;
    obo:VO_0003159 "Merck & Co, Inc" ;
    obo:VO_0003160 "For prevention of rotavirus gastroenteritis in infants 6 weeks to 32 weeks of age caused by types G1, G2, G3, G4, and G9." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf" ;
    obo:VO_0003162 "BL 125122" ;
    obo:VO_0003198 496892 ;
    a owl:Class ;
    rdfs:label "RotaTeq" ;
    rdfs:seeAlso "CVX: 116" ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004820
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004822
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004824
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004825
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000098
    obo:IAO_0000115 "a lentivirus vaccine vector that uses a SIV strain as the vector" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "SIV based lentivirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11723" ;
    rdfs:subClassOf obo:VO_0000359 .

obo:VO_0000099
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Pcaggs DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000100
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://academic.oup.com/cid/article/32/1/76/311106" ;
    a owl:Class ;
    rdfs:comment "T helper type 1 (Th1) lymphocytes secrete secrete interleukin (IL)-2, interferon-γ, and lymphotoxin-α and stimulate type 1 immunity, which is characterized by intense phagocytic activity. https://academic.oup.com/cid/article/32/1/76/311106" ;
    rdfs:label "vaccine-induced T-helper 1 type immune response" ;
    rdfs:subClassOf obo:VO_0000135 .

obo:VO_0000101
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://academic.oup.com/cid/article/32/1/76/311106" ;
    a owl:Class ;
    rdfs:comment "Th2 cells secrete IL-4, IL-5, IL-9, IL-10, and IL-13 and stimulate type 2 immunity, which is characterized by high antibody titers. https://academic.oup.com/cid/article/32/1/76/311106" ;
    rdfs:label "vaccine-induced T-helper 2 type immune response" ;
    rdfs:subClassOf obo:VO_0000135 .

obo:VO_0000102
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Tenivac" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm152800.htm"^^xsd:anyURI ;
    obo:VO_0003099 "TENIVAC"^^xsd:anyURI ;
    obo:VO_0003158 "Tetanus and Diphtheria Toxoids Adsorbed For Adult Use"^^xsd:anyURI ;
    obo:VO_0003159 "Sanofi Pasteur, Ltd, License #1726"^^xsd:anyURI ;
    obo:VO_0003160 "Indicated for active immunization for the prevention of tetanus and diphtheria in persons 7 years of age and older."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM152826.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "103171"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "TENIVAC" ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000103
    obo:IAO_0000115 "TICE BCG for intravesical use, is an attenuated, live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of Mycobacterium bovis." ;
    obo:IAO_0000116 "Intravesical TICE BCG has been used as a therapy for, and to prevent recurrence of, tumors in patients with carcinoma in situ (CIS) of the urinary bladder, and to prevent recurrence of Stage Ta T1 papillary tumors of the bladder at high risk of recurrence. Refernce URL: http://www.ticebcg.com/Consumer/aboutTice/index.asp"^^xsd:string ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm134033.htm" ;
    obo:VO_0003099 "TICE BCG" ;
    obo:VO_0003158 "BCG Live" ;
    obo:VO_0003159 "Organon Teknika Corp., LLC" ;
    obo:VO_0003160 "For the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder. For the prophylaxis of primary or recurrent state Ta and/or T1 papillary tumors following transurethral resection (TUR).", "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM163039.pdf" ;
    obo:VO_0003162 102821 ;
    a owl:Class ;
    rdfs:label "TICE BCG" ;
    rdfs:seeAlso "CVX: 19" ;
    rdfs:subClassOf obo:VO_0000177, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003054
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000697 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000104
    obo:IAO_0000115 "Typhim Vi, Typhoid Vi Polysaccharide Vaccine, for intramuscular use, is a sterile solution containing the cell surface Vi polysaccharide extracted from Salmonella enterica serovar Typhi, S typhi Ty2 strain." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/114883", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094072.htm" ;
    obo:VO_0003099 "Typhim Vi" ;
    obo:VO_0003158 "Typhoid Vi Polysaccharide Vaccine" ;
    obo:VO_0003159 "Sanofi Pasteur SA" ;
    obo:VO_0003160 "For active immunization against typhoid fever for persons two years of age or older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf" ;
    obo:VO_0003162 103936 ;
    obo:VO_0003198 114883 ;
    a owl:Class ;
    rdfs:label "TYPHIM VI" ;
    rdfs:seeAlso "CVX: 101" ;
    rdfs:subClassOf obo:VO_0003443, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003849
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000703 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000105
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "T cell epitope in vaccine" ;
    a owl:Class ;
    rdfs:label "vaccine T cell epitope" ;
    rdfs:subClassOf obo:VO_0000811 .

obo:VO_0000106
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced T cell mediated immunity" ;
    rdfs:subClassOf obo:VO_0000135 .

obo:VO_0000107
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T cell vaccine antigen processing and presentation" ;
    rdfs:subClassOf obo:VO_0000106 .

obo:VO_0000108
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus vaccine" ;
    rdfs:subClassOf obo:VO_0000025 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000025
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_235
            ]
        )
    ] .

obo:VO_0000109
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Tetanus Toxoid Adsorbed"^^xsd:string ;
    rdfs:label "Tetanus Toxoid Adsorbed by Aventis Pasteur Inc" ;
    rdfs:seeAlso "CVX: 35" ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000110
    obo:IAO_0000116 "E. coli Int280a has been found to be a protective antigen. This subunit vaccine uses E. coli Int280a combined with adjuvant. This antigen can be used for development of type-specific EPEC or EHEC vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli O157:H7 intimin vaccine" ;
    rdfs:seeAlso "PMID: 11500434" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000111
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use"^^xsd:string ;
    rdfs:label "Tetanus and Diphtheria Toxoids Adsorbed by MA Biologic Lab" ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000693 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000112
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed"^^xsd:string, "Trade Name: Tripedia" ;
    rdfs:label "Tripedia" ;
    rdfs:seeAlso "CVX: 20" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000194
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000113
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094035.htm" ;
    obo:VO_0003099 "Twinrix" ;
    obo:VO_0003158 "Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "Active immunization of persons 18 years of age or older against disease caused by hepatitis A virus and infection by all known subtypes of hepatitis B virus." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf" ;
    obo:VO_0003162 "BL 103850" ;
    a owl:Class ;
    rdfs:label "Twinrix" ;
    rdfs:seeAlso "CVX: 104" ;
    rdfs:subClassOf obo:VO_0000745, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000114
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCAGGST7 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000115
    a owl:Class ;
    rdfs:label "vaccine-induced T cell activation" ;
    rdfs:subClassOf obo:VO_0000008 .

obo:VO_0000116
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCBINT DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000117
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCdm7 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000118
    obo:IAO_0000117 "YH, SGS", "a vaccine adjuvant that contains microbial derived material." ;
    a owl:Class ;
    rdfs:label "microbial derivative vaccine adjuvant" ;
    rdfs:seeAlso "CVX: 52", "CVX: 83" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0000119
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094073.htm" ;
    obo:VO_0003158 "Varicella Virus Vaccine Live", "Varivax" ;
    obo:VO_0003159 "Merck & Co, Inc" ;
    obo:VO_0003160 "Indicated for active immunization for the prevention of varicella in individuals 12 months of age and older" ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142812.pdf", "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142813.pdf" ;
    obo:VO_0003162 "BL 103552" ;
    a owl:Class ;
    rdfs:label "Varivax" ;
    rdfs:seeAlso "CVX: 21" ;
    rdfs:subClassOf obo:VO_0000419, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000120
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094070.htm" ;
    obo:VO_0003099 "Vivotif" ;
    obo:VO_0003158 "Typhoid Vaccine Live Oral Ty21a" ;
    obo:VO_0003159 "Berna Biotech, Ltd." ;
    obo:VO_0003160 "For immunization of adults and children greater than 6 years of age against disease caused by Salmonella typhi." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf" ;
    obo:VO_0003162 103123 ;
    a owl:Class ;
    rdfs:label "Vivotif (USA)" ;
    rdfs:seeAlso "CVX: 25" ;
    rdfs:subClassOf obo:VO_0000671, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000687 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000121
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm180913.htm" ;
    obo:VO_0003099 "YF-Vax" ;
    obo:VO_0003158 "Yellow Fever Vaccine" ;
    obo:VO_0003159 "Sanofi Pasteur, Inc" ;
    obo:VO_0003160 """For active immunization of persons 9 months of age and older who:
- Are living in or traveling to endemic areas;
- Travelling internationally to countries that require evidence of vaccination from entering travelers or;
- Laboratory Personnel who might be expose to virulent yellow fever virus or to concentrated preparations of the yellow fever vaccine strain by direct or indirect contact or by aerosols should by vaccinated.""" ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf" ;
    obo:VO_0003162 "BL 103915" ;
    a owl:Class ;
    rdfs:label "YF-Vax" ;
    rdfs:seeAlso "CVX: 37" ;
    rdfs:subClassOf obo:VO_0003134, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003371
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000122
    obo:IAO_0000115 "a viral vaccine vector that uses Yellow fever vaccine strain 17D as the vector." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID: 16755933" ;
    a owl:Class ;
    rdfs:label "Yellow fever 17D vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11090" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0000123
    obo:IAO_0000115 "A viral vaccine that protects against infection with Yellow fever virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Yellow fever virus vaccine" ;
    rdfs:seeAlso "MeSH: D022341" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11089
    ] .

obo:VO_0000124
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm136941.htm" ;
    obo:VO_0003099 "Zostavax" ;
    obo:VO_0003158 "Zoster Vaccine, Live" ;
    obo:VO_0003159 "Merck & Co., Inc" ;
    obo:VO_0003160 "For prevention of herpes zoster (shingles) in individuals 50 years of age and older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM132831.pdf", "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM285015.pdf" ;
    obo:VO_0003162 125123 ;
    a owl:Class ;
    rdfs:label "Zostavax" ;
    rdfs:seeAlso "CVX: 121" ;
    rdfs:subClassOf obo:VO_0000419, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000125
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed turkey vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9005
    ] .

obo:VO_0000126
    obo:IAO_0000115 "a vaccine organism that is live and attenuated" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated vaccine organism" ;
    rdfs:subClassOf obo:VO_0000506, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ] .

obo:VO_0000127
    obo:IAO_0000115 "an aluminum vaccine adjuvant that contains aluminum hydroxide." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "alum" ;
    a owl:Class ;
    rdfs:label "aluminum hydroxide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000884 .

obo:VO_0000128
    obo:IAO_0000115 "an aluminum vaccine adjuvant that is aluminum phosphate." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "Adju-Phos®", "Al(PO)4" ;
    a owl:Class ;
    rdfs:label "aluminum phosphate vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000884 .

obo:VO_0000129
    obo:IAO_0000115 "Vaccination frequency is a qualitative term that represents how many times vaccination has occurred." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccination frequency" ;
    rdfs:subClassOf obo:PATO_0000044 .

obo:VO_0000130
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pcDNA I/Amp DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000131
    obo:IAO_0000115 "a mineral salt vaccine adjuvant composed of calcium phosphate." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "CaHPO4" ;
    a owl:Class ;
    rdfs:label "calcium phosphate vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000093 .

obo:VO_0000132
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pcDNA3 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000133
    obo:IAO_0000115 "an emulsion vaccine adjuvant that consists of a water-in-oil emulsion of aqueous antigen in paraffin (mineral) oil of low specific gravity and low viscosity. It is named after Jules T. Freund (1890-1960), Hungarian-born American immunologist. It is a water in oil emulsion." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "Freunds emulsified oil adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0000134
    a owl:Class ;
    rdfs:label "vaccine-induced T cell proliferation" ;
    rdfs:subClassOf obo:VO_0000115 .

obo:VO_0000135
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced adaptive immune response" ;
    rdfs:subClassOf obo:VO_0000287 .

obo:VO_0000136
    obo:IAO_0000115 "a viral vaccine vector that uses an adenovirus as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "adenovirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10508" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0000137
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a combination vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "combination vaccine role" ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000138
    obo:IAO_0000115 "YH", "a type of 'has vaccine vector' relation that specifies a bacterial vaccine vector" ;
    a owl:ObjectProperty ;
    rdfs:label "has bacterial vaccine vector"@en ;
    rdfs:range obo:NCBITaxon_2 ;
    rdfs:subPropertyOf obo:VO_0000530 .

obo:VO_0000139
    obo:IAO_0000115 "is a Freund's emulsfied oil adjuvant that contains inactivated and dried mycobacteria, usually Mycobacterium tuberculosis (the pathogenic agent of tuberculosis)." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "complete Freunds adjuvant" ;
    rdfs:subClassOf obo:VO_0000133 .

obo:VO_0000140
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "agglutinating antibody role" ;
    rdfs:subClassOf obo:VO_0000148 .

obo:VO_0000141
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "virulence factor - obsolete" ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0000142
    obo:IAO_0000115 "a Freud's adjuvant that does not contain the mycobacterial components." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "incomplete Freunds adjuvant" ;
    rdfs:subClassOf obo:VO_0000133 .

obo:VO_0000143
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant consisting of cholera toxin (CT) from Vibrio cholerae." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "CT", "cholera toxin" ;
    a owl:Class ;
    rdfs:label "cholera toxin vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0000144
    obo:IAO_0000115 "a viral vaccine vector that uses an alphavirus as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "alphavirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11019" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0000145
    obo:IAO_0000115 "a vaccine component role that inheres in a recombinant vaccine vector as a vaccine component. The combination of a recombinant vaccine vector and a heterogenous protective antigen(s) inserted inside the vector for a recombinant vector vaccine. " ;
    obo:IAO_0000117 "YH,YL" ;
    a owl:Class ;
    rdfs:label "recombinant vaccine vector role" ;
    rdfs:subClassOf obo:VO_0000617 .

obo:VO_0000146
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant that is the P40 particulate fraction isolated from Corynebacterium." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000119 "PMID: 8447157" ;
    a owl:Class ;
    rdfs:label "Corynebacterium-derived P40 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0000147
    obo:IAO_0000115 "an adjuvant role that inheres in a vaccine component which is added as part of a vaccine and induces enhanced adaptive immune response to the vaccine antigen. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment """The Latin \"adjuvans\" means to help, particularly to reach a goal.

Adjuvant therapy for cancer is surgery followed by chemotherapy or radiation to help decrease the risk of the cancer recurring (coming back).

An adjuvant is a substance that helps and enhances the pharmacological effect of a drug or increases the ability of an antigen to stimulate the immune system.""" ;
    rdfs:label "vaccine adjuvant role" ;
    rdfs:subClassOf obo:VO_0000415 .

obo:VO_0000148
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "antibody role" ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0000149
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Aceto Pharma Corp" .

obo:VO_0000150
    obo:IAO_0000115 "Antibody titer is a titer of antibody that shows how much antibody an organism has produced that recognizes a particular epitope, expressed as the greatest dilution ratio (or its reciprocal) that still gives a positive result. ELISA is a common means of determining antibody titers." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Antibody_titer" ;
    a owl:Class ;
    rdfs:label "antibody titer" ;
    rdfs:subClassOf obo:VO_0000555 .

obo:VO_0000151
    obo:IAO_0000115 "an organismal quality that indicates an organism (e.g., human) is immunized against a disease." ;
    obo:IAO_0000116 "To assign the state of ‘immunized’, we will need to do some assay to measure indicators of immunity, e.g., antibody titers in serum samples." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "immunized" ;
    rdfs:subClassOf obo:PATO_0001995 .

obo:VO_0000152
    obo:IAO_0000115 "a bacterial vaccine against an infection with F. tularensis." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Francisella tularensis vaccine" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000165
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_263
            ]
        )
    ] .

obo:VO_0000153
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a toxoid vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of toxoid vaccine"@en ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000561
    ] .

obo:VO_0000154
    obo:IAO_0000115 "A Brucella abortus gene that has the name sodC and comes from strain 2308. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment """IMMUNOGENICITY: The SodC protein induces antigen-specific Th1 immune response, as indicated by the specific induction of serum IgG2a, but not IgG1, antibodies and by the secretion of IFN-alpha but not IL-4, by the Cu/Zn SOD-stimulated splenocytes. This gene has been used for vaccine development [PubMed: 10816475][PubMed: 11953393][PubMed: 12933826].    

MUTATION: An isogenic sodC mutant constructed from B abortus 2308 by gene replacement exhibited much greater susceptibility to killing by exogenous O(2)(-) than the parental 2308 strain, supporting a role for SodC in protecting this bacterium from O(2)(-) stress. The B abortus sodC mutant was much more sensitive to killing by cultured resident peritoneal macrophages from C57BL6J mice than 2308, and its attenuation in cultured murine macrophages was enhanced when these phagocytes were treated with gamma interferon. The attenuation of the B abortus sodC mutant in both resting and IFN-gamma-activated macrophages was alleviated in the presence of the NADPH oxidase inhibitor apocynin. Consistently, the B abortus sodC mutant also displayed significant attenuation in infected C57BL6J mice compared to the parental strain. These findings suggest that SodC protects B abortus 2308 from the respiratory burst of host macrophages [PubMed: 15845493].""" ;
    rdfs:label "sodC from B. abortus strain 2308" ;
    rdfs:seeAlso "NCBI Gene GI: 3827840; NCBITaxon: 234" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_359391
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0000155
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bacterial gene - Obsolete" ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0000156
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "viral gene" ;
    rdfs:subClassOf obo:OGG_0000000002 .

obo:VO_0000157
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "HIV gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000158
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pcDNA3.1 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000159
    obo:IAO_0000112 "Brucella abortus cattle vaccine RB51 was developed by serial passages of virulent B. abortus strain 2308 in vitro in rifampin agar plates (Reference: PMID: 1908158)." ;
    obo:IAO_0000115 "A live attenuated vaccine prepraration process that is performed by serial passages in vitro for pathogen attenuation." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of live attenuated vaccine by serial passages in vitro"@en ;
    rdfs:subClassOf obo:VO_0000718 .

obo:VO_0000160
    obo:IAO_0000117 "Kallan Roan, Oliver He"^^xsd:anyURI ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm181971.htm"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza A (H1N1) 2009 Monovalent Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Sanofi Pasteur, Inc."^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization of persons 6 months of age and older against influenza disease caused by pandemic (H1N1) 2009 virus."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM182404.pdf"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Influenza A (H1N1) 2009 Monovalent Vaccine (Sanofi Pasteur)" ;
    rdfs:subClassOf obo:VO_0003211, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000161
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "E. coli gene" ;
    a owl:Class ;
    rdfs:label "Escherichia coli gene" ;
    rdfs:subClassOf obo:OGG_2000000002 .

obo:VO_0000162
    obo:IAO_0000115 "a virulence of vaccine organism that shows an avirulent pheontype of the organism as the major component of a vaccine. The avirulence means that an vaccine organism is not virulent and does not cause pathogenic phenotype in a host organism." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine organism avirulent" ;
    rdfs:subClassOf obo:PATO_0002146 .

obo:VO_0000163
    a owl:Class ;
    rdfs:label "vaccine-induced gene up-regulation controlling intracellular bacterial replication"@en ;
    rdfs:subClassOf obo:VO_0000569 .

obo:VO_0000164
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Mycobacterium tuberculosis gene" ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_1773
    ] .

obo:VO_0000165
    obo:IAO_0000115 "A vaccine that targets against a bacterial disease." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bacterial vaccine" ;
    rdfs:seeAlso "MeSH: D001428" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2
    ] .

obo:VO_0000166
    obo:IAO_0000115 "a vaccine vector that uses a live bacterium as the vector " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bacterial vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 2" ;
    rdfs:subClassOf obo:VO_0000599 .

obo:VO_0000167
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pcDNA3.1V5HisTOPO/TA DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000168
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Salmonella gene" ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0000169
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Shigella gene" ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_620
    ] .

obo:VO_0000170
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "protozoan gene" ;
    rdfs:subClassOf obo:OGG_0000000002 .

obo:VO_0000171
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Plasmodium gene" ;
    rdfs:subClassOf obo:VO_0000170 .

obo:VO_0000172
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Plasmodium falciparum gene" ;
    rdfs:subClassOf obo:VO_0000171 .

obo:VO_0000173
    obo:IAO_0000115 "a virulence of vaccine organism that shows an attenuated pheontype of the organism as the major component of a vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine organism live attenuated" ;
    rdfs:subClassOf obo:PATO_0002146 .

obo:VO_0000174
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Leishmania gene" ;
    rdfs:subClassOf obo:VO_0000170 .

obo:VO_0000175
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCEP4 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000176
    a owl:Class ;
    rdfs:label "vaccine-induced T cell differentiation" ;
    rdfs:subClassOf obo:VO_0000115 .

obo:VO_0000177
    obo:IAO_0000115 "A vaccine that prevents or treats cancer. It is produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "neoplasm vaccine", "tumor vaccine" ;
    a owl:Class ;
    rdfs:label "cancer vaccine" ;
    rdfs:seeAlso "MeSH: D019496" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001011 ;
        owl:someValuesFrom obo:DOID_162
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001011 ;
        owl:someValuesFrom obo:DOID_162
    ] .

obo:VO_0000178
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a inactivated vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "inactivated vaccine preparation" ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001103
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000315
    ] .

obo:VO_0000179
    obo:IAO_0000115 "a processed material that is output of the vaccine preparation and part of a vaccine." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "cardinal part of vaccine", "vaccine ingredient" ;
    a owl:Class ;
    rdfs:label "vaccine component" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:BFO_0000040
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000050 ;
                owl:someValuesFrom obo:VO_0000001
            ]
        )
    ] .

obo:VO_0000180
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced cell activation" ;
    rdfs:subClassOf obo:VO_0000287 .

obo:VO_0000181
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant made from bacterial lipopolysaccharide (LPS) of gram-negative bacteria." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "LPS vaccine adjuvant" ;
    a owl:Class ;
    rdfs:label "lipopolysaccharide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0000182
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced antibacterial agglutination antibody response" ;
    rdfs:subClassOf obo:VO_0000309 .

obo:VO_0000183
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000184
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000185
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000186
    obo:IAO_0000115 "A vaccine that uses RNA(s) derived from a pathogen organism." ;
    obo:IAO_0000116 "Using RNA may eliminate the problem of having to tailor a vaccine for each individual patient with their specific immunity. The advantage of RNA is that it can be used for all immunity types and can be taken from a single cell. DNA vaccines need to produce RNA which then prompts the manufacture of proteins. However, RNA vaccine eliminates the step from DNA to RNA." ;
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000118 "mRNA vaccine" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/RNA_vaccine" ;
    a owl:Class ;
    rdfs:label "RNA vaccine" ;
    rdfs:subClassOf obo:VO_0000001 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000728
    ] .

obo:VO_0000187
    obo:IAO_0000115 "a synthetic vaccine adjuvant formulated to correspond to a component found in a water-soluble extract of cell walls of mycobacteria used in complete Freund's adjuvant (CFA)." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "MDP", "muramyl dipeptide" ;
    obo:IAO_0000119 "PMID: 344799" ;
    a owl:Class ;
    rdfs:label "muramyl dipeptide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0000188
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000189
    obo:IAO_0000116 "Colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. Unlike in direct microscopic counts where all cells, dead and living, are counted, CFU measures viable cells. By convenience the results are given as CFU/mL (colony-forming units per milliliter) for water, and CFU/g (colony-forming units per gram) for soil or other porous material." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "CFU"^^xsd:string ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Colony-forming_unit" ;
    a owl:Class ;
    rdfs:label "colony forming unit" ;
    rdfs:subClassOf obo:VO_0000555 .

obo:VO_0000190
    obo:IAO_0000115 "an emulsion vaccine adjuvant that contains an organic polymer with some antigenic epitopes which might be shared with other organic polymers acting as immunostimulators." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "squalene" ;
    a owl:Class ;
    rdfs:label "squalene vacccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0000191
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is an emulsifier called Arlacel A." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "arlacel A" ;
    obo:IAO_0000119 "PMID: 2042393" ;
    a owl:Class ;
    rdfs:label "arlacel A vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0000192
    obo:IAO_0000117 "YH", "a montanide vaccine adjuvant that is Montanide 103." ;
    obo:IAO_0000118 "Montanide 103" ;
    a owl:Class ;
    rdfs:label "Montanide 103 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001271 .

obo:VO_0000193
    obo:IAO_0000115 "a microbial derivitive vaccine adjuvant that contains components from killed Bordetella pertussis. The killed B. pertussis has a strong adjuvant effect on the diphtheria and tetanus toxoids in the DPT vaccines." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis component vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0000194
    obo:IAO_0000115 "a USA licensed vaccine role that inheres ina vaccine approven to be by the US FDA to be used for humans in the USA. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "USA licensed human vaccine role"@en ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000489
            obo:VO_0000812
        )
    ] .

obo:VO_0000195
    obo:IAO_0000115 "Conjugate vaccine is vaccine that conjugates/links antigens to the molecules that form the outer coat of disease-causing bacteria to promote an immune response." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "A conjugate vaccine is created by covalently attaching a poor (polysaccharide organism) antigen to a carrier protein (preferably from the same microorganism), thereby conferring the immunological attributes of the carrier on the attached antigen. --from wikipedia." ;
    rdfs:label "conjugate vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ] .

obo:VO_0000196
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a recombinant vector vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of recombinant vector vaccine"@en ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000484
    ] .

obo:VO_0000197
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "West Nile virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000198
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "chickenpox virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000199
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Rubella virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000200
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657331" ;
    obo:VO_0003198 1657331 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0015084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003584
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003616
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003627
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003715
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003721
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003744
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003757
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003763
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003890
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003910
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0015080
    ] .

obo:VO_0000201
    obo:IAO_0000116 "Characteristics: Inactivated baculovirus expressed PCV2 ORF2 protein; adjuvanted" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Porcilis-PCV2" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000202
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis A virus gene" ;
    rdfs:subClassOf obo:VO_0000156 .

obo:VO_0000203
    obo:IAO_0000116 "Characteristics: Inactivated PCD1-2 chimera; adjuvanted" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Suvaxyn PCV2" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000205 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000204
    obo:IAO_0000116 "Intervet has merged with Schering-Plough Animal Health  and become Intervet/Schering-Plough Animal Health™ (YL.)"@en ;
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.intervet.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Intervet" .

obo:VO_0000205
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.wyeth.com/divisions/fort_dodge.asp" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Fort Dodge" .

obo:VO_0000206
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed pig vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ] .

obo:VO_0000207
    obo:IAO_0000115 "A vaccine contraindication is a contraindication that increases the risks of a vaccination. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "contraindication for vaccination" ;
    a owl:Class ;
    rdfs:label "vaccine contraindication" ;
    rdfs:subClassOf obo:OAE_0000055 .

obo:VO_0000208
    obo:IAO_0000115 "a vaccine role that is not licensed or in clinical trial; instead, it has been experimently approved to induce protection or treatment effect in vivo in at least an experimental animal model. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine in research role" ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000209
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pHIS64 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000210
    obo:IAO_0000115 "an immune response detection assay that detects specific antiviral antibodies in a test serum. The serum, usually a twofold dilution series, is mixed with a standard number, usually 4 to 8 HA units, of virus and incubated prior to the addition of a standard suspension of erythrocytes. The highest dilution of serum that inhibits hemagglutination is the HI titer of the serum. For example, influenza (AI) viruses agglutinate erythrocytes through the interaction of the virus surface glycoprotein, the hemagglutinin (HA), with receptors on the surface of the erythrocyte. Inhibition of the agglutination reaction by HA subtype-specific antisera is the basis of the hemagglutination-inhibition (HI) assay." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "HI assay" ;
    a owl:Class ;
    rdfs:label "hemagglutination-inhibition assay" ;
    rdfs:subClassOf obo:VO_0000584 .

obo:VO_0000211
    obo:IAO_0000115 "an organismal quality of a whole organism vaccine where the whole organism is inactivated/killed and lacks the capability of replication. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "vaccine organism killed" ;
    a owl:Class ;
    rdfs:label "vaccine organism inactivated" ;
    rdfs:subClassOf obo:VO_0001139 .

obo:VO_0000212
    obo:IAO_0000115 "a DNA vaccine plasmid that uses the plasmid labeled pCI." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/nuccore/5870896" ;
    a owl:Class ;
    rdfs:label "pCI DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001010 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000213
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitivity to chicken product" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000214
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCI-neo DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000215
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000216
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV-1 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000217
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV4 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000218
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitivity to chicken egg" ;
    rdfs:subClassOf obo:VO_0000213 .

obo:VO_0000219
    obo:IAO_0000115 "a vaccine component that is used to dissolve vaccine powder into liquid. The vaccine in a powder form has to be reconstituted by mixing vaccine powder with vaccine solvent before administered." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "vaccine diluent", "vaccine liquid diluent" ;
    a owl:Class ;
    rdfs:label "vaccine solvent" ;
    rdfs:subClassOf obo:VO_0000179 .

obo:VO_0000220
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMVI.UBF3/2 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000221
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV-3FUB DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000222
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV-int DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000223
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV-LacZ DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000224
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitivity to antibiotic" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000225
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitivity to neomycin" ;
    rdfs:subClassOf obo:VO_0000224 .

obo:VO_0000226
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitivity to polymyxin" ;
    rdfs:subClassOf obo:VO_0000224 .

obo:VO_0000227
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "reaction to previous vaccination" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000228
    obo:IAO_0000115 "a vaccine component that contains the solid form of all vaccine components. A vaccine can be reconstituted by mixing vaccine powder with vaccine solvent." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine powder"@en ;
    rdfs:subClassOf obo:VO_0000179 .

obo:VO_0000229
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a bacterial vaccine"@en ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "bacterial vaccine preparation" ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000165
    ] .

obo:VO_0000230
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMV-LIC DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000231
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCMVLuc DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000232
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCR3 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000233
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "life-threatening reaction to previous vaccination" ;
    rdfs:subClassOf obo:VO_0000227 .

obo:VO_0000234
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCR3.1 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000235
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "life-threatening reaction to previous influenza vaccination" ;
    rdfs:subClassOf obo:VO_0000233 .

obo:VO_0000236
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pCR4-TOPO DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000237
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitivity to gentamicin" ;
    rdfs:subClassOf obo:VO_0000224 .

obo:VO_0000238
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "dominant epitope in vaccine" ;
    a owl:Class ;
    rdfs:label "vaccine dominant epitope" ;
    rdfs:subClassOf obo:VO_0000811 .

obo:VO_0000239
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced down-regulated gene expression" ;
    rdfs:subClassOf obo:VO_0000286 .

obo:VO_0000240
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitity to gelatin" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000241
    obo:IAO_0000115 "A vaccine prepraration process that is performed by heat inactivation of virulent pathogen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of vaccine using heat inactivation"@en ;
    rdfs:subClassOf obo:VO_0000178 .

obo:VO_0000242
    obo:IAO_0000115 "CFU reduction assay is an assay that measures the reduction of the colony forming units of infected pathogens in vaccine-vaccinated animals compared to nonvaccinated animals." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "CFU reduction assay" ;
    rdfs:subClassOf obo:OBI_0000070 .

obo:VO_0000243
    obo:IAO_0000115 "assay of CFU reduction in spleen is a CFU reduction assay that is measured using the extracted spleen as the tissue for isolation of infected pathogens." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "assay of CFU reduction in spleen" ;
    rdfs:subClassOf obo:VO_0000242 .

obo:VO_0000244
    obo:IAO_0000116 "Arginine is a conditionally essential amino acid, meaning most of the time it can be manufactured by the human body, and does not need to be obtained directly through the diet. The biosynthetic pathway however does not produce sufficient arginine, and some must still be consumed through diet. Individuals who have poor nutrition or certain physical conditions may be advised to increase their intake of foods containing arginine. Infants are unable to meet their requirements and thus arginine is nutritionally essential for infants." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "hypersensitity to arginine" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000245
    obo:IAO_0000115 """A physical quality inhering in a bearer by virtue of the bearer being fit
to be eaten.""" ;
    obo:IAO_0000116 """Melanie has submitted this term and its two subclasses to obo:
http://sourceforge.net/tracker/?func=detail&aid=2873643&group_id=76834&atid=595654""" ;
    obo:IAO_0000117 "YH, MC" ;
    a owl:Class ;
    rdfs:label "edibility" ;
    rdfs:subClassOf obo:PATO_0001237 .

obo:VO_0000246
    obo:IAO_0000115 "A quality of edibility that inheres in a bearer by virtue of the bearer being suitable for oral ingestion as food, drug, or vaccine." ;
    obo:IAO_0000117 "This term may be submitted to PATO.", "YH" ;
    a owl:Class ;
    rdfs:label "edible" ;
    rdfs:subClassOf obo:VO_0000245 .

obo:VO_0000247
    obo:IAO_0000115 """Vaccine efficacy is an efficacy of a vaccine in induction of protective immune response in vivo or protection against infection of a virulent pathogen. 
Specifically, vaccine efficacy (VE) is the percentage reduction in disease incidence attributable to vaccination, calculated by means of the following equation:
VE(%) = (U - V)/U x 100
where U = the incidence in unvaccinated people and 
V = the incidence in vaccinated people.
Ref: Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71.""" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine efficacy" ;
    rdfs:subClassOf obo:PATO_0001029 .

obo:VO_0000248
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "history of asthma" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000249
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced antiviral neutralizing antibody response" ;
    rdfs:subClassOf obo:VO_0000309 .

obo:VO_0000250
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pcREV DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000251
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pgp.LAMP-1.  This plasmid has a CMV promoter and contains the human lysosomal-associated membrane protein-1 signal sequence." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pgp.LAMP-1 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 19356616" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000252
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pDRVISV1.0 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000253
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pECK DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000254
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pES.  This plasmid has a CMV promoter and contains a kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pES DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 19406186" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000255
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "usage of bronchodilator" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000256
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pET21a DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000257
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pET-28a DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000258
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pGA DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000259
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pGEX-3X DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000260
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced follicular dendritic cell activation" ;
    rdfs:subClassOf obo:VO_0000180 .

obo:VO_0000261
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "usage of steroid" ;
    rdfs:subClassOf obo:VO_0000207 .

obo:VO_0000262
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pIRES DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000263
    obo:IAO_0000115 "sodBFt is a live vaccine strain mutant of Francisella tularensis with reduced Fe-superoxide dismutase gene expression. Ref: PMID: 18692537." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice were vaccinated intranasally (i.n.) with the sodB(Ft) mutant and challenged i.n. with lethal doses of F. tularensis SchuS4. SodB(Ft) vaccinated mice following SchuS4 challenge exhibited significantly reduced bacterial burden in lungs, liver and spleen, regulated production of pro-inflammatory cytokines and less severe histopathological lesions compared to the LVS vaccinated mice. The sodB(Ft) vaccination induced a potent humoral immune response and protection against SchuS4 required both CD4 and CD8 T cells in the vaccinated mice" ;
    rdfs:label "sodB(Ft)" ;
    rdfs:seeAlso "PMID: 16923916", "PMID: 18692537" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000264
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "ProtaTek International, Inc" ;
    rdfs:seeAlso "www.protatek.com/" .

obo:VO_0000265
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Arko Laboratories Ltd" ;
    rdfs:seeAlso "www.arkolabs.com/" .

obo:VO_0000266
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "fungal disease" ;
    rdfs:subClassOf obo:DOID_4 .

obo:VO_0000267
    obo:IAO_0000115 "A vaccine that targets against a fungus infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "fungal vaccine" ;
    rdfs:seeAlso "MeSH: D005657" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_4751
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_4751
    ] .

obo:VO_0000268
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Newport Laboratories, Inc" ;
    rdfs:seeAlso "www.newportlabs.com" .

obo:VO_0000269
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Texas Agricultural Experiment Station" .

obo:VO_0000270
    obo:IAO_0000115 "has_vaccine_contraindication is a relation that specifies contraindication of a vaccine." ;
    obo:IAO_0000116 "This relation may be replaced by has_vaccine_allergen. We need to determine if any vaccine contraindicator is not a vaccine allergen." ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has vaccine contraindication" .

obo:VO_0000271
    obo:IAO_0000115 "A live attenuated Francisella tularensis vaccine. It is available in American Type Culture Collection with ATCC ID: 29684." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "F. tularensis vaccine LVS" ;
    rdfs:seeAlso "PMID: 16912944", "PMID: 8757866" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001014
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000272
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pIRES2 DsRed2 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000273
    a owl:Class ;
    rdfs:label "vaccine-induced T cell interferon-gamma production"@en ;
    rdfs:subClassOf obo:VO_0000593 .

obo:VO_0000274
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pING DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000275
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pJW24 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000276
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pJW4303 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000277
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pK0 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000278
    obo:IAO_0000115 "vaccine function is a function that inheres in a vaccine that induces protective immune response against a disease. It is realized in the immunization process in the host."@en ;
    obo:IAO_0000116 "PERSPN: Oliver He: There has been hot discussion about whether we use 'vaccine function' or 'vaccine role'. Vaccine role may not be the good term to use. Vaccine is designed to be 'vaccine', so it should be vaccine function. One special case is cowpox virus. The cowpox virus can be mixed with some liquid like water and used as a smallpox vaccine. In this case, people often say: the cowpox virus has a 'vaccine role'. However, the cowpox virus vaccine is a processed material of a mix of the virus with water. The virus is a virus, it is not a vaccine per se. Therefore, vaccine role may not be an accurate term." ;
    obo:IAO_0000117 "YH, MC, XZ, and AR" ;
    a owl:Class ;
    rdfs:label "vaccine function" ;
    rdfs:subClassOf obo:BFO_0000034 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:unionOf (obo:VO_0000452
            obo:VO_0000562
        )
    ] .

obo:VO_0000279
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pK3 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000280
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pMV60 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000281
    obo:IAO_0000115 "a type of 'has vaccine vector' that is specifically for viral vaccine vector" ;
    a owl:ObjectProperty ;
    rdfs:label "has viral vaccine vector"@en ;
    rdfs:subPropertyOf obo:VO_0000530 .

obo:VO_0000282
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pMAMneoBlue DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000283
    obo:IAO_0000115 "a viral vaccine vector that uses a herpesvirus as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "herpesvirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10292" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0000284
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pMASIA DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000285
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pND DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000286
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced host gene response" ;
    rdfs:subClassOf obo:VO_0000288 .

obo:VO_0000287
    obo:IAO_0000115 "Any immune system process that functions in the calibrated response of the host to a vaccine." ;
    obo:IAO_0000116 "The definition of this term is based on the definition of 'immune response (GO:0006955)' . It is a child term of this GO term." ;
    obo:IAO_0000117 "Y.L." ;
    dc:creator "Y.H." ;
    a owl:Class ;
    rdfs:label "vaccine-induced host immune response" ;
    rdfs:subClassOf obo:VO_0000288 .

obo:VO_0000288
    obo:IAO_0000115 "a processual entity that specifies host response to a vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced host response" ;
    rdfs:subClassOf obo:BFO_0000015, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:VO_0000001
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:OBI_0100026
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:OBI_0000725
                ]
            )
        ]
    ] .

obo:VO_0000289
    obo:IAO_0000115 "a process that specifies host response to a vaccine adjuvant." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "host response to vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000290 .

obo:VO_0000290
    obo:IAO_0000115 "a processual entity that specifies host response to a vaccine component." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "host response to vaccine component" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0000291
    obo:IAO_0000115 "a process that specifies host response to a vaccine antigen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "host response to vaccine antigen" ;
    rdfs:subClassOf obo:VO_0000290 .

obo:VO_0000292
    obo:IAO_0000115 "a process that specifies host response to a vaccine vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "host response to vaccine vaccine vector" ;
    rdfs:subClassOf obo:VO_0000290 .

obo:VO_0000293
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pND2 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000294
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pNGVL DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000295
    obo:IAO_0000115 "A viral vaccine that protects against infection with human immunodeficiency virus that causes AIDS." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "AIDS vaccine", "HIV vaccine" ;
    a owl:Class ;
    rdfs:label "human immunodeficiency virus vaccine" ;
    rdfs:seeAlso "MeSH: D016915" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_12721
            ]
        )
    ] .

obo:VO_0000296
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Brinton Laboratories Inc" .

obo:VO_0000297
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pNL3-gal DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000298
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pN4a-gal DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000299
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Company" ;
    dc:description "A legal organization that represents an association of people with a specific objective." ;
    a owl:Class ;
    rdfs:label "company" ;
    rdfs:subClassOf obo:OBI_0000245 .

obo:VO_0000300
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis strain VTRM1" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000301
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pRc/CMV DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000302
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pRc/CMV2 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000303
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. suis VTRS1" ;
    a owl:Class ;
    rdfs:label "Brucella suis strain VTRS1" ;
    rdfs:seeAlso "PMID: 17428946" ;
    rdfs:subClassOf obo:VO_0001136, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000304
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pRK DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000305
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pRSV DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000306
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pRSV0 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000307
    obo:IAO_0000115 "KKF24 is a recombinant strain of Francisella novicida U112 with iglC mutation (F. novicida delta-iglC::ermC). PMID: 14680699." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "KKF24" ;
    rdfs:seeAlso "PMID: 16552035" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000308
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "F. tularensis vaccine LVS lipopolysaccharide" ;
    a owl:Class ;
    rdfs:label "F. tularensis vaccine LVS LPS" ;
    rdfs:seeAlso "PMID: 10722593" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000208
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000309
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "immunoglobulin mediated immune response to vaccine" ;
    a owl:Class ;
    rdfs:label "vaccine-induced antibody mediated immune response" ;
    rdfs:subClassOf obo:VO_0000012 .

obo:VO_0000310
    obo:IAO_0000115 "a vaccine additive that stabilizes the vaccine emulsification manufacturing process and makes emulsion of the vaccine easier. " ;
    obo:IAO_0000117 "YH, YL" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/16337664 " ;
    a owl:Class ;
    rdfs:comment "Emulsifiers help bind ingredients together and keep them from separating, most commonly with oil and water. An emulsifier is also a surfactant that reduces the surface tension of a liquid and results in an easier, smoother spread. Reference: http://www.wisegeek.org/what-is-polysorbate-80.htm " ;
    rdfs:label "vaccine emulsifier"@en ;
    rdfs:subClassOf obo:VO_0000179 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0003025
            ]
        )
    ] .

obo:VO_0000311
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis lipopolysaccharide vaccine" ;
    rdfs:subClassOf obo:VO_0001223, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000525 ;
        owl:someValuesFrom obo:CHEBI_16412
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000312
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. melitensis LPS-GBOMP subunit vaccine" ;
    a owl:Class ;
    rdfs:label "B. melitensis LPS-GBOMP noncovalent complex vaccine" ;
    rdfs:seeAlso "PMID: 8723881" ;
    rdfs:subClassOf obo:VO_0001223, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000313
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pSC65 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000314
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pSG2 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000315
    obo:IAO_0000115 "A whole organism vaccine that uses an inativated pathogen organism as its component." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "inactivated organism vaccine", "killed vaccine"^^xsd:string ;
    a owl:Class ;
    rdfs:label "inactivated vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0000316
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pSG5 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000317
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Psin DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000318
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pTARGET DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000319
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pTH DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000320
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pTHamp DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000321
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus DNA vaccine expressing BCSP31, SOD and L7/L12" ;
    a owl:Class ;
    rdfs:label "Brucella abortus DNA vaccine encoding BCSP31, SOD and L7/L12" ;
    rdfs:seeAlso "PMID: 17570767" ;
    rdfs:subClassOf obo:VO_0001225, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0000154
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000322
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pTR600 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000323
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "recombinant B. abortus L7/L12 vaccine" ;
    obo:IAO_0000119 "PMID: 8873388" ;
    a owl:Class ;
    rdfs:label "Brucella abortus conjugate vaccine using L7/L12" ;
    rdfs:subClassOf obo:VO_0000956, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010928
    ] .

obo:VO_0000324
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pTVG4 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000325
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis DNA vaccine encoding Omp31" ;
    rdfs:seeAlso "PMID: 17428946" ;
    rdfs:subClassOf obo:VO_0001226, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010939
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000326
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pUC18 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000327
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pUC19 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000328
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pV1J DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000329
    obo:IAO_0000115 "bacterial vaccine that protect against Mycoplasma hyopneumoniae infection" ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "Mycoplasma hyopneumoniae vaccine" ;
    rdfs:subClassOf obo:VO_0000604, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2099
    ] .

obo:VO_0000330
    obo:IAO_0000115 "A quality of edibility that inheres in a bearer by virtue of the bearer being not suitable for oral ingestion." ;
    obo:IAO_0000117 "YH, MC" ;
    a owl:Class ;
    rdfs:label "inedible" ;
    rdfs:subClassOf obo:VO_0000245 .

obo:VO_0000331
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pVCL(pCXN2-mVIN) DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000332
    obo:IAO_0000115 "tertiary vaccination is a vaccination that is performed at the third time in a row." ;
    obo:IAO_0000117 "YH, Thom Todd" ;
    a owl:Class ;
    rdfs:label "tertiary vaccination" ;
    rdfs:subClassOf obo:VO_0000708, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000062 ;
        owl:someValuesFrom obo:VO_0000903
    ] .

obo:VO_0000333
    obo:IAO_0000115 "Protozoa are a diverse group of unicellular eukaryotic organisms,[1] many of which are motile. Originally, protozoa had been defined as unicellular protists with animal-like behavior, e.g., movement. Protozoa were regarded as the partner group of protists to protophyta, which have plant-like behaviour, e.g., photosynthesis.(http://en.wikipedia.org/wiki/Protozoa)" ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "Protozoa" ;
    rdfs:subClassOf obo:NCBITaxon_2759 .

obo:VO_0000334
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pVR1012 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000335
    obo:IAO_0000115 "a vaccination site that is used for injection of a vaccine. " ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "vaccine injection site" ;
    rdfs:subClassOf obo:VO_0003247 .

obo:VO_0000336
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pVR1012x/s DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000337
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pWRG1644 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000338
    obo:IAO_0000115 "A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the bp26 deletion. It has similar vaccine efficacy to Rev. 1. Its advantage compared to Rev. 1 is that this feature of bp26 deletion promotes diagnosis. PMID: 17070627." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Brucella CGV26", "CGV26" ;
    a owl:Class ;
    rdfs:label "B. melitensis bp26 deletion vaccine" ;
    rdfs:seeAlso "PMID: 16519974" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_29459
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:VO_0002561
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ] .

obo:VO_0000339
    obo:IAO_0000115 "A spontaneous mutant of the SCHU S4 strain that protects against virulent F. tularensis infection. PMID: 16299332." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "F. tularensis vaccine FSC043" ;
    rdfs:seeAlso "PMID: 16299332" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000340
    obo:IAO_0000115 "a route of administration that inject the material(such as vaccines, allergens) directly into a muscle." ;
    obo:IAO_0000117 "YH,YL" ;
    obo:IAO_0000118 "intramuscular injection route" ;
    oboInOwl:hasSynonym "I.M." ;
    a owl:Class ;
    rdfs:label "intramuscular route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0001134
    ] .

obo:VO_0000341
    obo:IAO_0000115 "rounte of administration that located in nose." ;
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasSynonym "I.N." ;
    a owl:Class ;
    rdfs:label "intranasal route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0000004
    ] .

obo:VO_0000342
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "intranasal route by drop" ;
    rdfs:subClassOf obo:VO_0000341 .

obo:VO_0000343
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "intranasal route by spray" ;
    rdfs:subClassOf obo:VO_0000341 .

obo:VO_0000344
    obo:IAO_0000115 "a route of administration that located in the peritoneum." ;
    obo:IAO_0000117 "YL" ;
    dc:creator "YH" ;
    a owl:Class ;
    rdfs:label "intraperitoneal route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0002358
    ] .

obo:VO_0000345
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis WR201" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000346
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pWRG7077 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000347
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus bacA mutant" ;
    a owl:Class ;
    rdfs:label "Brucella abortus bacA mutant" ;
    rdfs:seeAlso "PMID: 17196866" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000348
    obo:IAO_0000117 "Kallan Roan, Oliver He"^^xsd:anyURI ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm181975.htm"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza A (H1N1) 2009 Monovalent Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "CSL Limited"^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization of persons ages 6 months and older against influenza disease caused by pandemic (H1N1) 2009 virus."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM182401.pdf"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Influenza A (H1N1) 2009 Monovalent Vaccine (CSL Limited)" ;
    rdfs:subClassOf obo:VO_0003211, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000689 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000349
    obo:IAO_0000117 "Kallan Roan, Oliver He"^^xsd:anyURI ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm181970.htm"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza A (H1N1) 2009 Monovalent Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "MedImmune LLC"^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization of individuals 2-49 years of age against influenza disease caused by pandemic (H1N1) 2009 virus."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM182406.pdf"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Influenza A (H1N1) 2009 Monovalent Vaccine ( MedImmune LLC)" ;
    rdfs:subClassOf obo:VO_0003211, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003020
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000694 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000350
    obo:IAO_0000117 "MC, YH" ;
    a owl:Class ;
    rdfs:label "Arepanrix" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000351
    obo:IAO_0000115 "A synthetic vaccine adjuvant that is PCPP salt." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Adjumer", "PCPP salt", "polyidi (carboxylatophenoxy) lphosphazene", "polyphosphazene" ;
    obo:IAO_0000119 "PMID: 75551218" ;
    a owl:Class ;
    rdfs:label "Adjumer vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0000352
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "Megan Egg is a Salmonella vaccine that that consists of a double gene-deleted S. enterica serovar Typhimurium strain and is formulated fro immunization of pullets. Megan Egg contains the same Megan Vac1 organism but Megan Vac1 is used for younger birds (broilers).", "WEB: http://www.fda.gov/ohrms/dockets/dockets/00n0504/00N-0504_emc-001650-02.pdf" ;
    a owl:Class ;
    rdfs:label "Megan Egg" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000353
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pWRM DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000354
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID: 16481077" ;
    a owl:Class ;
    rdfs:label "B. ovis microparticle subunit vaccine" ;
    rdfs:subClassOf obo:VO_0002925, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000355
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pzz DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000356
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pME18100 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000357
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pVIVO2 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000358
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Brucella rSurA protein vaccine", "Brucella recombinant SurA protein" ;
    a owl:Class ;
    rdfs:label "Brucella recombinant SurA protein vaccine" ;
    rdfs:seeAlso "PMID: 17686554" ;
    rdfs:subClassOf obo:VO_0001221, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000359
    obo:IAO_0000115 "a viral vaccine vector that uses a lentivirus as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "lentivirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11646" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0000360
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pcDNA1.1/Amp DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000361
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced leukocyte activation" ;
    rdfs:subClassOf obo:VO_0000180 .

obo:VO_0000362
    obo:IAO_0000115 "a licensed human vaccine that is licensed in the USA." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htm" ;
    a owl:Class ;
    rdfs:label "USA licensed human vaccine" ;
    rdfs:subClassOf obo:VO_0000635 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000194
    ] .

obo:VO_0000363
    obo:IAO_0000115 "A vaccine that is licensed for commercial use." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ] .

obo:VO_0000364
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pRK7 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000365
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "lipopolysaccharide of pathogen organism as vaccine component" ;
    rdfs:subClassOf obo:VO_0000000 .

obo:VO_0000366
    obo:IAO_0000115 """a vaccine adjuvant that contains particles made up of concentric lipid membranes containing phospholipids and other lipids in a bilayer configuration separated by aqueous compartments. It is a relatively stable but non-covalently-bound complex of saponin adjuvant Quil-A, cholesterol and amphipathic antigen in a molar ratio of approximately 1:1:1. The spectrum of viral capsid antigens and non-viral amphipathic antigens of relevance for human vaccination, incorporated into ISCOMs, comprises influenza, measles, rabies, gp340 from EB-virus, gp120 from HIV, Plasmodium falciparum and Trypanosoma cruzi. Ref:
http://www.vaccination.inoz.com/adjuvants.html.""" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "liposome-based vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001356 .

obo:VO_0000367
    obo:IAO_0000115 "A live vaccine that is made from microbes that have been attenuated (weakened) in the laboratory so that they can't cause disease." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "attenuated vaccine" ;
    a owl:Class ;
    rdfs:label "live attenuated vaccine" ;
    rdfs:subClassOf obo:VO_0000001 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ] .

obo:VO_0000368
    obo:IAO_0000115 "a vaccine organism that is live" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live vaccine organism" ;
    rdfs:subClassOf obo:VO_0000506, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001145
    ] .

obo:VO_0000369
    obo:IAO_0000115 "a 'has vaccine component' relation that specifies the plasmid used for development of a particular DNA vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has DNA vaccine plasmid"@en ;
    rdfs:subPropertyOf obo:VO_0000520 .

obo:VO_0000370
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live virulent vaccine" ;
    rdfs:subClassOf obo:VO_0000001 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000612
    ] .

obo:VO_0000371
    obo:IAO_0000115 "quaternary vaccination is a vaccination that is performed at the fourth  time in a row." ;
    obo:IAO_0000117 "YH, Thom Todd" ;
    a owl:Class ;
    rdfs:label "quaternary vaccination" ;
    rdfs:subClassOf obo:VO_0000708, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000062 ;
        owl:someValuesFrom obo:VO_0000332
    ] .

obo:VO_0000372
    obo:IAO_0000115 "A vaccine that is used to improve conception." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "profertility vaccine"@en ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0000373
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella recombinant DnaK protein vaccine" ;
    rdfs:seeAlso "PMID: 17686554" ;
    rdfs:subClassOf obo:VO_0001221, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000374
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "divalent DNA B. abortus vaccine using L7/L12 and Omp16" ;
    rdfs:seeAlso "PMID: 16622210" ;
    rdfs:subClassOf obo:VO_0001225, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000375
    obo:IAO_0000112 "'Mycobacterium avium relA mutant vaccine' includes a gene mutation of relA from virulent Mycobacterium avium. " ;
    obo:IAO_0000115 "A live attenuated vaccine prepraration process that is performed by mutation of a gene(s) from a virulent pathogen." ;
    obo:IAO_0000117 "YH, YL, ZX" ;
    a owl:Class ;
    rdfs:label "preparation of gene mutant vaccine"@en ;
    rdfs:subClassOf obo:VO_0000718 .

obo:VO_0000376
    obo:IAO_0000115 "a route of administration that is through the membrane covering the muscles and nerves at the back of the eyeball"@en ;
    dc:creator "Y.L." ;
    a owl:Class ;
    rdfs:label "subtenon route" ;
    rdfs:seeAlso "http://ncim.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20MetaThesaurus&code=CL426248" ;
    rdfs:subClassOf obo:VO_0000574 .

obo:VO_0000377
    obo:IAO_0000115 "an oral route of administration that is underneath the tongue."@en ;
    a owl:Class ;
    rdfs:label "sublingual route" ;
    rdfs:seeAlso "http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38300" ;
    rdfs:subClassOf obo:VO_0000886 .

obo:VO_0000378
    dc:creator "Y.L."@en ;
    a owl:Class ;
    rdfs:label "intravaginal route" ;
    rdfs:subClassOf obo:VO_0000574 .

obo:VO_0000379
    a owl:Class ;
    rdfs:label "intravaginal vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000378
    ] .

obo:VO_0000380
    a owl:Class ;
    rdfs:comment "YH" ;
    rdfs:label "subtenon vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000376
    ] .

obo:VO_0000381
    a owl:Class ;
    rdfs:label "sublingual vaccination" ;
    rdfs:subClassOf obo:VO_0003021, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000377
    ] .

obo:VO_0000382
    a owl:Class ;
    rdfs:label "pharyngeal mucosal vaccination" ;
    rdfs:subClassOf obo:VO_0003021, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000953
    ] .

obo:VO_0000383
    obo:IAO_0000115 "a vaccine-induced T cell interferon-gramm production that results from the addition of a vaccine adjuvant" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced, adjuvant boosted T cell interferon-gramm production"@en ;
    rdfs:subClassOf obo:VO_0000273 .

obo:VO_0000384
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 """PMID: 18472194
""" ;
    a owl:Class ;
    rdfs:label "IL-15 plasmid vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001342 .

obo:VO_0000385
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus DNA vaccine encoding L7/L12 and P39" ;
    a owl:Class ;
    rdfs:label "Brucella abortus DNA vaccine encoding L7/L12 and P39" ;
    rdfs:seeAlso "PMID: 16537031" ;
    rdfs:subClassOf obo:VO_0001225, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000386
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "attenuated Brucella abortus with deletion of znuA" ;
    rdfs:seeAlso "PMID: 16790759" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000387
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "mucosal immune response to vaccine" ;
    rdfs:subClassOf obo:VO_0000408 .

obo:VO_0000388
    obo:IAO_0000115 "a microbial derivative vaccine adjuvant that is derived from E. coli heat labile toxin LT." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "E. coli LT toxin derived vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0000389
    obo:IAO_0000115 "viral vaccine that is used to protect against Feline panleukopenia virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline panleukopenia virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10786
    ] .

obo:VO_0000390
    obo:IAO_0000115 "Vaccine that used for immunizing birds."@en ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "birds vaccine" ;
    rdfs:subClassOf obo:VO_0001461, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8825
    ] .

obo:VO_0000391
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Leptospira spp. infection" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Leptospira spp. vaccine" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000165
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_171
            ]
        )
    ] .

obo:VO_0000392
    obo:IAO_0000115 "a Campylobacter bacterial vaccine that is used to protect against Campylobacter fetus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Campylobacter fetus vaccine" ;
    rdfs:subClassOf obo:VO_0000568, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_196
    ] .

obo:VO_0000393
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Pseudomonas aeruginosa infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pseudomonas aeruginosa vaccine" ;
    rdfs:subClassOf obo:VO_0000766, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0000394
    obo:IAO_0000115 "a Bordetella bacterial vaccine that is used to protect against Bordetella bronchiseptica infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bordetella bronchiseptica vaccine" ;
    rdfs:subClassOf obo:VO_0000587, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_518
    ] .

obo:VO_0000395
    obo:IAO_0000117 "YH, YL, ZX" ;
    obo:IAO_0000118 "a vaccine organism that is inactived/killed", "killed vaccine organism" ;
    a owl:Class ;
    rdfs:label "inactivated vaccine organism" ;
    rdfs:subClassOf obo:VO_0000506, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0000396
    a owl:Class ;
    rdfs:label "licensed rabbit vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9986
    ] .

obo:VO_0000397
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "neutralizing antibody role" ;
    rdfs:subClassOf obo:VO_0000148 .

obo:VO_0000398
    obo:IAO_0000112 "A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant vjbR::Tn5 (BMEII1116) delivered using alginate microspheres that is coated with a protein of the parasite Fasciola hepatica (vitelline protein B [VpB]). PMID: 18362129." ;
    obo:IAO_0000115 "A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant delivered using a microsphere delivery system." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "The deletion of vjbR gene in Brucella melitensis strain 16M made a live attenuated vaccine and provided significance protection against mice" ;
    rdfs:label "microencapsulated B. melitensis mutant vaccine" ;
    rdfs:seeAlso "PMID: 18362129" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000399
    obo:IAO_0000115 "a vaccine-induced adjuvant boosted T cell interferon-gramm production that results from the addition of a IL-15 vaccine adjuvant" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID:  18472194" ;
    a owl:Class ;
    rdfs:label "vaccine-induced T cell interferon-gramm production boosted by IL-15 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000383 .

obo:VO_0000400
    obo:IAO_0000115 "a vaccine that contains one vaccine for priming and at least one other vaccine for boosting. " ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "prime-boost vaccine"@en ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0000401
    obo:IAO_0000115 "a vaccine that contains one DNA vaccine for priming and at least one other vaccine for boosting. " ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "prime-boost vaccine with DNA vaccine priming"@en ;
    rdfs:subClassOf obo:VO_0000400 .

obo:VO_0000402
    obo:IAO_0000119 "PMID: 12848591" ;
    obo:IAO_0000600 "a prophylactic vaccine developed by VaxGen company to against HIV-1 consisting of two recombinant gp120 surface protein from different HIV-1 strains." ;
    a owl:Class ;
    rdfs:label "AIDSVAX" ;
    rdfs:seeAlso "http://en.wikipedia.org/wiki/AIDSVAX" ;
    rdfs:subClassOf obo:VO_0000295 .

obo:VO_0000403
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "complex of porin and S-LPS from  B. abortus strain 2308" ;
    a owl:Class ;
    rdfs:label "porin-S-LPS from B. abortus strain 2308" ;
    rdfs:seeAlso "PMID: 2844673" ;
    rdfs:subClassOf obo:VO_0001221, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000404
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus RB51WboA" ;
    a owl:Class ;
    rdfs:label "Brucella abortus RB51WboA" ;
    rdfs:seeAlso "PMID: 15327798" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000405
    obo:IAO_0000116 "link to another well-known study: VAX004", "linkto the clinical trail database by : ClinicalTrials.gov Identifier:	NCT00002441" ;
    dc:description """The AIDSVAX that is bicovalent vaccine including two kinds of gp120 protein: MN rgp120/HIV-1 and GNE8 rgp120/HIV-1 (MN and GNE8 are strain names).
Resource: ClinicalTrials.gov"""@en ;
    a owl:Class ;
    rdfs:label "AIDSVAX B/B" ;
    rdfs:subClassOf obo:VO_0000402 .

obo:VO_0000406
    a owl:Class ;
    rdfs:label "AIDSVAX B/E" ;
    rdfs:subClassOf obo:VO_0000402 .

obo:VO_0000407
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant O. anthropi 49237SOD" ;
    rdfs:seeAlso "PMID: 11953393" ;
    rdfs:subClassOf obo:VO_0000957, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000166
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000408
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "organ or tissue specific immune response to vaccine" ;
    rdfs:subClassOf obo:VO_0000287 .

obo:VO_0000409
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed horse vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9788
    ] .

obo:VO_0000410
    obo:IAO_0000115 "Pandemrix is an influenza vaccine for influenza pandemics, such as the H1N1 2009 flu pandemic colloquially called the swine flu. The vaccine was developed by GlaxoSmithKline and patented in September 2006."@en ;
    obo:IAO_0000118 "Pandemrix H1N1"@en ;
    obo:IAO_0000119 "http://en.wikipedia.org/wiki/Pandemrix"@en ;
    obo:IAO_0000232 "TODO: the component 'egg protein' and 'sodium deoxycholate' is not added yet."@en ;
    dc:creator "YL"@en ;
    a owl:Class ;
    rdfs:comment "ATC code	J07BB02"@en, """As well as the active antigen derived from A/California/7/2009 (H1N1), the vaccine contains an immunologic adjuvant AS03 which consists of DL-α-tocopherol (vitamin E), squalene and polysorbate 80.
Thiomersal (thimerosal) is added as a preservative. Being manufactured in chicken eggs, it contains trace amounts of egg proteins. Additional important non-medicinal ingredients are formaldehyde, sodium deoxycholate, and sucrose. (http://en.wikipedia.org/wiki/Pandemrix)"""@en ;
    rdfs:label "Pandemrix"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001346
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003036
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_114727
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000411
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. melitensis Bp26 and trigger factor" ;
    a owl:Class ;
    rdfs:label "B. melitensis Bp26 and Tf protein vaccine" ;
    rdfs:seeAlso "PMID: 17239499" ;
    rdfs:subClassOf obo:VO_0001223, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000412
    obo:IAO_0000115 "A Brucella subunit vaccine that uses recombinant Brucella melitensis 16M P39, a putative periplasmic binding protein. PMID: 11447155." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis P39 recombinant protein vaccine" ;
    rdfs:seeAlso "PMID: 11447155" ;
    rdfs:subClassOf obo:VO_0001223, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000525 ;
        owl:someValuesFrom obo:VO_0010948
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000413
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "rBLSOmp31" ;
    a owl:Class ;
    rdfs:label "recombinant chimera BLSOmp31" ;
    rdfs:seeAlso "PMID: 17442465" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000414
    obo:IAO_0000115 "Panvax is an H1N1 unadjuvanted monovalent vaccine." ;
    obo:IAO_0000117 "MC, YH" ;
    obo:IAO_0000119 "WEB: http://www.infowars.com/h1n1-panvax-training-powerpoint-received-by-health-care-workers-in-australia/" ;
    a owl:Class ;
    rdfs:label "Panvax" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_114727
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000689 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000415
    obo:IAO_0000117 "YL,YH" ;
    obo:IAO_0000119 "Page 73, Chapter 6, Vaccine, 5th Edition. EXPERT CONSULT by Plotkin SA., et. al. 2008", "a role inheres in a material entity, that has been added into a vaccine's formulation by the manufacture for a specific purpose. For example: adjuvant to enhance the effect of immunogen, perservatives, stablizers and those materials added for affecting PH and isotonicity." ;
    a owl:Class ;
    rdfs:label "vaccine additive role" ;
    rdfs:subClassOf obo:VO_0000617 .

obo:VO_0000416
    obo:IAO_0000115 "route of administration that is located in the vein" ;
    obo:IAO_0000117 "YH, Thom Todd" ;
    oboInOwl:hasSynonym "i.v." ;
    a owl:Class ;
    rdfs:label "intravenous route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0001638
    ] .

obo:VO_0000417
    obo:IAO_0000115 "A vaccine that protects against some protozoan disease."^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "parasite vaccine", "parasitic vaccine" ;
    a owl:Class ;
    rdfs:label "protozoan vaccine" ;
    rdfs:seeAlso "MeSH: D016052" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2759
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2759
    ] .

obo:VO_0000418
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine injection 0.5mL vial" ;
    obo:IAO_0000119 "WEB: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm176044.htm" ;
    a owl:Class ;
    rdfs:comment "Product Name: Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine  injection 0.5mL vial"^^xsd:string, "Trade Name: Menactra" ;
    rdfs:label "Menactra injection 0.5mL vial" ;
    rdfs:seeAlso "SNOMEDCT: 416532007; UMLS_CUI:C1563043" ;
    rdfs:subClassOf obo:VO_0000071, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001256
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015064
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015066
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015068
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015071
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000419
    obo:IAO_0000115 "a Varicella-zoster virus vaccine that is live attenuated." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Varicella-zoster virus live vaccine" ;
    rdfs:seeAlso "SNOMEDCT: 412530002; ULMS_CUI: C0770687" ;
    rdfs:subClassOf obo:VO_0000669 .

obo:VO_0000420
    obo:IAO_0000115 "a vaccine component that originates from an organism such as a pathogen or a modified organism." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "pathogen organism component in vaccine" ;
    rdfs:subClassOf obo:VO_0000179 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Class ;
                owl:unionOf (obo:OBI_0100026
                    [
                        a owl:Restriction ;
                        owl:onProperty obo:BFO_0000050 ;
                        owl:someValuesFrom obo:OBI_0100026
                    ]
                )
            ]
        )
    ] .

obo:VO_0000421
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus pcDNA-BLS" ;
    a owl:Class ;
    rdfs:label "Brucella abortus pcDNA-BLS" ;
    rdfs:subClassOf obo:VO_0001225, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010927
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000422
    obo:IAO_0000115 "a cancer vaccine that is used against melanoma, a malignant tumor of melanocytes." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "SNOMEDCT: 373869007; UMLS_CUI: C0796561" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Melanoma" ;
    a owl:Class ;
    rdfs:label "melanoma vaccine" ;
    rdfs:subClassOf obo:VO_0000177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001011 ;
        owl:someValuesFrom obo:DOID_1909
    ] .

obo:VO_0000423
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "escheriosome-encapsulated B. abortus L7/L12" ;
    a owl:Class ;
    rdfs:label "escheriosome-mediated delivery of B. abortus L7/L12" ;
    rdfs:seeAlso "PMID: 17931756" ;
    rdfs:subClassOf obo:VO_0001221, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000424
    obo:IAO_0000115 "a pneumococcal vaccine that is formed using polyvalent polysaccharides" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.who.int/vaccines/en/pneumococcus.shtml" ;
    a owl:Class ;
    rdfs:comment "The most common form of the polyvalent pneumococcal vaccine is called the protein-polysaccharide combinations which is known as conjugate vaccines and contain 7–11 selected polysaccharides bound to a protein carrier. The protein-polysaccharide combinations are able to induce a T-cell dependent immune response. These vaccines are likely to be protective even in children under two years of age, and may reduce pneumococcal transmission through a herd effect." ;
    rdfs:label "polyvalent pneumococcal vaccine" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000888
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001254
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000425
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/10700309" ;
    a owl:Class ;
    rdfs:comment "a Staphyloccoccus vaccine that is made using engineered toxoid." ;
    rdfs:label "Staphylococcus toxoid vaccine" ;
    rdfs:subClassOf obo:VO_0000770 .

obo:VO_0000426
    obo:IAO_0000115 "period of persistence of vaccine induced immune response is a temporal interval during which a vaccine-induced immune response continuously exists. This term is related to the process 'persistence of vaccine induced immune response'." ;
    obo:IAO_0000117 "YH, MC" ;
    a owl:Class ;
    rdfs:label "period of persistence of vaccine induced immune response" ;
    rdfs:subClassOf obo:BFO_0000038 .

obo:VO_0000427
    obo:IAO_0000115 "A vaccine clinical trial that investigates the safety profile of a vaccine in a small group (10-50) of healthy volunteers." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "phase 1 vaccine trial" ;
    rdfs:subClassOf obo:VO_0000596 .

obo:VO_0000428
    obo:IAO_0000115 "A vaccine clinical trial that studies vaccine efficacy with a target population (numbering 50-100). Different dosage levels will also be explored at this stage to determine the optimum dose." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "phase 2 vaccine trial" ;
    rdfs:subClassOf obo:VO_0000596 .

obo:VO_0000429
    obo:IAO_0000115 "A vaccine clinical trial that takes the trial to a large-scale safety and efficacy study in a relevant patient population, usually in excess of 3,000." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "phase 3 vaccine trial" ;
    rdfs:subClassOf obo:VO_0000596 .

obo:VO_0000430
    obo:IAO_0000115 "The final stage of vaccine clinical evaluation. Phase IV occurs after a vaccine or therapy is licensed and is being used by large numbers of people. These studies are not always required or completed." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "phase 4 vaccine trial" ;
    rdfs:subClassOf obo:VO_0000596 .

obo:VO_0000431
    obo:IAO_0000115 "Seven F. tularensis proteins including IglC (rLm/iglC) were expressed in recombinant L. monocytogenes (rLm) vaccines. These 7 F. tularensis proteins are: AcpA, Bfr, DnaK, GroEL, IglC, Pld and KatG from SchuS4 strain." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "rLm/iglC" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0000432
    obo:IAO_0000115 "A subunit nontypeable H. influenzae vaccine that uses Hap protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "nontypeable H. influenzae Hap Protein Vaccine" ;
    rdfs:seeAlso "PMID: 15557618" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010917
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000433
    obo:IAO_0000115 "a Smallpox virus vaccine that uses vaccinia virus" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Vaccinia" ;
    a owl:Class ;
    rdfs:comment "Vaccinia virus is well known for its role as a vaccine that helped eradicate the smallpox disease, making it the first human disease to be successfully eradicated by science." ;
    rdfs:label "vaccinia virus vaccine" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003052
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000686 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000434
    obo:IAO_0000115 "Mixed Bacterial Vaccine (MBV, Coley's Toxins) is a historical, vaguely defined preparation of heat-inactivated Streptococcus pyogenes and Serratia marcescens used as non-specific immunotherapy in the treatment of cancer." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Coley's Toxins" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/22847809" ;
    a owl:Class ;
    rdfs:label "Mixed Bacterial Vaccine" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0000435
    obo:IAO_0000115 "a vaccine component that is composed of a plasmid and used in the generation of a DNA vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine plasmid vector" ;
    rdfs:subClassOf obo:VO_0000179 .

obo:VO_0000436
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "pCIBLSOmp31" ;
    a owl:Class ;
    rdfs:label "B. melitensis DNA vaccine encoding Omp31 boosted with Omp31" ;
    rdfs:subClassOf obo:VO_0001226, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000437
    obo:IAO_0000115 "a bacterial vaccine against Moraxella bovis infection. Moraxella bovis is a Gram-negative, aerobic, oxidase-positive diplococcus that is implicated in infectious bovine keratoconjunctivitis, an eye disease of cattle, also colloquially known as Pink Eye." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Moraxella_bovis" ;
    a owl:Class ;
    rdfs:label "Moraxella bovis vaccine" ;
    rdfs:subClassOf obo:VO_0000165 .

obo:VO_0000438
    obo:IAO_0000117 "YH", "a Moraxella bovis vaccine that is prepared using a bacterial bacterin." ;
    a owl:Class ;
    rdfs:label "Moraxella bovis bacterin vaccine" ;
    rdfs:seeAlso "UMLS_CUI: C0310839; SNOMEDCT: 39730006" ;
    rdfs:subClassOf obo:VO_0000437 .

obo:VO_0000439
    obo:IAO_0000115 "a USA licensed vaccine role that indicates the vaccine is for veterinary uses." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "USDA licensed veterinary vaccine role"@en ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000551
            obo:VO_0000812
        )
    ] .

obo:VO_0000440
    obo:IAO_0000112 "WEB: http://news.prnewswire.com/ViewContent.aspx?ACCT=109&STORY=/www/story/09-15-2009/0005094621&EDATE @2009/10/06", "WEB: http://www.examiner.com/x-7707-Infectious-Disease-Examiner~y2009m9d15-News-Release-H1N1-vaccines-get-FDA-approval-expected-to-be-available-in-4-weeks @2009/10/06. H1N1 vaccines get FDA approval. Food and Drug Administration announced today that it has approved four vaccines against the 2009 H1N1 influenza virus. Obtaining FDA licensure of this vaccine for A (H1N1) pandemic response is a key milestone that will enable Sanofi Pasteur to provide a licensed vaccine to the U.S. government to support pandemic immunization efforts" ;
    obo:IAO_0000115 "vaccine approval process is a processual entity that involves approval of a vaccine." ;
    obo:IAO_0000117 "YH, ZX, AR, and MC" ;
    obo:IAO_0000118 "vaccine product approval process" ;
    obo:IAO_0000119 "WEB:  http://energycommerce.house.gov/images/stories/Documents/PDF/publications/109_health.pdf @2009/10/06. This is the US Health Law which includes a section about vaccine.", "WEB: http://www.hhs.gov/nvpo/factsheets/fs_tableII_doc2.htm @2009/10/06 #Following the FDA's review of a license application, the sponsor and the FDA may present their findings to the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC). This non-FDA expert committee (scientists, physicians, biostatisticians, and a consumer representative) provides advice to the Agency regarding the safety and efficacy of the vaccine for the proposed indication." ;
    a owl:Class ;
    rdfs:label "vaccine approval process" ;
    rdfs:subClassOf obo:OBI_0000011, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000363
    ] .

obo:VO_0000441
    obo:IAO_0000115 "vaccine candidate role is the role of a material entity in an investigation, which has not been experimentally or clinically verified to induce a protection or treatment in vivo in a host organism. " ;
    obo:IAO_0000117 "BP, YH", "This role should be a subclass of 'test substance role', which will be mireoted from OBI by OntoFox." ;
    a owl:Class ;
    rdfs:label "vaccine candidate role" ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0000442
    obo:IAO_0000115 "CFU measurement assay is an assay that measures the colony forming unit (CFU) of a bacterium in a specific location (e.g., spleen of a mouse)." ;
    obo:IAO_0000117 "YH, MC" ;
    a owl:Class ;
    rdfs:label "CFU measurement assay" ;
    rdfs:subClassOf obo:OBI_0000070, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000189
    ] .

obo:VO_0000443
    obo:IAO_0000115 """vaccine effectiveness rate is a measurement datum that measues the vaccine effectiveness.  It is assessed with respect to prevention of the disease against which the vaccine is given. 
One simple method to estimate vaccine effectiveness is to use routine data on notifications of disease cases in vaccinated and unvaccinatted children and to compare the porportion of cases vaccinated with the vaccine covervage among the same age group in the general population. If p is the proportion vaccinated in the population and c is the proportion of cases reported to be vaccinated, then
VE = (p-c)/p(1-c) x 100%.""" ;
    obo:IAO_0000117 "YH, MC" ;
    obo:IAO_0000119 "Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71.", "WEB: http://en.wikipedia.org/wiki/Influenza_vaccine" ;
    a owl:Class ;
    rdfs:label "vaccine effectiveness rate" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0000444
    obo:IAO_0000117 "YH, ZX", "vaccine licensing is a vaccine approval process that involves in licensing a vaccine." ;
    a owl:Class ;
    rdfs:label "vaccine licensing" ;
    rdfs:subClassOf obo:VO_0000440 .

obo:VO_0000445
    obo:IAO_0000115 "infection_of is a relation between a disorder and an infectious pathogen." ;
    obo:IAO_0000116 """The relation 'infection_of' is introduced to represent an infection caused by an infectious pathogen. A pathogen infection is a disorder. Since the number of pathogens is large, there are numerous infections. To make the description of a specific infection simple, the shortcut term 'infection_of' is defined: 
infection_of X = infection and has_part some (organism X and has_disposition some infectious disposition)""" ;
    obo:IAO_0000117 "YH, XZ, MC, BP, AR" ;
    a owl:ObjectProperty ;
    rdfs:label "infection_of" .

obo:VO_0000446
    obo:IAO_0000117 "YH, XZ" ;
    a owl:Class ;
    rdfs:label "licensed chicken vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0000447
    obo:IAO_0000115 "a viral vaccine vector that uses an poxvirus as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "poxvirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10240" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0000448
    obo:IAO_0000115 "a Salmonella vaccine against infection with S. paratyphi, which causes paratyphoid fevers. Paratyphoid fevers are a group of enteric illnesses caused by serotypic strains of the Salmonella genus of bacteria, S. Paratyphi." ;
    obo:IAO_0000118 "paratyphoid vaccine" ;
    obo:IAO_0000119 "WED: http://en.wikipedia.org/wiki/Paratyphoid_fever" ;
    a owl:Class ;
    rdfs:label "Salmonella paratyphi vaccine" ;
    rdfs:subClassOf obo:VO_0000768 .

obo:VO_0000449
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.jefferspet.com/%252332moraxella-bovis-bacterin-piliguard-pinkeye-1-trivalent/camid/liv/cp/16435/" ;
    a owl:Class ;
    rdfs:label "Moraxella Bovis Bacterin Piliguard Pinkeye-1 Trivalent" ;
    rdfs:subClassOf obo:VO_0000438, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000893 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000450
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Brucella vaccine using nonpathogenic alphaproteobacteria" ;
    a owl:Class ;
    rdfs:label "NPAP Brucella vaccine" ;
    rdfs:seeAlso "PMID: 17715332" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000451
    obo:IAO_0000115 "A viral vaccine that protects against infection with Parainfluenza 3 virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Parainfluenza 3 virus vaccine" ;
    rdfs:seeAlso "UMLS_CUI: C0310756; SNOMEDCT: 82867008" ;
    rdfs:subClassOf obo:VO_0000749 .

obo:VO_0000452
    obo:IAO_0000115 "preventive vaccine function is a vaccine function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which protects against a specific disorder." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "prophylactic vaccine function" ;
    a owl:Class ;
    rdfs:label "preventive vaccine function" ;
    rdfs:subClassOf obo:VO_0000278, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000054 ;
        owl:someValuesFrom obo:VO_0000002
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000054 ;
        owl:someValuesFrom obo:VO_0000495
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000054 ;
        owl:someValuesFrom obo:VO_0000496
    ] .

obo:VO_0000453
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "prime boost regimen" ;
    rdfs:subClassOf obo:VO_0000572 .

obo:VO_0000454
    obo:IAO_0000116 "Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is a major problem for the poultry industry in the world." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PubMed: http://www.ncbi.nlm.nih.gov/pubmed/16863080", "WEB: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=134" ;
    a owl:Class ;
    rdfs:label "APEC vaccine using GST-Iss fusion protein" ;
    rdfs:subClassOf obo:VO_0001156 .

obo:VO_0000455
    obo:IAO_0000115 "a vaccine that is used for prevention against a disease."^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "prophylactic vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000085 ;
        owl:someValuesFrom obo:VO_0000452
    ] .

obo:VO_0000456
    obo:IAO_0000115 "Protection efficacy is an efficiency that is associated with protection by a biological product (e.g., vaccine) against a disease." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "protection efficacy" ;
    rdfs:subClassOf obo:PATO_0001029 .

obo:VO_0000457
    obo:IAO_0000115 "Protective antigen is an antigen that stimulates protective immunity when used in vivo." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "protective antigen role" ;
    rdfs:subClassOf obo:OBI_0000237 .

obo:VO_0000458
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "E. coli heat-labile enterotoxin B-subunit (LB-T) vaccine" ;
    a owl:Class ;
    rdfs:label "E. coli LB-T vaccine" ;
    rdfs:seeAlso "PMID: 11500434" ;
    rdfs:subClassOf obo:VO_0000041, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000459
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli O157:H7 subunit vaccine expressing Esps and Tir" ;
    rdfs:seeAlso "PMID: 14670317" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010940
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0000460
    obo:IAO_0000115 "an influenza virus vaccine against equine influenza viral infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "equine influenza vaccine" ;
    rdfs:seeAlso "UMLS_CUI: C0310723; SNOMEDCT: 51393000" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ] .

obo:VO_0000461
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "avian influenza vaccine" ;
    rdfs:seeAlso "an influenza vaccine for avian use" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0000462
    obo:IAO_0000115 "an object property that specifies a process that is induced by vaccination of a vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:label "induced by vaccination of"@en ;
    rdfs:range obo:VO_0000001 .

obo:VO_0000463
    obo:IAO_0000115 "a bacterial vaccine against infection with Coxiella burnetii which causes Q fever" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Q fever vaccine" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Q_fever" ;
    a owl:Class ;
    rdfs:label "Coxiella burnetii vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_777
    ] .

obo:VO_0000464
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "protein of pathogen organism as vaccine component" ;
    rdfs:subClassOf obo:VO_0000000 .

obo:VO_0000465
    obo:IAO_0000115 "a S. aureus vaccine that uses bacterin as the protective antigen. " ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "Staphylococcus aureus bacterin vaccine"@en ;
    rdfs:seeAlso "UMLS_CUI: C0310856; SNOMEDCT: 52974007" ;
    rdfs:subClassOf obo:VO_0002502 .

obo:VO_0000466
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "soybean-expressed E. coli LTB vaccine" ;
    rdfs:seeAlso "PMID: 17188785" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010943
    ] .

obo:VO_0000467
    obo:IAO_0000115 "a S. aureus vaccine that uses the bacterial phage lysate as the protective antigen. " ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "Staphylococcus aureus phage lysate vaccine"@en ;
    rdfs:seeAlso "UMLS_CUI: C0311044; SNOMEDCT: 34679007" ;
    rdfs:subClassOf obo:VO_0002502 .

obo:VO_0000468
    obo:IAO_0000115 "a Mycoplasma gallisepticum vaccine that uses bacterin as the protective antigen" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Mycoplasma gallisepticum bacterin vaccine"@en ;
    rdfs:seeAlso "UMLS_CUI: C0310841; SNOMEDCT: 38267006" ;
    rdfs:subClassOf obo:VO_0000949 .

obo:VO_0000469
    obo:IAO_0000115 "a bacterial vaccine that uses bacterin from a bacterial strain isolated from a herd with a purpose to generate hard-specific vaccine. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://addisonlabs.com/products/autogenous-bacterins.php" ;
    a owl:Class ;
    rdfs:label "autogenous bacterin vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165 .

obo:VO_0000470
    obo:IAO_0000115 "an autogenous bacterin vaccine that is prepared for poultry use. " ;
    obo:IAO_0000119 "WEB: http://www.hygieialabs.com/autopoultry.html" ;
    a owl:Class ;
    rdfs:label "autogenous poulty bacterin vaccine"@en ;
    rdfs:subClassOf obo:VO_0000469 .

obo:VO_0000471
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "nontypeable H. influenzae vaccine" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:VO_0000472
    ] .

obo:VO_0000472
    obo:IAO_0000115 "Nontypeable Haemophilus influenzae (NTHi) is a nonencapsulated Haemophilus influenzae (a gram-negative bacterium). It is the cause of a number of human respiratory tract diseases, such as otitis media, sinusitis, bronchitis, and pneumonia." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "NTHi" ;
    a owl:Class ;
    rdfs:label "nontypeable Haemophilus influenzae" ;
    rdfs:subClassOf obo:NCBITaxon_727 .

obo:VO_0000473
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "rLP4/rLP6/UspA2" ;
    a owl:Class ;
    rdfs:label "non-typeable H. influenzae rLP4/rLP6 and Moraxella catarrhalis UspA2 protein vaccine" ;
    rdfs:seeAlso "PMID: 15308371" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010914
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000474
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "killed nontypeable H. influenzae whole-cell vaccine" ;
    rdfs:seeAlso "PMID: 1859055", "PMID: 1953532", "PMID: 2184330", "PMID: 2867396" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000475
    obo:IAO_0000115 "a Rabies virus vaccine against Rabies in animal" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "animal Rabies vaccine"@en ;
    rdfs:seeAlso "UMLS_CUI: C0310767; SNOMEDCT: 10495001" ;
    rdfs:subClassOf obo:VO_0000650 .

obo:VO_0000476
    obo:IAO_0000115 "a 'has vaccine component' relation that specifies a gene inserted to DNA vaccine plasmid for development of a particular DNA vaccine, and this gene encodes for a protein antigen. " ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has DNA vaccine antigen gene"@en ;
    rdfs:range obo:VO_0000787 ;
    rdfs:subPropertyOf obo:VO_0000520 .

obo:VO_0000477
    obo:IAO_0000115 "a Rabies virus vaccine against Rabies in human" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human Rabies vaccine"@en ;
    rdfs:seeAlso "UMLS_CUI: C0305066; SNOMEDCT: 3526007" ;
    rdfs:subClassOf obo:VO_0000650 .

obo:VO_0000478
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli vaccine using intimin polypeptide" ;
    rdfs:seeAlso "PMID: 14688094", "PMID: 17258324" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010944
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0000479
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "nontypeable H. influenzae cell membrane vaccine (CM-Hi)" ;
    rdfs:seeAlso "PMID: 10353870" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000480
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Nontypeable H. influenzae lipooligosaccharide-tetanus toxoid  conjugate vaccine" ;
    a owl:Class ;
    rdfs:label "nontypeable H. influenzae LOS-TT conjugate vaccine" ;
    rdfs:seeAlso "PMID: 12706701", "PMID: 9353024" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10150
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000481
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli subunit vaccine using IroN" ;
    rdfs:seeAlso "PMID: 17145948" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000482
    obo:IAO_0000115 "A vaccine preparation process that uses recombinant molecular technology to prepare recombinant protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of recombinant protein vaccine"@en ;
    rdfs:subClassOf obo:VO_0000717 .

obo:VO_0000483
    obo:IAO_0000115 "A subunit vaccine that is made using a part of whole organism as subunit for vaccine development. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "protein subunit vaccine" ;
    rdfs:subClassOf obo:VO_0000534 .

obo:VO_0000484
    obo:IAO_0000115 "A vaccine that uses a modified virus or bacterium to deliver genes that code for microbial antigens to cells of the body." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant vector vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000599
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000636
    ] .

obo:VO_0000485
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli subunit vaccine using CO393" ;
    rdfs:seeAlso "PMID: 17145948" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010965
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000486
    obo:IAO_0000117 "YH", "a chicken egg protein allergen where the protein allergen is ovalbumin, the main protein found in egg write, making up 60-65% of the total protein." ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Ovalbumin" ;
    a owl:Class ;
    rdfs:label "chicken ovalbumin egg protein allergen"@en ;
    rdfs:subClassOf obo:VO_0000912 .

obo:VO_0000487
    obo:IAO_0000117 "YH", "a S. typhi vaccine that is live and orally administerred" ;
    a owl:Class ;
    rdfs:label "typhoid live oral vaccine"@en ;
    rdfs:seeAlso "UMLS_CUI: C0359940; SNOMEDCT: 346696005" ;
    rdfs:subClassOf obo:VO_0000671 .

obo:VO_0000488
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli subunit vaccine using FyuA" ;
    rdfs:seeAlso "PMID: 14688094", "PMID: 17258324" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0000489
    obo:IAO_0000115 "a licensed vaccine role that is bears in a licensed human vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed human vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000630 .

obo:VO_0000490
    obo:IAO_0000115 "immunization is a processual entity that primes or modifies an adaptivie immune response to some antigens." ;
    obo:IAO_0000116 "YH, XZ, BP" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Immunization" ;
    a owl:Class ;
    rdfs:label "immunization" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0000491
    obo:IAO_0000115 "Active immunization is an immunization process that entails the introduction of a foreign molecule into the body, which causes the body itself to generate adaptive immunity against the target." ;
    obo:IAO_0000117 "YH, XZ" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Immunization" ;
    a owl:Class ;
    rdfs:comment """Active immunization entails the introduction of a foreign molecule into the body, which causes the body itself to generate immunity against the target. This immunity comes from the T cells and the B cells with their antibodies.
Active immunization can occur naturally when a person comes in contact with, for example, a microbe. If the person has not yet come into contact with the microbe and has no pre-made antibodies for defense (like in passive immunization), the person becomes immunized. The immune system will eventually create antibodies and other defenses against the microbe. The next time, the immune response against this microbe can be very efficient; this is the case in many of the childhood infections that a person only contracts once, but then is immune.
Artificial active immunization is where the microbe, or parts of it, are injected into the person before they are able to take it in naturally. If whole microbes are used, they are pre-treated, Attenuated vaccine. (Wikipedia)"""@en ;
    rdfs:label "active immunization" ;
    rdfs:subClassOf obo:VO_0000490 .

obo:VO_0000492
    obo:IAO_0000115 "Passive immunization is an immunization process where pre-synthesized elements of the immune system are transferred to an organism so that the body does not need to produce these elements itself." ;
    obo:IAO_0000117 "Currently, antibodies can be used for passive immunization. This method of immunization works very quickly. However, it is short lasting. The antibodies are naturally broken down. If there are no B cells to produce more antibodies, they will disappear.", "YH, XZ" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Immunization" ;
    a owl:Class ;
    rdfs:label "passive immunization" ;
    rdfs:subClassOf obo:VO_0000490, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:VO_0000585
    ] .

obo:VO_0000493
    obo:IAO_0000115 "natural active immunization is an active immunization that occur naturally when a person or animal comes in contact with antigens includeing microbes." ;
    obo:IAO_0000117 "YH, XZ" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Immunization" ;
    a owl:Class ;
    rdfs:label "natural active immunization" ;
    rdfs:subClassOf obo:VO_0000491 .

obo:VO_0000494
    obo:IAO_0000115 "artificial active immunization is an active immunization that occurs when a person or animal is vaccinated with a specific vaccine." ;
    obo:IAO_0000117 "YH, XZ" ;
    obo:IAO_0000118 "artificial active immunization" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Immunization" ;
    a owl:Class ;
    rdfs:label "vaccine immunization" ;
    rdfs:subClassOf obo:VO_0000491, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:VO_0001274
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000052 ;
                    owl:someValuesFrom obo:OBI_0100026
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:VO_0000001
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:VO_0000585
    ] .

obo:VO_0000495
    obo:IAO_0000115 "induction of adaptive immune response to antigen is an active immunization process that results in induction of adaptive immune response to some antigens, for example, in a vaccine." ;
    obo:IAO_0000117 "YH, XZ" ;
    a owl:Class ;
    rdfs:label "induction of adaptive immune response to antigen" ;
    rdfs:subClassOf obo:VO_0000491 .

obo:VO_0000496
    obo:IAO_0000115 "disorder prevention is a processual entity that prevents a disorder that is the physical basis of a disease." ;
    obo:IAO_0000117 "YH, XZ" ;
    a owl:Class ;
    rdfs:label "disorder prevention" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0000497
    obo:IAO_0000115 "disorder treatment is a processual entity that leads to treat a disorder that is the physical basis of a disease." ;
    obo:IAO_0000117 "YH, XZ" ;
    a owl:Class ;
    rdfs:label "disorder treatment" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0000498
    obo:IAO_0000115 "modification of adaptive immune response to antigen is an active immunization process that results in modification of an adaptive immune response to some antigens, for example, in a therapeutic vaccine." ;
    obo:IAO_0000117 "YH, XZ" ;
    a owl:Class ;
    rdfs:label "modification of adaptive immune response to antigen" ;
    rdfs:subClassOf obo:VO_0000491 .

obo:VO_0000499
    obo:IAO_0000117 "YH, XZ" ;
    a owl:Class ;
    rdfs:label "preventive infectious disease vaccine function" ;
    rdfs:subClassOf obo:VO_0000452 .

obo:VO_0000500
    obo:IAO_0000115 "infection disorder prevention is a process that prevents a disorder that is the physical basis of an infectious disease." ;
    obo:IAO_0000117 "YH, XZ" ;
    a owl:Class ;
    rdfs:label "infection disorder prevention" ;
    rdfs:subClassOf obo:VO_0000496 .

obo:VO_0000501
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli vaccine using verocytotoxin toxoid" ;
    rdfs:seeAlso "PMID: 17145948" ;
    rdfs:subClassOf obo:VO_0000963, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000502
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Inactivated ETEC expressing  expressing CFA/I and CFA/II" ;
    rdfs:seeAlso "PMID: 1612730" ;
    rdfs:subClassOf obo:VO_0000974, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000503
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed sheep vaccine"@en ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ] .

obo:VO_0000504
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a combination vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "whole organism vaccine role" ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000505
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "EHEC O157 subunit vaccine using his-tagged N-terminal intimin" ;
    rdfs:seeAlso "PMID: 1612730" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000506
    obo:IAO_0000115 "an organism that is used as part of a vaccine" ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "vaccine organism"@en ;
    rdfs:subClassOf obo:OBI_0100026, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000615
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:OBI_0100026
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000615
            ]
        )
    ] .

obo:VO_0000507
    obo:IAO_0000115 "a Canada  licensed vaccine role that indicates the vaccine is for veterinary uses." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Canada licensed veterinary vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000864 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000551
            obo:VO_0000864
        )
    ] .

obo:VO_0000508
    obo:IAO_0000115 "a diphtheria vaccine that uses diphtheria toxoid" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Diphtheria toxoid vaccine"@en ;
    rdfs:subClassOf obo:VO_0000735 .

obo:VO_0000509
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "nontypeable H. influenzae P5 peptide MVF/H3 vaccine" ;
    rdfs:seeAlso "PMID: 10603411" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10114
    ] .

obo:VO_0000510
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "nontypeable H. influenzae rTbpB vaccine" ;
    rdfs:seeAlso "PMID: 10225866" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10114
    ] .

obo:VO_0000511
    obo:IAO_0000116 "ACAM2007 is a vaccine candidate expressing CFA/II." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095642/" ;
    a owl:Class ;
    rdfs:label "ETEC vaccine ACAM2007" ;
    rdfs:subClassOf obo:VO_0000619, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000512
    obo:IAO_0000115 "a viral vaccine against a disease caused by a virus belong to Poxviridae. " ;
    a owl:Class ;
    rdfs:label "Pox vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10240
    ] .

obo:VO_0000513
    obo:IAO_0000115 "a Pox vaccine for Quail pox" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Quail pox vaccine"@en ;
    rdfs:seeAlso "UMLS_CUI: C0310765; SNOMEDCT: 10772009" ;
    rdfs:subClassOf obo:VO_0000512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_400570
    ] .

obo:VO_0000514
    obo:IAO_0000115 "a Salmonella vaccine against both typhoid caused by S. typhi and paratyphoid caused by S. paratyphi." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "typhoid-paratyphoid vaccine"@en ;
    rdfs:seeAlso "NDF-RT: N0000011275; UMLS_CUI: C0041470; SNOMEDCT: 52628005" ;
    rdfs:subClassOf obo:VO_0000768 .

obo:VO_0000515
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "rough phenotype" ;
    rdfs:subClassOf obo:VO_0000549 .

obo:VO_0000516
    obo:IAO_0000115 "a protein from human" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human protein"@en ;
    rdfs:subClassOf obo:PR_000000001 .

obo:VO_0000517
    obo:IAO_0000116 "ACAM2017 was derived from ACAM2007. Genes aroC, ompC, and ompF were deleted, while CS1 and pStrep were added.", "PMID: 17566016" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095642/" ;
    a owl:Class ;
    rdfs:label "ETEC vaccine ACAM2017" ;
    rdfs:subClassOf obo:VO_0000619, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000799 ;
        owl:someValuesFrom obo:VO_0010941
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000518
    obo:IAO_0000116 "This DNA vaccine contains the gene fragment encoding AAs 173-764 of PA." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine encoding PA63" ;
    rdfs:seeAlso "PMID: 9987172" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010872
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000519
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human ACPP"@en ;
    rdfs:seeAlso "GenBank: AC020633; Protein RefSeq: NP_001090 " ;
    rdfs:subClassOf obo:VO_0000516, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0000520
    obo:IAO_0000115 "an object property that defines a relation between a vaccine and its component" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "has vaccine component" .

obo:VO_0000521
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine encoding PA83 and LF" ;
    rdfs:seeAlso "PMID: 15342913" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010857
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9986
    ] .

obo:VO_0000522
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DAAV using PA and PGA" ;
    rdfs:seeAlso "PMID: 12960361" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010872
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000523
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "smooth phenotype" ;
    rdfs:subClassOf obo:VO_0000549 .

obo:VO_0000524
    obo:IAO_0000115 "an object property that specifies a vaccine antigen" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:ObjectProperty ;
    rdfs:comment "This relation only works for those vaccine antigen that is physically part of a vaccine preparation. It does not include those antigens that are not part of vaccine. For example, a protein antigen expressed in a DNA vaccine is not a part of vaccine pe ser. In this case, the vaccine expresses the protein, but the gene is part of the vaccine, not the protein. For the case, we can use the relation 'DNA vaccine expresses protein antigen' under the relation 'expresses'. " ;
    rdfs:label "has vaccine antigen" ;
    rdfs:subPropertyOf obo:VO_0000520 .

obo:VO_0000525
    obo:IAO_0000115 "a type of 'has vaccine antigen' relation that is specifically for vaccine protective protein antigen used in subunit vaccine development" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has subunit vaccine antigen" ;
    rdfs:subPropertyOf obo:VO_0000524 .

obo:VO_0000526
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "rPA with adjuvant Nanoemulsion" ;
    rdfs:seeAlso "PMID: 17502384" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000527
    obo:IAO_0000115 "a type of 'has vaccine antigen' relation that is specifically for vaccine protective antigen component" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has vaccine protective antigen" ;
    rdfs:subPropertyOf obo:VO_0000524 .

obo:VO_0000528
    obo:IAO_0000116 "Xref: VIOLIN vaccine ID: 223." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis arabinomannan-protein conjugate" ;
    rdfs:seeAlso "PMID: 12922145" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9986
    ] .

obo:VO_0000529
    obo:IAO_0000115 "a type of 'has vaccine component' relation that is specifically for vaccine adjuvant component" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has vaccine adjuvant" ;
    rdfs:subPropertyOf obo:VO_0000520 .

obo:VO_0000530
    obo:IAO_0000115 "a type of 'has vaccine component' relation that is specifically for vaccine vector component" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has vaccine vector" ;
    rdfs:range obo:VO_0000599 ;
    rdfs:subPropertyOf obo:VO_0000520 .

obo:VO_0000531
    obo:IAO_0000115 "a object property that specifies a relation between a vaccine and a vaccine allergen" ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "has vaccine allergen" ;
    rdfs:subPropertyOf owl:topObjectProperty .

obo:VO_0000532
    obo:IAO_0000115 "a route of administration that is loacted in the hypodermis (subcutaneous tissue) region. " ;
    obo:IAO_0000117 "YL" ;
    dc:creator "YH" ;
    oboInOwl:hasSynonym "S.C." ;
    a owl:Class ;
    rdfs:label "subcutaneous route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0002072
    ] .

obo:VO_0000533
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "subdominant epitope in vaccine" ;
    a owl:Class ;
    rdfs:label "vaccine subdominant epitope" ;
    rdfs:subClassOf obo:VO_0000811 .

obo:VO_0000534
    obo:IAO_0000115 "A vaccine that is composed of a purified protein(s) or other antigenic determinant(s) from a disease-causing organism. A subunit vaccine does not include pathogen nucleic acids. The subunits have less risk of causing adverse reactions." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "subunit vaccine" ;
    rdfs:subClassOf obo:VO_0000001 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ] .

obo:VO_0000535
    obo:IAO_0000116 "Xref: VIOLIN vaccineID: 176." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant S. typhimurium secreting M. tuberculosis ESAT-6" ;
    rdfs:seeAlso "PMID: 11427279" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010919
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000536
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Ag85B and ESAT-6 fusion protein" ;
    rdfs:seeAlso "PMID:" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010919
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000537
    obo:IAO_0000115 "an object property that indicates a secretion of a material (e.g., protein) from a vaccine organism." ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "vaccine organism secretes" .

obo:VO_0000538
    obo:IAO_0000117 "YL, YH", "a 'has vaccine component' relation that is specifically used for vaccine preservative" ;
    a owl:ObjectProperty ;
    rdfs:label "has vaccine preservative" ;
    rdfs:subPropertyOf obo:VO_0000520 .

obo:VO_0000539
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "equine EEV, VEV and WEV encephalomyelitis-influenza vaccine-tetanus toxoid"@en ;
    rdfs:subClassOf obo:VO_0002422, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0000540
    obo:IAO_0000115 "time of survival of live vaccine inside host is a temporal interval during which a live vaccine survives inside a host organism. This entity is related to the process survival of live vaccine inside host." ;
    obo:IAO_0000117 "YH, MC" ;
    a owl:Class ;
    rdfs:label "time of survival of live vaccine inside host" ;
    rdfs:subClassOf obo:BFO_0000038 .

obo:VO_0000541
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "'equine EEV, VEE & WEV encephalomyelitis-tetanus toxoid'"@en ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0002420
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11036
            ]
        )
    ] .

obo:VO_0000542
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "equine EEV, VEV and WEV encephalomyelitis-rhinopneumonitis-influenza vaccine-tetanus toxoid"@en ;
    rdfs:subClassOf obo:VO_0002428, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0000543
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "attenuated M. bovis strain WAg539" ;
    rdfs:seeAlso "PMID: 15784584" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000537 ;
        owl:someValuesFrom obo:VO_0010951
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000544
    obo:IAO_0000115 "a vaccinee that is a human being" ;
    a owl:Class ;
    rdfs:label "human vaccinee" ;
    rdfs:subClassOf obo:VO_0001374, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000544
    ] .

obo:VO_0000545
    obo:IAO_0000115 "a population of human beings who are vaccinated." ;
    a owl:Class ;
    rdfs:label "human vaccinee population" ;
    rdfs:subClassOf obo:BFO_0000040, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000544
    ] .

obo:VO_0000546
    obo:IAO_0000115 "a population group that are vaccinated with a specific vaccine" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "vaccinee group" ;
    a owl:Class ;
    rdfs:label "vaccinee population"@en ;
    rdfs:subClassOf obo:OBI_0000181 .

obo:VO_0000547
    a owl:ObjectProperty ;
    rdfs:comment "an object property that specifies a relation between a vaccine and a vaccinate route" ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "vaccinated in route" ;
    rdfs:range obo:VO_0000574 .

obo:VO_0000548
    a owl:Class ;
    rdfs:label "human vaccinee population at age 2-17 years old" ;
    rdfs:subClassOf obo:VO_0000545, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000548
    ] .

obo:VO_0000549
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bacterial phenotype" ;
    rdfs:subClassOf obo:PATO_0001018 .

obo:VO_0000550
    obo:IAO_0000115 "A vaccine that is used for treatment for a disease."^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "therapeutic vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000085 ;
        owl:someValuesFrom obo:VO_0000562
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000085 ;
        owl:someValuesFrom obo:VO_0000562
    ] .

obo:VO_0000551
    obo:IAO_0000115 "a licensed vaccine role that is bears in a licensed human vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed veterinary vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000630 .

obo:VO_0000552
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "attenuated M. bovis strain WAg520" ;
    rdfs:seeAlso "PMID: 10225931" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000553
    obo:IAO_0000115 "an object property that specifies a relation between a vaccine and its vaccinee" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "has vaccinee" .

obo:VO_0000554
    a owl:Class ;
    rdfs:label "human vaccinee at age 2-17 years old" ;
    rdfs:subClassOf obo:VO_0000544, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000554
    ] .

obo:VO_0000555
    obo:IAO_0000115 "A titer (or titre) is a measure of concentration. Titer testing employs serial dilution to obtain approximate quantitative information from an analytical procedure that inherently only evaluates as positive or negative. The titer corresponds to the highest dilution factor that still yields a positive reading; for example, positive readings in the first 8 serial twofold dilutions translate into a titer of 1:256." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB:http://en.wikipedia.org/wiki/Titer" ;
    a owl:Class ;
    rdfs:label "titer" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0000556
    obo:IAO_0000115 "a vaccine that is designed to immunize against two or more strains of the same microorganism, or against two or more microorganisms." ;
    obo:IAO_0000117 "NF, YH" ;
    obo:IAO_0000119 "WEB: http://coastalcarolinaresearch.com/?p=679" ;
    a owl:Class ;
    rdfs:label "multivalent vaccine"@en ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0000557
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "attenuated M. bovis strain WAg522" ;
    rdfs:seeAlso "PMID: 10225931" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000558
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant nontypeable H. influenzae protein P6 with AdDP" ;
    rdfs:seeAlso "PMID: 15031801" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000559
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000559
    obo:IAO_0000115 "a synthetic vaccine adjuvant, adamantylamide dipeptide (AdDP) is the desmuramyl analog of MDP." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "AdDP" ;
    obo:IAO_0000119 "PMID: 8375945" ;
    a owl:Class ;
    rdfs:label "adamantylamide dipeptide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0000560
    obo:IAO_0000115 "A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous substance produced within living cells or organisms; man-made substances created by artificial processes are thus excluded. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment """The term was first used by organic chemist Ludwig Brieger (1849–1919).[3]
For a toxic substance not produced within living organisms, \"toxicant\" and \"toxics\" are also sometimes used.[citation needed].
Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their severity, ranging from usually minor and acute (as in a bee sting) to almost immediately deadly (as in botulinum toxin).-- from Wikipedia."""@en ;
    rdfs:label "toxin" ;
    rdfs:subClassOf obo:CHEBI_23367 .

obo:VO_0000561
    obo:IAO_0000115 "A vaccine containing a toxoid, used to protect against toxins produced by certain bacteria. A toxoid (also called inactivated toxin) is a processed toxin that has been treated by chemical means, heat, or irradiation and is no longer capable of causing disease." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "toxoid vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ] .

obo:VO_0000562
    obo:IAO_0000115 "The therapeutic vaccine function is a function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which ameliorates a specific disorder." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "therapeutic vaccine function" ;
    rdfs:subClassOf obo:VO_0000278, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000054 ;
                owl:someValuesFrom obo:VO_0000495
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000054 ;
                owl:someValuesFrom obo:VO_0000498
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000054 ;
        owl:someValuesFrom obo:VO_0000002
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000054 ;
        owl:someValuesFrom obo:VO_0000497
    ] .

obo:VO_0000563
    obo:IAO_0000115 "a combination vaccine that is used against both bacterial and viral infections." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bacterial and viral combination vaccine" ;
    rdfs:subClassOf obo:VO_0000641, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_10239
                obo:NCBITaxon_2
            )
        ]
    ] .

obo:VO_0000564
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis secA2 mutant" ;
    rdfs:seeAlso "PMID: 17671656" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000799 ;
        owl:someValuesFrom obo:VO_0010950
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000565
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "rBCG-Ag85A[Tokyo]" ;
    rdfs:seeAlso "PMID: 17720625" ;
    rdfs:subClassOf obo:VO_0003130, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010936
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000566
    obo:IAO_0000115 "a bacterial vaccine against Vibrio infection" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Vibrio" ;
    a owl:Class ;
    rdfs:label "Vibrio vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_662
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_662
    ] .

obo:VO_0000567
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine Rv1806-1807" ;
    rdfs:seeAlso "PMID: 16520093" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000568
    obo:IAO_0000115 "A vaccine that protects against Campylobacter bacterial infectioni." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Campylobacter vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_194
    ] .

obo:VO_0000569
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced up-regulated gene expression" ;
    rdfs:subClassOf obo:VO_0000286 .

obo:VO_0000570
    dc:creator "YL" ;
    oboInOwl:hasURI "http://www.petwellness.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Novartis Animal Health US, Inc." .

obo:VO_0000571
    obo:IAO_0000115 "a viral vaccine vector that uses an AAV virus as the vector." ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "Adeno-associated virus vector" ;
    obo:IAO_0000119 "PMID: 24702846; PMID: 24568220; PMID: 24660751; PMID: 24849042; PMID: 24742767; PMID: 24827459" ;
    a owl:Class ;
    rdfs:label "AAV vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 272636" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0000572
    obo:IAO_0000115 "vaccination protocol is the protocol of a vaccination procedure." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "vaccination schedule" ;
    a owl:Class ;
    rdfs:label "vaccination protocol" ;
    rdfs:subClassOf obo:OBI_0000272, [
        a owl:Restriction ;
        owl:onProperty obo:IAO_0000136 ;
        owl:someValuesFrom obo:VO_0000002
    ] .

obo:VO_0000573
    obo:IAO_0000115 "A vaccine that protects against Chlamydia bacterial infection." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Chlamydia vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_810
    ] .

obo:VO_0000574
    obo:IAO_0000115 "a path that is located in gross anatomical part of an organism (e.g., human) and is used for administering a vaccine, a drug, fluid, poison, or other substance into the body. " ;
    obo:IAO_0000116 "CDISC has a codelist: Rout of Administration. Desription from CDISC: The course by which a substance was administered in order to reach the site of action in the body. CDISC_SDTM_Route_of_Administration_Terminology" ;
    obo:IAO_0000117 "YH,YL" ;
    obo:IAO_0000119 "http://en.wikipedia.org/wiki/Route_of_administration" ;
    a owl:Class ;
    rdfs:label "route of administration" ;
    rdfs:seeAlso "http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38114", "http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66729" ;
    rdfs:subClassOf obo:BFO_0000029, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0001062
    ] .

obo:VO_0000575
    obo:IAO_0000115 "vaccine candidate is a processed material that is designed to prevent or ameliorate a disorder in a target organism by modulating adaptive immune responses in that organism by administrating the vaccine." ;
    obo:IAO_0000116 "During our call, we decided not to say vaccine candidate is an output of vaccine preparation, which may be reserved for vaccine alone. -- Aug 4, 2009." ;
    obo:IAO_0000117 "YH, AR, BP, LC, MC, and ZX" ;
    a owl:Class ;
    rdfs:label "vaccine candidate" ;
    rdfs:subClassOf obo:OBI_0000047, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000441
    ] .

obo:VO_0000576
    obo:IAO_0000115 "vaccine preservative that has thimerosal as part." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "thimerosal vaccine preservative" ;
    rdfs:subClassOf obo:VO_0000851, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_9546
    ] .

obo:VO_0000577
    obo:IAO_0000117 "Peptide vaccine is a subunit vaccine that uses small peptide(s) as immunoepitopes.", "YH" ;
    a owl:Class ;
    rdfs:label "peptide vaccine" ;
    rdfs:subClassOf obo:VO_0000534 .

obo:VO_0000578
    obo:IAO_0000115 "H1N1 Influenza vaccine is an Influenza virus vaccine that is used to vaccinate against H1N1 Influenza subtype vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "H1N1 Influenza vaccine" ;
    rdfs:subClassOf obo:VO_0000642 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000642
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_114727
            ]
        )
    ] .

obo:VO_0000579
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Haemophilus somnus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Haemophilus somnus vaccine" ;
    rdfs:subClassOf obo:VO_0000661, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ] .

obo:VO_0000580
    obo:IAO_0000115 "a vaccine component that is chemical substance added to vaccine and enhance and direct immune response to protective antigen. Many of vaccine adjuvants cause a range of serious side-effects." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine adjuvant" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000147
            ]
        )
    ] .

obo:VO_0000581
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "H. influenzae gene" ;
    rdfs:subClassOf obo:OGG_2000000002 .

obo:VO_0000582
    obo:IAO_0000115 "A vaccine regulatory process that is for vaccine producer to apply for vaccine license." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine license application" ;
    rdfs:subClassOf obo:VO_0000683 .

obo:VO_0000583
    obo:IAO_0000116 "Encodes for protein P4" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "nontypeable H. influenzae gene hel (encoding P4)" ;
    rdfs:subClassOf obo:VO_0000581, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0000584
    obo:IAO_0000116 "An assay that is used to detect the immune response of a host to vaccination of a vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "immune response detection assay" ;
    rdfs:subClassOf obo:OBI_0000070 .

obo:VO_0000585
    obo:IAO_0000115 "immunization objective is the specification of an objective to achieve immunization." ;
    obo:IAO_0000117 "YH, XZ" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Immunization" ;
    a owl:Class ;
    rdfs:label "immunization objective" ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:VO_0000586
    obo:IAO_0000115 "a multivalent vaccine that is designed to immunize against at least one bacterial disease and one viral disease." ;
    obo:IAO_0000117 "NF, YH" ;
    a owl:Class ;
    rdfs:label "multivalent vaccine against bacterial and viral diseases"@en ;
    rdfs:subClassOf obo:VO_0000556 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10239
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_2
            ]
        )
    ] .

obo:VO_0000587
    obo:IAO_0000115 "a bacterial vaccine against infection of Bordetella bacterial infection" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Bordetella" ;
    a owl:Class ;
    rdfs:label "Bordetella vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_517
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000165
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_517
            ]
        )
    ] .

obo:VO_0000588
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis phoP mutant SO2" ;
    rdfs:seeAlso "PMID: 16564606", "PMID: 17084814" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000589
    obo:IAO_0000115 "A bacterial vaccine that is used to protect against Aeromonas bacterial infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Aeromonas vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_642
    ] .

obo:VO_0000590
    obo:IAO_0000115 "vaccine preparation is a manufacturing process to produce a vaccine." ;
    obo:IAO_0000117 "YH, BP" ;
    obo:IAO_0000118 "vaccine generation", "vaccine production"^^xsd:string ;
    a owl:Class ;
    rdfs:label "vaccine preparation" ;
    rdfs:subClassOf obo:OBI_0000011, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000055 ;
        owl:someValuesFrom [
            a owl:Restriction ;
            owl:onProperty obo:RO_0000059 ;
            owl:someValuesFrom obo:VO_0001479
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000001
    ] .

obo:VO_0000591
    obo:IAO_0000116 "An assay that is used to detect if a vaccine protects a host against infection of virulent pathogen after vaccine immunization." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "vaccine challenge experiment" ;
    a owl:Class ;
    rdfs:label "vaccine protection assay" ;
    rdfs:subClassOf obo:OBI_0000070, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:OBI_0000712
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000002
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001209
    ] .

obo:VO_0000592
    obo:IAO_0000115 "A bacterial vaccine that protects against Mycobacterium bacterial infection." ;
    obo:IAO_0000117 "YH, RR" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Mycobacterium" ;
    a owl:Class ;
    rdfs:label "Mycobacterium vaccine" ;
    rdfs:subClassOf obo:VO_0000165 .

obo:VO_0000593
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine specific T cell cytokine production" ;
    rdfs:subClassOf obo:VO_0000106 .

obo:VO_0000594
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine specific T cell mediated cytotoxicity" ;
    rdfs:subClassOf obo:VO_0000106 .

obo:VO_0000595
    obo:IAO_0000115 "vaccine dose is a dose of vaccine specified by the vaccine manufacturer, distributor, or a regulatory agent." ;
    obo:IAO_0000117 "YH, MC" ;
    a owl:Class ;
    rdfs:label "vaccine dose" ;
    rdfs:subClassOf obo:OBI_0000984 .

obo:VO_0000596
    obo:IAO_0000115 "A processual entity by which a vaccine is tested clinically for safety and effectiveness. Clinical trials are conducted in phases. Classically, clinical trials unfold in three phases in order to gather data and information about a vaccine and its performance. This will form the basis of a dossier submitted to regulatory authorities by way of an application for licensure. After a vaccine is licensed and is being used by large numbers of people, a Phase IV study may or may not be taken for vaccine clinical evaluation." ;
    obo:IAO_0000116 """Most vaccines against a pathogen (e.g., HIV) are not tested by vaccinating people and then deliberately exposing them to virulent pathogen (e.g., HIV). This strategy is never for a vaccine against a disease as serious as HIV.
The best way to determine if a vaccine is effective is to test it in a randomized, controlled, double-blind clinical trial. This type of trial is often referred to as the gold standard in medical research and provides the strongest evidence for the efficacy of a vaccine.""" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine clinical trial" ;
    rdfs:subClassOf obo:OBI_0000011, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:OBI_0000725
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:VO_0000001
    ] .

obo:VO_0000597
    a owl:Class ;
    rdfs:label "obsolete class"@en ;
    rdfs:subClassOf obo:BFO_0000001 .

obo:VO_0000598
    obo:IAO_0000115 "A vaccine that uses whole organism as its component" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://onlinelibrary.wiley.com/doi/10.1038/npg.els.0000491/full" ;
    a owl:Class ;
    rdfs:label "whole organism vaccine" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000504
    ] .

obo:VO_0000599
    obo:IAO_0000116 "a vaccine component that uses a microbe (e.g., bacterium, virus, and parasitic organism) as a vector that is inserted with the DNA(s) of a heterologous protective antigen(s) to generate a \"recombinant vector vaccine\". The microorganism used as a vector generally has a stable non or low pathogenic phenotype for the species the vaccine is intended for. "^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "recombinant vector" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Vaccine", "WEB: http://www.biosafety.be/GT/Regulatory/Veterinary_vaccines/EMEA_000404en.pdf", "WEB: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003856.pdf" ;
    a owl:Class ;
    rdfs:label "recombinant vaccine vector" ;
    rdfs:subClassOf obo:VO_0000179 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000145
            ]
        )
    ] .

obo:VO_0000600
    obo:IAO_0000115 "an orthopoxvirus vaccine vector that uses vaccinia virus as the vector" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccinia virus vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10245" ;
    rdfs:subClassOf obo:VO_0001146 .

obo:VO_0000601
    obo:IAO_0000115 "A bacterial vaccine that protects against Yersinia bacterial infection." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Yersinia vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_629
    ] .

obo:VO_0000602
    obo:IAO_0000115 "A bacterial vaccine that is used to protect against Edwardsiella bacterial infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Edwardsiella vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_635
    ] .

obo:VO_0000603
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "BCG mutant secreting listeriolysin" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0000604
    obo:IAO_0000115 "a bacterial vaccine against Mycoplasma bacterial infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Mycoplasma vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2093
    ] .

obo:VO_0000605
    obo:IAO_0000115 "a Canada licensed vaccine role that indicates the vaccine is used for human" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Canada licensed human vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000864 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000489
            obo:VO_0000864
        )
    ] .

obo:VO_0000606
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "delta ureC hly+ rBCG" ;
    rdfs:seeAlso "PMID: 16110326" ;
    rdfs:subClassOf obo:VO_0003130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0000607
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Intercell Biomedical" .

obo:VO_0000608
    obo:IAO_0000117 "YH", "an 'expresses' relation that specifies a relation between a DNA vaccine and a  protein antigen to be expressed by the DNA vaccine. " ;
    a owl:ObjectProperty ;
    rdfs:label "DNA vaccine expresses protein antigen"@en ;
    rdfs:subPropertyOf obo:RO_0002292 .

obo:VO_0000609
    obo:IAO_0000115 "A vaccine that targets against a viral disease."^^xsd:string ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "viral vaccine" ;
    rdfs:seeAlso "MeSH: D014765" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10239
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10239
    ] .

obo:VO_0000610
    obo:IAO_0000115 "a vaccine vector that uses a virus as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "viral vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10239" ;
    rdfs:subClassOf obo:VO_0000599 .

obo:VO_0000611
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Haemophilus parasuis infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Haemophilus parasuis vaccine" ;
    rdfs:subClassOf obo:VO_0000661, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_738
    ] .

obo:VO_0000612
    obo:IAO_0000115 "a virulence of vaccine that shows a virulent pheontype of the organism as the major component of a vaccine. The virulent phenotype means that an vaccine organism is virulent and is able to cause a pathogenic phenotype in a host organism." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine organism virulent" ;
    rdfs:subClassOf obo:PATO_0002146 .

obo:VO_0000613
    obo:IAO_0000112 "‘M’ (intended to refer to a male biological sex), ‘Male’, ‘Man’, ‘1’ (intended to refer to a male biological sex)" ;
    obo:IAO_0000115 "A biological sex datum that represents the biological sex of an animal (including human) as being male." ;
    obo:IAO_0000117 "Paul Fabry, Oliver He" ;
    a owl:Class ;
    rdfs:label "male biological sex datum"@en ;
    rdfs:subClassOf obo:VO_0001194 .

obo:VO_0000614
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Nontypeable H. influenzae protein P6 with cholera toxin" ;
    rdfs:seeAlso "PMID: 15297063" ;
    rdfs:subClassOf obo:VO_0000471, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10114
    ] .

obo:VO_0000615
    obo:IAO_0000117 "YH", "a role that inheres in a prepared material entity that is designed to induce protection or treatment for a disease or infection. " ;
    a owl:Class ;
    rdfs:label "vaccine role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0000616
    obo:IAO_0000115 "Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "animal model of vaccine research" ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0000617
    obo:IAO_0000117 "YH", "a role that inheres in a material entity that becomes an ingredient of a vaccine. " ;
    a owl:Class ;
    rdfs:label "vaccine component role"@en ;
    rdfs:subClassOf obo:BFO_0000023, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom [
            a owl:Restriction ;
            owl:onProperty obo:BFO_0000050 ;
            owl:someValuesFrom obo:VO_0000001
        ]
    ] .

obo:VO_0000618
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine antigen role"@en ;
    rdfs:subClassOf obo:VO_0000617 .

obo:VO_0000619
    a owl:Class ;
    rdfs:label "E. coli live attenuated vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000620
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Pasteurella multocida infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pasteurella multocida vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0000621
    obo:IAO_0000115 "Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research in the laboratory." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "laboratory animal model of vaccine research" ;
    rdfs:subClassOf obo:VO_0000616 .

obo:VO_0000622
    obo:IAO_0000115 "a vaccine antigen role that inheres in a vaccine antigen which is capable of inducing protective immunity. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine protective antigen role"@en ;
    rdfs:subClassOf obo:VO_0000618 .

obo:VO_0000623
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a DNA vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000624
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a subunit vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "subunit vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000625
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a conjugate vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "conjugate vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000626
    obo:IAO_0000115 "Survival assessment is an assay that measures the occurence of death events in one or more organisms that are monitored over time." ;
    obo:IAO_0000116 "Need to point out more specifically that survival / death is measured." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "survival assessment" ;
    rdfs:subClassOf obo:OBI_0000011, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom obo:OBI_0100026
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:IAO_0000109
                [
                    a owl:Restriction ;
                    owl:onProperty obo:IAO_0000136 ;
                    owl:someValuesFrom obo:OBI_0100026
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000417 ;
        owl:someValuesFrom obo:OBI_0000441
    ] .

obo:VO_0000627
    obo:IAO_0000115 "A vaccine used to prevent infection by Haemophilus influenzae type b (Hib) bacteria. The vaccine works by causing your body to produce its own protection (antibodies) against the disease." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Hib polysaccharide vaccine" ;
    obo:IAO_0000119 "https://www.mayoclinic.org/drugs-supplements/haemophilus-b-polysaccharide-vaccine-intramuscular-route-injection-route/description/drg-20064142" ;
    a owl:Class ;
    rdfs:label "H. influenzae Type b capsular polysaccharide vaccine" ;
    rdfs:seeAlso "PMID: 335348", "PMID: 6387614" ;
    rdfs:subClassOf obo:VO_0000662, obo:VO_0001255, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000628
    obo:IAO_0000115 "An E. coli vaccine that uses subunit antigen type." ;
    a owl:Class ;
    rdfs:label "E. coli subunit vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000629
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis recombinant vaccine using PA domain 4" ;
    rdfs:seeAlso "PMID: 11854261", "PMID: 15935874" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010872
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000630
    obo:IAO_0000115 "licensed vaccine role is a regulation-assigned role that indicates that a vaccine obtains official approval for commercial production and selling on the market." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed vaccine role" ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000631
    obo:IAO_0000115 "vaccine in clinical trial role is a regulation-assigned role that inheres in a vaccine that is currently in clinical trial." ;
    obo:IAO_0000116 "In medical research, clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine in clinical trial role" ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000632
    obo:IAO_0000115 "Vaccine induced immue response mediated hrough a body fluid" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "vaccine-induced humoral immune response" ;
    rdfs:subClassOf obo:VO_0000287 .

obo:VO_0000633
    obo:IAO_0000115 "A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the p39 gene deletion." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. melitensis Rev. 1 P39 deletion mutant" ;
    obo:IAO_0000119 "PMID: 9784574" ;
    a owl:Class ;
    rdfs:label "B. melitensis Rev. 1 with P39 deletion" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000634
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "intravenous vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000416
    ] .

obo:VO_0000635
    obo:IAO_0000115 "a licensed vaccine with license for human use." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed human vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000489
    ] .

obo:VO_0000636
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a recombinant vector vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant vector vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000637
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Flavobacterium columnare infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Flavobacterium columnare vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_996
    ] .

obo:VO_0000638
    obo:IAO_0000112 "\"A vaccinates B\" means that the vaccine A is used for vaccinating the host B (e.g., human)." ;
    obo:IAO_0000115 "A relationship between a vaccine instance and an organism type such that if the vaccine instance is given to an instance of the organism by the process vaccination, then it changes the organism's disposition to have an immune response against a disease." ;
    obo:IAO_0000117 "YH, AR, ZX, MC" ;
    a owl:ObjectProperty ;
    rdfs:label "vaccinates" ;
    rdfs:subPropertyOf oboInOwl:ObsoleteProperty .

obo:VO_0000639
    obo:IAO_0000115 "A bacterial vaccine that protects against infection with Clostridium spp." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Clostridium" ;
    a owl:Class ;
    rdfs:label "Clostridium vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1485
    ] .

obo:VO_0000640
    obo:IAO_0000115 "a Clostridium vaccine that protects against infection with Clostridium tetani that causes tenanus." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000118 "Tetanus toxoid vaccine", "tetanus vaccine" ;
    obo:IAO_0000119 "https://vaccine-safety-training.org/tetanus-vaccine-example.html" ;
    a owl:Class ;
    rdfs:label "Clostridium tetani vaccine" ;
    rdfs:subClassOf obo:VO_0000639, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1513
    ] .

obo:VO_0000641
    obo:IAO_0000115 """Combination vaccine is a vaccine that induces protection against multiple infectious diseases or several different serotypes of the same organism. The anitgens contained in combination vaccines are either formulated together by the manufacturer or physically mixed by a health care provider just prior to administration. Both approaches require licensure.
Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008.  p1624.""" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "combo vaccine" ;
    a owl:Class ;
    rdfs:label "combination vaccine" ;
    rdfs:seeAlso "MeSH: D017778" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ;
        owl:onClass obo:OBI_0100026 ;
        owl:onProperty obo:VO_0001243
    ] .

obo:VO_0000642
    obo:IAO_0000115 "A viral vaccine that protects against infection with influenza virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Influenza vaccine" ;
    a owl:Class ;
    rdfs:comment """There is no single 'influenza virus' in NCBI_Taxon. We usually use:
('unidentified influenza virus' or 'Influenzavirus A' or 'Influenzavirus B' or 'Influenzavirus C')
However, even this may not be comprehensive. """ ;
    rdfs:label "Influenza virus vaccine" ;
    rdfs:seeAlso "MeSH: D007252; UMLS_CUI: C0021403; SNOMEDCT: 46233009" ;
    rdfs:subClassOf obo:VO_0000609 .

obo:VO_0000643
    obo:IAO_0000115 "a vaccine with license that is used for cattle." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed cattle vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0000644
    obo:IAO_0000115 "A viral vaccine that protects against infection with Hepatitis B virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Hepatitis_B_vaccine" ;
    a owl:Class ;
    rdfs:label "Hepatitis B virus vaccine" ;
    rdfs:seeAlso "MeSH: D017325" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10407
            ]
        )
    ] .

obo:VO_0000645
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed fish vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_7898
    ] .

obo:VO_0000646
    obo:IAO_0000115 "A viral vaccine that protects against infection with Hepatitis A virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis A virus vaccine" ;
    rdfs:seeAlso "MeSH: D022362" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12092
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12092
    ] .

obo:VO_0000647
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed goat vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9925
    ] .

obo:VO_0000648
    obo:IAO_0000115 "A bacteria vaccine that prevents against Yersinia pestis infection that causes plague." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Plague vaccine" ;
    a owl:Class ;
    rdfs:label "Yersinia pestis vaccine" ;
    rdfs:seeAlso "MeSH: D010931; SNOMEDCT: 11866009; UMLS_CUI:C0032066" ;
    rdfs:subClassOf obo:VO_0000601, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0000649
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed dog vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9611
    ] .

obo:VO_0000650
    obo:IAO_0000115 "A viral vaccine that protects against infection with Rabies virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Rabies virus vaccine" ;
    rdfs:seeAlso "MeSH: D011819; SNOMEDCT: 333606008; UMLS_CUI:C0034496" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11292
            ]
        )
    ] .

obo:VO_0000651
    obo:IAO_0000115 "A viral vaccine that protects against infection with Smallpox virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Smallpox virus vaccine" ;
    rdfs:seeAlso "MeSH: D012900" ;
    rdfs:subClassOf obo:VO_0000512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0000652
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed cat vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9682
    ] .

obo:VO_0000653
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed ferret vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9669
    ] .

obo:VO_0000654
    obo:IAO_0000115 "A viral vaccine that protects against infection with Measles virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Measles vaccine" ;
    a owl:Class ;
    rdfs:label "Measles virus vaccine" ;
    rdfs:seeAlso "MeSH: D008458" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11234
    ] .

obo:VO_0000655
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed deer vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9850
    ] .

obo:VO_0000656
    obo:IAO_0000115 "A viral vaccine that protects against infection with Mumps virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Mumps virus vaccine" ;
    rdfs:seeAlso "MeSH: D009108" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11161
            ]
        )
    ] .

obo:VO_0000657
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "licensed bird vaccine" ;
    rdfs:subClassOf obo:VO_0000363, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8825
    ] .

obo:VO_0000658
    obo:IAO_0000115 "A viral vaccine that protects against infection with Rotavirus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Rotavirus vaccine" ;
    rdfs:seeAlso "MeSH: D022243; UMLS_CUI: C0597418; SNOMEDCT: 116077000" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10912
            ]
        )
    ] .

obo:VO_0000659
    obo:IAO_0000116 "In most cases HibTITER was administered concomitantly with other vaccines including DTP, DTaP, hepatitis B vaccine, IPV, OPV, pneumococcal 7-valent conjugate vaccine, MMR, and/or meningococcal group C conjugate vaccine (not licensed in the US)." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "HIBTITER" ;
    rdfs:seeAlso "PMID:", "PMID: 2057256", "PMID: 9353019" ;
    rdfs:subClassOf obo:VO_0000662, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000660
    obo:IAO_0000116 "Ref: http://www.rxlist.com/prohibit-drug.htm" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "ProHIBiT" ;
    rdfs:seeAlso "PMID: 2057256" ;
    rdfs:subClassOf obo:VO_0000662, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000661
    obo:IAO_0000115 "A bacterial vaccine that protects against infection with Haemophilus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Haemophilus" ;
    a owl:Class ;
    rdfs:label "Haemophilus vaccine" ;
    rdfs:seeAlso "MeSH: D018073" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000165
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_724
            ]
        )
    ] .

obo:VO_0000662
    obo:IAO_0000115 "A vaccine that protects against Haemophilus influenzae type b infection." ;
    obo:IAO_0000117 "Oliver He, Hector Guzman-Orozco" ;
    obo:IAO_0000118 "Haemophilus b vaccine" ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae serotype b vaccine" ;
    rdfs:subClassOf obo:VO_0012185 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0012185
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:VO_0000741
            ]
        )
    ] .

obo:VO_0000663
    obo:IAO_0000116 "A live attenuated Shigella flexneri 2a vaccine that carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding aerobactin). PMID: 10377124." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "SC602" ;
    rdfs:seeAlso "PMID: 10377124" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000664
    obo:IAO_0000115 "A viral vaccine that protects against infection with Poliovirus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Poliovirus vaccine" ;
    rdfs:seeAlso "MeSH: D023321" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:NCBITaxon_12080
                obo:NCBITaxon_12083
                obo:NCBITaxon_12086
            )
        ]
    ] .

obo:VO_0000665
    obo:IAO_0000115 "A viral vaccine that protects against infection with Japanese encephalitis virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Japanese encephalitis vaccine" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus vaccine" ;
    rdfs:seeAlso "MeSH: D022321" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11072
    ] .

obo:VO_0000666
    obo:IAO_0000116 "CVD 1208 is derived from wild type Shigella flexneri 2a strain 2457T and has defined deletions in four genes: (1) the guaBA chromosomal operon that encodes two enzymes (inositol 5'-monophosphate dehydrogenase and guanosine 5'synthase) essential for de novo purine biosynthesis; (2) set, a locus in a chromosomal pathogenicity island that encodes Shigella enterotoxin (ShET); (3) Pic, an autotransporter mucinase encoded on the opposite strand from set; and (4) sen, an invasiveness plasmid gene encoding ShET. PMID: 15499528" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "CVD 1208" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001014
    ] .

obo:VO_0000667
    obo:IAO_0000115 "a vaccine against human papillomavirus infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human papillomavirus vaccine" ;
    rdfs:seeAlso "UMLS_CUI: C1512511; SNOMEDCT: 424519000" ;
    rdfs:subClassOf obo:VO_0000748 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0000668
    obo:IAO_0000116 "CVD 1208S is the same thing as CVD 1208, but CVD 1208S was prepared using animal-free media. PMID: 17938573." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "CVD 1208S" ;
    rdfs:seeAlso "PMID: 17938573" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000669
    obo:IAO_0000115 "a Herpesvirus vaccine that is used against Varicella-zoster virus infection." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000118 "Varicella vaccine", "chickenpox and shingles virus vaccine" ;
    a owl:Class ;
    rdfs:label "Varicella-zoster virus vaccine" ;
    rdfs:seeAlso "UMLS_CUI: C0078048; SNOMEDCT: 108729007" ;
    rdfs:subClassOf obo:VO_0000727, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10335
    ] .

obo:VO_0000670
    obo:IAO_0000116 "This vaccine is an aro-D mutant derivative of EcSf2a-1. PMID: 1587589." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "EcSf2a-2" ;
    rdfs:seeAlso "PMID: 1587589" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000671
    obo:IAO_0000115 "a Salmonella vaccine against typhoid fever (or called typoid), caused by Salmonella enterica enterica, serovar Typhi. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "typhoid vaccine" ;
    a owl:Class ;
    rdfs:label "Salmonella typhi vaccine" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_90370
    ] .

obo:VO_0000672
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "heat-killed virulent Shigella flexneri 2a" ;
    rdfs:seeAlso "PMID: 10102148" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9986
    ] .

obo:VO_0000673
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Shigella Sfl 124 vaccine" ;
    rdfs:seeAlso "PMID: 1937767" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000674
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Recombinant SFL124-27 expressing S. dysenteriae type 1 O antigen" ;
    rdfs:seeAlso "PMID: 9169740" ;
    rdfs:subClassOf obo:VO_0000681, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000675
    obo:IAO_0000115 "a Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "pneumococcal vaccine" ;
    obo:IAO_0000119 "WEB: http://www.who.int/vaccines/en/pneumococcus.shtml" ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae vaccine" ;
    rdfs:subClassOf obo:VO_0000772, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0000676
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "S. dysenteriae 1 strain WRSd1" ;
    rdfs:seeAlso "PMID: 12010984" ;
    rdfs:subClassOf obo:VO_0000681, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000677
    obo:IAO_0000115 "A  live attenuated Shigella flexneri 2a vaccine with specific deletion mutations in virG, sen, set, and guaBA." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "S. flexneri 2a strain CVD 1207" ;
    rdfs:seeAlso "PMID: 10678904" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001014
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000678
    obo:IAO_0000115 "A stable attenuated Shigella sonnei strain with virG mutation. PMID: 9712824." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "S. sonnei strain WRSS1" ;
    rdfs:seeAlso "PMID: 11895966", "PMID: 9712824" ;
    rdfs:subClassOf obo:VO_0000679, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000679
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Shigella sonnei vaccine" ;
    rdfs:subClassOf obo:VO_0000769, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_624
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_624
    ] .

obo:VO_0000680
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Shigella flexneri vaccine" ;
    rdfs:subClassOf obo:VO_0000769, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_623
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_623
    ] .

obo:VO_0000681
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Shigella dysenteriae vaccine" ;
    rdfs:subClassOf obo:VO_0000769 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_622
    ] .

obo:VO_0000682
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "S. flexneri 2a LPS vaccine complexed with N. meningitidis proteosomes" ;
    rdfs:seeAlso "PMID: 8500877" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000683
    obo:IAO_0000115 "A processual entity that regulates vaccine-related processes, such as vaccine trial, vaccine license application." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine regulation" ;
    rdfs:subClassOf obo:OBI_0000011 .

obo:VO_0000684
    obo:IAO_0000115 "A processual entity of transporting vaccine from one place to another place." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine transportation" ;
    rdfs:subClassOf obo:OBI_0000011 .

obo:VO_0000685
    obo:IAO_0000115 "a recombinant vector vaccine role that inheres in a bacterium that carries a vaccine antigen for development of a particular vaccine " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant bacterial vector vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000636 .

obo:VO_0000686
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.acambis.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Acambis, Inc" .

obo:VO_0000687
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.crucell.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Berna Biotech, Ltd" .

obo:VO_0000688
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.bioport.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "BioPort Corp" .

obo:VO_0000689
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.csl.com.au/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "CSL Limited" .

obo:VO_0000690
    obo:IAO_0000115 "A British multinational pharmaceutical company headquartered in Brentford, England" ;
    obo:IAO_0000117 "Oliver He, Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/GlaxoSmithKline" ;
    oboInOwl:hasURI "https://www.gsk.com/en-gb/home/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "GlaxoSmithKline plc"@en .

obo:VO_0000691
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.greerlabs.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Greer Laboratories Inc" .

obo:VO_0000692
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.ctidirectory.com/search/company.cfm?company=129584" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "ID Biomedical Corp of Quebec" .

obo:VO_0000693
    obo:IAO_0000117 "YH" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Massachusetts Public Health Biologic Lab" .

obo:VO_0000694
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.medimmune.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "MedImmune Vaccines, Inc" .

obo:VO_0000695
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Merck Sharp & Dohme Corp." ;
    oboInOwl:hasURI "http://www.merck.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Merck & Co., Inc." .

obo:VO_0000696
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.novartis.com/about-novartis/our-businesses/vaccines-diagnostic.shtml" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Novartis Vaccines and Diagnostics" .

obo:VO_0000697
    obo:IAO_0000116 """100 Rodolphe Street
Building 1300
Durham, NC 27712""" ;
    obo:IAO_0000117 "YH" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Organon Teknika Corp LLC" .

obo:VO_0000698
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://read.jst.go.jp/public/cs_kkn_004EventAction.do?action5=event&lang_act5=E&kcd1_act5=9535000000&judge_act5=2" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Research Foundation for Microbial Diseases of Osaka University" .

obo:VO_0000699
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.sanofipasteur.com" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Sanofi Pasteur Limited" .

obo:VO_0000700
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasExactSynonym "Aventis Pasteur Inc." ;
    oboInOwl:hasURI "http://www.sanofipasteur.us" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Sanofi Pasteur, Inc" .

obo:VO_0000701
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.wyeth.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Wyeth Pharmaceuticals Inc" .

obo:VO_0000702
    obo:IAO_0000115 "a recombinant vector vaccine role that inheres in a virus that carries a vaccine antigen for development of a particular vaccine " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant viral vector vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000636 .

obo:VO_0000703
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.sanofipasteur.co.za/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Sanofi Pasteur, SA" .

obo:VO_0000704
    obo:IAO_0000115 "a vaccine residual that is from antibiotics used during the manufacture process." ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "antibiotics vaccine residual" ;
    rdfs:subClassOf obo:VO_0000854 .

obo:VO_0000705
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine specific antibody test" ;
    rdfs:subClassOf obo:VO_0000584 .

obo:VO_0000706
    obo:IAO_0000115 "A vaccine regulation process for vaccine clinical trials." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine trial regulation" ;
    rdfs:subClassOf obo:VO_0000683 .

obo:VO_0000707
    obo:IAO_0000115 "A vaccination process that occurs at the first time to a host organization in a specified period." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "prime vaccination" ;
    a owl:Class ;
    rdfs:label "primary vaccination" ;
    rdfs:subClassOf obo:VO_0000002 .

obo:VO_0000708
    obo:IAO_0000116 "A vaccination process that occurs after the primer vaccination with a purpose to boost host immune response to vaccine antigen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "boost vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000062 ;
        owl:someValuesFrom obo:VO_0000707
    ] .

obo:VO_0000709
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis vaccine" ;
    rdfs:subClassOf obo:VO_0000025 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000025
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_29459
            ]
        )
    ] .

obo:VO_0000710
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Brucella melitensis Rev 1", "Brucella melitensis Rev. 1" ;
    a owl:Class ;
    rdfs:label "B. melitensis strain Rev. 1" ;
    rdfs:seeAlso "PMID: 13416171" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000799 ;
        owl:someValuesFrom obo:VO_0010963
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9925
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9935
    ] .

obo:VO_0000711
    obo:IAO_0000115 "has_vaccine_allegen is a relation that specifies an allegen to a vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:label "has_vaccine_allergen" ;
    rdfs:subPropertyOf oboInOwl:ObsoleteProperty .

obo:VO_0000712
    obo:IAO_0000115 "a viral vaccine that is inactivated" ;
    obo:IAO_0000118 "killed viral vaccine" ;
    a owl:Class ;
    rdfs:label "inactivated viral vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0000211
            ]
        )
    ] .

obo:VO_0000713
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine allergen disposition" ;
    rdfs:subClassOf obo:BFO_0000016 .

obo:VO_0000714
    obo:IAO_0000115 "a licensed human vaccine that is licensed in Canada" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Canada licensed human vaccine" ;
    rdfs:subClassOf obo:VO_0000635 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000605
    ] .

obo:VO_0000715
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a DNA vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of DNA vaccine"@en ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000032
    ] .

obo:VO_0000716
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a conjugate vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000195
    ] .

obo:VO_0000717
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a subunit vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "subunit vaccine preparation" ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000534
    ] .

obo:VO_0000718
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a live attenuated vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated vaccine preparation" ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000367
    ] .

obo:VO_0000719
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a RNA vaccine"@en ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of RNA vaccine"@en ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000186
    ] .

obo:VO_0000720
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus strain RB51SOD" ;
    a owl:Class ;
    rdfs:label "Brucella abortus strain RB51SOD" ;
    rdfs:seeAlso "PMID: 10816475" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000208
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0000154
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000721
    obo:IAO_0000115 "a Brucella vaccine against infection wtih B. suis" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella suis vaccine" ;
    rdfs:subClassOf obo:VO_0000025 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000025
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_29461
            ]
        )
    ] .

obo:VO_0000722
    obo:IAO_0000115 "An orally administrable brucellosis vaccine that was was developed in China. It is effective for oral vaccination of sheep, goats, cattle and pigsPMID: 3541425." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Brucella suis S2" ;
    a owl:Class ;
    rdfs:label "Brucella suis strain 2" ;
    rdfs:subClassOf obo:VO_0001136, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ] .

obo:VO_0000723
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus strain 45/20" ;
    a owl:Class ;
    rdfs:label "Brucella abortus strain 45/20" ;
    rdfs:seeAlso "PMID: 8236802" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ] .

obo:VO_0000724
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "cytomegalovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000727 .

obo:VO_0000725
    obo:IAO_0000115 "A viral vaccine that protects against infection with Dengue virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Dengue vaccine" ;
    a owl:Class ;
    rdfs:label "Dengue virus vaccine" ;
    rdfs:seeAlso "MeSH: D053059" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_12637
            ]
        )
    ] .

obo:VO_0000726
    obo:IAO_0000115 "A viral vaccine that protects against infection with Ebola virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Ebola vaccine" ;
    a owl:Class ;
    rdfs:label "Ebola virus vaccine" ;
    rdfs:seeAlso "MeSH: D046129" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0000727
    obo:IAO_0000115 "A viral vaccine that protects against infection with Herpesvirus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Herpesvirus vaccine" ;
    rdfs:seeAlso "MeSH: D022283" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10292
    ] .

obo:VO_0000728
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a RNA vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "RNA vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000729
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus vaccine" ;
    rdfs:subClassOf obo:VO_0000727 .

obo:VO_0000730
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Marek disease vaccine" ;
    rdfs:subClassOf obo:VO_0000727 .

obo:VO_0000731
    obo:IAO_0000115 "A Measles-Mumps vaccine that also protects against infection with  Rubella virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "MMR" ;
    a owl:Class ;
    rdfs:comment "MMR is usually live attenuated. " ;
    rdfs:label "Measles-Mumps-Rubella vaccine" ;
    rdfs:subClassOf obo:VO_0000736, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11041
    ] .

obo:VO_0000732
    obo:IAO_0000115 "A Corynebacterium diphtheriae vaccine that also protect against infection with Clostridium tetani." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus vaccine" ;
    rdfs:subClassOf obo:VO_0000735, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1513
    ] .

obo:VO_0000733
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "CVD 1204(pGA1-CS2)" ;
    rdfs:seeAlso "PMID: 11292735" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000734
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "CVD 1204(pGA1-CS3)" ;
    rdfs:seeAlso "PMID: 11292735" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000735
    obo:IAO_0000115 "A bacterial vaccine that protects against infection with Corynebacterium diphtheriae that causes Diphtheria." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "diphtheria vaccine" ;
    a owl:Class ;
    rdfs:label "Corynebacterium diphtheriae vaccine" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1717
    ] .

obo:VO_0000736
    obo:IAO_0000115 "A Measles virus vaccine that also protects against infection with  Mumps virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Measles-Mumps vaccine" ;
    rdfs:subClassOf obo:VO_0000654, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11161
    ] .

obo:VO_0000737
    obo:IAO_0000115 "A Measles-Mumps-Rubella vaccine that also protects against Varicella." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000119 "https://www.cdc.gov/vaccines/hcp/vis/vis-statements/mmrv.html" ;
    a owl:Class ;
    rdfs:label "Measles-Mumps-Rubella-Varicella vaccine" ;
    rdfs:subClassOf obo:VO_0000731, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10335
    ] .

obo:VO_0000738
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "DTP vaccine", "DTaP vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis vaccine" ;
    rdfs:seeAlso "UMLS_CUI: C0012559; SNOMEDCT: 421245007" ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0000739
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Shigella ribosome-based Vaccine (SRB)" ;
    rdfs:seeAlso "PMID: 17507120" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000740
    obo:IAO_0000115 "A malaria vaccine that comprises recombinant Plasmodium falciparum (P. falciparum) blood-stage proteins MSP1, MSP2 and RESA, formulated with the adjuvant Montanide ISA 720. PMID: 14604568." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum vaccine Combination B" ;
    rdfs:seeAlso "PMID: 14604568" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010959
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000741
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae serotype b" ;
    rdfs:subClassOf obo:NCBITaxon_727 .

obo:VO_0000742
    obo:IAO_0000115 "A vaccine that protects against diphtheria, tetanus, pertussis, and poliovirus." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTaP/IPV vaccine", "diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine." ;
    obo:IAO_0000119 "https://www.nhsinform.scot/healthy-living/immunisation/vaccines/the-4-in-1-vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000943, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0000743
    obo:IAO_0000115 "A vaccine used to prevent infections of diphtheria, tetanus (lockjaw), pertussis (whooping cough), hepatitis B, and poliovirus." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTaP/IPV/HepB vaccine" ;
    obo:IAO_0000119 "https://www.hendricks.org/HealthLibrary/default.aspx?sid=1&pTitle=%2CDrug&ContentTypeID=26&ContentID=2783&alpha=D&AdditionalTitle=Diphtheria+Toxoid%2C+Tetanus+Toxoid%2C+Acellular+Pertussis+Vaccine%2C+DTaP%3B+Hepatitis+B+Vaccine%2C+Recombinant%3B+Inactivated+Poliovirus+Vaccine%2C+IPV" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine" ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000145
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0000744
    obo:IAO_0000115 "A vaccine that protects against, Diphtheria, Tetanus, Pertussis (whooping cough), Polio, and Haemophilus influenzae type b." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTaP/IPV/Hib vaccine" ;
    obo:IAO_0000119 "https://www.healthlinkbc.ca/healthlinkbc-files/dtap-ipv-hib-vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine" ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:VO_0000741
    ] .

obo:VO_0000745
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis A&B vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12092
    ] .

obo:VO_0000746
    obo:IAO_0000115 "a viral vaccine against Hepatitis B virus and at the same time against bacterial H. influenzae serotype b." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Haemophilus b and Hepatitis B vaccine" ;
    rdfs:subClassOf obo:VO_0000644 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000644
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:VO_0000741
            ]
        )
    ] .

obo:VO_0000747
    obo:IAO_0000115 "A vaccine that contains DNA and modified vaccinia virus Ankara (MVA) encoding thrombospondin-related adhesion protein (TRAP) with a multiple-epitope string ME (ME-TRAP). This vaccine is used with a prime-boost regime by DNA priming and MVA boosting. PMID: 16988273." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA and MVA encoding ME-TRAP" ;
    rdfs:seeAlso "PMID: 16988273" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000608 ;
        owl:someValuesFrom obo:VO_0010920
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000748
    obo:IAO_0000115 "A viral vaccine that protects against infection with Papillomavirus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Papillomavirus vaccine" ;
    rdfs:seeAlso "MeSH: D053918" ;
    rdfs:subClassOf obo:VO_0000609 .

obo:VO_0000749
    obo:IAO_0000115 "A viral vaccine that protects against infection with Parainfluenza virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "parainfluenza vaccine" ;
    a owl:Class ;
    rdfs:label "Parainfluenza virus vaccine" ;
    rdfs:seeAlso "MeSH: D022241" ;
    rdfs:subClassOf obo:VO_0000609 .

obo:VO_0000750
    obo:IAO_0000115 "A viral vaccine that protects against infection with Pseudorabies virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "pseudorabies vaccine" ;
    a owl:Class ;
    rdfs:label "Pseudorabies virus vaccine" ;
    rdfs:seeAlso "MeSH: D022421" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0000751
    obo:IAO_0000115 "A viral vaccine that prevents against infection with Simian immunodeficiency virus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "SAIDS vaccine" ;
    a owl:Class ;
    rdfs:label "Simian immunodeficiency virus vaccine" ;
    rdfs:seeAlso "MeSH: D018449" ;
    rdfs:subClassOf obo:VO_0000609 .

obo:VO_0000752
    obo:IAO_0000115 "A viral vaccine that protects against West Nile virus infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "West Nile virus vaccine" ;
    rdfs:seeAlso "MeSH: D053060" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11082
            ]
        )
    ] .

obo:VO_0000753
    obo:IAO_0000115 "A viral vaccine that prevents infection with Respiratory syncytial virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Respiratory syncytial virus vaccine" ;
    rdfs:seeAlso "MeSH: D022261" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_12814
            ]
        )
    ] .

obo:VO_0000754
    obo:IAO_0000115 "A vaccine that is used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. It can be a subunit or a gene-deleted vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "marker vaccine" ;
    rdfs:seeAlso "MeSH: D022581" ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0000755
    obo:IAO_0000115 "A vaccine that is edible and derived from an edible plant. The transgenic plant is used as recombinant protein production system. The edible plant tissue functions as an oral vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "edible vaccine" ;
    rdfs:seeAlso "MeSH: D022462" ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000246
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000001
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0000246
            ]
        )
    ] .

obo:VO_0000756
    obo:IAO_0000115 "acellular vaccine is a subunit vaccine that is produced by using only the antigenic part of the disease causing organism. It often requires a \"booster\" every few years to maintain their effectiveness. MeSH term: D20.215.894.860.900." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "acellular vaccine" ;
    rdfs:subClassOf obo:VO_0000534 .

obo:VO_0000757
    obo:IAO_0000115 "A particulate antigen delivery system, ISCOM is a vaccine adjuvant that consists of an assembly of antigens in multimeric form and presents an antigen to induce specific immunologic responses. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines. MeSH term: D20.215.894.860.449." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "ISCOM", "The immunostimulating complex" ;
    a owl:Class ;
    rdfs:label "ISCOM vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001356 .

obo:VO_0000758
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Plasmodium vivax vaccine" ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5855
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5855
    ] .

obo:VO_0000759
    obo:IAO_0000115 "A vaccine that is used to prevent conception." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "antifertility vaccine" ;
    a owl:Class ;
    rdfs:label "contraceptive vaccine" ;
    rdfs:seeAlso "MeSH: D022642" ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0000760
    obo:IAO_0000115 "A vaccine that prevents or treats Alzheimer disease." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Alzheimer vaccine" ;
    rdfs:seeAlso "MeSH: D023582" ;
    rdfs:subClassOf obo:VO_0002813 .

obo:VO_0000761
    obo:IAO_0000115 "Plasmodium vaccine is a vaccine that prevents against Plasmodium species causing malaria. It is made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Plasmodium vaccine", "malarial Vaccine" ;
    a owl:Class ;
    rdfs:label "malaria vaccine" ;
    rdfs:seeAlso "MeSH: D017780" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0000762
    obo:IAO_0000115 "a protozoan vaccine that prevents against infection with Leishmania." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Leishmaniasis vaccine" ;
    a owl:Class ;
    rdfs:label "Leishmania vaccine" ;
    rdfs:seeAlso "MeSH: D054332" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38568
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38568
    ] .

obo:VO_0000763
    obo:IAO_0000115 "A bacterial vaccine that prevents infection with Vibrio cholera." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "cholera vaccine" ;
    a owl:Class ;
    rdfs:label "Vibrio cholerae vaccine" ;
    rdfs:seeAlso "MeSH: D022121" ;
    rdfs:subClassOf obo:VO_0000566, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_666
    ] .

obo:VO_0000764
    obo:IAO_0000115 "A vaccine that prevents Lyme disease caused by Borrelia burgdorferi." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Borrelia burgdorferi vaccine" ;
    a owl:Class ;
    rdfs:label "Lyme disease vaccine" ;
    rdfs:seeAlso "MeSH: D022123" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0000765
    obo:IAO_0000115 "A bacterial vaccine that prevents against Bordetella pertussis infection that causes pertussis or whooping cough." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Pertussis vaccine" ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis vaccine" ;
    rdfs:seeAlso "MeSH: D010567" ;
    rdfs:subClassOf obo:VO_0000587 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000587
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_520
            ]
        )
    ] .

obo:VO_0000766
    obo:IAO_0000115 "A bacterial vaccine that protects against infection with Pseudomonas." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Pseudomonas vaccine" ;
    rdfs:seeAlso "MeSH: D054406" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_286
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_286
    ] .

obo:VO_0000767
    obo:IAO_0000115 "A bacterial vaccine that protects against diseases caused by various species of Rickettsia. Typhus is any of several similar diseases caused by Rickettsia bacteria. So Rickettsial vaccine is also called typhus vaccine. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "typhus vaccine" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Typhus_vaccine", "WEB: http://www.violinet.org/vaxquery/query_detail.php?c_pathogen_id=108" ;
    a owl:Class ;
    rdfs:label "Rickettsial vaccine" ;
    rdfs:seeAlso "MeSH: D012290" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_780
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_780
    ] .

obo:VO_0000768
    obo:IAO_0000115 "A bacterial vaccine that protects against infections by various Salmonella species." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Salmonella" ;
    a owl:Class ;
    rdfs:label "Salmonella vaccine" ;
    rdfs:seeAlso "MeSH: D022562" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0000769
    obo:IAO_0000115 "A bacterial vaccine that protects against infections with Shigella species." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Shigella vaccine" ;
    rdfs:seeAlso "MeSH: D022281" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_620
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_620
    ] .

obo:VO_0000770
    obo:IAO_0000115 "A bacterial vaccine that protects against infection with Staphylococcus." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Staph vaccine", "Staphylococcus vaccine" ;
    a owl:Class ;
    rdfs:label "Staphylococcal vaccine" ;
    rdfs:seeAlso "MeSH: D013209" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1279
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1279
    ] .

obo:VO_0000771
    obo:IAO_0000115 "BCG Vaccine is a Mycobacterium tuberculosis vaccine that is a live attenuated strain of Mycobacterium bovis (Bacillus Calmette Guerin; BCG)." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Bacillus Calmette Guerin" ;
    a owl:Class ;
    rdfs:label "BCG vaccine" ;
    rdfs:seeAlso "CVX: 19" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001014
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000772
    obo:IAO_0000115 "A bacterial vaccine that prevents streptococcal infections." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Streptococcus vaccine" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Streptococcus" ;
    a owl:Class ;
    rdfs:label "Streptococcal vaccine" ;
    rdfs:seeAlso "MeSH: D022541" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1301
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1301
    ] .

obo:VO_0000773
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "MSP3-LSP with aluminium hydroxide" ;
    rdfs:seeAlso "PMID: 17280744" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000774
    obo:IAO_0000115 "RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. PMID: 15488216." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/?term=15488216" ;
    a owl:Class ;
    rdfs:label "P. falciparum RTS,S/AS02A" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0011218
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000775
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum MSP1 from transgenic mice with Freund's adjuvant" ;
    rdfs:seeAlso "PMID: 11752405" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010958
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000776
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "P. vivax PVS25 with Montanide ISA-720" ;
    rdfs:seeAlso "PMID: 16291764" ;
    rdfs:subClassOf obo:VO_0000758, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010957
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000777
    obo:IAO_0000115 "A recombinant E. coli-expressed protein based upon the apical membrane antigen-1 (AMA-1) of the 3D7 clone formulated with the AS02A adjuvant. PMID: 17442466." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "'P. falciparum FMP1/AS02A" ;
    rdfs:seeAlso "PMID: 17442466" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000894 ;
        owl:someValuesFrom obo:VO_0010923
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000778
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum ABRA protein vaccine" ;
    rdfs:seeAlso "PMID: 11489167", "PMID: 9400530" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010926
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000779
    obo:IAO_0000115 "An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus NP protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "NP-VRP" ;
    rdfs:subClassOf obo:VO_0000726 .

obo:VO_0000780
    obo:IAO_0000116 "An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus GP protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "GP-VRP" ;
    rdfs:subClassOf obo:VO_0000726 .

obo:VO_0000781
    obo:IAO_0000115 "An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP24 protein." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "alphavirus replicon expressing VP24" ;
    a owl:Class ;
    rdfs:label "VRP expressing VP24" ;
    rdfs:seeAlso "PMID: 11485406" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010866
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000782
    obo:IAO_0000115 "An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP30 protein." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "alphavirus replicon expressing VP30" ;
    a owl:Class ;
    rdfs:label "VRP expressing VP30" ;
    rdfs:seeAlso "PMID: 11485406" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010867
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000783
    obo:IAO_0000115 "An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP35 protein." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "alphavirus replicon expressing VP35" ;
    a owl:Class ;
    rdfs:label "VRP expressing VP35" ;
    rdfs:seeAlso "PMID: 11485406" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000784
    obo:IAO_0000115 "An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP40 protein." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "alphavirus replicon expressing VP40" ;
    a owl:Class ;
    rdfs:label "VRP expressing VP40" ;
    rdfs:seeAlso "PMID: 11485406" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010868
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000785
    obo:IAO_0000115 "A DNA vaccine that encodes for a secreted form of Ebola virus GP protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine expressing sGP" ;
    rdfs:seeAlso "PMID: 9427604" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010858
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000786
    obo:IAO_0000115 "A vaccine combination that includes a DNA vaccine and a recombinant adenovirus Ad5 expressing the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5 vaccine is used for boosting. PMID: 11797011." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA and adenoviral vector Ad5 expressing SIV gag protein" ;
    rdfs:seeAlso "PMID: 11797011" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010949
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000787
    obo:IAO_0000116 """A gene that is a pathogen gene used for vaccine preparation or a host gene encoding for an immune factor important in induction of protective immunity.
a vaccine-associated gene that exists in a pathogen and has been engineered for vaccine develoment. This gene can encode for protective antigen that is overexpressed for vaccine development. This gene can also be a virulence factor that is mutated to attenuate a virulent pathogen with the purpose of making attenuated vaccine.""", "The term 'gene' has appears in several ontologies, such as Sequence Ontology (SO) and Protein Ontology (PRO). We may choose to use a 'gene' term from other ontologies. The 'gene' term in SO has ID: SO:0000704." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "gene - Obsolete" ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0000788
    obo:IAO_0000115 "A recombinant adenovirus (Ad5) expressing the codon-optimized SIV gag gene. PMID: 11797011." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "adenoviral vector Ad5 expressing SIV gag protein" ;
    rdfs:seeAlso "PMID: 11797011" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010949
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000789
    obo:IAO_0000115 "A vaccine combination that includes a DNA vaccine and a replication-defective chimeric Ad5 vector with the Ad35 fiber (Ad5/35) that express the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5/35 vaccine is used for boosting. PMID: 16079886." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA and Ad5/35 vector expressing HIV gp160 protein" ;
    rdfs:seeAlso "PMID: 16079886" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010937
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000790
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella gene" ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0000791
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human gene" ;
    rdfs:subClassOf obo:OGG_0000000002 .

obo:VO_0000792
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "mouse gene" ;
    rdfs:subClassOf obo:OGG_0000000002 .

obo:VO_0000793
    obo:IAO_0000115 "A Brucella gene that is from B. abortus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus gene" ;
    rdfs:subClassOf obo:VO_0000790, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_235
    ] .

obo:VO_0000794
    obo:IAO_0000115 "A Brucella abortus gene that has the name wboA and comes from strain 2308. " ;
    obo:IAO_0000116 "Brucella abortus gene wboA is interrupted in Brucella abortus cattle vaccine RB51." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "wboA from B. abortus strain 2308" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_359391
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0000795
    obo:IAO_0000116 "Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "mouse Ifng" ;
    rdfs:subClassOf obo:VO_0000792 .

obo:VO_0000796
    obo:IAO_0000116 "Interferon-gamma (IFN-g) is an indicative of Th1 immune response." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human ifng" ;
    rdfs:subClassOf obo:VO_0000791 .

obo:VO_0000797
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "cattle gene" ;
    rdfs:subClassOf obo:OGG_0000000002 .

obo:VO_0000798
    obo:IAO_0000116 "Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "cattle Ifng" ;
    rdfs:subClassOf obo:VO_0000797 .

obo:VO_0000799
    obo:IAO_0000115 "an object property that represents a mutational relation between a vaccine organism and another material (e.g., gene or protein). the mutated material initially exists in the original wildtype organism. " ;
    obo:IAO_0000117 "YH" ;
    a owl:ObjectProperty ;
    rdfs:label "vaccine organism has mutation" .

obo:VO_0000800
    obo:IAO_0000115 "a storage process that is specifically for vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine storage" ;
    rdfs:subClassOf obo:OBI_0302893 .

obo:VO_0000801
    obo:IAO_0000115 "a vaccine storage that is execuated at room temperature. Room temperature is also referred to as ambient temperature. Room temperature denotes a certain temperature within enclosed space at which humans are accustomed. Room temperature is usually indicated by general human comfort, with the common range of 10 degree C (50 degree F) to 28 degree C (82.4 degree F)." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine storage at room temperature" ;
    rdfs:subClassOf obo:VO_0000800 .

obo:VO_0000802
    obo:IAO_0000115 "vaccine storage that is executed in refrigerator, usually 0-10^C." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine storage in refrigerator" ;
    rdfs:subClassOf obo:VO_0000800 .

obo:VO_0000803
    obo:IAO_0000115 "vaccine storage that is executed in freezer under 0^C." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine storage in freezer" ;
    rdfs:subClassOf obo:VO_0000800 .

obo:VO_0000804
    obo:IAO_0000115 "Effectiveness is physical quality that represents the capability of a single physical entity (e.g., vaccine) producing an effect (e.g, protection against a disease)." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "effectiveness" ;
    rdfs:subClassOf obo:PATO_0001018 .

obo:VO_0000805
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "effective" ;
    rdfs:subClassOf obo:VO_0000804 .

obo:VO_0000806
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "ineffective" ;
    rdfs:subClassOf obo:VO_0000804 .

obo:VO_0000807
    obo:IAO_0000115 "a vaccine role that indicates the vaccine being a toxoid vaccine. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "toxoid vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0000808
    obo:IAO_0000115 "A vaccination process that is implemented fast." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "vaccine rapid implementation" ;
    a owl:Class ;
    rdfs:label "rapid vaccination" ;
    rdfs:subClassOf obo:VO_0000002 .

obo:VO_0000809
    obo:IAO_0000115 "A measure datum that measures the coverage of vaccination in a specific area during a specific time period." ;
    obo:IAO_0000117 "YH, MC" ;
    obo:IAO_0000118 "immunization coverage" ;
    obo:IAO_0000119 "WEB: http://www.sanofipasteur.com/sanofi-pasteur2/front/index.jsp?siteCode=SP_CORP&codeRubrique=19", "WEB: http://www.who.int/immunization_monitoring/routine/immunization_coverage/en/" ;
    a owl:Class ;
    rdfs:label "vaccination coverage" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0000810
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSCAR . CMV promotor is used." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pSCAR DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 18022294; PMID: 19712769." ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000811
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine epitope" ;
    rdfs:subClassOf obo:OBI_1110034 .

obo:VO_0000812
    obo:IAO_0000115 "a licensed vaccine role that indicates the vaccine occurs in USA." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "USA licensed vaccine role" ;
    rdfs:subClassOf obo:VO_0000630 .

obo:VO_0000813
    obo:IAO_0000115 "a cattle vaccine with license that is used in USA." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "USA licensed cattle vaccine" ;
    rdfs:subClassOf obo:VO_0000643 .

obo:VO_0000814
    obo:IAO_0000116 "vaccination dose is a dose of vaccine that is used in a vaccination. Vaccination dose may be and may be not the same as the vaccine dose." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccination dose" ;
    rdfs:subClassOf obo:OBI_0000984 .

obo:VO_0000815
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "monthly" ;
    rdfs:subClassOf obo:PATO_0000044 .

obo:VO_0000816
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "biweekly" ;
    rdfs:subClassOf obo:PATO_0000044 .

obo:VO_0000817
    obo:IAO_0000115 "A HIV vaccine that is composed of a DNA vaccine expressing conserved, multiple HIV epitopes. PMID: 16359234." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine expressing multiple HIV epitopes" ;
    rdfs:seeAlso "PMID: 16359234" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000818
    obo:IAO_0000117 "YH", "an object property that specifies a relation between a vaccine and a vaccine virmugen. " ;
    a owl:ObjectProperty ;
    rdfs:comment """This is a short cut relation.
Domain: vaccine
Range: a gene

Shortcut:
is_specified_output_of some 
('preparation of gene mutant vaccine' and (has_specified_input some gene))""" ;
    rdfs:label "has vaccine virmugen" .

obo:VO_0000819
    obo:IAO_0000115 "A HIV vaccine that is made of recombinant HIV gp120 protein adjuvanted with the adjuvant NanoEmulsion. PMID: 18260780." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant HIV gp120 with adjuvant NanoEmulsion" ;
    rdfs:seeAlso "PMID: 18260780" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ] .

obo:VO_0000820
    obo:IAO_0000115 "An Aeromonas bacterial vaccine that is used to protect against Aeromonas salmonicida infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Aeromonas salmonicida vaccine" ;
    rdfs:subClassOf obo:VO_0000589, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_645
    ] .

obo:VO_0000821
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.vetechinc.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Vetech Labs" .

obo:VO_0000822
    obo:IAO_0000115 "Gag-VRPs is a cocktail vaccine of V3014-packaged VRPs expressing the SIVsm H-4i nonmyristylated matrix-capsid region, full-length gp160, and a secreted form of gp160 (gp140). PMID: 12120997." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Gag-VRPs" ;
    rdfs:seeAlso "PMID: 10462249", "PMID: 12120997" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000823
    obo:IAO_0000115 "a bacterial vaccine against V. anguillarum infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Vibrio anguillarum vaccine" ;
    rdfs:subClassOf obo:VO_0000566, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_55601
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000566
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_55601
            ]
        )
    ] .

obo:VO_0000824
    obo:IAO_0000115 "A recombinant modified vaccinia Ankara (MVA) expressing HIV Gag, Pol, and Env proteins. PMID: 16472543." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "MVA expressing HIV Gag, Pol and Env proteins" ;
    rdfs:seeAlso "PMID: 16472543" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000825
    obo:IAO_0000115 "A SIV vaccine that is composed of a DNA vaccine and a poxvirus vector expressing the same SIV antigens. PMID: 15258286." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "DNA and poxvirus priming-boosting SIV vaccine" ;
    rdfs:seeAlso "PMID: 15258286" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ] .

obo:VO_0000826
    obo:IAO_0000115 "A B. abortus vaccine that is recombinant B. abortus strain 19 vaccine with the p39 gene deletion." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. abortus S19 P39 deletion mutant" ;
    obo:IAO_0000119 "PMID: 9784574" ;
    a owl:Class ;
    rdfs:label "Brucella abortus S19 with P39 deletion" ;
    rdfs:subClassOf obo:VO_0001134, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000827
    obo:IAO_0000116 "A Yersinia pestis vaccine that uses a recombinant Ad5-based vector (E1a, partial E1b, and partial E3 deletion) to express Y. pestis V antigen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "AdsecV" ;
    rdfs:seeAlso "PMID: 17041851" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010876
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000828
    obo:IAO_0000115 "A Yersinia pestis vaccine that is a pigmentation negative mutant of Y. pestis derived from a fully virulent strain." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Yersinia EV-76" ;
    a owl:Class ;
    rdfs:label "Yersinia EV76" ;
    rdfs:seeAlso "PMID: 4988692", "PMID: 8578841" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000829
    obo:IAO_0000115 "A Yersinia pestis subunit vaccine that uses Y. pestis F1 protein as antigen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Y. pestis F1 protein vaccine" ;
    rdfs:seeAlso "PMID: 312163", "PMID: 8675324" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010870
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011004
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10114
    ] .

obo:VO_0000830
    obo:IAO_0000115 "A Y. pestis subunit vaccine that uses recombinant F1 and V antigens. PMID: 312163." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "rF1 + rV vaccine" ;
    rdfs:seeAlso "PMID: 10930691", "PMID: 12922126", "PMID: 15908389" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0000831
    obo:IAO_0000115 "A Y. pestis subunit vaccine that uses recombinant Y. pestis V antigen. PMID: 7622205." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Recombinant Y. pestis V antigen vaccine" ;
    rdfs:seeAlso "PMID: 7622205" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010874
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000832
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "modified Y. pestis with TLR4-stimulating LPS" ;
    rdfs:seeAlso "PMID: 16980981" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000833
    obo:IAO_0000115 "A Yersinia pestis subunit vaccine that contains staphylococcal protein A-V antigen fusion peptide (PAV). PMID: 7622225." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Yersinia PAV" ;
    rdfs:seeAlso "PMID: 7622225" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000834
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant Y. pestis YopD protein vaccine" ;
    rdfs:seeAlso "PMID: 10024607", "PMID: 8890210" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010878
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000835
    obo:IAO_0000116 "In vitro-cultured merozoites, chemically inactivated" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Epm vaccine" ;
    rdfs:subClassOf obo:VO_0000935, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000205 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000836
    obo:IAO_0000115 "A Y. pestis subunit vaccine that uses Y. pestis YscF protein as antigen. PMID: 15978133." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Y. pestis YscF subunit vaccine" ;
    rdfs:seeAlso "PMID: 15978133" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000837
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "microencapsulated Caf1 and LcrV vaccine" ;
    rdfs:seeAlso "PMID: 16546306" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000838
    obo:IAO_0000116 "Live temperature-sensitive mutant strain for subcutaneous or intramuscular injection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Ovilis Enzovax" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000839
    obo:IAO_0000116 "Fowlpox virus-vectored H5" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Trovac AI H5" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000840
    obo:IAO_0000115 "A Y. pestis vaccine that uses the recombinant V10 (rV10), a variant (lacking residues 271 to 300) of Yersinia pestis LcrV. PMID: 16861680." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant Yersinia rV10 vaccine" ;
    rdfs:seeAlso "PMID: 16861680" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000841
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.pfizerah.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Pfizer Animal Health" .

obo:VO_0000842
    obo:IAO_0000116 "Killed oral vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "AquaVac ERM" ;
    rdfs:subClassOf obo:VO_0001035, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8022
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001174 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000843
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Feline leukemia virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11768
    ] .

obo:VO_0000844
    obo:IAO_0000116 "Live temperature-sensitive mutant strain; spray inhalation or drinking water" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Art Vax" ;
    rdfs:subClassOf obo:VO_0001114, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9005
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001174 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000845
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "VSV vector expressing Y. pestis lcrV" ;
    rdfs:seeAlso "PMID: 16959385" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000846
    obo:IAO_0000117 "YH" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "BIOPHARM" .

obo:VO_0000847
    obo:IAO_0000115 "A formalin-inactivated preparation that was manufactured by Cutter Biologicals (a division of Miles Laboratories, Inc.). It is now available only from Greer Laboratories, Inc. The killed or inactivated plague vaccine is prepared from Y. pestis organisms grown in artificial media and then inactivated in formaldehyde. URL: http://www.cdc.gov/mmwr/preview/mmwrhtml/00044836.htm" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Plague vaccine USP" ;
    rdfs:seeAlso "PMID: 8578841" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000848 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000848
    obo:IAO_0000117 "YH" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Cutter Biological" .

obo:VO_0000849
    obo:IAO_0000115 "IMPROVAC is a vaccine that stimulates the pig’s own immune system to produce specific antibodies against GnRF. This temporarily inhibits testes function and thus stops the production and accumulation of boar taint-causing compounds." ;
    obo:IAO_0000116 "Peptide-protein conjugate and water-miscible adjuvant; control of boar taint" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.improvac.co.nz/sites/improvac/en-nz/Pages/productoverview.aspx" ;
    a owl:Class ;
    rdfs:label "Improvac" ;
    rdfs:subClassOf obo:VO_0000759, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000972
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000850
    obo:IAO_0000115 "a vaccine component that is added to the immunogen by the vaccine manufacturer for a specific purpose. Additives include adjuvants, preservatives and stablizers, as well as materials that are added to affect pH and isotonicity." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73." ;
    a owl:Class ;
    rdfs:label "vaccine additive" ;
    rdfs:subClassOf obo:VO_0000179 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000415
            ]
        )
    ] .

obo:VO_0000851
    obo:IAO_0000115 """vaccine preservative is an vaccine additive that is added to a vaccine formulation to prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during use.
Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73.""" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "antimicrobial agent in vaccine" ;
    a owl:Class ;
    rdfs:label "vaccine preservative" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000885
            ]
        )
    ] .

obo:VO_0000852
    obo:IAO_0000116 "Killed vaccine against periodontitis" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Periovac" ;
    rdfs:subClassOf obo:VO_0000865, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_111105
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:VO_0000879
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000853
    obo:IAO_0000115 "a vaccine additive that helps to protect the vaccine from adverse conditions such as the freeze-drying process (for those vaccines that are freeze-dried) or heat." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 75." ;
    a owl:Class ;
    rdfs:label "vaccine stabilizer" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0003026
            ]
        )
    ] .

obo:VO_0000854
    obo:IAO_0000115 "a vaccine component that remains from the vaccine manufacturing process." ;
    obo:IAO_0000116 "Although no all manufacturing residuals may be identified and quantified, their presence and quantity is assumed to be constant because of the constancy of the manufacturing process." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73." ;
    a owl:Class ;
    rdfs:label "vaccine residual" ;
    rdfs:subClassOf obo:VO_0000179 .

obo:VO_0000855
    obo:IAO_0000115 "a vaccine residual that is used to inactivate bacteria and viruses or to detoxify bacterial toxins. For example, formaldehyde is a frequently used inactivation agent in vaccine preparation." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78." ;
    a owl:Class ;
    rdfs:label "inactivation residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000854 .

obo:VO_0000856
    obo:IAO_0000115 "a vaccine residual that is generatead from cell culture for vaccine preparation. Examples include: antibiotics, sensitizing substances, bacterial and cellular residuals, and adventitious agents." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78-81." ;
    a owl:Class ;
    rdfs:label "cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000854 .

obo:VO_0000857
    obo:IAO_0000116 "Immune correlate of protection is a host immune response to vaccine that correlates with protective induced by the vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine-induced immune correlate of protection" ;
    rdfs:subClassOf obo:VO_0000288, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000287
    ] .

obo:VO_0000858
    obo:IAO_0000115 "Serological correlate of protection is an immune correlate of protection that is reflected by serologic antibody levels." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "serologic correlate of protection" ;
    rdfs:subClassOf obo:VO_0000857 .

obo:VO_0000859
    obo:IAO_0000115 "A cell mediated immune correlate of protection is an immune correlate of protection that is reflected by a cell mediated immune response." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "cell mediated immune correlate of protection" ;
    rdfs:subClassOf obo:VO_0000857 .

obo:VO_0000860
    obo:IAO_0000115 "Vaccine effectiveness is an effectiveness associated with a vaccine." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71." ;
    a owl:Class ;
    rdfs:label "vaccine effectiveness" ;
    rdfs:subClassOf obo:VO_0000804 .

obo:VO_0000861
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.bioproperties.com.au/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Bioproperties" .

obo:VO_0000862
    obo:IAO_0000116 "Canada is a country that exists in north America." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Canada" ;
    rdfs:subClassOf obo:VO_0010632 .

obo:VO_0000863
    obo:IAO_0000116 "In vitro-cultured supernatant antigens, reduce clinical disease" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Pirodog" ;
    rdfs:subClassOf obo:VO_0001074, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000864
    obo:IAO_0000115 "a licensed status that occurs in Canada." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Canada licensed vaccine role" ;
    rdfs:subClassOf obo:VO_0000630 .

obo:VO_0000865
    obo:IAO_0000115 "a bacterial vaccine against Porphyromonas gulae infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Porphyromonas gulae vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_836
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_836
    ] .

obo:VO_0000866
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Fluviral S/F" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000867
    obo:IAO_0000115 "Influvac is an Influenza virus vaccine that is manufactured by Solvay Pharma." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Influvac" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000869 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000868
    obo:IAO_0000115 "Vaxigrip is an Influenza virus vaccine that is manufactured by 'Sanofi Pasteur Limited." ;
    obo:IAO_0000117 "YH, Melanie" ;
    a owl:Class ;
    rdfs:label "Vaxigrip" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000869
    obo:IAO_0000117 "YH" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Solvay Pharmaceuticals" .

obo:VO_0000870
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Babesia bigemina vaccine by local veterinary institutes" ;
    rdfs:subClassOf obo:VO_0001033, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001079 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000871
    obo:IAO_0000116 "Canarypox virus-vectored vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Purevax Feline Rabies" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000872
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Babesia bovis vaccine by local veterinary institutes" ;
    rdfs:subClassOf obo:VO_0000925, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001079 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000873
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "pGPA-incorporated microemulsion" ;
    a owl:Class ;
    rdfs:label "PGA/ME" ;
    rdfs:seeAlso "PMID: 16730934" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000874
    obo:IAO_0000115 "Anthrax Spore Vaccine is a B. anthracis vaccine that is prepared with a relatively nonpathogenic, noncapsulated variant strain of B. anthracis, originally developed at the Onderstepoort Laboratory, Pretoria, South Africa. Further work was conducted in England, India and in many other countries. Vaccine Strain is Sterne 34F2. The vaccine is a suspension of viable Bacillus anthracis spores in saponin." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "B. anthracis Sterne strain spore vaccine" ;
    a owl:Class ;
    rdfs:label "Anthrax Spore Vaccine" ;
    rdfs:seeAlso "PMID: 3084385" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10141
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9788
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9935
    ] .

obo:VO_0000875
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "pSecTag-PA83" ;
    rdfs:seeAlso "PMID: 15293452" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000876
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "pCMV/ER-PA83" ;
    rdfs:seeAlso "PMID: 15293452" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0000877
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "https://www.webstervet.com/app.aspx" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Websters Animal Health" .

obo:VO_0000878
    obo:IAO_0000116 "Canarypox virus-vectored vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "RECOMBITEKEquine WNV" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000879
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Porphyromonas denticanis" ;
    rdfs:subClassOf obo:NCBITaxon_836 .

obo:VO_0000880
    obo:IAO_0000115 "pCLF4 is a Bacillus anthracis vaccine that contains the N-terminal region (amino acids [aa] 10-254) of Bacillus anthracis LF cloned into the pCI expression plasmid." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "pCLF4" ;
    rdfs:seeAlso "PMID: 11401993", "PMID: 15068841" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010873
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9986
    ] .

obo:VO_0000881
    obo:IAO_0000115 "Equity Oestrus Control Vaccine for Horses is prepared from an analogue of gonadotropin releasing factor (GnRF) linked to a carrier protein. It has an adjuvant that enhances the level and duration of the immune response to GnRF with minimal injection site reactivity. It is used as an aid in the control of oestrus and oestrus-related behaviour in fillies and mares not intended for breeding." ;
    obo:IAO_0000116 "Peptide-protein conjugate and proprietary adjuvant (immunostimulating complex); control of estrus and estrus-related behavior" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Equity Oestrus Control Vaccine for Horses" ;
    obo:IAO_0000119 "WEB: https://www.pfizeranimalhealth.com.au/products/352/equityreg-oestrus-control-vaccine.aspx" ;
    a owl:Class ;
    rdfs:label "Equity" ;
    rdfs:subClassOf obo:VO_0000759, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000972
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000882
    a owl:Class ;
    rdfs:label "single-dose Vaxigrip" ;
    rdfs:subClassOf obo:VO_0000868 .

obo:VO_0000883
    obo:IAO_0000116 "The difference between single-dose and multi-dose Vaxigrip is that multi-dose Vaxigrip contains preservative thimoseral.", "We still have not made it defined class since we still need to figure out how to represent multi-dose vs. single dose. The previous method discussed brief needs vetting. --YH" ;
    obo:IAO_0000117 "YH, Melanie, and Allen" ;
    a owl:Class ;
    rdfs:label "multi-dose Vaxigrip" ;
    rdfs:subClassOf obo:VO_0000868, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ] .

obo:VO_0000884
    obo:IAO_0000115 "a mineral salt vaccine adjuvant that is composed of aluminum salt." ;
    obo:IAO_0000117 "Aluminum vaccine adjuvant is a vaccine adjuvant that is composed of some aluminum compound.", "YH" ;
    a owl:Class ;
    rdfs:label "aluminum vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000093 .

obo:VO_0000885
    obo:IAO_0000115 "a role inhers in a vaccine component that when added into a vccine formmulation, it can prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during administrating process or the manufacturing process." ;
    obo:IAO_0000117 "YH,YL" ;
    obo:IAO_0000119 "P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al." ;
    a owl:Class ;
    rdfs:comment "The CFR requires that, with certain defined exceptions, preservatives must be added to mulitdose vials of vaccine. (P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al.)" ;
    rdfs:label "vaccine preservative role" ;
    rdfs:subClassOf obo:VO_0000415 .

obo:VO_0000886
    obo:IAO_0000117 "YH", "a route of administration that located in the mouth" ;
    a owl:Class ;
    rdfs:label "oral route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0000165
    ] .

obo:VO_0000887
    obo:IAO_0000115 "a route of administration that inject the material(such as vaccines, allergens) into the skin itself." ;
    obo:IAO_0000117 "YH,YL" ;
    obo:IAO_0000118 "intradermal injection route" ;
    oboInOwl:hasSynonym "I.D." ;
    a owl:Class ;
    rdfs:label "intradermal route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0002097
    ] .

obo:VO_0000888
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "phenol vaccine preservative" ;
    rdfs:subClassOf obo:VO_0000851 .

obo:VO_0000889
    obo:IAO_0000116 "Recombinant ApxII, TbpB, CysL, OmlA(1), and OmlA(2) proteins" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "PleuroStar APP" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000964 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000890
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.colorado-serum.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Colorado Serum Company CZ Veterinaria" .

obo:VO_0000891
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "phenoxy ethanol vaccine preservative" ;
    rdfs:subClassOf obo:VO_0000851, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000885
    ] .

obo:VO_0000892
    obo:IAO_0000117 "YH, ZX" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Biken" .

obo:VO_0000893
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.schering-plough.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Schering-Plough" .

obo:VO_0000894
    obo:IAO_0000117 "YH", "a 'has subunit vaccine antigen' relation that indicates the antigen is protective." ;
    a owl:ObjectProperty ;
    rdfs:label "has subunit vaccine protective antigen" ;
    rdfs:subPropertyOf obo:VO_0000525 .

obo:VO_0000895
    obo:IAO_0000117 "YH, ZX" ;
    oboInOwl:hasURI "http://www.baxter.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Baxter Healthcare Corporation" .

obo:VO_0000896
    obo:IAO_0000117 "YH, ZX" ;
    oboInOwl:hasURI "http://www.merckfrosst.ca/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Merck Frosst" .

obo:VO_0000897
    obo:IAO_0000115 "Age at vaccination is the age of an experiment animal at the time of vaccination." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "age at vaccination" ;
    rdfs:subClassOf obo:PATO_0000011 .

obo:VO_0000898
    obo:IAO_0000116 "Culture-derived schizonts" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Theileria annulata vaccine by local veterinary institutes" ;
    rdfs:subClassOf obo:VO_0000909, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_77054
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001079 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000899
    obo:IAO_0000115 "dose is a measurement data that measures the quantity of something that may be eaten by or administered to an organism, or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses." ;
    obo:IAO_0000117 "YH, MC" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Dose_%28biochemistry%29" ;
    a owl:Class ;
    rdfs:comment "obsolete on 2/1/2020, using the OBI dose term (OBI_0000984) instead." ;
    rdfs:label "dose - obsolete" ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0000900
    obo:IAO_0000115 "challenge dose is a dose of a virulent pathogen used for a vaccine challenge process." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "challenge dose" ;
    rdfs:subClassOf obo:OBI_0000984 .

obo:VO_0000901
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.bi-vetmedica.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Boehringer-Ingelheim Vetmedica, Inc" .

obo:VO_0000902
    obo:IAO_0000116 "Canarypox virus-vectored vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "PROTEQ-FLU (European Union)", "Recombitek (United States)" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000903
    obo:IAO_0000115 "Secondary vaccination is a vaccination that is performed immediately after the primary or the first vaccination." ;
    obo:IAO_0000117 "YH, Thom Todd" ;
    a owl:Class ;
    rdfs:label "secondary vaccination" ;
    rdfs:subClassOf obo:VO_0000708, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000062 ;
        owl:someValuesFrom obo:VO_0000707
    ] .

obo:VO_0000904
    obo:IAO_0000117 "YH, ZX" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "SBL Vaccine" .

obo:VO_0000905
    obo:IAO_0000117 "YH, ZX" ;
    oboInOwl:hasURI "http://www.wyeth.ca/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Wyeth Canada" .

obo:VO_0000906
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Eimeria vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5800
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5800
    ] .

obo:VO_0000907
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "surface antigens from the zona pellucida" ;
    rdfs:subClassOf obo:OBI_1110034 .

obo:VO_0000908
    obo:IAO_0000115 "is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:ObjectProperty ;
    rdfs:label "is_distributed_by" .

obo:VO_0000909
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Theileria annulata vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5874
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5874
    ] .

obo:VO_0000910
    obo:IAO_0000115 "vaccine allergen is a material entity that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals who has been vaccinated with a vaccine." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf" ;
    a owl:Class ;
    rdfs:label "vaccine allergen" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:BFO_0000040
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000091 ;
                owl:someValuesFrom obo:VO_0000713
            ]
        )
    ] .

obo:VO_0000911
    obo:IAO_0000115 "passive immunization that Immunity is transferred from mother to fetus through placental transfer of IgG or colostral transfer of IgA."@en ;
    obo:IAO_0000119 "http://pathmicro.med.sc.edu/ghaffar/immunization-ver2.htm"@en ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "passive immunization using natural maternal antibody" ;
    rdfs:subClassOf obo:VO_0000492 .

obo:VO_0000912
    obo:IAO_0000116 """Eegg protein may come from NCIS thesaurus egg - poultry, combination
of minimal anatomy terminology and NCBI taxonomy... Eventually, this term chicken egg protein allergen may become a cross product of sevreal ontology terms.""" ;
    obo:IAO_0000117 "YH, ZX, MC", "chicken egg protein allergen is a vaccine allergen that is composed of chicken egg protein." ;
    a owl:Class ;
    rdfs:label "chicken egg protein allergen" ;
    rdfs:subClassOf obo:VO_0000910 .

obo:VO_0000913
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "latex vaccine allergen" ;
    rdfs:subClassOf obo:VO_0000910 .

obo:VO_0000914
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.virbac.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Virbac" .

obo:VO_0000915
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "gelatin vaccine allergen" ;
    rdfs:subClassOf obo:VO_0000910 .

obo:VO_0000916
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "protamine sulfate vaccine allergen" ;
    rdfs:subClassOf obo:VO_0000910 .

obo:VO_0000917
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "polymyxin B vaccine allergen" ;
    rdfs:subClassOf obo:VO_0000910 .

obo:VO_0000918
    obo:IAO_0000116 "Canarypox virus-vectored vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "EURIFEL FeLV" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011068
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000919
    obo:IAO_0000115 "the vaccine component that is used as antigen to produce an immune responce protect against the specific pathogen or disease." ;
    obo:IAO_0000116 "This is a modified or partial form of the virus, bacteria or the toxin that causes the disease against which the vaccine protects. The vaccine antigen is altered from its original form so it no longer causes disease but it can produce an immune response.(Vaccine components FactSheet of NCIRS)" ;
    obo:IAO_0000117 "YL, YH" ;
    obo:IAO_0000118 "vaccine antigenic component" ;
    a owl:Class ;
    rdfs:comment "To create this term for cover some other vaccines such as cancer vaccine and so on." ;
    rdfs:label "vaccine antigen" ;
    rdfs:subClassOf obo:VO_0000179 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:OBI_0000237
            ]
        )
    ] .

obo:VO_0000920
    obo:IAO_0000115 "a cell culture residual in vaccine that is bovine albumin." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "bovine albumin cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000921
    obo:IAO_0000115 "a cell culture residual in vaccine that is bovine serum." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bovine serum cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000922
    obo:IAO_0000115 "a vaccine stablizer that is based on monosodium glutamate. " ;
    obo:IAO_0000117 "YL,YH" ;
    obo:IAO_0000118 "C5H8NNaO4" ;
    a owl:Class ;
    rdfs:comment "http://www.novaccine.com/vaccine-ingredients/results.asp?sc=13" ;
    rdfs:label "monosodium glutamate stabliizer" ;
    rdfs:subClassOf obo:VO_0003035, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_64220
    ] .

obo:VO_0000923
    obo:IAO_0000116 "Modified live virus" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "RECOMBITEK Corona MLV" ;
    rdfs:subClassOf obo:VO_0000932, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000924
    a owl:Class ;
    rdfs:label "glutaraldehyde vaccine additive" ;
    rdfs:subClassOf obo:VO_0000851, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000885
    ] .

obo:VO_0000925
    obo:IAO_0000116 "Infected blood from splenectomized calves" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Babesia bovis vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5865
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5865
    ] .

obo:VO_0000926
    obo:IAO_0000115 "a cell culture residual in vaccine that is human albumin." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human albumin cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000927
    obo:IAO_0000115 "a cell culture residual in vaccine that is human serum." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "human serum cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000928
    obo:IAO_0000116 "Reference: http://www.raboral.com/", "Vaccinia virus recombinant" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Raboral" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_13488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9654
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000929
    obo:IAO_0000115 "a vaccine stabilizer that is a polysorbate 20. It encourages the suspension of one liquid in another and has mild toxicity." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:comment "Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Reference: http://www.sciencelab.com/msds.php?msdsId=9926640 ", "http://www.novaccine.com/vaccine-ingredients/results.asp?sc=95" ;
    rdfs:label "polysorbate 20 vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0000853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0003026
    ] .

obo:VO_0000930
    obo:IAO_0000115 "a vaccine emulsifier that uses polysorbate 80, also known as polyoxyethylene sorbitan monooleate or Tween™ 80." ;
    obo:IAO_0000117 "YH,YL" ;
    obo:IAO_0000118 "Tween 80 vaccine emulsifier" ;
    obo:IAO_0000119 "WEB: http://www.wisegeek.org/what-is-polysorbate-80.htm " ;
    a owl:Class ;
    rdfs:comment "Tween 80 is an amber-colored, viscous liquid with a slightly bitter taste. The product is a derivative of sorbitol and oleic acid. " ;
    rdfs:label "polysorbate 80 vaccine emulsifier" ;
    rdfs:subClassOf obo:VO_0000310 .

obo:VO_0000931
    obo:IAO_0000115 "a cell culture residual in vaccine that is residual protein from cell culture. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine residual protein from cell culture" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000932
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "canine coronavirus vaccine" ;
    rdfs:subClassOf obo:VO_0004897, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ] .

obo:VO_0000933
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli CS3 in PLGA microspheres"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 3095" ;
    rdfs:subClassOf obo:VO_0000628 .

obo:VO_0000934
    obo:IAO_0000115 "a vaccine stabilizer that is specifically made by sorbitol." ;
    obo:IAO_0000117 "YH, YL" ;
    obo:IAO_0000118 "glucitol" ;
    a owl:Class ;
    rdfs:comment "Sorbitol, also known as glucitol, is a sugar alcohol that the human body metabolizes slowly. It can be obtained by reduction of glucose, changing the aldehyde group to a hydroxyl group. Sorbitol is found in apples, pears, peaches, and prunes. It is synthesized by sorbitol-6-phosphate dehydrogenase, and converted to fructose by succinate dehydrogenase and sorbitol dehydrogenase. Succinate dehydrogenase is an enzyme complex that participates in the citric acid cycle. (wikipedia)" ;
    rdfs:label "sorbitol vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0003034, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_30911
    ] .

obo:VO_0000935
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Sarcocystis neurona vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_42890
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_42890
    ] .

obo:VO_0000936
    obo:IAO_0000115 "A vaccine that is made of a TK-negative (TK -) and gI/gE-negative (gI/gE -) pseudorabies virus (PRV) mutant to protect pigs against Aujeszky's disease. Aujeszky's disease is also known as pseudorabies. It is a disease primarily of pigs and is caused by porcine herpesvirus 1. This disease is characterized by respiratory, reproductive and nervous signs." ;
    obo:IAO_0000116 """gE- and thymidine kinase-deleted
marker vaccine""" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Suvaxyn Aujeszky" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000205 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000937
    obo:IAO_0000115 "a cell culture residual in vaccine that is sucrose albumin." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "sucrose albumin cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000938
    obo:IAO_0000117 "YL" ;
    obo:IAO_0000119 "PMID: 19608270" ;
    a owl:Class ;
    rdfs:comment """\"XG is derived from Xanthomonas campestris, has a pentasaccharide repeating unit structure, and its terminus contains a mannose moiety which acts as a toll-like receptor 2 agonist.\" 

REF: Mucoadhesive liposomes for intranasal immunization with an avian influenza virus vaccine in chickens, by Chiou C. et al. Biomaterials, Volume 30, Issue 29, October 2009, Pages 5862-5868, ISSN 0142-9612, 10.1016/j.biomaterials.2009.06.046.
(http://www.sciencedirect.com/science/article/pii/S0142961209006371)""" ;
    rdfs:label "xanthan gum vaccine ajuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0000939
    obo:IAO_0000115 "a cell culture residual in vaccine that is from yeast extract." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "yeast extract cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000940
    obo:IAO_0000115 "a cell culture residual in vaccine that is yeast protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "yeast protein cell culture residual in vaccine" ;
    rdfs:subClassOf obo:VO_0000856 .

obo:VO_0000941
    obo:IAO_0000116 "DNA vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Apex-IHN" ;
    rdfs:subClassOf obo:VO_0012165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8015
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000971 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000942
    obo:IAO_0000118 "DTP-Hib vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Haemophilus b vaccine" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:VO_0000741
    ] .

obo:VO_0000943
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Poliovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:NCBITaxon_12080
                obo:NCBITaxon_12083
                obo:NCBITaxon_12086
            )
        ]
    ] .

obo:VO_0000944
    a owl:Class ;
    rdfs:label "V. cholerae and E. coli vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_562
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_666
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_562
                obo:NCBITaxon_666
            )
        ]
    ] .

obo:VO_0000945
    obo:IAO_0000115 "A Measles virus vaccine that is also used against Rubella virus infection.", "YH" ;
    a owl:Class ;
    rdfs:label "Measles-Rubella vaccine" ;
    rdfs:subClassOf obo:VO_0000654, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11041
    ] .

obo:VO_0000946
    obo:IAO_0000115 "https://www.nhsinform.scot/healthy-living/immunisation/vaccines/the-6-in-1-vaccine" ;
    obo:IAO_0000117 "A vaccine that protects against, Diphtheria, Tetanus, Pertussis (whooping cough), Polio, Hepatitis B, and Haemophilus influenzae type b.", "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTaP/IPV/HepB/Hib vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b-Hepatitis B vaccine" ;
    rdfs:subClassOf obo:VO_0000744, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0000947
    obo:IAO_0000116 "Live flavivirus chimera vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "PreveNile" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000948
    obo:IAO_0000115 "a bacterial vaccine against S. equi infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Streptococcus equi vaccine" ;
    rdfs:subClassOf obo:VO_0000772, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1336
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1336
    ] .

obo:VO_0000949
    obo:IAO_0000115 "a bacterial vaccine against Mycoplasma gallisepticum infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Mycoplasma gallisepticum vaccine" ;
    rdfs:subClassOf obo:VO_0000604, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2096
    ] .

obo:VO_0000950
    a owl:Class ;
    rdfs:label "Salmonella typhi-Hepatitis A vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12092
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_90370
    ] .

obo:VO_0000951
    obo:IAO_0000116 "Baculovirus recombinant E2 protein without emulsion" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Bayovac CSF E2" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001179 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000952
    obo:IAO_0000118 "Tick-borne virus vaccine" ;
    a owl:Class ;
    rdfs:label "Dhori virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11318
    ] .

obo:VO_0000953
    obo:IAO_0000115 "Pharyngeal mucosal route is an oral route of administration." ;
    obo:IAO_0000117 "TT, YH" ;
    a owl:Class ;
    rdfs:label "pharyngeal mucosal route" ;
    rdfs:subClassOf obo:VO_0000886 .

obo:VO_0000954
    obo:IAO_0000116 "Chimera virus on NDV backbone; field trials in 2007" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Intervet Avian Influenza virus vaccine" ;
    rdfs:subClassOf [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8782
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000642
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ] .

obo:VO_0000955
    a owl:Class ;
    rdfs:label "host survival to pathogen challenge after vaccination" ;
    rdfs:subClassOf obo:OBI_0000070 .

obo:VO_0000956
    obo:IAO_0000115 "a B. abortus vaccine that uses a conjugate vaccine format" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ] .

obo:VO_0000957
    obo:IAO_0000115 "a B. abortus vaccine that uses a recombinant vector. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus recombinant vector vaccine"@en ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000636
    ] .

obo:VO_0000958
    obo:IAO_0000115 "A vaccine that protects against Herpes simplex virus type 1 and 2." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Herpes simplex virus type 1 and 2" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000727, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0000959
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.embrex.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Embrex" .

obo:VO_0000960
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "killed infectious bursal disease Virus vaccine" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0000961
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated infectious bursal disease virus vaccine" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ] .

obo:VO_0000962
    obo:IAO_0000115 "An E. coli vaccine that uses a live mutant by knocking out one gene(s) from a wild type E. coli." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant E. coli mutant vaccine"@en ;
    rdfs:subClassOf obo:VO_0000619 .

obo:VO_0000963
    obo:IAO_0000115 "an E. coli vaccine that uses toxoid antigen" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli toxoid vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000964
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.ah.novartis.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Novartis Animal Health" .

obo:VO_0000965
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PubMed: http://www.ncbi.nlm.nih.gov/pubmed/9682399" ;
    a owl:Class ;
    rdfs:label "potato expressed E. coli LB-T vaccine"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 276" ;
    rdfs:subClassOf obo:VO_0000628 .

obo:VO_0000966
    obo:IAO_0000115 "An E. coli vaccine that uses a recombinant vaccine vector to express an E. coli antigen(s)" ;
    a owl:Class ;
    rdfs:label "recombinant vaccine vector E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000967
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23035176" ;
    a owl:Class ;
    rdfs:label "rBCG -Stx2B"@en ;
    rdfs:subClassOf obo:VO_0000966 .

obo:VO_0000968
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pBLUESCRIPT." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Davidson College - pBLUESCRIPT: Plasmids and Phages Combine For pBluescript [http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/Keogh/plasmids.html]" ;
    a owl:Class ;
    rdfs:comment "Derived from pUC vectors; cross between phages and plasmids and therefore in a special category called \"phagemids\" (Davidson College - pBLUESCRIPT)", "The plasmid length is: 2961" ;
    rdfs:label "pBLUESCRIPT DNA vaccine plasmid"@en ;
    rdfs:seeAlso "DNAVaxDB Plasmid ID: 180" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000969
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label nkCMVint." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A pUC-18-based plasmid; also contains intron A and an SV40 polyadenylation termination signal sequence. It has a CMV promoter." ;
    rdfs:label "nkCMVint DNA vaccine plasmid"@en ;
    rdfs:seeAlso "DNAVaxDB Plasmid ID: 181", "PMID: 9234529" ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001006 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000970
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli Tir protein Vaccine"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 3087" ;
    rdfs:subClassOf obo:VO_0000628 .

obo:VO_0000971
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Aqua Health" ;
    oboInOwl:hasURI "http://www.novartis.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Novartis" .

obo:VO_0000972
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "luteinizing hormone-releasing hormone" ;
    a owl:Class ;
    rdfs:label "LHRH" ;
    rdfs:subClassOf obo:FMA_12278 .

obo:VO_0000973
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli Shiga toxin 2B vaccine"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 282" ;
    rdfs:subClassOf obo:VO_0000628 .

obo:VO_0000974
    a owl:Class ;
    rdfs:label "inactivated E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000975
    obo:IAO_0000115 "An E. coli vaccine against uropathogenic E. coli infections" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "UPEC vaccine" ;
    a owl:Class ;
    rdfs:label "uropathogenic E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000976
    obo:IAO_0000115 "An E. coli vaccine against extraintestinal pathogenic E. coli infections" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "ExPEC vaccine" ;
    a owl:Class ;
    rdfs:label "extraintestinal pathogenic E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000977
    obo:IAO_0000115 "An E. coli vaccine against enterohemorrhagic E. coli infections" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "EHEC vaccine" ;
    a owl:Class ;
    rdfs:label "enterohemorrhagic E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0000978
    obo:IAO_0000117 "Kallan Roan, Yongqun He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm335836.htm"^^xsd:anyURI ;
    obo:VO_0003099 "Flublok"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Protein Sciences Corporation"^^xsd:anyURI ;
    obo:VO_0003160 "For active immunization against disease caused by influenza virus subtypes A and type B contained in the vaccine. Flublok is approved for use in persons 18 years of age and older."^^xsd:anyURI ;
    obo:VO_0003162 "125285"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Flublok"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003069 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000979
    obo:IAO_0000116 "Live or inactivated gE-deleted marker vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Bovilis IBR Marker" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000980
    obo:IAO_0000117 "Kallan Roan, Yongqun He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm328629.htm"^^xsd:anyURI ;
    obo:VO_0003099 "FLUCELVAX"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Seqirus, Inc."^^xsd:anyURI ;
    obo:VO_0003160 "For active immunization of persons 4 years of age and older for the prevention of influenza disease caused by influenza virus subtypes A and type B contained in the vaccine."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "125408"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Flucelvax"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003164 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000981
    obo:IAO_0000116 "Baculovirus recombinant E2 protein without emulsion" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Porcilis Pesti" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000982
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "FluMist Quadrivalent"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000343
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000694 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000983
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Fluarix Quadrivalent" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000984
    obo:IAO_0000115 "a tetanus vaccine manusfactured by Sanofi Pasteur Inc. that is only for booster use (not recommended for primary immunization)" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf" ;
    a owl:Class ;
    rdfs:label "Tetanus Toxoid (for Boost use Only) by Sanofi Pasteur Inc"@en ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000985
    obo:IAO_0000115 "a viral vaccine that is used to protect against fowl pox virus infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "fowl pox vaccine"@en ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10261
            ]
        )
    ] .

obo:VO_0000986
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian influenza vaccine"@en ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0001243 ;
                owl:someValuesFrom obo:NCBITaxon_9031
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11309
            ]
        )
    ] .

obo:VO_0000987
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bovine rhinotracheitis vaccine"@en ;
    rdfs:subClassOf [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10320
            ]
        )
    ] .

obo:VO_0000988
    obo:IAO_0000116 "Infection followed by drug treatment" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Theileria parva vaccine by local veterinary institutes" ;
    rdfs:subClassOf obo:VO_0001061, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001058 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000989
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.novusint.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Novus International" .

obo:VO_0000990
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "bovine parainfluenza 3 vaccine"@en ;
    rdfs:subClassOf [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11215
            ]
        )
    ] .

obo:VO_0000991
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pDONR221. The plasmid length is 4762." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2394/", "Invitrogen: http://tools.invitrogen.com/content/sfs/manuals/gateway_pdonr_vectors.pdf", "pDONR221 Sequence: http://tools.invitrogen.com/content/sfs/vectors/pdonr221_seq.txt" ;
    a owl:Class ;
    rdfs:label "pDONR221 DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000992
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCN3. The plasmid promoter is CMV." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCN3 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 19596416; PMID: 21059395." ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000993
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label V1R." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "V1R DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID:  11797011; PMID: 15258286" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000994
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Toxoplasma gondii vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0000995
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pVAC1 3.0. The manufacturer is Invitrogen." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pVAC1 3.0 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 20884037" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000996
    obo:IAO_0000115 "SpayVac is a contraceptive vaccine that has proven highly effective in deer and can be used to control populations. Refernce: http://terramar.bc.ca/." ;
    obo:IAO_0000116 "Crude ZPA preparation; supplied to research groups only", "no longer available" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "SpayVac" ;
    rdfs:subClassOf obo:VO_0000759, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000907
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9850
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001069 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0000997
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSin-CMV-Vac. The promoter is CMV." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pSin-CMV-Vac DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 22702835; PMID: 23637502" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000998
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pGACAG. The promoter is CAG and the antibiotics resistance gene is kanamycin." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pGACAG DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 17203206" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0000999
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pVCL1012. The promoter is HCMV and the manufacturer is Vical Inc." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pVCL1012 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 15652666" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0001000
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSCA1." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pSCA1 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 22819169" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0001001
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.biomunecompany.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Biomune" .

obo:VO_0001002
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label phCMV1.  This plasmid is 4200 base pairs long, has a CMV promoter, contains kanamycin and neomycin antibiotics resistance genes, and is manufactured by Genlantis. " ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "WEB: http://www.genlantis.com/faq-phcmv.html" ;
    a owl:Class ;
    rdfs:label "phCMV1 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 19540885" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0001003
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCJ-3.  This plasmid has a CMV promoter and a kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCJ-3 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 16949850" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0001004
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pcDNA3.1/V5-His.  This plasmid has a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pcDNA3.1/V5-His DNA vaccine plasmid"@en ;
    rdfs:seeAlso "PMID: 22445688" ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001005
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSecTag2 C.  This plasmid is 5167 base pairs long, has a CMV promoter and ampicillin and zeocin resistance genes." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "WEB: http://tools.invitrogen.com/content/sfs/manuals/psectag2_man.pdf" ;
    a owl:Class ;
    rdfs:label "pSecTag2 C DNA vaccine plasmid"@en ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000023 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001006
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Vical, Inc."@en ;
    foaf:homepage "http://www.vical.com/" .

obo:VO_0001007
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pBC12/CMV/IL-2." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "NIH AIDS Reagent Program - pBC12/CMV/IL-2: [https://www.aidsreagent.org/reagentdetail.cfm?t=expression_vectors&id=159]" ;
    a owl:Class ;
    rdfs:comment "Derived from plasmid pBC12/CMV; expresses IL-2 (NIH AIDS Reagent Program - pBC12/CMV/IL-2). Its length is: 4732." ;
    rdfs:label "pBC12/CMV/IL-2 DNA vaccine plasmid"@en ;
    rdfs:seeAlso "DNAVaxDB Plasmid ID: 182" ;
    rdfs:subClassOf obo:VO_0000435, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001006 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001008
    obo:IAO_0000116 "Cultured trophozoites, reduces disease and cyst shedding" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Giardiavax" ;
    rdfs:subClassOf obo:VO_0001083, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000205 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001009
    obo:IAO_0000115 "The plant-based Newcastle disease virus vaccine is a Newcastle disease virus vaccine that is developed by Dow AgroSciences LLC. It uses technology discovered at Washington University. It is the first plant-made animal vaccine approved for sale in the United States." ;
    obo:IAO_0000116 "HN recombinant produced in plant cell lines (registered but not on market)" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "plant-based Newcastle disease virus vaccine" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001219 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001010
    oboInOwl:hasURI "http://www.promega.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Promega"@en .

obo:VO_0001011
    obo:IAO_0000115 """a shortcut relation that equals to:
'processed material' and (is_specified_output_of some 'vaccine preparation') and ('has function' some ('vaccine function' and ('is realized by' only ('vaccine immunization' and (realizes some ('vaccine host role' and (role_of some 'organism' and has_disposition some disease)))))))).
The domain of this relation is a vaccine.
The range of this relation is a disease.""" ;
    obo:IAO_0000117 "Asiyah Yu Lin", "Oliver He" ;
    obo:IAO_0000118 "immunization against disease", "vaccine immunization against disease"@en ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "immunizes against disease" ;
    rdfs:range obo:DOID_4 .

obo:VO_0001012
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "classical swine fever virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0001013
    obo:IAO_0000115 "A Measles-Mumps-Rubella vaccine that is manufactured by Sanofi Aventis." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Morupar"@en ;
    rdfs:subClassOf obo:VO_0000731, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:CHEBI_52071
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:VO_0003026
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001014
    obo:IAO_0000115 "a live attenuated quality of a bacterial vaccine strain. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "bacterial vaccine organism live attenuated"@en ;
    rdfs:subClassOf obo:VO_0000173 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000173
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000052 ;
                owl:someValuesFrom obo:NCBITaxon_2
            ]
        )
    ] .

obo:VO_0001015
    obo:IAO_0000115 "a live attenuated quality of a virus vaccine strain. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "viral vaccine organism live attenuated"@en ;
    rdfs:subClassOf obo:VO_0000173 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000173
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000052 ;
                owl:someValuesFrom obo:NCBITaxon_10239
            ]
        )
    ] .

obo:VO_0001016
    obo:IAO_0000116 "Fowlpox virus vectored" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Vectormune FP-ND" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001017
    obo:IAO_0000115 "A vaccine that protects against Marek's; disease virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Marek's; disease virus" ;
    a owl:Class ;
    rdfs:label "live attenuated Marek's disease virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0012162, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ] .

obo:VO_0001018
    obo:IAO_0000115 "A viral vaccine that protects aganist Newcastle disease virus infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated Newcastle disease virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0001222 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0001222
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001015
            ]
        )
    ] .

obo:VO_0001019
    obo:IAO_0000115 "an avian reovirus vaccine that using live attenauted reovirus. " ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "live attenuated avian reovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0001513 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0001513
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001015
            ]
        )
    ] .

obo:VO_0001020
    obo:IAO_0000116 "Sporulated oocysts of several or all of the avian species" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Advent", "Coccivac", "Immucox", "Nobilis Cox ATM", "Paracox" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000821 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000893 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000989 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001021
    obo:IAO_0000115 "a feline panleukopenia virus vaccine where the virus used is live attenuated. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated feline panleukopenia virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000389 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000389
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001015
            ]
        )
    ] .

obo:VO_0001022
    obo:IAO_0000115 "Megan Vac1 is a Salmoneela vaccine that consists of a double gene-deleted S. enterica serovar Typhimurium strain and is designed for protection of broilers to reduce Salmonella contamination." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.fda.gov/ohrms/dockets/dockets/00n0504/00N-0504_emc-001650-02.pdf" ;
    a owl:Class ;
    rdfs:label "Megan Vac1" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001023
    obo:IAO_0000115 "a bacterial vaccine vector that uses TB vaccine BCG as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "BCG vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 33892" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001024
    obo:IAO_0000115 "an avian influenza vaccine that uses inactivated viral organism" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "inactivated avian influenza vaccine"@en ;
    rdfs:subClassOf obo:VO_0000461 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000461
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0000211
            ]
        )
    ] .

obo:VO_0001025
    obo:IAO_0000115 "a viral vaccine vector that uses a vesicular stomatitis virus (VSV) as the vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vesicular stomatitis virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11276" ;
    rdfs:subClassOf obo:VO_0001121 .

obo:VO_0001026
    obo:IAO_0000116 "Killed oral vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "AquaVac Furuvac" ;
    rdfs:subClassOf obo:VO_0000820, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8015
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001174 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001027
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.lahinternational.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Lohman Animal Health International" .

obo:VO_0001028
    obo:IAO_0000115 "a parasite vaccine vector using a live attenuated Leishmania tarentolae strain.  " ;
    obo:IAO_0000117 "Yongqun He, Carly Mantin" ;
    a owl:Class ;
    rdfs:label "Leishmania tarentolae vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 5689" ;
    rdfs:subClassOf obo:VO_0001034 .

obo:VO_0001029
    a owl:Class ;
    rdfs:label "autologous dendritic cell melanoma vaccine" ;
    rdfs:seeAlso "PMID:23969885" ;
    rdfs:subClassOf obo:VO_0000422 .

obo:VO_0001030
    a owl:Class ;
    rdfs:label "vaccine-induced mouse immune response"@en ;
    rdfs:subClassOf obo:VO_0000287, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000293 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_10090
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:OBI_0000725
                ]
            )
        ]
    ] .

obo:VO_0001031
    obo:IAO_0000112 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/21907709" ;
    obo:IAO_0000115 "a bacterial vaccine vector using a live attenuated Salmonella enterica strain SL3261.  " ;
    obo:IAO_0000117 "Yongqun He, Carly Mantin" ;
    a owl:Class ;
    rdfs:label "Salmonella typhimurium SL3261 vaccine vector"@en ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001032
    obo:IAO_0000112 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/21964456" ;
    obo:IAO_0000115 "a bacterial vaccine vector using a live attenuated Edwardsiella tarda strain EIB202" ;
    obo:IAO_0000117 "Yongqun He, Carly Mantin" ;
    a owl:Class ;
    rdfs:label "Edwardsiella tarda EIB202 vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 498217" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001033
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Babesia bigemina vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5866
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5866
    ] .

obo:VO_0001034
    obo:IAO_0000115 "a vaccine vector that uses a parasite as the vector." ;
    obo:IAO_0000117 "Yongqun He, Carly Martin" ;
    a owl:Class ;
    rdfs:label "parasite vaccine vector" ;
    rdfs:subClassOf obo:VO_0000599 .

obo:VO_0001035
    obo:IAO_0000115 "a bacterial vaccine against Yersinia ruckeri infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Yersinia ruckeri vaccine" ;
    rdfs:subClassOf obo:VO_0000601, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29486
    ] .

obo:VO_0001036
    obo:IAO_0000112 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/23403993" ;
    obo:IAO_0000115 "a bacterial vaccine vector using a live attenuated Streptococcus gordonii vaccine vector." ;
    obo:IAO_0000117 "Yongqun He, Carly Mantin" ;
    a owl:Class ;
    rdfs:label "Streptococcus gordonii vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 1302" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001037
    obo:IAO_0000112 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/16823926" ;
    obo:IAO_0000115 "a bacterial vaccine vector using a live attenuated Bordetella pertussis BPZE as a vaccine vector." ;
    obo:IAO_0000117 "Yongqun He, Carly Mantin" ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis BPZE vaccine vector" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001038
    obo:IAO_0000112 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/9767712" ;
    obo:IAO_0000115 "a bacterial vaccine vector using the HS93Tox- mutant of the serovar 7 strain of Actinobacillus pleuropneumoniae. This mutant lacks the genes encoding the toxin ApxA and the post-translational activating protein ApxC, but still has genes required for secretion, making it a good vector. " ;
    obo:IAO_0000117 "Yongqun He, Carly Mantin" ;
    a owl:Class ;
    rdfs:label "Actinobacillus pleuropneumoniae HS93Tox vaccine vector" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001039
    obo:IAO_0000115 "an object property that represents an organism has a mutation of a specific gene from the organism genome." ;
    dc:creator "Yongqun He" ;
    a owl:ObjectProperty ;
    rdfs:label "has gene mutation"@en .

obo:VO_0001040
    obo:IAO_0000115 "an Avipox virus vaccine vector that uses a fowlpox virus as the vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng"@en ;
    a owl:Class ;
    rdfs:label "fowlpox virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10261", "pmid: 10729156" ;
    rdfs:subClassOf obo:VO_0001143 .

obo:VO_0001041
    obo:IAO_0000115 """A Listeria monocytogenes vaccine vector that uses the highly attenuated LM1-2 strain
""" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID: 23027427 " ;
    a owl:Class ;
    rdfs:label "L. monocytogenes LM1-2 vaccine vector"@en ;
    rdfs:subClassOf obo:VO_0000068 .

obo:VO_0001042
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "BHV-4 vaccine vector", "bovine herpesvirus 4 vaccine vector" ;
    obo:IAO_0000119 "PMID: 23830977; PMID: 23300989; PMID: 21320537; PMID: 24752229" ;
    a owl:Class ;
    rdfs:label "BoHV-4 vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10385" ;
    rdfs:subClassOf obo:VO_0000283 .

obo:VO_0001043
    obo:IAO_0000115 "an Avipox virus vaccine vector that uses an attenuated canarypox virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "Poulet et al. 2007, PubMed PMID: 17227690.", "WEB: http://en.wikipedia.org/wiki/Canarypox" ;
    a owl:Class ;
    rdfs:label "canarypox vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 44088" ;
    rdfs:subClassOf obo:VO_0001143 .

obo:VO_0001044
    obo:IAO_0000115 "a bacterial vaccine vector that uses an attenuated Vibrio cholerae strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 9529093" ;
    a owl:Class ;
    rdfs:label "Vibrio cholerae vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 666" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001045
    obo:IAO_0000115 "a viral vaccine vector that uses an avian paramyxovirus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "avian paramyxovirus type 3 vaccine vector" ;
    obo:IAO_0000119 "PMID: 21525340" ;
    a owl:Class ;
    rdfs:label "APMV-3 vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 207246" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001046
    obo:IAO_0000115 "a herpesvirus vaccine vector that uses a herpes simplex virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "HSV vaccine vector" ;
    obo:IAO_0000119 "PMID: 22713696; PMID: 19428888; PMID: 20835362; PMID: 16996101" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus vaccine vector"@en ;
    rdfs:subClassOf obo:VO_0000283 .

obo:VO_0001047
    obo:IAO_0000115 "an adenovirus vaccine vector that uses the simian adenovirus ChAd63 strain." ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 22275401; PMID: 23526949; PMID: 22363582" ;
    a owl:Class ;
    rdfs:label "simian adenovirus ChAd63 vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 413684" ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001048
    obo:IAO_0000115 "an orthopoxvirus vaccine vector that uses an attenuated Raccoon poxvirus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 22921740" ;
    a owl:Class ;
    rdfs:label "raccoon poxvirus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10256" ;
    rdfs:subClassOf obo:VO_0001146 .

obo:VO_0001049
    obo:IAO_0000116 "Live temperature-sensitive mutant strain; eye drop administration" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Vaxsafe MS" ;
    rdfs:subClassOf obo:VO_0001077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000861 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001050
    obo:IAO_0000115 "A herpesevirus vaccine vector that uses an established live-virus vaccine against Aujeszky's disease of swine, pseudorabies virus (PrV) strain Bartha (PrV-Ba), to serve as vector." ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "PrV vaccine vector ", "Suid herpesvirus 1 strain Bartha vaccine vector" ;
    obo:IAO_0000119 "PMID: 24431235" ;
    a owl:Class ;
    rdfs:label "pseudorabies virus strain Bartha vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 1006205" ;
    rdfs:subClassOf obo:VO_0000283 .

obo:VO_0001051
    obo:IAO_0000115 "an adenovirus vaccine vector that uses a porcine adenovirus 3 strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "PAV3 vaccine vector" ;
    obo:IAO_0000119 "PMID: 11402666; PMID: 21179494; PMID: 10091994; PMID: 12954206; PMID: 17565687" ;
    a owl:Class ;
    rdfs:label "porcine adenovirus 3 vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 35265" ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001052
    obo:IAO_0000115 "a viral vaccine vector that uses a poliovirus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "PV vaccine vector" ;
    obo:IAO_0000119 "PMID: 19003009; PMID: 12423772; PMID: 17196342" ;
    a owl:Class ;
    rdfs:label "poliovirus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 138950" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001053
    obo:IAO_0000116 "In vitro-cultured supernatant antigens, reduce clinical disease" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Nobivac Piro" ;
    rdfs:subClassOf obo:VO_0001074, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001054
    obo:IAO_0000116 "Live submucosal vaccine; deletions in aroA gene" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Equilis StrepE" ;
    rdfs:subClassOf obo:VO_0000948, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001055
    obo:IAO_0000115 "an adenovirus vaccine vector that uses a chimpanzee adenovirus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    a owl:Class ;
    rdfs:label "chimpanzee adenovirus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 310542" ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001056
    obo:IAO_0000115 "a viral vaccine vector that uses a measles virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "MV vaccine vector" ;
    obo:IAO_0000119 "PMID: 24084235; PMID: 24606680; PMID: 23642239; PMID: 23550539; PMID: 23516477" ;
    a owl:Class ;
    rdfs:label "measles virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11234" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001057
    obo:IAO_0000115 "a viral vaccine vector that uses a Coxsackievirus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 20824074; PMID: 11115722; PMID: 19053211; PMID: 20088713; PMID: 21389776; PMID: 19941986; PMID: 11160741" ;
    a owl:Class ;
    rdfs:label "Coxsackievirus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 12066" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001058
    obo:IAO_0000117 "YH" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Centre for Ticks and Tickborne Disease, Malawi" .

obo:VO_0001059
    obo:IAO_0000115 "a poxvirus vaccine vector that uses an attenuated Oka varicella virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "Human herpesvirus 3 strain Oka vaccine vaccine" ;
    obo:IAO_0000119 "PMID: 10720546; PMID: 16615495; PMID: 18053621" ;
    a owl:Class ;
    rdfs:label "Oka varicella vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 341980" ;
    rdfs:subClassOf obo:VO_0000283 .

obo:VO_0001060
    obo:IAO_0000115 "a viral vaccine vector that uses a NewCastle virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "NDV vaccine vector " ;
    obo:IAO_0000119 "PMID: 23845804" ;
    a owl:Class ;
    rdfs:label "Newcastle disease virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11176" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001061
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Theileria parva vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5875
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5875
    ] .

obo:VO_0001062
    obo:IAO_0000115 "a viral vaccine vector that uses a myxoma virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 10627521; PMID: 12951040; PMID: 14972520; PMID: 8719525; PMID: 12057600; PMID: 18474552; PMID: 21835800; PMID: 22244980" ;
    a owl:Class ;
    rdfs:label "myxoma virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10273" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001063
    obo:IAO_0000115 "a viral vaccine vector that uses a Maraba virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 24322333" ;
    a owl:Class ;
    rdfs:label "Maraba virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 1046251" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001064
    obo:IAO_0000115 "a bacterial vaccine vector that uses an attenuated Mycobacterium smegmatis strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 22546648; PMID: 21900527" ;
    a owl:Class ;
    rdfs:label "Mycobacterium smegmatis vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 1772" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001065
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Neospora caninum vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] .

obo:VO_0001066
    obo:IAO_0000115 "a bacterial vaccine vector that uses an attenuated Lactobacillus gasseri strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 21375708; PMID: 20722604; PMID: 21900526" ;
    a owl:Class ;
    rdfs:label "Lactobacillus gasseri vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 1596" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001067
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "HVT vaccine vector", "Meleagrid herpesvirus 1 vaccine vector" ;
    obo:IAO_0000119 "PMID: 22845318" ;
    a owl:Class ;
    rdfs:label "herpesvirus of turkey vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 37108" ;
    rdfs:subClassOf obo:VO_0000283 .

obo:VO_0001068
    obo:IAO_0000115 "A Herpes simplex virus vaccine vector that uses a virus type 1 strain " ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "HSV-1 vaccine vector" ;
    obo:IAO_0000119 "PMID: 19428888" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus vaccine 1 vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10298" ;
    rdfs:subClassOf obo:VO_0001046 .

obo:VO_0001069
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.immunovaccine.com" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "ImmunoVaccine Technologies, Canada" .

obo:VO_0001070
    obo:IAO_0000115 "a bacterial vaccine vector that uses an E. coli strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 24746937" ;
    a owl:Class ;
    rdfs:label "E. coli vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 562" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001071
    obo:IAO_0000116 "Killed oral vaccine", "Reference: http://www.spaquaculture.com/default.aspx?pageid=553" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "AquaVac Vibrio" ;
    rdfs:subClassOf obo:VO_0000823, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_13489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8015
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001174 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001072
    obo:IAO_0000115 "a viral vaccine vector that uses a duck enteritis virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "Anatid herpesvirus 1 vaccine vector" ;
    obo:IAO_0000119 "PMID: 23267833" ;
    a owl:Class ;
    rdfs:label "duck enteritis virus vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 104388" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001073
    obo:IAO_0000115 "a herpesvirus vaccine vector that uses a CMV virus strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "Cytomegalovirus vaccine vector" ;
    obo:IAO_0000119 "PMID: 23811402" ;
    a owl:Class ;
    rdfs:label "CMV vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10358" ;
    rdfs:subClassOf obo:VO_0000283 .

obo:VO_0001074
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Babesia canis vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5867
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5867
    ] .

obo:VO_0001075
    obo:IAO_0000115 "a bacterial vaccine vector that uses a Salmonella typhi strain" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    a owl:Class ;
    rdfs:label "Salmonella typhi vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 90370" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001076
    obo:IAO_0000115 "a recombinant vector vaccine that uses a homologous vector, i.e., when the target species of the vaccine is a natural host for the vector." ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000119 "WEB: http://www.biosafety.be/GT/Regulatory/Veterinary_vaccines/EMEA_000404en.pdf" ;
    a owl:Class ;
    rdfs:label "recombinant homologous vector vaccine" ;
    rdfs:subClassOf obo:VO_0000484 .

obo:VO_0001077
    obo:IAO_0000115 "a bacterial vaccine against Mycoplasma synoviae infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Mycoplasma synoviae vaccine" ;
    rdfs:subClassOf obo:VO_0000604, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2109
    ] .

obo:VO_0001078
    obo:IAO_0000115 "a recombinant vector vaccine that uses a homologous vector, i.e., when the target species of the vaccine is not one of the natural hosts for the vector." ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000119 "WEB: http://www.biosafety.be/GT/Regulatory/Veterinary_vaccines/EMEA_000404en.pdf" ;
    a owl:Class ;
    rdfs:label "recombinant heterologous vector vaccine" ;
    rdfs:subClassOf obo:VO_0000484 .

obo:VO_0001079
    obo:IAO_0000117 "YH" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Local veterinary institutes" .

obo:VO_0001080
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Androstenedione" ;
    rdfs:subClassOf obo:FMA_12278 .

obo:VO_0001081
    obo:IAO_0000115 "an adenovirus vaccine vector that uses an Adenovirus serotype 5 strain." ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000118 "human adenovirus 5 vaccine vector" ;
    a owl:Class ;
    rdfs:label "adenovirus serotype 5 vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 28285" ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001082
    obo:IAO_0000115 "an adenovirus vaccine vector that contains a deletion of the gp64 gene. As a result of the deletion, this vector is unable to propagate infection from cell to cell, and this defect results from both a severe reduction in the production of budded virions and the absence of GP64 on virions. " ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000119 "PMID: 17989172" ;
    a owl:Class ;
    rdfs:label "AcMNPV vector", "autographa californica multicapsid Nucleopolyhedrovirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 46015" ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001083
    obo:IAO_0000115 "protozoan vaccine that is used to protect against Giardia intestinalis infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Giardia duodenalis vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5741
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5741
    ] .

obo:VO_0001084
    obo:IAO_0000115 "a viral vaccine vector that uses a baculovirus as the vector " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID: 22705893" ;
    a owl:Class ;
    rdfs:label "baculovirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10469" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001085
    obo:IAO_0000115 "a Chlamydia bacterial vaccine against C. abortus infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Chlamydophila abortus vaccine" ;
    rdfs:subClassOf obo:VO_0000573, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83555
    ] .

obo:VO_0001086
    obo:IAO_0000115 "an adenovirus vaccine vector that uses a complex adenovirus as the vector strain." ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000118 "CAdVax vaccine vector" ;
    obo:IAO_0000119 "PMID: 19776190; PMID: 18480438; PMID: 17634508; PMID: 18216185; PMID: 16501083" ;
    a owl:Class ;
    rdfs:label "complex adenovirus vaccine vector" ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001087
    obo:IAO_0000115 "an adenovirus vaccine vector that uses a human adenovirus as the vector strain." ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000118 "HAd vaccine vector" ;
    obo:IAO_0000119 "PMID: 16297508; PMID: 15761255" ;
    a owl:Class ;
    rdfs:label "human adenovirus vaccine vector" ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001088
    obo:IAO_0000115 "a viral vaccine vector that uses a murine leukemia virus as the vaccine vector" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Murine_leukemia_virus" ;
    a owl:Class ;
    rdfs:label "murine leukemia viral vector vaccine" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11786" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001089
    obo:IAO_0000117 "YH, XZ" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm" ;
    a owl:Class ;
    rdfs:label "CDC recommendation of the use of  Influenza A (h1N1) 2009 vaccine" ;
    rdfs:subClassOf obo:IAO_0000001 .

obo:VO_0001090
    obo:IAO_0000115 "a population group that have priority for  vaccination when a vaccine is first available." ;
    obo:IAO_0000117 "YH,  XZ" ;
    obo:IAO_0000118 "vaccination target group" ;
    a owl:Class ;
    rdfs:label "vaccinee priority group" ;
    rdfs:subClassOf obo:VO_0000546 .

obo:VO_0001091
    obo:IAO_0000116 "Chimera H5N3 virus, inactivated in oil-based adjuvant" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Poulvac FluFend I AI H5N3 RG" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000205 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001092
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "USDA" ;
    rdfs:subClassOf obo:OBI_0000450 .

obo:VO_0001093
    obo:IAO_0000115 "a vaccinia vaccine vector that uses the highly attenuated NYVAC  as vector" ;
    obo:IAO_0000116 "A highly attenuated vaccinia virus strain, NYVAC (vP866), was derived from a plaque-cloned isolate of the Copenhagen vaccine strain by the precise deletion of 18 open reading frames (ORFs) from the viral genome. Source: http://www.ncbi.nlm.nih.gov/pubmed/1566575" ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000119 "PMID: 22930439;; PMID: 24069354; PMID: 1566575" ;
    a owl:Class ;
    rdfs:label "NYVAC vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10249 (for Vaccinia virus Copenhagen)" ;
    rdfs:subClassOf obo:VO_0000600 .

obo:VO_0001094
    obo:IAO_0000117 "XY, XZ" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm" ;
    a owl:Class ;
    rdfs:label "pregnant women" ;
    rdfs:subClassOf obo:OBI_0000181 .

obo:VO_0001095
    obo:IAO_0000115 "passive immunization by injecting a recipient with pre-made antibody, antitoxin, epitope, etc."@en ;
    dc:creator "YL"@en ;
    a owl:Class ;
    rdfs:label "passive immunization by injecting pre-made immune element" ;
    rdfs:subClassOf obo:VO_0000492 .

obo:VO_0001096
    obo:IAO_0000115 "A vaccine used to increase the fecundity in breeding ewes. Ovastim increases the number of multiple ovulations and therefore the number of multiple births." ;
    obo:IAO_0000116 "Increased ovulation/twinning" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.virbac.co.nz/p-virbacnzpuben/display.aspx?srv=p-virbacnz&typ=pub&lang=en&cmd=view&style=styles/specie.xsl&select=PRODUCT[@ID$eq$PRODUCT_264]&affp=&" ;
    a owl:Class ;
    rdfs:label "Ovastim" ;
    rdfs:subClassOf obo:VO_0000372, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001080
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000914 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001097
    obo:IAO_0000116 "Canarypox virus-vectored vaccine (HA and F antigens)" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "RECOMBITEK rDistemper" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001098
    obo:IAO_0000117 "XY, XZ" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm" ;
    a owl:Class ;
    rdfs:label "persons  living with or providing care for infants aged <6 months" ;
    rdfs:subClassOf obo:OBI_0000181 .

obo:VO_0001099
    obo:IAO_0000117 "XY, XZ" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm" ;
    a owl:Class ;
    rdfs:label "health-care and emergency medical services personnel" ;
    rdfs:subClassOf obo:OBI_0000181 .

obo:VO_0001100
    obo:IAO_0000117 "XY, XZ" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm" ;
    a owl:Class ;
    rdfs:label "persons aged 6 months--24 years" ;
    rdfs:subClassOf obo:OBI_0000181 .

obo:VO_0001101
    obo:IAO_0000117 "XY, XZ" ;
    obo:IAO_0000119 "WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm" ;
    a owl:Class ;
    rdfs:label "persons aged 25--64 years with  medical conditions at higher risk for influenza-related complications" ;
    rdfs:subClassOf obo:OBI_0000181 .

obo:VO_0001102
    obo:IAO_0000115 "a viral vaccine vector that uses a retroviral strain" ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000119 "PMID: 2839718" ;
    a owl:Class ;
    rdfs:label "retroviral vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11632", "Vaxvec: 23" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001103
    obo:IAO_0000117 "YH, MC, and XZ", "inactivation is a processual entity that produces inactive material." ;
    a owl:Class ;
    rdfs:label "inactivation" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0001104
    obo:IAO_0000117 "Yongqun He", "a retroviral vaccine vector where a Rous sarcoma virus (a retrovirus) is used" ;
    a owl:Class ;
    rdfs:label "Rous sarcoma virus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11886", "Vaxvec: 20" ;
    rdfs:subClassOf obo:VO_0001102 .

obo:VO_0001105
    obo:IAO_0000115 "a bacterial vaccine against Lawsonia intracellularis infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Lawsonia intracellularis vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29546
    ] .

obo:VO_0001106
    obo:IAO_0000115 "a poxvirus vaccine vector that uses a swinepox virus as the vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng"@en ;
    a owl:Class ;
    rdfs:label "swinepox virus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10276", "PMID: 22515033; PMID: 21807055; PMID: 22884664; PMID: 23135159" ;
    rdfs:subClassOf obo:VO_0000447 .

obo:VO_0001107
    obo:IAO_0000115 "a vaccinia virus vector that uses the Modified Vaccinia Ankara (MVA) virus. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID: 24933081" ;
    a owl:Class ;
    rdfs:label "Modified Vaccinia Ankara (MVA) virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 467144" ;
    rdfs:subClassOf obo:VO_0000600 .

obo:VO_0001108
    obo:IAO_0000115 "a poxvirus vaccine vector that uses an ORF virus which is a parapoxvirus." ;
    obo:IAO_0000117 "Shunzhou Deng, Yongqun He" ;
    a owl:Class ;
    rdfs:label "ORF virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10258" ;
    rdfs:subClassOf obo:VO_0000447 .

obo:VO_0001109
    obo:IAO_0000115 "a vaccinia virus vector that uses the MVTT vaccine strain as the vector. MVTT is an attenuated vaccine strain. " ;
    obo:IAO_0000117 "Shunzhou Deng, Yongqun He" ;
    obo:IAO_0000118 "vaccinia virus TianTan vaccine vector" ;
    a owl:Class ;
    rdfs:label "MVTT vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10253" ;
    rdfs:subClassOf obo:VO_0000600 .

obo:VO_0001110
    obo:IAO_0000115 "a fertility vaccine that enhance fertility in sheep." ;
    obo:IAO_0000116 "Linked to human serum albumin; increased ovulation/twinning", "withdrawn" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.journals.elsevierhealth.com/periodicals/anirep/article/PII0378432093901125/abstract" ;
    a owl:Class ;
    rdfs:label "Fecundin" ;
    rdfs:subClassOf obo:VO_0000372, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001080
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001212 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001111
    obo:IAO_0000115 "A poxvirus vaccine vector that uses an attenuated lumpy skin disease virus as the vector.  " ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "LSDV vaccine vector" ;
    a owl:Class ;
    rdfs:label "lumpy skin disease virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 59509" ;
    rdfs:subClassOf obo:VO_0001115 .

obo:VO_0001112
    obo:IAO_0000115 "a viral vaccine vector that uses a bovine parainfluenza virus strain as vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000119 "PMID: 22570186; PMID: 24478424." ;
    a owl:Class ;
    rdfs:label "bovine parainfluenza virus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11215" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001113
    obo:IAO_0000116 "Gametocyte antigen(s); transmission blocking through maternal antibody transfer" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "CoxAbic" ;
    rdfs:subClassOf obo:VO_0001125, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000964 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001114
    obo:IAO_0000115 "a Bordetella bacterial vaccine against infection of B. avium" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Bordetella avium vaccine" ;
    rdfs:subClassOf obo:VO_0000587, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_521
    ] .

obo:VO_0001115
    obo:IAO_0000115 "a poxvirus vaccine vector that uses an attenuated capripoxvirus strain as the vaccine vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    a owl:Class ;
    rdfs:label "capripoxvirus vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10265" ;
    rdfs:subClassOf obo:VO_0000447 .

obo:VO_0001116
    obo:IAO_0000115 "survival of live vaccine inside host is a processual entity that represents the survival of a live vaccine inside its host. The time of the survival is often important for the success of the live vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "survival of live vaccine inside host" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0001117
    obo:IAO_0000115 "persistence of vaccine induced immune response is a processual entity that indicates the persistence of an immune reponse induced by a vaccine in a vaccinated host." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "persistence of vaccine induced immune response" ;
    rdfs:subClassOf obo:BFO_0000015 .

obo:VO_0001118
    obo:IAO_0000115 "a bacterial vaccine vector that uses a Corynebacterium pseudotuberculosis strain as the vaccine vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    a owl:Class ;
    rdfs:label "Corynebacterium pseudotuberculosis vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 1719" ;
    rdfs:subClassOf obo:VO_0000166 .

obo:VO_0001119
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.merial.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Merial, Inc"^^xsd:string .

obo:VO_0001120
    obo:IAO_0000116 "Killed tachyzoites, reduces abortion" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Bovilis Neoguard" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001121
    obo:IAO_0000115 "a viral vaccine vector that uses a rhabdovirus-based viral strain as the vaccine vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    a owl:Class ;
    rdfs:label "rhabdovirus-based vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11270" ;
    rdfs:subClassOf obo:VO_0000610 .

obo:VO_0001122
    obo:IAO_0000115 "a recombinant vaccine vector that uses Saccharomyces cerevisiae as the vaccine vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    a owl:Class ;
    rdfs:label "Saccharomyces cerevisiae vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 4932" ;
    rdfs:subClassOf obo:VO_0001141 .

obo:VO_0001123
    obo:IAO_0000116 "Modified live virus" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "RECOMBITEK Canine Parvo" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001124
    obo:IAO_0000115 "a viral vaccine vector that uses a Venezuelan equine encephalitis virus strain as the vaccine vector" ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "Venezuelan equine encephalitis virus vaccine vector"@en ;
    a owl:Class ;
    rdfs:label "VEE vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 11036" ;
    rdfs:subClassOf obo:VO_0000144 .

obo:VO_0001125
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Eimeria maxima vaccine" ;
    rdfs:subClassOf obo:VO_0000906 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000906
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_5804
            ]
        )
    ] .

obo:VO_0001126
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm192126.htm"^^xsd:anyURI ;
    obo:VO_0003099 "Agriflu"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza Virus Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Novartis Vaccines and Diagnostics Inc."^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization of adults 18 years of age and older against influenza disease caused by influenza virus subtypes A and type B present in the vaccine."^^xsd:anyURI ;
    obo:VO_0003162 "BL 125297/32"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Agriflu" ;
    rdfs:seeAlso "CVX: 140" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000971 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001127
    obo:IAO_0000115 "live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated Brucella vaccine" ;
    rdfs:seeAlso "CVX: 135" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000025
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001014
            ]
        )
    ] .

obo:VO_0001128
    obo:IAO_0000115 "a canarypox vaccine vector that uses an attenuated canarypox virus strain ALVAC. The ALVAC vector is a canarypox virus clone obtained after four rounds of plaque purification of a strain from a vaccine for canaries. " ;
    obo:IAO_0000117 "Yongqun He, Shunzhou Deng" ;
    obo:IAO_0000118 "ALVAC" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/17227690" ;
    a owl:Class ;
    rdfs:label "ALVAC vaccine vector"@en ;
    rdfs:subClassOf obo:VO_0001043 .

obo:VO_0001129
    obo:IAO_0000115 "an adenovirus vaccine vector that is not able to replicate." ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "non-replicating adenovirus accine vector"@en ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001130
    obo:IAO_0000115 "a bacterial vaccine against A. pleuropneumoniae infection" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Actinobacillus pleuropneumoniae vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_715
    ] .

obo:VO_0001131
    obo:IAO_0000115 "an adenovirus vaccine vector that is able to replicate." ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "replicating adenovirus accine vector"@en ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0001132
    obo:IAO_0000115 "assay of CFU reduction in liver is a CFU reduction assay that is measured using the extracted liver as the tissue for isolation of infected pathogens." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "assay of CFU reduction in liver" ;
    rdfs:subClassOf obo:VO_0000242 .

obo:VO_0001133
    obo:IAO_0000115 "assay of CFU reduction in lung is a CFU reduction assay that is measured using the extracted lung as the tissue for isolation of infected pathogens." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "assay of CFU reduction in lung" ;
    rdfs:subClassOf obo:VO_0000242 .

obo:VO_0001134
    obo:IAO_0000115 "live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella abortus infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated Brucella abortus vaccine" ;
    rdfs:subClassOf obo:VO_0000108 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000108
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001014
            ]
        )
    ] .

obo:VO_0001135
    obo:IAO_0000115 "live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella melitensis infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated Brucella melitensis vaccine" ;
    rdfs:subClassOf obo:VO_0000709 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000709
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001014
            ]
        )
    ] .

obo:VO_0001136
    obo:IAO_0000115 "live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella melitensis infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated Brucella suis vaccine" ;
    rdfs:subClassOf obo:VO_0000721, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000721
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001014
            ]
        )
    ] .

obo:VO_0001137
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Eimeria tenella vaccine" ;
    rdfs:subClassOf obo:VO_0000906 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000906
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_5802
            ]
        )
    ] .

obo:VO_0001138
    obo:IAO_0000116 "S48 strain with a lost ability to form cysts after passages in mice" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Ovilis Toxovax" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001139
    obo:IAO_0000115 "vaccine viability is a viability of a vaccine organism." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "vaccine organism viability" ;
    rdfs:subClassOf obo:PATO_0000169 .

obo:VO_0001140
    obo:IAO_0000116 "DNA vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "West Nile-Innovator DNA" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000205 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001141
    obo:IAO_0000115 "a recombinant vaccine vector that uses a fungus as the vaccine vector" ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "fungal vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 4751" ;
    rdfs:subClassOf obo:VO_0000599 .

obo:VO_0001142
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Leishmania donovani vaccine" ;
    rdfs:subClassOf obo:VO_0000762 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000762
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_5661
            ]
        )
    ] .

obo:VO_0001143
    obo:IAO_0000115 "a poxvirus vaccine vector that uses an avipox virus as the vector" ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "Avipox virus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10260" ;
    rdfs:subClassOf obo:VO_0000447 .

obo:VO_0001144
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "pCIBLSOmp31" ;
    a owl:Class ;
    rdfs:label "Brucella DNA vaccine encoding chimera BLSOmp31" ;
    rdfs:seeAlso "PMID: 17600596" ;
    rdfs:subClassOf obo:VO_0001226 .

obo:VO_0001145
    obo:IAO_0000117 "YH, ZX", "vaccine being viable is a vaccine viability that indicates a vaccine uses live organism." ;
    a owl:Class ;
    rdfs:label "vaccine organism live" ;
    rdfs:subClassOf obo:VO_0001139 .

obo:VO_0001146
    obo:IAO_0000115 "a poxvirus vaccine vector that uses an orthopox virus as the vector" ;
    obo:IAO_0000117 "Yongqun He" ;
    a owl:Class ;
    rdfs:label "Orthopoxvirus vaccine vector" ;
    rdfs:seeAlso "NCBI Taxonomy ID: 10242" ;
    rdfs:subClassOf obo:VO_0000447 .

obo:VO_0001147
    obo:IAO_0000115 "a cytokine vaccine adjuvant that includes IL-12." ;
    obo:IAO_0000117 "IL-12 vaccine adjuvant is a vaccine adjuvant that contains IL-12.", "YH, ZX" ;
    a owl:Class ;
    rdfs:label "IL-12 vacince adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001148
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "no vaccine protection" ;
    rdfs:subClassOf obo:VO_0000247 .

obo:VO_0001149
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "significant vaccine protection" ;
    rdfs:subClassOf obo:VO_0000247 .

obo:VO_0001150
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "enhanced significant protection" ;
    rdfs:subClassOf obo:VO_0000247 .

obo:VO_0001151
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Piscirickettsia salmonis infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Piscirickettsia salmonis vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1238
    ] .

obo:VO_0001152
    obo:IAO_0000115 "An E. coli vaccine against enterotoxigenic E. coli infections" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "ETEC vaccine" ;
    a owl:Class ;
    rdfs:label "enterotoxigenic E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0001153
    obo:IAO_0000116 "Increased ovulation/twinning" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Androvax" ;
    rdfs:subClassOf obo:VO_0000372, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001080
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001154
    obo:IAO_0000115 "B. abortus L7/L12 is a B. abortus subunit vaccine using L7/L12 that is formed by recombinant Human Serum Albumin (HAS)-L7/L12 fusion protein." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "Brucella abortus Human serum albumin (HAS)-L7/L12" ;
    obo:IAO_0000119 "PMID: 19293473" ;
    a owl:Class ;
    rdfs:label "B. abortus HSA-L7/L12" ;
    rdfs:subClassOf obo:VO_0000323 .

obo:VO_0001155
    obo:IAO_0000115 "An E. coli vaccine against Shiga toxin-producing E. coli (STEC) infections" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "STEC vaccine" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238053/" ;
    a owl:Class ;
    rdfs:label "Shiga toxin-producing E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0001156
    obo:IAO_0000116 "a vaccine against avian pathogenic Escherichia coli (APEC) infection, a major problem for the poultry industry in the world." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "APEC vaccine" ;
    a owl:Class ;
    rdfs:label "avian pathogenic E. coli vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0001157
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "an E. coli vaccine against O157 E. coli strain infections" ;
    a owl:Class ;
    rdfs:label "E. coli O157 vaccine"@en ;
    rdfs:subClassOf obo:VO_0000041 .

obo:VO_0001158
    obo:IAO_0000116 "Extracted ApxI, ApxII, ApxIII, and outer membrane proteins" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Porcilis APP" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001159
    obo:IAO_0000115 "PUREVAX Ferret Distemper is a lyophilized ferret vaccine of a recombinant canarypox vector expressing the HA and F glycoproteins of canine distemper virus. Reference: http://www.drugs.com/vet/purevax-ferret-distemper.html." ;
    obo:IAO_0000116 "Canarypox virus-vectored vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "PUREVAX Ferret Distemper" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9669
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001160
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "vaccination dose specification" ;
    rdfs:subClassOf obo:OBI_0000969, [
        a owl:Restriction ;
        owl:onProperty obo:IAO_0000136 ;
        owl:someValuesFrom obo:VO_0000002
    ] .

obo:VO_0001161
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "challenge dose specification" ;
    rdfs:subClassOf obo:OBI_0000969, [
        a owl:Restriction ;
        owl:onProperty obo:IAO_0000136 ;
        owl:someValuesFrom obo:OBI_0000712
    ] .

obo:VO_0001162
    obo:IAO_0000115 "specification of time interval after vaccination for challenge is a plan specification that specifies the time interval after vacciation for challenge" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "specification of vaccination-challenge interval" ;
    rdfs:subClassOf obo:IAO_0000104 .

obo:VO_0001163
    obo:IAO_0000115 "pathogen challenge protocol is a protocol that is used for a pathogen challenge process." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "pathogen challenge protocol" ;
    rdfs:subClassOf obo:OBI_0000272 .

obo:VO_0001164
    obo:IAO_0000115 "reduction of colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. It equals to a reduction of a CFU count from another CFU count. This term is often used as a measurement of a vaccine protection study." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "reduction of colony forming unit" ;
    rdfs:subClassOf obo:VO_0000555 .

obo:VO_0001165
    obo:IAO_0000115 "intraperitoneal pathogen challenge is a pathogen challenge process that occurs in the intraperitoneal site of a host." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "intraperitoneal pathogen challenge" ;
    rdfs:subClassOf obo:OBI_0000712 .

obo:VO_0001166
    obo:IAO_0000115 "a vaccination process that occurs in the intraperitoneal route" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "intraperitoneal vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000344
    ] .

obo:VO_0001167
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "KLH-s-FimH1-25 with CFA and then IFA"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 4329" ;
    rdfs:subClassOf obo:VO_0000628 .

obo:VO_0001168
    obo:IAO_0000115 "an E. coli subunit vaccine that uses E. coli FimH adhesin protein as teh antigen, and uses the complete Freund's adjuvant (CFA) in the first vaccination and the incomplete Freund's adjuvant (IFA) in the boost vaccination." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PubMed: http://www.ncbi.nlm.nih.gov/pubmed/9110982" ;
    a owl:Class ;
    rdfs:label "E. coli FimH with CFA and then IFA"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 4330" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010987
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:VO_0000139
                obo:VO_0000142
            )
        ]
    ] .

obo:VO_0001169
    obo:IAO_0000115 "E. coli DNA vaccine is a DNA vaccine that protects against an E. coli infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "E. coli DNA vaccine" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000041
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000623
            ]
        )
    ] .

obo:VO_0001170
    obo:IAO_0000115 "a vaccine organism that is a specific strain" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine strain"@en ;
    rdfs:subClassOf obo:VO_0000506, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001182
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001182
    ] .

obo:VO_0001171
    obo:IAO_0000115 "B. melitensis bp26 and omp31 deletion vaccine is a Brucella melitensis vaccine that has double deletions of bp26 and omp31." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "CGV2631" ;
    obo:IAO_0000119 "PMID: 17070627" ;
    a owl:Class ;
    rdfs:label "B. melitensis Rev. 1 with bp26 and omp31 deletions" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_29459
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom [
                        a owl:Class ;
                        owl:intersectionOf (obo:VO_0002561
                            obo:VO_0002567
                        )
                    ]
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ] .

obo:VO_0001172
    obo:IAO_0000117 "YH", "pCIOmp31 is a B. melitensis DNA vaccine expressing Omp31 that uses the pCI plasmid." ;
    obo:IAO_0000119 "PMID: 16177328" ;
    a owl:Class ;
    rdfs:label "pCIOmp31" ;
    rdfs:subClassOf obo:VO_0000325 .

obo:VO_0001173
    obo:IAO_0000117 "YH", "pTargeTomp31 is a B. melitensis DNA vaccine expressing Omp31  that uses the pTargeT mammalian expression system vector (Promega, USA)." ;
    obo:IAO_0000119 "PMID: 17014873" ;
    a owl:Class ;
    rdfs:label "pTargeTomp31" ;
    rdfs:subClassOf obo:VO_0000325 .

obo:VO_0001174
    obo:IAO_0000116 "Intervet has merged with Schering-Plough Animal Health  and become Intervet/Schering-Plough Animal Health™ (YL.)"@en ;
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.intervet.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Schering-Plough Animal Health" .

obo:VO_0001175
    obo:IAO_0000115 "B. abortus L7/L12 fused to MBP is a B. abortus subunit vaccine using L7/L12 that uses recombinant L7/L12 fused on maltose binding protein MBP." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID: 8873388" ;
    a owl:Class ;
    rdfs:label "B. abortus L7/L12 fused to MBP" ;
    rdfs:subClassOf obo:VO_0000323 .

obo:VO_0001176
    obo:IAO_0000115 "inactivated influenza vaccine is an inactivated viral vaccine that targets at influenza viral infections." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "inactivated influenza vaccine" ;
    rdfs:subClassOf obo:VO_0000642 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000642
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0000211
            ]
        )
    ] .

obo:VO_0001177
    obo:IAO_0000116 "Precocious and egg-passaged lines" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Livacox" ;
    rdfs:subClassOf obo:VO_0001137, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000846 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001178
    obo:IAO_0000115 "live attenuated influenza vaccine is a live attenuated vaccine that protects against influenza viral infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated influenza vaccine" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000642
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001015
            ]
        )
    ] .

obo:VO_0001179
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.bayer.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Bayer Leverkusen" .

obo:VO_0001180
    a owl:Class ;
    rdfs:label "laboratory test" ;
    rdfs:subClassOf obo:OBI_0000011 .

obo:VO_0001181
    obo:IAO_0000116 "Live temperature-sensitive mutant strain; eye drop administration" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Vaxsafe MG" ;
    rdfs:subClassOf obo:VO_0000949, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000861 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001182
    obo:IAO_0000115 "a vaccine role that is borne by an organism strain serving as a vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine strain role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0001183
    obo:IAO_0000116 "Peptide conjugated to keyhole limpet hemocyanin in mycobacterium-oil adjuvant (AdjuVac); contraceptive vaccine to control wildlife", "registration reported to be in progress" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.aphis.usda.gov/wildlife_damage/nwrc/research/reproductive_control/gonacon.shtml", "a contraceptive vaccine that is used in wildlife population" ;
    a owl:Class ;
    rdfs:label "GonaCon" ;
    rdfs:subClassOf obo:VO_0000759, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000972
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000304 ;
        owl:someValuesFrom obo:VO_0001092
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9850
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9900
    ] .

obo:VO_0001184
    a owl:Class ;
    rdfs:label "vaccine protection ANOVA" ;
    rdfs:subClassOf obo:OBI_0200201 .

obo:VO_0001185
    obo:IAO_0000116 "In ovo delivery using proprietary platform injection system" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Inovocox" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000959 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001186
    obo:IAO_0000115 "A data set that represents a set of data for a list of variables (e.g., vaccination dose) for the data analysis of an vaccine investigation study." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccine investigation data set" ;
    rdfs:subClassOf obo:IAO_0000100, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001188
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001189
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001190
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001191
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001192
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001193
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001194
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001195
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001196
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001197
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001198
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001202
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001203
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001204
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001205
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001206
    ] .

obo:VO_0001187
    obo:IAO_0000115 "a vaccination that occurs in the intramuscular route." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "intramuscular vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000340
    ] .

obo:VO_0001188
    obo:IAO_0000115 "a measurement datum that represents a vaccine strain. Different strains can be represented using distinct digital numbers. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccine strain datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001189
    obo:IAO_0000115 "a measurement datum that represents vaccine viability. 0 = live; 1 = irradiated; 2 = killed." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccine viability datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001190
    obo:IAO_0000115 "a measurement datum that indicates the usage of a vaccine adjuvant. Different digital numbers can be used to represent different adjuvants. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccine adjuvant usage datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001191
    obo:IAO_0000115 "a measurement datum that represents a specific protective antigen used in a vaccine. The antigen can be represented by a described digit. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccine protective antigen datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001192
    obo:IAO_0000115 "a measurement datum that represents a specific mutated gene from a vaccine strain. The mutated can be represented by a described digit. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "mutated gene in vaccine strain datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001193
    obo:IAO_0000115 """a measurement datum that represents a specific mouse strain used for vaccination. Different strains can be represented using discretized digitals.  For example, 0 = BALB/c; 1 = CD1; 2 = mixed/outbred; 3 = C57BL/6; 4 = OF1; 5 = 129/Sv; 6 = Swiss albino.
""" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccination mouse strain datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001194
    obo:IAO_0000115 "A measurement datum that represents the biological sex of an animal. The result can be represented using a discretized digit, for example, 0 = female; 1 = male." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "biological sex datum" ;
    rdfs:subClassOf obo:IAO_0000109, [
        a owl:Restriction ;
        owl:onProperty obo:IAO_0000136 ;
        owl:someValuesFrom obo:PATO_0000047
    ] .

obo:VO_0001195
    obo:IAO_0000115 """a measurement datum that represents a specific route (e.g., i.p.) used for vaccination. Different routes can be represented using discretized digitals.  0 = IP; 1 = PO; 2 = SC; 3 = IM; 4 = IN; 6 = IG; 7 = IV; 8 = ID.

""" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccination route datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001196
    obo:IAO_0000115 "a vaccination dose that is used with the unit of colony forming units (CFU)." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccination dose (unit: CFU)" ;
    rdfs:subClassOf obo:VO_0000814 .

obo:VO_0001197
    obo:IAO_0000115 "A measurement datum that represents the animal age (unit: day) at the time of vaccination." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "animal age at vaccination in days" ;
    rdfs:subClassOf obo:VO_0004926 .

obo:VO_0001198
    obo:IAO_0000115 "a measurement datum that represents a specific pathogen strain used for animal challenge study. Different pathogen strains can be represented using discretized digitals.  " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "pathogen strain for challenge datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001199
    obo:IAO_0000115 "a measurement datum that represents a specific pathogen used for animal challenge study. Different pathogens can be represented using discretized digitals.  " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "pathogen challenge datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001200
    obo:IAO_0000116 "Native fucose-mannose-ligand antigen complex" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Leishmune" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9615
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000205 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001201
    obo:IAO_0000116 "Live oral vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Enterisol Ileitis" ;
    rdfs:subClassOf obo:VO_0001105, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001202
    obo:IAO_0000115 "a challenge dose that is represented with the unit of colony forming units (CFU)." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "challenge dose (unit: CFU)" ;
    rdfs:subClassOf obo:VO_0000900 .

obo:VO_0001203
    obo:IAO_0000115 "a measurement datum that represents a length of days as the interval between a vaccination and a challenge in a specific vaccine protection study. " ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccination-challenge interval in days" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001204
    obo:IAO_0000115 "A colony forming unit (CFU) from the sample of mouse spleen." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "CFU per spleen" ;
    rdfs:subClassOf obo:VO_0000189 .

obo:VO_0001205
    obo:IAO_0000115 "a reduction of CFU that was measured with the unit of colony forming units (CFU) from the sample of mouse spleen." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "CFU reduction per spleen" ;
    rdfs:subClassOf obo:VO_0001164 .

obo:VO_0001206
    obo:IAO_0000115 "a measurement datum that represents a type of vaccine protection efficacy as an outcome of a vaccine protection study. The result can be represented as a digit, for example, 0 = no protection, and 1 = protection (determined by a p-value cutoff)." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "He Y, Xiang Z, Todd T, Courtot M, Brinkman R, Zheng J, Stoeckert CJ, Malone J, Rocca-Serra P, Sansone S, Fostel J, Soldatova LN, Peters B, Rutternberg A. Ontology representation and ANOVA analysis of vaccine protection investigation. Proceeding of Bio-Ontologies 2010: Semantic Applications in Life Sciences, ISMB, July 9-10, 2010. Boston, MA, USA. Full length paper. URL: http://www.hegroup.org/docs/ANOVA_Vaccine_usecase_camera.pdf", "Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026. " ;
    a owl:Class ;
    rdfs:label "vaccine protection efficacy datum" ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0001207
    obo:IAO_0000115 "A Chlamydia bacterial vaccine against Chlamydia trachomatis infection" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Chlamydia trachomatis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000573, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_813
    ] .

obo:VO_0001208
    obo:IAO_0000115 "B. abortus BLS-L7/L12 is a B. abortus subunit vaccine using L7/L12 that is made as a recombinant BLS-L7/L12 fusion protein vaccine." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "recombinant Brucella BLS-L7/L12 fusion protein vaccine", "recombinant Brucella lumazine synthase and L7/L12 fusion protein vaccine" ;
    obo:IAO_0000119 "PMID: 19596411" ;
    a owl:Class ;
    rdfs:label "B. abortus BLS-L7/L12" ;
    rdfs:subClassOf obo:VO_0000323 .

obo:VO_0001209
    obo:IAO_0000115 "vaccine protection efficacy measurement is an assay that measures the protection efficayc of a vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine protection efficacy measurement" ;
    rdfs:subClassOf obo:OBI_0000070 .

obo:VO_0001210
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "a subunit vaccien that uses LPS as protective antigen" ;
    a owl:Class ;
    rdfs:label "lipopolysaccharide subunit vaccine" ;
    rdfs:subClassOf obo:VO_0000534 .

obo:VO_0001211
    obo:IAO_0000115 "viral vaccine that is used to protect against African swine fever virus infection" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "African swine fever virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10497
    ] .

obo:VO_0001212
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.coopersanimalhealth.com.au/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Coopers Animal Health" .

obo:VO_0001213
    obo:IAO_0000115 "A viral vaccine that protects against infection with Foot-and-mouth disease virus." ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Foot-and-mouth disease virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12092
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12110
    ] .

obo:VO_0001214
    obo:IAO_0000115 "a bacterial vaccine that uses inactivated bacterial organism. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "inactivated bacterial vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000165
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0000211
            ]
        )
    ] .

obo:VO_0001215
    obo:IAO_0000115 "an anti-reproductive vaccine for cattle. The vaccine is based on the established principle that antibodies to the hypothalamic releasing hormone, gonadotrophin releasing hormone (GnRH) block the action of GnRH on pituitary secretion of luteinizing hormone and follicle stimulating hormone, leading to gonadal atrophy in mammals. The vaccine comprises an immunogenic GnRH:ovalbumin conjugate formulated in a novel double adjuvant system and is administered in a two-dose treatment regimen. " ;
    obo:IAO_0000116 "LHRH peptide conjugated to ovalbumin; oil emulsion adjuvant", "withdrawn in 1996" ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://www.ncbi.nlm.nih.gov/pubmed/1370000" ;
    a owl:Class ;
    rdfs:label "Vaxstrate" ;
    rdfs:subClassOf obo:VO_0000759, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000972
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000877 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001216
    obo:IAO_0000115 "A viral vaccine that protects against infection with Lymphocytic choriomeningitis mammarenavirus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Lymphocytic choriomeningitis mammarenavirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11623
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11623
    ] .

obo:VO_0001217
    obo:IAO_0000115 "a bacterial vaccine that is live and attenuated" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "live attenuated bacterial vaccine" ;
    rdfs:subClassOf obo:VO_0000165 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000165
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001014
            ]
        )
    ] .

obo:VO_0001218
    obo:IAO_0000115 "Veterinary vaccine is a vaccine that is used for animals (excluding humans), for example, pet, domestic, wildlife, and livestock animals." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "veterinary vaccine" ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0001219
    obo:IAO_0000117 "YH" ;
    oboInOwl:hasURI "http://www.dowagro.com/homepage/index.htm?DCSext.das=dowagro.com" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Dow AgroSciences" .

obo:VO_0001220
    obo:IAO_0000115 "a viral vaccine that is live attenuated" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment """This term has an equivalent class:
'viral vaccine' and ('has quality at some time' some 'vaccine organism live attenuated')

However, running the reasoner takes time. As a way to reducing the time, I have tentatively made tern two subclasses instead of equivalent class. If needed, the equivalent class can be used in SPARQL or converted back in VO. --Oliver
""" ;
    rdfs:label "live attenuated viral vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000086 ;
                owl:someValuesFrom obo:VO_0001015
            ]
        )
    ] .

obo:VO_0001221
    obo:IAO_0000117 "YH", "a B. abortus vaccine that uses subunit antigen" ;
    a owl:Class ;
    rdfs:label "Brucella abortus subunit vaccine" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ] .

obo:VO_0001222
    obo:IAO_0000115 "A viral vaccine that protects aganist Newcastle disease virus infection." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Newcastle disease virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11176
            ]
        )
    ] .

obo:VO_0001223
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis subunit vaccine" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ] .

obo:VO_0001224
    obo:IAO_0000115 "A viral vaccine that protects against infection with Viral hemorrhagic septicemia virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Viral hemorrhagic septicemia virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11287
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11287
    ] .

obo:VO_0001225
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus DNA vaccine" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000623
    ] .

obo:VO_0001226
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis DNA vaccine" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000623
    ] .

obo:VO_0001227
    obo:IAO_0000115 "A viral vaccine that protects against infection with Human herpesvirus 5." ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Human betaherpesvirus 5 vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10359
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10359
    ] .

obo:VO_0001228
    obo:IAO_0000115 "A viral vaccine that protects against infection with Coxsackievirus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Coxsackievirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12066
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12066
    ] .

obo:VO_0001229
    obo:IAO_0000115 "A protozoan vaccine that protects against infection with Schistosoma japonicum" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Schistosoma japonicum vaccine"@en ;
    rdfs:subClassOf obo:VO_0003047, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0001230
    obo:IAO_0000115 "a bacterial vaccine against Treponema pallidum infection" ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Treponema pallidum vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_160
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_160
    ] .

obo:VO_0001231
    obo:IAO_0000115 "A vaccine that protects against Leishmania major." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Leishmania major vaccine"@en ;
    rdfs:subClassOf obo:VO_0000762 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0001232
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "protective antigen" ;
    rdfs:subClassOf obo:OBI_1110034 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0001233
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a viral vaccine"@en ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "viral vaccine preparation" ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000609
    ] .

obo:VO_0001234
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a protozoan vaccine"@en ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "protozoan vaccine preparation" ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000417
    ] .

obo:VO_0001235
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a fungal vaccine"@en ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "fungal vaccine preparation" ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000267
    ] .

obo:VO_0001236
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a cancer vaccine"@en ;
    a owl:Class ;
    rdfs:label "preparation of cancer vaccine"@en ;
    rdfs:subClassOf obo:VO_0000590, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000299 ;
        owl:someValuesFrom obo:VO_0000177
    ] .

obo:VO_0001237
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant compsed of CpG DNA." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "PMID: 12899580" ;
    a owl:Class ;
    rdfs:label "CpG DNA vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001238
    obo:IAO_0000115 "Ribi vaccine adjuvant is an emulsion vaccine adjuvant that is a stable oil-in-water emulsion." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=M6661%7CSIGMA&N25=0&QS=ON&F=SPEC" ;
    a owl:Class ;
    rdfs:label "Ribi vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001239
    obo:IAO_0000115 "a synthetic vaccine adjuvant named RC529 that is a lipid A mimetic." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 16204643" ;
    a owl:Class ;
    rdfs:label "RC529 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001240
    obo:IAO_0000115 "An aluminum vaccine adjuvant that is aluminum potassium sulfate (AlK(SO4)2)." ;
    obo:IAO_0000117 "ZX, SGS" ;
    a owl:Class ;
    rdfs:label "aluminum potassium sulfate adjuvant" ;
    rdfs:subClassOf obo:VO_0000884 .

obo:VO_0001241
    obo:IAO_0000115 "An aluminum hydroxide vaccine adjuvant that is a gel that is made by precipitation of aluminum hydroxide Al(OH)3 under alkaline conditions." ;
    obo:IAO_0000117 "ZX, SGS" ;
    obo:IAO_0000118 "Alhydrogel" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Alhydrogel vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000127 .

obo:VO_0001242
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant made of the B subunit of the cholera toxin from Vibrio cholerae." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "CTB", "cholera toxin B" ;
    a owl:Class ;
    rdfs:label "cholera toxin B subunit vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001348 .

obo:VO_0001243
    obo:IAO_0000115 """a shortcut relation that equals to:
'processed material' and (is_specified_output_of some 'vaccine preparation') and ('has function' some ('vaccine function' and ('is realized by' only ('vaccine immunization' and (realizes some ('vaccine host role' and (role_of some 'organism')))))))).
The domain of this relation is a vaccine.
The range of this relation is a organism."""@en ;
    obo:IAO_0000117 "YL", "Yongqun He" ;
    obo:IAO_0000118 "immunization for host", "vaccine immunization for host" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "immunizes host" ;
    rdfs:range obo:OBI_0100026 .

obo:VO_0001244
    obo:IAO_0000117 "Allen Xiang, Oliver He, Kallan Roan" ;
    obo:IAO_0000119 "https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm201667.htm", "https://www.prevnar13.com/" ;
    obo:VO_0003099 "Prevnar 13" ;
    obo:VO_0003158 "Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein)" ;
    obo:VO_0003159 "Wyeth Pharmaceuticals, Inc" ;
    obo:VO_0003160 """- Active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F in children 6 weeks through 5 years of age (prior to the 6th birthday).
- Active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F. No otitis media efficacy data are available for serotypes 1, 3, 5, 6A, 7F, and 19A In children 6 weeks through 5 years of age (prior to the 6th birthday).
- Active immunization for the prevention of invasive disease caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F in children 6 years through 17 years of age (prior to the 18th birthday). 
- Active immunization for the prevention of pneumonia and invasive disease caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F in adults 18 years of age and older.
- Limitations: Prevnar 13 does not protect against disease caused by S. pneumoniae serotypes that are not in the vaccine.""" ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM574852.pdf" ;
    obo:VO_0003162 125324 ;
    a owl:Class ;
    rdfs:label "Prevnar 13" ;
    rdfs:seeAlso "CVX: 133", "VIOLIN Vaccine ID: 1114" ;
    rdfs:subClassOf obo:VO_0000424, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003333
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003334
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003335
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003337
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003338
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003339
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003342
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003343
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003344
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003345
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003346
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001245
    obo:IAO_0000115 "SYNFLORIX is indicated for active immunization of infants and children from 6 weeks up to 5 years of age against Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F and invasive disease caused by these serotypes (including sepsis, meningitis, bacteraemic pneumonia, pleural empyema and bacteraemia). " ;
    obo:IAO_0000117 "ZX" ;
    obo:IAO_0000119 "WEB: http://www.gsk.ca/english/docs-pdf/product-monographs/Synflorix.pdf" ;
    a owl:Class ;
    rdfs:label "Synflorix" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1115" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0001246
    obo:IAO_0000117 "Kallan Roan, Oliver He"^^xsd:anyURI ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm201342.htm"^^xsd:anyURI ;
    obo:VO_0003099 "Menveo"^^xsd:anyURI ;
    obo:VO_0003158 "Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Novartis Vaccines and Diagnostics, Inc."^^xsd:anyURI ;
    obo:VO_0003160 "For active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y and W-135 when administered to individuals 2 months to 55 years of age."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "125300"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Menveo" ;
    rdfs:seeAlso "CVX: 136", "VIOLIN Vaccine ID: 1113" ;
    rdfs:subClassOf obo:VO_0003441, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001256
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004836
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004837
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004838
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004839
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000971 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001247
    a owl:Class ;
    rdfs:label "AREPANRIX H1N1" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1116" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0001248
    a owl:Class ;
    rdfs:label "Intanza" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1117" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0001249
    obo:IAO_0000115 "an aqueous formula of the synthetic vaccine adjuvant RC529." ;
    obo:IAO_0000116 """RC529-AF can be obtained from Corixa Corporation (Seattle, WA).
Reference: PMID: 15308371""" ;
    obo:IAO_0000118 "RC529 vaccine adjuvant in an aqueour formulation" ;
    a owl:Class ;
    rdfs:label "RC529-AF vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001239 .

obo:VO_0001250
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant derived from the lipopolysaccharide (LPS) of Salmonella minnesota R595." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "3-O-deacylated monophosphoryl lipid A vaccine adjuvant", "3D-MLA", "MPL vaccine adjuvant" ;
    obo:IAO_0000119 "PMID: 7551218", "https://www.frontiersin.org/articles/10.3389/fimmu.2020.577823" ;
    a owl:Class ;
    rdfs:label "monophosphoryl lipid A vaccine adjuvant" ;
    rdfs:seeAlso "PMID: 10768940" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001251
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant that is a mutant form of LT containing a Ser-Lys substitution in position 63 which has been shown to be totally devoid of toxicity stable to protease treatment and able to act as mucosal adjuvant." ;
    obo:IAO_0000116 "LTK63 is an enzymatically inactive mutant of the heat-labile enterotoxin of Escherichia coli. It can be used as a potent mucosal adjuvant." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 9607006" ;
    a owl:Class ;
    rdfs:label "LTK63 vaccine mutant" ;
    rdfs:seeAlso "PMID: 10790422; PMID: 17920733" ;
    rdfs:subClassOf obo:VO_0000388 .

obo:VO_0001252
    obo:IAO_0000115 "is a bacterial toxin (usually an exotoxin) whose toxicity has been weakened or suppressed either by chemical (formalin) or heat treatment, while other properties, typically immunogenicity, are maintained." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Toxoid" ;
    a owl:Class ;
    rdfs:label "toxoid" ;
    rdfs:subClassOf obo:OBI_0000047 .

obo:VO_0001253
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "capsular polysaccharide subunit vaccine" ;
    rdfs:subClassOf obo:VO_0000534, obo:VO_0001255 .

obo:VO_0001254
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "capsular polysaccharide of pathogen organism as vaccine component" ;
    rdfs:subClassOf obo:VO_0001256 .

obo:VO_0001255
    obo:IAO_0000115 "a subunit vaccine that uses polysaccharide as protective antigen" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "polysaccharide subunit vaccine" ;
    rdfs:subClassOf obo:VO_0000534 .

obo:VO_0001256
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "polysaccharide of pathogen organism as vaccine component" ;
    rdfs:subClassOf obo:VO_0000000 .

obo:VO_0001257
    obo:IAO_0000117 "YH", "is the specification of an objective to prevent a disorder." ;
    a owl:Class ;
    rdfs:label "prevention of disorder objective" ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:VO_0001258
    obo:IAO_0000117 "YH", "is the specification of an objective to ameliorate  a disorder." ;
    a owl:Class ;
    rdfs:label "amelioration of disorder objective" ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:VO_0001259
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant derived from heat-killed Corynebacterium parvum." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 5483667" ;
    a owl:Class ;
    rdfs:label "killed Corynebacterium parvum vaccine adjuvant" ;
    rdfs:seeAlso "PMID: 4596278; PMID: 7591056" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001260
    obo:IAO_0000115 "Titermax Gold is an emulsion vaccine adjuvant which is a water-in-oil adjuvant with CRL-8300 (a block copolymer), squalene, and sorbitan monooleate." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Titermax Gold" ;
    a owl:Class ;
    rdfs:comment "It's a water-in-oil emulsion adjuvant. Reference: http://www.titermax.com/i_gold4.htm." ;
    rdfs:label "Titermax Gold vaccine adjuvant" ;
    rdfs:seeAlso "URL: http://www.titermax.com/i_gold4.htm" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001261
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is dimethyldioctadecylammonium bromide (DDA), a lipophilic quaternary ammonium salt known as a good adjuvant when co-administered systemically or nasally with an antigen." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Dimethyl dioctadecyl ammonium bromide" ;
    a owl:Class ;
    rdfs:label "DDA vaccine adjuvant" ;
    rdfs:seeAlso "PMID: 1439129" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001262
    obo:IAO_0000115 "A liposome-based vaccine adjuvant that have a positive surface charge." ;
    obo:IAO_0000117 "SGS" ;
    a owl:Class ;
    rdfs:label "cationic liposomal vaccine adjuvant DDA:TDB" ;
    rdfs:seeAlso "PMID: 19874860" ;
    rdfs:subClassOf obo:VO_0000366 .

obo:VO_0001263
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 7551218", "a tenosactive compound vaccine adjuvant that contains purified extract from the bark of the South American tree Quillaja saponaria Molina." ;
    a owl:Class ;
    rdfs:label "QuilA vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001358 .

obo:VO_0001264
    obo:IAO_0000115 "A combination vaccine adjuvant comprised of monophosphoryl lipid A (MPL), QS21 and an oil in water emulsion." ;
    obo:IAO_0000117 "SGS" ;
    a owl:Class ;
    rdfs:comment "monophosphoryl lipid A (MPL), QS21 and an oil in water emulsion." ;
    rdfs:label "AS02 vaccine adjuvant" ;
    rdfs:seeAlso "PMID: 15780441; PMID: 15187142" ;
    rdfs:subClassOf obo:VO_0001354 .

obo:VO_0001265
    obo:IAO_0000117 "AS04 is a combination vaccine adjuvant that is a combination of 50 μg of the immunoenhancer MPL (3-O-desacyl-4′-monophosphoryl lipid A) with 500 μg of aluminium salt.", "SGS" ;
    obo:IAO_0000119 "PMID: 21527299" ;
    a owl:Class ;
    rdfs:label "AS04 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001354 .

obo:VO_0001266
    obo:IAO_0000115 "VSA-3 is an emulsion vaccine adjuvant which is an emulsion plus DDA." ;
    obo:IAO_0000118 "Emulsigen D", "VSA-3" ;
    obo:IAO_0000119 "PMID:16187717", "SGS" ;
    a owl:Class ;
    rdfs:label "VSA-3 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001267
    obo:IAO_0000115 "a tensoactive compound vaccine adjuvant that is derived from saponin, a compound that is an immunostimulator found in the plant P. senega." ;
    a owl:Class ;
    rdfs:label "saponin vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001358 .

obo:VO_0001268
    obo:IAO_0000115 "A Montanide vaccine adjuvant that is formulated as water-in-oil emulsions and induces high antibody titers in several animal species. It is a vaccine adjuvant composed of metabolizable oil and a surfactant system designed to make a water-in-oil emulsion. It has been used since 1992 in more than 50 clinical trials related to therapeutic vaccines against various diseases such as cancer and malaria." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "Montanide ISA 720", "Montanide ISA 720 VG" ;
    obo:IAO_0000119 "WEB: http://www.seppic.com/human-health/vaccine-adjuvant/montanide-isa-720-@/view-1044-seproduit.html?menuid=,979,&lang=en" ;
    a owl:Class ;
    rdfs:label "Montanide ISA 720 vaccine adjuvant" ;
    rdfs:seeAlso "PMID: 15752840" ;
    rdfs:subClassOf obo:VO_0001271 .

obo:VO_0001269
    obo:IAO_0000115 "a montanide vaccine adjuvant that is a mineral oil adjuvant." ;
    a owl:Class ;
    rdfs:label "Montanide incomplete Seppic adjuvant" ;
    rdfs:subClassOf obo:VO_0001271 .

obo:VO_0001270
    obo:IAO_0000115 "A montanide vaccine adjuvant that is a vaccine adjuvant composed of a light mineral oil and a surfactant system designed to make a water-in-oil emulsion." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Montanide ISA51" ;
    obo:IAO_0000119 "WEB: http://www.seppic.com/human-health/vaccine-adjuvant/montanide-isa-51-@/view-1042-seproduit.html?menuid=,979,&lang=en" ;
    a owl:Class ;
    rdfs:label "Montanide ISA51 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001271 .

obo:VO_0001271
    obo:IAO_0000115 "An emulsion vaccine adjuvant developed by Montanide (http://www.montanide.com/)." ;
    obo:IAO_0000117 "YH, SS" ;
    a owl:Class ;
    rdfs:label "Montanide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001272
    obo:IAO_0000117 "YH, SS" ;
    obo:IAO_0000118 "B subunit of E. coli heat-labile enterotoxin" ;
    obo:IAO_0000119 "A microbial derivative vaccine adjuvant composed of the B subunit of E. coli heat-labile toxin." ;
    a owl:Class ;
    rdfs:label "EtxB vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000388 .

obo:VO_0001273
    obo:IAO_0000115 "A synthetic vaccine adjuvant with the tradename Polygen." ;
    obo:IAO_0000117 "YH, SS" ;
    a owl:Class ;
    rdfs:label "Polygen vaccine adjuvant" ;
    rdfs:seeAlso "URL: http://www.mvp-technologies.com/adjuvants/Polygen%20Final%20Technical%20Bulletin.pdf" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001274
    obo:IAO_0000115 "a role of host that contains vaccine. It is a role that inheres in an organism that is the target of a vaccine administration (vaccination process)." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "vaccine host role" ;
    rdfs:subClassOf obo:OBI_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000054 ;
        owl:someValuesFrom obo:VO_0000490
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000052 ;
        owl:someValuesFrom obo:OBI_0100026
    ] .

obo:VO_0001275
    obo:IAO_0000117 "YH, ZX", "a role that represents a target (i.e., some disorder) of immunization." ;
    a owl:Class ;
    rdfs:label "immunization target role" ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0001276
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "bacterial vaccine immunization" ;
    rdfs:subClassOf obo:VO_0000494 .

obo:VO_0001277
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "viral vaccine immunization" ;
    rdfs:subClassOf obo:VO_0000494 .

obo:VO_0001278
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer vaccine immunization" ;
    rdfs:subClassOf obo:VO_0000494 .

obo:VO_0001279
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "parasite vaccine immunization" ;
    rdfs:subClassOf obo:VO_0000494 .

obo:VO_0001280
    a owl:Class ;
    rdfs:label "immunization target role of pathogen" ;
    rdfs:subClassOf obo:VO_0001275 .

obo:VO_0001281
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "immunization target role of bacterial pathogen" ;
    rdfs:subClassOf obo:VO_0001280 .

obo:VO_0001282
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "immunization target role of viral pathogen" ;
    rdfs:subClassOf obo:VO_0001280 .

obo:VO_0001283
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "immunization target role of parasite pathogen" ;
    rdfs:subClassOf obo:VO_0001280 .

obo:VO_0001284
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "immunization target role of fungal pathogen" ;
    rdfs:subClassOf obo:VO_0001280 .

obo:VO_0001285
    obo:IAO_0000117 "A nonantigenic carbohydrate adjuvant, which enhances both humoral and cell-mediated immunity to oligopeptides in experimental animal models.", "SGS" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Algal Glucan vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001359 .

obo:VO_0001286
    obo:IAO_0000115 "A suspension of 1-2μm ovoids of immune stimulant gamma inulin (g-IN) in which alum is embedded as a carrier for protein or other anionic antigens." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID:1887671" ;
    a owl:Class ;
    rdfs:label "Algammulin vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001354 .

obo:VO_0001287
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is Bay R1005 (N-(2-Deoxy-2-L-leucylamino β-D-glucopyranosyl)-N-octadecyldodecanoylamide hydroacetate )." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "BAY R1005", "N-( 2-Deoxy-2-L-leucylamino-β-D-glucopyranosyl)-N-octadecyldodecanoylamide hydroacetate" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "BAY R1005 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001288
    obo:IAO_0000115 "A synthetic vaccine adjuvant that is N, N-dioctadecyl-N′, N′-bis( 2-hydroxyethyl) propanediamine (Avridine)." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Avridine", "CP20,96", "N, N-dioctadecyl-N′, N′-bis( 2-hydroxyethyl) propanediamine" ;
    obo:IAO_0000119 "PMID:7551218" ;
    a owl:Class ;
    rdfs:label "Avridine vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001289
    obo:IAO_0000115 "a calcium phosphate vaccine adjuvant that is a gel prepared by precipitating soluable calcium and phosphate salts." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "calcium phosphate gel" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "calcium phosphate gel vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000131 .

obo:VO_0001290
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant composed of the CTA1-DD fusion protein." ;
    obo:IAO_0000118 "CTA1-DD gene fusion protein" ;
    obo:IAO_0000119 "PMID: 7551218", "SGS" ;
    a owl:Class ;
    rdfs:label "Cholera toxin A1-subunit-ProteinA D-fragment fusion protein" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001291
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "DOC/Alum Complex" ;
    obo:IAO_0000119 "A mineral salt vaccine adjuvant that is composed of Deoxycholic acid sodium salt (DOC) complexed with aluminum hydroxide.", "PMID:7551218" ;
    a owl:Class ;
    rdfs:label "DOC/Alum Complex vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000093 .

obo:VO_0001292
    obo:IAO_0000115 "gamma inulin is a carbohydrate adjuvant that is a highly specific activator of the alternative pathway of complement in vitro and in vivo, and is composed of linear (unbranched) b-D-(2-1) polyfructofuranosyl-a-D-glucose." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 3265692; PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "gamma Inulin vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001359 .

obo:VO_0001293
    obo:IAO_0000115 "Gerbu adjuvant is a combination vaccine adjuvant that is comprised of a mixture of GMDP, DDA, and Zinc L-proline salt complex (ZnPro8)." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 """PMID: 7551218
PMID: 15953835""" ;
    a owl:Class ;
    rdfs:label "Gerbu vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001354 .

obo:VO_0001294
    obo:IAO_0000115 "a cytokine vaccine adjuvant that includes GM-CSF." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "GM-CSF vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001295
    obo:IAO_0000115 "A synthetic vaccine adjuvant containing GMDP, a higly effective primary adjuvant." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "GMDP", "N-acetylglucosaminyl-(b1-4)-N-acetylmuramyl-L-alanyl-D-isoglutamine" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "GMDP vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001296
    obo:IAO_0000115 "an IFN-gamma vaccine adjuvant that is composed of recombinant hIFN-gamma." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "recombinant hIFN-gamma/Interferon-g vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001360 .

obo:VO_0001297
    obo:IAO_0000115 "a cytokine vaccine adjuvant that includes IL-1b." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "interleukin-1b vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001298
    obo:IAO_0000115 "a cytokine vaccine adjuvant that includes IL-2." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "IL-2 vaccine adjuvant" ;
    a owl:Class ;
    rdfs:label "interleukin-2 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001299
    obo:IAO_0000115 "a cytokine vaccine adjuvant that includes IL-7." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "IL-7 vaccine adjuvant" ;
    a owl:Class ;
    rdfs:label "interleukin-7 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001300
    obo:IAO_0000115 "a synthetic vaccine adjuvant loxoribine is a guanosine analog derivatized at position N7 and C8, and activates TLR-7." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "7-allyl-8-oxoguanosine", "Loxoribine" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Loxoribine vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001301
    obo:IAO_0000115 "An emulsion vaccine adjuvant consisting of an oil (squalene)-in-water nano emulsion.", "PMID: 20488726" ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "MF59" ;
    a owl:Class ;
    rdfs:label "MF59 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001302
    obo:IAO_0000115 "MTP-PE liposomes are a liposome-based vaccine adjuvant that consists of liposomes containing  the synthetic lipophilic analog of muramyl dipeptide, muramyl tripeptide phosphatidylethanolamine (MTP-PE)." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "MTP-PE", "MTP-PE Liposomes" ;
    obo:IAO_0000119 "PMID: 1431559" ;
    a owl:Class ;
    rdfs:label "MTP-PE Liposomes vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000366 .

obo:VO_0001303
    obo:IAO_0000115 "a synthetic vaccine adjuvant made of murametide that has adjuvant activity similar to MDP." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Murametide", "Nac-Mur-L-Ala-D-Gln-OCH3" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Murametide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001304
    obo:IAO_0000115 "a synthetic vaccine adjuvant called murapalmitine." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Murapalmitine", "Nac-Mur-L-Thr-D-isoGIn-sn-glyceroI dipalmitoyl" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Murapalmitine vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001305
    obo:IAO_0000115 "a synthetic adjuvant that is an MDP analog called D-Murapalmitine." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "D-Murapalmitine", "Nac-Mur-D-Ala-D-isoGln-sn-glycerol dipalmitoyl" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "D-Murapalmitine vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001306
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is composed of neuraminidase-galactose oxidase (NAGO) a mixture of mixture of the two enzymes-neuraminidase and galactose oxidase." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "NAGO", "Neuraminidase-galactose oxidase" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "NAGO vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001307
    obo:IAO_0000115 "a synthetic vaccine adjuvant consisting of multi-lamellar vesicles comprising a mixture of non-ionic surfactant (e.g., 1-monopalmitoyl-rac-glycerol), cholesterol and dicetyl phosphate used as a primary vaccine adjuvant for entrapped antigen." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "NISV", "non-ionic surfactant vesicles" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "non-ionic surfactant vesicles vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001308
    obo:IAO_0000115 "a synthetic vaccine adjuvant made from the emulsion polymerization of methyl methacrylate." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "PMMA", "Polymethyl methacrylate" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "PMMA vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001309
    obo:IAO_0000115 "a synthetic vaccine adjuvant synthesized from stable protein phospholipid-calcium precipitates." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "protein cochleates" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "protein cochleates vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001310
    obo:IAO_0000115 "A tensoactive compound vaccine adjuvant that is composed of extracts from the bark of the Quillaja saponaria Molina tree. Specifically, it is an acylated 3, 28-bisdesmodic triterpene glycosides (1,3) or “saponin” with a molecular formula of C92O46H148 and molecular weight of 1990 Da. QS-21 is one of the active fractions of the bark of Chilean tree, Quillaja saponaria, purified using a reverse-phase chromatography (RP-HPLC)." ;
    obo:IAO_0000117 "SGS, Randi Vita, Oliver He" ;
    obo:IAO_0000118 "QS-21", "Stimulon™ QS-21 Adjuvant" ;
    obo:IAO_0000119 "PMID: 7551218", "QS21 vaccine adjuvant", "https://pubmed.ncbi.nlm.nih.gov/27213168/" ;
    a owl:Class ;
    rdfs:label "QS-21 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001267 .

obo:VO_0001311
    obo:IAO_0000115 "An aluminum vaccine adjuvant that is a synthetic oxyhydroxide of aluminum (aluminum hydroxide) prepared by acid-base precipitation." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Rehydragel HPA" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Rehydragel HPA vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000884 .

obo:VO_0001312
    obo:IAO_0000115 "An aluminum hydroxide vaccine adjuvant that is a low visosity aluminum hydroxide gel." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Rehydragel LV" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Rehydragel LV vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000127 .

obo:VO_0001313
    obo:IAO_0000115 "a cytokine vaccine adjuvant that contains the 163-171 peptide of IL-1β." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "IL-1β 163-171 peptide vaccine adjuvant", "Sclavo peptide" ;
    a owl:Class ;
    rdfs:label "Sclavo peptide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001314
    obo:IAO_0000115 "Specon is an emulsion vaccine adjuvant that is a water-in-oil emulsion that is used as an adjuvant and has immunostimulating properties similar to Freund's complete adjuvant (FCA)." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Specol" ;
    obo:IAO_0000119 "PMID: 1439130" ;
    a owl:Class ;
    rdfs:label "Specol vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001315
    obo:IAO_0000115 "SPT is an emulsion vaccine adjuvant that is an emulsion of squalane (5%), Tween 80( 0.2%), Pluronic L121( 1.25%), phosphate-buffered saline pH 7.4, and antigen." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "SPT (Antigen Formulation)" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001316
    obo:IAO_0000115 "a synthetic vaccine adjuvant stearyl tyrosine is considered an \"organic equivelant\" of aluminum hydroxide." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "stearyl tyrosine" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "stearyl tyrosine vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001317
    obo:IAO_0000115 "a synthetic vaccine adjuvant called Theramide that is composed of N-acetylglucosaminyl-N-acetylinuramyl-L-Ala-D-isoGlu-L-Ala-dipalmitoxy propylamide (DTP-DPP)." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Theramide" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Theramide vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001318
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is a copolymer (CRL1005), based on a 12 kDa polyoxypropylene (POP) core with 5% POE." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "CRL1005" ;
    obo:IAO_0000119 "PMID: 10717336" ;
    a owl:Class ;
    rdfs:label "CRL1005 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001319
    obo:IAO_0000115 "Nanoemulsion vaccine adjuvant is an emulsion vaccine adjuvant and is made from non-toxic lipid droplets a few hundred nanometers in diameter and made from surfactants approved for human consumption and common food substances that are 'Generally Recognized as Safe' (GRAS) by the FDA." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "http://nano.med.umich.edu/platforms/Nanoemulsions.html" ;
    a owl:Class ;
    rdfs:label "nanoemulsion vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001320
    obo:IAO_0000115 "AS03 is an emusion vaccine adjuvant that contains α-tocopherol and squalene, two biodegradable polyprenyls, in an oil-in-water emulsion." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "AS03" ;
    obo:IAO_0000119 "PMID: 21256188" ;
    a owl:Class ;
    rdfs:label "AS03 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001321
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "LTR192G" ;
    obo:IAO_0000119 "A microbial deriviative vaccine adjuvant that is a mutant form of E.coli heat-labile toxin.", "PMID: 11803061" ;
    a owl:Class ;
    rdfs:label "LTR192G vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000388 .

obo:VO_0001322
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant containing E. coli heat-labile toxin." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "E. coli heat-labile toxin, LT", "LT Oral Adjuvant", "LT-OA" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "E. coli heat-labile toxin vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001323
    obo:IAO_0000115 "An aluminum vaccine adjuvant that is a a proprietary aluminum hydroxyphosphate sulfate formulation that is both physically and functionally distinct from traditional aluminum phosphate and aluminum hydroxide adjuvants." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "AAHSA", "Merck Aluminum Adjuvant" ;
    obo:IAO_0000119 "PMID: 17581283" ;
    a owl:Class ;
    rdfs:label "amorphous aluminum hydroxyphosphate sulfate adjuvant" ;
    rdfs:subClassOf obo:VO_0000884 .

obo:VO_0001324
    obo:IAO_0000118 "Matrix-S" ;
    a owl:Class ;
    rdfs:label "Matrix-S vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001358 .

obo:VO_0001325
    obo:IAO_0000118 "Brucella BFR antigen vaccine", "recombinant Brucella abortus Bfr protein vaccine" ;
    a owl:Class ;
    rdfs:label "Brucella abortus subunit vaccine using Bfr" ;
    rdfs:seeAlso "PMID: 11447155" ;
    rdfs:subClassOf obo:VO_0001221 .

obo:VO_0001326
    obo:IAO_0000118 "Brucella abortus Omp16 vaccine" ;
    a owl:Class ;
    rdfs:label "Brucella abortus subunit vaccine using Omp16" ;
    rdfs:seeAlso "PMID: 18981242" ;
    rdfs:subClassOf obo:VO_0001221 .

obo:VO_0001327
    a owl:Class ;
    rdfs:label "B. melitensis DNA vaccine encoding Bp26 and Tf" ;
    rdfs:subClassOf obo:VO_0001226 .

obo:VO_0001328
    obo:IAO_0000115 "a synthetic vaccine adjuvant contiaing imiquimod a imidazoquinoline." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "1-(2-methypropyl)-IH-imidazo[4,5-c]quinolin-4-amine", "Aldara™", "R-837", "S26308" ;
    obo:IAO_0000119 "PMID: 7551218, PMID: 18566444" ;
    a owl:Class ;
    rdfs:label "imiquimod vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001329
    obo:IAO_0000115 "a synthetic vaccine adjuvant, resiquimod is a chemical analog of imiquimod." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 15068862" ;
    a owl:Class ;
    rdfs:label "resiquimod vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001330
    obo:IAO_0000115 "An emulsion vaccine adjuvant containing 2.5% squalene." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID:20193791" ;
    a owl:Class ;
    rdfs:label "AF03 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0001331
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant composed of flagellin from gram-negative bacteria." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "FliC" ;
    obo:IAO_0000119 "PMID: 16428759, PMID: 21048152" ;
    a owl:Class ;
    rdfs:label "Flagellin vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001332
    obo:IAO_0000115 "a synthetic vaccine adjuvant containing Poly(I:C), a synthetic double stranded analog of RNA." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "polyriboinosinic-polyribocytidylic acid" ;
    obo:IAO_0000119 "WEB: http://en.wikipedia.org/wiki/Polyinosinic:polycytidylic_acid" ;
    a owl:Class ;
    rdfs:label "poly(I:C) vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001333
    obo:IAO_0000115 "a particulate antigen delivery system that is a vaccine adjuvant comprising cholesterol, phospholipid and saponin but without antigen." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 19450632" ;
    a owl:Class ;
    rdfs:comment "ISCOMATRIX is identical to ISCOMs except that it does not contain antigen. Ref: PMID: 17336431." ;
    rdfs:label "ISCOMATRIX vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001356 .

obo:VO_0001334
    obo:IAO_0000115 "a tensoactive compound vaccine adjuvant that is made from highly purified saponins." ;
    obo:IAO_0000117 "SGS, YH" ;
    obo:IAO_0000119 "WEB: http://www.isconova.com/products/abisco-research-reagent/abisco-100.aspx" ;
    a owl:Class ;
    rdfs:label "Abisco-100 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001267 .

obo:VO_0001335
    obo:IAO_0000115 "a particulate antigen delivery system  that is albumin-heparin microparticles vaccine adjuvant that is prepared from albumin and heparin stabilized by cross-linking reaction with EDC." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 16734558" ;
    a owl:Class ;
    rdfs:label "albumin-heparin microparticles vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001356 .

obo:VO_0001336
    obo:IAO_0000115 "SmithKline Beecham adjuvant system 2  (AS-2) is a combination vaccine adjuvant and is based on the combination of Monophosphoryl Lipid A(MPL), QS21 (a purified fraction of Saponin extracted from Quillarja Saponaria), and a proprietary oil in water emulsion." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "http://www.pasteur.fr/applications/euroconf/vaccins/vaccins-abs.html" ;
    a owl:Class ;
    rdfs:label "AS-2 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001354 .

obo:VO_0001337
    obo:IAO_0000115 "a cytokine vaccine adjuvant that includes B7-2." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "B7-2 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001338
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is a local anaesthetic drug belonging to the amino amide group, and is used as a vaccine adjuvant in DNA vaccines." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 15246629, WEB: http://en.wikipedia.org/wiki/Bupivacaine" ;
    a owl:Class ;
    rdfs:label "Bupivacaine vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001339
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "cationic liposome-DNA complex JVRS-100" ;
    obo:IAO_0000119 "A liposome-based vaccine adjuvant that is composed of virus sized liposomes that contain a DNA plasmid.", "PMID: 19285425" ;
    a owl:Class ;
    rdfs:label "cationic liposome-DNA complex JVRS-100 vaccin adjuvant" ;
    rdfs:subClassOf obo:VO_0000366 .

obo:VO_0001340
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "5-androsten-3β-ol-17-one", "DHA", "Dehydroepiandrosterone", "androstenolone", "prasterone", "transdehydroandrosterone" ;
    obo:IAO_0000119 "PMID: 7551218", "a synthetic vaccine adjuvant that is DHEA, which is relatively stable and can be directly incorporated into vaccine formulations." ;
    a owl:Class ;
    rdfs:label "DHEA vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001341
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is PLGA, which has been used in the controlled delivery of peptide drugs." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "PLGA", "PLGA microspheres", "Polyester poly (DL-lactide-co-glycolide)" ;
    obo:IAO_0000119 "PMID: 15560948" ;
    a owl:Class ;
    rdfs:label "DL-PGL (Polyester poly (DL-lactide-co-glycolide)) vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001342
    obo:IAO_0000115 "a cytokine vaccine adjuvant that uses the adjuvant effect of cytokine IL-15." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "IL-15 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001343
    obo:IAO_0000115 "immunoliposomes containing antibodies to costimulatory molecules is a liposome-based vaccine adjuvant which is prepared from dehydration-rehydration vesicles (DRVs)." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "immunoliposomes containing antibodies to costimulatory molecules" ;
    rdfs:subClassOf obo:VO_0000366 .

obo:VO_0001344
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant that is a mutant form of heat-labile Escherichia coli enterotoxin (LT) that contains a substitution Ala → Arg in position 72 of the A subunit." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 9529328" ;
    a owl:Class ;
    rdfs:label "LTK72 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000388 .

obo:VO_0001345
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant containing MPL and squalene." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 12213399" ;
    a owl:Class ;
    rdfs:label "MPL-SE vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001346
    obo:IAO_0000115 "a vaccine preservative that contains formaldehyde." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000119 "WEB: http://www.mja.com.au/public/issues/184_04_200206/eld10500_fm.pdf" ;
    a owl:Class ;
    rdfs:label "formaldehyde vaccine preservative" ;
    rdfs:subClassOf obo:VO_0000851, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000885
    ] .

obo:VO_0001347
    obo:IAO_0000115 "A microbial derived vaccine adjuvant made of E112K mC,  a mutated CT created by substituting a single amino acid in the ADP-ribosyltransferase active centre, glutamate to lysine at position 112." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "mCT", "non-toxic mutant E112K of Cholera Toxin mCT-E112K" ;
    obo:IAO_0000119 "PMID: 11251876:" ;
    a owl:Class ;
    rdfs:label "non-toxic mutant E112K of Cholera Toxin mCT-E112K vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001348 .

obo:VO_0001348
    obo:IAO_0000115 "a microbial derivative vaccine adjuvant that is derived from cholera toxin." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "cholera toxin derived vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001349
    obo:IAO_0000115 "SAF-1 is a combination vaccine adjuvant that is composed of threonyl-MDP (0.05-1%) in an emulsion vehicle [5% squalane, 2.5% Pluronic® L121, 0.2% Polysorbate 80 and phosphate buffered saline (pH 7.4)]." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "SAF-1 vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001354 .

obo:VO_0001350
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000119 "A liposome-based vaccine adjuvant that includes the glycoproteins of Sendai virus.", "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "Sendai Proteoliposomes, Sendai-containing Lipid Matrices" ;
    rdfs:subClassOf obo:VO_0000366 .

obo:VO_0001351
    obo:IAO_0000115 "a synthetic vaccine adjuvant that is threonyl muramyl dipeptide (TMDP)." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "N-acetyl muramyl-L-threonyl-D-isoglutamine", "Termurtide™", "[thr1 ]-MDP" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "threonyl muramyl dipeptide (TMDP) vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001357 .

obo:VO_0001352
    obo:IAO_0000115 "A microbial derivative vaccine adjuvant made of virus like particles (VLPS) containing the yeast retrotransposon Ty which has the amino acids 1-381 of the pI protein encoded." ;
    obo:IAO_0000117 "SGS" ;
    obo:IAO_0000118 "Ty-VLPs" ;
    obo:IAO_0000119 "PMID: 7551218" ;
    a owl:Class ;
    rdfs:label "ty particles vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0001353
    obo:IAO_0000117 "YH, SGS", "a vaccine adjuvant that contains active cytokine compound." ;
    a owl:Class ;
    rdfs:label "cytokine vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0001354
    obo:IAO_0000117 "YH, SGS", "a vaccine adjuvant that is composed of differnt compounds under more than one category." ;
    a owl:Class ;
    rdfs:label "combination vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0001355
    a owl:Class ;
    rdfs:label "emulsion vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0001356
    obo:IAO_0000115 "a vaccine adjuvant that serves as a particulate antigen delivery system." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "particulate antigen delivery system" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0001357
    obo:IAO_0000115 "A vaccine adjuvant that contains synthetic material." ;
    obo:IAO_0000117 "YH, SGS, Philip Huang" ;
    a owl:Class ;
    rdfs:label "synthetic vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0001358
    obo:IAO_0000115 "a vaccine adjuvant that includes tensioactive material. Tensioactive materials, surfactants or active surface agents are chemical substances with a polar-non polar structure. These substances have a tendency to locate themselves at the surface creating an adsorbed monomolecular layer on the interface." ;
    obo:IAO_0000117 "YH, SGS" ;
    obo:IAO_0000118 "tensioactive compound vaccine adjuvant" ;
    obo:IAO_0000119 "WEB: http://www.citt.ufl.edu/team/sepulveda/html/en_tensioactivos.htm" ;
    a owl:Class ;
    rdfs:label "tensoactive compound vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0001359
    obo:IAO_0000117 "YH, SGS", "a vaccine adjuvant that is primarily composed of carbohydrates." ;
    a owl:Class ;
    rdfs:label "carbohydrate vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0000580 .

obo:VO_0001360
    obo:IAO_0000115 "a cytokine vaccine adjuvant that includes IFN-gamma." ;
    obo:IAO_0000117 "YH, SGS" ;
    a owl:Class ;
    rdfs:label "IFN-gamma vaccine adjuvant" ;
    rdfs:subClassOf obo:VO_0001353 .

obo:VO_0001361
    obo:IAO_0000115 "a role that is inherenced in a gene that can be mutated in a virulent pathogen, leading to an attenuated strain serving as a live attenuated vaccine strain." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "virmugen role" ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0001362
    obo:IAO_0000115 "a vaccine that targets for allergy."@en ;
    obo:IAO_0000117 "YL,YH"@en ;
    dc:creator "YL, YH" ;
    a owl:Class ;
    rdfs:label "allergy vaccine" ;
    rdfs:subClassOf obo:VO_0002813 .

obo:VO_0001363
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Clostridium perfringens infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Clostridium perfringens vaccine" ;
    rdfs:subClassOf obo:VO_0000639, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1502
    ] .

obo:VO_0001364
    a owl:Class ;
    rdfs:label "human immunization objective" ;
    rdfs:subClassOf obo:VO_0000585 .

obo:VO_0001365
    obo:IAO_0000115 "A viral vaccine that protects against infection with CCHF virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    obo:IAO_0000118 "CCHF vaccine" ;
    a owl:Class ;
    rdfs:label "Crimean-Congo Haemorrhagic Fever vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11593
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11593
    ] .

obo:VO_0001366
    obo:IAO_0000115 "A viral vaccine that protects against infection with Caprine herpesvirus type 1 virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Caprine herpesvirus type 1 vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_39944
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_39944
    ] .

obo:VO_0001367
    obo:IAO_0000115 "an inactivation vaccine that is prepared by heat inactivation." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "heat-killed vaccine" ;
    rdfs:subClassOf obo:VO_0000017 .

obo:VO_0001368
    obo:IAO_0000115 "an inactivation vaccine that is prepared by irradiation inactivation." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "irradiation-inactivated vaccine" ;
    rdfs:subClassOf obo:VO_0000315 .

obo:VO_0001369
    obo:IAO_0000115 "an inactivation vaccine that is prepared by H2O2 inactivation." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "H2O2-killed vaccine" ;
    rdfs:subClassOf obo:VO_0000017 .

obo:VO_0001370
    obo:IAO_0000115 "an inactivation vaccine that is prepared by formalin inactivation." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "formalin-killed vaccine" ;
    rdfs:subClassOf obo:VO_0000017 .

obo:VO_0001371
    obo:IAO_0000115 "A vaccine prepraration process that is performed by H2O2 inactivation of virulent pathogen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "preparation of vaccine using H2O2 inactivation" ;
    rdfs:subClassOf obo:VO_0000178 .

obo:VO_0001372
    obo:IAO_0000115 "an organismal quality that indicates an organism (e.g., human) is not yet immunized against a disease." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "unimmunized" ;
    rdfs:subClassOf obo:PATO_0001995 .

obo:VO_0001373
    obo:IAO_0000115 "an organismal quality that indicates an organism (e.g., human) is immunized against a disease through vaccination with a licensed vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "immunized by vaccination with a licensed vaccine" ;
    rdfs:subClassOf obo:VO_0000151 .

obo:VO_0001374
    obo:IAO_0000115 "an organism that is vaccinated with a vaccine" ;
    obo:IAO_0000118 "vaccinated organism" ;
    a owl:Class ;
    rdfs:comment "YH, YL, MC" ;
    rdfs:label "vaccinee" ;
    rdfs:subClassOf obo:OBI_0100026 .

obo:VO_0001375
    obo:IAO_0000115 "A Streptococcus  vaccine against Streptococcus agalactiae infection." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Streptococcus agalactiae vaccine"@en ;
    rdfs:subClassOf obo:VO_0000772, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1311
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1311
    ] .

obo:VO_0001376
    obo:IAO_0000115 "an organismal quality that indicates an organism (e.g., human) is vaccinated with a vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccinated" ;
    rdfs:subClassOf obo:PATO_0001995 .

obo:VO_0001377
    obo:IAO_0000115 "an organismal quality that indicates an organism (e.g., human) is unvaccinated with any vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "unvaccinated" ;
    rdfs:subClassOf obo:PATO_0001995 .

obo:VO_0001378
    obo:IAO_0000115 "a vaccinated quality that indicates an organism is vaccinated with a licensed vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccinated with a licensed vaccine" ;
    rdfs:subClassOf obo:VO_0001376 .

obo:VO_0001379
    obo:IAO_0000115 "a unvaccinated quality that indicates an organism has not been vaccinated with a licensed vaccine." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "unvaccinated with a licensed vaccine" ;
    rdfs:subClassOf obo:VO_0001377 .

obo:VO_0001380
    obo:IAO_0000115 "a cancer vaccine that protects mice against tumor growth following challenge with live B16 cells." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "B16 vaccine adjuvanted by loxoribine" ;
    rdfs:seeAlso "PMID: 8306370" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0001381
    obo:IAO_0000115 "an organism that is immunized for a disease" ;
    a owl:Class ;
    rdfs:comment "YH, YL, MC" ;
    rdfs:label "immunized organism" ;
    rdfs:subClassOf obo:OBI_0100026 .

obo:VO_0001382
    obo:IAO_0000115 "A viral vaccine that protects against infection with Rabbit hemorrhagic disease virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "rabbit hemorrhagic disease virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11976
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11976
    ] .

obo:VO_0001383
    obo:IAO_0000115 "an organism that is unvaccinated with a vaccine" ;
    a owl:Class ;
    rdfs:comment "YH, YL, MC" ;
    rdfs:label "unvaccinated organism" ;
    rdfs:subClassOf obo:OBI_0100026 .

obo:VO_0001384
    obo:IAO_0000115 "a bacterial gene from Actinobacillus pleuropneumoniae." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Actinobacillus pleuropneumoniae gene" ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_715
    ] .

obo:VO_0001385
    obo:IAO_0000115 "A vaccine that protects against Trypanosoma cruzi." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "T. cruzi vaccine" ;
    a owl:Class ;
    rdfs:label "Trypanosoma cruzi vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5693
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5693
    ] .

obo:VO_0001386
    obo:IAO_0000115 "A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi CRP-10 protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine encoding CRP-10" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 803" ;
    rdfs:subClassOf obo:VO_0001385 .

obo:VO_0001387
    obo:IAO_0000115 "A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi G2 protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine encoding G2" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 807" ;
    rdfs:subClassOf obo:VO_0001385 .

obo:VO_0001388
    obo:IAO_0000115 "A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi G4 protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine encoding G4" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 809" ;
    rdfs:subClassOf obo:VO_0001385 .

obo:VO_0001389
    obo:IAO_0000115 "A T. cruzi DNA vaccine that uses a DNA plasmid expressing T. cruzi TSA-1 protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine encoding TSA-1" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 812" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011296
    ] .

obo:VO_0001390
    obo:IAO_0000115 "A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi TSA-1 protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine pGFP-TSA1" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 811" ;
    rdfs:subClassOf obo:VO_0001385 .

obo:VO_0001391
    obo:IAO_0000115 "A T. cruzi subunit vaccine that uses T. cruzi PAR1 protein as protective antigen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi PAR1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 806" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:VO_0011301
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:VO_0000457
                ]
            )
        ]
    ] .

obo:VO_0001392
    obo:IAO_0000115 "A T. cruzi subunit vaccine that uses T. cruzi PAR2 protein as protective antigen." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi PAR2 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 810" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000894 ;
        owl:someValuesFrom obo:VO_0011301
    ] .

obo:VO_0001393
    obo:IAO_0000115 "A T. cruzi vaccine that uses attenuated Salmonella to express T. cruzi Cruzipain protein." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi vaccine using attenuated Salmonella expressing T. cruzi Cruzipain" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 804" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000894 ;
        owl:someValuesFrom obo:VO_0011293
    ] .

obo:VO_0001394
    obo:IAO_0000115 "A T. cruzi vaccine that uses Sendai virus vector to express T. cruzi amastigote surface protein-2." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi vaccine using Sendai virus vector expressing amastigote surface protein-2" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 802" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000894 ;
        owl:someValuesFrom obo:VO_0011289
    ] .

obo:VO_0001395
    obo:IAO_0000115 "a vaccine that contains two or more individual vaccines. " ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "cocktail vaccine"@en ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0001396
    obo:IAO_0000115 "a cocktail vaccine that contains both subunit vaccine and inactivated whole organism vaccines." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "cocktail vaccine containing subunit vaccine and inactivated whole organism vaccine"@en ;
    rdfs:subClassOf obo:VO_0001395 .

obo:VO_0001397
    obo:IAO_0000115 "a prime-boost vaccine with DNA vaccine priming that contains a subunit vaccine for boosting" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine containing DNA vaccine for priming and subunit vaccine for boosting"@en ;
    rdfs:subClassOf obo:VO_0000401 .

obo:VO_0001398
    obo:IAO_0000115 "a prime-boost vaccine with a DNA vaccine priming that contains a Ad vector vaccine for boosting" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine containing DNA vaccine for priming and Ad vector vaccine for boosting"@en ;
    rdfs:subClassOf obo:VO_0000401 .

obo:VO_0001399
    obo:IAO_0000115 "a conjugate vaccine that conjugate more than one open reading frames of protective antigens or conjugate a protective antigen to a carrier protein." ;
    obo:IAO_0000116 "An example of fusion protein vaccine is Mtb72f fusion protein vaccine. Reference: PubMed: 15187142." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "fusion protein vaccine" ;
    a owl:Class ;
    rdfs:label "fusion conjugate protein vaccine"@en ;
    rdfs:subClassOf obo:VO_0000195 .

obo:VO_0001400
    obo:IAO_0000115 "A Brucella gene that is from B. melitensis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis gene"@en ;
    rdfs:subClassOf obo:VO_0000790, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_29459
    ] .

obo:VO_0001401
    obo:IAO_0000115 "A Brucella gene that is from B. suis." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella suis gene"@en ;
    rdfs:subClassOf obo:VO_0000790, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_29461
    ] .

obo:VO_0001402
    obo:IAO_0000115 "A bacterial gene that is from Bacillus anthracis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Bacillus anthracis gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0001403
    obo:IAO_0000115 "A bacterial gene that is from Listeria monocytogenes." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Listeria monocytogenes gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_1639
    ] .

obo:VO_0001404
    obo:IAO_0000115 "A bacterial gene that is from Mycobacterium avium." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Mycobacterium avium gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_1764
    ] .

obo:VO_0001405
    obo:IAO_0000115 "A bacterial gene that is from Staphylococcus aureus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Staphylococcus aureus gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0001406
    obo:IAO_0000115 "A bacterial gene that is from Aeromonas hydrophila." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Aeromonas hydrophila gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_644
    ] .

obo:VO_0001407
    obo:IAO_0000115 "A bacterial gene that is from Bordetella bronchiseptica." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Bordetella bronchiseptica gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_518
    ] .

obo:VO_0001408
    obo:IAO_0000115 "A bacterial gene that is from Aeromonas salmonicida." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Aeromonas salmonicida gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_645
    ] .

obo:VO_0001409
    obo:IAO_0000115 "A bacterial gene that is from Bordetella pertussis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0001410
    obo:IAO_0000115 "A bacterial gene that is from Borrelia burgdorferi." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Borrelia burgdorferi gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0001411
    obo:IAO_0000115 "A bacterial gene that is from Burkholderia pseudomallei." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Burkholderia pseudomallei gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_28450
    ] .

obo:VO_0001412
    obo:IAO_0000115 "A bacterial gene that is from Burkholderia pseudomallei." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Edwardsiella ictaluri gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_28450
    ] .

obo:VO_0001413
    obo:IAO_0000115 "A bacterial gene that is from Edwardsiella tarda." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Edwardsiella tarda gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_636
    ] .

obo:VO_0001414
    obo:IAO_0000115 "A bacterial gene that is from Francisella tularensis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Francisella tularensis gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_263
    ] .

obo:VO_0001415
    obo:IAO_0000115 "A bacterial gene that is from Mannheimia haemolytica." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Mannheimia haemolytica gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0001416
    obo:IAO_0000115 "A bacterial gene that is from Mycoplasma gallisepticum." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Mycoplasma gallisepticum gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_2096
    ] .

obo:VO_0001417
    obo:IAO_0000115 "A bacterial gene that is from Neisseria meningitidis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0001418
    obo:IAO_0000115 "A bacterial gene that is from Pasteurella multocida." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Pasteurella multocida gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0001419
    obo:IAO_0000115 "A bacterial gene that is from Salmonella Typhi." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Salmonella Typhi gene"@en ;
    rdfs:subClassOf obo:VO_0000168, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_90370
    ] .

obo:VO_0001420
    obo:IAO_0000115 "A bacterial gene that is from Salmonella Gallinarum." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Salmonella Gallinarum gene"@en ;
    rdfs:subClassOf obo:VO_0000168, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_594
    ] .

obo:VO_0001421
    obo:IAO_0000115 "A bacterial gene that is from Salmonella Typhimurium." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "'Salmonella Typhimurium gene"@en ;
    rdfs:subClassOf obo:VO_0000168, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_90371
    ] .

obo:VO_0001422
    obo:IAO_0000115 "A bacterial gene that is from Salmonella Enteritidis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Salmonella Enteritidis gene"@en ;
    rdfs:subClassOf obo:VO_0000168, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_149539
    ] .

obo:VO_0001423
    obo:IAO_0000115 "A bacterial gene that is from Vibrio cholerae." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Vibrio cholerae gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_666
    ] .

obo:VO_0001424
    obo:IAO_0000115 "A viral gene that is from Bovine herpesvirus 1." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0001425
    obo:IAO_0000115 "A bacterial gene that is from Yersinia enterocolitica." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Yersinia enterocolitica gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_150052
    ] .

obo:VO_0001426
    obo:IAO_0000115 "A bacterial gene that is from Yersinia pestis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Yersinia pestis gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0001427
    obo:IAO_0000115 "A bacterial gene that is from Yersinia pseudotuberculosis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Yersinia pseudotuberculosis gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_633
    ] .

obo:VO_0001428
    obo:IAO_0000115 "A bacterial gene that is from Yersinia ruckeri." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Yersinia ruckeri gene"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_29486
    ] .

obo:VO_0001429
    obo:IAO_0000115 "A viral gene that is from Bovine Respiratory Syncytial Virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0001430
    obo:IAO_0000115 "A viral gene that is from Classical swine fever virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Classical swine fever virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0001431
    obo:IAO_0000115 "A viral gene that is from Equid herpesvirus 1." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Equid herpesvirus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10326
    ] .

obo:VO_0001432
    obo:IAO_0000115 "A viral gene that is from Feline herpesvirus 1." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Feline herpesvirus 1 gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10334
    ] .

obo:VO_0001433
    obo:IAO_0000115 "A viral gene that is from Feline immunodeficiency virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Feline immunodeficiency virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11673
    ] .

obo:VO_0001434
    obo:IAO_0000115 "A viral gene that is from Feline infectious peritonitis virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Feline infectious peritonitis virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11135
    ] .

obo:VO_0001435
    obo:IAO_0000115 "A viral gene that is from Gallid herpesvirus 1." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Gallid herpesvirus 1 gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0001436
    obo:IAO_0000115 "A viral gene that is from Hepatitis B virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Hepatitis B virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0001437
    obo:IAO_0000115 "A viral gene that is from Human herpesvirus 1." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Human herpesvirus 1 gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0001438
    obo:IAO_0000115 "A viral gene that is from Human metapneumovirus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Human metapneumovirus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_162145
    ] .

obo:VO_0001439
    obo:IAO_0000115 "A viral gene that is from Human Respiratory Syncytial Virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Human Respiratory Syncytial Virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11250
    ] .

obo:VO_0001440
    obo:IAO_0000115 "A viral gene that is from Infectious Hematopoietic Necrosis Virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Infectious Hematopoietic Necrosis Virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11290
    ] .

obo:VO_0001441
    obo:IAO_0000115 "A viral gene that is from Porcine respiratory and reproductive syndrome virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Porcine respiratory and reproductive syndrome virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0001442
    obo:IAO_0000115 "A viral gene that is from Pseudorabies virus." ;
    obo:IAO_0000117 "YH, RR" ;
    obo:IAO_0000118 "Suid herpesvirus 1 gene" ;
    a owl:Class ;
    rdfs:label "Pseudorabies virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0001443
    obo:IAO_0000115 "A viral gene that is from Rabies virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Rabies virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0001444
    obo:IAO_0000115 "A viral gene that is from SARS-CoV." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "SARS-CoV gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0001445
    obo:IAO_0000115 "A viral gene that is from Simian Immunodeficiency Virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Simian Immunodeficiency Virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11723
    ] .

obo:VO_0001446
    obo:IAO_0000115 "A viral gene that is from Tick-borne Encephalitis Virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Tick-borne Encephalitis Virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11084
    ] .

obo:VO_0001447
    obo:IAO_0000115 "A viral gene that is from VEE Virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "VEE Virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0001448
    obo:IAO_0000115 "A viral gene that is from West Nile virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "West Nile virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0001449
    obo:IAO_0000115 "A viral gene that is from Western equine encephalomyelitis virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Western equine encephalomyelitis virus gene"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_11039
    ] .

obo:VO_0001450
    obo:IAO_0000115 "A protozoan gene that is from Leishmania donovani." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Leishmania donovani gene"@en ;
    rdfs:subClassOf obo:VO_0000174, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0001451
    obo:IAO_0000115 "A Plasmodium gene that is from Plasmodium berghei." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Plasmodium berghei gene"@en ;
    rdfs:subClassOf obo:VO_0000171, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_5821
    ] .

obo:VO_0001452
    obo:IAO_0000115 "A Plasmodium gene that is from Plasmodium yoelii." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Plasmodium yoelii gene"@en ;
    rdfs:subClassOf obo:VO_0000171, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_5861
    ] .

obo:VO_0001453
    obo:IAO_0000115 "A protozoan gene that is from Toxoplasma gondii." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Toxoplasma gondii gene"@en ;
    rdfs:subClassOf obo:VO_0000170, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0001454
    obo:IAO_0000115 "A viral gene that is from Human herpesvirus 2." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "'Human herpesvirus 2 gene'"@en ;
    rdfs:subClassOf obo:VO_0000156, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_10310
    ] .

obo:VO_0001455
    obo:IAO_0000115 "A viral vaccine that protects against infection with Rinderpest virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "rinderpest virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11241
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11241
    ] .

obo:VO_0001456
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Erysipelothrix rhusiopathiae infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Erysipelothrix rhusiopathiae vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ] .

obo:VO_0001457
    obo:IAO_0000115 "protozoan vaccine that is used to protect against Tritrichomonas suis infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Trichomonas foetus vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_56690
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_56690
    ] .

obo:VO_0001458
    dc:creator "YL" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "International Duck Research Cooperative, Inc." ;
    rdfs:seeAlso "http://www.duckhealth.com/idrc.html" .

obo:VO_0001459
    obo:IAO_0000115 "protozoan vaccine that is used to protect against Eimeria spp. (Eimeria) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Eimeria spp. vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5800
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5800
    ] .

obo:VO_0001460
    obo:IAO_0000115 "viral vaccine that is used to protect against Orf Virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Orf Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10258
    ] .

obo:VO_0001461
    obo:IAO_0000115 "Vaccine that used for immunizing Aves."@en ;
    dc:creator "YL." ;
    a owl:Class ;
    rdfs:label "Aves vaccine" ;
    rdfs:subClassOf obo:VO_0001218, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8782
    ] .

obo:VO_0001462
    obo:IAO_0000115 "vaccine that used for immunizing fishes"@en ;
    dc:creator "YL."@en ;
    a owl:Class ;
    rdfs:label "fish vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001463
    obo:IAO_0000115 "viral vaccine that is used to protect against Fowlpox virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    obo:IAO_0000118 "Fowl pox vaccine" ;
    a owl:Class ;
    rdfs:label "Fowlpox virus vaccine" ;
    rdfs:subClassOf obo:VO_0000512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10261
    ] .

obo:VO_0001464
    obo:IAO_0000115 "vaccine that used for immunizing carnivora."@en ;
    dc:creator "YL"@en ;
    a owl:Class ;
    rdfs:label "carnivora vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001465
    obo:IAO_0000115 "vaccine that used for immunizing cat (felis catus)"@en ;
    a owl:Class ;
    rdfs:label "cat vaccine" ;
    rdfs:subClassOf obo:VO_0001464 .

obo:VO_0001466
    a owl:Class ;
    rdfs:label "cattle vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001467
    a owl:Class ;
    rdfs:label "dog vaccine" ;
    rdfs:subClassOf obo:VO_0001464 .

obo:VO_0001468
    a owl:Class ;
    rdfs:label "chicken vaccine" ;
    rdfs:subClassOf obo:VO_0000390 .

obo:VO_0001469
    a owl:Class ;
    rdfs:label "Ducks vaccine" ;
    rdfs:subClassOf obo:VO_0001461 .

obo:VO_0001470
    a owl:Class ;
    rdfs:label "catfish vaccine" ;
    rdfs:subClassOf obo:VO_0001462 .

obo:VO_0001471
    a owl:Class ;
    rdfs:label "gray wolf vaccine" ;
    rdfs:subClassOf obo:VO_0001464 .

obo:VO_0001472
    a owl:Class ;
    rdfs:label "horse vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001473
    a owl:Class ;
    rdfs:label "parrot vaccine" ;
    rdfs:subClassOf obo:VO_0001461 .

obo:VO_0001474
    a owl:Class ;
    rdfs:label "pig vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001475
    a owl:Class ;
    rdfs:label "sei whale vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001476
    a owl:Class ;
    rdfs:label "sheep vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001477
    obo:IAO_0000115 "vaccine that used for immunizing  salmoninae (tourts, salmons & chars )"@en ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "salmoninae vaccine" ;
    rdfs:subClassOf obo:VO_0001218 .

obo:VO_0001478
    a owl:Class ;
    rdfs:label "turkey vaccine" ;
    rdfs:subClassOf obo:VO_0001461 .

obo:VO_0001479
    obo:IAO_0000115 "The objective that intends to produce vaccine via the vaccine preparation process." ;
    dc:creator "YH" ;
    a owl:Class ;
    rdfs:label "vaccine target specification" ;
    rdfs:subClassOf obo:IAO_0000005 .

obo:VO_0001480
    obo:IAO_0000115 "A viral vaccine that protects against infection with African horse sickness virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "African horse sickness virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40050
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40050
    ] .

obo:VO_0001481
    obo:IAO_0000115 "viral vaccine that is used to protect against Pigeonpox virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pigeonpox virus vaccine" ;
    rdfs:subClassOf obo:VO_0000512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10264
    ] .

obo:VO_0001482
    obo:IAO_0000115 "viral vaccine that is used to protect against Bovine herpesvirus 1 infection" ;
    obo:IAO_0000117 "YL, YH" ;
    obo:IAO_0000118 "BHV-1 vaccine", "Bovine rhinotracheitis vaccine" ;
    a owl:Class ;
    rdfs:label "bovine herpesvirus 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10320
            ]
        )
    ] .

obo:VO_0001483
    obo:IAO_0000115 "A viral vaccine that protects against infection with Borna disease virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Borna disease virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12455
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12455
    ] .

obo:VO_0001484
    obo:IAO_0000115 "A viral vaccine that protects against infection with Caprine herpesvirus 1" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Caprine herpesvirus 1 vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_39944
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_39944
    ] .

obo:VO_0001485
    obo:IAO_0000115 "A vaccine licensed in the USA" ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm093833.htm" ;
    a owl:Class ;
    rdfs:label "USA licensed vaccine" ;
    rdfs:subClassOf obo:VO_0000363 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001486
    obo:IAO_0000115 "viral vaccine that is used to protect against Equid herpesvirus 1 infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equid herpesvirus 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10326
            ]
        )
    ] .

obo:VO_0001487
    obo:IAO_0000115 "viral vaccine that is used to protect against Feline herpesvirus 1 (Felid herpesvirus 1) infection" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "Feline herpesvirus 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10334
    ] .

obo:VO_0001488
    obo:IAO_0000115 "viral vaccine that is used to protect against Gallid herpesvirus 1 infection" ;
    obo:IAO_0000117 "YL, YH, RS, NF" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Gallid_herpesvirus_1" ;
    a owl:Class ;
    rdfs:label "Gallid herpesvirus 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0001489
    obo:IAO_0000115 "viral vaccine that is used to protect against Canine adenovirus type 1 (Canine adenovirus 1) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "canine adenovirus type 1  vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10512
    ] .

obo:VO_0001490
    obo:IAO_0000115 "viral vaccine that is used to protect against Canine Adenovirus Type 2 (Canine adenovirus 2) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "canine adenovirus Type 2 vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10514
    ] .

obo:VO_0001491
    obo:IAO_0000115 "viral vaccine that is used to protect against Bovine papillomavirus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine papillomavirus vaccine" ;
    rdfs:subClassOf obo:VO_0000748, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10571
    ] .

obo:VO_0001492
    obo:IAO_0000115 "viral vaccine that is used to protect against Avian Polyomavirus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian polyomavirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10625
    ] .

obo:VO_0001493
    obo:IAO_0000115 "viral vaccine that is used to protect against Mink enteritis virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink enteritis virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10792
    ] .

obo:VO_0001494
    obo:IAO_0000115 "viral vaccine that is used to protect against Porcine parvovirus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine parvovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10796
            ]
        )
    ] .

obo:VO_0001495
    obo:IAO_0000115 "viral vaccine that is used to protect against Porcine rotavirus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine rotavirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10913
    ] .

obo:VO_0001496
    obo:IAO_0000115 "viral vaccine that is used to protect against Equine rotavirus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine rotavirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10937
    ] .

obo:VO_0001497
    obo:IAO_0000115 "viral vaccine that is used to protect against Infectious Bursal Disease Virus (IBDV) infection" ;
    obo:IAO_0000117 "YL, YH, RS, NF" ;
    obo:IAO_0000118 "IBDV vaccine" ;
    a owl:Class ;
    rdfs:label "infectious bursal disease virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10995
            ]
        )
    ] .

obo:VO_0001498
    obo:IAO_0000115 "viral vaccine that is used to protect against Eastern Equine Encephalitis Virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Eastern Equine Encephalitis Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11021
            ]
        )
    ] .

obo:VO_0001499
    obo:IAO_0000115 "viral vaccine that is used to protect against VEE Virus (Venezuelan equine encephalitis virus) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "VEE Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11036
            ]
        )
    ] .

obo:VO_0001500
    obo:IAO_0000115 "viral vaccine that is used to protect against Equine arteritis virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine arteritis virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11047
    ] .

obo:VO_0001501
    obo:IAO_0000115 "viral vaccine that is used to protect against Bovine viral diarrhea virus 1 infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine viral diarrhea virus 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ] .

obo:VO_0001502
    obo:IAO_0000115 "viral vaccine that is used to protect against Infectious Bronchitis Virus (IBV) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Infectious Bronchitis Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11120
            ]
        )
    ] .

obo:VO_0001503
    obo:IAO_0000115 "viral vaccine that is used to protect against Bovine coronavirus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "bovine coronavirus vaccine" ;
    rdfs:subClassOf obo:VO_0004897 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11128
    ] .

obo:VO_0001504
    obo:IAO_0000115 "viral vaccine that is used to protect against Feline infectious peritonitis virus infection" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "Feline infectious peritonitis virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11135
    ] .

obo:VO_0001505
    obo:IAO_0000115 "viral vaccine that is used to protect against Transmissible gastroenteritis virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Transmissible gastroenteritis virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11149
    ] .

obo:VO_0001506
    obo:IAO_0000115 "viral vaccine that is used to protect against Bovine Parainfluenza 3 Virus (BPIV-3) (Bovine parainfluenza virus 3) infection" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "Bovine Parainfluenza 3 Virus vaccine" ;
    rdfs:subClassOf obo:VO_0002485 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000451
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11215
            ]
        )
    ] .

obo:VO_0001507
    obo:IAO_0000115 "viral vaccine that is used to protect against Bovine Respiratory Syncytial Virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0001508
    obo:IAO_0000115 "viral vaccine that is used to protect against Feline immunodeficiency virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline immunodeficiency virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11673
    ] .

obo:VO_0001509
    obo:IAO_0000115 "viral vaccine that is used to protect against Feline calicivirus infection" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "Feline calicivirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11978
    ] .

obo:VO_0001510
    obo:IAO_0000115 "viral vaccine that is used to protect against Chicken Anemia Virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "chicken anemia virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12618
    ] .

obo:VO_0001511
    obo:IAO_0000115 "viral vaccine that is used to protect against Porcine respiratory and reproductive syndrome virus (Porcine reproductive and respiratory syndrome virus) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine respiratory and reproductive syndrome virus  vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0001512
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Riemerella anatipestifer infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Riemerella anatipestifer vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_34085
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_34085
    ] .

obo:VO_0001513
    obo:IAO_0000115 "viral vaccine that is used to protect against Avian Reovirus (Avian orthoreovirus) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian reovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ] .

obo:VO_0001514
    obo:IAO_0000115 "viral vaccine that is used to protect against Avian pneumovirus (Avian metapneumovirus) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian pneumovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38525
    ] .

obo:VO_0001515
    obo:IAO_0000115 "viral vaccine that is used to protect against Bluetongue virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bluetongue virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40051
    ] .

obo:VO_0001516
    obo:IAO_0000115 "viral vaccine that is used to protect against Turkey hemorrhagic enteritis virus (Turkey adenoirus 3) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Turkey hemorrhagic enteritis virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_41678
    ] .

obo:VO_0001517
    obo:IAO_0000115 "viral vaccine that is used to protect against Canarypox virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canarypox virus vaccine" ;
    rdfs:subClassOf obo:VO_0000512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_44088
    ] .

obo:VO_0001518
    obo:IAO_0000115 "viral vaccine that is used to protect against Psittacid herpesvirus 1 infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Psittacid herpesvirus 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_50294
    ] .

obo:VO_0001519
    obo:IAO_0000115 "A vaccine that protects against infection with Mycobacterium bovis" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Mycobacterium bovis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000592, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1765
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1765
    ] .

obo:VO_0001520
    obo:IAO_0000115 "viral vaccine that is used to protect against Infectious salmon anemia virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Infectious salmon anemia virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_55987
    ] .

obo:VO_0001521
    obo:IAO_0000115 "An Edwardsiella bacterial vaccine that is used to protect against Edwardsiella ictaluri infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Edwardsiella ictaluri vaccine" ;
    rdfs:subClassOf obo:VO_0000602, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_67780
    ] .

obo:VO_0001522
    obo:IAO_0000115 "viral vaccine that is used to protect against Avian Encephalomyelitis Virus infection" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "avian encephalomyelitis virus vaccine" ;
    rdfs:seeAlso "SNOMEDCT: 35283005; UMLS_CUI:C0310667" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_70796
    ] .

obo:VO_0001523
    obo:IAO_0000115 "bacterial vaccine that is used to protect against Mannheimia haemolytica infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mannheimia haemolytica vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0001524
    obo:IAO_0000115 "viral vaccine that is used to protect against Porcine circovirus 2 infection" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "porcine circovirus 2 vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_85708
            ]
        )
    ] .

obo:VO_0001525
    obo:IAO_0000115 "viral vaccine that is used to protect against Duck enteritis virus (Anatid herpesvirus 1) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Duck enteritis virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_104388
    ] .

obo:VO_0001526
    obo:IAO_0000115 "viral vaccine that is used to protect against Canine parainfluenza virus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "canine parainfluenza virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_149595
            ]
        )
    ] .

obo:VO_0001527
    obo:IAO_0000115 "viral vaccine that is used to protect against Avian Paramyxovirus infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian paramyxovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_260963
    ] .

obo:VO_0001528
    obo:IAO_0000115 "viral vaccine that is used to protect against Duck hepatitis virus 1 (Duck hepatitis A virus) infection" ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Duck hepatitis virus 1 vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_691956
    ] .

obo:VO_0001529
    dc:creator "YL" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:comment """Vaccicel, Inc. has a location in Belton, TX. Active officers include Andre Menchu, Andres Menchu, Kathryn M Baker, Katheryn Becker and Andres Menches. Vaccicel, Inc. filed as a Domestic For-Profit Corporation on Tuesday, August 22, 1995 in the state of Texas and is currently active. Andres Menchu serves as the registered agent for this organization.The company's line of business includes Mfg Research & Development Veterinary Bacterial Vaccines. 
(http://www.corporationwiki.com/Texas/Belton/vaccicel-inc/34296230.aspx)""" ;
    rdfs:label "VacciCel, Inc." .

obo:VO_0001530
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canary Pox Modified Live Virus Vaccine (USDA: 1623.10)" ;
    rdfs:seeAlso "USDA: 1623.10", "violinID:1557" ;
    rdfs:subClassOf obo:VO_0001517, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8825
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001531
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pigeon Pox Live Virus Vaccine (USDA: 1881.10)" ;
    rdfs:seeAlso "USDA: 1881.10", "violinID:2092" ;
    rdfs:subClassOf obo:VO_0001481, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8825
    ] .

obo:VO_0001532
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pigeon Pox Live Virus Vaccine (USDA: 1881.12)" ;
    rdfs:seeAlso "USDA: 1881.12", "violinID:2093" ;
    rdfs:subClassOf obo:VO_0001481, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8825
    ] .

obo:VO_0001533
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pigeon Pox Live Virus Vaccine (USDA: 1881.14)" ;
    rdfs:seeAlso "USDA: 1881.14", "violinID:2094" ;
    rdfs:subClassOf obo:VO_0001481, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8825
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001534
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Quail Pox Live Virus Vaccine (USDA: 18E1.10)" ;
    rdfs:seeAlso "USDA: 18E1.10", "violinID:2111" ;
    rdfs:subClassOf obo:VO_0000513, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8825
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001535
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fox Encephalitis Killed Virus Vaccine (USDA: 1635.20)" ;
    rdfs:seeAlso "USDA: 1635.20", "violinID:1925" ;
    rdfs:subClassOf obo:VO_0001489, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_33554
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10512
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001536
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper Modified Live Virus Vaccine (USDA: 1451.00)" ;
    rdfs:seeAlso "USDA: 1451.00", "violinID:1967" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_33554
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001537
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper Modified Live Virus Vaccine (USDA: 1451.01)" ;
    rdfs:seeAlso "USDA: 1451.01", "violinID:1968" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_33554
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001538
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper Modified Live Virus Vaccine (USDA: 1451.20)" ;
    rdfs:seeAlso "USDA: 1451.20", "violinID:1969" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_33554
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001539
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Enteritis Vaccine" ;
    rdfs:seeAlso "violinID:1972" ;
    rdfs:subClassOf obo:VO_0001493, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_33554
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10792
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001540
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline calicivirus Killed Virus Vaccine (USDA: 15C5.21)" ;
    rdfs:seeAlso "USDA: 15C5.21", "violinID:1766" ;
    rdfs:subClassOf obo:VO_0001509, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001541
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline calicivirus Modified Live Virus Vaccine (USDA: 15C1.22)" ;
    rdfs:seeAlso "USDA: 15C1.22", "violinID:1765" ;
    rdfs:subClassOf obo:VO_0001509, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001542
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline immunodeficiency virus Killed Virus Vaccine (USDA: 15A5.21)" ;
    rdfs:seeAlso "USDA: 15A5.21", "violinID:1767" ;
    rdfs:subClassOf obo:VO_0001508, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11673
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001543
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline immunodeficiency virus Killed Virus Vaccine (USDA: 15A5.23)" ;
    rdfs:seeAlso "USDA: 15A5.23", "violinID:1768" ;
    rdfs:subClassOf obo:VO_0001508, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11673
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001544
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Infectious Peritonitis Modified Live Virus Vaccine (USDA: 15A1.20)" ;
    rdfs:seeAlso "USDA: 15A1.20", "violinID:1771" ;
    rdfs:subClassOf obo:VO_0001504, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11135
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001545
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia Killed Virus Vaccine (USDA: 1555.20)" ;
    rdfs:seeAlso "USDA: 1555.20", "violinID:1772" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001546
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia Killed Virus Vaccine (USDA: 1555.21)" ;
    rdfs:seeAlso "USDA: 1555.21", "violinID:1773" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001547
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia Killed Virus Vaccine (USDA: 1555.22)" ;
    rdfs:seeAlso "USDA: 1555.22", "violinID:1774" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001548
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia Killed Virus Vaccine (USDA: 1555.R1)" ;
    rdfs:seeAlso "USDA: 1555.R1", "violinID:1775" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001549
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia Live Canarypox Vector Vaccine (USDA: 1555.R3)" ;
    rdfs:seeAlso "USDA: 1555.R3", "violinID:1776" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001550
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Panleukopenia Killed Virus Vaccine (USDA: 1565.20)" ;
    rdfs:seeAlso "USDA: 1565.20", "violinID:1819" ;
    rdfs:subClassOf obo:VO_0000389, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001551
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.00)" ;
    rdfs:seeAlso "USDA: 1561.00", "violinID:1815" ;
    rdfs:subClassOf obo:VO_0001021, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001552
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.20)" ;
    rdfs:seeAlso "USDA: 1561.20", "violinID:1816" ;
    rdfs:subClassOf obo:VO_0001021, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001553
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.21)" ;
    rdfs:seeAlso "USDA: 1561.21", "violinID:1817" ;
    rdfs:subClassOf obo:VO_0001021, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001554
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.23)" ;
    rdfs:seeAlso "USDA: 1561.23", "violinID:1818" ;
    rdfs:subClassOf obo:VO_0001021, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001555
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis Modified Live Virus Vaccine (USDA: 16A1.22)" ;
    rdfs:seeAlso "USDA: 16A1.22", "violinID:1820" ;
    rdfs:subClassOf obo:VO_0001487, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10334
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001556
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Edwardsiella ictaluri Avirulent Live Culture Vaccine (USDA: 1531.00)" ;
    rdfs:seeAlso "USDA: 1531.00", "violinID:1714" ;
    rdfs:subClassOf obo:VO_0001521, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_7995
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_67780
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001557
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Anthrax Spore live culture Vaccine (USDA: 1011.00)" ;
    rdfs:seeAlso "USDA: 1011.00", "violinID:1122" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001558
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.20)" ;
    rdfs:seeAlso "USDA: 1095.20", "violinID:1179" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0001559
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.21)" ;
    rdfs:seeAlso "USDA: 1095.21", "violinID:1180" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001560
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus Vaccine Modified Live Virus (USDA: 1091.20)" ;
    rdfs:seeAlso "USDA: 1091.20", "violinID:1178" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0001561
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Killed Virus Vaccine (USDA: 1105.20)" ;
    rdfs:seeAlso "USDA: 1105.20", "violinID:1186" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001562
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.00)" ;
    rdfs:seeAlso "USDA: 1101.00", "violinID:1181" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0001563
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.20)" ;
    rdfs:seeAlso "USDA: 1101.20", "violinID:1182" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000058 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0001564
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.21)" ;
    rdfs:seeAlso "USDA: 1101.21", "violinID:1183" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001565
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.22)" ;
    rdfs:seeAlso "USDA: 1101.22", "violinID:1184" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001566
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.B0)" ;
    rdfs:seeAlso "USDA: 1101.B0", "violinID:1185" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000059 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001567
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.00)" ;
    rdfs:seeAlso "USDA: 1205.00", "violinID:1354" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001568
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.20)" ;
    rdfs:seeAlso "USDA: 1205.20", "violinID:1355" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ] .

obo:VO_0001569
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.21)" ;
    rdfs:seeAlso "USDA: 1205.21", "violinID:1356" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ] .

obo:VO_0001570
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.22)" ;
    rdfs:seeAlso "USDA: 1205.22", "violinID:1357" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001571
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.25)" ;
    rdfs:seeAlso "USDA: 1205.25", "violinID:1358" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001572
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Modified Live Virus Vaccine (USDA: 1201.00)" ;
    rdfs:seeAlso "USDA: 1201.00", "violinID:1351" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ] .

obo:VO_0001573
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Modified Live Virus Vaccine (USDA: 1201.20)" ;
    rdfs:seeAlso "USDA: 1201.20", "violinID:1352" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000058 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ] .

obo:VO_0001574
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Modified Live Virus Vaccine (USDA: 1201.22)" ;
    rdfs:seeAlso "USDA: 1201.22", "violinID:1353" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001575
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Brucella Abortus Strain 19, Live Culture Vaccine (USDA: 1251.01)" ;
    rdfs:seeAlso "USDA: 1251.01", "violinID:1383" ;
    rdfs:subClassOf obo:VO_0000022, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001576
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Brucella Abortus Strain 19, Live Culture, Reduced Dose Vaccine (USDA: 1251.02)" ;
    rdfs:seeAlso "USDA: 1251.02", "violinID:1384" ;
    rdfs:subClassOf obo:VO_0000022, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001577
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Brucella Abortus Strain RB-51, Live Culture Vaccine (USDA: 1261.00)" ;
    rdfs:seeAlso "USDA: 1261.00", "violinID:1385" ;
    rdfs:subClassOf obo:VO_0000021, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001578
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1841.00)" ;
    rdfs:seeAlso "USDA: 1841.00", "violinID:2077" ;
    rdfs:subClassOf obo:VO_0001506, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001579
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1841.20)" ;
    rdfs:seeAlso "USDA: 1841.20", "violinID:2078" ;
    rdfs:subClassOf obo:VO_0001506, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001580
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Salmonella Choleraesuis Avirulent Live Culture Vaccine (USDA: 19A1.00)" ;
    rdfs:seeAlso "USDA: 19A1.00", "violinID:2121" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0001581
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Salmonella Choleraesuis Avirulent Live Culture Vaccine (USDA: 19A1.01)" ;
    rdfs:seeAlso "USDA: 19A1.01", "violinID:2122" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0001582
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Salmonella Dublin Live Culture Vaccine (USDA: 19D1.R0)" ;
    rdfs:seeAlso "USDA: 19D1.R0", "violinID:2123" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001583
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Trichomonas Foetus Killed Protozoa Vaccine (USDA: 1859.00)" ;
    rdfs:seeAlso "USDA: 1859.00", "violinID:2143" ;
    rdfs:subClassOf obo:VO_0001457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_56690
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001584
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    obo:IAO_0000118 "Wart Vaccine (Colorado Serum)" ;
    a owl:Class ;
    rdfs:label "Wart Killed Virus Vaccine (USDA: 1985.50)" ;
    rdfs:seeAlso "USDA: 1985.50", "violinID:2144" ;
    rdfs:subClassOf obo:VO_0001491, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10571
    ] .

obo:VO_0001585
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis Killed Virus Vaccine (USDA: 1015.I0)" ;
    rdfs:seeAlso "USDA: 1015.I0", "violinID:1124" ;
    rdfs:subClassOf obo:VO_0001522, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_70796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000059 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001586
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis Live Virus Vaccine (USDA: 1051.10)" ;
    rdfs:seeAlso "USDA: 1051.10", "violinID:1125" ;
    rdfs:subClassOf obo:VO_0001522, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_70796
    ] .

obo:VO_0001587
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis Live Virus Vaccine (USDA: 1051.11)" ;
    rdfs:seeAlso "USDA: 1051.11", "violinID:1126" ;
    rdfs:subClassOf obo:VO_0001522, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_70796
    ] .

obo:VO_0001588
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis Live Virus Vaccine (USDA: 1051.12)" ;
    rdfs:seeAlso "USDA: 1051.12", "violinID:1127" ;
    rdfs:subClassOf obo:VO_0001522, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_70796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001589
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H10N9 Subtype, Killed Virus Vaccine (USDA: 1057.H0)" ;
    rdfs:seeAlso "USDA: 1057.H0", "violinID:1147" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001590
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H2N2 Subtype, Killed Virus Vaccine (USDA: 1057.H2)" ;
    rdfs:seeAlso "USDA: 1057.H2", "violinID:1149" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001591
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H3N4 Subtype, Killed Virus Vaccine (USDA: 1057.H3)" ;
    rdfs:seeAlso "USDA: 1057.H3", "violinID:1150" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:VO_0000812
                obo:VO_0000864
            )
        ]
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001592
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H4N6 Subtype, Killed Virus Vaccine (USDA: 1057.H4)" ;
    rdfs:seeAlso "USDA: 1057.H4", "violinID:1151" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001593
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H5N2 Subtype, Killed Virus Vaccine (USDA: 1057.H5)" ;
    rdfs:seeAlso "USDA: 1057.H5", "violinID:1152" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001594
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H5N9 Subtype, Killed Virus Vaccine (USDA: 1057.14)" ;
    rdfs:seeAlso "USDA: 1057.14", "violinID:1146" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001595
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H6N8 Subtype, Killed Virus Vaccine (USDA: 1057.H6)" ;
    rdfs:seeAlso "USDA: 1057.H6", "violinID:1153" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001596
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H7N2 Subtype, Killed Virus Vaccine (USDA: 10F5.12)" ;
    rdfs:seeAlso "USDA: 10F5.12", "violinID:1158" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001597
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H7N3 Subtype, Killed Virus Vaccine (USDA: 1057.H7)" ;
    rdfs:seeAlso "USDA: 1057.H7", "violinID:1154" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001598
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza  H7N3 Subtype, Killed Virus Vaccine (USDA: 10F5.13)" ;
    rdfs:seeAlso "USDA: 10F5.13", "violinID:1159" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001599
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza H1N1 Subtype, Killed Virus Vaccine (USDA: 1057.H1)" ;
    rdfs:seeAlso "USDA: 1057.H1", "violinID:1148" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:VO_0000812
                obo:VO_0000864
            )
        ]
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001600
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza H5N2 Subtype, Killed Virus Vaccine (USDA: 10F5.10)" ;
    rdfs:seeAlso "USDA: 10F5.10", "violinID:1157" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001601
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza H5N3 Subtype, Killed Virus Vaccine (USDA: 1057.R3)" ;
    rdfs:seeAlso "USDA: 1057.R3", "violinID:1156" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001602
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza H9N2 Subtype, Killed Virus Vaccine (USDA: 1057.H9)" ;
    rdfs:seeAlso "USDA: 1057.H9", "violinID:1155" ;
    rdfs:subClassOf obo:VO_0001024, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001603
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Paramyxovirus Type 1, Killed Virus Vaccine (USDA: 10C5.11)" ;
    rdfs:seeAlso "USDA: 10C5.11", "violinID:1163" ;
    rdfs:subClassOf obo:VO_0001527, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_260963
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001604
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Paramyxovirus Type 3, Killed Virus Vaccine (USDA: 10C5.10)" ;
    rdfs:seeAlso "USDA: 10C5.10", "violinID:1162" ;
    rdfs:subClassOf obo:VO_0001527, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_260963
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001605
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Pneumovirus Modified Live Virus Vaccine (USDA: 1A31.20)" ;
    rdfs:seeAlso "USDA: 1A31.20", "violinID:1164" ;
    rdfs:subClassOf obo:VO_0001514, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001606
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Reovirus Killed Virus Vaccine (USDA: 1045.00)" ;
    rdfs:seeAlso "USDA: 1045.00", "violinID:1166" ;
    rdfs:subClassOf obo:VO_0001513, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ] .

obo:VO_0001607
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Reovirus Killed Virus Vaccine (USDA: 1045.01)" ;
    rdfs:seeAlso "USDA: 1045.01", "violinID:1167" ;
    rdfs:subClassOf obo:VO_0001513, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001608
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Reovirus Killed Virus Vaccine (USDA: 1045.02)" ;
    rdfs:seeAlso "USDA: 1045.02", "violinID:1168" ;
    rdfs:subClassOf obo:VO_0001513, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ] .

obo:VO_0001609
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Reovirus Killed Virus Vaccine (USDA: 1045.30)" ;
    rdfs:seeAlso "USDA: 1045.30", "violinID:1169" ;
    rdfs:subClassOf obo:VO_0001513, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001610
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis  Mass Type, Live Virus Vaccine (USDA: 1231.11)" ;
    rdfs:seeAlso "USDA: 1231.11", "violinID:1361" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001611
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.1M)" ;
    rdfs:seeAlso "USDA: 1231.1M", "violinID:1373" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001612
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.20)" ;
    rdfs:seeAlso "USDA: 1231.20", "violinID:1375" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001613
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.21)" ;
    rdfs:seeAlso "USDA: 1231.21", "violinID:1376" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001614
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.22)" ;
    rdfs:seeAlso "USDA: 1231.22", "violinID:1377" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001615
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Conn Type, Live Virus Vaccine (USDA: 1231.15)" ;
    rdfs:seeAlso "USDA: 1231.15", "violinID:1365" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001616
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Delaware Type, Modified Live Virus Vaccine (USDA: 1231.1D)" ;
    rdfs:seeAlso "USDA: 1231.1D", "violinID:1368" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001617
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Georgia Type, Live Virus Vaccine (USDA: 1231.1J)" ;
    rdfs:seeAlso "USDA: 1231.1J", "violinID:1371" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001618
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Georgia Type, Live Virus Vaccine (USDA: 1231.1L)" ;
    rdfs:seeAlso "USDA: 1231.1L", "violinID:1372" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001619
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1235.15)" ;
    rdfs:seeAlso "USDA: 1235.15", "violinID:1382" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001620
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass & Ark Types, Live Virus Vaccine (USDA: 1231.13)" ;
    rdfs:seeAlso "USDA: 1231.13", "violinID:1363" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001621
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass & Conn Types, Live Virus Vaccine (USDA: 1231.14)" ;
    rdfs:seeAlso "USDA: 1231.14", "violinID:1364" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001622
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass & Conn Types, Live Virus Vaccine (USDA: 1231.1G)" ;
    rdfs:seeAlso "USDA: 1231.1G", "violinID:1370" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001623
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass & Conn Types, Live Virus Vaccine (USDA:1231.1N)" ;
    rdfs:seeAlso "USDA:1231.1N", "violinID:1374" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001624
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.12)" ;
    rdfs:seeAlso "USDA: 1231.12", "violinID:1362" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001625
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.18)" ;
    rdfs:seeAlso "USDA: 1231.18", "violinID:1366" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001626
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.1A)" ;
    rdfs:seeAlso "USDA: 1231.1A", "violinID:1367" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001627
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.1F)" ;
    rdfs:seeAlso "USDA: 1231.1F", "violinID:1369" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001628
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1232.10)" ;
    rdfs:seeAlso "USDA: 1232.10", "violinID:1378" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001629
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1232.15)" ;
    rdfs:seeAlso "USDA: 1232.15", "violinID:1379" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001630
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1233.10)" ;
    rdfs:seeAlso "USDA: 1233.10", "violinID:1380" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001631
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bronchitis Mass Type, Live Virus Vaccine (USDA: 1235.10)" ;
    rdfs:seeAlso "USDA: 1235.10", "violinID:1381" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001632
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Killed Virus Vaccine (USDA: 1275.00)" ;
    rdfs:seeAlso "USDA: 1275.00", "violinID:1403" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001633
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Killed Virus Vaccine (USDA: 1275.02)" ;
    rdfs:seeAlso "USDA: 1275.02", "violinID:1404" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001634
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Killed Virus Vaccine (USDA: 1275.20)" ;
    rdfs:seeAlso "USDA: 1275.20", "violinID:1405" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001635
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.00)" ;
    rdfs:seeAlso "USDA: 1271.00", "violinID:1386" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001636
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.01)" ;
    rdfs:seeAlso "USDA: 1271.01", "violinID:1387" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001637
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.02)" ;
    rdfs:seeAlso "USDA: 1271.02", "violinID:1388" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001638
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.04)" ;
    rdfs:seeAlso "USDA: 1271.04", "violinID:1389" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001639
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.0A)" ;
    rdfs:seeAlso "USDA: 1271.0A", "violinID:1390" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001640
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.10)" ;
    rdfs:seeAlso "USDA: 1271.10", "violinID:1391" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001641
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.11)" ;
    rdfs:seeAlso "USDA: 1271.11", "violinID:1392" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001642
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.12)" ;
    rdfs:seeAlso "USDA: 1271.12", "violinID:1393" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001643
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.13)" ;
    rdfs:seeAlso "USDA: 1271.13", "violinID:1394" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001644
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.16)" ;
    rdfs:seeAlso "USDA: 1271.16", "violinID:1396" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001645
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.17)" ;
    rdfs:seeAlso "USDA: 1271.17", "violinID:1397" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001646
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.18)" ;
    rdfs:seeAlso "USDA: 1271.18", "violinID:1398" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001647
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.19)" ;
    rdfs:seeAlso "USDA: 1271.19", "violinID:1399" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001648
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.40)" ;
    rdfs:seeAlso "USDA: 1271.40", "violinID:1400" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001649
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1271.41)" ;
    rdfs:seeAlso "USDA: 1271.41", "violinID:1401" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001650
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Live Virus Vaccine (USDA: 1272.00)" ;
    rdfs:seeAlso "USDA: 1272.00", "violinID:1402" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001651
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Modified Live VirusVaccine (USDA: 1271.15)" ;
    rdfs:seeAlso "USDA: 1271.15", "violinID:1395" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001652
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.01)" ;
    rdfs:seeAlso "USDA: 12B5.01", "violinID:1409" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001653
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.40)" ;
    rdfs:seeAlso "USDA: 12B5.40", "violinID:1410" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001654
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.41)" ;
    rdfs:seeAlso "USDA: 12B5.41", "violinID:1411" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001655
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.4A)" ;
    rdfs:seeAlso "USDA: 12B5.4A", "violinID:1412" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001656
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Standard & Variant, Live Virus Vaccine (USDA: 12B1.00)" ;
    rdfs:seeAlso "USDA: 12B1.00", "violinID:1407" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001657
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Standard & Variant, Live Virus Vaccine (USDA: 12B1.01)" ;
    rdfs:seeAlso "USDA: 12B1.01", "violinID:1408" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001658
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Variant, Killed Virus Vaccine (USDA: 12A5.00)" ;
    rdfs:seeAlso "USDA: 12A5.00", "violinID:1406" ;
    rdfs:subClassOf obo:VO_0000960, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001659
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease Variant, Live Virus Vaccine (USDA: 12L1.00)" ;
    rdfs:seeAlso "USDA: 12L1.00", "violinID:1413" ;
    rdfs:subClassOf obo:VO_0000961, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001660
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Chicken Anemia Virus Live Virus Vaccine (USDA: 10A1.00)" ;
    rdfs:seeAlso "USDA: 10A1.00", "violinID:1697" ;
    rdfs:subClassOf obo:VO_0001510, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12618
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001661
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Chicken Anemia Virus Live Virus Vaccine (USDA: 10A1.01)" ;
    rdfs:seeAlso "USDA: 10A1.01", "violinID:1698" ;
    rdfs:subClassOf obo:VO_0001510, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12618
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001662
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Chicken Anemia Virus Modified Live Virus Vaccine (USDA: 10A1.10)" ;
    rdfs:seeAlso "USDA: 10A1.10", "violinID:1699" ;
    rdfs:subClassOf obo:VO_0001510, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12618
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001663
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts Vaccine (USDA: 1431.50)" ;
    rdfs:seeAlso "USDA: 1431.50", "violinID:1702" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000821 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001664
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts Vaccine (USDA: 1431.51)" ;
    rdfs:seeAlso "USDA: 1431.51", "violinID:1703" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001665
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts Vaccine (USDA: 1431.56)" ;
    rdfs:seeAlso "USDA: 1431.56", "violinID:1705" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000821 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001666
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts Vaccine (USDA: 1431.57)" ;
    rdfs:seeAlso "USDA: 1431.57", "violinID:1706" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001667
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts Vaccine (USDA: 1431.58)" ;
    rdfs:seeAlso "USDA: 1431.58", "violinID:1707" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000989 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001668
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts Vaccine (USDA: 1431.59)" ;
    rdfs:seeAlso "USDA: 1431.59", "violinID:1708" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000989 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001669
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts Vaccine (USDA: 1431.5C)" ;
    rdfs:seeAlso "USDA: 1431.5C", "violinID:1709" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001670
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Coccidiosis Live Oocysts, Chicken Isolates Vaccine (USDA: 1431.55)" ;
    rdfs:seeAlso "USDA: 1431.55", "violinID:1704" ;
    rdfs:subClassOf obo:VO_0000906, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001671
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.01)" ;
    rdfs:seeAlso "USDA: 1601.01", "violinID:1903" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001672
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.02)" ;
    rdfs:seeAlso "USDA: 1601.02", "violinID:1904" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001673
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.11)" ;
    rdfs:seeAlso "USDA: 1601.11", "violinID:1905" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001674
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.13)" ;
    rdfs:seeAlso "USDA: 1601.13", "violinID:1906" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001675
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.14)" ;
    rdfs:seeAlso "USDA: 1601.14", "violinID:1907" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001676
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.15)" ;
    rdfs:seeAlso "USDA: 1601.15", "violinID:1908" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001677
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox Live Virus Vaccine (USDA: 1621.00)" ;
    rdfs:seeAlso "USDA: 1621.00", "violinID:1913" ;
    rdfs:subClassOf obo:VO_0001463, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001678
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox Live Virus Vaccine (USDA: 1621.10)" ;
    rdfs:seeAlso "USDA: 1621.10", "violinID:1914" ;
    rdfs:subClassOf obo:VO_0001463, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001679
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox Live Virus Vaccine (USDA: 1621.11)" ;
    rdfs:seeAlso "USDA: 1621.11", "violinID:1915" ;
    rdfs:subClassOf obo:VO_0001463, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001680
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox Live Virus Vaccine (USDA: 1621.13)" ;
    rdfs:seeAlso "USDA: 1621.13", "violinID:1916" ;
    rdfs:subClassOf obo:VO_0001463, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001681
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox Live Virus Vaccine (USDA: 1621.14)" ;
    rdfs:seeAlso "USDA: 1621.14", "violinID:1917" ;
    rdfs:subClassOf obo:VO_0001463, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001682
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox Live Virus Vaccine (USDA: 1622.00)" ;
    rdfs:seeAlso "USDA: 1622.00", "violinID:1918" ;
    rdfs:subClassOf obo:VO_0001463, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001683
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.00)" ;
    rdfs:seeAlso "USDA: 16L1.00", "violinID:1945" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001684
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.04)" ;
    rdfs:seeAlso "USDA: 16L1.04", "violinID:1948" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001685
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.09)" ;
    rdfs:seeAlso "USDA: 16L1.09", "violinID:1952" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001686
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 2, Live Virus Vaccine (USDA: 1631.00)" ;
    rdfs:seeAlso "USDA: 1631.00", "violinID:1934" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001687
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.00)" ;
    rdfs:seeAlso "USDA: 1641.00", "violinID:1936" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001688
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.01)" ;
    rdfs:seeAlso "USDA: 1641.01", "violinID:1937" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001689
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.06)" ;
    rdfs:seeAlso "USDA: 1641.06", "violinID:1938" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001690
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 16L1.06)" ;
    rdfs:seeAlso "USDA: 16L1.06", "violinID:1949" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001691
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 1 & 2 & 3, Live Virus Vaccine (USDA: 16L1.01)" ;
    rdfs:seeAlso "USDA: 16L1.01", "violinID:1946" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001692
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 1 & 3, Live Herpesvirus Chimera Vaccine (USDA: 1631.R0)" ;
    rdfs:seeAlso "USDA: 1631.R0", "violinID:1935" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001693
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16G1.02)" ;
    rdfs:seeAlso "USDA: 16G1.02", "violinID:1944" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001694
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.02)" ;
    rdfs:seeAlso "USDA: 16L1.02", "violinID:1947" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001695
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.08)" ;
    rdfs:seeAlso "USDA: 16L1.08", "violinID:1951" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001696
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.00)" ;
    rdfs:seeAlso "USDA: 1651.00", "violinID:1939" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001697
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.01)" ;
    rdfs:seeAlso "USDA: 1651.01", "violinID:1940" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001698
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.02)" ;
    rdfs:seeAlso "USDA: 1651.02", "violinID:1941" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001699
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.05)" ;
    rdfs:seeAlso "USDA: 1651.05", "violinID:1942" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001700
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16G1.00)" ;
    rdfs:seeAlso "USDA: 16G1.00", "violinID:1943" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001701
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16L1.07)" ;
    rdfs:seeAlso "USDA: 16L1.07", "violinID:1950" ;
    rdfs:subClassOf obo:VO_0001017, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001702
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mycoplasma Gallisepticum Live Culture Vaccine (USDA: 1751.00)" ;
    rdfs:seeAlso "USDA: 1751.00", "violinID:1973" ;
    rdfs:subClassOf obo:VO_0000949, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001703
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mycoplasma Gallisepticum Live Culture Vaccine (USDA: 1751.01)" ;
    rdfs:seeAlso "USDA: 1751.01", "violinID:1974" ;
    rdfs:subClassOf obo:VO_0000949, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2096
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001704
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.10)" ;
    rdfs:seeAlso "USDA: 1711.10", "violinID:1981" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001705
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.12)" ;
    rdfs:seeAlso "USDA: 1711.12", "violinID:1982" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001706
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.14)" ;
    rdfs:seeAlso "USDA: 1711.14", "violinID:1983" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001707
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.18)" ;
    rdfs:seeAlso "USDA: 1711.18", "violinID:1984" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001708
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 17A2.10)" ;
    rdfs:seeAlso "USDA: 17A2.10", "violinID:1991" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001709
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, C2 Strain, Live VirusVaccine (USDA: 17B1.10)" ;
    rdfs:seeAlso "USDA: 17B1.10", "violinID:1993" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001710
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.0A)" ;
    rdfs:seeAlso "USDA: 1721.0A", "violinID:1985" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001711
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.10)" ;
    rdfs:seeAlso "USDA: 1721.10", "violinID:1986" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001712
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.11)" ;
    rdfs:seeAlso "USDA: 1721.11", "violinID:1987" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001713
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.15)" ;
    rdfs:seeAlso "USDA: 1721.15", "violinID:1988" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001714
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.16)" ;
    rdfs:seeAlso "USDA: 1721.16", "violinID:1989" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001715
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.17)" ;
    rdfs:seeAlso "USDA: 1721.17", "violinID:1990" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001716
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease Killed Virus Vaccine (USDA: 1705.10)" ;
    rdfs:seeAlso "USDA: 1705.10", "violinID:1977" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001717
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease Killed Virus Vaccine (USDA: 1705.11)" ;
    rdfs:seeAlso "USDA: 1705.11", "violinID:1978" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001718
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease Killed Virus Vaccine (USDA: 1705.13)" ;
    rdfs:seeAlso "USDA: 1705.13", "violinID:1979" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001719
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease Killed Virus Vaccine (USDA: 1705.15)" ;
    rdfs:seeAlso "USDA: 1705.15", "violinID:1980" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001720
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 1701.10)" ;
    rdfs:seeAlso "USDA: 1701.10", "violinID:1976" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001721
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 17A2.V1)" ;
    rdfs:seeAlso "USDA: 17A2.V1", "violinID:1992" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001722
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.01)" ;
    rdfs:seeAlso "USDA: 1871.01", "violinID:2087" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001723
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.02)" ;
    rdfs:seeAlso "USDA: 1871.02", "violinID:2088" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001724
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.03)" ;
    rdfs:seeAlso "USDA: 1871.03", "violinID:2089" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001725
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.04)" ;
    rdfs:seeAlso "USDA: 1871.04", "violinID:2090" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001726
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.05)" ;
    rdfs:seeAlso "USDA: 1871.05", "violinID:2091" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001727
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Salmonella Typhimurium Live Culture Vaccine (USDA: 19C1.00)" ;
    rdfs:seeAlso "USDA: 19C1.00", "violinID:2124" ;
    rdfs:subClassOf obo:VO_0002507, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001728
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Salmonella Typhimurium Live Culture Vaccine (USDA: 19C1.01)" ;
    rdfs:seeAlso "USDA: 19C1.01", "violinID:2125" ;
    rdfs:subClassOf obo:VO_0002507, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001729
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Salmonella Typhimurium Live Culture Vaccine (USDA: 19C1.02)" ;
    rdfs:seeAlso "USDA: 19C1.02", "violinID:2126" ;
    rdfs:subClassOf obo:VO_0002507, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0001730
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Tenosynovitis Live Virus Vaccine (USDA: 1951.10)" ;
    rdfs:seeAlso "USDA: 1951.10", "violinID:2139" ;
    rdfs:subClassOf obo:VO_0001019, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001731
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.01)" ;
    rdfs:seeAlso "USDA: 1951.01", "violinID:2135" ;
    rdfs:subClassOf obo:VO_0001019, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001732
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.02)" ;
    rdfs:seeAlso "USDA: 1951.02", "violinID:2136" ;
    rdfs:subClassOf obo:VO_0001019, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001733
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.03)" ;
    rdfs:seeAlso "USDA: 1951.03", "violinID:2137" ;
    rdfs:subClassOf obo:VO_0001019, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001734
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.04)" ;
    rdfs:seeAlso "USDA: 1951.04", "violinID:2138" ;
    rdfs:subClassOf obo:VO_0001019, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001735
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.11)" ;
    rdfs:seeAlso "USDA: 1951.11", "violinID:2140" ;
    rdfs:subClassOf obo:VO_0001019, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001736
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Tenosynovitis Modified Live Virus Vaccine (USDA: 1952.01)" ;
    rdfs:seeAlso "USDA: 1952.01", "violinID:2141" ;
    rdfs:subClassOf obo:VO_0001019, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001737
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Duck Virus Enteritis Modified Live Virus Vaccine (USDA: 1461.10)" ;
    rdfs:seeAlso "USDA: 1461.10", "violinID:1712" ;
    rdfs:subClassOf obo:VO_0001525, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_104388
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001458 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001738
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Duck Virus Hepatitis Modified Live Virus Vaccine (USDA: 14B1.10)" ;
    rdfs:seeAlso "USDA: 14B1.10", "violinID:1713" ;
    rdfs:subClassOf obo:VO_0001528, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_691956
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001458 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001739
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Riemerella Anatipestifer Avirulent Live Culture Vaccine (USDA: 1811.00)" ;
    rdfs:seeAlso "USDA: 1811.00", "violinID:2120" ;
    rdfs:subClassOf obo:VO_0001512, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_8835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_34085
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001458 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001740
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Flavobacterium Columnare Avirulent Live Culture Vaccine (USDA: 17F1.00)" ;
    rdfs:seeAlso "USDA: 17F1.00", "violinID:1902" ;
    rdfs:subClassOf obo:VO_0000637, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_117565
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001741
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bordetella Bronchiseptica  Avirulent Live Culture Vaccine (USDA: 1081.00)" ;
    rdfs:seeAlso "USDA: 1081.00", "violinID:1172" ;
    rdfs:subClassOf obo:VO_0000394, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000060 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000061 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0001742
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bordetella Bronchiseptica  Avirulent Live Culture Vaccine (USDA: 1081.01)" ;
    rdfs:seeAlso "USDA: 1081.01", "violinID:1173" ;
    rdfs:subClassOf obo:VO_0000394, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0001743
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine (USDA: 14P5.20)" ;
    rdfs:seeAlso "USDA: 14P5.20", "violinID:1562" ;
    rdfs:subClassOf obo:VO_0000932, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001529 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ] .

obo:VO_0001744
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine (USDA: 14P5.21)" ;
    rdfs:seeAlso "USDA: 14P5.21", "violinID:1563" ;
    rdfs:subClassOf obo:VO_0000932, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001745
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Modified Live Virus Vaccine (USDA: 14P1.20)" ;
    rdfs:seeAlso "USDA: 14P1.20", "violinID:1561" ;
    rdfs:subClassOf obo:VO_0000932, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001746
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Influenza H3N8, Killed Virus Vaccine (USDA: 15K5.20)" ;
    rdfs:seeAlso "USDA: 15K5.20", "violinID:1691" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001747
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Parainfluenza Modified Live Virus Vaccine (USDA: 1421.21)" ;
    rdfs:seeAlso "USDA: 1421.21", "violinID:1692" ;
    rdfs:subClassOf obo:VO_0001526, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001748
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Distemper Live Canarypox Vector Vaccine (USDA: 1471.R0)" ;
    rdfs:seeAlso "USDA: 1471.R0", "violinID:1711" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001749
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Distemper Modified Live Virus Vaccine (USDA: 1471.10)" ;
    rdfs:seeAlso "USDA: 1471.10", "violinID:1710" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001750
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Giardia Lamblia Killed Protozoa Vaccine (USDA: 18G5.00)" ;
    rdfs:seeAlso "USDA: 18G5.00", "violinID:1926" ;
    rdfs:subClassOf obo:VO_0001083, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5741
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001751
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Neospora Caninum Killed Protozoa Vaccine (USDA: 1N11.00)" ;
    rdfs:seeAlso "USDA: 1N11.00", "violinID:1975" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001752
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine (USDA: 18P5.20)" ;
    rdfs:seeAlso "USDA: 18P5.20", "violinID:2085" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001753
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine (USDA: 18P5.21)" ;
    rdfs:seeAlso "USDA: 18P5.21", "violinID:2086" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001754
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Modified Live Virus Vaccine (USDA: 18M1.20)" ;
    rdfs:seeAlso "USDA: 18M1.20", "violinID:2079" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000062 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001529 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0001755
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Modified Live Virus Vaccine (USDA: 18M1.21)" ;
    rdfs:seeAlso "USDA: 18M1.21", "violinID:2080" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001756
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Modified Live Virus Vaccine (USDA: 18M1.22)" ;
    rdfs:seeAlso "USDA: 18M1.22", "violinID:2081" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001757
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Modified Live Virus Vaccine (USDA: 18M1.23)" ;
    rdfs:seeAlso "USDA: 18M1.23", "violinID:2082" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001758
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Modified Live Virus Vaccine (USDA: 18M1.25)" ;
    rdfs:seeAlso "USDA: 18M1.25", "violinID:2083" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001759
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Modified Live Virus Vaccine (USDA: 18M1.29)" ;
    rdfs:seeAlso "USDA: 18M1.29", "violinID:2084" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001760
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Killed Virus Vaccine (USDA: 1905.20)" ;
    rdfs:seeAlso "USDA: 1905.20", "violinID:2115" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0001761
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Killed Virus Vaccine (USDA: 1905.21)" ;
    rdfs:seeAlso "USDA: 1905.21", "violinID:2116" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0001762
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Killed Virus Vaccine (USDA: 1905.22)" ;
    rdfs:seeAlso "USDA: 1905.22", "violinID:2117" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001763
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Killed Virus Vaccine (USDA: 1905.23)" ;
    rdfs:seeAlso "USDA: 1905.23", "violinID:2118" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0001764
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Killed Virus Vaccine (USDA: 1905.24)" ;
    rdfs:seeAlso "USDA: 1905.24", "violinID:2119" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0001765
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Live Canarypox Vector Vaccine (USDA: 1901.R1)" ;
    rdfs:seeAlso "USDA: 1901.R1", "violinID:2113" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001766
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Live Canarypox Vector Vaccine (USDA: 1901.R6)" ;
    rdfs:seeAlso "USDA: 1901.R6", "violinID:2114" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001767
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Live Vaccinia Vector Vaccine (USDA: 1901.R0)" ;
    rdfs:seeAlso "USDA: 1901.R0", "violinID:2112" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001768
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Arteritis Modified Live Virus Vaccine (USDA: 1531.20)" ;
    rdfs:seeAlso "USDA: 1531.20", "violinID:1731" ;
    rdfs:subClassOf obo:VO_0001500, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001769
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Killed Virus Vaccine (USDA: 1505.10)" ;
    rdfs:seeAlso "USDA: 1505.10", "violinID:1735" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000264 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001770
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Killed Virus Vaccine (USDA: 1505.20)" ;
    rdfs:seeAlso "USDA: 1505.20", "violinID:1736" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001771
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Killed Virus Vaccine (USDA: 1505.21)" ;
    rdfs:seeAlso "USDA: 1505.21", "violinID:1737" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001772
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Killed Virus Vaccine (USDA: 1505.24)" ;
    rdfs:seeAlso "USDA: 1505.24", "violinID:1738" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001773
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Killed Virus Vaccine (USDA: 1505.25)" ;
    rdfs:seeAlso "USDA: 1505.25", "violinID:1739" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001774
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Killed Virus Vaccine (USDA: 1505.28)" ;
    rdfs:seeAlso "USDA: 1505.28", "violinID:1740" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001775
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Live Canarypox Vector Vaccine (USDA: 1501.R0)" ;
    rdfs:seeAlso "USDA: 1501.R0", "violinID:1734" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:VO_0000812
                obo:VO_0000864
            )
        ]
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001776
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Modified Live Virus Vaccine (USDA: 1501.10)" ;
    rdfs:seeAlso "USDA: 1501.10", "violinID:1732" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001777
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Influenza Modified Live Virus Vaccine (USDA: 1501.20)" ;
    rdfs:seeAlso "USDA: 1501.20", "violinID:1733" ;
    rdfs:subClassOf obo:VO_0000460, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001778
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.20)" ;
    rdfs:seeAlso "USDA: 1525.20", "violinID:1742" ;
    rdfs:subClassOf obo:VO_0001486, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001779
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.21)" ;
    rdfs:seeAlso "USDA: 1525.21", "violinID:1743" ;
    rdfs:subClassOf obo:VO_0001486, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ] .

obo:VO_0001780
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.22)" ;
    rdfs:seeAlso "USDA: 1525.22", "violinID:1744" ;
    rdfs:subClassOf obo:VO_0001486, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001781
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.24)" ;
    rdfs:seeAlso "USDA: 1525.24", "violinID:1745" ;
    rdfs:subClassOf obo:VO_0001486, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001782
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis Modified Live Virus Vaccine (USDA: 1521.20)" ;
    rdfs:seeAlso "USDA: 1521.20", "violinID:1741" ;
    rdfs:subClassOf obo:VO_0001486, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001783
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rotavirus Killed Virus Vaccine (USDA: 1E15.20)" ;
    rdfs:seeAlso "USDA: 1E15.20", "violinID:1756" ;
    rdfs:subClassOf obo:VO_0001496, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001784
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Streptococcus Equi Live Culture Vaccine (USDA: 1831.00)" ;
    rdfs:seeAlso "USDA: 1831.00", "violinID:2127" ;
    rdfs:subClassOf obo:VO_0000948, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001785
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Polyomavirus Killed Virus Vaccine (USDA: 1A15.00)" ;
    rdfs:seeAlso "USDA: 1A15.00", "violinID:1165" ;
    rdfs:subClassOf obo:VO_0001492, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9224
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001786
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Chlamydia Psittaci Killed Chlamydia Vaccine (USDA: 1585.20)" ;
    rdfs:seeAlso "USDA: 1585.20", "violinID:1701" ;
    rdfs:subClassOf obo:VO_0012174, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9224
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001787
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Chlamydia Psittaci Modified Live Chlamydia Vaccine (USDA: 1581.20)" ;
    rdfs:seeAlso "USDA: 1581.20", "violinID:1700" ;
    rdfs:subClassOf obo:VO_0012174, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9224
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001788
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pacheco's Disease Killed Virus Vaccine (USDA: 18C5.00)" ;
    rdfs:seeAlso "USDA: 18C5.00", "violinID:2076" ;
    rdfs:subClassOf obo:VO_0001518, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9224
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001789
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Erysipelothrix Rhusiopathiae Avirulent Live Culture Vaccine (USDA: 1541.00)" ;
    rdfs:seeAlso "USDA: 1541.00", "violinID:1757" ;
    rdfs:subClassOf obo:VO_0001456, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ] .

obo:VO_0001790
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Erysipelothrix Rhusiopathiae Avirulent Live Culture Vaccine (USDA: 1541.01)" ;
    rdfs:seeAlso "USDA: 1541.01", "violinID:1758" ;
    rdfs:subClassOf obo:VO_0001456, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ] .

obo:VO_0001791
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Erysipelothrix Rhusiopathiae Avirulent Live Culture Vaccine (USDA: 1541.02)" ;
    rdfs:seeAlso "USDA: 1541.02", "violinID:1759" ;
    rdfs:subClassOf obo:VO_0001456, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000265 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001792
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Erysipelothrix Rhusiopathiae Avirulent Live Culture Vaccine (USDA: 1541.03)" ;
    rdfs:seeAlso "USDA: 1541.03", "violinID:1760" ;
    rdfs:subClassOf obo:VO_0001456, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000265 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001793
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Erysipelothrix Rhusiopathiae Avirulent Live Culture Vaccine (USDA: 1541.04)" ;
    rdfs:seeAlso "USDA: 1541.04", "violinID:1761" ;
    rdfs:subClassOf obo:VO_0001456, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000265 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001794
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Haemophilus Parasuis Avirulent Live Culture Vaccine (USDA: 19J1.00)" ;
    rdfs:seeAlso "USDA: 19J1.00", "violinID:1927" ;
    rdfs:subClassOf obo:VO_0000611, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000268 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001795
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Lawsonia Intracellularis Avirulent Live Culture Vaccine (USDA: 10L1.00)" ;
    rdfs:seeAlso "USDA: 10L1.00", "violinID:1929" ;
    rdfs:subClassOf obo:VO_0001105, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29546
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001796
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Lawsonia Intracellularis Avirulent Live Culture Vaccine (USDA: 10L1.01)" ;
    rdfs:seeAlso "USDA: 10L1.01", "violinID:1930" ;
    rdfs:subClassOf obo:VO_0001105, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29546
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001797
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Lawsonia Intracellularis Avirulent Live Culture Vaccine (USDA: 10L1.02)" ;
    rdfs:seeAlso "USDA: 10L1.02", "violinID:1931" ;
    rdfs:subClassOf obo:VO_0001105, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29546
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001798
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Circovirus Type 2, Killed Virus Vaccine (USDA: 19K5.20)" ;
    rdfs:seeAlso "USDA: 19K5.20", "violinID:2095" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001799
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Reproductive & Respiratory Form, Modified Live Virus Vaccine (USDA: 19T1.20)" ;
    rdfs:seeAlso "USDA: 19T1.20", "violinID:2102" ;
    rdfs:subClassOf obo:VO_0001511, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001800
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Reproductive & Respiratory Form, Modified Live Virus Vaccine (USDA: 19T1.21)" ;
    rdfs:seeAlso "USDA: 19T1.21", "violinID:2103" ;
    rdfs:subClassOf obo:VO_0001511, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001801
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Reproductive Form, Killed Virus Vaccine (USDA: 19S5.20)" ;
    rdfs:seeAlso "USDA: 19S5.20", "violinID:2101" ;
    rdfs:subClassOf obo:VO_0001511, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001802
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Reproductive Form, Modified Live Virus Vaccine (USDA: 19Q1.20)" ;
    rdfs:seeAlso "USDA: 19Q1.20", "violinID:2098" ;
    rdfs:subClassOf obo:VO_0001511, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001803
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine (USDA: 19S1.20)" ;
    rdfs:seeAlso "USDA: 19S1.20", "violinID:2099" ;
    rdfs:subClassOf obo:VO_0001511, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001804
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine (USDA: 19S1.21)" ;
    rdfs:seeAlso "USDA: 19S1.21", "violinID:2100" ;
    rdfs:subClassOf obo:VO_0001511, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001805
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus Modified Live Virus Vaccine (USDA: 19E1.20)" ;
    rdfs:seeAlso "USDA: 19E1.20", "violinID:2104" ;
    rdfs:subClassOf obo:VO_0001495, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001806
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pseudorabies Modified Live Virus Vaccine (USDA: 1891.20)" ;
    rdfs:seeAlso "USDA: 1891.20", "violinID:2107" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ] .

obo:VO_0001807
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pseudorabies Modified Live Virus Vaccine (USDA: 1891.22)" ;
    rdfs:seeAlso "USDA: 1891.22", "violinID:2108" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001808
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pseudorabies Modified Live Virus Vaccine (USDA: 1891.R2)" ;
    rdfs:seeAlso "USDA: 1891.R2", "violinID:2109" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001809
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Pseudorabies Modified Live Virus Vaccine (USDA: 1891.R4)" ;
    rdfs:seeAlso "USDA: 1891.R4", "violinID:2110" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001810
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza pH1N1, Killed Virus Vaccine (USDA: 19A5.2P)" ;
    rdfs:seeAlso "USDA: 19A5.2P", "violinID:2134" ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001811
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Transmissible Gastroenteritis Modified Live Virus Vaccine (USDA: 1961.20)" ;
    rdfs:seeAlso "USDA: 1961.20", "violinID:2142" ;
    rdfs:subClassOf obo:VO_0001505, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11149
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001812
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "West Nile Virus Killed Virus Vaccine (USDA: 1995.20)" ;
    rdfs:seeAlso "USDA: 1995.20", "violinID:2147" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9768
    ] .

obo:VO_0001813
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "West Nile Virus Killed Virus Vaccine (USDA: 1995.22)" ;
    rdfs:seeAlso "USDA: 1995.22", "violinID:2148" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9768
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001814
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "West Nile Virus Live Canarypox Vector Vaccine (USDA: 1991.R0)" ;
    rdfs:seeAlso "USDA: 1991.R0", "violinID:2145" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9768
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001815
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "West Nile Virus Live Flavivirus Chimera Vaccine (USDA: 1991.R1)" ;
    rdfs:seeAlso "USDA: 1991.R1", "violinID:2146" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9768
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001816
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bluetongue Modified Live Virus Vaccine (USDA: 1061.00)" ;
    rdfs:seeAlso "USDA: 1061.00", "violinID:1170" ;
    rdfs:subClassOf obo:VO_0001515, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9940
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001817
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "WEB: https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM518295.pdf", "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5554" ;
    obo:VO_0001818 5554 ;
    a owl:Class ;
    rdfs:comment "Trade Name: Afluria Quadrivalent" ;
    rdfs:label "Afluria Quadrivalent"@en ;
    rdfs:seeAlso "CVX: 150" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000270 ;
        owl:someValuesFrom obo:VO_0000218
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000917
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000689 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:VO_0000908
    ] .

obo:VO_0001818
    obo:IAO_0000117 "Oliver He, Omar Tibi" ;
    a owl:AnnotationProperty ;
    rdfs:comment "An annotation property that represents a matched vaccine identifier used in the VIOLIN database." ;
    rdfs:label "VIOLIN vaccine ID", "VIOLIN vaccine ID"@en .

obo:VO_0001819
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Arthrobacter  Live Culture  Vaccine (USDA: 1K11.00)" ;
    rdfs:seeAlso "USDA: 1K11.00", "violinID:1123" ;
    rdfs:subClassOf obo:VO_0001151, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_504568
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001820
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bordetella Avium Avirulent Live Culture Vaccine (USDA: 1021.01)" ;
    rdfs:seeAlso "USDA: 1021.01", "violinID:1171" ;
    rdfs:subClassOf obo:VO_0001114, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9103
    ] .

obo:VO_0001821
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Escherichia coli avirulent live culture vaccine (USDA: 1551.02)" ;
    rdfs:seeAlso "USDA: 1551.02", "violinID:1762" ;
    rdfs:subClassOf obo:VO_0000962, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9103
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_562
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000265 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001822
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Escherichia coli avirulent live culture vaccine (USDA: 15R1.00)" ;
    rdfs:seeAlso "USDA: 15R1.00", "violinID:1764" ;
    rdfs:subClassOf obo:VO_0000619, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9103
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000265 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001823
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Escherichia coli live culture vaccine (USDA: 1551.R0)" ;
    rdfs:seeAlso "USDA: 1551.R0", "violinID:1763" ;
    rdfs:subClassOf obo:VO_0000619, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9103
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001824
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Hemorrhagic Enteritis Live Virus Vaccine (USDA: 17E1.20)" ;
    rdfs:seeAlso "USDA: 17E1.20", "violinID:1928" ;
    rdfs:subClassOf obo:VO_0001516, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000265 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000296 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9103
    ] .

obo:VO_0001825
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Circovirus Type 2, Killed Baculovirus Vector Vaccine (USDA: 19K5.R0)" ;
    rdfs:seeAlso "USDA: 19K5.R0", "violinID:2096" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001826
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.12)" ;
    rdfs:seeAlso "USDA: 19A5.12", "violinID:2128" ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001827
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.22)" ;
    rdfs:seeAlso "USDA: 19A5.22", "violinID:2129" ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0001828
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.23)" ;
    rdfs:seeAlso "USDA: 19A5.23", "violinID:2130" ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001829
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.24)" ;
    rdfs:seeAlso "USDA: 19A5.24", "violinID:2131" ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0001830
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.26)" ;
    rdfs:seeAlso "USDA: 19A5.26", "violinID:2132" ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001831
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.29)" ;
    rdfs:seeAlso "USDA: 19A5.29", "violinID:2133" ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001832
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine (USDA: 1679.31)" ;
    rdfs:seeAlso "USDA: 1679.31", "violinID:1970;1971" ;
    rdfs:subClassOf obo:VO_0002484, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001833
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine-Clostridium Botulinum Type C Bacterin-Toxoid (USDA: 4929.31)" ;
    rdfs:seeAlso "USDA: 4929.31", "violinID:2884;2885;2886" ;
    rdfs:subClassOf obo:VO_0002449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001834
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine-Clostridium botulinum Type C-Pseudomonas aeruginosa Bacterin-Toxoid (USDA: 4949.20)" ;
    rdfs:seeAlso "USDA: 4949.20", "violinID:2887;28882889;2890" ;
    rdfs:subClassOf obo:VO_0002450, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001835
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine-Clostridium botulinum Type C-Pseudomonas aeruginosa Bacterin-Toxoid (USDA: 4949.31)" ;
    rdfs:seeAlso "USDA: 4949.31", "violinID:2891;2892;2893;2894" ;
    rdfs:subClassOf obo:VO_0002450, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001836
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Modified Live Virus & Killed Virus Vaccine-Clostridium botulinum Type C Bacterin-Toxoid (USDA: 4929.20)" ;
    rdfs:seeAlso "USDA: 4929.20", "violinID:2881;2882;2883" ;
    rdfs:subClassOf obo:VO_0002449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001837
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Enteritis Killed Virus Vaccine-Clostridium botulinum Type C Bacterin-Toxoid (USDA: 4955.20)" ;
    rdfs:seeAlso "USDA: 4955.20", "violinID:2895;2896" ;
    rdfs:subClassOf obo:VO_0002449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001838
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Enteritis Killed Virus Vaccine-Clostridium botulinum Type C Bacterin-Toxoid (USDA: 4955.21)" ;
    rdfs:seeAlso "USDA: 4955.21", "violinID:2897;2898" ;
    rdfs:subClassOf obo:VO_0002451, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001839
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Enteritis Killed Virus Vaccine-Clostridium botulinum Type C-Pseudomonas aeruginosa Bacterin-Toxoid (USDA: 49A5.20)" ;
    rdfs:seeAlso "USDA: 49A5.20", "violinID:2899;2900;2901" ;
    rdfs:subClassOf obo:VO_0002452, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001840
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Enteritis Killed Virus Vaccine-Clostridium botulinum Type C-Pseudomonas aeruginosa Bacterin-Toxoid (USDA: 49A5.21)" ;
    rdfs:seeAlso "USDA: 49A5.21", "violinID:2902;2903;2904" ;
    rdfs:subClassOf obo:VO_0002452, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000056 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001841
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Immunodeficiency-Leukemia Virus Killed Virus Vaccine (USDA: 15D5.R0)" ;
    rdfs:seeAlso "USDA: 15D5.R0", "violinID:1769;1770" ;
    rdfs:subClassOf obo:VO_0002427, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001842
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 1A69.20)" ;
    rdfs:seeAlso "USDA: 1A69.20", "violinID:1777;1778" ;
    rdfs:subClassOf obo:VO_0002432, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001843
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 15B5.20)" ;
    rdfs:seeAlso "USDA: 15B5.20", "violinID:1779;1780;1781;1782" ;
    rdfs:subClassOf obo:VO_0002433, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001844
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 15B5.21)" ;
    rdfs:seeAlso "USDA: 15B5.21", "violinID:1783;1784;1785;1786" ;
    rdfs:subClassOf obo:VO_0002433, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001845
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Modified Live & Killed Virus Vaccine (USDA: 15B9.20)" ;
    rdfs:seeAlso "USDA: 15B9.20", "violinID:1787;1788;1789;1790" ;
    rdfs:subClassOf obo:VO_0002433, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001846
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Modified Live & Killed Virus Vaccine (USDA: 15B9.21)" ;
    rdfs:seeAlso "USDA: 15B9.21", "violinID:1791;1792;1793;1794" ;
    rdfs:subClassOf obo:VO_0002433, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001847
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 1559.20)" ;
    rdfs:seeAlso "USDA: 1559.20", "violinID:1795;1796;1797;1798;1799" ;
    rdfs:subClassOf obo:VO_0002434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001848
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 1559.23)" ;
    rdfs:seeAlso "USDA: 1559.23", "violinID:1800;1801;1802;1803;1804" ;
    rdfs:subClassOf obo:VO_0002434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001849
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live & Killed Virus, Killed Chlamydia Vaccine (USDA: 1559.2C)" ;
    rdfs:seeAlso "USDA: 1559.2C", "violinID:1810;1811;1812;1813;1814" ;
    rdfs:subClassOf obo:VO_0002434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001850
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live & Killed Virus, Modified Live Chlamydia Vaccine (USDA: 1559.2B)" ;
    rdfs:seeAlso "USDA: 1559.2B", "violinID:1805;1806;1807;1808;1809" ;
    rdfs:subClassOf obo:VO_0002434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001851
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16F1.20)" ;
    rdfs:seeAlso "USDA: 16F1.20", "violinID:1821;1822;1823" ;
    rdfs:subClassOf obo:VO_0002435, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001852
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16F1.21)" ;
    rdfs:seeAlso "USDA: 16F1.21", "violinID:1824;1825;1826" ;
    rdfs:subClassOf obo:VO_0002435, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001853
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 16D5.20)" ;
    rdfs:seeAlso "USDA: 16D5.20", "violinID:1839;1840;1841" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001854
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 16D5.23)" ;
    rdfs:seeAlso "USDA: 16D5.23", "violinID:1842;1843;1844" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001855
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Modified Live & Killed Virus Vaccine (USDA: 16D9.20)" ;
    rdfs:seeAlso "USDA: 16D9.20", "violinID:1851;1852;1853" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001856
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.20)" ;
    rdfs:seeAlso "USDA: 16D1.20", "violinID:1827;1828;1829" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001857
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.22)" ;
    rdfs:seeAlso "USDA: 16D1.22", "violinID:1830;1831;1832" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001858
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.23)" ;
    rdfs:seeAlso "USDA: 16D1.23", "violinID:1833;1834;1835" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001859
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.24)" ;
    rdfs:seeAlso "USDA: 16D1.24", "violinID:1836;1837;1838" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001860
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D8.20)" ;
    rdfs:seeAlso "USDA: 16D8.20", "violinID:1845;1846;1847" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001861
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D8.21)" ;
    rdfs:seeAlso "USDA: 16D8.21", "violinID:1848;1849;1850" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001862
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 16E5.20)" ;
    rdfs:seeAlso "USDA: 16E5.20", "violinID:1862;1863;18641865" ;
    rdfs:subClassOf obo:VO_0002437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001863
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 16E5.23)" ;
    rdfs:seeAlso "USDA: 16E5.23", "violinID:1866;1867;1868;1869" ;
    rdfs:subClassOf obo:VO_0002437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001864
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Killed Chlamydia Vaccine (USDA: 16E6.20)" ;
    rdfs:seeAlso "USDA: 16E6.20", "violinID:1870;1871;1872;1873" ;
    rdfs:subClassOf obo:VO_0002437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001865
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16E1.20)" ;
    rdfs:seeAlso "USDA: 16E1.20", "violinID:1854;1855;1856;1857" ;
    rdfs:subClassOf obo:VO_0002437, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001866
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16E1.24)" ;
    rdfs:seeAlso "USDA: 16E1.24", "violinID:1858;1859;1860;1861" ;
    rdfs:subClassOf obo:VO_0002437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001867
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16E8.20)" ;
    rdfs:seeAlso "USDA: 16E8.20", "violinID:1874;1875;1876;1877" ;
    rdfs:subClassOf obo:VO_0002437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001868
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci-Rabies Modified Live & Killed Virus, Modified Live Chlamydia Vaccine (USDA: 1619.20)" ;
    rdfs:seeAlso "USDA: 1619.20", "violinID:1878;1879;1880;1881" ;
    rdfs:subClassOf obo:VO_0002438, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001869
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci-Rabies Modified Live Virus and Chlamydia, Canarypox Vector Vaccine (USDA: 1619.R1)" ;
    rdfs:seeAlso "USDA: 1619.R1", "violinID:1883;18841885;1886;1887" ;
    rdfs:subClassOf obo:VO_0002438, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001870
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Rabies Modified Live & Killed Virus Vaccine (USDA: 16T9.20)" ;
    rdfs:seeAlso "USDA: 16T9.20", "violinID:1888;1889;1890;1891" ;
    rdfs:subClassOf obo:VO_0002439, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001871
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Rabies Modified Live Virus, Canarypox Vector Vaccine (USDA: 16T9.R0)" ;
    rdfs:seeAlso "USDA: 16T9.R0", "violinID:1892;1893;1894;1895" ;
    rdfs:subClassOf obo:VO_0002439, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001872
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calicivirus Modified Live Virus Vaccine (USDA: 16C1.20)" ;
    rdfs:seeAlso "USDA: 16C1.20", "violinID:1896;1897" ;
    rdfs:subClassOf obo:VO_0002440, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001873
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calicivirus Modified Live Virus Vaccine (USDA: 16C1.21)" ;
    rdfs:seeAlso "USDA: 16C1.21", "violinID:1898;1899" ;
    rdfs:subClassOf obo:VO_0002440, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001874
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calicivirus Modified Live Virus Vaccine (USDA: 16C1.22)" ;
    rdfs:seeAlso "USDA: 16C1.22", "violinID:1899;1900" ;
    rdfs:subClassOf obo:VO_0002440, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001875
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.00)" ;
    rdfs:seeAlso "USDA: 1161.00", "violinID:1174;1175" ;
    rdfs:subClassOf obo:VO_0002330, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001876
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.20)" ;
    rdfs:seeAlso "USDA: 1161.20", "violinID:1176;1177" ;
    rdfs:subClassOf obo:VO_0002330, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001877
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.20)" ;
    rdfs:seeAlso "USDA: 45H5.20", "violinID:2152;2153;2154;2155" ;
    rdfs:subClassOf obo:VO_0002331, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000058 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001878
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.21)" ;
    rdfs:seeAlso "USDA: 45H5.21", "violinID:2156;2157;2158;2159" ;
    rdfs:subClassOf obo:VO_0002331, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000058 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001879
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 4109.20)" ;
    rdfs:seeAlso "USDA: 4109.20", "violinID:2160;2161;2162;2163;2164" ;
    rdfs:subClassOf obo:VO_0002332, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000058 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001880
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4019.00)" ;
    rdfs:seeAlso "USDA: 4019.00", "violinID:2165;2166" ;
    rdfs:subClassOf obo:VO_0002333, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001881
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4059.00)" ;
    rdfs:seeAlso "USDA: 4059.00", "violinID:2167;2168" ;
    rdfs:subClassOf obo:VO_0002334, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001882
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4069.20)" ;
    rdfs:seeAlso "USDA: 4069.20", "violinID:2169;2170" ;
    rdfs:subClassOf obo:VO_0002335, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001883
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.00)" ;
    rdfs:seeAlso "USDA: 4089.00", "violinID:2171;2172" ;
    rdfs:subClassOf obo:VO_0002336, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001884
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.20)" ;
    rdfs:seeAlso "USDA: 4089.20", "violinID:2173;2174" ;
    rdfs:subClassOf obo:VO_0002336, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001885
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Killed Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin (USDA: 4265.00)" ;
    rdfs:seeAlso "USDA: 4265.00", "violinID:2187;2188;2189;2190" ;
    rdfs:subClassOf obo:VO_0002337, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001886
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.00)" ;
    rdfs:seeAlso "USDA: 1121.00", "violinID:1187;1188" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001887
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.20)" ;
    rdfs:seeAlso "USDA: 1121.20", "violinID:1189;1190" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001888
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.21)" ;
    rdfs:seeAlso "USDA: 1121.21", "violinID:1191;1192" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001889
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.24)" ;
    rdfs:seeAlso "USDA: 1121.24", "violinID:1193;1194" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001890
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1121.31)" ;
    rdfs:seeAlso "USDA: 1121.31", "violinID:1195;1196" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001891
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus somnus Bacterin (USDA: 4139.20)" ;
    rdfs:seeAlso "USDA: 4139.20", "violinID:2175;2176;2177" ;
    rdfs:subClassOf obo:VO_0002339, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001892
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4129.00)" ;
    rdfs:seeAlso "USDA: 4129.00", "violinID:2178;2179;2180" ;
    rdfs:subClassOf obo:VO_0002340, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001893
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4179.00)" ;
    rdfs:seeAlso "USDA: 4179.00", "violinID:2181;2182;2183" ;
    rdfs:subClassOf obo:VO_0002341, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001894
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4209.00)" ;
    rdfs:seeAlso "USDA: 4209.00", "violinID:2184;2185;2186" ;
    rdfs:subClassOf obo:VO_0002342, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001895
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.00)" ;
    rdfs:seeAlso "USDA: 1071.00", "violinID:1197;1198;1199" ;
    rdfs:subClassOf obo:VO_0002343, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001896
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.20)" ;
    rdfs:seeAlso "USDA: 1071.20", "violinID:1200;1201;1202" ;
    rdfs:subClassOf obo:VO_0002343, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000058 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001897
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.21)" ;
    rdfs:seeAlso "USDA: 1071.21", "violinID:1203;1204;1205" ;
    rdfs:subClassOf obo:VO_0002343, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001898
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.22)" ;
    rdfs:seeAlso "USDA: 1071.22", "violinID:1206;1207;1208" ;
    rdfs:subClassOf obo:VO_0002343, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001899
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.23)" ;
    rdfs:seeAlso "USDA: 1071.23", "violinID:1209;1210;1211" ;
    rdfs:subClassOf obo:VO_0002343, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001900
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11B5.20)" ;
    rdfs:seeAlso "USDA: 11B5.20", "violinID:1213;1214" ;
    rdfs:subClassOf obo:VO_0002344, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001901
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine (USDA: 1155.20)" ;
    rdfs:seeAlso "USDA: 1155.20", "violinID:1224;1225" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001902
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine (USDA: 1155.30)" ;
    rdfs:seeAlso "USDA: 1155.30", "violinID:1226;1227" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001903
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.20)" ;
    rdfs:seeAlso "USDA: 4145.20", "violinID:2195;2196;2197;2198" ;
    rdfs:subClassOf obo:VO_0002346, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001904
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.21)" ;
    rdfs:seeAlso "USDA: 4145.21", "violinID:2199;2200;2201;2202" ;
    rdfs:subClassOf obo:VO_0002346, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001905
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 43S5.20)" ;
    rdfs:seeAlso "USDA: 43S5.20", "violinID:2203;22042205;2206;2207" ;
    rdfs:subClassOf obo:VO_0002347, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000058 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001906
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 43T5.20)" ;
    rdfs:seeAlso "USDA: 43T5.20", "violinID:2208;2209;2210;2211;2212;2213" ;
    rdfs:subClassOf obo:VO_0002348, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000058 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001907
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4335.20)" ;
    rdfs:seeAlso "USDA: 4335.20", "violinID:2214;2215;2216" ;
    rdfs:subClassOf obo:VO_0002349, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001908
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4336.30)" ;
    rdfs:seeAlso "USDA: 4336.30", "violinID:2217;2218;2219" ;
    rdfs:subClassOf obo:VO_0002349, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001909
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.00)" ;
    rdfs:seeAlso "USDA: 1151.00", "violinID:1214;1215" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001910
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.20)" ;
    rdfs:seeAlso "USDA: 1151.20", "violinID:1216;1217" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001911
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.22)" ;
    rdfs:seeAlso "USDA: 1151.22", "violinID:1218;1219" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001912
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.23)" ;
    rdfs:seeAlso "USDA: 1151.23", "violinID:1220;1221" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001913
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine (USDA: 1151.26)" ;
    rdfs:seeAlso "USDA: 1151.26", "violinID:1222;1223" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001914
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4141.20)" ;
    rdfs:seeAlso "USDA: 4141.20", "violinID:2191;2192;2193;2194" ;
    rdfs:subClassOf obo:VO_0002346, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001915
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4339.00)" ;
    rdfs:seeAlso "USDA: 4339.00", "violinID:2220;2221;2222" ;
    rdfs:subClassOf obo:VO_0002349, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001916
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4359.00)" ;
    rdfs:seeAlso "USDA: 4359.00", "violinID:2223;2224;2225" ;
    rdfs:subClassOf obo:VO_0002350, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001917
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4399.20)" ;
    rdfs:seeAlso "USDA: 4399.20", "violinID:2226;2227;2228" ;
    rdfs:subClassOf obo:VO_0002351, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001918
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.00)" ;
    rdfs:seeAlso "USDA: 4389.00", "violinID:2229;2230;2231" ;
    rdfs:subClassOf obo:VO_0002352, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001919
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.20)" ;
    rdfs:seeAlso "USDA: 4389.20", "violinID:2232;2233;2234" ;
    rdfs:subClassOf obo:VO_0002352, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001920
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.21)" ;
    rdfs:seeAlso "USDA: 4389.21", "violinID:2235;2236;2237" ;
    rdfs:subClassOf obo:VO_0002352, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001921
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine (USDA: 1175.20)" ;
    rdfs:seeAlso "USDA: 1175.20", "violinID:1252;1253;1254" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001922
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4435.20)" ;
    rdfs:seeAlso "USDA: 4435.20", "violinID:2252;2253;2254;2255" ;
    rdfs:subClassOf obo:VO_0002349, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001923
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.00)" ;
    rdfs:seeAlso "USDA: 1171.00", "violinID:1228;1229;1230" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001924
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.20)" ;
    rdfs:seeAlso "USDA: 1171.20", "violinID:1231;1232;1233" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001925
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.22)" ;
    rdfs:seeAlso "USDA: 1171.22", "violinID:1234;1235;1236" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001926
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.24)" ;
    rdfs:seeAlso "USDA: 1171.24", "violinID:1237;1238;1239" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001927
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.25)" ;
    rdfs:seeAlso "USDA: 1171.25", "violinID:1240;1241;1242" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001928
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.26)" ;
    rdfs:seeAlso "USDA: 1171.26", "violinID:1243;1244;1245" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001929
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.27)" ;
    rdfs:seeAlso "USDA: 1171.27", "violinID:1246;1247;1248" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001930
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1171.30)" ;
    rdfs:seeAlso "USDA: 1171.30", "violinID:1249;1250;1251" ;
    rdfs:subClassOf obo:VO_0002353, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001931
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.24)" ;
    rdfs:seeAlso "USDA: 4560.24", "violinID:2238;2239;2240;2241" ;
    rdfs:subClassOf obo:VO_0002354, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001932
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.25)" ;
    rdfs:seeAlso "USDA: 4560.25", "violinID:2242;2243;2244;2245" ;
    rdfs:subClassOf obo:VO_0002354, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001933
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus somnus-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4489.30)" ;
    rdfs:seeAlso "USDA: 4489.30", "violinID:2246;2247;2248;2249;2250;2251" ;
    rdfs:subClassOf obo:VO_0002490, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001934
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.00)" ;
    rdfs:seeAlso "USDA: 4439.00", "violinID:2256;2257;2258;2259" ;
    rdfs:subClassOf obo:VO_0002355, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001935
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.20)" ;
    rdfs:seeAlso "USDA: 4439.20", "violinID:2260;2261;2262;2263" ;
    rdfs:subClassOf obo:VO_0002355, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001936
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4479.00)" ;
    rdfs:seeAlso "USDA: 4479.00", "violinID:2264;2265;2266;2267" ;
    rdfs:subClassOf obo:VO_0002356, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001937
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4509.00)" ;
    rdfs:seeAlso "USDA: 4509.00", "violinID:2268;2269;2270;2271" ;
    rdfs:subClassOf obo:VO_0002488, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001938
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Killed Virus Vaccine-Mannheimia Haemolytica Bacterin (USDA: 44A5.20)" ;
    rdfs:seeAlso "USDA: 44A5.20", "violinID:2486;2487;2488;2489" ;
    rdfs:subClassOf obo:VO_0002357, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001939
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.00)" ;
    rdfs:seeAlso "USDA: 1181.00", "violinID:1255;1256;1257;1258" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001940
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.20)" ;
    rdfs:seeAlso "USDA: 1181.20", "violinID:1259;1260;1261;1262" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001941
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.21)" ;
    rdfs:seeAlso "USDA: 1181.21", "violinID:1263;1263;1265;1266" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001942
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.22)" ;
    rdfs:seeAlso "USDA: 1181.22", "violinID:1267;1268;1269;1270" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001943
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.23)" ;
    rdfs:seeAlso "USDA: 1181.23", "violinID:1271;1272;1273;1274" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001944
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.24)" ;
    rdfs:seeAlso "USDA: 1181.24", "violinID:1275;1276;1277;1278" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001945
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.25)" ;
    rdfs:seeAlso "USDA: 1181.25", "violinID:1279;1280;1281;1282" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001946
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.26)" ;
    rdfs:seeAlso "USDA: 1181.26", "violinID:1283;1284;1285;1286" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001947
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.28)" ;
    rdfs:seeAlso "USDA: 1181.28", "violinID:1287;1288;1289;1290" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001948
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus  Modified Live Virus Vaccine (USDA: 1181.30)" ;
    rdfs:seeAlso "USDA: 1181.30", "violinID:1291;1292;1293;1294" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001949
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.20)" ;
    rdfs:seeAlso "USDA: 1185.20", "violinID:1295;1296;1297;1298" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001950
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.22)" ;
    rdfs:seeAlso "USDA: 1185.22", "violinID:1299;1300;1301;1302" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001951
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20)" ;
    rdfs:seeAlso "USDA: 44M5.20", "violinID:2277;2278;2279;2280;2281;2282" ;
    rdfs:subClassOf obo:VO_0002359, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001952
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22)" ;
    rdfs:seeAlso "USDA: 44M5.22", "violinID:2283;2284;2285;2286;2287;2288" ;
    rdfs:subClassOf obo:VO_0002359, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001953
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20)" ;
    rdfs:seeAlso "USDA: 44B5.20", "violinID:2313;2314;2315;2316;2317;2318" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001954
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20)" ;
    rdfs:seeAlso "USDA: 44B6.20", "violinID:2319;2320;2321;2322;2323;2324" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001955
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21)" ;
    rdfs:seeAlso "USDA: 44B6.21", "violinID:2325;2326;2327;2328;2329;2330" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001956
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44C5.20)" ;
    rdfs:seeAlso "USDA: 44C5.20", "violinID:2343;2344;2345;2346" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001957
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44C7.20)" ;
    rdfs:seeAlso "USDA: 44C7.20", "violinID:2347;2348;2349;2350" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001958
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44D5.20)" ;
    rdfs:seeAlso "USDA: 44D5.20", "violinID:2367;2368;2369;2370" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001959
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.20)" ;
    rdfs:seeAlso "USDA: 44D7.20", "violinID:2375;2376;2377;2378;2379" ;
    rdfs:subClassOf obo:VO_0002362, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001960
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.22)" ;
    rdfs:seeAlso "USDA: 44D7.22", "violinID:2380;2381;2382;2383;2384" ;
    rdfs:subClassOf obo:VO_0002362, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001961
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus somnus-Mannheimia Haemolytica Bacterin (USDA: 4477.20)" ;
    rdfs:seeAlso "USDA: 4477.20", "violinID:2405;2406;2407;2408;2409" ;
    rdfs:subClassOf obo:VO_0002363, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001962
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.20)" ;
    rdfs:seeAlso "USDA: 4465.20", "violinID:2426;2427;2428;2429" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001963
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.21)" ;
    rdfs:seeAlso "USDA: 4465.21", "violinID:2430;2431;2432;2433" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001964
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.22)" ;
    rdfs:seeAlso "USDA: 4465.22", "violinID:2434;2435;2436;2437" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001965
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.20)" ;
    rdfs:seeAlso "USDA: 4466.20", "violinID:2438;2439;2440;2441" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001966
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.21)" ;
    rdfs:seeAlso "USDA: 4466.21", "violinID:2442;2443;2444;2445" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001967
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona-Mannheimia Haemolytica Bacterin (USDA: 4475.20)" ;
    rdfs:seeAlso "USDA: 4475.20", "violinID:2482;2483;2484;2485" ;
    rdfs:subClassOf obo:VO_0002366, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001968
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.20)" ;
    rdfs:seeAlso "USDA: 1187.20", "violinID:1303;1304;1305;1306" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001969
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.21)" ;
    rdfs:seeAlso "USDA: 1187.21", "violinID:1307;1308;1309;1310" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001970
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.22)" ;
    rdfs:seeAlso "USDA: 1187.22", "violinID:1311;1312;1313;1314" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001971
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.25)" ;
    rdfs:seeAlso "USDA: 1187.25", "violinID:1315;1316;1317;1318" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001972
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.00)" ;
    rdfs:seeAlso "USDA: 1189.00", "violinID:1319;1320;1321;1322" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001973
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.21)" ;
    rdfs:seeAlso "USDA: 1189.21", "violinID:1323;1324;1325;1326" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001974
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.30)" ;
    rdfs:seeAlso "USDA: 1189.30", "violinID:1327;1328;1329;1330" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001975
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21)" ;
    rdfs:seeAlso "USDA: 44B9.21", "violinID:2331;2332;2333;2334;2335" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001976
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22)" ;
    rdfs:seeAlso "USDA: 44B9.22", "violinID:2337;2338;2339;2340;2341;2342" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001977
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44F9.20)" ;
    rdfs:seeAlso "USDA: 44F9.20", "violinID:2371;2372;2373;2374" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001978
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.20)" ;
    rdfs:seeAlso "USDA: 4469.20", "violinID:2454;2455;2456;2457" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001979
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.22)" ;
    rdfs:seeAlso "USDA: 4469.22", "violinID:2458;2459;2460;2461" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001980
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.25)" ;
    rdfs:seeAlso "USDA: 4469.25", "violinID:2470;2471;2472;2473" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001981
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.30)" ;
    rdfs:seeAlso "USDA: 4469.30", "violinID:2478;2479;2480;2481" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001982
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20)" ;
    rdfs:seeAlso "USDA: 44B1.20", "violinID:2289;2290;2291;2292;2293;2294" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001983
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22)" ;
    rdfs:seeAlso "USDA: 44B1.22", "violinID:2295;2296;2297;2298;2299;2300" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001984
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23)" ;
    rdfs:seeAlso "USDA: 44B1.23", "violinID:2301;2302;2303;2304;2305;2306" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001985
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25)" ;
    rdfs:seeAlso "USDA: 44B1.25", "violinID:2307;2308;2309;2310;2311;2312" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001986
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44C9.20)" ;
    rdfs:seeAlso "USDA: 44C9.20", "violinID:2351;2352;2353;2354" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001987
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44C9.21)" ;
    rdfs:seeAlso "USDA: 44C9.21", "violinID:2355;2356;2357;2358" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001988
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44C9.23)" ;
    rdfs:seeAlso "USDA: 44C9.23", "violinID:2359;2360;2361;2362" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001989
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus Bacterin (USDA: 44C9.24)" ;
    rdfs:seeAlso "USDA: 44C9.24", "violinID:2363;2364;2365;2366" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001990
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.20)" ;
    rdfs:seeAlso "USDA: 44D9.20", "violinID:2385;2386;2387;2388;2389" ;
    rdfs:subClassOf obo:VO_0002362, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001991
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.21)" ;
    rdfs:seeAlso "USDA: 44D9.21", "violinID:2390;2391;2392;2393;2394" ;
    rdfs:subClassOf obo:VO_0002362, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001992
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.23)" ;
    rdfs:seeAlso "USDA: 44D9.23", "violinID:2395;2396;2397;2398;2399" ;
    rdfs:subClassOf obo:VO_0002362, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001993
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.24)" ;
    rdfs:seeAlso "USDA: 44D9.24", "violinID:2400;2401;2402;2403;2404" ;
    rdfs:subClassOf obo:VO_0002362, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001994
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.20)" ;
    rdfs:seeAlso "USDA: 4461.20", "violinID:2410;2411;2412;2413" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000057 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001995
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.21)" ;
    rdfs:seeAlso "USDA: 4461.21", "violinID:2414;2415;2416;2417" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001996
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.22)" ;
    rdfs:seeAlso "USDA: 4461.22", "violinID:2418;2419;2420;2421" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0001997
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.25)" ;
    rdfs:seeAlso "USDA: 4461.25", "violinID:2422;2423;2424;2425" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001998
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.00)" ;
    rdfs:seeAlso "USDA: 4469.00", "violinID:2446;2447;2448;2449" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0001999
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.01)" ;
    rdfs:seeAlso "USDA: 4469.01", "violinID:2450;2451;2452;2453" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002000
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.23)" ;
    rdfs:seeAlso "USDA: 4469.23", "violinID:2462;2463;2464;2465" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002001
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.24)" ;
    rdfs:seeAlso "USDA: 4469.24", "violinID:2466;2467;2468;2469" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002002
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.26)" ;
    rdfs:seeAlso "USDA: 4469.26", "violinID:2474;2475;2476;2477" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002003
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20)" ;
    rdfs:seeAlso "USDA: 4L49.20", "violinID:2272;2273;2274;2275;2276" ;
    rdfs:subClassOf obo:VO_0002368, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002004
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.20)" ;
    rdfs:seeAlso "USDA: 4X49.20", "violinID:2490;2491;2492;2493" ;
    rdfs:subClassOf obo:VO_0002369, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002005
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.21)" ;
    rdfs:seeAlso "USDA: 4X49.21", "violinID:2494;2495;2496;2497" ;
    rdfs:subClassOf obo:VO_0002369, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002006
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.20)" ;
    rdfs:seeAlso "USDA: 45B9.20", "violinID:2498;2499;2500;2501;2502" ;
    rdfs:subClassOf obo:VO_0002370, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002007
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.21)" ;
    rdfs:seeAlso "USDA: 45B9.21", "violinID:2503;2504;2505;2506;2507" ;
    rdfs:subClassOf obo:VO_0002370, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002008
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Modified Live Virus, Avirulent Live Culture Vaccine (USDA: 11A8.22)" ;
    rdfs:seeAlso "USDA: 11A8.22", "violinID:1331;1332;1333;1334;1335;1336" ;
    rdfs:subClassOf obo:VO_0002371, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002009
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11A5.20)" ;
    rdfs:seeAlso "USDA: 11A5.20", "violinID:1346;1347;1348" ;
    rdfs:subClassOf obo:VO_0002372, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002010
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.20)" ;
    rdfs:seeAlso "USDA: 11A1.20", "violinID:1337;1338;139" ;
    rdfs:subClassOf obo:VO_0002372, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002011
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.26)" ;
    rdfs:seeAlso "USDA: 11A1.26", "violinID:1340;1341;1342" ;
    rdfs:subClassOf obo:VO_0002372, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002012
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.30)" ;
    rdfs:seeAlso "USDA: 11A1.30", "violinID:1343;1344;1345" ;
    rdfs:subClassOf obo:VO_0002372, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002013
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20)" ;
    rdfs:seeAlso "USDA: 4367.20", "violinID:2508;2509;2510;2511" ;
    rdfs:subClassOf obo:VO_0002373, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002014
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26)" ;
    rdfs:seeAlso "USDA: 4367.26", "violinID:2512;2513;2514;2515" ;
    rdfs:subClassOf obo:VO_0002373, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002015
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30)" ;
    rdfs:seeAlso "USDA: 4367.30", "violinID:2516;2517;2518;2519" ;
    rdfs:subClassOf obo:VO_0002373, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000057 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002016
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus  Modified Killed Virus Vaccine (USDA: 1935.20)" ;
    rdfs:seeAlso "USDA: 1935.20", "violinID:1350" ;
    rdfs:subClassOf obo:VO_0002374, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002017
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus  Modified Live Virus Vaccine (USDA: 1931.20)" ;
    rdfs:seeAlso "USDA: 1931.20", "violinID:1349" ;
    rdfs:subClassOf obo:VO_0002374, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002018
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid (USDA: 4570.20)" ;
    rdfs:seeAlso "USDA: 4570.20", "violinID:2520;2521;2522;2523" ;
    rdfs:subClassOf obo:VO_0002375, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002019
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid (USDA: 4570.22)" ;
    rdfs:seeAlso "USDA: 4570.22", "violinID:2524;2525;2526;2527" ;
    rdfs:subClassOf obo:VO_0002375, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002020
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Clostridium Perfringens Types C & D-Escherichia Coli Bacterin-Toxoid (USDA: 4575.20)" ;
    rdfs:seeAlso "USDA: 4575.20", "violinID:2528;2529;2530;2531" ;
    rdfs:subClassOf obo:VO_0002376, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002021
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Escherichia Coli Bacterin (USDA: 4585.20)" ;
    rdfs:seeAlso "USDA: 4585.20", "violinID:2532;2533;2534" ;
    rdfs:subClassOf obo:VO_0002377, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002022
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Escherichia Coli Bacterin (USDA: 4585.22)" ;
    rdfs:seeAlso "USDA: 4585.22", "violinID:2535;2536;2537" ;
    rdfs:subClassOf obo:VO_0002377, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002023
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 45B5.21)" ;
    rdfs:seeAlso "USDA: 45B5.21", "violinID:2538;2539;2540" ;
    rdfs:subClassOf obo:VO_0002378, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002024
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine-Haemophilus somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 4C95.20)" ;
    rdfs:seeAlso "USDA: 4C95.20", "violinID:2541;2542;2543;2544" ;
    rdfs:subClassOf obo:VO_0002379, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000058 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002025
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4595.21)" ;
    rdfs:seeAlso "USDA: 4595.21", "violinID:2545;2546" ;
    rdfs:subClassOf obo:VO_0002380, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002026
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4595.25)" ;
    rdfs:seeAlso "USDA: 4595.25", "violinID:2547;2548" ;
    rdfs:subClassOf obo:VO_0002380, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002027
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4599.00)" ;
    rdfs:seeAlso "USDA: 4599.00", "violinID:2549;2550" ;
    rdfs:subClassOf obo:VO_0002381, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002028
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 12A5.20)" ;
    rdfs:seeAlso "USDA: 12A5.20", "violinID:1360" ;
    rdfs:subClassOf obo:VO_0002486, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002029
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mannheimia Haemolytica-Pasteurella Multocida Avirulent Live Culture Vaccine (USDA: 1861.01)" ;
    rdfs:seeAlso "USDA: 1861.01", "violinID:1932;1933" ;
    rdfs:subClassOf obo:VO_0002446, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001014
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002030
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Fowl Pox-Mycoplasma Gallisepticum  Live Fowl Pox Vector, Live Virus Vaccine (USDA:1D61.R0)" ;
    rdfs:seeAlso "USDA:1D61.R0", "violinID:1143;1145;1144" ;
    rdfs:subClassOf obo:VO_0002328, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002031
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: )" ;
    rdfs:seeAlso "USDA:", "violinID:1437;1438" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002032
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Influenza-Fowl Pox H5 Subtype, Live Fowl Pox Vector Vaccine (USDA: 1061.R0)" ;
    rdfs:seeAlso "USDA: 1061.R0", "violinID:1161;1160" ;
    rdfs:subClassOf obo:VO_0002329, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002033
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Fowl Pox Live Virus Vaccine (USDA: 10M1.10 )" ;
    rdfs:seeAlso "USDA: 10M1.10", "violinID:1131;1130" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002034
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Fowl Pox Live Virus Vaccine (USDA: 10M1.11)" ;
    rdfs:seeAlso "USDA: 10M1.11", "violinID:1133;1132" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002035
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Fowl Pox Live Virus Vaccine (USDA: 10M1.13)" ;
    rdfs:seeAlso "USDA: 10M1.13", "violinID:1135;1134" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002036
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Fowl Pox Live Virus Vaccine (USDA: 10M1.14)" ;
    rdfs:seeAlso "USDA: 10M1.14", "violinID:1137;1136" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002037
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Fowl Pox Live Virus Vaccine (USDA: 10M1.40)" ;
    rdfs:seeAlso "USDA: 10M1.40", "violinID:1139;1138" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002038
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Fowl Pox-Laryngotracheitis Live Virus, Live Fowl Pox Vector Vaccine (USDA: 10S1.R0)" ;
    rdfs:seeAlso "USDA: 10S1.R0", "violinID:1141;1140;1142" ;
    rdfs:subClassOf obo:VO_0002327, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002039
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Avian Encephalomyelitis-Chicken Anemia Virus-Fowl Pox  Live and Modified Live Virus Vaccine (USDA: 10T1.40)" ;
    rdfs:seeAlso "USDA: 10T1.40", "violinID:1129;1128" ;
    rdfs:subClassOf obo:VO_0002325, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002040
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R0)" ;
    rdfs:seeAlso "USDA: 1281.R0", "violinID:1415;1416" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002041
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R1)" ;
    rdfs:seeAlso "USDA: 1281.R1", "violinID:1417;1418" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002042
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Variant, Serotype 3, Live Virus Vaccine (USDA: 1282.50)" ;
    rdfs:seeAlso "USDA: 1282.50", "violinID:1419;1420" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002043
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.42)" ;
    rdfs:seeAlso "USDA: 1288.42", "violinID:1421;1422" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002044
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.43)" ;
    rdfs:seeAlso "USDA: 1288.43", "violinID:1423;1424" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002045
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.44)" ;
    rdfs:seeAlso "USDA: 1288.44", "violinID:1425;1426" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002046
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.45)" ;
    rdfs:seeAlso "USDA: 1288.45", "violinID:1427;1428" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002047
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.4A)" ;
    rdfs:seeAlso "USDA: 1288.4A", "violinID:1429;1430" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002048
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.50)" ;
    rdfs:seeAlso "USDA: 12C2.50", "violinID:1431;1432" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002049
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.51)" ;
    rdfs:seeAlso "USDA: 12C2.51", "violinID:1433;1434" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002050
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Variant Strain, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.52)" ;
    rdfs:seeAlso "USDA: 12C2.52", "violinID:1435;1436" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002051
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.40)" ;
    rdfs:seeAlso "USDA: 12C8.40", "violinID:1439;1440" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002052
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.42)" ;
    rdfs:seeAlso "USDA: 12C8.42", "violinID:1441;1442" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002053
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.43)" ;
    rdfs:seeAlso "USDA: 12C8.43", "violinID:1443;1444" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002054
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.44)" ;
    rdfs:seeAlso "USDA: 12C8.44", "violinID:1445;1446" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002055
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.01)" ;
    rdfs:seeAlso "USDA: 12D5.01", "violinID:1539;1540" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002056
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Killed Virus Vaccine (USDA: 12D5.02)" ;
    rdfs:seeAlso "USDA: 12D5.02", "violinID:1541;1542" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002057
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.03)" ;
    rdfs:seeAlso "USDA: 12D5.03", "violinID:1543;1544" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002058
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.04)" ;
    rdfs:seeAlso "USDA: 12D5.04", "violinID:1545;1546" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002059
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.30)" ;
    rdfs:seeAlso "USDA: 12D5.30", "violinID:1547;1548" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002060
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12D5.45)" ;
    rdfs:seeAlso "USDA: 12D5.45", "violinID:1467;1465;1466" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002061
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.E0)" ;
    rdfs:seeAlso "USDA: 12D5.E0", "violinID:1549;1550" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002062
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.F0)" ;
    rdfs:seeAlso "USDA: 12D5.F0", "violinID:1551;1552" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002063
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.F1)" ;
    rdfs:seeAlso "USDA: 12D5.F1", "violinID:1553;1554" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002064
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.T0)" ;
    rdfs:seeAlso "USDA: 12D5.T0", "violinID:1555;1556" ;
    rdfs:subClassOf obo:VO_0002385, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002065
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.10)" ;
    rdfs:seeAlso "USDA: 12G5.10", "violinID:1457;1458" ;
    rdfs:subClassOf obo:VO_0002365, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002066
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.11)" ;
    rdfs:seeAlso "USDA: 12G5.11", "violinID:1459;1460" ;
    rdfs:subClassOf obo:VO_0002365, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002067
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease Standard & Variant, Killed Virus Vaccine (USDA: 12G5.42)" ;
    rdfs:seeAlso "USDA: 12G5.42", "violinID:1461;1462" ;
    rdfs:subClassOf obo:VO_0002365, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002068
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.43)" ;
    rdfs:seeAlso "USDA: 12G5.43", "violinID:1463;1464" ;
    rdfs:subClassOf obo:VO_0002365, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002069
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.4M)" ;
    rdfs:seeAlso "USDA: 12H1.4M", "violinID:1469;1468;1470" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002070
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.67)" ;
    rdfs:seeAlso "USDA: 12H1.67", "violinID:1471;1473;1472" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002071
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.40)" ;
    rdfs:seeAlso "USDA: 12J5.40", "violinID:1475;1474;1476" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002072
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.43)" ;
    rdfs:seeAlso "USDA: 12J5.43", "violinID:1477;1479;1478" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002073
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12J5.61)" ;
    rdfs:seeAlso "USDA: 12J5.61", "violinID:1481;1480;1482" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002074
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.62)" ;
    rdfs:seeAlso "USDA: 12J5.62", "violinID:1483;1485;1484" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002075
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus  Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.00)" ;
    rdfs:seeAlso "USDA: 12M5.00", "violinID:1487;1489;1486;1488" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002076
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus  Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.01)" ;
    rdfs:seeAlso "USDA: 12M5.01", "violinID:1491;1493;1490;1492" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002077
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.11)" ;
    rdfs:seeAlso "USDA: 12M5.11", "violinID:1495;1497;1494;1496" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002078
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Killed Virus Vaccine (USDA: 12M5.40)" ;
    rdfs:seeAlso "USDA: 12M5.40", "violinID:1499;1501;1500;1498" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002079
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.41)" ;
    rdfs:seeAlso "USDA: 12M5.41", "violinID:1503;1505;1502;1504" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002080
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.42)" ;
    rdfs:seeAlso "USDA: 12M5.42", "violinID:1507;1509;1506;1508" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002081
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.43)" ;
    rdfs:seeAlso "USDA: 12M5.43", "violinID:1511;1513;1510;1512" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002082
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.50)" ;
    rdfs:seeAlso "USDA: 12M5.50", "violinID:1517;1515;1516;1514" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002083
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.90)" ;
    rdfs:seeAlso "USDA: 12M5.90", "violinID:1519;1521;1518;1520" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002084
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.91)" ;
    rdfs:seeAlso "USDA: 12M5.91", "violinID:1523;1525;1522;1524" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002085
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.E0)" ;
    rdfs:seeAlso "USDA: 12M5.E0", "violinID:1527;1529;1526;1528" ;
    rdfs:subClassOf obo:VO_0002383, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002086
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.40)" ;
    rdfs:seeAlso "USDA: 12P5.40", "violinID:1531;1532;1530" ;
    rdfs:subClassOf obo:VO_0002384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002087
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.41)" ;
    rdfs:seeAlso "USDA: 12P5.41", "violinID:1533;1535;1534" ;
    rdfs:subClassOf obo:VO_0002384, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002088
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.E0)" ;
    rdfs:seeAlso "USDA: 12P5.E0", "violinID:1537;1536;1538" ;
    rdfs:subClassOf obo:VO_0002384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002089
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Adenovirus Type 2-Parainfluenza-Bordetella Bronchiseptica Modified Live Virus & Avirulent Live Culture Vaccine (USDA: 12X1.20)" ;
    rdfs:seeAlso "USDA: 12X1.20", "violinID:1559;1558;1560" ;
    rdfs:subClassOf obo:VO_0002386, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002090
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.20)" ;
    rdfs:seeAlso "USDA: 1331.20", "violinID:1657;1659;1658" ;
    rdfs:subClassOf obo:VO_0002413, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002091
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.25)" ;
    rdfs:seeAlso "USDA: 1331.25", "violinID:1661;1660;1662" ;
    rdfs:subClassOf obo:VO_0002413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002092
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.27)" ;
    rdfs:seeAlso "USDA: 1331.27", "violinID:1665;1663;1664" ;
    rdfs:subClassOf obo:VO_0002413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002093
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.30)" ;
    rdfs:seeAlso "USDA: 1331.30", "violinID:1667;1666;1668" ;
    rdfs:subClassOf obo:VO_0002413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002094
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus, Canarypox Vector Vaccine (USDA: 1331.R1)" ;
    rdfs:seeAlso "USDA: 1331.R1", "violinID:1669;1671;1670" ;
    rdfs:subClassOf obo:VO_0002413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002095
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Measles-Parainfluenza Modified Live Virus Vaccine (USDA: 1341.20)" ;
    rdfs:seeAlso "USDA: 1341.20", "violinID:1605;1607;1606;1608" ;
    rdfs:subClassOf obo:VO_0002406, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002096
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Measles Modified Live Virus Vaccine (USDA: 1351.20)" ;
    rdfs:seeAlso "USDA: 1351.20", "violinID:1685;1686" ;
    rdfs:subClassOf obo:VO_0002416, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002097
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Hepatitis-Parainfluenza Modified Live Virus Vaccine (USDA: 1381.21)" ;
    rdfs:seeAlso "USDA: 1381.21", "violinID:1683;1682;1684" ;
    rdfs:subClassOf obo:VO_0002415, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002098
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine (USDA: 13A1.20)" ;
    rdfs:seeAlso "USDA: 13A1.20", "violinID:1577;1576" ;
    rdfs:subClassOf obo:VO_0002394, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000062 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002099
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine (USDA: 13A1.27)" ;
    rdfs:seeAlso "USDA: 13A1.27", "violinID:1579;1578" ;
    rdfs:subClassOf obo:VO_0002394, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002100
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine (USDA: 13C1.20)" ;
    rdfs:seeAlso "USDA: 13C1.20", "violinID:1609;1611;1610" ;
    rdfs:subClassOf obo:VO_0002407, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002101
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.20)" ;
    rdfs:seeAlso "USDA: 13D1.20", "violinID:1615;1613;1612;1614" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000149 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002102
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.21)" ;
    rdfs:seeAlso "USDA: 13D1.21", "violinID:1617;1619;1616;1618" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002103
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.22)" ;
    rdfs:seeAlso "USDA: 13D1.22", "violinID:1621;1623;1620;1622" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002104
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.23)" ;
    rdfs:seeAlso "USDA: 13D1.23", "violinID:1625;1627;1624;1626" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002105
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.25)" ;
    rdfs:seeAlso "USDA: 13D1.25", "violinID:1631;1629;1628;1630" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002106
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.27)" ;
    rdfs:seeAlso "USDA: 13D1.27", "violinID:1633;1635;1632;1634" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002107
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.28)" ;
    rdfs:seeAlso "USDA: 13D1.28", "violinID:1637;1639;1636;1638" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002108
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.29)" ;
    rdfs:seeAlso "USDA: 13D1.29", "violinID:1641;1643;1640;1642" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002109
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Canarypox Vector Vaccine (USDA: 13D1.R1)" ;
    rdfs:seeAlso "USDA: 13D1.R1", "violinID:1645;1647;1644;1646" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002110
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.T0)" ;
    rdfs:seeAlso "USDA: 13D1.T0", "violinID:1649;1651;1648;1650" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002111
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus-Rabies Modified Live & Killed Virus Vaccine (USDA: 13G9.20)" ;
    rdfs:seeAlso "USDA: 13G9.20", "violinID:1653;1655;1652;1654;1656" ;
    rdfs:subClassOf obo:VO_0002466, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002112
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus-Rabies Modified Live & Killed Virus Vaccine (USDA: 13H9.20)" ;
    rdfs:seeAlso "USDA: 13H9.20", "violinID:1673;1675;1672;1674" ;
    rdfs:subClassOf obo:VO_0002414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002113
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.20)" ;
    rdfs:seeAlso "USDA: 13P1.20", "violinID:1687;1688" ;
    rdfs:subClassOf obo:VO_0002417, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002114
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.27)" ;
    rdfs:seeAlso "USDA: 13P1.27", "violinID:1689;1690" ;
    rdfs:subClassOf obo:VO_0002417, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002115
    obo:IAO_0000115 "A horse Encephalomyelitis-Influenza-West Nile Virus vaccine that is inactivated and manufactured by Wyeth Pharmaceuticals Inc. " ;
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza-West Nile Virus Eastern & Western, Killed Virus Vaccine (USDA: 13W5.20)" ;
    rdfs:seeAlso "USDA: 13W5.20", "violinID:1717;1719;1718;1720" ;
    rdfs:subClassOf obo:VO_0002483, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002116
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western, Killed Virus Vaccine (USDA: 1475.00)" ;
    rdfs:seeAlso "USDA: 1475.00", "violinID:1715;1716" ;
    rdfs:subClassOf obo:VO_0002424, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002117
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D7.20)" ;
    rdfs:seeAlso "USDA: 14D7.20", "violinID:1677;1676;1678" ;
    rdfs:subClassOf obo:VO_0002482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002118
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D9.27)" ;
    rdfs:seeAlso "USDA: 14D9.27", "violinID:1681;1679;1680" ;
    rdfs:subClassOf obo:VO_0002482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002119
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Parainfluenza-Bordetella Bronchiseptica Modified Live Virus, Avirulent Live Culture  Vaccine (USDA: 14M1.20)" ;
    rdfs:seeAlso "USDA: 14M1.20", "violinID:1693;1694" ;
    rdfs:subClassOf obo:VO_0002418, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002120
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Parainfluenza-Bordetella Bronchiseptica Modified Live Virus, Avirulent Live Culture  Vaccine (USDA: 14M1.22)" ;
    rdfs:seeAlso "USDA: 14M1.22", "violinID:1695;1696" ;
    rdfs:subClassOf obo:VO_0002418, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002121
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus-Parvovirus Modified Live Virus Vaccine (USDA: 14R1.20)" ;
    rdfs:seeAlso "USDA: 14R1.20", "violinID:1565;1564" ;
    rdfs:subClassOf obo:VO_0002393, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002122
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.20)" ;
    rdfs:seeAlso "USDA: 14R7.20", "violinID:1567;1566" ;
    rdfs:subClassOf obo:VO_0002393, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002123
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.21)" ;
    rdfs:seeAlso "USDA: 14R7.21", "violinID:1569;1568" ;
    rdfs:subClassOf obo:VO_0002393, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002124
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.22)" ;
    rdfs:seeAlso "USDA: 14R7.22", "violinID:1571;1570" ;
    rdfs:subClassOf obo:VO_0002393, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002125
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.25)" ;
    rdfs:seeAlso "USDA: 14R7.25", "violinID:1573;1572" ;
    rdfs:subClassOf obo:VO_0002393, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002126
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.29)" ;
    rdfs:seeAlso "USDA: 14R7.29", "violinID:1575;1574" ;
    rdfs:subClassOf obo:VO_0002393, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002127
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western, Killed Virus Vaccine (USDA: 14W5.22)" ;
    rdfs:seeAlso "USDA: 14W5.22", "violinID:1721;1723;1722" ;
    rdfs:subClassOf obo:VO_0002401, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002128
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western & Venezuelan, Killed Virus Vaccine (USDA: 14W5.23)" ;
    rdfs:seeAlso "USDA: 14W5.23", "violinID:1725;1727;1724;1726" ;
    rdfs:subClassOf obo:VO_0002431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002129
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western, Killed Virus, Live Canarypox Vector Vaccine (USDA: 14W7.R0)" ;
    rdfs:seeAlso "USDA: 14W7.R0", "violinID:1729;1728;1730" ;
    rdfs:subClassOf obo:VO_0002401, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002130
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis-Influenza Killed Virus Vaccine (USDA: 1515.24)" ;
    rdfs:seeAlso "USDA: 1515.24", "violinID:1747;1746" ;
    rdfs:subClassOf obo:VO_0002421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002131
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis-Influenza Killed Virus Vaccine (USDA: 1515.26)" ;
    rdfs:seeAlso "USDA: 1515.26", "violinID:1749;1748" ;
    rdfs:subClassOf obo:VO_0002421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002132
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis-Influenza Killed Virus Vaccine (USDA: 1515.27)" ;
    rdfs:seeAlso "USDA: 1515.27", "violinID:1751;1750" ;
    rdfs:subClassOf obo:VO_0002421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002133
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis-Influenza Killed Virus Vaccine (USDA: 1515.2A)" ;
    rdfs:seeAlso "USDA: 1515.2A", "violinID:1753;1752" ;
    rdfs:subClassOf obo:VO_0002421, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002134
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Equine Rhinopneumonitis-Influenza Modified Live & Killed Virus Vaccine (USDA: 1518.20)" ;
    rdfs:seeAlso "USDA: 1518.20", "violinID:1755;1754" ;
    rdfs:subClassOf obo:VO_0002421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002135
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus; Canarypox Vector Vaccine (USDA: 1591.R1)" ;
    rdfs:seeAlso "USDA: 1591.R1", "violinID:1583;1581;1582;1584;1580" ;
    rdfs:subClassOf obo:VO_0002395, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002136
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.20)" ;
    rdfs:seeAlso "USDA: 1599.20", "violinID:1585;1587;1589;1586;1588" ;
    rdfs:subClassOf obo:VO_0002395, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002137
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.21)" ;
    rdfs:seeAlso "USDA: 1599.21", "violinID:1591;1593;1590;1592;1594" ;
    rdfs:subClassOf obo:VO_0002395, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002138
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.25)" ;
    rdfs:seeAlso "USDA: 1599.25", "violinID:1599;1595;1597;1598;1596" ;
    rdfs:subClassOf obo:VO_0002395, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002139
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.29)" ;
    rdfs:seeAlso "USDA: 1599.29", "violinID:1601;1603;1600;1602;1604" ;
    rdfs:subClassOf obo:VO_0002395, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002140
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 15E2.00)" ;
    rdfs:seeAlso "USDA: 15E2.00", "violinID:1922;1921" ;
    rdfs:subClassOf obo:VO_0002444, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002141
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16J1.R1)" ;
    rdfs:seeAlso "USDA: 16J1.R1", "violinID:1910;1909" ;
    rdfs:subClassOf obo:VO_0002441, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002142
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis-Marek's Disease Serotypes 2 & 3, Modified Live & Live Marek's Disease Vector Vaccine (USDA: 16J1.R2)" ;
    rdfs:seeAlso "USDA: 16J1.R2", "violinID:1912;1911" ;
    rdfs:subClassOf obo:VO_0002441, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002143
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease-Newcastle Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16N1.R0)" ;
    rdfs:seeAlso "USDA: 16N1.R0", "violinID:1954;1953" ;
    rdfs:subClassOf obo:VO_0002447, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002144
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease-Newcastle Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R1)" ;
    rdfs:seeAlso "USDA: 16N1.R1", "violinID:1956;1955" ;
    rdfs:subClassOf obo:VO_0002447, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002145
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease-Newcastle Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R2)" ;
    rdfs:seeAlso "USDA: 16N1.R2", "violinID:1958;1957" ;
    rdfs:subClassOf obo:VO_0002447, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002146
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease-Tenosynovitis Serotypes 2 & 3, Live & Modified Live Virus Vaccine (USDA: 16T1.00)" ;
    rdfs:seeAlso "USDA: 16T1.00", "violinID:1964;1963" ;
    rdfs:subClassOf obo:VO_0002448, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002147
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease-Tenosynovitis Serotypes 2 & 3, Live Virus Vaccine (USDA: 16T1.03)" ;
    rdfs:seeAlso "USDA: 16T1.03", "violinID:1966;1965" ;
    rdfs:subClassOf obo:VO_0002448, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002148
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.11)" ;
    rdfs:seeAlso "USDA: 1761.11", "violinID:1996;1997" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002149
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.12)" ;
    rdfs:seeAlso "USDA: 1761.12", "violinID:1998;1999" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002150
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1761.13)" ;
    rdfs:seeAlso "USDA: 1761.13", "violinID:2000;2001" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002151
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.14)" ;
    rdfs:seeAlso "USDA: 1761.14", "violinID:2002;2003" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002152
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.15)" ;
    rdfs:seeAlso "USDA: 1761.15", "violinID:2004;2005" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002153
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.17)" ;
    rdfs:seeAlso "USDA: 1761.17", "violinID:2006;2007" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002154
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.18)" ;
    rdfs:seeAlso "USDA: 1761.18", "violinID:2008;2009" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002155
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.19)" ;
    rdfs:seeAlso "USDA: 1761.19", "violinID:2010;2011" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002156
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1761.1A)" ;
    rdfs:seeAlso "USDA: 1761.1A", "violinID:2012;2013" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002157
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1762.11)" ;
    rdfs:seeAlso "USDA: 1762.11", "violinID:2014;2015" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002158
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1762.13)" ;
    rdfs:seeAlso "USDA: 1762.13", "violinID:2016;2017" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002159
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1762.1H)" ;
    rdfs:seeAlso "USDA: 1762.1H", "violinID:2018;2019" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002160
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.11)" ;
    rdfs:seeAlso "USDA: 1771.11", "violinID:2020;2021" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002161
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.12)" ;
    rdfs:seeAlso "USDA: 1771.12", "violinID:2022;2023" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002162
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1771.14)" ;
    rdfs:seeAlso "USDA: 1771.14", "violinID:2024;2025" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002163
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1771.17)" ;
    rdfs:seeAlso "USDA: 1771.17", "violinID:2026;2027" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002164
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.18)" ;
    rdfs:seeAlso "USDA: 1771.18", "violinID:2028;2029" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001027 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002165
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.19)" ;
    rdfs:seeAlso "USDA: 1771.19", "violinID:2030;2031" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002166
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.1A)" ;
    rdfs:seeAlso "USDA: 1771.1A", "violinID:2032;2033" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002167
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1775.10)" ;
    rdfs:seeAlso "USDA: 1775.10", "violinID:2034;2035" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002168
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1775.11)" ;
    rdfs:seeAlso "USDA: 1775.11", "violinID:2036;2037" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002169
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1776.10)" ;
    rdfs:seeAlso "USDA: 1776.10", "violinID:2038;2039" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002170
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1785.10)" ;
    rdfs:seeAlso "USDA: 1785.10", "violinID:2040;2041" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002171
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1785.11)" ;
    rdfs:seeAlso "USDA: 1785.11", "violinID:2042;2043" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002172
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1785.12)" ;
    rdfs:seeAlso "USDA: 1785.12", "violinID:2044;2045" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002173
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1791.14)" ;
    rdfs:seeAlso "USDA: 1791.14", "violinID:2046;2047" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002174
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1791.15)" ;
    rdfs:seeAlso "USDA: 1791.15", "violinID:2048;2049" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002175
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1791.19)" ;
    rdfs:seeAlso "USDA: 1791.19", "violinID:2050;2051" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002176
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 1791.1X)" ;
    rdfs:seeAlso "USDA: 1791.1X", "violinID:2054;2055;2052;2053" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002177
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A1.1M)" ;
    rdfs:seeAlso "USDA: 17A1.1M", "violinID:2056;2057" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002178
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A1.1N)" ;
    rdfs:seeAlso "USDA: 17A1.1N", "violinID:2058;2059" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002179
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A2.1M)" ;
    rdfs:seeAlso "USDA: 17A2.1M", "violinID:2060;2061" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002180
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types Vaccine (USDA: 17B1.17)" ;
    rdfs:seeAlso "USDA: 17B1.17", "violinID:2062;2063" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002181
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease-Fowl Pox Live Fowl Pox Vector Vaccine (USDA: 17C1.R0)" ;
    rdfs:seeAlso "USDA: 17C1.R0", "violinID:1994;1995" ;
    rdfs:subClassOf obo:VO_0002456, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002182
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R1)" ;
    rdfs:seeAlso "USDA: 17H1.R1", "violinID:1960;1959" ;
    rdfs:subClassOf obo:VO_0002447, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002183
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R2)" ;
    rdfs:seeAlso "USDA: 17H1.R2", "violinID:1962;1961" ;
    rdfs:subClassOf obo:VO_0002447, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002184
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Paramyxovirus Type 3, Killed Virus Vaccine (USDA: 17P5.10)" ;
    rdfs:seeAlso "USDA: 17P5.10", "violinID:2072;2073" ;
    rdfs:subClassOf obo:VO_0002458, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002185
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis VG/GA Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 17V1.10)" ;
    rdfs:seeAlso "USDA: 17V1.10", "violinID:2064;2065" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002186
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis VG/GA Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 17V1.11)" ;
    rdfs:seeAlso "USDA: 17V1.11", "violinID:2066;2067" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002187
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.12)" ;
    rdfs:seeAlso "USDA: 19A5.12", "violinID:2128" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002188
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.22)" ;
    rdfs:seeAlso "USDA: 19A5.22", "violinID:2129" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002189
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.23)" ;
    rdfs:seeAlso "USDA: 19A5.23", "violinID:2130" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002190
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.24)" ;
    rdfs:seeAlso "USDA: 19A5.24", "violinID:2131" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002191
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.26)" ;
    rdfs:seeAlso "USDA: 19A5.26", "violinID:2132" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002192
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine (USDA: 19A5.29)" ;
    rdfs:seeAlso "USDA: 19A5.29", "violinID:2133" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002193
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Modified Live Virus Vaccine (USDA: 19H1.20)" ;
    rdfs:seeAlso "USDA: 19H1.20", "violinID:2106;2105" ;
    rdfs:subClassOf obo:VO_0002475, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002194
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Circovirus Type 2, Killed Baculovirus Vector Vaccine (USDA: 19K5.R0)" ;
    rdfs:seeAlso "USDA: 19K5.R0", "violinID:2096" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002195
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Circovirus Type 1 - Type 2 Chimera, Killed Virus Vaccine (USDA: 19K5.R1)" ;
    rdfs:seeAlso "USDA: 19K5.R1", "violinID:2097" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002196
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1A82.50)" ;
    rdfs:seeAlso "USDA: 1A82.50", "violinID:1447;1448" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002197
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 1A88.R0)" ;
    rdfs:seeAlso "USDA: 1A88.R0", "violinID:1449;1450" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002198
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R1)" ;
    rdfs:seeAlso "USDA: 1A88.R1", "violinID:1451;1452" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002199
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R2)" ;
    rdfs:seeAlso "USDA: 1A88.R2", "violinID:1453;1454" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002200
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1B82.50)" ;
    rdfs:seeAlso "USDA: 1B82.50", "violinID:1455;1456" ;
    rdfs:subClassOf obo:VO_0002382, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002201
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox-Mycoplasma Gallisepticum Live Fowl Pox Vector Vaccine (USDA: 1D51.R0)" ;
    rdfs:seeAlso "USDA: 1D51.R0", "violinID:1924;1923" ;
    rdfs:subClassOf obo:VO_0002445, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002202
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox-Laryngotracheitis Live Fowl Pox Vector Vaccine (USDA: 1F31.R0)" ;
    rdfs:seeAlso "USDA: 1F31.R0", "violinID:1920;1919" ;
    rdfs:subClassOf obo:VO_0002443, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002203
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, C2 Strain, Mass Type, Live Virus Vaccine (USDA: 1XB1.10)" ;
    rdfs:seeAlso "USDA: 1XB1.10", "violinID:2068;2069" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002204
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis B1 Type, C2 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1XC1.10)" ;
    rdfs:seeAlso "USDA: 1XC1.10", "violinID:2070;2071" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002205
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus somnus Bacterin (USDA: 40A5.20)" ;
    rdfs:seeAlso "USDA: 40A5.20", "violinID:2150;2151" ;
    rdfs:subClassOf obo:VO_0002489, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002206
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4629.20)" ;
    rdfs:seeAlso "USDA: 4629.20", "violinID:2574;2576;2575" ;
    rdfs:subClassOf obo:VO_0002397, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002207
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4629.27)" ;
    rdfs:seeAlso "USDA: 4629.27", "violinID:2572;2573;2571" ;
    rdfs:subClassOf obo:VO_0002396, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002208
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.20)" ;
    rdfs:seeAlso "USDA: 4637.20", "violinID:2698;2697;2696;2700;2699" ;
    rdfs:subClassOf obo:VO_0002412, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002209
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.22)" ;
    rdfs:seeAlso "USDA: 4637.22", "violinID:2704;2702;2705;2701;2703" ;
    rdfs:subClassOf obo:VO_0002412, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002210
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.23)" ;
    rdfs:seeAlso "USDA: 4637.23", "violinID:2706;2708;2710;2707;2709" ;
    rdfs:subClassOf obo:VO_0002412, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002211
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4637.29)" ;
    rdfs:seeAlso "USDA: 4637.29", "violinID:2672;2674;2671;2673;2675" ;
    rdfs:subClassOf obo:VO_0002409, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002212
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.21)" ;
    rdfs:seeAlso "USDA: 4639.21", "violinID:2712;2714;2711;2713;2715" ;
    rdfs:subClassOf obo:VO_0002412, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002213
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.22)" ;
    rdfs:seeAlso "USDA: 4639.22", "violinID:2716;2718;2720;2717;2719" ;
    rdfs:subClassOf obo:VO_0002412, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002214
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4639.25)" ;
    rdfs:seeAlso "USDA: 4639.25", "violinID:2676;2678;2680;2677;2679" ;
    rdfs:subClassOf obo:VO_0002409, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002215
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.27)" ;
    rdfs:seeAlso "USDA: 4639.27", "violinID:2688;2690;2686;2689;2687" ;
    rdfs:subClassOf obo:VO_0002411, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002216
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.28)" ;
    rdfs:seeAlso "USDA: 4639.28", "violinID:2692;2694;2691;2693;2695" ;
    rdfs:subClassOf obo:VO_0002411, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002217
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.R1)" ;
    rdfs:seeAlso "USDA: 4639.R1", "violinID:2722;2724;2721;2723;2725" ;
    rdfs:subClassOf obo:VO_0002404, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002218
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4659.20)" ;
    rdfs:seeAlso "USDA: 4659.20", "violinID:2668;2670;2667;2669" ;
    rdfs:subClassOf obo:VO_0002425, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002219
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46B9.21)" ;
    rdfs:seeAlso "USDA: 46B9.21", "violinID:2590;2592;2594;2589;2591;2593;2595" ;
    rdfs:subClassOf obo:VO_0002399, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002220
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46D5.27)" ;
    rdfs:seeAlso "USDA: 46D5.27", "violinID:1154;1159" ;
    rdfs:subClassOf obo:VO_0002391, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002221
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46E5.20)" ;
    rdfs:seeAlso "USDA: 46E5.20", "violinID:1153;1158" ;
    rdfs:subClassOf obo:VO_0002390, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002222
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.21)" ;
    rdfs:seeAlso "USDA: 46E5.21", "violinID:1145;1144" ;
    rdfs:subClassOf obo:VO_0002389, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002223
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.23)" ;
    rdfs:seeAlso "USDA: 46E5.23", "violinID:1150;1151" ;
    rdfs:subClassOf obo:VO_0002390, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002224
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.24)" ;
    rdfs:seeAlso "USDA: 46E5.24", "violinID:1147;1149" ;
    rdfs:subClassOf obo:VO_0002389, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002225
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.25)" ;
    rdfs:seeAlso "USDA: 46E5.25", "violinID:1152;1146" ;
    rdfs:subClassOf obo:VO_0002390, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002226
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.20)" ;
    rdfs:seeAlso "USDA: 46J7.20", "violinID:2632;2634;2636;2633;2635;2637" ;
    rdfs:subClassOf obo:VO_0002403, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002227
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.22)" ;
    rdfs:seeAlso "USDA: 46J7.22", "violinID:2640;2642;2638;2639;2641;2643" ;
    rdfs:subClassOf obo:VO_0002403, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002228
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J8.20)" ;
    rdfs:seeAlso "USDA: 46J8.20", "violinID:2726;2728;2730;2727;2729" ;
    rdfs:subClassOf obo:VO_0002412, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002229
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.20)" ;
    rdfs:seeAlso "USDA: 46J9.20", "violinID:2644;2646;2648;2645;2647;2649" ;
    rdfs:subClassOf obo:VO_0002403, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002230
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.21)" ;
    rdfs:seeAlso "USDA: 46J9.21", "violinID:2614;2616;2618;2615;2617;2619" ;
    rdfs:subClassOf obo:VO_0002487, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002231
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.25)" ;
    rdfs:seeAlso "USDA: 46J9.25", "violinID:2596;2598;2600;2597;2599;2601" ;
    rdfs:subClassOf obo:VO_0002400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002232
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.26)" ;
    rdfs:seeAlso "USDA: 46J9.26", "violinID:2622;2624;2620;2623;2625;2621" ;
    rdfs:subClassOf obo:VO_0002487, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002233
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.27)" ;
    rdfs:seeAlso "USDA: 46J9.27", "violinID:2626;2628;2630;2627;2629;2631" ;
    rdfs:subClassOf obo:VO_0002487, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002234
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.29)" ;
    rdfs:seeAlso "USDA: 46J9.29", "violinID:2606;2602;2604;2607;2603;2605" ;
    rdfs:subClassOf obo:VO_0002400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002235
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.R1)" ;
    rdfs:seeAlso "USDA: 46J9.R1", "violinID:2650;2652;2654;2655;2651;2653" ;
    rdfs:subClassOf obo:VO_0002403, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002236
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.27)" ;
    rdfs:seeAlso "USDA: 46L9.27", "violinID:2656;2658;2660;2657;2659;2661" ;
    rdfs:subClassOf obo:VO_0002404, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002237
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46P9.27)" ;
    rdfs:seeAlso "USDA: 46P9.27", "violinID:2662;2664;2666;2663;2665" ;
    rdfs:subClassOf obo:VO_0002405, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002238
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza-West Nile Virus Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 46W5.21)" ;
    rdfs:seeAlso "USDA: 46W5.21", "violinID:2800;2799;2801" ;
    rdfs:subClassOf obo:VO_0002423, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002239
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47A5.20)" ;
    rdfs:seeAlso "USDA: 47A5.20", "violinID:1137;1136" ;
    rdfs:subClassOf obo:VO_0002392, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002240
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Parvovirus Modified Live Virus Vaccine-Leptospira Canicola Icterohaemorrhagiae Bacterin (USDA: 47B1.20)" ;
    rdfs:seeAlso "USDA: 47B1.20", "violinID:2738;2739" ;
    rdfs:subClassOf obo:VO_0002419, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002241
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.20)" ;
    rdfs:seeAlso "USDA: 47C5.20", "violinID:2578;2580;2582;2577;2579;2581" ;
    rdfs:subClassOf obo:VO_0002398, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002242
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.29)" ;
    rdfs:seeAlso "USDA: 47C5.29", "violinID:2584;2586;2588;2583;2585;2587" ;
    rdfs:subClassOf obo:VO_0002398, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002243
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 47E5.20)" ;
    rdfs:seeAlso "USDA: 47E5.20", "violinID:1140;1142;1143" ;
    rdfs:subClassOf obo:VO_0002388, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002244
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 47E5.21)" ;
    rdfs:seeAlso "USDA: 47E5.21", "violinID:1139;1138;1141" ;
    rdfs:subClassOf obo:VO_0002387, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001001 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002245
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47K1.20)" ;
    rdfs:seeAlso "USDA: 47K1.20", "violinID:2682;2684;2681;2683;2685" ;
    rdfs:subClassOf obo:VO_0002410, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002246
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47L9.20)" ;
    rdfs:seeAlso "USDA: 47L9.20", "violinID:2608;2610;2612;2609;2611;2613" ;
    rdfs:subClassOf obo:VO_0002402, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002247
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Hepatitis-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47P9.22)" ;
    rdfs:seeAlso "USDA: 47P9.22", "violinID:2732;2734;2731;2733;2735" ;
    rdfs:subClassOf obo:VO_0002426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002248
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4835.20)" ;
    rdfs:seeAlso "USDA: 4835.20", "violinID:2768;2770;2769" ;
    rdfs:subClassOf obo:VO_0002422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002249
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4835.23)" ;
    rdfs:seeAlso "USDA: 4835.23", "violinID:2772;2771;2773" ;
    rdfs:subClassOf obo:VO_0002422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002250
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4835.24)" ;
    rdfs:seeAlso "USDA: 4835.24", "violinID:2774;2776;2775" ;
    rdfs:subClassOf obo:VO_0002422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002251
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4835.45)" ;
    rdfs:seeAlso "USDA: 4835.45", "violinID:2778;2777;2779" ;
    rdfs:subClassOf obo:VO_0002422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002252
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4835.46)" ;
    rdfs:seeAlso "USDA: 4835.46", "violinID:2780;2782;2781" ;
    rdfs:subClassOf obo:VO_0002422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002253
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4844.30)" ;
    rdfs:seeAlso "USDA: 4844.30", "violinID:2804;2802;2805;2803" ;
    rdfs:subClassOf obo:VO_0002428, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002254
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4845.23)" ;
    rdfs:seeAlso "USDA: 4845.23", "violinID:2806;2808;2810;2807;2809" ;
    rdfs:subClassOf obo:VO_0002429, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002255
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4845.24)" ;
    rdfs:seeAlso "USDA: 4845.24", "violinID:2812;2814;2811;2813;2815" ;
    rdfs:subClassOf obo:VO_0002429, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002256
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4845.32)" ;
    rdfs:seeAlso "USDA: 4845.32", "violinID:2820;2816;2818;2817;2819" ;
    rdfs:subClassOf obo:VO_0002429, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002257
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4845.33)" ;
    rdfs:seeAlso "USDA: 4845.33", "violinID:2822;2824;2821;2823;2825" ;
    rdfs:subClassOf obo:VO_0002429, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002258
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4847.22)" ;
    rdfs:seeAlso "USDA: 4847.22", "violinID:2826;2828;2830;2827;2829;2831" ;
    rdfs:subClassOf obo:VO_0000542, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002259
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4847.23)" ;
    rdfs:seeAlso "USDA: 4847.23", "violinID:2832;2834;2836;2837;2833;2835" ;
    rdfs:subClassOf obo:VO_0000542, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002260
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4847.24)" ;
    rdfs:seeAlso "USDA: 4847.24", "violinID:2838;2840;2842;2839;2841;2843" ;
    rdfs:subClassOf obo:VO_0000542, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002261
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4847.32)" ;
    rdfs:seeAlso "USDA: 4847.32", "violinID:2844;2846;2848;2845;2847;2849" ;
    rdfs:subClassOf obo:VO_0000542, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002262
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Rhinopneumonitis-Influenza-West Nile Virus Eastern & Western, Killed Virus, Killed Flavivirus Chimera Vaccine-Tetanus Toxoid (USDA: 4855.R2)" ;
    rdfs:seeAlso "USDA: 4855.R2", "violinID:2854;2850;2852;2853;2855;2851" ;
    rdfs:subClassOf obo:VO_0002430, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002263
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4865.00)" ;
    rdfs:seeAlso "USDA: 4865.00", "violinID:2740;2742;2741" ;
    rdfs:subClassOf obo:VO_0002420, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000890 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001119 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002264
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4865.01)" ;
    rdfs:seeAlso "USDA: 4865.01", "violinID:2744;2743;2745" ;
    rdfs:subClassOf obo:VO_0002420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002265
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4865.21)" ;
    rdfs:seeAlso "USDA: 4865.21", "violinID:2746;2748;2747" ;
    rdfs:subClassOf obo:VO_0002420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002266
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4865.23)" ;
    rdfs:seeAlso "USDA: 4865.23", "violinID:2750;2752;2749;2751" ;
    rdfs:subClassOf obo:VO_0000541, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002267
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4865.26)" ;
    rdfs:seeAlso "USDA: 4865.26", "violinID:2754;2755;2753" ;
    rdfs:subClassOf obo:VO_0002420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002268
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4865.27)" ;
    rdfs:seeAlso "USDA: 4865.27", "violinID:2756;2758;2757;2759" ;
    rdfs:subClassOf obo:VO_0000541, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002269
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4867.20)" ;
    rdfs:seeAlso "USDA: 4867.20", "violinID:2760;2762;2761;2763" ;
    rdfs:subClassOf obo:VO_0000541, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002270
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4867.21)" ;
    rdfs:seeAlso "USDA: 4867.21", "violinID:2764;2766;2765;2767" ;
    rdfs:subClassOf obo:VO_0000541, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002271
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4875.23)" ;
    rdfs:seeAlso "USDA: 4875.23", "violinID:2784;2786;2783;2785" ;
    rdfs:subClassOf obo:VO_0000539, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002272
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4875.24)" ;
    rdfs:seeAlso "USDA: 4875.24", "violinID:2788;2790;2787;2789" ;
    rdfs:subClassOf obo:VO_0000539, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002273
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4875.A0)" ;
    rdfs:seeAlso "USDA: 4875.A0", "violinID:2792;2794;2791;2793" ;
    rdfs:subClassOf obo:VO_0000539, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002274
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-Influenza Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 4875.A1)" ;
    rdfs:seeAlso "USDA: 4875.A1", "violinID:2796;2798;2795;2797" ;
    rdfs:subClassOf obo:VO_0000539, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002275
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Mycoplasma Gallisepticum Bacterin (USDA: 48B5.10)" ;
    rdfs:seeAlso "USDA: 48B5.10", "violinID:2912;2911;2913" ;
    rdfs:subClassOf obo:VO_0002454, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002276
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Mycoplasma Gallisepticum Bacterin (USDA: 48B6.10)" ;
    rdfs:seeAlso "USDA: 48B6.10", "violinID:2914;2916;2915" ;
    rdfs:subClassOf obo:VO_0002454, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002277
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.01)" ;
    rdfs:seeAlso "USDA: 48C5.01", "violinID:2934;2933;2935" ;
    rdfs:subClassOf obo:VO_0002461, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002278
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.20)" ;
    rdfs:seeAlso "USDA: 48C5.20", "violinID:2936;2938;2937" ;
    rdfs:subClassOf obo:VO_0002461, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002279
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.21)" ;
    rdfs:seeAlso "USDA: 48C5.21", "violinID:2940;2939;2941" ;
    rdfs:subClassOf obo:VO_0002461, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000570 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000901 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002280
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.22)" ;
    rdfs:seeAlso "USDA: 48C5.22", "violinID:2942;2944;2943" ;
    rdfs:subClassOf obo:VO_0002461, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002281
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D6.10)" ;
    rdfs:seeAlso "USDA: 48D6.10", "violinID:2918;2919;2917" ;
    rdfs:subClassOf obo:VO_0002453, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0001001 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002282
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease-Bronchitis Mass & Ark Types, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D7.10)" ;
    rdfs:seeAlso "USDA: 48D7.10", "violinID:2906;2905;2907" ;
    rdfs:subClassOf obo:VO_0002453, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002283
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease-Bronchitis Mass & Ark Types, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D7.11)" ;
    rdfs:seeAlso "USDA: 48D7.11", "violinID:2908;2910;2909" ;
    rdfs:subClassOf obo:VO_0002453, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001027 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002284
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 48W5.20)" ;
    rdfs:seeAlso "USDA: 48W5.20", "violinID:2856;2858;2860;2857;2859" ;
    rdfs:subClassOf obo:VO_0002431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002285
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 48W5.21)" ;
    rdfs:seeAlso "USDA: 48W5.21", "violinID:2862;2864;2861;2863" ;
    rdfs:subClassOf obo:VO_0002431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002286
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western, Killed Virus Vaccine-Tetanus Toxoid (USDA: 48W5.22)" ;
    rdfs:seeAlso "USDA: 48W5.22", "violinID:2866;2868;2865;2867" ;
    rdfs:subClassOf obo:VO_0002431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002287
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western & Venezuelan, Killed Virus Vaccine-Tetanus Toxoid (USDA: 48W5.23)" ;
    rdfs:seeAlso "USDA: 48W5.23", "violinID:2870;2872;2871;2873;2869" ;
    rdfs:subClassOf obo:VO_0002431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002288
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Encephalomyelitis-West Nile Virus Eastern & Western, Killed Virus, Live Canarypox Vector Vaccine-Tetanus Toxoid (USDA: 48W9.R0)" ;
    rdfs:seeAlso "USDA: 48W9.R0", "violinID:2874;2876;2875;2877" ;
    rdfs:subClassOf obo:VO_0002431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002289
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Killed Virus Vaccine-Ehrlichia Risticii Bacterin (USDA: 4905.20)" ;
    rdfs:seeAlso "USDA: 4905.20", "violinID:3010" ;
    rdfs:subClassOf obo:VO_0002476, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0001119 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002290
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae Bacterin (USDA: 4906.20)" ;
    rdfs:seeAlso "USDA: 4906.20", "violinID:2922;2923" ;
    rdfs:subClassOf obo:VO_0002485, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002291
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4960.00)" ;
    rdfs:seeAlso "USDA: 4960.00", "violinID:2952;2951" ;
    rdfs:subClassOf obo:VO_0002463, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002292
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.01)" ;
    rdfs:seeAlso "USDA: 4975.01", "violinID:2946;2945" ;
    rdfs:subClassOf obo:VO_0002462, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002293
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.20)" ;
    rdfs:seeAlso "USDA: 4975.20", "violinID:2948;2947" ;
    rdfs:subClassOf obo:VO_0002462, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002294
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.22)" ;
    rdfs:seeAlso "USDA: 4975.22", "violinID:2950;2949" ;
    rdfs:subClassOf obo:VO_0002462, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002295
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4989.00)" ;
    rdfs:seeAlso "USDA: 4989.00", "violinID:2920;2921" ;
    rdfs:subClassOf obo:VO_0002459, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002296
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Trichomonas Foetus Vaccine, Killed Protozoa-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4990.00)" ;
    rdfs:seeAlso "USDA: 4990.00", "violinID:3036;3035;3037" ;
    rdfs:subClassOf obo:VO_0002481, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002297
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae Bacterin (USDA: 4993.20)" ;
    rdfs:seeAlso "USDA: 4993.20", "violinID:3012;3011" ;
    rdfs:subClassOf obo:VO_0002478, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002298
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae Bacterin (USDA: 4993.21)" ;
    rdfs:seeAlso "USDA: 4993.21", "violinID:3014;3013" ;
    rdfs:subClassOf obo:VO_0002478, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002299
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Mycoplasma Hyopneumoniae Bacterin (USDA: 4994.20)" ;
    rdfs:seeAlso "USDA: 4994.20", "violinID:3016;3015;3017" ;
    rdfs:subClassOf obo:VO_0002479, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002300
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Mycoplasma Hyopneumoniae Bacterin (USDA: 4994.21)" ;
    rdfs:seeAlso "USDA: 4994.21", "violinID:3018;3020;3019" ;
    rdfs:subClassOf obo:VO_0002479, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002301
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Mycoplasma Hyopneumoniae Bacterin (USDA: 4994.23)" ;
    rdfs:seeAlso "USDA: 4994.23", "violinID:3022;3021;3023" ;
    rdfs:subClassOf obo:VO_0002479, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002302
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Mycoplasma Hyopneumoniae Bacterin (USDA: 4994.24)" ;
    rdfs:seeAlso "USDA: 4994.24", "violinID:3024;3026;3025" ;
    rdfs:subClassOf obo:VO_0002479, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002303
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Mycoplasma Hyopneumoniae Bacterin (USDA: 4995.22)" ;
    rdfs:seeAlso "USDA: 4995.22", "violinID:3028;3027" ;
    rdfs:subClassOf obo:VO_0002480, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002304
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Mycoplasma Hyopneumoniae Bacterin (USDA: 4995.23)" ;
    rdfs:seeAlso "USDA: 4995.23", "violinID:3030;3029" ;
    rdfs:subClassOf obo:VO_0002480, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002305
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Mycoplasma Hyopneumoniae Bacterin (USDA: 4995.25)" ;
    rdfs:seeAlso "USDA: 4995.25", "violinID:3032;3031" ;
    rdfs:subClassOf obo:VO_0002480, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002306
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Mycoplasma Hyopneumoniae Bacterin (USDA: 4995.26)" ;
    rdfs:seeAlso "USDA: 4995.26", "violinID:3034;3033" ;
    rdfs:subClassOf obo:VO_0002480, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002307
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Modified Live Virus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid (USDA: 49B1.21)" ;
    rdfs:seeAlso "USDA: 49B1.21", "violinID:3004;3006;3003;3005" ;
    rdfs:subClassOf obo:VO_0002469, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002308
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus Modified Live Virus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid (USDA: 49C1.21)" ;
    rdfs:seeAlso "USDA: 49C1.21", "violinID:2992;2991;2993" ;
    rdfs:subClassOf obo:VO_0002471, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002309
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus  Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.22)" ;
    rdfs:seeAlso "USDA: 49F6.22", "violinID:2954;2956;2953;2955" ;
    rdfs:subClassOf obo:VO_0002464, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002310
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus  Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.23)" ;
    rdfs:seeAlso "USDA: 49F6.23", "violinID:2958;2960;2957;2959" ;
    rdfs:subClassOf obo:VO_0002464, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002311
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus  Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.24)" ;
    rdfs:seeAlso "USDA: 49F6.24", "violinID:2962;2964;2961;2963" ;
    rdfs:subClassOf obo:VO_0002464, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002312
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.22)" ;
    rdfs:seeAlso "USDA: 49G6.22", "violinID:2966;2968;2965;2967" ;
    rdfs:subClassOf obo:VO_0002465, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002313
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.23)" ;
    rdfs:seeAlso "USDA: 49G6.23", "violinID:2970;2972;2969;2971" ;
    rdfs:subClassOf obo:VO_0002465, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002314
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.24)" ;
    rdfs:seeAlso "USDA: 49G6.24", "violinID:2974;2976;2973;2975" ;
    rdfs:subClassOf obo:VO_0002465, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002315
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus Modified Live Virus Vaccine-Escherichia Coli Bacterin (USDA: 49K1.20)" ;
    rdfs:seeAlso "USDA: 49K1.20", "violinID:2994;2995" ;
    rdfs:subClassOf obo:VO_0002474, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002316
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Circovirus Type 2, Killed Baculovirus Vector Vaccine- Mycoplasma Hyopneumoniae Bacterin (USDA: 49K5.R1)" ;
    rdfs:seeAlso "USDA: 49K5.R1", "violinID:2978;2977" ;
    rdfs:subClassOf obo:VO_0002467, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002317
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome-Circovirus Reproductive & Respiratory Form, Type 2, Modifed Live Virus,Killed Baculovirus Vector Vaccine-Mycoplasma Hyopneumoniae Bacterin (USDA: 49K9.R0)" ;
    rdfs:seeAlso "USDA: 49K9.R0", "violinID:2986;2984;2985" ;
    rdfs:subClassOf obo:VO_0002472, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_85708
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002318
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Modified Live Virus Vaccine-Escherichia Coli Bacterin (USDA: 49P1.20)" ;
    rdfs:seeAlso "USDA: 49P1.20", "violinID:3008;3007;3009" ;
    rdfs:subClassOf obo:VO_0002470, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002319
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Modified Live Virus Vaccine-Bordetella Bronchiseptica-Clostridium Perfringens Type C-Erysipelothrix Rhusiopathiae-Escherichia Coli-Pasteurella Multocida Bacterin-Toxoid (USDA: 49T9.21)" ;
    rdfs:seeAlso "USDA: 49T9.21", "violinID:3002;2996;2998;3000;2997;2999;3001" ;
    rdfs:subClassOf obo:VO_0002468, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002320
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Infectious Salmon Anemia Virus Killed Virus Vaccine-Aeromonas Salmonicida-Vibrio Anguillarum-Ordalii-Salmonicida Bacterin  (USDA: 4A45.20)" ;
    rdfs:seeAlso "USDA: 4A45.20", "violinID:2878;2880;2879" ;
    rdfs:subClassOf obo:VO_0002442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002321
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.20)" ;
    rdfs:seeAlso "USDA: 4BC5.20", "violinID:2924;2926;2925" ;
    rdfs:subClassOf obo:VO_0002460, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000701 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002322
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.21)" ;
    rdfs:seeAlso "USDA: 4BC5.21", "violinID:2928;2927;2929" ;
    rdfs:subClassOf obo:VO_0002460, [
        a owl:Class ;
        owl:unionOf ([
                a owl:Restriction ;
                owl:hasValue obo:VO_0000204 ;
                owl:onProperty obo:OBI_0000304
            ]
            [
                a owl:Restriction ;
                owl:hasValue obo:VO_0000841 ;
                owl:onProperty obo:OBI_0000304
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0002323
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.22)" ;
    rdfs:seeAlso "USDA: 4BC5.22", "violinID:2930;2932;2931" ;
    rdfs:subClassOf obo:VO_0002460, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000841 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002324
    obo:IAO_0000116 "generated using OntoRat" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome-Parvovirus Reproductive Form, Modified Live & Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4P19.20)" ;
    rdfs:seeAlso "USDA: 4P19.20", "violinID:2988;2990;2987;2989" ;
    rdfs:subClassOf obo:VO_0002473, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002325
    a owl:Class ;
    rdfs:label "avian encephalomyelitis-chicken anemia virus-fowl pox vaccine" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12618
    ] .

obo:VO_0002326
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian encephalomyelitis-fowl pox vaccine" ;
    rdfs:subClassOf obo:VO_0001522, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10261
    ] .

obo:VO_0002327
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian encephalomyelitis-fowl pox-laryngotracheitis vaccine" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0002328
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian encephalomyelitis-fowl pox-Mycoplasma gallisepticum vaccine" ;
    rdfs:subClassOf obo:VO_0002326, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2096
    ] .

obo:VO_0002329
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "avian influenza-fowl pox vaccine" ;
    rdfs:subClassOf obo:VO_0000986, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10261
    ] .

obo:VO_0002330
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Parainfluenza 3-Respiratory Syncytial Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11215
    ] .

obo:VO_0002331
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0000987, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0002332
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002331, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_90371
    ] .

obo:VO_0002333
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae- Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002334 .

obo:VO_0002334
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002335 .

obo:VO_0002335
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Vaccine-Leptospira Hardjo-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002336 .

obo:VO_0002336
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis Vaccine-Leptospira Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0000987, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_94063
    ] .

obo:VO_0002337
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0002338
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "bovine rhinotracheitis-parainfluenza 3 vaccine" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000987
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11215
            ]
        )
    ] .

obo:VO_0002339
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Vaccine-Haemophilus Somnus Bacterin" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ] .

obo:VO_0002340
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Vaccine-Leptospira Canicola-Grippotyphosa-HardjoIcterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0002341
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002342 .

obo:VO_0002342
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3 Vaccine-Leptospira Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002336, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11215
    ] .

obo:VO_0002343
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0002338, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0002344
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Respiratory Syncytial Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0002345
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0002346
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine-Campylobacter Fetus-Leptospira CanicolaGrippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002349, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_196
    ] .

obo:VO_0002347
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002337, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ] .

obo:VO_0002348
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002347, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_90371
    ] .

obo:VO_0002349
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine-Leptospira Canicola-Grippotyphosa-HardjoIcterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002350 .

obo:VO_0002350
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002351 .

obo:VO_0002351
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine-Leptospira Hardjo-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002352 .

obo:VO_0002352
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea Vaccine-Leptospira Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002336, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ] .

obo:VO_0002353
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Vaccine" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11215
    ] .

obo:VO_0002354
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002352, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11215
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_196
    ] .

obo:VO_0002355
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002488 .

obo:VO_0002356
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002488, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002357
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Mannheimia Haemolytica Bacterin" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0002358
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0002372, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11215
    ] .

obo:VO_0002359
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-HardjoIcterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002360, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000570 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002360
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_196
    ] .

obo:VO_0002361
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Haemophilus Somnus Bacterin" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ] .

obo:VO_0002362
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002361, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0002363
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica Bacterin" ;
    rdfs:subClassOf obo:VO_0002357, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ] .

obo:VO_0002364
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002368, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] .

obo:VO_0002365
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "chicken bursal disease-Newcastle disease vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11176
    ] .

obo:VO_0002366
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona-Mannheimia Haemolytica Bacterin" ;
    rdfs:subClassOf obo:VO_0002364, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0002367
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis Vaccine" ;
    rdfs:subClassOf obo:VO_0002365, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ] .

obo:VO_0002368
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Leptospira Hardjo Bacterin" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0002369
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Mannheimia Haemolytica Toxoid" ;
    rdfs:subClassOf obo:VO_0002358, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0002370
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002371 .

obo:VO_0002371
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Vaccine" ;
    rdfs:subClassOf obo:VO_0002369, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0002372
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0002345, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0002373
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Vaccine-Leptospira Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002372, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_94063
    ] .

obo:VO_0002374
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10927
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11128
    ] .

obo:VO_0002375
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002377, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_79668
    ] .

obo:VO_0002376
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Vaccine-Clostridium Perfringens Types C & D-Escherichia Coli Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002375 .

obo:VO_0002377
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rotavirus-Coronavirus Vaccine-Escherichia Coli Bacterin" ;
    rdfs:subClassOf obo:VO_0002374, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_562
    ] .

obo:VO_0002378
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-HardjoIcterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_196
    ] .

obo:VO_0002379
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_75985
    ] .

obo:VO_0002380
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002381 .

obo:VO_0002381
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea Vaccine-Leptospira Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_94063
    ] .

obo:VO_0002382
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Mareks Disease Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10390
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0002383
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0002367, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ] .

obo:VO_0002384
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "chicken Bursal Disease-Newcastle Disease-Reovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0002365, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ] .

obo:VO_0002385
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "chicken bursal disease-reovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ] .

obo:VO_0002386
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Adenovirus Type 2-Parainfluenza-Bordetella Bronchiseptica Vaccine" ;
    rdfs:subClassOf obo:VO_0001490, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_518
    ] .

obo:VO_0002387
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-GrippotyphosaIcterohaemorrhagiae-Pomona Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002388 .

obo:VO_0002388
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002392, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0002389
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002390, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ] .

obo:VO_0002390
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002391, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_211880
    ] .

obo:VO_0002391
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_90062
    ] .

obo:VO_0002392
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus Vaccine-Borrelia Burgdorferi Bacterin" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0002393
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Coronavirus-Parvovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ] .

obo:VO_0002394
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2 Vaccine" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10514
    ] .

obo:VO_0002395
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ] .

obo:VO_0002396
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2 Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002397 .

obo:VO_0002397
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2 Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin" ;
    rdfs:subClassOf obo:VO_0002391, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10514
    ] .

obo:VO_0002398
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine-Borrelia Burgdorferi Bacterin" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10514
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ] .

obo:VO_0002399
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002400, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0002400
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002402 .

obo:VO_0002401
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "horse EEV, VEV, WEV encephalomyelitis and West Nile Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11039
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0002402
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002403 .

obo:VO_0002403
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin" ;
    rdfs:subClassOf obo:VO_0002404 .

obo:VO_0002404
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002405, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ] .

obo:VO_0002405
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10514
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11153
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_90062
    ] .

obo:VO_0002406
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Measles-Parainfluenza Vaccine" ;
    rdfs:subClassOf obo:VO_0002407, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11234
    ] .

obo:VO_0002407
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza Vaccine" ;
    rdfs:subClassOf obo:VO_0002394, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ] .

obo:VO_0002408
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0002407, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ] .

obo:VO_0002409
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine-Leptospira CanicolaGrippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002410, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0002410
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine-Leptospira CanicolaGrippotyphosa-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002411 .

obo:VO_0002411
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002412 .

obo:VO_0002412
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin" ;
    rdfs:subClassOf obo:VO_0002425, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ] .

obo:VO_0002413
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0002394, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ] .

obo:VO_0002414
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parvovirus-Rabies Vaccine" ;
    rdfs:subClassOf obo:VO_0002413, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0002415
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Hepatitis-Parainfluenza Vaccine" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10512
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ] .

obo:VO_0002416
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Measles Vaccine" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11234
    ] .

obo:VO_0002417
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Parvovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ] .

obo:VO_0002418
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "canine parainfluenza-bordetella bronchiseptica vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_518
    ] .

obo:VO_0002419
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "canine parvovirus vaccine-leptospira canicola icterohaemorrhagiae bacterin" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0002420
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "equine EEV and WEV encephalomyelitis vaccine-tetanus toxoid" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0001243 ;
                owl:someValuesFrom obo:NCBITaxon_9796
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11021
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11039
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_1485
            ]
        )
    ] .

obo:VO_0002421
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "equine rhinopneumonitis-influenza vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10326
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0002422
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "equine EEV and WEV encephalomyelitis-influenza vaccine-tetanus toxoid" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0002420
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11309
            ]
        )
    ] .

obo:VO_0002423
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "equine EEV and WEV encephalomyelitis-influenza-West Nile virus vaccine-tetanus toxoid" ;
    rdfs:subClassOf obo:VO_0002422, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0002424
    obo:IAO_0000115 "a viral vaccine against horse EEV, WEV, and VEE viral infections" ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "horse encephalomyelitis EEV, VEV, and WEV combination vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11039
    ] .

obo:VO_0002425
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin" ;
    rdfs:subClassOf obo:VO_0002397, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ] .

obo:VO_0002426
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Hepatitis-Parainfluenza-Parvovirus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin" ;
    rdfs:subClassOf obo:VO_0002415, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0002427
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Immunodeficiency-Leukemia Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11673
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11768
    ] .

obo:VO_0002428
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "equine EEV and WEV encephalomyelitis-rhinopneumonitis vaccine-tetanus toxoid" ;
    rdfs:subClassOf obo:VO_0002420, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10326
    ] .

obo:VO_0002429
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "equine EEV and WEV encephalomyelitis-rhinopneumonitis-influenza vaccine-tetanus toxoid" ;
    rdfs:subClassOf obo:VO_0002428, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0002430
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "equine EEV and WEV encephalomyelitis-rhinopneumonitis-influenza-West Nile Virus vaccine-tetanus toxoid" ;
    rdfs:subClassOf obo:VO_0002429, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0002431
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "horse EEV, VEV, WEV encephalomyelitis-West Nile Virus Vaccine-Tetanus Toxoid" ;
    rdfs:subClassOf obo:VO_0002401, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1485
    ] .

obo:VO_0002432
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Chlamydia Psittaci Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11768
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83554
    ] .

obo:VO_0002433
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Vaccine" ;
    rdfs:subClassOf obo:VO_0002440, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10786
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11768
    ] .

obo:VO_0002434
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Vaccine" ;
    rdfs:subClassOf obo:VO_0002433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83554
    ] .

obo:VO_0002435
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Chlamydia Psittaci Vaccine" ;
    rdfs:subClassOf obo:VO_0002440, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83554
    ] .

obo:VO_0002436
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia Vaccine" ;
    rdfs:subClassOf obo:VO_0002440, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10786
    ] .

obo:VO_0002437
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Vaccine" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83554
    ] .

obo:VO_0002438
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci-Rabies Vaccine" ;
    rdfs:subClassOf obo:VO_0002437, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0002439
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calici-Panleukopenia-Rabies Vaccine" ;
    rdfs:subClassOf obo:VO_0002436, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0002440
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Feline Rhinotracheitis-Calicivirus Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9685
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10334
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11978
    ] .

obo:VO_0002441
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis-Mareks Disease Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10390
    ] .

obo:VO_0002442
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Infectious Salmon Anemia Virus Vaccine-Aeromonas Salmonicida-Vibrio Anguillarum-Ordalii-Salmonicida Bacterin" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_117565
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_55987
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_641
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_645
    ] .

obo:VO_0002443
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox-Laryngotracheitis Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10261
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10261
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_10386
            ]
        )
    ] .

obo:VO_0002444
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox-Mareks Disease Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10261
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10390
    ] .

obo:VO_0002445
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Pox-Mycoplasma Gallisepticum Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10261
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2096
    ] .

obo:VO_0002446
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mannheimia Haemolytica-Pasteurella Multocida Vaccine" ;
    rdfs:subClassOf obo:VO_0001523, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0002447
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mareks Disease-Newcastle Disease Vaccine" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11176
    ] .

obo:VO_0002448
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "chicken Mareks disease-tenosynovitis vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10390
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38170
    ] .

obo:VO_0002449
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Vaccine-Clostridium Botulinum Type C Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002451, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ] .

obo:VO_0002450
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Vaccine-Clostridium Botulinum Type C-Pseudomonas Aeruginosa Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002449, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0002451
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Enteritis Vaccine-Clostridium Botulinum Type C Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10792
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0002452
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Enteritis Vaccine-Clostridium Botulinum Type C-Pseudomonas Aeruginosa Bacterin-Toxoid" ;
    rdfs:seeAlso "SNOMEDCT: 55262006; UMLS_CUI:C0310936" ;
    rdfs:subClassOf obo:VO_0002451, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0002453
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease-Bronchitis Vaccine-Salmonella Enteritidis Bacterin" ;
    rdfs:subClassOf obo:VO_0002457, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149539
    ] .

obo:VO_0002454
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Vaccine-Mycoplasma Gallisepticum Bacterin" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9031
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2096
    ] .

obo:VO_0002455
    obo:IAO_0000115 "A viral vaccine that protects against infection with Hirame rhabdovirus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Hirame rhabdovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38142
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38142
    ] .

obo:VO_0002456
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease-Fowl Pox Vaccine" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10261
    ] .

obo:VO_0002457
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Bronchitis Vaccine" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ] .

obo:VO_0002458
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Newcastle-Paramyxovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_260963
    ] .

obo:VO_0002459
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "bovine parainfluenza 3 vaccine-Leptospira Pomona vaccine" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11215
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_94063
    ] .

obo:VO_0002460
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002461 .

obo:VO_0002461
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-HardjoIcterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002462, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ] .

obo:VO_0002462
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002463 .

obo:VO_0002463
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Parvovirus Vaccine-Leptospira Canicola-Icterohaemorrhagiae vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0002464
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-CanicolaGrippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002465 .

obo:VO_0002465
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Parvovirus-Swine Influenza Vaccine-Erysipelothrix Rhusiopathiae-Leptospira CanicolaGrippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002461, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12845
    ] .

obo:VO_0002466
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus-Rabies Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0002408, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0002467
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Circovirus Vaccine- Mycoplasma Hyopneumoniae Bactin" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2099
    ] .

obo:VO_0002468
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Vaccine-Bordetella Bronchiseptica-Clostridium Perfringens Type C-Erysipelothrix Rhusiopathiae-Escherichia Coli-Pasteurella Multocida Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002469, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0002469
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002471, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11149
    ] .

obo:VO_0002470
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Vaccine-Escherichia Coli Bacterin" ;
    rdfs:subClassOf obo:VO_0002474, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11149
    ] .

obo:VO_0002471
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid" ;
    rdfs:subClassOf obo:VO_0002474, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1502
    ] .

obo:VO_0002472
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome-Circovirus Vaccine-Mycoplasma Hyopneumoniae Bacterin" ;
    rdfs:subClassOf obo:VO_0002467, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0002473
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome-Parvovirus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0001511, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0002474
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus Vaccine-Escherichia Coli Bacterin" ;
    rdfs:subClassOf obo:VO_0001495, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_562
    ] .

obo:VO_0002475
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Porcine Rotavirus-Transmissible Gastroenteritis Vaccine" ;
    rdfs:subClassOf obo:VO_0001495, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11149
    ] .

obo:VO_0002476
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Rabies Vaccine-Ehrlichia Risticii Bacterin" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_950
    ] .

obo:VO_0002477
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:NCBITaxon_12845
                obo:NCBITaxon_36420
            )
        ]
    ] .

obo:VO_0002478
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "Swine Influenza Vaccine-Erysipelothrix Rhusiopathiae Bacterin" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ] .

obo:VO_0002479
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Swine Influenza Vaccine-Erysipelothrix Rhusiopathiae-Mycoplasma Hyopneumoniae Bacterin" ;
    rdfs:subClassOf obo:VO_0002478, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2099
    ] .

obo:VO_0002480
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "Swine Influenza Vaccine-Mycoplasma Hyopneumoniae Bacterin" ;
    rdfs:seeAlso "USDA: 4995.22", "violinID:3028;3027" ;
    rdfs:subClassOf obo:VO_0002477, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2099
    ] .

obo:VO_0002481
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Trichomonas Foetus-Campylobacter Fetus-Leptospira vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_196
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_56690
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_171
                obo:NCBITaxon_196
                obo:NCBITaxon_56690
            )
        ]
    ] .

obo:VO_0002482
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Coronavirus-Parvovirus Vaccine" ;
    rdfs:subClassOf obo:VO_0002393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ] .

obo:VO_0002483
    obo:IAO_0000115 "A horse vaccine that protects against EEE, VEE, WEE, influenza virius infection, and West Nile virus infection. " ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "horse Encephalomyelitis-Influenza-West Nile Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11039
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0002484
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Mink Distemper-Enteritis Vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10792
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ] .

obo:VO_0002485
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "porcine parvovirus-erysipelothrix rhusiopathiae vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9823
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10796
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ] .

obo:VO_0002486
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Virus Diarrhea-Respiratory Syncytial Virus Vaccine" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0002487
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract" ;
    rdfs:subClassOf obo:VO_0002403, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9612
    ] .

obo:VO_0002488
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Vaccine-Leptospira Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002352, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11215
    ] .

obo:VO_0002489
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus Virus Vaccine-Haemophilus somnus Bacterin" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_731
    ] .

obo:VO_0002490
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Vaccine-Haemophilus somnus-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin" ;
    rdfs:subClassOf obo:VO_0002354, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_196
    ] .

obo:VO_0002491
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Adenovirus Type 2-Parainfluenza-Bordetella Bronchiseptica Modified Live Virus & Avirulent Live Culture Vaccine (USDA: 12X1.21)" ;
    rdfs:seeAlso "USDA: 12X1.21" ;
    rdfs:subClassOf obo:VO_0002386, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002492
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.20)" ;
    rdfs:seeAlso "USDA: 46L9.20" ;
    rdfs:subClassOf obo:VO_0002404, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002493
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "Fowl Laryngotracheitis-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16J1.R3)" ;
    rdfs:seeAlso "USDA: 16J1.R3" ;
    rdfs:subClassOf obo:VO_0002441, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0002494
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:comment """created according to 
WHO Technical Report Series, No. 927, 2005
Annex 3
Recommendations for the production and control of influenza vaccine (inactivated)""" ;
    rdfs:label "influenza vaccine (whole virion, inactivated)" ;
    rdfs:subClassOf obo:VO_0001176 .

obo:VO_0002495
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:comment """created according to 
WHO Technical Report Series, No. 927, 2005
Annex 3
Recommendations for the production and control of influenza vaccine (inactivated)""" ;
    rdfs:label "influenza vaccine (split virion, inactivated)" ;
    rdfs:subClassOf obo:VO_0001176 .

obo:VO_0002496
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:comment """created according to 
WHO Technical Report Series, No. 927, 2005
Annex 3
Recommendations for the production and control of influenza vaccine (inactivated)""" ;
    rdfs:label "influenza vaccine (surface antigens, inactivated)" ;
    rdfs:subClassOf obo:VO_0001176 .

obo:VO_0002497
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:comment """created according to 
WHO Technical Report Series, No. 927, 2005
Annex 3
Recommendations for the production and control of influenza vaccine (inactivated)""" ;
    rdfs:label "influenza vaccine (inactivated, adjuvanted)" ;
    rdfs:subClassOf obo:VO_0001176 .

obo:VO_0002498
    dc:creator "YL" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:comment """GSK Acquires Influenza Vaccine Manufacturer ID Biomedical Corporation
http://www.medicalnewstoday.com/releases/34803.php

GlaxoSmithKline plc (NYSE:GSK) announced the completion of the acquisition of ID Biomedical. This follows regulatory clearances of the transaction and adoption of the acquisition agreement by ID Biomedical's shareholders (which occurred on the 16th of November). ID Biomedical becomes a wholly-owned subsidiary of GSK. ..."""@en ;
    rdfs:label "ID Biomedical Corporation of Quebec" .

obo:VO_0002499
    a owl:Class ;
    rdfs:label "Influenza A (H1N1) 2009 Monovalent Vaccine (IDB)" ;
    rdfs:subClassOf obo:VO_0003211, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0002498 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:VO_0000908
    ] .

obo:VO_0002500
    obo:IAO_0000115 "A vaccine that protects against Listeria monocytogenes." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Listeria monocytogenes vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1639
    ] .

obo:VO_0002501
    obo:IAO_0000115 "A vaccine that protects against Mycobacterium avium." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Mycobacterium avium vaccine"@en ;
    rdfs:subClassOf obo:VO_0000592, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1764
    ] .

obo:VO_0002502
    obo:IAO_0000115 "A bacterial vaccine that protects against infection with Staphylococcus aureus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Staphylococcus aureus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000770, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0002503
    obo:IAO_0000115 "A bacterial gene that is from Streptococcus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "'Streptococcus gene'"@en ;
    rdfs:subClassOf obo:OGG_2000000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_1279
    ] .

obo:VO_0002504
    obo:IAO_0000115 "A bacterial gene that is from Streptococcus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Streptococcus equi gene"@en ;
    rdfs:subClassOf obo:VO_0002503, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_1336
    ] .

obo:VO_0002505
    obo:IAO_0000115 "A Aeromonas vaccine that protects against Aeromonas hydrophila.", "An Aeromonas vaccine that protects against Aeromonas hydrophila." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Aeromonas hydrophila vaccine"@en ;
    rdfs:subClassOf obo:VO_0000589, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_644
    ] .

obo:VO_0002506
    obo:IAO_0000115 "An Edwardsiella bacterial vaccine that protects against Edwardsiella tarda." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Edwardsiella tarda vaccine"@en ;
    rdfs:subClassOf obo:VO_0000602, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_636
    ] .

obo:VO_0002507
    obo:IAO_0000115 "A bacterial vaccine that protects against infections by  Salmonella typhimurium species." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Salmonella typhimurium vaccine"@en ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_90371
    ] .

obo:VO_0002508
    obo:IAO_0000115 "A bacterial vaccine that protects against infections by  Salmonella enterica subsp. enterica serovar Gallinarum." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Salmonella gallinarum vaccine"@en ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_594
    ] .

obo:VO_0002509
    obo:IAO_0000115 "A bacterial vaccine that protects against infections by Salmonella enterica subsp. enterica serovar Enteritidis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Salmonella enteritidis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149539
    ] .

obo:VO_0002510
    obo:IAO_0000115 "A bacterial vaccine that protects against infections by Yersinia pseudotuberculosis." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Yersinia pseudotuberculosis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000601, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_633
    ] .

obo:VO_0002511
    obo:IAO_0000115 "A viral vaccine that protects against infection of Human metapneumovirus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Human metapneumovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_162145
    ] .

obo:VO_0002512
    obo:IAO_0000115 "A viral vaccine that protects against infection of Human respiratory syncytial virus." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Human respiratory syncytial virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11250
    ] .

obo:VO_0002513
    obo:IAO_0000115 "a malaria vaccine that protects against malaria caused by Plasmodium berghei." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Plasmodium berghei vaccine"@en ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5821
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5821
    ] .

obo:VO_0002514
    obo:IAO_0000115 "a malaria vaccine that protects against malaria caused by Plasmodium yoelii." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Plasmodium yoelii vaccine"@en ;
    rdfs:subClassOf obo:VO_0000761 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000761
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_5861
            ]
        )
    ] .

obo:VO_0002515
    obo:IAO_0000115 "A protozoan gene that is from Leishmania infantum." ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "Leishmania infantum gene"@en ;
    rdfs:subClassOf obo:VO_0000174, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:NCBITaxon_5671
    ] .

obo:VO_0002516
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "The mutant strain, with deletion of apxIA gene, obtained in this study offered a level of cross-serovar protection against A. pleuropneumoniae infection in mice and pigs (Reference: PMID: 16930871)." ;
    rdfs:label "apxIA from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4850247; PMID: 16930871" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002517
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In the intra-peritoneal mouse model, the virulence of the mutant strain decreased at least 100 fold compared with the parent strain. The mutant was evaluated as a potential vaccine using a vaccination-challenge trial. The death number and lung lesion score in the vaccinated pigs given the serovar 1 challenge were obviously lower than those in the unvaccinated pigs" ;
    rdfs:label "apxIC from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Protein_ID: 1477456; PMID: 18062275" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002518
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion in ureC and apxIIA genes of Actinobacillus pleuropneumoniae serotype 2 prototype provides attenuation and protection in pigs against challenge with the virulent parent strain of A. pleuropneumoniae" ;
    rdfs:label "apxIIA from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Protein_ID: 255959000; PMID: 12438394" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002519
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In the present study, the gene encoding the ApxII-activating protein, apxIIC, was insertionally inactivated on the chromosome of a serovar 7 strain, HS93. Pigs vaccinated with live HS93C-Ampr via the intranasal route were protected against a cross-serovar challenge with a virulent serovar 1 strain of A. pleuropneumoniae" ;
    rdfs:label "apxIIC from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Protein_ID: 52630373; PMID: 10085043" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002520
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In the present study, the gene encoding the ApxII-activating protein, apxIIC, was insertionally inactivated on the chromosome of a serovar 7 strain, HS93. Pigs vaccinated with live HS93C-Ampr via the intranasal route were protected against a cross-serovar challenge with a virulent serovar 1 strain of A. pleuropneumoniae" ;
    rdfs:label "apxIIC from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Protein_ID: 52630373; PMID: 10085043" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002521
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An apxIIIB mutant, in combination with an apxIIID mutation, is highly attenuated in pigs and induces significant protection from challenge with wild type A. pleuropneumoniae. The mutant also was slightly attenuated in mice and induced protection in mice against challenge from the parent strain" ;
    rdfs:label "apxIIIB from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Nucleotide_ID: 470686; PMID: 19887737" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002522
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An apxIIID mutant, in combination with an apxIIIB mutation, is highly attenuated in pigs and induces significant protection from challenge with wild type A. pleuropneumoniae. The mutant also was slightly attenuated in mice and induced protection in mice against challenge from the parent strain" ;
    rdfs:label "apxIIID from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Nucleotide_ID: 470687; PMID: 19887737" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002523
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A precisely defined DeltaapxIICDeltaapxIVA double-deletion mutant of A. pleuropneumoniae was constructed based on HB04C(-) by transconjugation and counterselection. The results demonstrated that the DeltaapxIICDeltaapxIVA double mutant strain was less virulent than HB04C(-). Despite attenuation of virulence, the DeltaapxIICDeltaapxIVA double mutant remains immunogenic and conferred a similar level of protective immunity to pigs against challenge with a lethal dose of a heterologous fully virulent standard serovar 1 strain of A. pleuropneumoniae" ;
    rdfs:label "apxIVA from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Protein_ID: 6671152; PMID: 17767980" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002524
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection. The double-mutant contains no foreign DNA, is highly attenuated, protects pigs from homologous challenge upon a single aerosol application" ;
    rdfs:label "ureC from Actinobacillus pleuropneumoniae" ;
    rdfs:seeAlso "NCBI_Protein_ID: 303253439; PMID: 12438394" ;
    rdfs:subClassOf obo:VO_0001384, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002525
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An mntA deletion mutant, generated by allelic replacement, in Bacillus anthracis was attenuated and provided protection for guinea pigs against lethal spore dose (60 LD50) of the virulent B. anthracis Vollum strain" ;
    rdfs:label "mntA from Bacillus anthracis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 7848141; PMID:  16194238" ;
    rdfs:subClassOf obo:VO_0001402, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002526
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An actA mutant is attenuated in mice and induced significant protection from challenge with wild type L. monocytogenes" ;
    rdfs:label "actA from Listeria monocytogenes" ;
    rdfs:seeAlso "NCBI_Gene_ID: 987035; PMID: 12763691" ;
    rdfs:subClassOf obo:VO_0001403, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002527
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An actA mutant is attenuated in mice and induced significant protection from challenge with wild type L. monocytogenes" ;
    rdfs:label "actA from Listeria monocytogenes" ;
    rdfs:seeAlso "NCBI_Gene_ID: 987035; PMID: 12763691" ;
    rdfs:subClassOf obo:VO_0001403, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002528
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A plcB mutant, in combination with an actA mutant, is attenuated in mice and induces significant protection from challenge with wild type L. monocytogenes" ;
    rdfs:label "plcB from Listeria monocytogenes" ;
    rdfs:seeAlso "NCBI_Gene_ID: 987036; PMID: 12763691" ;
    rdfs:subClassOf obo:VO_0001403, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002529
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A M. avium relA mutant is attenuated in calves and goats. This mutant also elicited an immune response in goats that limited colonization by challenge wild type M. avium" ;
    rdfs:label "relA from Mycobacterium avium" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2717869; PMID:  21565243" ;
    rdfs:subClassOf obo:VO_0001404, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002530
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A drrC mutant is highly attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "drrC from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 888491; PMID: 14702160" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002531
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An fadD26 mutant is attenuated in mice and induced significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "fadD26 from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 887603; PMID: 15958066" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002532
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of leuD gene was shown to be highly attenuated. Immunocompetent BALB/c mice vaccinated with the DleuD auxotroph were protected as well as BCG in terms of survival following an intravenous or aerosol challenge with virulent M. tuberculosis" ;
    rdfs:label "leuD from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 888225; PMID: 10768986" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002533
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A lysA mutant, in combination with a secA2 mutation, is highly attenuated in mice and induced significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "lysA from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 886960; PMID:  21264335" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002534
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A Mce-2 mutant in Mycobacterium tuberculosis is attenuated and provides protection against challenge for mice" ;
    rdfs:label "mce-2 from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 925014; PMID: 16388878" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002535
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mce-3 mutant in Mycobacterium tuberculosis is attenuated and provides protection against challenge for mice" ;
    rdfs:label "mce-3 from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 923491; PMID: 16388878" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002536
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A panCD mutant is attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "panC from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 885459; PMID: 12219086" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002537
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A panCD mutant is attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "panC from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 885459; PMID: 12219086" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002538
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A panCD mutant is attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "panD from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 885596; PMID: 12219086" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002539
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A panCD mutant is attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "panD from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 885596; PMID: 12219086" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002540
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Study evaluated immunogenicity and protection against Mycobacterium tuberculosis in rhesus monkeys with an attenuated M. tuberculosis with a disrupted phoP gene (SO2) as a single-dose vaccine. SO2 treatment showed reduced average lung bacterial counts (1.0 and 1.2 log respectively, compared with 0.4 log for BCG) and significant protective effect by reduction in C-reactive protein levels, body weight loss, and decrease of erythrocyte-associated hematologic parameters (MCV, MCH, Hb, Ht) as markers of inflammatory infection, all relative to non-vaccinated controls" ;
    rdfs:label "phoP from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 888772; PMID: 19367339" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002541
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A proC mutant is highly attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis that is equal to the protection induced by the current vaccine BCG" ;
    rdfs:label "proC from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 887256; PMID: 11160012" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002542
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "RD1 and panCD mutants in Mycobacterium tuberculosis were attenuated and provided protection in CD4-deficient mice against an aerosol challenge with virulent M. tuberculosis" ;
    rdfs:label "RD1 from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 885777; PMID: 16860907" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002543
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Vaccination of mice and guinea pigs with a secA2 mutant significantly increased resistance to M. tuberculosis challenge compared with standard M. bovis bacille Calmette-Guérin vaccination" ;
    rdfs:label "secA2 from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 885594; PMID: 17671656" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002544
    obo:IAO_0000115 "A viral vaccine that protects against infection with Reticuloendotheliosis virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Reticuloendotheliosis virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11636
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11636
    ] .

obo:VO_0002545
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A sigE mutant is highly attenuated in mice and induced significant protection from challenge with wild type M. tuberculosis, more so than the existing vaccine BCG" ;
    rdfs:label "sigE from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 888751; PMID:  20457786" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002546
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A trpD mutant is highly attenuated in mice and induces more protection from challenge with wild type M. tuberculosis than that induced by the current vaccine BCG" ;
    rdfs:label "trpD from Mycobacterium tuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 887681; PMID:  11160012" ;
    rdfs:subClassOf obo:VO_0000164, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002547
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is attenuated in mice and induced significant protection from challenge with wild type S. aureus" ;
    rdfs:label "aroA from Staphylococcus aureus" ;
    rdfs:seeAlso "NCBI_Gene_ID:  8614197; PMID: 16714581" ;
    rdfs:subClassOf obo:VO_0001405, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002548
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A vicK mutant is attenuated in mice and induced protection from challenge with wild type S. equi" ;
    rdfs:label "vicK from Streptococcus equi" ;
    rdfs:seeAlso "NCBI_Gene_ID: 6760966; PMID: 19088917" ;
    rdfs:subClassOf obo:VO_0002504, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002549
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An A. hydrophila aroA mutant is highly attenuated in trout, and a single immunization conferred significant protection from challenge with wild type A. hydrophila" ;
    rdfs:label "aroA from Aeromonas hydrophila" ;
    rdfs:seeAlso "NCBI_Gene_ID:  4489425; PMID: 9573055" ;
    rdfs:subClassOf obo:VO_0001406, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002550
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "The aroA gene was inactivated by inserting a fragment expressing kanamycin resistance within the coding sequence and challenged in fish. The LD50 for unvaccinated fish was 71. In contrast, the LD50 was 1.8 x 104 in fish vaccinated once and 3 x 105 in fish vaccinated twice" ;
    rdfs:label "aroA from Aeromonas salmonicida" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4997369; PMID: 8478107" ;
    rdfs:subClassOf obo:VO_0001408, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002551
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of the aroA gene highly attenuates B. bronchiseptica, severely impairing its ability to colonize and survive in the respiratory tract of mice. Upon challenge with wild type B. bronchiseptica, the mice immunised with live attenuated B. bronchiseptica aroA mutant had rapidly reduced numbers of B. bronchiseptica in their respiratory tract" ;
    rdfs:label "aroA from Bordetella bronchiseptica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2659145; PMID: 12009288" ;
    rdfs:subClassOf obo:VO_0001407, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002552
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of the aroA gene highly attenuates B. bronchiseptica, severely impairing its ability to colonize and survive in the respiratory tract of mice. Upon challenge with wild type B. bronchiseptica, the mice immunised with live attenuated B. bronchiseptica aroA mutant had rapidly reduced numbers of B. bronchiseptica in their respiratory tract" ;
    rdfs:label "aroA from Bordetella bronchiseptica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2659145; PMID: 12009288" ;
    rdfs:subClassOf obo:VO_0001407, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002553
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A double mutant strain of Bordetella Bronchiseptica lacking adenylate cyclase(cyaA gene) and type III secretion(bscN gene) is attenuated and provides protection in mice against 5 × 105 CFU of RB50, the B. Bronchiseptica parent strain" ;
    rdfs:label "bscN from Bordetella bronchiseptica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2662485; PMID:  17452472" ;
    rdfs:subClassOf obo:VO_0001407, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002554
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A double mutant strain of Bordetella Bronchiseptica lacking adenylate cyclase(cyaA gene) and type III secretion(bscN gene) is attenuated and provides protection in mice against 5 × 105 CFU of RB50, the B. Bronchiseptica parent strain" ;
    rdfs:label "cyaA from Bordetella bronchiseptica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2661688; PMID: 17452472" ;
    rdfs:subClassOf obo:VO_0001407, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002555
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A dnt mutant in Bordetella bronchiseptica was attenuated and provides protection in guinea pigs against intranasal challenge with strain L3" ;
    rdfs:label "dnt from Bordetella bronchiseptica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2661538; PMID:  3182989" ;
    rdfs:subClassOf obo:VO_0001407, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002556
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A trpE mutant, in combination with an aroA mutation, is attenuated in mice and induces significant protection from challenge with wild type B. bronchiseptica" ;
    rdfs:label "trpE from Bordetella bronchiseptica" ;
    rdfs:seeAlso "NCBI_Protein_ID: 8515760; PMID: 12694904" ;
    rdfs:subClassOf obo:VO_0001407, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002557
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in mice and induces significant protection from challenge with wild type B. pertussis" ;
    rdfs:label "aroA from Bordetella pertussis" ;
    rdfs:seeAlso "NCBI_Protein_ID: 144037; PMID: 2407655" ;
    rdfs:subClassOf obo:VO_0001409, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002558
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A live attenuated B. pertussis vaccine strain BPZE1, developed by deleting dnt gene, protects mice upon a single intranasal administration" ;
    rdfs:label "dnt from Bordetella pertussis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2666936; PMID:  18762220" ;
    rdfs:subClassOf obo:VO_0001409, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002559
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A flagella-less mutant of Borrelia burgdorferi (HB19Fla-) was attenuated in immunodeficient SCID mice. Mice were challenged 28 days later with virulent strain Sh. 2 and were protected from challenge" ;
    rdfs:label "fla from Borrelia burgdorferi" ;
    rdfs:seeAlso "NCBI_Protein_ID: 435009; PMID: 8627071" ;
    rdfs:subClassOf obo:VO_0001410, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002560
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A asp24 mutation in Brucella abortus is attenuated and provides significant protection in mice" ;
    rdfs:label "asp24 from B. abortus" ;
    rdfs:seeAlso "NCBI_Protein_ID:  2353000; PMID: 17664263" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002561
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A bp26 mutant in Brucella melitensis was attenuated and provided protection against challenge in mice" ;
    rdfs:label "bp26 from B. melitensis" ;
    rdfs:seeAlso "NCBI_Protein_ID: 265991532; PMID: 15246618" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002562
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Brucella DeltaexsA mutant showed decreased survival in mice compared to the survival of parental strain S2308. This demonstrated that ExsA is critical for full bacterial virulence. The B. abortus exsA deletion mutant was used as a live vaccine candidate. Challenge experiments revealed that the exsA mutant strain induced superior protective immunity in BALB/c mice compared to the protective immunity induced by strain S19 or RB51" ;
    rdfs:label "exsA from B. abortus" ;
    rdfs:seeAlso "NCBI_Gene_ID:  3787220; PMID: 12183550" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002563
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Unmarked rough B. abortus and B. melitensis deletion mutants of manBA (including manA and manB) were attenuated. These mutants provided protection against virulent Brucella challenge in mice" ;
    rdfs:label "manA from B. melitensis" ;
    rdfs:seeAlso "NCBI_Protein_ID: 260563601; PMID: 16790778" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002564
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mutants manB and manA were attenuated in Brucella melitensis and provided protection against challenge in mice's livers" ;
    rdfs:label "manB from B. melitensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1198671; PMID:  17664263" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002565
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mucR mutant has a significantly reduced degree of colonization in mice and protects against wild type B. melitensis 16M" ;
    rdfs:label "mucR from B. melitensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1197075; PMID:  21708998" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002566
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A omp25 mutant is attenuated and provides protection against challenge in mice" ;
    rdfs:label "omp25 from B. melitensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1196960; PMID: 12151196" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002567
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A omp31 mutant in Brucella melitensis was attenuated and provided protection against challenge in mice" ;
    rdfs:label "omp31 from B. melitensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 7676420; PMID: 15246618" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002568
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A pgk mutant is attenuated in mice and induces significant protection from challenge with wild type B. abortus" ;
    rdfs:label "pgk from B. abortus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3788256; PMID:  20194591" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002569
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A pgm mutant is attenuated in mice and induces significant protection from challenge with wild type B. abortus" ;
    rdfs:label "pgm from B. abortus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3788847; PMID: 14573645" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002570
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mice infected with delta purE201 developed only five to eight times normal spleen weight at 1 week p.i. and produced no interleukin-6 in their serum, which is much lower than the mice infected with the parental strain (16M)" ;
    rdfs:label "purE from B. melitensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1196006; PMID: 8675325" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002571
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A purE/purK mutant of B. melitensis 16M was attenuated in mice when given intraperitoneally. Nine weeks after immunization, mice were protected from challenge with wild type B. melitensis" ;
    rdfs:label "purK from B. melitensis" ;
    rdfs:seeAlso "NCBI_Protein_ID: 20141763; PMID: 7642258" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002572
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virB2 mutant is attenuated in Brucella melitensis and provides protection in mice" ;
    rdfs:label "virB2 from B. abortus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3827981; PMID: 17664263" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002573
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "The deletion of vjbR gene in Brucella melitensis strain 16M made a live attenuated vaccine and provided significance protection against mice" ;
    rdfs:label "vjbR from B. melitensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1198888; PMID: 21530111" ;
    rdfs:subClassOf obo:VO_0001400, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002574
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of gene znuA attenuates Brucella abortus and this live attenuated vaccine was challenged in mice. These mice showed significantly fewer spenic CFU" ;
    rdfs:label "znuA from Brucella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 3827700; PMID: 16790759" ;
    rdfs:subClassOf obo:VO_0000793, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002575
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "The aroC deletion in the resultant mutant, designated A2ΔaroC, was confirmed by PCR, Southern hybridization and failure of the mutant to grow in a defined medium without aromatic compounds. The constructed unmarked aroC mutant of B. pseudomallei is attenuated in both BALB/c and C57Bl/6 mice and is able to confer significant protection in C57Bl/6 mice" ;
    rdfs:label "aroC from Burkholderia pseudomallei" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4899749; PMID: 19323044" ;
    rdfs:subClassOf obo:VO_0001411, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002576
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An asd mutant is highly attenuated in mice. This mutant was also able to protect against acute inhalation melioidosis caused by challenge with wild type B. pseudomallei" ;
    rdfs:label "asd from Burkholderia pseudomallei" ;
    rdfs:seeAlso "NCBI_Protein_ID: 2358232; PMID:  21807903" ;
    rdfs:subClassOf obo:VO_0001411, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002577
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mice that were challenged with a higher dose of mutant 56:65 purM were protected" ;
    rdfs:label "purM from Burkholderia pseudomallei" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3092877; PMID: 19121696" ;
    rdfs:subClassOf obo:VO_0001411, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002578
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Although 30:93a purN -immunized mice were challenged with a 10-fold higher dose of WT E8, mice were strongly protected and showed no signs of clinical illness until the experiment was terminated" ;
    rdfs:label "purN from Burkholderia pseudomallei" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3092878; PMID: 19121696" ;
    rdfs:subClassOf obo:VO_0001411, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002579
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A crp mutant is attenuated in zebrafish and catfish that were immunized intramuscularly and intracoelomically, respectively. Six weeks after immunization, both zebrafish and catfish were protected from challenge with wild type E. ictaluri" ;
    rdfs:label "crp from Edwardsiella ictaluri" ;
    rdfs:seeAlso "NCBI_Gene_ID: 7962173; PMID: 22015784" ;
    rdfs:subClassOf obo:VO_0001412, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002580
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC mutant is attenuated in zebra fish. The aroC mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 68.3%" ;
    rdfs:label "aroC from Edwardsiella tarda" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8608790; PMID: 21777261" ;
    rdfs:subClassOf obo:VO_0001413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002581
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC mutant is attenuated in zebra fish. The aroC mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 68.3%" ;
    rdfs:label "aroC from Edwardsiella tarda" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8608790; PMID: 21777261" ;
    rdfs:subClassOf obo:VO_0001413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002582
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC mutant is attenuated in zebra fish. The aroC mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 68.3%" ;
    rdfs:label "aroC from Edwardsiella tarda" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8608790; PMID: 21777261" ;
    rdfs:subClassOf obo:VO_0001413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002583
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An esrB mutant is highly attenuated in fish (turbot), with an LD50 of 10(8.1)cfu/fish. Vaccination with this mutant elicited significant protection from wild type E. tarda" ;
    rdfs:label "esrB from Edwardsiella tarda" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8607237; PMID: 17478097" ;
    rdfs:subClassOf obo:VO_0001413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002584
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC and esrC mutant is attenuated in zebra fish. This mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 71.3%" ;
    rdfs:label "esrC from Edwardsiella tarda" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8607212; PMID: 21777261" ;
    rdfs:subClassOf obo:VO_0001413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002585
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC and slyA mutant is attenuated in zebra fish. This mutant is also protective against challenge from wild type E. tarda, resulting in a relative percent survival of 80.1%" ;
    rdfs:label "slyA from Edwardsiella tarda" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8608031; PMID: 21777261" ;
    rdfs:subClassOf obo:VO_0001413, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002586
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A carAB mutant is attenuated in turkeys and induces significant protection from challenge with wild type E. coli" ;
    rdfs:label "carA from Escherichia coli" ;
    rdfs:seeAlso "NCBI_Gene_ID: 949025; PMID: 8063392" ;
    rdfs:subClassOf obo:VO_0000161, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002587
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A carAB mutant is attenuated in turkeys and induces significant protection from challenge with wild type E. coli" ;
    rdfs:label "carB from Escherichia coli" ;
    rdfs:seeAlso "NCBI_Gene_ID: 944775; PMID: 8063392" ;
    rdfs:subClassOf obo:VO_0000161, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002588
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ler deletion mutant derived from wild-type EHEC O157:H7 86-24 was constructed by use of suicide vector pCVD442. Following challenge of 7-day-old suckling mice with O157:H7 EDL933, 75.2% born to group B mothers (immunized with F25) sur- vived, as did 83.0% born to group C mothers (immunized with F105). The surviving suckling mice consistently gained body weight. Only 16.8% of sucking mice born to control group mice survived the challenge" ;
    rdfs:label "ler from Escherichia coli" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8219269; PMID: 19682616" ;
    rdfs:subClassOf obo:VO_0000161, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002589
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of waaL results in a strain that stimulates enhanced urothelial cytokine secretion, which is an enhanced innate immune response. Inoculation with the vaccine strain protected mice against challenge with a broad range of clinical uropathogenic E. coli isolates and produced immunity that lasted ⩾8 weeks" ;
    rdfs:label "rfaL from Escherichia coli" ;
    rdfs:seeAlso "NCBI_Gene_ID: 948148; PMID: 19522648" ;
    rdfs:subClassOf obo:VO_0000161, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002590
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "There was a deletion in gene capB of F. tularensis live vaccine strain. LVS capB, while much less virulent than LVS, induces potent protective immunity against lethal LVS i.n. challenge in mice, comparable to that induced by LVS" ;
    rdfs:label "capB from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3952402; PMID:  20643859" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002591
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A clpB mutant in Francisella tularensis subspecies tularensis strain SCHU S4 was attenuated and provided protection against aerosol challenge in mice" ;
    rdfs:label "clpB from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3192509; PMID: 20018266" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002592
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A FTL0552 mutant in Francisella tularensis was attenuated and provided partial protection in mice against challenge with a lethal dose of the virulent SchuS4 strain when compared to naive mice" ;
    rdfs:label "FTL0552 from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3952730; PMID: 18613792]" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002593
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An FTT0918 mutant showed significantly reduced virulence in mice. Mice that recovered from infection with the mutant were protected 2 months later from challenge with wild type F. tularensis" ;
    rdfs:label "FTT0918 from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3191684; PMID: 16299332" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002594
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A galU mutant is attenuated in mice, with only transient weight loss observed. Two months after inoculation, mice were challenge with wild type F. tularensis and were protected, once again only experiencing transient weight loss" ;
    rdfs:label "galU from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3191600; PMID: 21819572" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002595
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaA mutant is highly attenuated in mice and induces significant protection from challenge with parent strain F. tularensis LVS" ;
    rdfs:label "guaA from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3951701; PMID: 19368784" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002596
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaB mutant is attenuated in mice and induces significant protection from challenge with parent strain F. tularensis LVS" ;
    rdfs:label "guaB from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3952496; PMID: 19368784" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002597
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Intranasal vaccination with KKF235 (F. tularensis subsp. novicida mutant (DeltaiglB) ) protected mice from subsequent homotypic challenge with U112 as well as heterotypic challenge with F. tularensis subsp. holarctica (LVS). Most significantly, oral immunization with KKF235 protected mice from a highly lethal subsp. tularensis (SCHU S4) pulmonary challenge" ;
    rdfs:label "iglB from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4548125; PMID: 20016043" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002598
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An iglC mutant is highly attenuated in mice. Inoculated mice were challenged 30 days later with wild type F. tularensis and were highly protected" ;
    rdfs:label "iglC from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4548124; PMID: 16552035" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002599
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A purMCD mutant in Francisela tularensis was attenuated. A low dosage of F. tularensis LVS delta purMCD mutant provided protection against challenge in mice" ;
    rdfs:label "purC/purD from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3952576; PMID:  16861631" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002600
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mice, which had been immunized with at least 6.95×103 cfu of F. tularensis U112 purF::Cm, were protected against the subsequent F. tularensis subspecies novicida challenge" ;
    rdfs:label "purF from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4548578; PMID: 16930871" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002601
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A purMCD mutant in Francisella tularensis was attenuated. A low dose of the F. tularensis LVS delta purMCD mutant provided protection against subsequent lethal challenge with the LVS parental strain" ;
    rdfs:label "purM from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3952575; PMID:  16861631" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002602
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice were vaccinated intranasally (i.n.) with the sodB(Ft) mutant and challenged i.n. with lethal doses of F. tularensis SchuS4. SodB(Ft) vaccinated mice following SchuS4 challenge exhibited significantly reduced bacterial burden in lungs, liver and spleen, regulated production of pro-inflammatory cytokines and less severe histopathological lesions compared to the LVS vaccinated mice. The sodB(Ft) vaccination induced a potent humoral immune response and protection against SchuS4 required both CD4 and CD8 T cells in the vaccinated mice" ;
    rdfs:label "sodB from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4548021; PMID: 18692537" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002603
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A sodC mutant in Francisella tularensis subspecies holarctica was attenuated and provided protection and cleared the infection against lethal challenge in nearly 50% of the mice infected with the ΔsodC mutant" ;
    rdfs:label "sodC from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Protein_ID: 1314283; PMID: 19684141" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002604
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A wbtA mutant in Francisella tularensis was attenuated and provided protection in mice against challenge with an otherwise lethal dose of either F. tularensis LVS or a fully virulent clinical isolate of F. tularensis type B" ;
    rdfs:label "wbtA from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3191939; PMID: 17296751" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002605
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A wbtI mutant is attenuated in mice. The mutant protected against a low dose challenge with the parental strain, but was less effective against higher doses. However, increasing the immunization dose increased the resistance to higher challenge doses" ;
    rdfs:label "wbtI from Francisella tularensis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 5522688; PMID: 17768257" ;
    rdfs:subClassOf obo:VO_0001414, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002606
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in mice and induced significant protection after two doses from challenge with wild type M. haemolytica" ;
    rdfs:label "aroA from Mannheimia haemolytica" ;
    rdfs:seeAlso "NCBI_Protein_ID: 451485; PMID: 7839583" ;
    rdfs:subClassOf obo:VO_0001415, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002607
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lpd mutant is highly attenuated in chickens and induces significant protection from challenge with wild type M. gallisepticum" ;
    rdfs:label "lpd from Mycoplasma gallisepticum" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1089767; PMID: 18342996" ;
    rdfs:subClassOf obo:VO_0001416, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002608
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A metH mutant, in combination with a siaD mutation, is attenuated in mice and induces significant protection from challenge with wild type N. meningitidis" ;
    rdfs:label "metH from Neisseria meningitidis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 903064; PMID:  14688114" ;
    rdfs:subClassOf obo:VO_0001417, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002609
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An rfaF mutant, in combination with a siaD mutation, is attenuated in mice and induces significant protection from challenge with wild type N. meningitidis" ;
    rdfs:label "rfaF from Neisseria meningitidis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 904029; PMID:  14688114" ;
    rdfs:subClassOf obo:VO_0001417, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002610
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A siaD mutant, in combination with either a metH or rfaF mutation, is attenuated in mice and induces protection from challenge with wild type N. meningitidis" ;
    rdfs:label "siaD from Neisseria meningitidis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 903210; PMID:  14688114" ;
    rdfs:subClassOf obo:VO_0001417, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002611
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A siaD mutant, in combination with either a metH or rfaF mutation, is attenuated in mice and induces protection from challenge with wild type N. meningitidis" ;
    rdfs:label "siaD from Neisseria meningitidis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 903210; PMID:  14688114" ;
    rdfs:subClassOf obo:VO_0001417, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002612
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in calves and induces significant protection from challenge with wild type P. multocida" ;
    rdfs:label "aroA from Pasteurella multocida" ;
    rdfs:seeAlso "NCBI_Protein_ID: 581456; PMID: 17875632" ;
    rdfs:subClassOf obo:VO_0001418, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002613
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is attenuated in mice and induced significant protection from challenge with wild type S. typhi Ty2" ;
    rdfs:label "aroA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1068996; PMID: 3039297" ;
    rdfs:subClassOf obo:VO_0001419, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002614
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of AroC results in attenuation in humans, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain \"CVD 908\"" ;
    rdfs:label "aroC from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1069415; PMID: 17582563" ;
    rdfs:subClassOf obo:VO_0001419, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002615
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of AroC results in attenuation in humans, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain \"CVD 908\"" ;
    rdfs:label "aroC from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1069415; PMID: 17582563" ;
    rdfs:subClassOf obo:VO_0001419, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002616
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of AroD results in attenuation in humans, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain \"CVD 908\"" ;
    rdfs:label "aroD from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1070649; PMID: 17582563" ;
    rdfs:subClassOf obo:VO_0001419, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002617
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An asd mutant, alone or in combination with a rfc mutation, is attenuated in mice and induces significant protection from challenge with wild type Salmonella typhimurium" ;
    rdfs:label "asd from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 267995764; PMID:  20799091" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002618
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An asd mutant, alone or in combination with a rfc mutation, is attenuated in mice and induces significant protection from challenge with wild type Salmonella typhimurium" ;
    rdfs:label "asd from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 267995764; PMID:  20799091" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002619
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An atpA mutant is attenuated in mice and induces significant protection from challenge with wild type S. typhimurium" ;
    rdfs:label "atpA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 301160399; PMID: 19649318" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002620
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cbiA mutant, in combination with a cobS mutation, is attenuated in chickens and induces significant protection from challenge with wild type S. Gallinarum. This mutant was also able to provide some protection against S. Enteritidis" ;
    rdfs:label "cbiA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6923268; PMID: 20153354" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002621
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1941) is attenuated in mice after oral immunization. This mutant is also protective, and had a vaccine efficacy of 76% against challenge with wild type Salmonella Enteritidis" ;
    rdfs:label "clpP from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6950532; PMID: 21807911" ;
    rdfs:subClassOf obo:VO_0001422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002622
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in clpP (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice, and an LD50 for CS2007 could not be determined because mice did not die after inoculation with the highest dose. CS2007 also elicited protection in mice from challenge with wild type S. typhimurium" ;
    rdfs:label "clpP from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1251968; PMID: 2496146" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002623
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in clpP (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice, and an LD50 for CS2007 could not be determined because mice did not die after inoculation with the highest dose. CS2007 also elicited protection in mice from challenge with wild type S. typhimurium" ;
    rdfs:label "clpP from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1251968; PMID: 2496146" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002624
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in clpP (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice, and an LD50 for CS2007 could not be determined because mice did not die after inoculation with the highest dose. CS2007 also elicited protection in mice from challenge with wild type S. typhimurium" ;
    rdfs:label "clpP from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1251968; PMID: 2496146" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002625
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cobS mutant, in combination with a cbiA mutation, is attenuated in chickens and induces significant protection from challenge with wild type S. Gallinarum. This mutant was also able to provide some protection against S. Enteritidis" ;
    rdfs:label "cobS from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6923296; PMID: 20153354" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002626
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs" ;
    rdfs:label "cpxA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1255585; PMID: 15542179" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002627
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cpxR mutant, in combination with a lon mutation, is highly attenuated in mice and induces significant protection from challenge with wild type S. gallinarum" ;
    rdfs:label "cpxR from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6923307; PMID: 20487719" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002628
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cya and crp mutant is attenuated in mice. Thirty days after immunization, mice were protected from oral challenge with wild type S. typhimurium" ;
    rdfs:label "crp from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1254989; PMID: 3316029" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002629
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A crp mutant is attenuated in mice and induces significant protection from challenge with wild type S. gallinarum" ;
    rdfs:label "crp from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 46811321; PMID: 17488512" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002630
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cya and crp mutant is attenuated in mice. Thirty days after immunization, mice were protected from oral challenge with wild type S. typhimurium" ;
    rdfs:label "cya from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 581756; PMID: 3316029" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002631
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A fliC mutant, in combination with a guaB mutant, is attenuated in mice and chickens and induces significant protection from challenge with wild type S. enterica" ;
    rdfs:label "fliC from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 119351647; PMID: 17261603" ;
    rdfs:subClassOf obo:VO_0001422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002632
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA, clpP, and fliD mutant (CVD 1923) is attenuated in mice after oral immunization. This mutant is also protective, with a vaccine efficacy of 80% in mice against wild type challenge from Salmonella Typhimurium" ;
    rdfs:label "fliD from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1253481; PMID: 21807911" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002633
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gal E mutant in strain Ty2 was isolated, attenuated, and protected mice against lethal challenge" ;
    rdfs:label "galE from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1067209; PMID: 1092768" ;
    rdfs:subClassOf obo:VO_0001419, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002634
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1941) is attenuated in mice after oral immunization. This mutant is also protective in mice and had a vaccine efficacy of 76% against challenge with wild type Salmonella Enteritidis" ;
    rdfs:label "guaA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6948075; PMID: 21807911" ;
    rdfs:subClassOf obo:VO_0001422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002635
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "guaA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1254032; PMID: 21807911" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002636
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "guaA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1254032; PMID: 21807911" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002637
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "guaB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1254033; PMID: 21807911" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002638
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "guaB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1254033; PMID: 21807911" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002639
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaB mutant, in combination with a fliC mutant, is attenuated in mice and chickens and induced significant protection from challenge with wild type S. enterica" ;
    rdfs:label "guaB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6949287; PMID: 17261603" ;
    rdfs:subClassOf obo:VO_0001422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002640
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaB mutant, in combination with a fliC mutant, is attenuated in mice and chickens and induced significant protection from challenge with wild type S. enterica" ;
    rdfs:label "guaB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6949287; PMID: 17261603" ;
    rdfs:subClassOf obo:VO_0001422, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002641
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs" ;
    rdfs:label "gyrA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1253794; PMID: 15542179" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002642
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Oral immunization with the Salmonella hfq deletion mutant efficiently protects mice against subsequent oral challenge with virulent strain of Salmonella Typhimurium" ;
    rdfs:label "hfq from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1255887; PMID: 21347426" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002643
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A htrA mutant in Salmonella typhimurium is attenuated and provides protection in mice against an oral challenge with virulent S. typhimurium SL1344" ;
    rdfs:label "htrA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 301156836; PMID: 1584006]" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002644
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A lon mutant, in combination with a cpxR mutation, is highly attenuated in mice and induces significant protection from challenge with wild type S. gallinarum" ;
    rdfs:label "lon from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6923289; PMID: 20487719" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002645
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lppA mutant, in combination with an lppB/msbB mutation, is attenuated in mice and induces significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "lppA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 323129647; PMID: 17997275" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002646
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lppB mutant, in combination with an msbB mutant or an msbB/lppA mutant, is attenuated in mice and induces significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "lppB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 267993263; PMID: 17997275" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002647
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lppB mutant, in combination with an msbB mutant or an msbB/lppA mutant, is attenuated in mice and induces significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "lppB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 267993263; PMID: 17997275" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002648
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An msbB mutant, in combination with an lppB or lppAB mutation, is attenuated in mice and induces significant protection from challenge with S. Typhimurium" ;
    rdfs:label "msbB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 4104731; PMID: 17997275" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002649
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An msbB mutant, in combination with an lppB or lppAB mutation, is attenuated in mice and induces significant protection from challenge with S. Typhimurium" ;
    rdfs:label "msbB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 4104731; PMID: 17997275" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002650
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In a pig infection experiment including two oral immunizations with SalmoporcDeltaompD (OmpD, nmpC) and challenge with a multiresistant S. enterica serovar Typhimurium DT104 clinical isolate, we confirmed the protective efficacy of SalmoporcDeltaompD in pigs, showing a significant reduction of both clinical symptoms and colonization of lymph nodes and intestinal tract" ;
    rdfs:label "nmpC from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 517159; PMID: 17296750" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002651
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A nuoG mutant is attenuated in chickens and induced significant protection from challenge with wild type S. Gallinarum" ;
    rdfs:label "nuoG from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6924283; PMID: 9682335" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002652
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An ompR mutant is attenuated in mice after oral challenge. Twenty eight days after immunization, mice were challenged with wild type S. typhimurium and were significantly protected" ;
    rdfs:label "ompR from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 301160045; PMID: 2543631" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002653
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Three S. typhi deletion mutants (phoP, rpoS, and rpoS-phoP double mutant) were constructed and characterized with respect to invasiveness, virulence, and protective immune response compared with wild-type Ty2. All S. typhi mutants showed an increase in the specific serum IgG levels and T-cell-mediated immunity, and showed equal protection abilities against a wild-type Ty2 challenge after two rounds of immunization in BALB/c mice" ;
    rdfs:label "phoP from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1071307; PMID: 17725620" ;
    rdfs:subClassOf obo:VO_0001419, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002654
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A poxA mutant is attenuated in mice and induces significant protection from challenge with wild type S. typhimurium" ;
    rdfs:label "poxA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1255870; PMID: 9826331" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002655
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ppGpp-defective Salmonella Gallinarum, which is attained by mutating the relA and spoT genes, is attenuated in chickens and induces protection from oral challenge with wild type S. Gallinarum" ;
    rdfs:label "relA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6922678; PMID: 21046347" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002656
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An rfc mutant, in combination with an asd mutation, is attenuated in mice and induces significant protection from challenge with wild type S. typhimurium" ;
    rdfs:label "rfc from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 267993210; PMID: 20799091" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002657
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs" ;
    rdfs:label "rpoB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 255679; PMID: 15542179" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002658
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Immunizations with Salmonella typhimurium rpoS and rpoS aroA mutants protected susceptible BALB/c mice against subsequent oral challenge with virulent S. typhimurium. When administered orally or intraperitoneally, rpoS derivatives of the mouse-virulent S. typhimurium strains, C52 and SL1344, were highly attenuated and were efficient single-dose live vaccines" ;
    rdfs:label "rpoS from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 301159483; PMID: 8899717" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002659
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ruvB mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "ruvB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1253415; PMID: 20670908" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002660
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ppGpp-defective Salmonella Gallinarum, which is attained by mutating the relA and spoT genes, is attenuated in chickens and induces protection from oral challenge with wild type S. Gallinarum" ;
    rdfs:label "spoT from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 6924903; PMID: 21046347" ;
    rdfs:subClassOf obo:VO_0001420, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002661
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A surA mutant (BRD1115) is attenuated in BALB/c mice and induces protection from challenge with wild type S. typhimurium" ;
    rdfs:label "surA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1251610; PMID: 10678914" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002662
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A tolA mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "tolA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 301157338; PMID: 19118362" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002663
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A trxA mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "trxA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 301160436; PMID: 19884329" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002664
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A wecA mutant (DSM645) is attenuated in C57BL/6J mice through i.p. and oral immunization. This mutant also protects against challenge with S. typhimurium strains TML and SL1344 30 days after immunization" ;
    rdfs:label "wecA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 20140863; PMID: 22025511" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002665
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A znuABC mutant is attenuated in mice and induced significant protection against a challenge infection in the large intestine with wild type Salmonella typhimurium" ;
    rdfs:label "znuA from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 253412; PMID: 21219981" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002666
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A znuABC mutant is attenuated in mice and induced significant protection against a challenge infection in the large intestine with wild type Salmonella typhimurium" ;
    rdfs:label "znuB from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1253414; PMID: 21219981" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002667
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A znuABC mutant is attenuated in mice and induced significant protection against a challenge infection in the large intestine with wild type Salmonella typhimurium" ;
    rdfs:label "znuC from Salmonella spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 1253413; PMID: 21219981" ;
    rdfs:subClassOf obo:VO_0001421, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002668
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "aroA from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1077373; PMID: 7927802" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002669
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "aroA from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1077373; PMID: 7927802" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002670
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "aroA from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1077373; PMID: 7927802" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002671
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "aroA from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1077373; PMID: 7927802" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002672
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroD mutant is highly attenuated in monkeys and induces significant protection from challenge with wild type S. flexneri" ;
    rdfs:label "aroD from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1078189; PMID: 8356844" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002673
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroD mutant is highly attenuated in monkeys and induces significant protection from challenge with wild type S. flexneri" ;
    rdfs:label "aroD from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1078189; PMID: 8356844" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002674
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An envZ mutant (SC433) is greatly decreased in virulence in macaque monkeys, though some mild clinical signs were still recorded. This mutant is also highly protective against a challenge of wild type S. flexneri delivered 1 month after inoculation" ;
    rdfs:label "envZ from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4207729; PMID: 1887672" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002675
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "icsA/virG from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1238021; PMID: 7927802" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002676
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "icsA/virG from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1238021; PMID: 7927802" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002677
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, senB, and msbB2 mutant (WRSs3) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs3 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "msbB2 from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3670926; PMID: 19932216]" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002678
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "senA from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3671021; PMID: 19932216" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002679
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "senA from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3671021; PMID: 19932216" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002680
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "senB from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3668265; PMID: 19932216" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002681
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "senB from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3668265; PMID: 19932216" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002682
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG mutant (WRSS1) is attenuated in guinea pigs and induced significant protection from challenge with wild type Shigella sonnei" ;
    rdfs:label "virG from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3670887; PMID: 9712824" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002683
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG mutant (WRSS1) is attenuated in guinea pigs and induced significant protection from challenge with wild type Shigella sonnei" ;
    rdfs:label "virG from Shigella" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3670887; PMID: 9712824" ;
    rdfs:subClassOf obo:VO_0000169, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002684
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A hemA mutant is highly attenuated in mice and rabbits and induces protection from challenge with wild type V. cholerae in rabbits" ;
    rdfs:label "hemA from Vibrio cholerae" ;
    rdfs:seeAlso "NCBI_Protein_ID: 12656010; PMID: 16102875" ;
    rdfs:subClassOf obo:VO_0001423, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002685
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in mice, and after 3 doses induces significant protection from challenge with wild type Y. enterocolitica" ;
    rdfs:label "aroA from Yersinia enterocolitica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4713234; PMID: 2777382" ;
    rdfs:subClassOf obo:VO_0001425, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002686
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A htrA mutant in Yersinia enterocolitica was attenuated and provided partial protection against challenge in mice" ;
    rdfs:label "htrA from Yersinia enterocolitica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4715899; PMID: 8675311" ;
    rdfs:subClassOf obo:VO_0001425, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002687
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ompR mutant in Yersinia enterocolitica was attenuated and provided a partial protection from challenge in mice" ;
    rdfs:label "ompR from Yersinia enterocolitica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4716266; PMID: 9711851" ;
    rdfs:subClassOf obo:VO_0001425, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002688
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A sodA mutant in Yersinia enterocolitica was highly attenuated and mice immunized with a single oral dose of the mutant strain were protected against a lethal oral-challenge infection with wild-type Y. enterocolitica" ;
    rdfs:label "sodA from Yersinia enterocolitica" ;
    rdfs:seeAlso "NCBI_Gene_ID: 4716532; PMID: 10496939" ;
    rdfs:subClassOf obo:VO_0001425, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002689
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA mutant is attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "guaA from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1146310; PMID: 0096773" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002690
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA mutant is attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "guaB from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1146309; PMID: 0096773" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002691
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An IpxM mutant is attenuated in mice and guinea pigs. This mutant also conferred modest protection from challenge with wild type Y. pestis in Balb/c mice and significant protection in guinea pigs and outbred mice" ;
    rdfs:label "ipxM from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1174901; PMID: 17913308" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002692
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An nlpD mutant is highly attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "nlpD from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Protein_ID: 224483371; PMID: 19759820" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002693
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A pcm mutant is highly attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "pcm from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Protein_ID: 224483370; PMID: 14742535" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002694
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An smpB mutant, in combination with an ssrA mutation, is attenuated in mice and induces significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "smpB from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1173949; PMID: 20065026" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002695
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An smpB mutant, in combination with an ssrA mutation, is attenuated in mice and induces significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "ssrA from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1173948; PMID: 20065026" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002696
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A yopH mutant is highly attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "yopH from Yersinia pestis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1172712; PMID: 17652523" ;
    rdfs:subClassOf obo:VO_0001426, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002697
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A phoP mutant in Yersinia pseudotuberculosis (Yptb) was attenuated and provided protection against oral challenge with virulent Yptb in mice" ;
    rdfs:label "phoP from Yersinia pseudotuberculosis" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2956268; PMID: 17194509" ;
    rdfs:subClassOf obo:VO_0001427, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002698
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in rainbow trout and induces significant protection from challenge with wild type Y. ruckeri" ;
    rdfs:label "aroA from Yersinia ruckeri" ;
    rdfs:seeAlso "NCBI_Protein_ID: 15420539; PMID: 16083447" ;
    rdfs:subClassOf obo:VO_0001428, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002699
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient mutant (B8-D53) showed no detectable thymidine kinase-inducing activity and was attenuated in calves. B8-D53 also induced protection from challenge with wild type BHV-1" ;
    rdfs:label "UL23 from Bovine herpesvirus 1" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1487380; PMID: 2994602" ;
    rdfs:subClassOf obo:VO_0001424, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002700
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A deletion of BHV-1 gE gene in strain A is considered as a live attenuated vaccine. After challenge, vaccinated calves were protected against disease and virus shedding was reduced" ;
    rdfs:label "US8 from Bovine herpesvirus 1" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1487407; PMID: 8023552" ;
    rdfs:subClassOf obo:VO_0001424, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002701
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein G deletion in bovine respiratory syncytial virus(rBRSV) and recombinant rBRSV was attenuated and provided protection against a BRSV challenge infection in calves" ;
    rdfs:label "glycoprotein G from Bovine Respiratory Syncytial Virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1489813; PMID: 12414977" ;
    rdfs:subClassOf obo:VO_0001429, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002702
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An N269A/Q mutation in the E(rns) protein created an attenuated mutant in swine. This mutant was able to induce effective protection in swine against challenge with wild type CSFV" ;
    rdfs:label "E(rns) from Classical swine fever virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 130457; PMID: 17904607" ;
    rdfs:subClassOf obo:VO_0001430, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002703
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An N to A amino acid substitution was made in the N594 site of the E1 glycoprotein, resulting in attenuation of the virus in swine. This attenuated virus induced protection against challenge with wild type CSFV" ;
    rdfs:label "E1 from Classical swine fever virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 325461; PMID: 19203774" ;
    rdfs:subClassOf obo:VO_0001430, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002704
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A E2 mutant in Classical swine fever virus is attenuated and provides protection in pigs after oronasal vaccination (not intradermal vaccination) against lethal challenge dose of CSFV strain Eystrup" ;
    rdfs:label "E2 from Classical swine fever virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 920146; PMID: 15837238" ;
    rdfs:subClassOf obo:VO_0001430, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002705
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein E mutant is attenuated in mice and hamsters and induced significant protection from challenge with wild type Equid herpesvirus in mice" ;
    rdfs:label "gE from Equid herpesvirus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 330789; PMID: 17085880" ;
    rdfs:subClassOf obo:VO_0001431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002706
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein I mutant is attenuated in mice and hamsters and induced significant protection from challenge with wild type Equid herpesvirus in mice" ;
    rdfs:label "gI from Equid herpesvirus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 330788; PMID: 17085880" ;
    rdfs:subClassOf obo:VO_0001431, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002707
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient mutant (PR1) is attenuated in mice and induced significant protection from challenge with wild type EHV-1 5 weeks after vaccination. In foals, PR1 also showed attenuation; however, the mutant induced only partial protection from challenge with EHV-1" ;
    rdfs:label "TK from Equid herpesvirus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 59214; PMID: 16930871" ;
    rdfs:subClassOf obo:OBI_0000011 .

obo:VO_0002708
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient mutant (C7301dlTK) is attenuated in cats and induced significant protection from wild type FHV-1 4 weeks after vaccination" ;
    rdfs:label "UL23 from Feline herpesvirus 1" ;
    rdfs:seeAlso "NCBI_Gene_ID: 8658565; PMID: 8645090" ;
    rdfs:subClassOf obo:VO_0001432, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002709
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Feline immunodeficiency virus (FIV) made defective in the accessory gene ORF-A were previously shown to be greatly attenuated in its ability to replicate in lymphocytes but to grow normally or near normally in other cell types. 3/9 vaccinees (cats) showed no evidence of the challenge virus over a 15-month observation period. In the other vaccinees, the challenge virus was predominant for various periods of time, but pre-existing viral loads and CD4 lymphocyte counts were either unaffected or altered only marginally and transiently" ;
    rdfs:label "ORF-A from Feline immunodeficiency virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1724707; PMID: 15680433" ;
    rdfs:subClassOf obo:VO_0001433, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002710
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A vif mutant in feline immunodeficiency virus was attenuated and FIV-pPPRΔvif proviral DNA protected cats against challenge with the homologous FIV-PPR biological isolate." ;
    rdfs:label "vif from Feline immunodeficiency virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1724709; PMID: 10891409" ;
    rdfs:subClassOf obo:VO_0001433, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002711
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "3a from Feline infectious peritonitis virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 10040181; PMID: 15047802" ;
    rdfs:subClassOf obo:VO_0001434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002712
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "3b from Feline infectious peritonitis virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 10040182; PMID: 15047802" ;
    rdfs:subClassOf obo:VO_0001434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002713
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "3c from Feline infectious peritonitis virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 10040183; PMID: 15047802" ;
    rdfs:subClassOf obo:VO_0001434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002714
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 7ab deletion mutant in Feline infectious peritonitis virus is attenuated and provides protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "7a from Feline infectious peritonitis virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 10040187; PMID: 15047802" ;
    rdfs:subClassOf obo:VO_0001434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002715
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 7ab deletion mutant in Feline infectious peritonitis virus is attenuated and provides protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "7b from Feline infectious peritonitis virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 10040188; PMID: 15047802" ;
    rdfs:subClassOf obo:VO_0001434, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002716
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL0 mutant in infectious laryngotracheitis virus (ILTV) was attenuated. Chickens immunized with UL0-negative ILTV were protected from clinical disease after subsequent infection with virulent ILTV" ;
    rdfs:label "UL0 from Gallid herpesvirus 1" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3239037; PMID: 14645915" ;
    rdfs:subClassOf obo:VO_0001435, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002717
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine-kinase mutant is attenuated in chickens and induced protection from challenge with wild type GHV-1" ;
    rdfs:label "UL23 from Gallid herpesvirus 1" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3239035; PMID: 12021870" ;
    rdfs:subClassOf obo:VO_0001435, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002718
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL47 mutant in avian infectious laryngotracheitis virus is attenuated and provides protection in chicken against subsequent challenge infection with virulent ILTV" ;
    rdfs:label "UL47 from Gallid herpesvirus 1" ;
    rdfs:seeAlso "NCBI_Gene_ID: 3239064; PMID: 17325345" ;
    rdfs:subClassOf obo:VO_0001435, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002719
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Researchers generated a series of woodchuck hepatitis virus (WHV) X mutants. Woodchucks inoculated with X mutants, including those with no serologic evidence of infection, were protected from later challenge with infectious Woodchuck Hepatitis Virus, suggesting previous infection with resulting protective immunity" ;
    rdfs:label "HBVgp3 X protein from Hepatitis B virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 944566; PMID: 11714744" ;
    rdfs:subClassOf obo:VO_0001436, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002720
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "KOS-gDA3C is attenuated with mutations in gD gene in causing skin lesions at the inoculation and zosteriform sites, yet it is as effective as rKOS-gDA3C in protecting mice against HSV-1 challenge" ;
    rdfs:label "gD from Herpes simplex virus type 1 and 2" ;
    rdfs:seeAlso "NCBI_Protein_ID: 19548971; PMID: 18243431" ;
    rdfs:subClassOf obo:VO_0001437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002721
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gH mutant is attenuated in mice and induces significant protection from challenge with wild type HSV-1" ;
    rdfs:label "gH from Herpes simplex virus type 1 and 2" ;
    rdfs:seeAlso "NCBI_Protein_ID: 138315; PMID: 8289395" ;
    rdfs:subClassOf obo:VO_0001437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002722
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A live-attenuated HSV-2 ICP0 virus provides significant protection against wild-type HSV-2 (MS strain) challenge in mice" ;
    rdfs:label "iCP0 from Herpes simplex virus type 1 and 2" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1487289; PMID:  21412438" ;
    rdfs:subClassOf obo:VO_0001454, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002723
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient (TK) mutant was found to be attenuated in mice. This mutant induced complete protection from challenge with wild type HSV" ;
    rdfs:label "TK from Herpes simplex virus type 1 and 2" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2703374; PMID: 212476" ;
    rdfs:subClassOf obo:VO_0001437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002724
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL29 mutant is attenuated in mice and induces significant protection from challenge with wild type HSV-1" ;
    rdfs:label "UL29 from Herpes simplex virus type 1 and 2" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2703458; PMID: 8289372" ;
    rdfs:subClassOf obo:VO_0001437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002725
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An HSV-1 gE (Us8) deletion strain, NS-gEnull, was used as a live attenuated vaccine. After HSV-1 challenge, latent virus was recovered by DRG explant cocultures from <10% of vaccinated mice compared with 100% of mock-vaccinated mice" ;
    rdfs:label "US8 from Herpes simplex virus type 1 and 2" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2703448; PMID: 18562543" ;
    rdfs:subClassOf obo:VO_0001437, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002726
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A G mutant is attenuated in African green monkeys and induces protection from challenge with wild type HMPV" ;
    rdfs:label "G protein from Human metapneumovirus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 75549950; PMID: 16160190" ;
    rdfs:subClassOf obo:VO_0001438, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002727
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An M2-2 mutant is attenuated in African green monkeys and induced protection from challenge with wild type HMPV" ;
    rdfs:label "M2-2 from Human metapneumovirus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 75549952; PMID: 16160190" ;
    rdfs:subClassOf obo:VO_0001438, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002728
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An M2-2 mutant of human respiratory syncytial virus A2 is attenuated in African green monkeys. When challenged with wild type RSV, two doses provided complete protection against challenge in the lower respiratory tract and a significant reduction of the challenge virus in the upper respiratory tract" ;
    rdfs:label "M2-2 from Human Respiratory Syncytial Virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 81925031; PMID: 12922094" ;
    rdfs:subClassOf obo:VO_0001439, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002729
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in the non-virion protein of IHNV causes attenuated growth in rainbow trout and is able to provide significant protection from subsequent challenge with wild type IHNV" ;
    rdfs:label "NV from Infectious Hematopoietic Necrosis Virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1489849; PMID: 15047826" ;
    rdfs:subClassOf obo:VO_0001440, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002730
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mutant influenza virus that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) from Influenza A virus (A/Puerto Rico/8/34(H1N1)) is attenuated in both cell culture and mice. Mice intranasally vaccinated with M2KO virus developed protective immune responses and survived a lethal challenge with the wild-type virus, suggesting that the M2KO virus has potential as a live attenuated vaccine" ;
    rdfs:label "M2 from Influenza virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 956528; PMID: 19321619" ;
    rdfs:subClassOf obo:VO_0000185, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002731
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Intranasal inoculation of mice, pigs, horses, and macaques with NS1-modified influenza virus strains induced robust humoral and cellular immune responses, and generated immune protection against challenge with wild-type virus" ;
    rdfs:label "NS1 from Influenza virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 505039; PMID: 19768406" ;
    rdfs:subClassOf obo:VO_0000185, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002732
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in the GP5 protein attenuates HP-PRRSV in piglets. This mutant (HuN4-F112) induces protection against challenge with wild type HP-PRRSV" ;
    rdfs:label "GP5 protein from Porcine respiratory and reproductive syndrome virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 149389584; PMID: 19339125" ;
    rdfs:subClassOf obo:VO_0001441, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002733
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein E mutant, in combination with UL23 and glycoprotein G mutations, is attenuated in raccoons, with a 75% survival rate. This mutant also provides some protection from wild type PRV" ;
    rdfs:label "glycoprotein E from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 307634504; PMID: 12488067" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002734
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein G mutant, in combination with UL23 and glycoprotein E mutations, is attenuated in raccoons, with a 75% survival rate. This mutant also provides some protection from wild type PRV" ;
    rdfs:label "glycoprotein G from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 15422177; PMID: 12488067" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002735
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein M, gM, deletion in pseudorabies virus was attenuated and induced protection in piglets against intranasal challenge with 108 p.f.u. of the highly virulent PrV strain NIA-3" ;
    rdfs:label "glycoprotein M from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 1478255; PMID: 9292000" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002736
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gp50+gp63 deletion mutant in Pseudorabies virus was attenuated and provided protection from clinical signs of Aujeszky's disease after a challenge inoculation with the virulent wild-type PRV strain NIA-3" ;
    rdfs:label "gp50 from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2952548; PMID: 8178562" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002737
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gp50+gp63 deletion mutant in Pseudorabies virus was attenuated and provided protection from clinical signs of Aujeszky's disease after a challenge inoculation with the virulent wild-type PRV strain NIA-3" ;
    rdfs:label "gp63 from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2952540; PMID: 8178562" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002738
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL23 mutant, in combination with mutations in glycoproteins G and E, is attenuated in raccoons, with a 75% survival rate. This mutant also provides some protection from wild type PRV" ;
    rdfs:label "UL23 from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2952559; PMID: 12488067" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002739
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL50 mutant is attenuated in pseudorabies virus and induces significant protection in pigs from challenge with the highly virulent NIA-3 strain of PrV" ;
    rdfs:label "UL50 from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2952537; PMID: 9228681" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002740
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Researchers intranasally inoculated pigs, the natural host of this virus, with mutant PRV strains in which the genes encoding the protein kinase (US3) proteins were inactivated. After challenge infection with the virulent PRV strain NIA-3, no virus was excreted by wt PRV- and PK- mutant-immunized animals, indicating complete protective immunity" ;
    rdfs:label "US3 from Pseudorabies virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 2952561; PMID: 7975253" ;
    rdfs:subClassOf obo:VO_0001442, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002741
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein G mutant in rabies virus is attenuated. After a one-dose intramuscular vaccination, the ERAg3m virus protected 100% of mice and hamsters from lethal challenge. In co-infections, using a lethal dose of street rabies virus mixed with ERAg3m, 100% of hamsters and 90% of mice survived and were protected against subsequent infection" ;
    rdfs:label "glycoprotein G from Rabies virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1489856; PMID: 21514343" ;
    rdfs:subClassOf obo:VO_0001443, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002742
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A P gene mutant is attenuated in mice and induces significant protection from challenge with wild type Rabies virus" ;
    rdfs:label "P protein from Rabies virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 291220682; PMID: 15896403" ;
    rdfs:subClassOf obo:VO_0001443, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002743
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An E mutant is attenuated in hamsters and induces significant protection from challenge with wild type SARS" ;
    rdfs:label "E from SARS-CoV" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1489671; PMID: 18463152" ;
    rdfs:subClassOf obo:VO_0001444, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002744
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A SIV nef mutant is attenuated in rhesus monkeys and induces protection from challenge with wild type SIV" ;
    rdfs:label "nef from Simian Immunodeficiency Virus" ;
    rdfs:seeAlso "NCBI_Gene_ID: 1490008; PMID: 1470917" ;
    rdfs:subClassOf obo:VO_0001445, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002745
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virus with a mutation in protein C is attenuated in mice and induced protection from challenge with wild type TBE virus" ;
    rdfs:label "C protein from Tick-borne Encephalitis Virus (TBEV)" ;
    rdfs:seeAlso "NCBI_Protein_ID: 206570298; PMID: 11884577" ;
    rdfs:subClassOf obo:VO_0001446, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002746
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A VEE mutant with a PE2 cleavage signal mutation and a suppressor mutation in E1 is highly attenuated in mice and provides complete protection against challenge with wild type VEE" ;
    rdfs:label "E1 glycoprotein from VEE Virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 798795; PMID: 7676619" ;
    rdfs:subClassOf obo:VO_0001447, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002747
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A VEE mutant with a PE2 cleavage signal mutation and a suppressor mutation in E1 is highly attenuated in mice and provides complete protection against challenge with wild type VEE" ;
    rdfs:label "PE2 from VEE Virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 229558446; PMID: 7676619" ;
    rdfs:subClassOf obo:VO_0001447, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002748
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virus with a C protein mutation is attenuated in mice and induces significant protection from challenge with wild type West Nile virus" ;
    rdfs:label "C protein from West Nile virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 158516889; PMID: 20600500" ;
    rdfs:subClassOf obo:VO_0001448, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002749
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "E1 from Western equine encephalomyelitis virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 17148717; PMID: 12641414" ;
    rdfs:subClassOf obo:VO_0001449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002750
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "E1 from Western equine encephalomyelitis virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 17148717; PMID: 12641414" ;
    rdfs:subClassOf obo:VO_0001449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002751
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E2 (WE2102) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "E2 from Western equine encephalomyelitis virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 29611992; PMID: 12641414" ;
    rdfs:subClassOf obo:VO_0001449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002752
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E2 (WE2102) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "E2 from Western equine encephalomyelitis virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 29611992; PMID: 12641414" ;
    rdfs:subClassOf obo:VO_0001449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002753
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with either a deletion in E2 (WE2102) or E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of these two strains would occur" ;
    rdfs:label "PE2 from Western equine encephalomyelitis virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 90811336; PMID: 12641414" ;
    rdfs:subClassOf obo:VO_0001449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002754
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with either a deletion in E2 (WE2102) or E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of these two strains would occur" ;
    rdfs:label "PE2 from Western equine encephalomyelitis virus" ;
    rdfs:seeAlso "NCBI_Protein_ID: 90811336; PMID: 12641414" ;
    rdfs:subClassOf obo:VO_0001449, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002755
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cen1 mutant is attenuated in mice and hamsters and induces significant protection from challenge with wild type L. donovani" ;
    rdfs:label "cen1 from Leishmania donovani" ;
    rdfs:seeAlso "NCBI_Protein_ID: 15488542; PMID: 19592661" ;
    rdfs:subClassOf obo:VO_0001450, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002756
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A Leishmania infantum deletion mutant of HSP70-II gene is attenuated and provides protection against Leishmania infection in the L. major-BALB/c infection model. Also, DeltaHSP70-II is a safe live vaccine as immunodeficient SCID mice, and hamsters, infected with mutant parasites did not develp any sign of pathology" ;
    rdfs:label "HSP70 II from Leishmania infantum" ;
    rdfs:seeAlso "NCBI_Gene_ID: 5073319; PMID: 21794145" ;
    rdfs:subClassOf obo:VO_0002515, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002757
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A genetically attenuated parasite (GAP) with a mutation in the FabB/FabF gene is attenuated in mice by arresting in the late liver stage. It also conferred complete protection in mice from challenge with wild type Plasmodium" ;
    rdfs:label "fabB/fabF from Plasmodium spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 3885996; PMID: 21669394" ;
    rdfs:subClassOf obo:VO_0000172, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002758
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Genetically attenuated P36p-deficient Plasmodium berghei sporozoites provide protection against sporozoites challenge in mice" ;
    rdfs:label "p36p from Plasmodium spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 3424772; PMID: 7604034" ;
    rdfs:subClassOf obo:VO_0001451, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002759
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice. Mice immunized with the mutant were completely protected against challenge with wild type Plasmodium sporozoites" ;
    rdfs:label "py36 from Plasmodium spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 23479924; PMID: 17517871" ;
    rdfs:subClassOf obo:VO_0001452, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002760
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice. Mice immunized with the mutant were completely protected against challenge with wild type Plasmodium sporozoites" ;
    rdfs:label "py52 from Plasmodium spp." ;
    rdfs:seeAlso "NCBI_Protein_ID: 15193062; PMID: 17517871" ;
    rdfs:subClassOf obo:VO_0001452, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002761
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of UIS3 in Plasmodium yoelii provided attenuation and full protection in mice by Pyuis3(-) sporozoites required at least 2 immunizations against challenges with infectious sporozoites" ;
    rdfs:label "UIS3 from Plasmodium spp." ;
    rdfs:seeAlso "NCBI_Gene_ID: 3830198; PMID: 17624848" ;
    rdfs:subClassOf obo:VO_0001452, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002762
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mic2 mutant is attenuated in mice and induces protection from challenge with wild type T. gondii" ;
    rdfs:label "mic2 from Toxoplasma gondii" ;
    rdfs:seeAlso "NCBI_Protein_ID: 1923217; PMID: 16933991" ;
    rdfs:subClassOf obo:VO_0001453, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002763
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An OMPDC mutant, alone or in combination with an UP mutation, is attenuated in mice and induces significant protection from challenge with wild type T. gondii" ;
    rdfs:label "OMPDC from Toxoplasma gondii" ;
    rdfs:seeAlso "NCBI_Gene_ID: 7899615; PMID: 20605980" ;
    rdfs:subClassOf obo:VO_0001453, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002764
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An OMPDC mutant, alone or in combination with an UP mutation, is attenuated in mice and induces significant protection from challenge with wild type T. gondii" ;
    rdfs:label "OMPDC from Toxoplasma gondii" ;
    rdfs:seeAlso "NCBI_Gene_ID: 7899615; PMID: 20605980" ;
    rdfs:subClassOf obo:VO_0001453, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002765
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UP mutant, in combination with an OMPDC mutation, is attenuated in mice and induces significant protection from wild type T. gondii" ;
    rdfs:label "UP from Toxoplasma gondii" ;
    rdfs:seeAlso "NCBI_Gene_ID: 900273; PMID: 20605980" ;
    rdfs:subClassOf obo:VO_0001453, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0001361
    ] .

obo:VO_0002766
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "The mutant strain, with deletion of apxIA gene, obtained in this study offered a level of cross-serovar protection against A. pleuropneumoniae infection in mice and pigs (Reference: PMID: 16930871)." ;
    rdfs:label "Actinobacillus pleuropneumoniae apxIA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002767
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In the intra-peritoneal mouse model, the virulence of the mutant strain decreased at least 100 fold compared with the parent strain. The mutant was evaluated as a potential vaccine using a vaccination-challenge trial. The death number and lung lesion score in the vaccinated pigs given the serovar 1 challenge were obviously lower than those in the unvaccinated pigs" ;
    rdfs:label "Actinobacillus pleuropneumoniae ApxIC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002768
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion in ureC and apxIIA genes of Actinobacillus pleuropneumoniae serotype 2 prototype provides attenuation and protection in pigs against challenge with the virulent parent strain of A. pleuropneumoniae" ;
    rdfs:label "Actinobacillus pleuropneumoniae ureC and apxIIA double mutant deletion vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002769
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In the present study, the gene encoding the ApxII-activating protein, apxIIC, was insertionally inactivated on the chromosome of a serovar 7 strain, HS93. Pigs vaccinated with live HS93C-Ampr via the intranasal route were protected against a cross-serovar challenge with a virulent serovar 1 strain of A. pleuropneumoniae" ;
    rdfs:label "Actinobacillus pleuropneumoniae apxIIC and apxIVA double deletion mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002770
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In the present study, the gene encoding the ApxII-activating protein, apxIIC, was insertionally inactivated on the chromosome of a serovar 7 strain, HS93. Pigs vaccinated with live HS93C-Ampr via the intranasal route were protected against a cross-serovar challenge with a virulent serovar 1 strain of A. pleuropneumoniae" ;
    rdfs:label "A. pleuropneumoniae HS93C-Ampr" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002771
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An apxIIIB mutant, in combination with an apxIIID mutation, is highly attenuated in pigs and induces significant protection from challenge with wild type A. pleuropneumoniae. The mutant also was slightly attenuated in mice and induced protection in mice against challenge from the parent strain" ;
    rdfs:label "Actinobacillus pleuropneumoniae apxIIIB and apxIIID double mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002772
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An apxIIID mutant, in combination with an apxIIIB mutation, is highly attenuated in pigs and induces significant protection from challenge with wild type A. pleuropneumoniae. The mutant also was slightly attenuated in mice and induced protection in mice against challenge from the parent strain" ;
    rdfs:label "Actinobacillus pleuropneumoniae apxIIIB and apxIIID double mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002773
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A precisely defined DeltaapxIICDeltaapxIVA double-deletion mutant of A. pleuropneumoniae was constructed based on HB04C(-) by transconjugation and counterselection. The results demonstrated that the DeltaapxIICDeltaapxIVA double mutant strain was less virulent than HB04C(-). Despite attenuation of virulence, the DeltaapxIICDeltaapxIVA double mutant remains immunogenic and conferred a similar level of protective immunity to pigs against challenge with a lethal dose of a heterologous fully virulent standard serovar 1 strain of A. pleuropneumoniae. (Reference: PubMed: 17767980)" ;
    rdfs:label "Actinobacillus pleuropneumoniae apxIIC and apxIVA double deletion mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002774
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection. The double-mutant contains no foreign DNA, is highly attenuated, protects pigs from homologous challenge upon a single aerosol application" ;
    rdfs:label "Actinobacillus pleuropneumoniae ureC and apxIIA double mutant deletion vaccine" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0002775
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An mntA deletion mutant, generated by allelic replacement, in Bacillus anthracis was attenuated and provided protection for guinea pigs against lethal spore dose (60 LD50) of the virulent B. anthracis Vollum strain" ;
    rdfs:label "Bacillus anthracis mntA deletion mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000013 .

obo:VO_0002776
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An actA mutant is attenuated in mice and induced significant protection from challenge with wild type L. monocytogenes" ;
    rdfs:label "Listeria monocytogenes actA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002500 .

obo:VO_0002777
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An actA mutant is attenuated in mice and induced significant protection from challenge with wild type L. monocytogenes" ;
    rdfs:label "Listeria monocytogenes actA/plcB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002500 .

obo:VO_0002778
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A plcB mutant, in combination with an actA mutant, is attenuated in mice and induces significant protection from challenge with wild type L. monocytogenes" ;
    rdfs:label "Listeria monocytogenes actA/plcB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002500 .

obo:VO_0002779
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A M. avium relA mutant is attenuated in calves and goats. This mutant also elicited an immune response in goats that limited colonization by challenge wild type M. avium" ;
    rdfs:label "Mycobacterium avium relA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000818 ;
        owl:someValuesFrom obo:VO_0002529
    ] .

obo:VO_0002780
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A drrC mutant is highly attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "Mycobacterium tuberculosis drrC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_1773
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:OGG_3000888491
                ]
            )
        ]
    ] .

obo:VO_0002781
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An fadD26 mutant is attenuated in mice and induced significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "Mycobacterium tuberculosis fadD26 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_1773
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:OGG_3000887603
                ]
            )
        ]
    ] .

obo:VO_0002782
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of leuD gene was shown to be highly attenuated. Immunocompetent BALB/c mice vaccinated with the DleuD auxotroph were protected as well as BCG in terms of survival following an intravenous or aerosol challenge with virulent M. tuberculosis" ;
    rdfs:label "Mycobacterium tuberculosis leuD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_1773
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:OGG_3000888225
                ]
            )
        ]
    ] .

obo:VO_0002783
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A lysA mutant, in combination with a secA2 mutation, is highly attenuated in mice and induced significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "Mycobacterium tuberculosis lysA/secA2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_1773
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom [
                        a owl:Class ;
                        owl:intersectionOf (obo:OGG_3000885594
                            obo:OGG_3000886960
                        )
                    ]
                ]
            )
        ]
    ] .

obo:VO_0002784
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A Mce-2 mutant in Mycobacterium tuberculosis is attenuated and provides protection against challenge for mice" ;
    rdfs:label "Mycobacterium tuberculosis mce-2/mce-3 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0002785
    obo:IAO_0000115 "A viral vaccine that protects against infection with Chikungunya virus" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "chikungunya virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_37124
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_37124
    ] .

obo:VO_0002786
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A panCD mutant is attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "Mycobacterium tuberculosis panCD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_1773
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom [
                        a owl:Class ;
                        owl:intersectionOf (obo:OGG_3000885459
                            obo:OGG_3000885596
                        )
                    ]
                ]
            )
        ]
    ] .

obo:VO_0002787
    obo:IAO_0000115 "RD1 and panCD mutants in Mycobacterium tuberculosis were attenuated and provided protection in CD4-deficient mice against an aerosol challenge with virulent M. tuberculosis" ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A panCD mutant is attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis" ;
    rdfs:label "Mycobacterium tuberculosis RD1/panCD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0002788
    obo:IAO_0000115 "a bacterial vaccine against Streptococcus suis infection" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Streptococcus suis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000772, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1307
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1307
    ] .

obo:VO_0002789
    obo:IAO_0000115 "a diphtheria vaccine against infection with Corynebacterium pseudotuberculosis" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Corynebacterium pseudotuberculosis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000735, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1719
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1719
    ] .

obo:VO_0002790
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Study evaluated immunogenicity and protection against Mycobacterium tuberculosis in rhesus monkeys with an attenuated M. tuberculosis with a disrupted phoP gene (SO2) as a single-dose vaccine. SO2 treatment showed reduced average lung bacterial counts (1.0 and 1.2 log respectively, compared with 0.4 log for BCG) and significant protective effect by reduction in C-reactive protein levels, body weight loss, and decrease of erythrocyte-associated hematologic parameters (MCV, MCH, Hb, Ht) as markers of inflammatory infection, all relative to non-vaccinated controls" ;
    rdfs:label "M. tuberculosis phoP mutant SO2" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0002791
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A proC mutant is highly attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis that is equal to the protection induced by the current vaccine BCG" ;
    rdfs:label "Mycobacterium tuberculosis proC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0002792
    obo:IAO_0000115 "A protozoan vaccine against Trichinella spiralis infection" ;
    obo:IAO_0000117 "YH, RS, NF" ;
    a owl:Class ;
    rdfs:label "Trichinella spiralis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5867
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5867
    ] .

obo:VO_0002793
    obo:IAO_0000115 "A vaccine that prevents or treats atherosclerosis disease." ;
    obo:IAO_0000117 "YH, RS" ;
    obo:IAO_0000119 "http://www.onlinejacc.org/content/64/25/2779" ;
    a owl:Class ;
    rdfs:label "atherosclerosis vaccine"@en ;
    rdfs:subClassOf obo:VO_0002813 .

obo:VO_0002794
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Vaccination of mice and guinea pigs with a secA2 mutant significantly increased resistance to M. tuberculosis challenge compared with standard M. bovis bacille Calmette-Guérin vaccination" ;
    rdfs:label "M. tuberculosis secA2 mutant" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0002795
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A sigE mutant is highly attenuated in mice and induced significant protection from challenge with wild type M. tuberculosis, more so than the existing vaccine BCG" ;
    rdfs:label "Mycobacterium tuberculosis sigE mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_1773
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:OGG_3000888751
                ]
            )
        ]
    ] .

obo:VO_0002796
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A trpD mutant is highly attenuated in mice and induces more protection from challenge with wild type M. tuberculosis than that induced by the current vaccine BCG" ;
    rdfs:label "Mycobacterium tuberculosis trpD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_1773
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:OGG_3000887681
                ]
            )
        ]
    ] .

obo:VO_0002797
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is attenuated in mice and induced significant protection from challenge with wild type S. aureus" ;
    rdfs:label "Staphylococcus aureus aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002502 .

obo:VO_0002798
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A vicK mutant is attenuated in mice and induced protection from challenge with wild type S. equi" ;
    rdfs:label "Streptococcus equi vicK mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000948 .

obo:VO_0002799
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An A. hydrophila aroA mutant is highly attenuated in trout, and a single immunization conferred significant protection from challenge with wild type A. hydrophila" ;
    rdfs:label "Aeromonas hydrophila aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002505 .

obo:VO_0002800
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "The aroA gene was inactivated by inserting a fragment expressing kanamycin resistance within the coding sequence and challenged in fish. The LD50 for unvaccinated fish was 71. In contrast, the LD50 was 1.8 x 104 in fish vaccinated once and 3 x 105 in fish vaccinated twice" ;
    rdfs:label "A. salmonicida live-attenuated vaccine encoding AroA" ;
    rdfs:subClassOf obo:VO_0000820 .

obo:VO_0002801
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of the aroA gene highly attenuates B. bronchiseptica, severely impairing its ability to colonize and survive in the respiratory tract of mice. Upon challenge with wild type B. bronchiseptica, the mice immunised with live attenuated B. bronchiseptica aroA mutant had rapidly reduced numbers of B. bronchiseptica in their respiratory tract" ;
    rdfs:label "Bordetella bronchiseptica aroA mutant vaccine (strain BBS18)" ;
    rdfs:subClassOf obo:VO_0000394 .

obo:VO_0002802
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of the aroA gene highly attenuates B. bronchiseptica, severely impairing its ability to colonize and survive in the respiratory tract of mice. Upon challenge with wild type B. bronchiseptica, the mice immunised with live attenuated B. bronchiseptica aroA mutant had rapidly reduced numbers of B. bronchiseptica in their respiratory tract" ;
    rdfs:label "Bordetella bronchiseptica aroA/trpE mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000394 .

obo:VO_0002803
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A double mutant strain of Bordetella Bronchiseptica lacking adenylate cyclase(cyaA gene) and type III secretion(bscN gene) is attenuated and provides protection in mice against 5 × 105 CFU of RB50, the B. Bronchiseptica parent strain" ;
    rdfs:label "Bordetella bronchiseptica bscN and cyaA double mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000394 .

obo:VO_0002804
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A double mutant strain of Bordetella Bronchiseptica lacking adenylate cyclase(cyaA gene) and type III secretion(bscN gene) is attenuated and provides protection in mice against 5 × 105 CFU of RB50, the B. Bronchiseptica parent strain" ;
    rdfs:label "Bordetella bronchiseptica bscN and cyaA double mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000394 .

obo:VO_0002805
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A dnt mutant in Bordetella bronchiseptica was attenuated and provides protection in guinea pigs against intranasal challenge with strain L3" ;
    rdfs:label "Bordetella bronchiseptica dnt mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000394 .

obo:VO_0002806
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A trpE mutant, in combination with an aroA mutation, is attenuated in mice and induces significant protection from challenge with wild type B. bronchiseptica" ;
    rdfs:label "Bordetella bronchiseptica aroA/trpE mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000394 .

obo:VO_0002807
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in mice and induces significant protection from challenge with wild type B. pertussis" ;
    rdfs:label "Bordetella pertussis aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000765 .

obo:VO_0002808
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A live attenuated B. pertussis vaccine strain BPZE1, developed by deleting dnt gene, protects mice upon a single intranasal administration" ;
    rdfs:label "Bordetella pertussis dnt mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000765 .

obo:VO_0002809
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A flagella-less mutant of Borrelia burgdorferi (HB19Fla-) was attenuated in immunodeficient SCID mice. Mice were challenged 28 days later with virulent strain Sh. 2 and were protected from challenge" ;
    rdfs:label "Borrelia burgdorferi fla mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000764 .

obo:VO_0002810
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A asp24 mutation in Brucella abortus is attenuated and provides significant protection in mice" ;
    rdfs:label "B. abortus and B. melitensis mutants with unmarked deletion of asp24, virB2, or manBA" ;
    rdfs:subClassOf obo:VO_0001134 .

obo:VO_0002811
    obo:IAO_0000115 "A vaccine that prevents or treats diabetes." ;
    obo:IAO_0000117 "YH, RS" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/12956615" ;
    a owl:Class ;
    rdfs:label "diabetes vaccine"@en ;
    rdfs:subClassOf obo:VO_0002813 .

obo:VO_0002812
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Brucella DeltaexsA mutant showed decreased survival in mice compared to the survival of parental strain S2308. This demonstrated that ExsA is critical for full bacterial virulence. The B. abortus exsA deletion mutant was used as a live vaccine candidate. Challenge experiments revealed that the exsA mutant strain induced superior protective immunity in BALB/c mice compared to the protective immunity induced by strain S19 or RB51" ;
    rdfs:label "Brucella abortus exsA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001134 .

obo:VO_0002813
    obo:IAO_0000115 "A vaccine that prevents or treats a non-infectious disease." ;
    obo:IAO_0000117 "YH, RS" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/12831367" ;
    a owl:Class ;
    rdfs:comment "There are mainly five types of non-infectious diseases, which are diabetes, allergies, cardiovascular diseases, cancer and genetic diseases. URL: http://www.ychlpyss.edu.hk/~bio/share/0405/f6homework/Non-infectious%20disease/noninfectiousdisease(ths).htm" ;
    rdfs:label "non-infectious disease vaccine"@en ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0002814
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mutants manB and manA were attenuated in Brucella melitensis and provided protection against challenge in mice's livers", "Unmarked rough B. abortus and B. melitensis deletion mutants of manBA (including manA and manB) were attenuated. These mutants provided protection against virulent Brucella challenge in mice" ;
    rdfs:label "B. abortus and B. melitensis mutants with unmarked deletion of asp24, virB2, or manBA" ;
    rdfs:subClassOf obo:VO_0001135 .

obo:VO_0002815
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mucR mutant has a significantly reduced degree of colonization in mice and protects against wild type B. melitensis 16M" ;
    rdfs:label "B. melitensis mucR mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_29459
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:VO_0002565
                ]
            )
        ]
    ] .

obo:VO_0002816
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A omp25 mutant is attenuated and provides protection against challenge in mice" ;
    rdfs:label "B. melitensis omp25 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_29459
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:VO_0002566
                ]
            )
        ]
    ] .

obo:VO_0002817
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A omp31 mutant in Brucella melitensis was attenuated and provided protection against challenge in mice" ;
    rdfs:label "B. melitensis omp31 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001135, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_29459
                [
                    a owl:Restriction ;
                    owl:onProperty obo:VO_0001039 ;
                    owl:someValuesFrom obo:VO_0002567
                ]
            )
        ]
    ] .

obo:VO_0002818
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A pgk mutant is attenuated in mice and induces significant protection from challenge with wild type B. abortus" ;
    rdfs:label "Brucella abortus pgk mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001134 .

obo:VO_0002819
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A pgm mutant is attenuated in mice and induces significant protection from challenge with wild type B. abortus" ;
    rdfs:label "Brucella abortus pgm mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001134 .

obo:VO_0002820
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mice infected with delta purE201 developed only five to eight times normal spleen weight at 1 week p.i. and produced no interleukin-6 in their serum, which is much lower than the mice infected with the parental strain (16M)" ;
    rdfs:label "B. melitensis WR201 (16MΔpurEK)" ;
    rdfs:subClassOf obo:VO_0001135 .

obo:VO_0002821
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A purE/purK mutant of B. melitensis 16M was attenuated in mice when given intraperitoneally. Nine weeks after immunization, mice were protected from challenge with wild type B. melitensis" ;
    rdfs:label "B. melitensis WR201 (16MΔpurEK)" ;
    rdfs:subClassOf obo:VO_0001135 .

obo:VO_0002822
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virB2 mutant is attenuated in Brucella melitensis and provides protection in mice" ;
    rdfs:label "B. abortus and B. melitensis mutants with unmarked deletion of asp24, virB2, or manBA" ;
    rdfs:subClassOf obo:VO_0001134 .

obo:VO_0002823
    obo:IAO_0000115 "A vaccine that prevents or treats arthritis." ;
    obo:IAO_0000117 "YH, RS" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/12956615" ;
    a owl:Class ;
    rdfs:label "arthritis vaccine"@en ;
    rdfs:subClassOf obo:VO_0002813 .

obo:VO_0002824
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of gene znuA attenuates Brucella abortus and this live attenuated vaccine was challenged in mice. These mice showed significantly fewer spenic CFU" ;
    rdfs:label "live attenuated B. abortus with deletion of znuA" ;
    rdfs:subClassOf obo:VO_0001134 .

obo:VO_0002825
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "The aroC deletion in the resultant mutant, designated A2ΔaroC, was confirmed by PCR, Southern hybridization and failure of the mutant to grow in a defined medium without aromatic compounds. The constructed unmarked aroC mutant of B. pseudomallei is attenuated in both BALB/c and C57Bl/6 mice and is able to confer significant protection in C57Bl/6 mice" ;
    rdfs:label "Burkholderia pseudomallei aroC deletion mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012175 .

obo:VO_0002826
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An asd mutant is highly attenuated in mice. This mutant was also able to protect against acute inhalation melioidosis caused by challenge with wild type B. pseudomallei" ;
    rdfs:label "Burkholderia pseudomallei asd mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012175 .

obo:VO_0002827
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mice that were challenged with a higher dose of mutant 56:65 purM were protected" ;
    rdfs:label "Burkholderia pseudomallei purM mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012175 .

obo:VO_0002828
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Although 30:93a purN -immunized mice were challenged with a 10-fold higher dose of WT E8, mice were strongly protected and showed no signs of clinical illness until the experiment was terminated" ;
    rdfs:label "Burkholderia pseudomallei purN mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012175 .

obo:VO_0002829
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A crp mutant is attenuated in zebrafish and catfish that were immunized intramuscularly and intracoelomically, respectively. Six weeks after immunization, both zebrafish and catfish were protected from challenge with wild type E. ictaluri" ;
    rdfs:label "E. ictaluri crp mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001521 .

obo:VO_0002830
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC mutant is attenuated in zebra fish. The aroC mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 68.3%" ;
    rdfs:label "Edwardsiella tarda aroC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002506 .

obo:VO_0002831
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC mutant is attenuated in zebra fish. The aroC mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 68.3%" ;
    rdfs:label "Edwardsiella tarda aroC/slyA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002506 .

obo:VO_0002832
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC mutant is attenuated in zebra fish. The aroC mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 68.3%" ;
    rdfs:label "Edwardsiella tarda aroC/esrC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002506 .

obo:VO_0002833
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An esrB mutant is highly attenuated in fish (turbot), with an LD50 of 10(8.1)cfu/fish. Vaccination with this mutant elicited significant protection from wild type E. tarda" ;
    rdfs:label "Edwardsiella tarda esrB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002506 .

obo:VO_0002834
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC and esrC mutant is attenuated in zebra fish. This mutant is also protective against challenge with wild type E. tarda and has a relative percent survival of 71.3%" ;
    rdfs:label "Edwardsiella tarda aroC/esrC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002506 .

obo:VO_0002835
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroC and slyA mutant is attenuated in zebra fish. This mutant is also protective against challenge from wild type E. tarda, resulting in a relative percent survival of 80.1%" ;
    rdfs:label "Edwardsiella tarda aroC/slyA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002506 .

obo:VO_0002836
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A carAB mutant is attenuated in turkeys and induces significant protection from challenge with wild type E. coli" ;
    rdfs:label "Escherichia coli carAB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000962 .

obo:VO_0002837
    obo:IAO_0000115 "A vaccine that prevents or treats an autoimmune disease." ;
    obo:IAO_0000117 "YH, RS" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/15196997" ;
    a owl:Class ;
    rdfs:label "autoimmune disease vaccine"@en ;
    rdfs:subClassOf obo:VO_0002813 .

obo:VO_0002838
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ler deletion mutant derived from wild-type EHEC O157:H7 86-24 was constructed by use of suicide vector pCVD442. Following challenge of 7-day-old suckling mice with O157:H7 EDL933, 75.2% born to group B mothers (immunized with F25) sur- vived, as did 83.0% born to group C mothers (immunized with F105). The surviving suckling mice consistently gained body weight. Only 16.8% of sucking mice born to control group mice survived the challenge" ;
    rdfs:label "Escherichia coli ler mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000962 .

obo:VO_0002839
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of waaL results in a strain that stimulates enhanced urothelial cytokine secretion, which is an enhanced innate immune response. Inoculation with the vaccine strain protected mice against challenge with a broad range of clinical uropathogenic E. coli isolates and produced immunity that lasted ⩾8 weeks" ;
    rdfs:label "Escherichia coli rfaL mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000962 .

obo:VO_0002840
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "There was a deletion in gene capB of F. tularensis live vaccine strain. LVS capB, while much less virulent than LVS, induces potent protective immunity against lethal LVS i.n. challenge in mice, comparable to that induced by LVS" ;
    rdfs:label "Francisella tularensis capB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002841
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A clpB mutant in Francisella tularensis subspecies tularensis strain SCHU S4 was attenuated and provided protection against aerosol challenge in mice" ;
    rdfs:label "Francisella tularensis clpB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002842
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A FTL0552 mutant in Francisella tularensis was attenuated and provided partial protection in mice against challenge with a lethal dose of the virulent SchuS4 strain when compared to naive mice" ;
    rdfs:label "Francisella tularensis FTL0552 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002843
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An FTT0918 mutant showed significantly reduced virulence in mice. Mice that recovered from infection with the mutant were protected 2 months later from challenge with wild type F. tularensis" ;
    rdfs:label "Francisella tularensis FTT0918 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002844
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A galU mutant is attenuated in mice, with only transient weight loss observed. Two months after inoculation, mice were challenge with wild type F. tularensis and were protected, once again only experiencing transient weight loss" ;
    rdfs:label "Francisella tularensis galU mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002845
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaA mutant is highly attenuated in mice and induces significant protection from challenge with parent strain F. tularensis LVS" ;
    rdfs:label "Francisella tularensis guaA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002846
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaB mutant is attenuated in mice and induces significant protection from challenge with parent strain F. tularensis LVS" ;
    rdfs:label "Francisella tularensis guaB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002847
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Intranasal vaccination with KKF235 (F. tularensis subsp. novicida mutant (DeltaiglB) ) protected mice from subsequent homotypic challenge with U112 as well as heterotypic challenge with F. tularensis subsp. holarctica (LVS). Most significantly, oral immunization with KKF235 protected mice from a highly lethal subsp. tularensis (SCHU S4) pulmonary challenge" ;
    rdfs:label "Francisella tularensis IglB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002848
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An iglC mutant is highly attenuated in mice. Inoculated mice were challenged 30 days later with wild type F. tularensis and were highly protected" ;
    rdfs:label "KKF24" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002849
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A purMCD mutant in Francisela tularensis was attenuated. A low dosage of F. tularensis LVS delta purMCD mutant provided protection against challenge in mice" ;
    rdfs:label "Francisella tularensis purMCD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002850
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mice, which had been immunized with at least 6.95×103 cfu of F. tularensis U112 purF::Cm, were protected against the subsequent F. tularensis subspecies novicida challenge" ;
    rdfs:label "Francisella tularensis purF mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002851
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A purMCD mutant in Francisella tularensis was attenuated. A low dose of the F. tularensis LVS delta purMCD mutant provided protection against subsequent lethal challenge with the LVS parental strain" ;
    rdfs:label "Francisella tularensis purMCD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002852
    obo:IAO_0000115 "A Streptococcus  vaccine against Streptococcus pyogenes infection." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Streptococcus pyogenes vaccine"@en ;
    rdfs:subClassOf obo:VO_0000772, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0002853
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A sodC mutant in Francisella tularensis subspecies holarctica was attenuated and provided protection and cleared the infection against lethal challenge in nearly 50% of the mice infected with the ΔsodC mutant" ;
    rdfs:label "Francisella tularensis sodC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002854
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A wbtA mutant in Francisella tularensis was attenuated and provided protection in mice against challenge with an otherwise lethal dose of either F. tularensis LVS or a fully virulent clinical isolate of F. tularensis type B" ;
    rdfs:label "Francisella tularensis wbtA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002855
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A wbtI mutant is attenuated in mice. The mutant protected against a low dose challenge with the parental strain, but was less effective against higher doses. However, increasing the immunization dose increased the resistance to higher challenge doses" ;
    rdfs:label "Francisella tularensis wbtI mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0002856
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in mice and induced significant protection after two doses from challenge with wild type M. haemolytica" ;
    rdfs:label "Mannheimia haemolytica aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001523 .

obo:VO_0002857
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lpd mutant is highly attenuated in chickens and induces significant protection from challenge with wild type M. gallisepticum" ;
    rdfs:label "Mycoplasma gallisepticum lpd mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000949 .

obo:VO_0002858
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A metH mutant, in combination with a siaD mutation, is attenuated in mice and induces significant protection from challenge with wild type N. meningitidis" ;
    rdfs:label "Neisseria meningitidis metH/siaD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0002859
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An rfaF mutant, in combination with a siaD mutation, is attenuated in mice and induces significant protection from challenge with wild type N. meningitidis" ;
    rdfs:label "Neisseria meningitidis rfaF/siaD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0002860
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A siaD mutant, in combination with either a metH or rfaF mutation, is attenuated in mice and induces protection from challenge with wild type N. meningitidis" ;
    rdfs:label "Neisseria meningitidis metH/siaD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0002861
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A siaD mutant, in combination with either a metH or rfaF mutation, is attenuated in mice and induces protection from challenge with wild type N. meningitidis" ;
    rdfs:label "Neisseria meningitidis rfaF/siaD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0002862
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in calves and induces significant protection from challenge with wild type P. multocida" ;
    rdfs:label "Pasteurella multocida aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0002863
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is attenuated in mice and induced significant protection from challenge with wild type S. typhi Ty2" ;
    rdfs:label "Salmonella typhi aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000671 .

obo:VO_0002864
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of AroC results in attenuation in humans, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain \"CVD 908\"" ;
    rdfs:label "Aro-deleted S. Typhi" ;
    rdfs:subClassOf obo:VO_0000671 .

obo:VO_0002865
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of AroC results in attenuation in humans, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain \"CVD 908\"" ;
    rdfs:label "CVD 908-htrA" ;
    rdfs:subClassOf obo:VO_0000671 .

obo:VO_0002866
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Inactivation of AroD results in attenuation in humans, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain \"CVD 908\"" ;
    rdfs:label "Aro-deleted S. Typhi" ;
    rdfs:subClassOf obo:VO_0000671 .

obo:VO_0002867
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An asd mutant, alone or in combination with a rfc mutation, is attenuated in mice and induces significant protection from challenge with wild type Salmonella typhimurium" ;
    rdfs:label "Salmonella Typhimurium asd mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002868
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An asd mutant, alone or in combination with a rfc mutation, is attenuated in mice and induces significant protection from challenge with wild type Salmonella typhimurium" ;
    rdfs:label "Salmonella Typhimurium asd/rfc mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002869
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An atpA mutant is attenuated in mice and induces significant protection from challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium atpA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002870
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cbiA mutant, in combination with a cobS mutation, is attenuated in chickens and induces significant protection from challenge with wild type S. Gallinarum. This mutant was also able to provide some protection against S. Enteritidis" ;
    rdfs:label "Salmonella Gallinarum cbiA/cobS mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002871
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1941) is attenuated in mice after oral immunization. This mutant is also protective, and had a vaccine efficacy of 76% against challenge with wild type Salmonella Enteritidis" ;
    rdfs:label "Salmonella Enteritidis guaBA/clpP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002509 .

obo:VO_0002872
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in clpP (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice, and an LD50 for CS2007 could not be determined because mice did not die after inoculation with the highest dose. CS2007 also elicited protection in mice from challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium clpP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002873
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in clpP (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice, and an LD50 for CS2007 could not be determined because mice did not die after inoculation with the highest dose. CS2007 also elicited protection in mice from challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium guaBA/clpP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002874
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in clpP (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice, and an LD50 for CS2007 could not be determined because mice did not die after inoculation with the highest dose. CS2007 also elicited protection in mice from challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium guaBA/clpP/fliD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002875
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cobS mutant, in combination with a cbiA mutation, is attenuated in chickens and induces significant protection from challenge with wild type S. Gallinarum. This mutant was also able to provide some protection against S. Enteritidis" ;
    rdfs:label "Salmonella Gallinarum cbiA/cobS mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002876
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs" ;
    rdfs:label "Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002877
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cpxR mutant, in combination with a lon mutation, is highly attenuated in mice and induces significant protection from challenge with wild type S. gallinarum" ;
    rdfs:label "Salmonella Gallinarum cpxR/Ion mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002878
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cya and crp mutant is attenuated in mice. Thirty days after immunization, mice were protected from oral challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium cya/crp mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002879
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A crp mutant is attenuated in mice and induces significant protection from challenge with wild type S. gallinarum" ;
    rdfs:label "Salmonella Gallinarum crp mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002880
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cya and crp mutant is attenuated in mice. Thirty days after immunization, mice were protected from oral challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium cya/crp mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002881
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A fliC mutant, in combination with a guaB mutant, is attenuated in mice and chickens and induces significant protection from challenge with wild type S. enterica" ;
    rdfs:label "Salmonella enterica fliC/guaB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002509 .

obo:VO_0002882
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA, clpP, and fliD mutant (CVD 1923) is attenuated in mice after oral immunization. This mutant is also protective, with a vaccine efficacy of 80% in mice against wild type challenge from Salmonella Typhimurium" ;
    rdfs:label "Salmonella Typhimurium guaBA/clpP/fliD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002883
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gal E mutant in strain Ty2 was isolated, attenuated, and protected mice against lethal challenge" ;
    rdfs:label "Salmonella Typhi galE mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000671 .

obo:VO_0002884
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1941) is attenuated in mice after oral immunization. This mutant is also protective in mice and had a vaccine efficacy of 76% against challenge with wild type Salmonella Enteritidis" ;
    rdfs:label "Salmonella Enteritidis guaBA/clpP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002509 .

obo:VO_0002885
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "Salmonella Typhimurium guaBA/clpP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002886
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "Salmonella Typhimurium guaBA/clpP/fliD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002887
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "Salmonella Typhimurium guaBA/clpP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002888
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium" ;
    rdfs:label "Salmonella Typhimurium guaBA/clpP/fliD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002889
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaB mutant, in combination with a fliC mutant, is attenuated in mice and chickens and induced significant protection from challenge with wild type S. enterica" ;
    rdfs:label "Salmonella enterica fliC/guaB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002509 .

obo:VO_0002890
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaB mutant, in combination with a fliC mutant, is attenuated in mice and chickens and induced significant protection from challenge with wild type S. enterica" ;
    rdfs:label "Salmonella Enteritidis guaBA/clpP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002509 .

obo:VO_0002891
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs" ;
    rdfs:label "Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002892
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Oral immunization with the Salmonella hfq deletion mutant efficiently protects mice against subsequent oral challenge with virulent strain of Salmonella Typhimurium" ;
    rdfs:label "Salmonella Typhimurium hfq mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002893
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A htrA mutant in Salmonella typhimurium is attenuated and provides protection in mice against an oral challenge with virulent S. typhimurium SL1344" ;
    rdfs:label "Salmonella Typhimurium htrA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002894
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A lon mutant, in combination with a cpxR mutation, is highly attenuated in mice and induces significant protection from challenge with wild type S. gallinarum" ;
    rdfs:label "Salmonella Gallinarum cpxR/Ion mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002895
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lppA mutant, in combination with an lppB/msbB mutation, is attenuated in mice and induces significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium IppA/IppB/msbB" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002896
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lppB mutant, in combination with an msbB mutant or an msbB/lppA mutant, is attenuated in mice and induces significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium IppA/IppB/msbB" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002897
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An lppB mutant, in combination with an msbB mutant or an msbB/lppA mutant, is attenuated in mice and induces significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium IppB/msbB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002898
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An msbB mutant, in combination with an lppB or lppAB mutation, is attenuated in mice and induces significant protection from challenge with S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium IppA/IppB/msbB" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002899
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An msbB mutant, in combination with an lppB or lppAB mutation, is attenuated in mice and induces significant protection from challenge with S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium IppB/msbB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002900
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "In a pig infection experiment including two oral immunizations with SalmoporcDeltaompD (OmpD, nmpC) and challenge with a multiresistant S. enterica serovar Typhimurium DT104 clinical isolate, we confirmed the protective efficacy of SalmoporcDeltaompD in pigs, showing a significant reduction of both clinical symptoms and colonization of lymph nodes and intestinal tract" ;
    rdfs:label "Salmonella Typhimurium ompD/nmpC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002901
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A nuoG mutant is attenuated in chickens and induced significant protection from challenge with wild type S. Gallinarum" ;
    rdfs:label "Salmonella Gallinarum nuoG mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002902
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An ompR mutant is attenuated in mice after oral challenge. Twenty eight days after immunization, mice were challenged with wild type S. typhimurium and were significantly protected" ;
    rdfs:label "Salmonella Typhimurium ompR mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002903
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Three S. typhi deletion mutants (phoP, rpoS, and rpoS-phoP double mutant) were constructed and characterized with respect to invasiveness, virulence, and protective immune response compared with wild-type Ty2. All S. typhi mutants showed an increase in the specific serum IgG levels and T-cell-mediated immunity, and showed equal protection abilities against a wild-type Ty2 challenge after two rounds of immunization in BALB/c mice" ;
    rdfs:label "Salmonella Typhi phoP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000671 .

obo:VO_0002904
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A poxA mutant is attenuated in mice and induces significant protection from challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium poxA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002905
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ppGpp-defective Salmonella Gallinarum, which is attained by mutating the relA and spoT genes, is attenuated in chickens and induces protection from oral challenge with wild type S. Gallinarum" ;
    rdfs:label "Salmonella Gallinarum relA/spoT mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002906
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An rfc mutant, in combination with an asd mutation, is attenuated in mice and induces significant protection from challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium asd/rfc mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002907
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs" ;
    rdfs:label "Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002908
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Immunizations with Salmonella typhimurium rpoS and rpoS aroA mutants protected susceptible BALB/c mice against subsequent oral challenge with virulent S. typhimurium. When administered orally or intraperitoneally, rpoS derivatives of the mouse-virulent S. typhimurium strains, C52 and SL1344, were highly attenuated and were efficient single-dose live vaccines" ;
    rdfs:label "Salmonella Typhimurium rpoS mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002909
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ruvB mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium ruvB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002910
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ppGpp-defective Salmonella Gallinarum, which is attained by mutating the relA and spoT genes, is attenuated in chickens and induces protection from oral challenge with wild type S. Gallinarum" ;
    rdfs:label "Salmonella Gallinarum relA/spoT mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002508 .

obo:VO_0002911
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A surA mutant (BRD1115) is attenuated in BALB/c mice and induces protection from challenge with wild type S. typhimurium" ;
    rdfs:label "Salmonella Typhimurium surA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002912
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A tolA mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium tolA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002913
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A trxA mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium" ;
    rdfs:label "Salmonella Typhimurium trxA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002914
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A wecA mutant (DSM645) is attenuated in C57BL/6J mice through i.p. and oral immunization. This mutant also protects against challenge with S. typhimurium strains TML and SL1344 30 days after immunization" ;
    rdfs:label "Salmonella Typhimurium wecA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002915
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A znuABC mutant is attenuated in mice and induced significant protection against a challenge infection in the large intestine with wild type Salmonella typhimurium" ;
    rdfs:label "Salmonella Typhimurium znuABC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002916
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A znuABC mutant is attenuated in mice and induced significant protection against a challenge infection in the large intestine with wild type Salmonella typhimurium" ;
    rdfs:label "Salmonella Typhimurium znuABC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002917
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A znuABC mutant is attenuated in mice and induced significant protection against a challenge infection in the large intestine with wild type Salmonella typhimurium" ;
    rdfs:label "Salmonella Typhimurium znuABC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002507 .

obo:VO_0002918
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "CVD 1204(pGA1-CS2)" ;
    rdfs:subClassOf obo:VO_0000769 .

obo:VO_0002919
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "S. dysenteriae 1 strain WRSd1" ;
    rdfs:subClassOf obo:VO_0000681 .

obo:VO_0002920
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "S. flexneri 2a strain CVD 1203" ;
    rdfs:subClassOf obo:VO_0000680 .

obo:VO_0002921
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "S. sonnei strain WRSS1" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002922
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroD mutant is highly attenuated in monkeys and induces significant protection from challenge with wild type S. flexneri" ;
    rdfs:label "S. flexneri strain Sfl 124" ;
    rdfs:subClassOf obo:VO_0000680 .

obo:VO_0002923
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroD mutant is highly attenuated in monkeys and induces significant protection from challenge with wild type S. flexneri" ;
    rdfs:label "Shigella flexneri aroD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000680 .

obo:VO_0002924
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An envZ mutant (SC433) is greatly decreased in virulence in macaque monkeys, though some mild clinical signs were still recorded. This mutant is also highly protective against a challenge of wild type S. flexneri delivered 1 month after inoculation" ;
    rdfs:label "Shigella flexneri envZ mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000680 .

obo:VO_0002925
    obo:IAO_0000115 "a Brucella vaccine against infection wtih B. ovis" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Brucella ovis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000025, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_236
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_236
    ] .

obo:VO_0002926
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA and virG mutant (CVD 1203) is attenuated in guinea pigs, as shown by the Sereny test. Guinea pigs inoculated with CVD 1203 were also protected from challenge with wild type S. flexneri" ;
    rdfs:label "SC602" ;
    rdfs:subClassOf obo:VO_0000769 .

obo:VO_0002927
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, senB, and msbB2 mutant (WRSs3) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs3 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "Shigella sonnei virG/senA/senB/msbB2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002928
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "Shigella sonnei virG/senA/senB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002929
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "Shigella sonnei virG/senA/senB/msbB2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002930
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "Shigella sonnei virG/senA/senB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002931
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG, senA, and senB mutant (WRSs2) is attenuated in guinea pigs and induced significant protection from challenge with wild type S. sonnei. Attenuation and protection from WRSs2 is comparable to live attenuated vaccine strain WRSS1" ;
    rdfs:label "Shigella sonnei virG/senA/senB/msbB2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002932
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG mutant (WRSS1) is attenuated in guinea pigs and induced significant protection from challenge with wild type Shigella sonnei" ;
    rdfs:label "Shigella sonnei virG/senA/senB mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002933
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virG mutant (WRSS1) is attenuated in guinea pigs and induced significant protection from challenge with wild type Shigella sonnei" ;
    rdfs:label "Shigella sonnei virG/senA/senB/msbB2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000679 .

obo:VO_0002934
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A hemA mutant is highly attenuated in mice and rabbits and induces protection from challenge with wild type V. cholerae in rabbits" ;
    rdfs:label "Vibrio cholerae hemA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000763 .

obo:VO_0002935
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in mice, and after 3 doses induces significant protection from challenge with wild type Y. enterocolitica" ;
    rdfs:label "Yersinia enterocolitica aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012186 .

obo:VO_0002936
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A htrA mutant in Yersinia enterocolitica was attenuated and provided partial protection against challenge in mice" ;
    rdfs:label "Yersinia enterocolitica htrA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012186 .

obo:VO_0002937
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A ompR mutant in Yersinia enterocolitica was attenuated and provided a partial protection from challenge in mice" ;
    rdfs:label "Yersinia enterocolitica ompR mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012186 .

obo:VO_0002938
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A sodA mutant in Yersinia enterocolitica was highly attenuated and mice immunized with a single oral dose of the mutant strain were protected against a lethal oral-challenge infection with wild-type Y. enterocolitica" ;
    rdfs:label "Yersinia enterocolitica sodA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012186 .

obo:VO_0002939
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA mutant is attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "Yersinia pestis guaBA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002940
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A guaBA mutant is attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "Yersinia pestis guaBA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002941
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An IpxM mutant is attenuated in mice and guinea pigs. This mutant also conferred modest protection from challenge with wild type Y. pestis in Balb/c mice and significant protection in guinea pigs and outbred mice" ;
    rdfs:label "Yersinia pestis IpxM mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002942
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An nlpD mutant is highly attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "Yersinia pestis nlpD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002943
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A pcm mutant is highly attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "Yersinia pestis pcm mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002944
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An smpB mutant, in combination with an ssrA mutation, is attenuated in mice and induces significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "Yersinia pestis smpB/ssrA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002945
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An smpB mutant, in combination with an ssrA mutation, is attenuated in mice and induces significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "Yersinia pestis smpB/ssrA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002946
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A yopH mutant is highly attenuated in mice and induced significant protection from challenge with wild type Y. pestis" ;
    rdfs:label "Yersinia pestis yopH mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000648 .

obo:VO_0002947
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A phoP mutant in Yersinia pseudotuberculosis (Yptb) was attenuated and provided protection against oral challenge with virulent Yptb in mice" ;
    rdfs:label "Yersinia pseudotuberculosis phoP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002510 .

obo:VO_0002948
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An aroA mutant is highly attenuated in rainbow trout and induces significant protection from challenge with wild type Y. ruckeri" ;
    rdfs:label "Yersinia ruckeri aroA mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001035 .

obo:VO_0002949
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient mutant (B8-D53) showed no detectable thymidine kinase-inducing activity and was attenuated in calves. B8-D53 also induced protection from challenge with wild type BHV-1" ;
    rdfs:label "Bovine herpesvirus 1 UL23 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001482 .

obo:VO_0002950
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A deletion of BHV-1 gE gene in strain A is considered as a live attenuated vaccine. After challenge, vaccinated calves were protected against disease and virus shedding was reduced" ;
    rdfs:label "Bovine herpesvirus 1 US8 (gE) mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001482 .

obo:VO_0002951
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein G deletion in bovine respiratory syncytial virus(rBRSV) and recombinant rBRSV was attenuated and provided protection against a BRSV challenge infection in calves" ;
    rdfs:label "Bovine respiratory syncytial virus glycoprotein G mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001507 .

obo:VO_0002952
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An N269A/Q mutation in the E(rns) protein created an attenuated mutant in swine. This mutant was able to induce effective protection in swine against challenge with wild type CSFV" ;
    rdfs:label "Classical swine fever virus E(rns) mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001012 .

obo:VO_0002953
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An N to A amino acid substitution was made in the N594 site of the E1 glycoprotein, resulting in attenuation of the virus in swine. This attenuated virus induced protection against challenge with wild type CSFV" ;
    rdfs:label "Classical swine fever virus E1 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001012 .

obo:VO_0002954
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A E2 mutant in Classical swine fever virus is attenuated and provides protection in pigs after oronasal vaccination (not intradermal vaccination) against lethal challenge dose of CSFV strain Eystrup" ;
    rdfs:label "Classical swine fever virus E2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001012 .

obo:VO_0002955
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein E mutant is attenuated in mice and hamsters and induced significant protection from challenge with wild type Equid herpesvirus in mice" ;
    rdfs:label "Equid herpesvirus gE mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001486 .

obo:VO_0002956
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein I mutant is attenuated in mice and hamsters and induced significant protection from challenge with wild type Equid herpesvirus in mice" ;
    rdfs:label "Equid herpesvirus gI mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001486 .

obo:VO_0002957
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient mutant (PR1) is attenuated in mice and induced significant protection from challenge with wild type EHV-1 5 weeks after vaccination. In foals, PR1 also showed attenuation; however, the mutant induced only partial protection from challenge with EHV-1" ;
    rdfs:label "Equid herpesvirus TK mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001486 .

obo:VO_0002958
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient mutant (C7301dlTK) is attenuated in cats and induced significant protection from wild type FHV-1 4 weeks after vaccination" ;
    rdfs:label "Feline herpesvirus 1 UL23 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001487 .

obo:VO_0002959
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Feline immunodeficiency virus (FIV) made defective in the accessory gene ORF-A were previously shown to be greatly attenuated in its ability to replicate in lymphocytes but to grow normally or near normally in other cell types. 3/9 vaccinees (cats) showed no evidence of the challenge virus over a 15-month observation period. In the other vaccinees, the challenge virus was predominant for various periods of time, but pre-existing viral loads and CD4 lymphocyte counts were either unaffected or altered only marginally and transiently" ;
    rdfs:label "Feline immunodeficiency virus ORF-A mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001508 .

obo:VO_0002960
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A vif mutant in feline immunodeficiency virus was attenuated and FIV-pPPRΔvif proviral DNA protected cats against challenge with the homologous FIV-PPR biological isolate." ;
    rdfs:label "Feline immunodeficiency virus vif mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001508 .

obo:VO_0002961
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "Feline infectiour peritonitis virus 3abc mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001504 .

obo:VO_0002962
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "Feline infectiour peritonitis virus 3abc mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001504 .

obo:VO_0002963
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "Feline infectiour peritonitis virus 3abc mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001504 .

obo:VO_0002964
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 7ab deletion mutant in Feline infectious peritonitis virus is attenuated and provides protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "Feline infectious peritonitis virus 7ab mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001504 .

obo:VO_0002965
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A 7ab deletion mutant in Feline infectious peritonitis virus is attenuated and provides protection against virulent FIPV strain 79-1146 challenge in kittens" ;
    rdfs:label "Feline infectious peritonitis virus 7ab mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001504 .

obo:VO_0002966
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL0 mutant in infectious laryngotracheitis virus (ILTV) was attenuated. Chickens immunized with UL0-negative ILTV were protected from clinical disease after subsequent infection with virulent ILTV" ;
    rdfs:label "Gallid herpesvirus 1 UL0 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001488 .

obo:VO_0002967
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine-kinase mutant is attenuated in chickens and induced protection from challenge with wild type GHV-1" ;
    rdfs:label "Gallid herpesvirus 1 UL23 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001488 .

obo:VO_0002968
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL47 mutant in avian infectious laryngotracheitis virus is attenuated and provides protection in chicken against subsequent challenge infection with virulent ILTV" ;
    rdfs:label "Gallid herpesvirus 1 UL47 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001488 .

obo:VO_0002969
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Researchers generated a series of woodchuck hepatitis virus (WHV) X mutants. Woodchucks inoculated with X mutants, including those with no serologic evidence of infection, were protected from later challenge with infectious Woodchuck Hepatitis Virus, suggesting previous infection with resulting protective immunity" ;
    rdfs:label "Hepatitis B virus X protein mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000644 .

obo:VO_0002970
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "KOS-gDA3C is attenuated with mutations in gD gene in causing skin lesions at the inoculation and zosteriform sites, yet it is as effective as rKOS-gDA3C in protecting mice against HSV-1 challenge" ;
    rdfs:label "Herpes simplex virus 1 gD mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000958 .

obo:VO_0002971
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gH mutant is attenuated in mice and induces significant protection from challenge with wild type HSV-1" ;
    rdfs:label "Herpes simplex virus 1 gH mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000958 .

obo:VO_0002972
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A live-attenuated HSV-2 ICP0 virus provides significant protection against wild-type HSV-2 (MS strain) challenge in mice" ;
    rdfs:label "Herpes simplex virus 2 ICP0 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012168 .

obo:VO_0002973
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A thymidine kinase-deficient (TK) mutant was found to be attenuated in mice. This mutant induced complete protection from challenge with wild type HSV" ;
    rdfs:label "Herpes simplex virus 1 TK mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000958 .

obo:VO_0002974
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL29 mutant is attenuated in mice and induces significant protection from challenge with wild type HSV-1" ;
    rdfs:label "Herpes simplex virus 1 UL29 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000958 .

obo:VO_0002975
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An HSV-1 gE (Us8) deletion strain, NS-gEnull, was used as a live attenuated vaccine. After HSV-1 challenge, latent virus was recovered by DRG explant cocultures from <10% of vaccinated mice compared with 100% of mock-vaccinated mice" ;
    rdfs:label "Herpes simplex virus type 1 DNA vaccine encoding GE" ;
    rdfs:subClassOf obo:VO_0000958 .

obo:VO_0002976
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A G mutant is attenuated in African green monkeys and induces protection from challenge with wild type HMPV" ;
    rdfs:label "Human metapneumovirus G protein mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002511 .

obo:VO_0002977
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An M2-2 mutant is attenuated in African green monkeys and induced protection from challenge with wild type HMPV" ;
    rdfs:label "Human metapneumovirus M2-2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002511 .

obo:VO_0002978
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An M2-2 mutant of human respiratory syncytial virus A2 is attenuated in African green monkeys. When challenged with wild type RSV, two doses provided complete protection against challenge in the lower respiratory tract and a significant reduction of the challenge virus in the upper respiratory tract" ;
    rdfs:label "Human Respiratory Syncytial Virus M2-2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002512 .

obo:VO_0002979
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in the non-virion protein of IHNV causes attenuated growth in rainbow trout and is able to provide significant protection from subsequent challenge with wild type IHNV" ;
    rdfs:label "Infectious Hematopoietic Necrosis Virus NV mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012165 .

obo:VO_0002980
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Mutant influenza virus that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) from Influenza A virus (A/Puerto Rico/8/34(H1N1)) is attenuated in both cell culture and mice. Mice intranasally vaccinated with M2KO virus developed protective immune responses and survived a lethal challenge with the wild-type virus, suggesting that the M2KO virus has potential as a live attenuated vaccine" ;
    rdfs:label "Influenza virus CTA1-3M2e-DD protein vaccine" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0002981
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Intranasal inoculation of mice, pigs, horses, and macaques with NS1-modified influenza virus strains induced robust humoral and cellular immune responses, and generated immune protection against challenge with wild-type virus" ;
    rdfs:label "Influenza virus NS1 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0002982
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mutation in the GP5 protein attenuates HP-PRRSV in piglets. This mutant (HuN4-F112) induces protection against challenge with wild type HP-PRRSV" ;
    rdfs:label "Porcine respiratory and reproductive syndrome virus GP5 protein mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001511 .

obo:VO_0002983
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein E mutant, in combination with UL23 and glycoprotein G mutations, is attenuated in raccoons, with a 75% survival rate. This mutant also provides some protection from wild type PRV" ;
    rdfs:label "Pseudorabies virus glycoprotein E/G/UL23 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002984
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein G mutant, in combination with UL23 and glycoprotein E mutations, is attenuated in raccoons, with a 75% survival rate. This mutant also provides some protection from wild type PRV" ;
    rdfs:label "Pseudorabies virus glycoprotein E/G/UL23 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002985
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein M, gM, deletion in pseudorabies virus was attenuated and induced protection in piglets against intranasal challenge with 108 p.f.u. of the highly virulent PrV strain NIA-3" ;
    rdfs:label "Psuedorabies virus glycoprotein M mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002986
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gp50+gp63 deletion mutant in Pseudorabies virus was attenuated and provided protection from clinical signs of Aujeszky's disease after a challenge inoculation with the virulent wild-type PRV strain NIA-3" ;
    rdfs:label "Pseudorabies virus gp50/gp63 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002987
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A gp50+gp63 deletion mutant in Pseudorabies virus was attenuated and provided protection from clinical signs of Aujeszky's disease after a challenge inoculation with the virulent wild-type PRV strain NIA-3" ;
    rdfs:label "Pseudorabies virus gp50/gp63 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002988
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL23 mutant, in combination with mutations in glycoproteins G and E, is attenuated in raccoons, with a 75% survival rate. This mutant also provides some protection from wild type PRV" ;
    rdfs:label "Pseudorabies virus glycoprotein E/G/UL23 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002989
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UL50 mutant is attenuated in pseudorabies virus and induces significant protection in pigs from challenge with the highly virulent NIA-3 strain of PrV" ;
    rdfs:label "Pseudorabies virus UL50 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002990
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Researchers intranasally inoculated pigs, the natural host of this virus, with mutant PRV strains in which the genes encoding the protein kinase (US3) proteins were inactivated. After challenge infection with the virulent PRV strain NIA-3, no virus was excreted by wt PRV- and PK- mutant-immunized animals, indicating complete protective immunity" ;
    rdfs:label "Pseudorabies virus US3 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000750 .

obo:VO_0002991
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A glycoprotein G mutant in rabies virus is attenuated. After a one-dose intramuscular vaccination, the ERAg3m virus protected 100% of mice and hamsters from lethal challenge. In co-infections, using a lethal dose of street rabies virus mixed with ERAg3m, 100% of hamsters and 90% of mice survived and were protected against subsequent infection" ;
    rdfs:label "Rabies virus glycoprotein G mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000650 .

obo:VO_0002992
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A P gene mutant is attenuated in mice and induces significant protection from challenge with wild type Rabies virus" ;
    rdfs:label "Rabies virus P protein mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000650 .

obo:VO_0002993
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An E mutant is attenuated in hamsters and induces significant protection from challenge with wild type SARS" ;
    rdfs:label "SARS-CoV E gene mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0002994
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A SIV nef mutant is attenuated in rhesus monkeys and induces protection from challenge with wild type SIV" ;
    rdfs:label "Simian Immunodeficiency Virus nef mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000751 .

obo:VO_0002995
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virus with a mutation in protein C is attenuated in mice and induced protection from challenge with wild type TBE virus" ;
    rdfs:label "ick-borne Encephalitis Virus C protein mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012190 .

obo:VO_0002996
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A VEE mutant with a PE2 cleavage signal mutation and a suppressor mutation in E1 is highly attenuated in mice and provides complete protection against challenge with wild type VEE" ;
    rdfs:label "VEE Virus PE2/E1 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001499 .

obo:VO_0002997
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A VEE mutant with a PE2 cleavage signal mutation and a suppressor mutation in E1 is highly attenuated in mice and provides complete protection against challenge with wild type VEE" ;
    rdfs:label "VEE Virus PE2/E1 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001499 .

obo:VO_0002998
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A virus with a C protein mutation is attenuated in mice and induces significant protection from challenge with wild type West Nile virus" ;
    rdfs:label "West Nile virus C protein mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000752 .

obo:VO_0002999
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "WEEV DNA Vaccine encoding 6K-E1 Protein" ;
    rdfs:subClassOf obo:VO_0012188 .

obo:VO_0003000
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "Western equine encephalomyelitis virus PE2/E1 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012188 .

obo:VO_0003001
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E2 (WE2102) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "WEEV Subunit E2 Protein Vaccine" ;
    rdfs:subClassOf obo:VO_0012188 .

obo:VO_0003002
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with a deletion in E2 (WE2102) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of this strain would occur" ;
    rdfs:label "Western equine encephalomyelitis virus PE2/E2 mutant virus" ;
    rdfs:subClassOf obo:VO_0012188 .

obo:VO_0003003
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with either a deletion in E2 (WE2102) or E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of these two strains would occur" ;
    rdfs:label "Western equine encephalomyelitis virus PE2/E1 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012188 .

obo:VO_0003004
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A PE2 mutant combined with either a deletion in E2 (WE2102) or E1 (WE2130) induced low-level viremia in chickens and protected against challenge with wild type WEE after 2 weeks. This study also found that it is unlikely that mosquito transmission of these two strains would occur" ;
    rdfs:label "Western equine encephalomyelitis virus PE2/E2 mutant virus" ;
    rdfs:subClassOf obo:VO_0012188 .

obo:VO_0003005
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A cen1 mutant is attenuated in mice and hamsters and induces significant protection from challenge with wild type L. donovani" ;
    rdfs:label "Leishmania donovani cen1 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0001142 .

obo:VO_0003006
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A Leishmania infantum deletion mutant of HSP70-II gene is attenuated and provides protection against Leishmania infection in the L. major-BALB/c infection model. Also, DeltaHSP70-II is a safe live vaccine as immunodeficient SCID mice, and hamsters, infected with mutant parasites did not develp any sign of pathology" ;
    rdfs:label "Leishmania infantum HSP70 II mutant vaccine" ;
    rdfs:subClassOf obo:VO_0012159 .

obo:VO_0003007
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A genetically attenuated parasite (GAP) with a mutation in the FabB/FabF gene is attenuated in mice by arresting in the late liver stage. It also conferred complete protection in mice from challenge with wild type Plasmodium" ;
    rdfs:label "Plasmodium FabB/FabF mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000087 .

obo:VO_0003008
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Genetically attenuated P36p-deficient Plasmodium berghei sporozoites provide protection against sporozoites challenge in mice" ;
    rdfs:label "P. berghei p36p mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002513 .

obo:VO_0003009
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice. Mice immunized with the mutant were completely protected against challenge with wild type Plasmodium sporozoites" ;
    rdfs:label "P. yoelii p36/p52 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002514 .

obo:VO_0003010
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A genetically attenuated parasite (GAP) with deletions in p52 and p36 are attenuated in mice. Mice immunized with the mutant were completely protected against challenge with wild type Plasmodium sporozoites" ;
    rdfs:label "P. yoelii p36/p52 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002514 .

obo:VO_0003011
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Deletion of UIS3 in Plasmodium yoelii provided attenuation and full protection in mice by Pyuis3(-) sporozoites required at least 2 immunizations against challenges with infectious sporozoites" ;
    rdfs:label "P. yoelii UIS3 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0002514 .

obo:VO_0003012
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A mic2 mutant is attenuated in mice and induces protection from challenge with wild type T. gondii" ;
    rdfs:label "Toxoplasma gondii mic2 mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000994 .

obo:VO_0003013
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An OMPDC mutant, alone or in combination with an UP mutation, is attenuated in mice and induces significant protection from challenge with wild type T. gondii" ;
    rdfs:label "Toxoplasma gondii OMPDC mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000994 .

obo:VO_0003014
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "An OMPDC mutant, alone or in combination with an UP mutation, is attenuated in mice and induces significant protection from challenge with wild type T. gondii" ;
    rdfs:label "Toxoplasma gondii OMPDC/UP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000994 .

obo:VO_0003015
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "A UP mutant, in combination with an OMPDC mutation, is attenuated in mice and induces significant protection from wild type T. gondii" ;
    rdfs:label "Toxoplasma gondii OMPDC/UP mutant vaccine" ;
    rdfs:subClassOf obo:VO_0000994 .

obo:VO_0003016
    obo:IAO_0000115 "route of administration that located in the stomach, so that the material is taken into body through stomach directly. " ;
    dc:creator "YL" ;
    oboInOwl:hasSynonym "I.G." ;
    a owl:Class ;
    rdfs:label "intragastric route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0000945
    ] .

obo:VO_0003017
    obo:IAO_0000115 "a intragastric route that has a vaccine injection site located in stomach." ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "intragastric injection route" ;
    rdfs:subClassOf obo:VO_0003016, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:VO_0000335
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0001025 ;
                    owl:someValuesFrom obo:UBERON_0000945
                ]
            )
        ]
    ] .

obo:VO_0003018
    obo:IAO_0000115 "vaccination that occurs in the intagastric route." ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "intragastric vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0003016
    ] .

obo:VO_0003019
    dc:creator "YL", "vaccination process that occurs in intradermal route." ;
    a owl:Class ;
    rdfs:label "intradermal vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000887
    ] .

obo:VO_0003020
    obo:IAO_0000115 "vaccination process that occurs in intranasal route" ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "intranasal vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000341
    ] .

obo:VO_0003021
    obo:IAO_0000115 "vaccination process that occurs in oral route." ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "oral vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000886
    ] .

obo:VO_0003022
    obo:IAO_0000115 "vaccination process that occurs in the subcutaneous route" ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "subcutaneous vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0000532
    ] .

obo:VO_0003023
    obo:IAO_0000115 "a vaccine prepration process that mixes vaccine lyophilized powder and diluent liquid. The process forms a vaccine that can be used for administration. This term can also be considered as a child term of OBI term 'material combination'. " ;
    obo:IAO_0000119 "WEB: http://www.thehaiticonnection.org/medical/reconstitution.pdf" ;
    dc:creator "YL, YH" ;
    a owl:Class ;
    rdfs:comment """A vaccine may include vaccine powder and solvent. When the two mix, we get a vaccine solution, which can be used to inject. Examples:
http://www.medicines.org.uk/guides/acwy%20vax/Vaccinations%20%28all%29/
http://www.medicines.org.uk/guides/menitorix/Vaccinations%20%28all%29/ 
http://www.medicines.org.uk/guides/priorix/Vaccinations%20%28all%29/ """, "Use only the specific diluent provided by the manufacturer for each type of vaccine to ensure adequate potency and safety of the resulting mixture." ;
    rdfs:label "vaccine reconstitution" ;
    rdfs:subClassOf [
        a owl:Class ;
        owl:intersectionOf (obo:OBI_0000652
            obo:VO_0000590
        )
    ] .

obo:VO_0003024
    obo:IAO_0000115 "a vaccine powder that is freeze-dried and lyophilized. " ;
    dc:creator "YL,YH" ;
    a owl:Class ;
    rdfs:label "lyophilized vaccine powder" ;
    rdfs:subClassOf obo:VO_0000228 .

obo:VO_0003025
    obo:IAO_0000115 "a role inheres in the vaccine component when it is added into vaccine's formulation, it tends to stabilizes an emulsion by increasing its kinetic stablity."@en ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "vaccine emulsifier role" ;
    rdfs:subClassOf obo:VO_0000415 .

obo:VO_0003026
    obo:IAO_0000115 "a role inheres in vaccine component when added into vaccine's formulation, it tends to inhibit the reaction between two or more other vaccine substances in the final vaccine formulation; it also helps to protect the vaccine from adverse conditions such as the freeze-drying process or heat."@en ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "vaccine stabilizer role" ;
    rdfs:subClassOf obo:VO_0000415 .

obo:VO_0003027
    obo:IAO_0000115 "a protein vaccine stablizer that is specifically human serum albumin." ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "human serum albumin vaccine additive" ;
    rdfs:subClassOf obo:VO_0003038, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003028
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0003026
    ] .

obo:VO_0003028
    obo:IAO_0000115 "the serum albumin that is part of human" ;
    obo:IAO_0000116 "it is subclass of 'serum albumin (PR:000003918)'" ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "human serum albumin" ;
    rdfs:seeAlso "UniProtKB:P02768" ;
    rdfs:subClassOf obo:VO_0000516 .

obo:VO_0003029
    obo:IAO_0000115 "a vaccine stabilizer that is gelatin." ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "gelatin vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0000853, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003030
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0003026
    ] .

obo:VO_0003030
    obo:IAO_0000117 "Gelatin is a mixture of peptides and proteins produced by partial hydrolysis of collagen extracted from the skin, boiled crushed bones, connective tissues, organs and some intestines of animals such as domesticated cattle, chicken, and pigs.(wikipedia)", "YL" ;
    a owl:Class ;
    rdfs:label "gelatin" ;
    rdfs:subClassOf obo:BFO_0000040 .

obo:VO_0003031
    obo:IAO_0000115 "a vaccine-induced host gene response that represents a vaccine adverse event response associated with a host susceptibility gene." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000118 "host susceptibility gene response to VAE" ;
    a owl:Class ;
    rdfs:label "host susceptibility gene response to vaccine adverse event"@en ;
    rdfs:subClassOf obo:VO_0000286 .

obo:VO_0003032
    a owl:Class ;
    rdfs:label "host immune factor-induced control of intracellular replication of live attenuated vaccine"@en ;
    rdfs:subClassOf obo:VO_0000286 .

obo:VO_0003033
    obo:IAO_0000115 "a protein vaccine stablizer that is specifically bovine serum albumin. " ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "bovine serum albumin vaccine additive" ;
    rdfs:subClassOf obo:VO_0003038 .

obo:VO_0003034
    obo:IAO_0000115 "a vaccine stabilizer that is specifically made by a sugar." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "sugar vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0000853 .

obo:VO_0003035
    obo:IAO_0000115 "a vaccine stabilizer that is generated based on amino acids. " ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "amino acid vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0000853 .

obo:VO_0003036
    obo:IAO_0000115 "a vaccine stabilizer that is specifically made by a sucrose. " ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "sucrose vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0003034 .

obo:VO_0003037
    obo:IAO_0000115 "a vaccine stabilizer that is specifically made by a lactose." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "lactose vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0003034 .

obo:VO_0003038
    obo:IAO_0000115 "a vaccine stabilizer that is a protein." ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "protein vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0000853 .

obo:VO_0003039
    obo:IAO_0000115 "a polysorbate 20 vaccine stabilizer that is Alkest TW20.  " ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "Alkest TW 20 vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0000929 .

obo:VO_0003040
    obo:IAO_0000115 "a polysorbate 20 vaccine stabilizer that is Tween 20. " ;
    obo:IAO_0000117 "YH, YL" ;
    a owl:Class ;
    rdfs:label "Tween 20 vaccine stabilizer" ;
    rdfs:subClassOf obo:VO_0000929 .

obo:VO_0003041
    obo:IAO_0000115 "an antibiotics vaccine residual that has the antibiotics of neomycin. " ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "neomycin residual" ;
    rdfs:subClassOf obo:VO_0000704 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000704
            [
                a owl:Restriction ;
                owl:onProperty obo:BFO_0000051 ;
                owl:someValuesFrom obo:CHEBI_7507
            ]
        )
    ] .

obo:VO_0003042
    obo:IAO_0000115 "the vaccine antiegn that induces protective immune response. " ;
    obo:IAO_0000117 "YL, YH" ;
    a owl:Class ;
    rdfs:label "protective vaccine antigen"@en ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000919
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000457
            ]
        )
    ] .

obo:VO_0003043
    obo:IAO_0000115 "A viral vaccine against infection of an Sindbis virus." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Sindbis virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11034
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11034
    ] .

obo:VO_0003044
    obo:IAO_0000115 "A viral vaccine against infection of a Lymphocytic choriomeningitis virus." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Lymphocytic choriomeningitis virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11623
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11623
    ] .

obo:VO_0003045
    a owl:Class ;
    rdfs:label "RB51 induced protection against B.suis" ;
    rdfs:subClassOf obo:VO_0003086, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000057 ;
        owl:someValuesFrom obo:NCBITaxon_29461
    ] .

obo:VO_0003046
    obo:IAO_0000115 "A protozoan vaccine against Schistosoma mansoni" ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Schistosoma mansoni vaccine"@en ;
    rdfs:subClassOf obo:VO_0003047, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9913
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5866
    ] .

obo:VO_0003047
    obo:IAO_0000115 "A protozoan vaccine against Schistosoma infection" ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Schistosoma vaccine"@en ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6181
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6181
    ] .

obo:VO_0003048
    obo:IAO_0000115 "when the vaccination of a significant portion of a population (or herd), in contagious diseases that are transmitted from individual to individual, chains of infection are likely to be disrupted, so the large numbers of a population are immue or less susceptible to the disease. " ;
    obo:IAO_0000117 "YL" ;
    obo:IAO_0000119 "http://en.wikipedia.org/wiki/Herd_immunity" ;
    a owl:Class ;
    rdfs:label "vaccine-induced herd immunity" ;
    rdfs:subClassOf obo:VO_0000288 .

obo:VO_0003049
    obo:IAO_0000115 "The conjugate protein is a part of a conjugate vaccine and acts as a carrier protein that is covalently attached to a vaccine antigen with poor antigenicity (e.g., a polysaccharide). A conjugate protein is able to induce T-cell-dependent immune responses and stimulate the production of immune memory." ;
    obo:IAO_0000117 "YL,YH" ;
    a owl:Class ;
    rdfs:label "vaccine conjugate protein" ;
    rdfs:subClassOf obo:VO_0000179 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000179
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0003050
            ]
        )
    ] .

obo:VO_0003050
    obo:IAO_0000115 "role inheres in a material eneitity that union itself chemically with a relative weak vaccine antigen to form a new whole that can create an effective miinuogen. The " ;
    dc:creator "YL" ;
    a owl:Class ;
    rdfs:label "vaccine conjugate role" ;
    rdfs:subClassOf obo:VO_0000617 .

obo:VO_0003051
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:comment "epicutaneous (application onto the skin), e" ;
    rdfs:label "percutaneous route" ;
    rdfs:subClassOf obo:VO_0000574 .

obo:VO_0003052
    obo:IAO_0000117 "Administration of a drug by the way of absorption through the skin, usually for systemic action. The route allows sustained therapeutic plasma drug levels and avoids first pass effect. Simplicity of administration tends to result in high patient compliance.", "YL" ;
    a owl:Class ;
    rdfs:label "percutaneous vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0003051
    ] .

obo:VO_0003053
    a owl:Class ;
    rdfs:label "intravesical route" ;
    rdfs:subClassOf obo:VO_0000574, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0001255
    ] .

obo:VO_0003054
    obo:IAO_0000115 "The injection of a given substance directly into the bladder via a urethral catheter instead of being injected under the skin." ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:label "intravesical vaccination" ;
    rdfs:subClassOf obo:VO_0000002, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000066 ;
        owl:someValuesFrom obo:VO_0003053
    ] .

obo:VO_0003055
    obo:IAO_0000115 "A viral vaccine against infection of a Lymphocytic choriomeningitis virus." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Infectious pancreatic necrosis virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11002
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11002
    ] .

obo:VO_0003056
    obo:IAO_0000115 "A viral vaccine against infection of a viral haemorrhagic septicaemia virus." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "viral haemorrhagic septicaemia virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11287
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11287
    ] .

obo:VO_0003057
    obo:IAO_0000115 "an vaccine-induced host response that shows augmented protection and cellular immunity after a host protein is used as adjuvant. " ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "augmented protection and cellular immunity using host protein as adjuvant" ;
    rdfs:subClassOf obo:VO_0000288 .

obo:VO_0003058
    obo:IAO_0000115 "A vaccine that protects against Mycobacterium marinum." ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Mycobacterium marinum vaccine"@en ;
    rdfs:subClassOf obo:VO_0000592 .

obo:VO_0003059
    obo:IAO_0000115 "A viral vaccine that protects against infection with Hepatitis D virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis D virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12475
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12475
    ] .

obo:VO_0003060
    obo:IAO_0000115 "viral vaccine that is used to protect against Monkeypox virus infection" ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Monkeypox virus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10244
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10244
    ] .

obo:VO_0003061
    obo:IAO_0000115 "viral vaccine that is used to protect against Bovine viral diarrhea virus 2 infection" ;
    obo:IAO_0000117 "YH, RS" ;
    a owl:Class ;
    rdfs:label "Bovine viral diarrhea virus 2 vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_54315
    ] .

obo:VO_0003062
    obo:IAO_0000115 "A viral vaccine that protects against infection with Murine Cytomegalovirus (or called murid herpesvirus 1)." ;
    obo:IAO_0000117 "YH, RS, NF" ;
    obo:IAO_0000118 "murine cytomegalovirus vaccine" ;
    a owl:Class ;
    rdfs:label "Murid herpesvirus 1  vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10366
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10366
    ] .

obo:VO_0003063
    a owl:Class ;
    rdfs:label "RB51 induced protection against B.abortus" ;
    rdfs:subClassOf obo:VO_0003086, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000057 ;
        owl:someValuesFrom obo:NCBITaxon_235
    ] .

obo:VO_0003064
    a owl:Class ;
    rdfs:label "RB51 induced protection against B.canis" ;
    rdfs:subClassOf obo:VO_0003086, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000057 ;
        owl:someValuesFrom obo:NCBITaxon_36855
    ] .

obo:VO_0003065
    a owl:Class ;
    rdfs:label "RB51 induced protection against B.Melitensis" ;
    rdfs:subClassOf obo:VO_0003086, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000057 ;
        owl:someValuesFrom obo:NCBITaxon_29459
    ] .

obo:VO_0003066
    obo:IAO_0000117 "Kallan Roan, Oliver He, OT" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601403", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm431374.htm"^^xsd:anyURI, "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM431447.pdf" ;
    obo:VO_0003099 "BEXSERO"^^xsd:anyURI ;
    obo:VO_0003158 "Meningococcal Group B Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Novartis Vaccines and Diagnostics, Inc"^^xsd:anyURI ;
    obo:VO_0003160 "Active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B in individuals 10 through 25 years of age."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM431447.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125546"^^xsd:anyURI ;
    obo:VO_0003198 1601403 ;
    a owl:Class ;
    rdfs:label "Bexsero"@en ;
    rdfs:seeAlso "CVX: 163", "VIOLIN Vaccine ID: 5576" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003347
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003360
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003362
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003364
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000696 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003067
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000119 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM524684.pdf" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Flublok Quadrivalent" ;
    rdfs:label "Flublok Quadrivalent"@en ;
    rdfs:seeAlso "CVX: 155", "VIOLIN Vaccine ID: 5556" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003069 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003068
    a owl:Class ;
    rdfs:label "RB51 induced host immune response" ;
    rdfs:subClassOf obo:VO_0000287, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000462 ;
        owl:someValuesFrom obo:VO_0000021
    ] .

obo:VO_0003069
    obo:IAO_0000119 "http://www.proteinsciences.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Protein Sciences Corporation"@en .

obo:VO_0003070
    obo:IAO_0000117 "OT, YH." ;
    obo:IAO_0000119 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM502899.pdf" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Flucelvax Quadrivalent" ;
    rdfs:label "Flucelvax Quadrivalent"@en ;
    rdfs:seeAlso "CVX: 171", "VIOLIN Vaccine ID: 5561" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000689 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003071
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm366061.htm"^^xsd:anyURI, "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM404086.pdf" ;
    obo:VO_0003099 "FluLaval"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza Virus Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "GlaxoSmithKline Biological (Parent Organization)"^^xsd:anyURI, "ID Biomedical Corporation of Quebec"^^xsd:anyURI ;
    obo:VO_0003160 "For active immunization of persons 6 months of age and older for the prevention of disease caused by influenza A subtype viruses and type B viruses contained in the vaccine."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM619548.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125163"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "FluLaval Quadrivalent"@en ;
    rdfs:seeAlso "CVX: 158", "VIOLIN Vaccine ID: 5562" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003072
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000119 "http://ca.gsk.com/media/590283/flulaval-tetra.pdf" ;
    a owl:Class ;
    rdfs:comment "Product Name: Quadrivalent Influenza Vaccine (Split Virion, Inactivated)"^^xsd:string, "Trade Name: FluLaval Tetra" ;
    rdfs:label "FluLaval Tetra"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 5563" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003073
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm356091.htm"^^xsd:anyURI ;
    obo:VO_0003099 "Fluzone Quadrivalent"^^xsd:anyURI ;
    obo:VO_0003158 "Influenza Virus Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Sanofi Pasteur Inc."^^xsd:anyURI ;
    obo:VO_0003160 "For active immunization of persons 6 months of age and older for the prevention of influenza disease caused by influenza A subtype viruses and type B viruses contained in the vaccine."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM356094.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 103914"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Fluzone Quadrivalent"@en ;
    rdfs:seeAlso "CVX: 158", "VIOLIN Vaccine ID: 5566" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003074
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000119 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM513242.pdf" ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza Virus Vaccine"^^xsd:string, "Trade Name: Fluzone Quadrivalent Southern Hemisphere" ;
    rdfs:label "Fluzone Quadrivalent - Southern Hemisphere Formulation"@en ;
    rdfs:seeAlso "CVX: 158", "VIOLIN Vaccine ID: 5568" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197912
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003075
    obo:IAO_0000117 "Kallan Roan, Oliver He, Omar Tibi, Khadeejah Khan" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597095", "https://www.cancer.org/latest-news/fda-approves-gardasil-9-hpv-vaccine.html", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm426445.htm"^^xsd:anyURI ;
    obo:VO_0003099 "Gardasil 9"^^xsd:anyURI ;
    obo:VO_0003158 "Human Papillomavirus 9-valent Vaccine, Recombinant"^^xsd:anyURI ;
    obo:VO_0003159 "Merck & CO., Inc."^^xsd:anyURI ;
    obo:VO_0003160 """Indicated in girls and women 9 through 45 years of age for the prevention of the following diseases:
- Cervical, vulvar, vaginal, and anal cancer caused by Human Papillomavirus (HPV) types 16, 18, 31, 33, 45, 52, and 58. (1.1)
Genital warts (condyloma acuminata) caused by HPV types 6 and 11. (1.1)

And the following precancerous or dysplastic lesions caused by HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58:
- Cervical intraepithelial neoplasia (CIN) grade 2/3 and cervical adenocarcinoma in situ (AIS). (1.1)
- Cervical intraepithelial neoplasia (CIN) grade 1. (1.1)
- Vulvar intraepithelial neoplasia (VIN) grade 2 and grade 3. (1.1)
- Vaginal intraepithelial neoplasia (VaIN) grade 2 and grade 3. (1.1)
- Anal intraepithelial neoplasia (AIN) grades 1, 2, and 3. (1.1)

GARDASIL 9 is indicated in boys and men 9 through 45 years of age for the prevention of the following diseases:
- Anal cancer caused by HPV types 16, 18, 31, 33, 45, 52, and 58. (1.2)
- Genital warts (condyloma acuminata) caused by HPV types 6 and 11. (1.2)

And the following precancerous or dysplastic lesions caused by HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58:
- Anal intraepithelial neoplasia (AIN) grades 1, 2, and 3. (1.2)"""^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM426457.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "125508"^^xsd:anyURI ;
    obo:VO_0003198 1597095 ;
    a owl:Class ;
    rdfs:label "Gardasil 9"@en ;
    rdfs:seeAlso "CVX: 165", "VIOLIN Vaccine ID: 5546" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003300
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003301
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003302
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003303
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003305
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003306
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003307
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003308
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003076
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Valneva SE"@en .

obo:VO_0003077
    a owl:Class ;
    rdfs:label "RB51 induced protection against B. ovis" ;
    rdfs:subClassOf obo:VO_0003086, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000057 ;
        owl:someValuesFrom obo:NCBITaxon_236
    ] .

obo:VO_0003078
    obo:IAO_0000115 "An Israeli research and development laboratory" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Israel_Institute_for_Biological_Research" ;
    oboInOwl:hasURI "https://iibr.gov.il/Pages/home.aspx" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Israel Institute for Biological Research" .

obo:VO_0003079
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "PaxVax, Inc."@en .

obo:VO_0003080
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000119 "http://www.pfizer.ca/sites/g/files/g10028126/f/201604/Nimenrix_PM_184020_23Mar2016_E.pdf" ;
    a owl:Class ;
    rdfs:label "Nimenrix"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 5578" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003081
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593136", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm421020.htm"^^xsd:anyURI ;
    obo:VO_0003099 "TRUMENBA"^^xsd:anyURI ;
    obo:VO_0003158 "Meningococcal Group B Vaccine"^^xsd:anyURI ;
    obo:VO_0003159 "Wyeth Pharmaceuticals, Inc."^^xsd:anyURI ;
    obo:VO_0003160 "Indicated for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B. Trumenba is approved for use in individuals 10 through 25 years of age."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM421139.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125549"^^xsd:anyURI ;
    obo:VO_0003198 1593136 ;
    a owl:Class ;
    rdfs:label "Trumenba"@en ;
    rdfs:seeAlso "CVX: 162", "VIOLIN Vaccine ID: 5577" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003366
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003368
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003082
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1812946", "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM506235.pdf" ;
    obo:VO_0003198 1812946 ;
    a owl:Class ;
    rdfs:label "Vaxchora"@en ;
    rdfs:seeAlso "CVX: 174", "VIOLIN Vaccine ID: 5569" ;
    rdfs:subClassOf obo:VO_0000763, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003955
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003079 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003083
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000118 "H5N1 vaccine GSK" ;
    obo:IAO_0000119 "https://www.fda.gov/downloads/BiologicsBloodVaccines/SafetyAvailability/VaccineSafety/UCM376464.pdf" ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted"^^xsd:string ;
    rdfs:label "Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted by GSK"@en ;
    rdfs:seeAlso "CVX: 160", "VIOLIN Vaccine ID: 5553" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_102793
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003084
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000118 "H1N1 vaccine GSK" ;
    obo:IAO_0000119 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM190377.pdf" ;
    a owl:Class ;
    rdfs:comment "Product Name: Influenza A (H1N1) 2009 Monovalent Vaccine" ;
    rdfs:label "Influenza A (H1N1) 2009 Monovalent Vaccine (GlaxoSmithKline)"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 5552" ;
    rdfs:subClassOf obo:VO_0003211, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003085
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000119 "https://www.vaccineshoppecanada.com/document.cfm?file=adacel-polio_e.pdf" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Adacel-Polio" ;
    rdfs:label "Adacel-Polio"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 5549" ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000128
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_17076
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000917
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003086
    a owl:Class ;
    rdfs:label "RB51 induced immune protection" ;
    rdfs:subClassOf obo:VO_0003068 .

obo:VO_0003087
    a owl:Class ;
    rdfs:label "RB51 induced immune response without protection" ;
    rdfs:subClassOf obo:VO_0003068 .

obo:VO_0003088
    obo:IAO_0000117 "OT, YH" ;
    obo:IAO_0000119 "https://ca.gsk.com/media/589683/boostrix-polio.pdf" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Boostrix-Polio" ;
    rdfs:label "Boostrix-Polio"@en ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 5550" ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000917
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003089
    dc:source "https://www.bloomberg.com/research/stocks/private/snapshot.asp?privcapId=7884644" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:comment "Out of buisness" ;
    rdfs:label "Lederle Laboratories Division"@en .

obo:VO_0003090
    obo:IAO_0000115 "This vaccine is given to provide protection against diphtheria, tetanus, and pertussis in children between 6 weeks and 7 years old." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.drugs.com/mmx/tri-immunol.html", "https://www.hendricks.org/HealthLibrary/default.aspx?sid=1&pTitle=%2CDrug&ContentTypeID=26&ContentID=215&alpha=T&AdditionalTitle=Tri-Immunol" ;
    a owl:Class ;
    rdfs:comment "discontinued now" ;
    rdfs:label "Tri-Immunol"@en ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003089 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003091
    obo:IAO_0000115 "Influenza virus vaccine is used to prevent infection caused by influenza virus types A and B." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.drugs.com/mtm/fluogen-injectable.html" ;
    a owl:Class ;
    rdfs:label "Fluogen"@en ;
    rdfs:subClassOf obo:VO_0002497, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003125 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003092
    obo:IAO_0000115 "monovalent vaccine agianst poliomyelitis for infants 6-12 weeks of age, all immunized children up to 18 years of age, and high risk adults." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.rxlist.com/orimune-drug.htm" ;
    obo:VO_0003158 "Oral Poliovirus Vaccine" ;
    a owl:Class ;
    rdfs:label "Orimune vaccine"@en ;
    rdfs:subClassOf obo:VO_0003167, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003089 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003093
    obo:IAO_0000115 "A malaria vaccine that consists of hepatitis B surface antigen virus-like particles, incorporating a portion of the Plasmodium falciparum-derived circumsporozoite protein and a liposome-based adjuvant." ;
    obo:IAO_0000117 "YH, Randi Vita" ;
    obo:IAO_0000119 "PMID:20078211", "https://en.wikipedia.org/wiki/RTS,S", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829262/" ;
    obo:VO_0003099 "Mosquirix" ;
    a owl:Class ;
    rdfs:comment "In July 2015, RTS,S/AS01 was approved by the European Medicines Agency for immunization of children aged 6 weeks to 17 months against malaria under Article 58,12." ;
    rdfs:label "P. falciparum RTS,S/AS01"@en ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000464
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0011218
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000366
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003094
    a owl:Class ;
    rdfs:label "Pnu-Imune vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ] .

obo:VO_0003095
    obo:IAO_0000115 "Revaxis is a Diphtheria, Tetanus and Poliomyelitis (inactivated) vaccine manufactured by Sanofi Pasteur. This vaccine helps boost protection against diphtheria, tetanus and poliomyelitis (polio)." ;
    obo:IAO_0000118 "3-in-1 diphtheria, polio and tetanus vaccine (Revaxis)" ;
    obo:IAO_0000119 "http://www.netdoctor.co.uk/medicines/infections/a8594/revaxis-diphtheria-polio-and-tetanus-vaccine/", "https://www.medicines.org.uk/emc/files/pil.5581.pdf", "https://www.medicines.org.uk/emc/product/5581/smpc", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166496/" ;
    obo:VO_0003147 """Dose: 0.5-mL suspension for injection in a pre-filled syringe
Active ingredients:	
Purified diphtheria toxoid	≥2 IU (5 Lf)
Purified tetanus toxoid	≥20 IU (10 Lf)
Inactivated poliovirus type 1	40 DU
Inactivated poliovirus type 2	8 DU
Inactivated poliovirus type 3	32 DU
Adsorbant:	
Aluminum hydroxide.	0.35 mg (as aluminum)""" ;
    obo:VO_0003151 "0.5-mL suspension for injection in a pre-filled syringe" ;
    a owl:Class ;
    rdfs:comment "Revaxis is used for preventing diphtheria, tetanus and polio in children from six years of age, adolescents and adults. Revaxis is used for a booster vaccination against these diseases. It is given to teenagers at 14 years of age as part of the British childhood immunisation schedule." ;
    rdfs:label "Revaxis"@en ;
    rdfs:subClassOf obo:VO_0000943, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003096
    obo:IAO_0000115 "a Diphthpheria-Tetanus Absorbed vaccine for children 7 years of age and adults." ;
    obo:IAO_0000119 "Kallan Roan, Oliver He", "http://drug-info.in/ditanrix-diphtheria-tetanus-vaccine-adsorbed-glaxosmithkline" ;
    obo:VO_0003158 "TD Absorbed and DT Absorbed Vaccine" ;
    a owl:Class ;
    rdfs:label "Ditanrix"@en ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001145
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003097
    obo:IAO_0000115 "A rotavirus vaccine against severe diarrheal disease." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://web.stanford.edu/~siegelr/ShadmanRotashieldPaper.pdf" ;
    obo:VO_0003147 "Amphotericin B, Monosodium Glutamate (MSG), Sucrose, Bovine (cow) serum, Potassium Phosphate, Potassium monophosphate." ;
    a owl:Class ;
    rdfs:comment "discontinued in 2008" ;
    rdfs:label "Rotashield vaccine"@en ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_64220
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003098
    obo:IAO_0000115 "A more attenuated measles vaccine that targets measles virus strain Moraten." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://apps.who.int/iris/bitstream/handle/10665/266590/PMC2554544.pdf?sequence=1&isAllowed=y", "https://jamanetwork.com/journals/jama/article-abstract/341314" ;
    a owl:Class ;
    rdfs:comment "Developed sometime in 1968 therefore assumed to be discontinued" ;
    rdfs:label "Moraten vaccine"@en ;
    rdfs:subClassOf obo:VO_0000654, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000194
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003099
    obo:IAO_0000115 "An annotation property that represents the trade name of a product." ;
    obo:IAO_0000117 "YH" ;
    a owl:AnnotationProperty ;
    rdfs:label "trade name", "trade name"@en .

obo:VO_0003100
    obo:IAO_0000115 "An inactIve vaccine used to prevent tetanus." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://www.catalog.md/drugs/tevax.html", "https://www.atoute.org/n/IMG/pdf/Constituants_des_vaccins_version-actualisee.pdf" ;
    a owl:Class ;
    rdfs:comment "Discontinued in 2003" ;
    rdfs:label "Tevax vaccine"@en ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000165
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003101
    obo:IAO_0000115 "An active immunization against cholera, indicated only for individuals traveling to or residing in countries where cholera is endemic or epidemic." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.rxlist.com/cholera-vaccine-drug.htm#indications" ;
    a owl:Class ;
    rdfs:label "Cholera Vaccine, USP"@en ;
    rdfs:subClassOf obo:VO_0000763, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:VO_0001187
                obo:VO_0003019
                obo:VO_0003022
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003102
    obo:IAO_0000115 "a hexavalent vaccine that has been withrawn on June 2012 by the European commission" ;
    obo:IAO_0000118 "Hexavac Vaccine" ;
    obo:IAO_0000119 "http://www.ema.europa.eu/docs/en_GB/document_library/Public_statement/2012/08/WC500130968.pdf" ;
    a owl:Class ;
    rdfs:label "Hexavax"@en ;
    rdfs:subClassOf obo:VO_0000738, obo:VO_0000746, obo:VO_0010718, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000636
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000703 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003103
    obo:IAO_0000115 "A vaccine used to help prevent rabies infection in people who either have been, or are at risk of being bitten, licked or scratched by an animal infected with rabies virus." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://www.who.int/immunization_standards/vaccine_quality/Rabipur_Product_Insert.pdf" ;
    obo:VO_0003147 "Amphotericin B, Neomycin, Sucrose, Chlortetracycline hydrochloride, Sodium chloride, Bovine (cow) serum, Trometamol, Polygeline, Virus: Rabies, Disodium edentate (EDTA), Monopotassium glutamate" ;
    obo:VO_0003158 "Rabies Virus Vaccine" ;
    a owl:Class ;
    rdfs:label "Rabipur vaccine"@en ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_64220
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000696 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003104
    obo:IAO_0000119 "https://www.ndrugs.com/?s=rabiesvax" ;
    a owl:Class ;
    rdfs:label "Rabiesvax vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0003105
    obo:IAO_0000115 "LYMErix [Lyme Disease Vaccine (Recombinant OspA)] is a noninfectious recombinant vaccine developed and manufactured by SmithKline Beecham Biologicals. The vaccine contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli. Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded to the N terminus." ;
    obo:IAO_0000118 "Discontinued in 2002", "Kallan Roan, Oliver He", "lipoprotein outer surface a vaccine" ;
    obo:IAO_0000119 "https://wayback.archive-it.org/7993/20170405164754/https://www.fda.gov/ohrms/dockets/ac/01/briefing/3680b2_03.pdf", "https://www.rxlist.com/lymerix-drug.htm" ;
    a owl:Class ;
    rdfs:label "Lymerix"@en ;
    rdfs:subClassOf obo:VO_0004028, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000145
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003106
    obo:IAO_0000118 "DTP vaccine", "DTwP vaccine"@en ;
    a owl:Class ;
    rdfs:label "diphtheria, tetanus and whole cell pertussis vaccine" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003107
    obo:IAO_0000115 "A human diploid cell vaccine against rabies, a viral infectious disease." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.researchgate.net/publication/27190851_Vaccination_against_rabies_and_protective_antibodies_-_Comparison_of_ELISA_and_fluorescent_antibody_virus_neutralization_FAVN_assays" ;
    a owl:Class ;
    rdfs:label "Rabivac"@en ;
    rdfs:subClassOf obo:VO_0000609, obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003108
    obo:IAO_0000115 "This absorbed recombinant hepatitis B vaccine is indicated for active immunization against hepatitis B virus infection caused by all known subtypes in subjects of any age considered at risk of exposure to the virus." ;
    obo:IAO_0000118 "Genhevac B Pasteur" ;
    obo:IAO_0000119 "https://www.mesvaccins.net/web/vaccines/48-genhevac-b-pasteur", "https://www.ncbi.nlm.nih.gov/pubmed/8106774" ;
    a owl:Class ;
    rdfs:comment "Discontinued in 2016", "Kallan Roan, Oliver He" ;
    rdfs:label "Genhevac B"@en ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000636
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000703 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003109
    obo:IAO_0000115 "HPV77/DE5 strain"^^xsd:anyURI ;
    obo:IAO_0000117 "Kallan Roan, Oliver He"^^xsd:anyURI ;
    obo:IAO_0000119 "http://americanhistory.si.edu/collections/search/object/nmah_733733"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:comment "Older version of Meruvax II" ;
    rdfs:label "Meruvax I"@en ;
    rdfs:subClassOf obo:VO_0010637, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003110
    obo:IAO_0000115 "A vaccine for indivuduals who at risk or recently exposed to rabies." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://onlinelibrary.wiley.com/doi/pdf/10.1002/0471704210.app4", "https://www.redalyc.org/html/579/57912962006/" ;
    a owl:Class ;
    rdfs:label "Rabie-Vax"@en ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003111
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "A vaccine for individuals to protect against mumps virus.", "https://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/cps-_monographs/CPS-_(General_Monographs-_M)/MUMPSVAX.html" ;
    a owl:Class ;
    rdfs:label "Mumpsvax II"@en ;
    rdfs:subClassOf obo:VO_0000656, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003112
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "A live RA 27/3 strain rubella vaccine"^^xsd:anyURI, "http://www.meppo.com/pdf/drugs/1538-RUDIVAX-1321626694.pdf", "https://www.ncbi.nlm.nih.gov/pubmed/6531969"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Rudivax"@en ;
    rdfs:subClassOf obo:VO_0010637, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000703 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003113
    obo:IAO_0000115 "An adsorbed diphtheria, tetanus, pertussis and inactivated poliomyelitis vaccine." ;
    obo:IAO_0000119 "https://www.mesvaccins.net/web/vaccines/63-tetracoq", "https://www.researchgate.net/publication/289445706_Efficacy_and_safety_of_Tetracoq_vaccine" ;
    a owl:Class ;
    rdfs:comment "European/French vaccine", "Often administered with a HIB vaccine." ;
    rdfs:label "Tetracoq"@en ;
    rdfs:subClassOf obo:VO_0000664, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1513
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1717
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003114
    obo:IAO_0000115 "A vaccine for Diphtheria, haemophilus influenzae, pertussis, and tetanus diseases." ;
    obo:IAO_0000119 "https://www.drugs.com/mtm/trihibit.html" ;
    a owl:Class ;
    rdfs:comment "Discontinued in 2011" ;
    rdfs:label "Trihibit"@en ;
    rdfs:subClassOf obo:VO_0003168, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003115
    obo:IAO_0000115 "A vaccine against flu (influenza) in adults, especially in those who run an increased risk of experiencing associated complications in case they fall ill with flu." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.medicines.org.uk/emc/files/pil.6163.pdf" ;
    a owl:Class ;
    rdfs:comment "Seasonal", "The vaccine targets three strains of influenza virus, and is free of chicken/egg protein." ;
    rdfs:label "Optaflu"@en ;
    rdfs:subClassOf obo:VO_0000642, obo:VO_0002496, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003164 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003116
    obo:IAO_0000115 "A vaccine used to prevent diphtheria and tetanus in individuals over 6 years of age." ;
    obo:IAO_0000119 "http://www.catalog.md/drugs/td-rix.html", "https://www.impfkritik.de/upload/pdf/fachinfo/Td-Rix-GSK-2006-07.pdf" ;
    a owl:Class ;
    rdfs:comment "European/German vaccine" ;
    rdfs:label "TD-Rix"@en ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003117
    obo:IAO_0000115 "A combined live virus vaccine used to prevent measles, mumps, and rubella." ;
    obo:IAO_0000119 "http://vacvine.com/Vaccines/Details/319" ;
    a owl:Class ;
    rdfs:comment "need better source" ;
    rdfs:label "Virivac"@en ;
    rdfs:subClassOf obo:VO_0000731, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0000069
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003118
    obo:IAO_0000115 "A vaccine used to protect against measles, mumps, and rubella for 12-15 month-old individuals." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/18400341" ;
    a owl:Class ;
    rdfs:label "M-M-R I"@en ;
    rdfs:subClassOf obo:VO_0000731, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003119
    obo:IAO_0000115 "Active immunization against Haemophilius influenzae type b in recommended routinely for children at 24 months of age and for children at 15 months of age enrolled in child care facilities.", "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "HIBIMUNE" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745871/", "https://www.ndrugs.com/?s=hib-imune" ;
    a owl:Class ;
    rdfs:comment "Discontinued in 1988" ;
    rdfs:label "Hib-Imune"@en ;
    rdfs:subClassOf obo:VO_0000627, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003089 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003120
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000118 "MVA expressing antigen 85A", "modified vaccinia virus Ankara expressing antigen 85A" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/15502839" ;
    a owl:Class ;
    rdfs:label "MVA85A"@en ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0010936
    ] .

obo:VO_0003121
    obo:IAO_0000115 "A Haemophilus influenzae type B conjugate vaccine manufactured by GSB." ;
    obo:IAO_0000119 "https://www.drugs.com/mtm/omnihib.html", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745871/" ;
    a owl:Class ;
    rdfs:comment "Discontinued Vaccine" ;
    rdfs:label "OmniHIB"@en ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003122
    obo:IAO_0000115 "A vaccine against diphtheria, tetanus, and pertussis." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "A vaccine indicated for active immunization against diphtheria, tetanus, and pertussis (whooping cough) in infants and children 6 weeks to 7 years of age (prior to seventh birthday)." ;
    obo:IAO_0000119 "https://www.rxlist.com/certiva-drug.htm" ;
    a owl:Class ;
    rdfs:label "Certiva"@en ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003123 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003123
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Abbot Laboratories"@en .

obo:VO_0003124
    a owl:Class ;
    rdfs:label "Fluogen - obsolete"@en ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0003125
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Parke, Davis, Company"@en .

obo:VO_0003126
    obo:IAO_0000115 "A TB vaccine that uses attenuated fowlpox strain FP9 to express mycobacterial mycolyl transferase Ag85A." ;
    obo:IAO_0000117 "YH" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=172", "https://www.ncbi.nlm.nih.gov/pubmed/15196215" ;
    a owl:Class ;
    rdfs:label "FP85A"@en ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0003127
    obo:IAO_0000115 "An object property that represents a relation between a vaccine with a prime-boost schedule and a vaccine used for priming." ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "has prime vaccine"@en ;
    rdfs:range obo:VO_0000001 .

obo:VO_0003128
    obo:IAO_0000115 "An object property that represents a relation between a vaccine with a prime-boost schedule and a vaccine used for boost." ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:VO_0000001 ;
    rdfs:label "has boost vaccine"@en ;
    rdfs:range obo:VO_0000001 .

obo:VO_0003129
    obo:IAO_0000115 "Pharmacotherapeutic group (ATC code): J 07 AN 01." ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000119 "http://www.immune.org.nz/vaccines/available-vaccines/bcg-vaccine-ssi", "https://www.hse.ie/eng/health/immunisation/hcpinfo/vaccineordering/bcgpil14.pdf" ;
    obo:VO_0003146 "Freeze-dried powder containing live attenuated bacteria of the type Mycobacterium bovis BCG, Danish strain 1331." ;
    obo:VO_0003147 "Sodium glutamate, magnesium sulphate heptahydrate, dipotassium phosphate, l-asparagine monohydrate, ferric ammonium citrate, glycerol 85%, citric acid, monohydrate and water for injections" ;
    a owl:Class ;
    rdfs:comment "Mycobacterium bovis BCG (Bacillus Calmette-Guérin), Danish strain 1331, live attenuated, 2–8 × 10^5 CFU per dose." ;
    rdfs:label "BCG Vaccine SSI"@en ;
    rdfs:subClassOf obo:VO_0000771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ] .

obo:VO_0003130
    obo:IAO_0000115 "A TB vaccine that uses BCG as vaccine vector." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "recombinant BCG vaccine"@en ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001014
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000138 ;
        owl:someValuesFrom obo:VO_0000771
    ] .

obo:VO_0003131
    obo:IAO_0000115 "A TB vaccine that recombinant BCG strain with the replacment of its urease C encoding gene with the listeriolysin encoding gene from Listeria monocytogenes." ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000118 "BCGΔureC::hly" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610719/" ;
    a owl:Class ;
    rdfs:label "VPM1002"@en ;
    rdfs:subClassOf obo:VO_0000603, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003132 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003132
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Max Planck Institute for Infection Biology"@en .

obo:VO_0003133
    obo:IAO_0000115 "The MRK adenovirus type 5 human immunodeficiency virus type 1 clade B gag/pol/nef vaccine is a replication-incompetent adenovirus type 5-vectored vaccine that elicits cell-mediated immunity against conserved human immunodeficiency virus proteins." ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000119 "PMID: 18433307", "https://www.ncbi.nlm.nih.gov/pubmed/18433307" ;
    obo:VO_0003146 "equal parts of 3 recombinant Ad5 vectors: MRKAd5gag, MRKAd5pol, and MRKAd5nef. E1 region of the Ad5 vector was deleted, which rendered the virus incapable of growing in human cells, and was replaced with a transgene construct that consisted of the human cytomegalovirus promoter; the HIV-1 clade B gag, pol, or nef open reading frame; and the bovine growth hormone poly A" ;
    a owl:Class ;
    rdfs:label "MRKAd5 HIV-1 gag/pol/nef"@en ;
    rdfs:subClassOf obo:VO_0000295 .

obo:VO_0003134
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:comment "A Yellow fever virus vaccine that uses the live attenated 17D strain."^^xsd:string ;
    rdfs:label "YF-17D vaccine"@en ;
    rdfs:subClassOf obo:VO_0000123, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003135
    obo:IAO_0000115 "A Yellow fever virus vaccine that uses the live attenated 17DD strain."^^xsd:string ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903908/" ;
    a owl:Class ;
    rdfs:comment "Two distinct strains of live attenuated yellow fever virus vaccine, 17D and 17DD, have been widely used. They have the same origin, from a yellow fever virus isolated from a patient with non fatal yellow fever named Asibi, from Ghana, in 1927. The 17D strain, used for vaccine production, corresponds to passage level 235–240 and the 17DD to a passage level 286–287. The comparison of the nucleotide sequences of all 17D vaccines showed an overall homology of 99.2%." ;
    rdfs:label "YF-17DD vaccine"@en ;
    rdfs:subClassOf obo:VO_0000123, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003136
    obo:IAO_0000115 "A YF-17DD vaccine t hat is manufactured by Bio-Manguinhos" ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    a owl:Class ;
    rdfs:label "YF 17DD-YFV"@en ;
    rdfs:subClassOf obo:VO_0003135, [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003137 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003137
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Bio-Manguinhos"@en .

obo:VO_0003138
    obo:IAO_0000115 "a licensed N. meningitidis vaccine that includes meningococcal polysaccharides from Groups A, C, Y and W-135 combined, and is manufactured by GSK."^^xsd:string ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000118 "ACWYVax" ;
    obo:IAO_0000119 "http://www.mhra.gov.uk/home/groups/comms-ic/documents/drugsafetymessage/con425089.pdf" ;
    obo:VO_0003146 "Meningococcal polysaccharides (groups A, C, W135 and Y polysaccharides)" ;
    obo:VO_0003147 "Lactose" ;
    a owl:Class ;
    rdfs:label "ACWY Vax"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001256
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003139
    obo:IAO_0000115 "It is live attenuated YFV vaccine strain 17D manufactured in China, France, Senegal, and the USA. In powder and solvent for suspension for injection in pre-filled syringe." ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000118 "17D-204" ;
    obo:IAO_0000119 "https://www.medicines.org.uk/emc/product/1683/smpc" ;
    obo:VO_0003146 "Yellow fever virus (produced in specified pathogen-free chick embryos), 17D strain (live, attenuated): not less than 1000 IU" ;
    obo:VO_0003147 "Lactose, sorbitol, L-histidine hydrochloride, L-alanine, sodium chloride, potassium chloride, sodium phosphate-dibasic dihydrate, potassium phosphate-monobasic, calcium chloride, magnesium sulfate and water for injections." ;
    a owl:Class ;
    rdfs:label "Stamaril"@en ;
    rdfs:subClassOf obo:VO_0003134, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000630
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003140
    obo:IAO_0000115 "A cancer vaccine against non-small cell lung cancer (NSCLC)" ;
    obo:IAO_0000118 "NSCLC vaccine" ;
    a owl:Class ;
    rdfs:label "non-small cell lung cancer vaccine"@en ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0003141
    obo:IAO_0000115 "A non-small cell lung cancer mRNA-derived vaccine that contains modified mRNAs encoding cancer-testis antigen NY-ESO-1, melanoma-associated antigens C1 (MAGE-C1/CT7) and C2 (MAGE-C2/CT10), survivin, and the oncofetal antigen 5T4 with potential antitumor and immunomodulatory activities." ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000119 "https://www.cancer.gov/publications/dictionaries/cancer-drug/def/non-small-cell-lung-cancer-mrna-derived-vaccine-cv9201" ;
    a owl:Class ;
    rdfs:comment "has active ingredients: 50% free mRNA (component 1) and 50% mRNA complexed with protamine (MEDA Pharma) at a weight ratio of 2:1 (component 2) -NSCLC-specific antigens NY-ESO1, MAGE-C1, MAGE-C2, Survivin, and 5T4" ;
    rdfs:label "CV9201"@en ;
    rdfs:subClassOf obo:VO_0003140, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0003142
    ] .

obo:VO_0003142
    obo:IAO_0000115 "A vaccine role that indicates a clinical trial status of a vaccine" ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "clinical trial vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0003143
    a owl:Class ;
    rdfs:label "licensed influenza vaccine"@en ;
    rdfs:subClassOf obo:VO_0000642 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000642
            [
                a owl:Restriction ;
                owl:onProperty obo:RO_0000087 ;
                owl:someValuesFrom obo:VO_0000630
            ]
        )
    ] .

obo:VO_0003144
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000119 "https://www.medicines.org.uk/emc/product/6355/smpc" ;
    obo:VO_0003146 "influenza vaccine (surface antigen, inactivated): (haemagglutinin and neuraminidase) of the following strains*: (A/Singapore/GP1908/2015, IVR-180) 15 micrograms HA, (A/Singapore/INFIMH-16-0019/2016, NIB-104) 15 micrograms HA,  (B/Maryland/15/2016, NYMC BX-69A) 15 micrograms HA" ;
    obo:VO_0003147 "potassium chloride, potassium dihydrogen phosphate, disodium phosphate dihydrate, sodium chloride, calcium chloride dihydrate, magnesium chloride hexahydrate and water for injections" ;
    a owl:Class ;
    rdfs:label "Imuvac"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003145 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003145
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Mylan Products Limited"@en .

obo:VO_0003146
    obo:IAO_0000115 "An annotation property that represents the active ingredient of a vaccine." ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:AnnotationProperty ;
    rdfs:label "has vaccine active ingredient", "has vaccine active ingredient"@en ;
    rdfs:subPropertyOf obo:VO_0003147 .

obo:VO_0003147
    obo:IAO_0000115 "An annotation property that represents the vaccine ingredient of a vaccine. Such an ingredient may not be active." ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:AnnotationProperty ;
    rdfs:label "has vaccine ingredient", "has vaccine ingredient"@en .

obo:VO_0003148
    obo:IAO_0000115 "LIPO-5 is a therapeutic HIV vaccine made up of lipopeptides, Study Names: VRI02/ANRS 149 LIGHT; NCT01492985" ;
    obo:IAO_0000117 "Oliver He, Randi Vita" ;
    obo:IAO_0000118 "ANRS HIV-LIPO-5, HIV-LIPO-5" ;
    obo:IAO_0000119 "https://aidsinfo.nih.gov/drugs/572/lipo-5/0/patient" ;
    obo:VO_0003146 "5 synthetic HIV-1 peptide fragments, which contain multiple CD8 and CD4 cell epitopes: Gag (amino acids 17 to 35), Gag (amino acids 253 to 284), Pol (amino acids 325 to 355), Nef (amino acids 66 to 97), and Nef (amino acids 116 to 145). The peptides are covalently attached to a palmitoyl-lysylamide moiety that facilitates entry into antigen-presenting DCs and enhances vaccine immunogenicity" ;
    a owl:Class ;
    rdfs:comment "LIPO-5 is in Phase II development as a therapeutic HIV vaccine. (LIPO-5 is also being studied as a preventive HIV vaccine.)" ;
    rdfs:label "LIPO-5"@en ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0003142
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003149 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003149
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "French National Agency for Research on AIDS and Viral Hepatitis (ANRS)"@en .

obo:VO_0003150
    obo:IAO_0000115 "A Hepatitis B virus vaccine that uses recombinant Hepatitis B surface antigen as the antigen" ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797752", "https://en.wikipedia.org/wiki/Hepatitis_B_vaccine" ;
    obo:VO_0003198 797752 ;
    obo:VO_0003560 "Hepatitis B Surface Antigen Vaccine" ;
    a owl:Class ;
    rdfs:comment "CUI: C0062527", "RXAUI: 2850925", "TUI: T116, T129, T121" ;
    rdfs:label "Hepatitis B surface antigen vaccine"@en ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000028
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003152
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000525 ;
        owl:someValuesFrom obo:VO_0011093
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000525 ;
        owl:someValuesFrom obo:VO_0011093
    ] .

obo:VO_0003151
    obo:IAO_0000115 "An annotation property that describes the dose information of a vaccine" ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:AnnotationProperty ;
    rdfs:label "vaccine dose annotation", "vaccine dose annotation"@en .

obo:VO_0003152
    obo:IAO_0000115 "A Hepatitis B surface antigen viral vaccine that utilizes a cytidine-phosphate-guanosine oligodeoxynucleotide (CpGODN) 1018, as an adjuvant." ;
    obo:IAO_0000117 "Oliver He, Randi Vita, Kallan Roan" ;
    obo:IAO_0000118 "HBsAg-1018" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1994348", "https://www.ncbi.nlm.nih.gov/pubmed/22342916" ;
    obo:VO_0003198 1994348 ;
    a owl:Class ;
    rdfs:label "HEPLISAV-B"@en ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003150
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0003154
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003153 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003153
    obo:IAO_0000115 "A company trhat is located at Berkeley, CA, USA. Its website is: http://www.dynavax.com." ;
    obo:IAO_0000117 "Oliver He, Randi Rita, Kallan Roan" ;
    obo:IAO_0000119 "http://www.dynavax.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Dynavax Technologies Corporation"@en .

obo:VO_0003154
    obo:IAO_0000115 "A CpG DNA vaccine adjuvant that is a short, synthetic, unmethylated CpG oligodeoxynucleotide (CpG ODN) with immunostimulatory activity." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000118 "ISS 1018 CpG ODN", "ISS 1018 CpG oligodeoxynucleotide", "ISS-1018" ;
    obo:IAO_0000119 "https://www.cancer.gov/publications/dictionaries/cancer-drug/def/iss-1018-cpg-oligodeoxynucleotide", "https://www.drugbank.ca/drugs/DB05463" ;
    dc:description "ISS 1018 is a short, synthetic, unmethylated CpG oligodeoxynucleotide (CpG ODN) with immunostimulatory activity. ISS 1018 signals through Toll-like receptor 9 (TLR9) to induce the production of immunoglobulin by B cells and interferon (IFN) -alpha, IFN-beta, interleukin-12 (IL-12), and tumor necrosis factor - alpha (TNF-alpha) by plasmacytoid dendritic cells (pDC). ISS 1018 CpG ODN promotes antigen presentation and co-stimulatory molecule expression. ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent Hepatitis B in adults. It is also being investigated in combination with rituximab for treatment of b-cell or non-hodgkin's lymphoma." ;
    a owl:Class ;
    rdfs:label "ISS 1018 CpG ODN vaccine adjuvant"@en ;
    rdfs:seeAlso "DrugBank Accession number: DB05463" ;
    rdfs:subClassOf obo:VO_0001237 .

obo:VO_0003155
    obo:IAO_0000117 "Oliver He, Kallan Roan, Randi Rita" ;
    obo:IAO_0000119 "A recombinant vesicular stomatitis virus Indiana serotype (rVSV) vector vaccine taht  expresses Zaire GP", "https://www.ncbi.nlm.nih.gov/pubmed/15937495" ;
    a owl:Class ;
    rdfs:label "rVSV-ZEBOV"@en ;
    rdfs:subClassOf obo:VO_0004660, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0010910
    ] .

obo:VO_0003156
    obo:IAO_0000115 "A human paillomavirus vaccine that has the vaccine antigen ingredient of monovalent non-infectious, L1 recombinant HPV-like particles (VLP)." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan, Randi Rita" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/12854090" ;
    a owl:Class ;
    rdfs:label "HPV-16 L1 VLP"@en ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0011108
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003157 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003157
    obo:IAO_0000115 "Novavax, Inc. is a clinical-stage biotechnology company committed to delivering novel products to prevent a broad range of infectious diseases." ;
    obo:IAO_0000119 "http://novavax.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Novavax, Inc."@en .

obo:VO_0003158
    obo:IAO_0000112 "The vaccine Prevnar (trade name) has a FDA-defined proper name: Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein). Reference:  https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm180017.htm" ;
    obo:IAO_0000115 "An annotation property that represents the proper name of a vaccine, which is defined in an official way such as one defined by FDA." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    a owl:AnnotationProperty ;
    rdfs:label "vaccine proper name", "vaccine proper name"@en .

obo:VO_0003159
    obo:IAO_0000112 "The vaccine Prevnar has the manufacturer: Wyeth Pharmaceuticals Inc. Reference: https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm180017.htm" ;
    obo:IAO_0000115 "An annotation property that represents the manufacturer of a product such as vaccine" ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    a owl:AnnotationProperty ;
    rdfs:label "manufacturer", "manufacturer"@en .

obo:VO_0003160
    obo:IAO_0000112 """The vaccine Prevnar has the indications:
- Immunization of infants 2, 4, 6 and 12-15 months of age to prevent invasive pneumococcal disease.
- Immunization of infants and toddlers against otitis media caused by vaccine serotypes.
Reference: https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm180017.htm""" ;
    obo:IAO_0000115 "An annotation property that represents the indications of a vaccine defined by the USA FDA." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    a owl:AnnotationProperty ;
    rdfs:label "FDA vaccine indications", "FDA vaccine indications"@en .

obo:VO_0003161
    obo:IAO_0000112 "Prevnar has the package insert PDF URL: https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM137038.pdf . Recorded on 11/26/2018." ;
    obo:IAO_0000115 "An annotation property that represents a URL of the package insert PDF document of a licensed vaccine" ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    a owl:AnnotationProperty ;
    rdfs:label "vaccine package insert PDF URL", "vaccine package insert PDF URL"@en .

obo:VO_0003162
    obo:IAO_0000115 "A number that is generated by FDA based on a request from an applicant of a product licensing." ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000118 "vaccine submission’s tracking number"@en ;
    obo:IAO_0000119 "https://www.fda.gov/downloads/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/ProceduresSOPPs/UCM461225.pdf" ;
    obo:VO_0003162 "BLA 101094" ;
    a owl:AnnotationProperty ;
    rdfs:label "vaccine STN" .

obo:VO_0003163
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    oboInOwl:hasURI "https://www.tevausa.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Teva Pharmaceuticals USA, Inc."@en .

obo:VO_0003164
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    oboInOwl:hasURI "https://www.seqirus.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Seqirus, Inc."@en .

obo:VO_0003165
    obo:IAO_0000115 "An inactivated Japanese encephalitis vaccine (JVax *) for use by certain travelers to and expatriates in Asia." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.cdc.gov/mmwr/preview/mmwrhtml/00018184.htm" ;
    a owl:Class ;
    rdfs:label "J-Vax"@en ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003166 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003166
    obo:IAO_0000115 "Located in Swiftwater, Pennsylvania, this company is now known as Sanofi Pasteur Limited." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Connaught Laboratories, Inc."@en .

obo:VO_0003167
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "A viral vaccine that protects against infection with Poliovirus administered orally.", "http://polioeradication.org/polio-today/polio-prevention/the-vaccines/opv/", "https://www.who.int/biologicals/areas/vaccines/polio/opv/en/" ;
    a owl:Class ;
    rdfs:label "Oral Poliovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000664, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003168
    obo:IAO_0000115 "A combination vaccine that protects against diphtheria, tetanus, pertussis, and Haemophilus influenzae type B." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTaP-Hib vaccine" ;
    a owl:Class ;
    rdfs:comment "Contains pertussis in acellular form." ;
    rdfs:label "Diphtheria-Tetanus-Acellular Pertussis-Haemophilus b vaccine"@en ;
    rdfs:subClassOf obo:VO_0000756, obo:VO_0000942 .

obo:VO_0003169
    obo:IAO_0000115 "A combination vaccine that protects against diphtheria, tetanus, pertussis, and Haemophilus influenzae type B." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTP-Hib vaccine" ;
    a owl:Class ;
    rdfs:comment "Contains killed whole cells of bacterium that causes pertussis." ;
    rdfs:label "Diphtheria-Tetanus-Whole Cell Pertussis-Haemophilus b vaccine"@en ;
    rdfs:subClassOf obo:VO_0000942 .

obo:VO_0003170
    obo:IAO_0000115 "A vaccine used to develop immunity to rabies." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a owl:Class ;
    rdfs:comment "Discontinued" ;
    rdfs:label "Imovax ID"@en ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003019
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003171
    obo:IAO_0000115 "A live virus vaccine for immunization against measles and rubella." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.rxlist.com/m-r-vax-ii-drug.htm" ;
    a owl:Class ;
    rdfs:label "MR-VAX II"@en ;
    rdfs:subClassOf obo:VO_0000945, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0000007
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0000073
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003172
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTP-HepB vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Hepatitis B vaccine"@en ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0003173
    obo:IAO_0000115 "Active immunzation against diphtheria, tetanus, pertussis and hepatitis B (HBV) in infants from 6 weeks onwards" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Tritanrix HB" ;
    obo:IAO_0000119 "https://www.ema.europa.eu/en/tritanrix-hb-h-w-3838" ;
    a owl:Class ;
    rdfs:label "Tritanrix"@en ;
    rdfs:subClassOf obo:VO_0003172, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003174
    obo:IAO_0000115 "A vaccine used to prevent diphtheria, tetanus, pertussis, and Haemophilus type B infections." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.hendricks.org/HealthLibrary/default.aspx?sid=1&pTitle=%2CDrug&ContentTypeID=26&ContentID=1027&alpha=A&AdditionalTitle=ActHIB%C2%AE+With+DTP" ;
    a owl:Class ;
    rdfs:label "DTP-ActHIB"@en ;
    rdfs:subClassOf obo:VO_0000942, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0000004
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000700 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003175
    obo:IAO_0000115 "An oral vaccine against adenovirus serotype 4." ;
    obo:IAO_0000119 "https://health.mil/Military-Health-Topics/Health-Readiness/Immunization-Healthcare/Vaccine-Preventable-Diseases/Adenovirus" ;
    a owl:Class ;
    rdfs:comment "Kallan Roan, Oliver He", "The vaccine is in a form of  white enteric-coated tablets. It is typically administered with Adenovirus type 7 vaccine." ;
    rdfs:label "Adenovirus Type 4"@en ;
    rdfs:subClassOf obo:VO_0000037, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004869
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003164 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003176
    obo:IAO_0000115 "An oral vaccine against adenovirus serotype 7." ;
    obo:IAO_0000119 "Kallan Roan, Oliver He", "The vaccine is in a form of peach-colored enteric-coated tablets. It is typically administered with Adenovirus type 4 vaccine.", "https://health.mil/Military-Health-Topics/Health-Readiness/Immunization-Healthcare/Vaccine-Preventable-Diseases/Adenovirus" ;
    a owl:Class ;
    rdfs:label "Adenovirus Type 7"@en ;
    rdfs:subClassOf obo:VO_0000037, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004871
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003164 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003177
    obo:IAO_0000115 "A vaccine that protects against, Diphtheria, Tetanus, Pertussis (whooping cough), Polio, and Haemophilus influenzae type b." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTAP/IPV/ACT-HIB" ;
    obo:IAO_0000119 "https://insights.ovid.com/pubmed?pmid=9849987" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-ACT-Hib vaccine"@en ;
    rdfs:subClassOf obo:VO_0000744, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002180 ;
        owl:someValuesFrom obo:VO_0000004
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003166 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003178
    obo:IAO_0000115 "Active immunization against tetanus, diphtheria, pertussis, and poliomyelitis for individuals between 3 months and 6 years of age." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.impfkritik.de/upload/pdf/fachinfo/quatro-virelon-chiron-behring.pdf" ;
    a owl:Class ;
    rdfs:label "Quatro Virelon"@en ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003179 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003179
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Chiron Behring Vaccines Private Ltd"@en .

obo:VO_0003180
    obo:IAO_0000115 "A vaccine that protects adolescents and adults from tetanus, diphtheria, and pertussis." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.cdc.gov/vaccines/hcp/vis/vis-statements/tdap.html" ;
    a owl:Class ;
    rdfs:comment "Tdap is different than the DTaP vaccine, which is given to infants and children in five doses, starting at 2 months of age." ;
    rdfs:label "TDAP"@en ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003181
    obo:IAO_0000115 "A measles virus vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Measles virus vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000654, obo:VO_0003444 .

obo:VO_0003182
    obo:IAO_0000115 "A Mumps-Rubella vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Mumps-Rubella Vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0003418, obo:VO_0003444 .

obo:VO_0003183
    obo:IAO_0000115 "A Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine manufactured outside of the U.S" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000743, obo:VO_0003444 .

obo:VO_0003184
    obo:IAO_0000115 "A Diphtheria-Tetanus-Pertussis-Poliovirus vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000742, obo:VO_0003444 .

obo:VO_0003185
    obo:IAO_0000115 "A Haemophilis influenzae Type b capsular polysaccharide vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.drugs.com/mmx/haemophilus-influenzae-type-b-polysaccharide-vaccine.html" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "HIB Polysaccharide foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000627, obo:VO_0003444 .

obo:VO_0003186
    obo:IAO_0000115 "A Hepatitis B vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.ema.europa.eu/documents/product-information/hbvaxpro-epar-product-information_en.pdf" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Hepatitis B vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000644, obo:VO_0003444 .

obo:VO_0003187
    obo:IAO_0000115 "A Diphtheria-Tetanus-Poliovirus vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166496/" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Diphtheria-Tetanus-Poliovirus vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000943, obo:VO_0003444 .

obo:VO_0003188
    obo:IAO_0000115 "A Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b-Hepatitis B vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.ema.europa.eu/medicines/human/EPAR/hexyon" ;
    obo:OBI_9991118 "DTaP/IPV/HepB/Hib vaccine foreign to USA" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b-Hepatitis B vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000946, obo:VO_0003444 .

obo:VO_0003189
    obo:IAO_0000115 "A seasonal Influenza virus vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://www.euro.who.int/en/health-topics/communicable-diseases/influenza/vaccination/types-of-seasonal-influenza-vaccine" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Seasonal Influenza virus vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000642, obo:VO_0003444 .

obo:VO_0003190
    obo:IAO_0000115 "A Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine manufactured outside of the U.S" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DTaP/IPV/Hib vaccine foreign to USA" ;
    obo:IAO_0000119 "https://ca.gsk.com/media/590970/infanrix-ipv-hib.pdf" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000744, obo:VO_0003444 .

obo:VO_0003191
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://vk.ovg.ox.ac.uk/ppv" ;
    a owl:Class ;
    rdfs:comment "A pneumococcal vaccine manufactured outside of the U.S.", "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Pneumococcal vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000424, obo:VO_0003444 .

obo:VO_0003192
    obo:IAO_0000115 "An active immunizing combination agent that is used to prevent infection caused by certain groups of meningococcal bacteria and Haemophilus influenza type b (Hib) bacteria." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.mayoclinic.org/drugs-supplements/meningococcal-vaccine-and-haemophilus-b-vaccine-intramuscular-route/description/drg-20075601" ;
    a owl:Class ;
    rdfs:label "Meningococcal Conjugate and Haemophilis B Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003441, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:VO_0000741
    ] .

obo:VO_0003193
    obo:IAO_0000115 "A Meningicoccal Conjugate and Haemophilis B Vaccine manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Meningococcal Conjugate and Haemophilis B Vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0003192, obo:VO_0003444 .

obo:VO_0003194
    obo:IAO_0000115 "A tick-borne encephalitis virus vaccine used to prevent subtype Far Eastern tick-borne encephalitis virus (formerly known as Russian Spring Summer encephalitis virus)." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.who.int/immunization/sage/1_TBE_PP_Draft_13_Mar_2011_SAGE_apr_2011.pdf?ua=1" ;
    a owl:Class ;
    rdfs:label "Spring Summer Encephalitis Vaccine"@en ;
    rdfs:subClassOf obo:VO_0012190, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003195
    obo:IAO_0000115 "A polysaccharide vaccine to prevent typhoid caused Salmonella typhi. Acetone is used to inactivate culture, and dried." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.cdc.gov/mmwr/pdf/rr/rr4314.pdf", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366340" ;
    a owl:Class ;
    rdfs:label "Acetone-Dried Typhoid Vi Polysaccharide vaccine"@en ;
    rdfs:subClassOf obo:VO_0001255, obo:VO_0003443, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003022
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003196
    obo:IAO_0000118 "acellular pertussis vaccine, inactivated" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798302" ;
    obo:VO_0003198 798302 ;
    a owl:Class ;
    rdfs:label "inactivated acellular pertussis vaccine"@en ;
    rdfs:subClassOf obo:VO_0000765 .

obo:VO_0003197
    obo:IAO_0000115 "A vaccine to protect individuals against infections caused by hepatitis A virus and typhoid fever bacteria." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Hepatitis A and Vi Polysaccharide typhoid vaccine foreign to USA" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/9772328" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "Hepatitis A virus-Typhoid vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0003229, obo:VO_0003444, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003198
    a owl:AnnotationProperty ;
    rdfs:label "RxNORM ID", "RxNORM ID"@en .

obo:VO_0003199
    obo:IAO_0000118 "B. pertussis pertactin vaccine"@en, "Bordetella pertussis pertactin vaccine" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300380" ;
    obo:VO_0003198 1300380 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis pertactin vaccine, inactivated" ;
    rdfs:subClassOf obo:VO_0003196, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000029
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000064
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003200
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300186" ;
    obo:VO_0003198 1300186 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis toxoid vaccine, inactivated"@en ;
    rdfs:subClassOf obo:VO_0003196, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000029
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000064
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003201
    a owl:Class ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated"@en ;
    rdfs:subClassOf obo:VO_0003196, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000029
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000064
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003202
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300182" ;
    obo:VO_0003198 1300182 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis fimbriae 2/3 vaccine, inactivated"@en ;
    rdfs:subClassOf obo:VO_0003196, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000029
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003203
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300380" ;
    obo:VO_0003198 1300380 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis pertactin vaccine, inactivated 0.016 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003199 .

obo:VO_0003204
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300185" ;
    obo:VO_0003198 1300185 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003199 .

obo:VO_0003205
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657600" ;
    obo:VO_0003198 1300365 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis pertactin vaccine, inactivated 0.005 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003199 .

obo:VO_0003206
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300366" ;
    obo:VO_0003198 1300366 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis toxoid vaccine, inactivated 0.016 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003200 .

obo:VO_0003207
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300381" ;
    obo:VO_0003198 1300381 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis toxoid vaccine, inactivated 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003200 .

obo:VO_0003208
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300187" ;
    obo:VO_0003198 1300187 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis toxoid vaccine, inactivated 0.005 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003200 .

obo:VO_0003209
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300307" ;
    obo:VO_0003198 1300307 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis toxoid vaccine, inactivated 0.02 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003200 .

obo:VO_0003210
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1988802" ;
    obo:VO_0003198 1988802 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003200 .

obo:VO_0003211
    obo:IAO_0000115 "A monovalent vaccine used to protect against H1N1 influenza virus." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm181950.htm" ;
    a owl:Class ;
    rdfs:label "H1N1 Influenza Monovalent Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0003212
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854930" ;
    obo:VO_0003198 854930 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 1 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003213
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "DP+IPV vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria Toxoid-Pertussis-Poliovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000735, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:NCBITaxon_12080
                obo:NCBITaxon_12083
                obo:NCBITaxon_12086
            )
        ]
    ] .

obo:VO_0003214
    obo:IAO_0000118 "DT+IPV+HIB+HEPB vaccine" ;
    a owl:Class ;
    rdfs:label "Diphtheria-Tetanus-Poliovirus-Haemophilus B-Hepatitis B vaccine"@en ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_10407
                obo:VO_0000741
                [
                    a owl:Class ;
                    owl:unionOf (obo:NCBITaxon_12080
                        obo:NCBITaxon_12083
                        obo:NCBITaxon_12086
                    )
                ]
            )
        ]
    ] .

obo:VO_0003215
    a owl:Class ;
    rdfs:label "Seasonal Influenza A27:H29 vaccine"@en ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0003216
    obo:IAO_0000115 """For the prevention of influenza caused by Influenza Virus, Types A and B. For the Southern
Hemisphere 2017 season, the vaccine is indicated for use only in persons aged 5 years and
over.""" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.medsafe.govt.nz/profs/Datasheet/f/Fluvaxinj.pdf" ;
    a owl:Class ;
    rdfs:label "Fluvax"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000689 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003217
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854934" ;
    obo:VO_0003198 854934 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 11A vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003218
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854936" ;
    obo:VO_0003198 854936 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 12F vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003219
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854938" ;
    obo:VO_0003198 854938 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 14 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003220
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854940" ;
    obo:VO_0003198 854940 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 15B vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003221
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854942" ;
    obo:VO_0003198 854942 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 17F vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003222
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854944" ;
    obo:VO_0003198 854944 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 18C vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003223
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854944" ;
    obo:VO_0003198 854944 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 19A vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003224
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854948" ;
    obo:VO_0003198 854948 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 19F vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003225
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854950" ;
    obo:VO_0003198 854950 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 2 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003226
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854952" ;
    obo:VO_0003198 854952 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 20 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003227
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854954" ;
    obo:VO_0003198 854954 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 22F vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003228
    obo:IAO_0000118 "1 ML Recombivax 0.04 MG/ML Injection", "RECOMBIVAX HB dialysis formulation vaccine 1 ML Injection", "Recombivax HB 40 MCG per 1 ML Injection", "Recombivax HB, Hepatitis B vaccine (recombinant) Dialysis Formulation 40 MCG per 1 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830263" ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.04 MG/ML Injection [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0010737 .

obo:VO_0003229
    a owl:Class ;
    rdfs:label "Hepatitis A virus-Typhoid vaccine"@en ;
    rdfs:subClassOf obo:VO_0000646, obo:VO_0000671 .

obo:VO_0003230
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830260" ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003150 .

obo:VO_0003231
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1994352" ;
    obo:VO_0003198 1994352 ;
    a owl:Class ;
    rdfs:comment "CUI: C4534702", "RXAUI: 9712934, 9712933, 9712931, 9712937", "TUI: T200" ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.04 MG/ML Injection [Heplisav-B]"@en ;
    rdfs:subClassOf obo:VO_0003270, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003968
    ] .

obo:VO_0003232
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854962" ;
    obo:VO_0003198 854962 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 4 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003233
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.04 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003421 .

obo:VO_0003234
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.04 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003421 .

obo:VO_0003235
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657331" ;
    obo:VO_0003198 1657331 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0000200 .

obo:VO_0003236
    obo:IAO_0000115 "A vaccine which helps prevent hepatitis A and typhoid fever. This vaccine should only be given to adults and teenagers aged 15 years and above." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.hpra.ie/img/uploaded/vaccines/PIL_PA1077099001.pdf" ;
    a owl:Class ;
    rdfs:label "Hepatyrix"@en ;
    rdfs:subClassOf obo:VO_0003229, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003237
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830212" ;
    obo:VO_0003198 830212 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.01 MG/ML [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0010737 .

obo:VO_0003238
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658155" ;
    obo:VO_0003198 1658155 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Injection [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0003237 .

obo:VO_0003239
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830245" ;
    obo:VO_0003198 830245 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Prefilled Syringe [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0003237 .

obo:VO_0003240
    a owl:Class ;
    rdfs:label "BCG Vaccine (by Organon Teknika)" ;
    rdfs:subClassOf obo:VO_0000771, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003052
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000697 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003241
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658150" ;
    obo:VO_0003198 1658150 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Injection [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0003237 .

obo:VO_0003242
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657683" ;
    obo:VO_0003198 1657683 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Injection [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0010737 .

obo:VO_0003243
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830244" ;
    obo:VO_0003198 830244 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Prefilled Syringe [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0010737 .

obo:VO_0003244
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830253" ;
    obo:VO_0003198 830253 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Prefilled Syringe [Recombivax]"@en ;
    rdfs:subClassOf obo:VO_0003243 .

obo:VO_0003245
    obo:IAO_0000232 """This may just be a synonym of Recombivax HB: 
https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf
because all the vaccine is injectable

RECOMBIVAX HB® Hepatitis B Vaccine (Recombinant)
Suspension for intramuscular injection
Initial U.S. Approval: 1986""" ;
    a owl:Class ;
    rdfs:label "Recombivax Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0010737 .

obo:VO_0003246
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854970" ;
    obo:VO_0003198 854970 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 8 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003247
    obo:IAO_0000115 "The site that is the part of the host body and the entrance point where a vaccine is administered. " ;
    obo:IAO_0000117 "YL" ;
    a owl:Class ;
    rdfs:comment "it is not the natural anatomical part where the body has access toward outside, such as mouth or nose. But rather the holes on the skin made by needdles used for vaccination." ;
    rdfs:label "vaccination site" ;
    rdfs:subClassOf obo:BFO_0000029, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000574
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0001025 ;
        owl:someValuesFrom obo:UBERON_0001062
    ] .

obo:VO_0003248
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854958" ;
    obo:VO_0003198 854958 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 3 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003249
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854960" ;
    obo:VO_0003198 854960 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 33F vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003250
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854966" ;
    obo:VO_0003198 854966 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 6B vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003251
    obo:IAO_0000115 "A trivalent inactive influenza virus vaccine." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Flu-imune" ;
    obo:IAO_0000119 "https://cvi.asm.org/content/cdli/1/1/16.full.pdf" ;
    a owl:Class ;
    rdfs:comment "Vaccine sold for 1993-1994 influenza season." ;
    rdfs:label "Flu-Imune"@en ;
    rdfs:subClassOf obo:VO_0002495, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003089 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003252
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854956" ;
    obo:VO_0003198 854956 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 23F vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003253
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854968" ;
    obo:VO_0003198 854968 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 7F vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003254
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854972" ;
    obo:VO_0003198 854972 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 9N vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003255
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854972" ;
    obo:VO_0003198 854972 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 5 vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003256
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797753" ;
    obo:VO_0003198 797753 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.02 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003150 .

obo:VO_0003257
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830236" ;
    obo:VO_0003198 830236 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.005 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003150 .

obo:VO_0003258
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798427" ;
    obo:VO_0003198 798427 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Prefilled Syringe [Engerix-B]"@en ;
    rdfs:subClassOf obo:VO_0015019 .

obo:VO_0003259
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658156" ;
    obo:VO_0003198 1658156 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003421 .

obo:VO_0003260
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658708" ;
    obo:VO_0003198 1658708 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0000200 .

obo:VO_0003261
    obo:IAO_0000117 "A quadrivalent influenza vaccine against two influenza A strains and two influenza B strains.", "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/24022123" ;
    a owl:Class ;
    rdfs:label "QIV Dresden"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003262
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658142" ;
    obo:VO_0003198 1658142 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003421 .

obo:VO_0003263
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798422" ;
    obo:VO_0003198 798422 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.02 MG/ML [Engerix-B]"@en ;
    rdfs:subClassOf obo:VO_0010711 .

obo:VO_0003264
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798428" ;
    obo:VO_0003198 798428 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Prefilled Syringe [Engerix-B]"@en ;
    rdfs:subClassOf obo:VO_0003258 .

obo:VO_0003265
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658157" ;
    obo:VO_0003198 1658157 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Injection [Engerix-B]"@en ;
    rdfs:subClassOf obo:VO_0015020 .

obo:VO_0003266
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658144" ;
    obo:VO_0003198 1658144 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Injection [Engerix-B]"@en ;
    rdfs:subClassOf obo:VO_0015020 .

obo:VO_0003267
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798430" ;
    obo:VO_0003198 798430 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Prefilled Syringe [Engerix-B]"@en ;
    rdfs:subClassOf obo:VO_0003258 .

obo:VO_0003268
    obo:IAO_0000115 "A combination vaccine against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b (Hib)." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.mesvaccins.net/web/vaccines/15-infanrixquinta" ;
    a owl:Class ;
    rdfs:label "Infanrix Quinta"@en ;
    rdfs:subClassOf obo:VO_0000744, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003269
    obo:IAO_0000117 "Oliver He, Khadeejah Khan" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854937" ;
    obo:VO_0003198 854937 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 12F vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003218 .

obo:VO_0003270
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1994350" ;
    obo:VO_0003198 1994350 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Injection [Heplisav-B]"@en ;
    rdfs:subClassOf obo:VO_0003965 .

obo:VO_0003271
    obo:IAO_0000115 "A combination vaccine against diphtheria, tetanus, pertussis, hepatitis B, and poliovirus." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://www.gsk.com.au/resources.ashx/vaccineproductschilddataproinfo/28/FileName/700FA5039310414550A80719A7B644CD/PI_Infanrix_Penta.pdf" ;
    a owl:Class ;
    rdfs:label "Infanrix Penta"@en ;
    rdfs:subClassOf obo:VO_0000743, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003272
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292432" ;
    obo:VO_0003198 1292432 ;
    a owl:Class ;
    rdfs:label "0.65 ML Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 29800 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003279 .

obo:VO_0003273
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292422" ;
    obo:VO_0003198 1292422 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain"@en ;
    rdfs:subClassOf obo:VO_0000419 .

obo:VO_0003274
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658006" ;
    obo:VO_0003198 1658006 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain Injection"@en ;
    rdfs:subClassOf obo:VO_0003273 .

obo:VO_0003275
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292423" ;
    obo:VO_0003198 1292423 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 2700 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003273 .

obo:VO_0003276
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292457" ;
    obo:VO_0003198 1292457 ;
    a owl:Class ;
    rdfs:label "0.5 ML Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 2700 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003275 .

obo:VO_0003277
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292424" ;
    obo:VO_0003198 1292424 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000419 .

obo:VO_0003278
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292436" ;
    obo:VO_0003198 1292436 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 20000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003273, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000091
    ] .

obo:VO_0003279
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292430" ;
    obo:VO_0003198 1292430 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 29800 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003273 .

obo:VO_0003280
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292432" ;
    obo:VO_0003198 1292432 ;
    a owl:Class ;
    rdfs:label "0.65 ML Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 29800 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003279 .

obo:VO_0003281
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658013" ;
    obo:VO_0003198 1658013 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain Injection [Zostavax]"@en ;
    rdfs:subClassOf obo:VO_0000124 .

obo:VO_0003282
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292433" ;
    obo:VO_0003198 1292433 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 29800 UNT/ML [Zostavax]"@en ;
    rdfs:subClassOf obo:VO_0003281 .

obo:VO_0003283
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292435" ;
    obo:VO_0003198 1292435 ;
    a owl:Class ;
    rdfs:label "0.65 ML Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 29800 UNT/ML Injection [Zostavax]"@en ;
    rdfs:subClassOf obo:VO_0003282 .

obo:VO_0003284
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide vaccine"@en ;
    rdfs:subClassOf obo:VO_0000675 .

obo:VO_0003285
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000675 .

obo:VO_0003286
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901622" ;
    obo:VO_0003198 901622 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 14 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003335 .

obo:VO_0003287
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901627" ;
    obo:VO_0003198 901627 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 23F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003340 .

obo:VO_0003288
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901630" ;
    obo:VO_0003198 901630 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003342 .

obo:VO_0003289
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901621" ;
    obo:VO_0003198 901621 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003334 .

obo:VO_0003290
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901635" ;
    obo:VO_0003198 901635 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 6B capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0088 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003345 .

obo:VO_0003291
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901638" ;
    obo:VO_0003198 901638 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 9V capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003346 .

obo:VO_0003292
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901626" ;
    obo:VO_0003198 901626 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 19F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003339 .

obo:VO_0003293
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901629" ;
    obo:VO_0003198 901629 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 3 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003341 .

obo:VO_0003294
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901632" ;
    obo:VO_0003198 901632 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 5 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003343 .

obo:VO_0003295
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901634" ;
    obo:VO_0003198 901634 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 6A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003344 .

obo:VO_0003296
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901625" ;
    obo:VO_0003198 901625 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 19A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003338 .

obo:VO_0003297
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901623" ;
    obo:VO_0003198 901623 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 18C capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003337 .

obo:VO_0003298
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901637" ;
    obo:VO_0003198 901637 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 7F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003333 .

obo:VO_0003299
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000667 .

obo:VO_0003300
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798268" ;
    obo:VO_0003198 798268 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 6 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000049
    ] .

obo:VO_0003301
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798262" ;
    obo:VO_0003198 798262 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 11 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003307
    ] .

obo:VO_0003302
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798266" ;
    obo:VO_0003198 798266 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 18 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000049
    ] .

obo:VO_0003303
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798264" ;
    obo:VO_0003198 798264 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 16 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000049
    ] .

obo:VO_0003304
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1596930" ;
    obo:VO_0003198 1596930 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 31 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299 .

obo:VO_0003305
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1596931" ;
    obo:VO_0003198 1596931 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 33 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299 .

obo:VO_0003306
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1596932" ;
    obo:VO_0003198 1596932 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 45 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299 .

obo:VO_0003307
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1596933" ;
    obo:VO_0003198 1596933 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 52 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299 .

obo:VO_0003308
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1596934" ;
    obo:VO_0003198 1596934 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 58 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003299 .

obo:VO_0003309
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854957" ;
    obo:VO_0003198 854957 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 23F vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003252 .

obo:VO_0003310
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854939" ;
    obo:VO_0003198 854939 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 14 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003219 .

obo:VO_0003311
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854969" ;
    obo:VO_0003198 854969 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 7F vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003253 .

obo:VO_0003312
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854965" ;
    obo:VO_0003198 854965 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 5 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003255 .

obo:VO_0003313
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854935" ;
    obo:VO_0003198 854935 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 11A vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003217 .

obo:VO_0003314
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854933" ;
    obo:VO_0003198 854933 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 10A vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003959 .

obo:VO_0003315
    obo:IAO_0000115 "A combination vaccine against diphtheria, tetanus, acellular pertussis, and inactivated poliomyelitis for individuals ages from 16 months to 13 years of age." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.mesvaccins.net/web/vaccines/51-infanrixtetra" ;
    a owl:Class ;
    rdfs:label "Infanrix Tetra"@en ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003316
    obo:IAO_0000115 "A vaccine that can be given to children after the age of 2 months up to 2 years to prevent infectious diseases caused by Haemophilus influenzae type b (Hib) and Neisseria meningitidis group C (MenC) bacteria." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.medicines.org.uk/emc/files/pil.167.pdf" ;
    a owl:Class ;
    rdfs:label "Menitorix"@en ;
    rdfs:subClassOf obo:VO_0003192, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003317
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:VO_0003099 "SHINGRIX" ;
    obo:VO_0003158 "Zoster Vaccine Recombinant, Adjuvanted" ;
    obo:VO_0003160 "Indicated for prevention of herpes zoster (shingles) in adults aged 50 years and older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM581605.pdf" ;
    obo:VO_0003162 125614 ;
    a owl:Class ;
    rdfs:label "Shingrix"@en ;
    rdfs:subClassOf obo:VO_0000669, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003802
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003318
    obo:IAO_0000115 "A vaccine against tetanus, diphtheria, pertussis, and inactivated poliovirus manufactured outside of the U.S." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.nhsinform.scot/healthy-living/immunisation/vaccines/the-4-in-1-vaccine" ;
    a owl:Class ;
    rdfs:comment "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    rdfs:label "TDAP/IPV vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0003180, obo:VO_0003444, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:unionOf (obo:NCBITaxon_12080
                obo:NCBITaxon_12083
                obo:NCBITaxon_12086
            )
        ]
    ] .

obo:VO_0003319
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854941" ;
    obo:VO_0003198 854941 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 15B vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003220 .

obo:VO_0003320
    obo:IAO_0000117 "Oliver He, Khadeejah Khan" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854943" ;
    obo:VO_0003198 854943 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 17F vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003221 .

obo:VO_0003321
    obo:IAO_0000117 "Oliver He, Khadeejah Khan" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854945" ;
    obo:VO_0003198 854945 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 18C vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003222 .

obo:VO_0003322
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854947" ;
    obo:VO_0003198 854947 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 19A vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003223 .

obo:VO_0003323
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854931" ;
    obo:VO_0003198 854931 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 1 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003212 .

obo:VO_0003324
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854949" ;
    obo:VO_0003198 854949 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 19F vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003224 .

obo:VO_0003325
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854951" ;
    obo:VO_0003198 854951 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 2 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003225 .

obo:VO_0003326
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854953" ;
    obo:VO_0003198 854953 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 20 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003226 .

obo:VO_0003327
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854955" ;
    obo:VO_0003198 854955 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 22F vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003227 .

obo:VO_0003328
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854959" ;
    obo:VO_0003198 854959 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 3 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003248 .

obo:VO_0003329
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854961" ;
    obo:VO_0003198 854961 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 33F vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003249 .

obo:VO_0003330
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854963" ;
    obo:VO_0003198 854963 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 4 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003232 .

obo:VO_0003331
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854971" ;
    obo:VO_0003198 854971 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 8 vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003246 .

obo:VO_0003332
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854973" ;
    obo:VO_0003198 854973 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 9N vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003254 .

obo:VO_0003333
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901636" ;
    obo:VO_0003198 901636 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 7F capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003334
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901620" ;
    obo:VO_0003198 901620 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003335
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798220" ;
    obo:VO_0003198 798220 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 14 capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003336
    obo:IAO_0000115 "a vaccine-induced down-regulation gene expression that occurs in live attenuated vaccine and compared with the host system infected with live wild type virulent strain which is the parent strain of this live attenuated vaccine. " ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "live attenuated vaccine-induced down-regulated gene expression compared to infection with wild type pathogen" ;
    rdfs:subClassOf obo:VO_0000239 .

obo:VO_0003337
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798222" ;
    obo:VO_0003198 798222 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 18C capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003338
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901624" ;
    obo:VO_0003198 901624 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 19A capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003339
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798224" ;
    obo:VO_0003198 798224 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 19F capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003340
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "vhttp://purl.bioontology.org/ontology/RXNORM/798226" ;
    obo:VO_0003198 798226 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 23F capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003341
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901628" ;
    obo:VO_0003198 901628 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 3 capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003342
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798228" ;
    obo:VO_0003198 798228 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003343
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901631" ;
    obo:VO_0003198 901631 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 5 capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003344
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901633" ;
    obo:VO_0003198 901633 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 6A capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003345
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798230" ;
    obo:VO_0003198 798230 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 6B capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003346
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798232" ;
    obo:VO_0003198 798232 ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae serotype 9V capsular antigen diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0003285, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001244
    ] .

obo:VO_0003347
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593128" ;
    obo:VO_0003198 1593128 ;
    a owl:Class ;
    rdfs:label "meningococcal group B vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003066
    ] .

obo:VO_0003348
    obo:IAO_0000115 "a vaccine-induced up-regulation gene expression that occurs in live attenuated vaccine and compared with the host system infected with live wild type virulent strain which is the parent strain of this live attenuated vaccine. " ;
    obo:IAO_0000117 "YH, RR" ;
    a owl:Class ;
    rdfs:label "live attenuated vaccine-induced up-regulated gene expression compared to infection with wild type pathogen" ;
    rdfs:subClassOf obo:VO_0000569 .

obo:VO_0003349
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601397" ;
    obo:VO_0003198 1601397 ;
    a owl:Class ;
    rdfs:label "meningococcal group B vaccine 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003347 .

obo:VO_0003350
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593133" ;
    obo:VO_0003198 1593133 ;
    a owl:Class ;
    rdfs:label "meningococcal group B vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003351 .

obo:VO_0003351
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593132" ;
    obo:VO_0003198 1593132 ;
    a owl:Class ;
    rdfs:label "meningococcal group B vaccine Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0003352
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300181" ;
    obo:VO_0003198 1300181 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003201 .

obo:VO_0003353
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm094070.htm" ;
    obo:VO_0003099 "Vivotif" ;
    obo:VO_0003158 "Typhoid Vaccine Live Oral Ty21a" ;
    obo:VO_0003159 "Berna Biotech, Ltd." ;
    obo:VO_0003160 "For immunization of adults and children greater than 6 years of age against disease caused by Salmonella typhi." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf" ;
    obo:VO_0003162 103123 ;
    a owl:Class ;
    rdfs:label "Vivotif"@en ;
    rdfs:seeAlso "CVX: 25" ;
    rdfs:subClassOf obo:VO_0000671, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000687 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003354
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/762601" ;
    obo:VO_0003198 762601 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a Delayed Release Oral Capsule [Vivotif]"@en ;
    rdfs:subClassOf obo:VO_0003357 .

obo:VO_0003355
    obo:IAO_0000115 """a shortcut relation that equals to:

processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('immunization target role' and (role_of some 'MICROBE'))))))))

The domain of this relation is a vaccine. 
The range of this relation is a microbe (a bacterium, a virus, a fungus, and a parasite)""" ;
    obo:IAO_0000117 "Yongqun He" ;
    obo:IAO_0000118 "immunization against microbe", "vaccine immunization against microbe" ;
    a owl:ObjectProperty ;
    rdfs:label "immunizes against microbe" .

obo:VO_0003356
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/762602" ;
    obo:VO_0003198 762602 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a 2000000000 UNT Delayed Release Oral Capsule [Vivotif]"@en ;
    rdfs:subClassOf obo:VO_0003354 .

obo:VO_0003357
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1187406" ;
    obo:VO_0003198 1187406 ;
    a owl:Class ;
    rdfs:label "Vivotif Oral Product"@en ;
    rdfs:subClassOf obo:VO_0003353 .

obo:VO_0003358
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1187407" ;
    obo:VO_0003198 1187407 ;
    a owl:Class ;
    rdfs:label "Vivotif Pill"@en ;
    rdfs:subClassOf obo:VO_0003353 .

obo:VO_0003359
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601405" ;
    obo:VO_0003198 1601405 ;
    a owl:Class ;
    rdfs:label "meningococcal group B vaccine Prefilled Syringe [Bexsero]"@en ;
    rdfs:subClassOf obo:VO_0004851 .

obo:VO_0003360
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601231" ;
    obo:VO_0003198 1601231 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant FHBP fusion protein antigen"@en ;
    rdfs:subClassOf obo:VO_0003960, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003066
    ] .

obo:VO_0003361
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601398" ;
    obo:VO_0003198 1601398 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant FHBP fusion protein antigen 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003360 .

obo:VO_0003362
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601233" ;
    obo:VO_0003198 1601233 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant NHBA fusion protein antigen"@en ;
    rdfs:subClassOf obo:VO_0003960, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003066
    ] .

obo:VO_0003363
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601399" ;
    obo:VO_0003198 1601399 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant NHBA fusion protein antigen 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003362 .

obo:VO_0003364
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601236" ;
    obo:VO_0003198 1601236 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B strain NZ98/254 outer membrane vesicle"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003066
    ] .

obo:VO_0003365
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601400" ;
    obo:VO_0003198 1601400 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B strain NZ98/254 outer membrane vesicle 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003364 .

obo:VO_0003366
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593127" ;
    obo:VO_0003198 1593127 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen"@en ;
    rdfs:subClassOf obo:VO_0003960, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003081
    ] .

obo:VO_0003367
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593129" ;
    obo:VO_0003198 1593129 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003366 .

obo:VO_0003368
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593130" ;
    obo:VO_0003198 1593130 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003081
    ] .

obo:VO_0003369
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593131" ;
    obo:VO_0003198 1593131 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003368 .

obo:VO_0003370
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601232" ;
    obo:VO_0003198 1601232 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant NADA fusion protein antigen"@en ;
    rdfs:subClassOf obo:VO_0003960 .

obo:VO_0003371
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804187" ;
    obo:VO_0003198 804187 ;
    a owl:Class ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain"@en ;
    rdfs:subClassOf obo:VO_0000123, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000121
    ] .

obo:VO_0003372
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1876704" ;
    obo:VO_0003198 1876704 ;
    a owl:Class ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain 2000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003371 .

obo:VO_0003373
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1876705" ;
    obo:VO_0003198 1876705 ;
    a owl:Class ;
    rdfs:label "0.5 ML Yellow-Fever Virus Vaccine, 17D-204 strain 2000 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003372 .

obo:VO_0003374
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300183" ;
    obo:VO_0003198 1300183 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003202 .

obo:VO_0003375
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1162391" ;
    obo:VO_0003198 1162391 ;
    a owl:Class ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003371 .

obo:VO_0003376
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1876709" ;
    obo:VO_0003198 1876709 ;
    a owl:Class ;
    rdfs:label "Stamaril Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003139 .

obo:VO_0003377
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1876708" ;
    obo:VO_0003198 1876708 ;
    a owl:Class ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain Injection [Stamaril]"@en ;
    rdfs:subClassOf obo:VO_0003139 .

obo:VO_0003378
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1876710" ;
    obo:VO_0003198 1876710 ;
    a owl:Class ;
    rdfs:label "0.5 ML Yellow-Fever Virus Vaccine, 17D-204 strain 2000 UNT/ML Injection [Stamaril]"@en ;
    rdfs:subClassOf obo:VO_0003377 .

obo:VO_0003379
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658238" ;
    obo:VO_0003198 1658238 ;
    a owl:Class ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain Injection"@en ;
    rdfs:subClassOf obo:VO_0003371 .

obo:VO_0003380
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658239" ;
    obo:VO_0003198 1658239 ;
    a owl:Class ;
    rdfs:label "0.5 ML Yellow-Fever Virus Vaccine, 17D-204 strain 4000 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003381 .

obo:VO_0003381
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804188" ;
    obo:VO_0003198 804188 ;
    a owl:Class ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain 4000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003371 .

obo:VO_0003382
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292826" ;
    obo:VO_0003198 1292826 ;
    a owl:Class ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain 4000 UNT/ML Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003381 .

obo:VO_0003383
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798305" ;
    obo:VO_0003198 798305 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated 5 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003455 .

obo:VO_0003384
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798306" ;
    obo:VO_0003198 798306 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated"@en ;
    rdfs:subClassOf obo:VO_0003396, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000029
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000064
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000084
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003385
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798307" ;
    obo:VO_0003198 798307 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated 10 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003384 .

obo:VO_0003386
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300379" ;
    obo:VO_0003198 1300379 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003201 .

obo:VO_0003387
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300364" ;
    obo:VO_0003198 1300364 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.016 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003201 .

obo:VO_0003388
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1988801" ;
    obo:VO_0003198 1988801 ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003201 .

obo:VO_0003389
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    a owl:Class ;
    rdfs:label "Acellular Pertussis Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165 .

obo:VO_0003390
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798302" ;
    obo:VO_0003198 798302 ;
    a owl:Class ;
    rdfs:label "acellular pertussis vaccine, inactivated"@en ;
    rdfs:subClassOf obo:VO_0003389, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000084
    ] .

obo:VO_0003391
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/829893" ;
    obo:VO_0003198 829893 ;
    a owl:Class ;
    rdfs:label "acellular pertussis vaccine, inactivated 0.116 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003390 .

obo:VO_0003392
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/801826" ;
    obo:VO_0003198 801826 ;
    a owl:Class ;
    rdfs:label "acellular pertussis vaccine, inactivated 96 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003390 .

obo:VO_0003393
    obo:IAO_0000115 "A trivalent influenza vaccine contianing two A influenza strains and one B influenza strain." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.clinicalleader.com/doc/results-phase-presented-gsks-quadrivalent-influenza-vaccines-0001" ;
    a owl:Class ;
    rdfs:label "TIV Dresden"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003394
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "An inactivated quadrivalent influenza vaccine against 2 influenza A strains and 2 influenza B strains for infants 6 months up to 23 months, and if needed it can be administered to children 2 to 17 years old with compromised immune systems and those considered vulnerable and high risk.", "https://globalnews.ca/news/2254967/a-first-for-flu-season-a-new-more-robust-four-strain-vaccine/" ;
    a owl:Class ;
    rdfs:label "QIV Quebec"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003395
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/805373" ;
    obo:VO_0003198 805373 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated 30 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003455 .

obo:VO_0003396
    obo:IAO_0000115 "A clostridium tetani vaccine that consists of formaldehyde inactivated tetanospasmin (aka tetanus toxoid)." ;
    obo:IAO_0000119 "Oliver He, Hector Guzman-Orozco", "https://en.wikipedia.org/wiki/Clostridium_tetani" ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine"@en ;
    rdfs:subClassOf obo:VO_0000640 .

obo:VO_0003397
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/374054" ;
    obo:VO_0003198 374054 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003399 .

obo:VO_0003398
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/374444" ;
    obo:VO_0003198 374444 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003399 .

obo:VO_0003399
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1164846" ;
    obo:VO_0003198 1164846 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003396 .

obo:VO_0003400
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/792155" ;
    obo:VO_0003198 792155 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003399 .

obo:VO_0003401
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/801712" ;
    obo:VO_0003198 801712 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated 20 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003384 .

obo:VO_0003402
    obo:IAO_0000117 "Khadeejh khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/792156" ;
    obo:VO_0003198 792156 ;
    a owl:Class ;
    rdfs:label "0.5 ML tetanus toxoid vaccine, inactivated 20 UNT/ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003400 .

obo:VO_0003403
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/204527" ;
    obo:VO_0003198 204527 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated 10 UNT/ML Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003398 .

obo:VO_0003404
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/205262" ;
    obo:VO_0003198 205262 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated 20 UNT/ML Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003398 .

obo:VO_0003405
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/318242" ;
    obo:VO_0003198 318242 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated 8 UNT/ML Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003397 .

obo:VO_0003406
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/316782" ;
    obo:VO_0003198 316782 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated 8 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003384 .

obo:VO_0003407
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/331444" ;
    obo:VO_0003198 331444 ;
    a owl:Class ;
    rdfs:label "tetanus toxoid vaccine, inactivated 4 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003384 .

obo:VO_0003408
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798444" ;
    obo:VO_0003198 798444 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine"@en ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000028
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000083
    ] .

obo:VO_0003409
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657731" ;
    obo:VO_0003198 1657731 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003410 .

obo:VO_0003410
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1159739" ;
    obo:VO_0003198 1159739 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003408 .

obo:VO_0003411
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798447" ;
    obo:VO_0003198 798447 ;
    a owl:Class ;
    rdfs:label "0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.265 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003409 .

obo:VO_0003412
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657733" ;
    obo:VO_0003198 1657733 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injection [PedvaxHIB]"@en ;
    rdfs:subClassOf obo:VO_0003410 .

obo:VO_0003413
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798445" ;
    obo:VO_0003198 798445 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.265 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003408 .

obo:VO_0003414
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798451" ;
    obo:VO_0003198 798451 ;
    a owl:Class ;
    rdfs:label "0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.265 MG/ML Injection [PedvaxHIB]"@en ;
    rdfs:subClassOf obo:VO_0003412 .

obo:VO_0003415
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1160330" ;
    obo:VO_0003198 1160330 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003150 .

obo:VO_0003416
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798420" ;
    obo:VO_0003198 798420 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003415 .

obo:VO_0003417
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830237" ;
    obo:VO_0003198 830237 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.005 MG/ML Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003416 .

obo:VO_0003418
    a owl:Class ;
    rdfs:label "Mumps-Rubella Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000656, [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11041
            ]
        )
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ] .

obo:VO_0003419
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798425" ;
    obo:VO_0003198 798425 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003415 .

obo:VO_0003420
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798426" ;
    obo:VO_0003198 798426 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003419 .

obo:VO_0003421
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657681" ;
    obo:VO_0003198 1657681 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003415 .

obo:VO_0003422
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830243" ;
    obo:VO_0003198 830243 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003419 .

obo:VO_0003423
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798438" ;
    obo:VO_0003198 798438 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003150 .

obo:VO_0003424
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830252" ;
    obo:VO_0003198 830252 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003419 .

obo:VO_0003425
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798429" ;
    obo:VO_0003198 798429 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003419 .

obo:VO_0003426
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658149" ;
    obo:VO_0003198 1658149 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003421 .

obo:VO_0003427
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658154" ;
    obo:VO_0003198 1658154 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003421 .

obo:VO_0003428
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799447" ;
    obo:VO_0003198 1799447 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a 2000000000 UNT [Vivotif]"@en ;
    rdfs:subClassOf obo:VO_0003353 .

obo:VO_0003429
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/807271" ;
    obo:VO_0003198 807271 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated 4 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003455 .

obo:VO_0003430
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1160325" ;
    obo:VO_0003198 1160325 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003433 .

obo:VO_0003431
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798362" ;
    obo:VO_0003198 798362 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003433 .

obo:VO_0003432
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798476" ;
    obo:VO_0003198 798476 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003430 .

obo:VO_0003433
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798361" ;
    obo:VO_0003198 798361 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175"@en ;
    rdfs:subClassOf obo:VO_0000646, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000052
    ] .

obo:VO_0003434
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/803362" ;
    obo:VO_0003198 803362 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 720 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003433 .

obo:VO_0003435
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658057" ;
    obo:VO_0003198 1658057 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 Injection"@en ;
    rdfs:subClassOf obo:VO_0003430 .

obo:VO_0003436
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658065" ;
    obo:VO_0003198 1658065 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003431 .

obo:VO_0003437
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658058" ;
    obo:VO_0003198 1658058 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003435 .

obo:VO_0003438
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799445" ;
    obo:VO_0003198 1799445 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a 2000000000 UNT"@en ;
    rdfs:subClassOf obo:VO_0003446 .

obo:VO_0003439
    a owl:Class ;
    rdfs:label "Fluzone Intradermal"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003019
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003440
    obo:IAO_0000115 "A trivalent influenza vaccine containing two strains of influenza A and one strain of influenza B for use in people 18 years to 64 years for use during the 2012-2013 season.", "Kallan Roan, Oliver He", "http://www.news.sanofi.us/2014-12-12-Sanofi-Pasteur-Announces-FDA-Approval-of-Fluzone-R-Intradermal-Quadrivalent-Influenza-Vaccine-for-Adults" ;
    a owl:Class ;
    rdfs:label "Fluzone Intradermal Trivalent"@en ;
    rdfs:subClassOf obo:VO_0003439, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0003441
    obo:IAO_0000115 "Meningococcal conjugate vaccine, which contains four of the most common types of meningococcal bacteria (serogroups A, C, W, and Y), is used to prevent infection caused by meningococcal bacteria." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.everydayhealth.com/drugs/meningococcal-conjugate-vaccine" ;
    a owl:Class ;
    rdfs:label "meningococcal conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ] .

obo:VO_0003442
    obo:IAO_0000115 "A DTaP vaccine used to keep up protection (immunity) against diphtheria, tetanus (lockjaw) and pertussis (whooping cough) in children and adults who have been vaccinated for these diseases in the past." ;
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.cdc.gov/mmwr/preview/mmwrhtml/00048610.htm" ;
    a owl:Class ;
    rdfs:label "Acel-Imune"@en ;
    rdfs:subClassOf obo:VO_0000943, [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003089 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0003443
    a owl:Class ;
    rdfs:label "Typhoid Vi Polysaccharide vaccine"@en ;
    rdfs:subClassOf obo:VO_0000671, obo:VO_0001255 .

obo:VO_0003444
    obo:IAO_0000115 "This term was used by the USA VAERS system to indicate the source, which is foreign to USA here, of the vaccine." ;
    obo:IAO_0000119 "https://wonder.cdc.gov/wonder/help/vaers.html" ;
    a owl:Class ;
    rdfs:label "vaccine foreign to USA"@en ;
    rdfs:subClassOf obo:VO_0000001 .

obo:VO_0003445
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/762598" ;
    obo:VO_0003198 762598 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a 2000000000 UNT Delayed Release Oral Capsule"@en ;
    rdfs:subClassOf obo:VO_0003447 .

obo:VO_0003446
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/762595" ;
    obo:VO_0003198 762595 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a"@en ;
    rdfs:subClassOf obo:VO_0000487 .

obo:VO_0003447
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/762597" ;
    obo:VO_0003198 762597 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a Delayed Release Oral Capsule"@en ;
    rdfs:subClassOf obo:VO_0003449 .

obo:VO_0003448
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1159372" ;
    obo:VO_0003198 1159372 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a Pill"@en ;
    rdfs:subClassOf obo:VO_0000487 .

obo:VO_0003449
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1159371" ;
    obo:VO_0003198 1159371 ;
    a owl:Class ;
    rdfs:label "Typhoid Vaccine Live Ty21a Oral Product"@en ;
    rdfs:subClassOf obo:VO_0000487 .

obo:VO_0003450
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1660921" ;
    obo:VO_0003198 1660921 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0000200 .

obo:VO_0003451
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1186748" ;
    obo:VO_0003198 1186748 ;
    a owl:Class ;
    rdfs:label "Twinrix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000113 .

obo:VO_0003452
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1724009" ;
    obo:VO_0003198 1724009 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.015 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0000200 .

obo:VO_0003453
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657222" ;
    obo:VO_0003198 1657222 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Christchurch/16/2010 (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0015084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003675
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003681
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003693
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003698
    ] .

obo:VO_0003454
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798305" ;
    obo:VO_0003198 798305 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated 13.4 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003455 .

obo:VO_0003455
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798304" ;
    obo:VO_0003198 798304 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated"@en ;
    rdfs:subClassOf obo:VO_0000508, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000015
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000029
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000064
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000084
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003456
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/801709" ;
    obo:VO_0003198 801709 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated 50 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003455 .

obo:VO_0003457
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/807414" ;
    obo:VO_0003198 807414 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated 25 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003455 .

obo:VO_0003458
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658102" ;
    obo:VO_0003198 1658102 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis A Vaccine, Inactivated 50 UNT/ML Injection [Vaqta]"@en ;
    rdfs:subClassOf obo:VO_0003466 .

obo:VO_0003459
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/802012" ;
    obo:VO_0003198 802012 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine, Inactivated 50 UNT/ML [Vaqta]"@en ;
    rdfs:subClassOf obo:VO_0010745 .

obo:VO_0003460
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/836636" ;
    obo:VO_0003198 836636 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis A Vaccine, Inactivated 50 UNT/ML Prefilled Syringe [Vaqta]"@en ;
    rdfs:subClassOf obo:VO_0003465 .

obo:VO_0003461
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658106" ;
    obo:VO_0003198 1658106 ;
    a owl:Class ;
    rdfs:label "0.5 ML Hepatitis A Vaccine, Inactivated 50 UNT/ML Injection [Vaqta]"@en ;
    rdfs:subClassOf obo:VO_0003466 .

obo:VO_0003462
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1187568" ;
    obo:VO_0003198 1187568 ;
    a owl:Class ;
    rdfs:label "Vaqta Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0010745 .

obo:VO_0003463
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/836634" ;
    obo:VO_0003198 836634 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis A Vaccine, Inactivated 50 UNT/ML Prefilled Syringe [Vaqta]"@en ;
    rdfs:subClassOf obo:VO_0003465 .

obo:VO_0003464
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/253174" ;
    obo:VO_0003198 253174 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine, Inactivated"@en ;
    rdfs:subClassOf obo:VO_0000646 .

obo:VO_0003465
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/836633" ;
    obo:VO_0003198 836633 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine, Inactivated Prefilled Syringe [Vaqta]"@en ;
    rdfs:subClassOf obo:VO_0010745 .

obo:VO_0003466
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658101" ;
    obo:VO_0003198 1658101 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine, Inactivated Injection [Vaqta]"@en ;
    rdfs:subClassOf obo:VO_0003462 .

obo:VO_0003467
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658099" ;
    obo:VO_0003198 1658099 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine, Inactivated Injection"@en ;
    rdfs:subClassOf obo:VO_0003468 .

obo:VO_0003468
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1160328" ;
    obo:VO_0003198 1160328 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine, Inactivated Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003464 .

obo:VO_0003469
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657223" ;
    obo:VO_0003198 1657223 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003453 .

obo:VO_0003470
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657224" ;
    obo:VO_0003198 1657224 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003616
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003675
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003693
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003698
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003763
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003806
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003910
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0015080
    ] .

obo:VO_0003471
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658709" ;
    obo:VO_0003198 1658709 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003470 .

obo:VO_0003472
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657225" ;
    obo:VO_0003198 1657225 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003470 .

obo:VO_0003473
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1723999" ;
    obo:VO_0003198 1723999 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.015 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003470 .

obo:VO_0003474
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664468" ;
    obo:VO_0003198 1664468 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 50000000 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003470 .

obo:VO_0003475
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657130" ;
    obo:VO_0003198 1657130 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/South Australia/55/2014 (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003715
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003779
    ] .

obo:VO_0003476
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657132" ;
    obo:VO_0003198 1657132 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/South Australia/55/2014 (H3N2) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003475 .

obo:VO_0003477
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657127" ;
    obo:VO_0003198 1657127 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Brisbane/10/2010 (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0015084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003779
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003784
    ] .

obo:VO_0003478
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799398" ;
    obo:VO_0003198 1799398 ;
    a owl:Class ;
    rdfs:label "influenza A virus A/Brisbane/10/2010 (H1N1) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003477 .

obo:VO_0003479
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657226", "https://www.fludb.org/brc/fluStrainDetails.spg?strainName=B/Brisbane/60/2008&decorator=influenza" ;
    obo:VO_0003198 1657226 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Brisbane/60/2008 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003584
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003589
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003616
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003627
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003638
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003681
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003687
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003693
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003698
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003703
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003721
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003727
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003744
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003745
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003757
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003763
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003767
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003806
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003808
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003890
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003894
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003898
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003912
    ] .

obo:VO_0003480
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657227" ;
    obo:VO_0003198 1657227 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003479 .

obo:VO_0003481
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664469" ;
    obo:VO_0003198 "", 1664469 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Brisbane/60/2008 antigen 50000000 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003479 .

obo:VO_0003482
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661110" ;
    obo:VO_0003198 1661110 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003479 .

obo:VO_0003483
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801177" ;
    obo:VO_0003198 1801177 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Brisbane/60/2008 antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003479 .

obo:VO_0003484
    obo:IAO_0000118 "vaccine against Neisseriales", "vaccine against Neisseriales bacterial infection" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Neisseriaceae" ;
    a owl:Class ;
    rdfs:label "Neisseriales vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_206351
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_206351
    ] .

obo:VO_0003485
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946982" ;
    obo:VO_0003198 1946982 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Brisbane/60/2008 antigen 158000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003479 .

obo:VO_0003486
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657133" ;
    obo:VO_0003198 1657133 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Utah/9/2014 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003779
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003784
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003791
    ] .

obo:VO_0003487
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657135" ;
    obo:VO_0003198 1657135 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003486 .

obo:VO_0003488
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657228" ;
    obo:VO_0003198 1657228 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Phuket/3073/2013 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003616
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003627
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003638
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003649
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003675
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003693
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003698
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003703
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003708
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003715
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003744
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003745
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003751
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003757
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003763
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003767
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003773
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003806
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003808
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003820
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003898
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003903
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0015080
    ] .

obo:VO_0003489
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657229" ;
    obo:VO_0003198 1657229 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003488 .

obo:VO_0003490
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1660923" ;
    obo:VO_0003198 1660923 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003488 .

obo:VO_0003491
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658710" ;
    obo:VO_0003198 1658710 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Phuket/3073/2013 antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003488 .

obo:VO_0003492
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946983" ;
    obo:VO_0003198 1946983 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Phuket/3073/2013 antigen 158000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003488 .

obo:VO_0003493
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664470" ;
    obo:VO_0003198 1664470 ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Phuket/3073/2013 antigen 50000000 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003488 .

obo:VO_0003494
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Spirochaetes.", "https://en.wikipedia.org/wiki/Spirochaete" ;
    obo:IAO_0000118 "vaccine against Spirochaetes" ;
    a owl:Class ;
    rdfs:label "Spirochaetes vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_136
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_136
    ] .

obo:VO_0003495
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:VO_0003198 """NOT IN RxNorm
Empty Parent Term""" ;
    a owl:Class ;
    rdfs:label "influenza vaccines"@en ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0003496
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1116738" ;
    obo:VO_0003198 1116738 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-Christchurch-16-2010 NIB-74 (H1N1) (A-California-7-2009) strain"@en ;
    rdfs:subClassOf obo:VO_0003498 .

obo:VO_0003497
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1303851" ;
    obo:VO_0003198 1303851 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus"@en ;
    rdfs:subClassOf obo:VO_0003499, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003579
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003611
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003874
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003878
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003882
    ] .

obo:VO_0003498
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:VO_0003198 """NOT IN RxNorm
Empty Parent Term""" ;
    a owl:Class ;
    rdfs:label "Influenza A (H1N1) Virus Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003495 .

obo:VO_0003499
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:VO_0003198 """NOT IN RxNorm
Empty Parent Term""" ;
    a owl:Class ;
    rdfs:label "Influenza A (H1N1)-like Virus"@en ;
    rdfs:subClassOf obo:VO_0003495 .

obo:VO_0003500
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:VO_0003198 """NOT IN RxNorm
Empty Parent Term""" ;
    a owl:Class ;
    rdfs:label "Influenza A (H3N2)-like Virus"@en ;
    rdfs:subClassOf obo:VO_0003495 .

obo:VO_0003501
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:VO_0003198 """NOT IN RxNorm
Empty Parent Term""" ;
    a owl:Class ;
    rdfs:label "Influenza A (H3N2) Virus Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003495 .

obo:VO_0003502
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1541617" ;
    obo:VO_0003198 1541617 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-Texas-50-2012 (H3N2)-like virus"@en ;
    rdfs:subClassOf obo:VO_0003500 .

obo:VO_0003503
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1541618" ;
    obo:VO_0003198 1541618 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-Texas-50-2012 (H3N2)-like virus 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003502 .

obo:VO_0003504
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1005931" ;
    obo:VO_0003198 1005931 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-Victoria-210-2009 X-187 (H3N2) (A-Perth-16-2009) strain"@en ;
    rdfs:subClassOf obo:VO_0003501 .

obo:VO_0003505
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1005932" ;
    obo:VO_0003198 1005932 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-Victoria-210-2009 X-187 (H3N2) (A-Perth-16-2009) strain 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003504 .

obo:VO_0003506
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1111368" ;
    obo:VO_0003198 1111368 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-Victoria-210-2009 X-187 (H3N2) (A-Perth-16-2009) strain 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003504 .

obo:VO_0003507
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1304122" ;
    obo:VO_0003198 1304122 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus"@en ;
    rdfs:subClassOf obo:VO_0003500, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003579
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003611
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003874
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003878
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003882
    ] .

obo:VO_0003508
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1304300" ;
    obo:VO_0003198 1304300 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003507 .

obo:VO_0003509
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1304309" ;
    obo:VO_0003198 1304309 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003507 .

obo:VO_0003510
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1304123" ;
    obo:VO_0003198 1304123 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003507 .

obo:VO_0003511
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1303851" ;
    obo:VO_0003198 1303851 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003497 .

obo:VO_0003512
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1304299" ;
    obo:VO_0003198 1304299 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003497 .

obo:VO_0003513
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1304308" ;
    obo:VO_0003198 1304308 ;
    a owl:Class ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003497 .

obo:VO_0003514
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1005929" ;
    obo:VO_0003198 1005929 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-California-07-2009 X-179A (H1N1) strain"@en ;
    rdfs:subClassOf obo:VO_0003498 .

obo:VO_0003515
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1005930" ;
    obo:VO_0003198 1005930 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-California-07-2009 X-179A (H1N1) strain 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003514 .

obo:VO_0003516
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1111367" ;
    obo:VO_0003198 1111367 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-California-07-2009 X-179A (H1N1) strain 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003514 .

obo:VO_0003517
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1006250" ;
    obo:VO_0003198 1006250 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated A-California-07-2009 X-181 (H1N1) strain"@en ;
    rdfs:subClassOf obo:VO_0003498 .

obo:VO_0003518
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Borreliella.", "https://en.wikipedia.org/wiki/Borrelia" ;
    obo:IAO_0000118 "vaccine against Borreliella" ;
    a owl:Class ;
    rdfs:label "Borreliella vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_64895
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_64895
    ] .

obo:VO_0003519
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:VO_0003198 """NOT IN RxNorm
Empty Parent Term""" ;
    a owl:Class ;
    rdfs:label "Influenza B Virus Vaccine"@en ;
    rdfs:subClassOf obo:VO_0003495 .

obo:VO_0003520
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:VO_0003198 """NOT IN RxNorm
Empty Parent Term""" ;
    a owl:Class ;
    rdfs:label "Influenza B-like Virus"@en ;
    rdfs:subClassOf obo:VO_0003495 .

obo:VO_0003521
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1303855" ;
    obo:VO_0003198 1303855 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Wisconsin-1-2010-like virus"@en ;
    rdfs:subClassOf obo:VO_0003520, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003874
    ] .

obo:VO_0003522
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1304310" ;
    obo:VO_0003198 1304310 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Wisconsin-1-2010-like virus 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003521 .

obo:VO_0003523
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/857921" ;
    obo:VO_0003198 857921 ;
    a owl:Class ;
    rdfs:label "Influenza Virus Vaccine, Inactivated B-Brisbane-60-2008"@en ;
    rdfs:subClassOf obo:VO_0003519, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003579
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003611
    ] .

obo:VO_0003524
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/857922" ;
    obo:VO_0003198 857922 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Brisbane-60-2008-like virus 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003523 .

obo:VO_0003525
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1111369" ;
    obo:VO_0003198 1111369 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Brisbane-60-2008-like virus 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003523 .

obo:VO_0003526
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1427022" ;
    obo:VO_0003198 1427022 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Massachusetts-2-2012-like virus"@en ;
    rdfs:subClassOf obo:VO_0003520, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003579
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003611
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003878
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003882
    ] .

obo:VO_0003527
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1427023" ;
    obo:VO_0003198 1427023 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003526 .

obo:VO_0003528
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1429576" ;
    obo:VO_0003198 1429576 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003526 .

obo:VO_0003529
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1429589" ;
    obo:VO_0003198 1429589 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003526 .

obo:VO_0003530
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1543760" ;
    obo:VO_0003198 1543760 ;
    a owl:Class ;
    rdfs:label "Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 50000000 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003526 .

obo:VO_0003531
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    a owl:Class ;
    rdfs:label "Proteobacteria vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1224
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1224
    ] .

obo:VO_0003532
    a owl:Class ;
    rdfs:label "Betaproteobacteria vaccine"@en ;
    rdfs:subClassOf obo:VO_0003531, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28216
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28216
    ] .

obo:VO_0003533
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Yersiniaceae." ;
    obo:IAO_0000118 "vacccine against Yersiniaceae" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Yersiniaceae" ;
    a owl:Class ;
    rdfs:label "Yersiniaceae vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1903411
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1903411
    ] .

obo:VO_0003534
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Corynebacterium." ;
    obo:IAO_0000118 "vaccine against Corynebacterium" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Corynebacterium" ;
    a owl:Class ;
    rdfs:label "Corynebacterium vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1716
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1716
    ] .

obo:VO_0003535
    a owl:Class ;
    rdfs:label "Gammaproteobacteria vaccine"@en ;
    rdfs:subClassOf obo:VO_0003531, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1236
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1236
    ] .

obo:VO_0003536
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Bacillus." ;
    obo:IAO_0000118 "vaccine against Bacillus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Bacillus" ;
    a owl:Class ;
    rdfs:label "Bacillus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1386
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1386
    ] .

obo:VO_0003537
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Varicellovirus." ;
    obo:IAO_0000118 "vaccine against Varicellovirus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Varicellovirus" ;
    a owl:Class ;
    rdfs:label "Varicellovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10319
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10319
    ] .

obo:VO_0003538
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Papillomaviridae.", "https://en.wikipedia.org/wiki/Papillomaviridae" ;
    obo:IAO_0000118 "vaccine against Papillomaviridae" ;
    a owl:Class ;
    rdfs:label "Papillomaviridae vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_151340
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_151340
    ] .

obo:VO_0003539
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Orthopoxvirus.", "https://en.wikipedia.org/wiki/Orthopoxvirus" ;
    obo:IAO_0000118 "vaccine against Orthopoxvirus" ;
    a owl:Class ;
    rdfs:label "Orthopoxvirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10242
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10242
    ] .

obo:VO_0003540
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Orthohepadnavirus.", "https://en.wikipedia.org/wiki/Orthohepadnavirus" ;
    obo:IAO_0000118 "vaccine against Orthohepadnavirus" ;
    a owl:Class ;
    rdfs:label "Orthohepadnavirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10405
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10405
    ] .

obo:VO_0003541
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Reoviridae." ;
    obo:IAO_0000118 "vaccine against Reoviridae" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Reoviridae" ;
    a owl:Class ;
    rdfs:label "Reoviridae vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10880
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10880
    ] .

obo:VO_0003542
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Sedoreovirinae." ;
    obo:IAO_0000118 "vaccine against Sedoreovirinae" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Sedoreovirinae" ;
    a owl:Class ;
    rdfs:label "Sedoreovirinae vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_689832
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_689832
    ] .

obo:VO_0003543
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Morbillivirus." ;
    obo:IAO_0000118 "vaccine against Morbillivirus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Morbillivirus" ;
    a owl:Class ;
    rdfs:label "Morbillivirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11229
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11229
    ] .

obo:VO_0003544
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Rubulavirus." ;
    obo:IAO_0000118 "vaccine against Rubulavirus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Rubulavirus" ;
    a owl:Class ;
    rdfs:label "Rubulavirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_39744
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_39744
    ] .

obo:VO_0003545
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Lyssavirus." ;
    obo:IAO_0000118 "vaccine against Lyssavirus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Lyssavirus" ;
    a owl:Class ;
    rdfs:label "Lyssavirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11286
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11286
    ] .

obo:VO_0003546
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Flaviviridae.", "https://en.wikipedia.org/wiki/Flaviviridae" ;
    obo:IAO_0000118 "vaccine against Flaviviridae" ;
    a owl:Class ;
    rdfs:label "Flaviviridae vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11050
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11050
    ] .

obo:VO_0003547
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Enterovirus." ;
    obo:IAO_0000118 "vaccine against Enterovirus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Enterovirus" ;
    a owl:Class ;
    rdfs:label "Enterovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12059
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12059
    ] .

obo:VO_0003548
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Hepatovirus." ;
    obo:IAO_0000118 "vaccine against Hepatovirus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Hepatitis_A#Virology" ;
    a owl:Class ;
    rdfs:label "Hepatovirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12091
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12091
    ] .

obo:VO_0003549
    obo:IAO_0000115 "A vaccine that is used against an infection by a pathogen under Rubivirus." ;
    obo:IAO_0000118 "vaccine against Rubivirus" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Rubella_virus" ;
    a owl:Class ;
    rdfs:label "Rubivirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11040
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11040
    ] .

obo:VO_0003550
    a owl:Class ;
    rdfs:label "Alphaproteobacteria vaccine"@en ;
    rdfs:subClassOf obo:VO_0003531, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28211
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28211
    ] .

obo:VO_0003551
    a owl:Class ;
    rdfs:label "Enterobacterales vaccine"@en ;
    rdfs:subClassOf obo:VO_0003535, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_91347
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_91347
    ] .

obo:VO_0003552
    a owl:Class ;
    rdfs:label "Enterobacteriaceae vaccine"@en ;
    rdfs:subClassOf obo:VO_0003551, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_543
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_543
    ] .

obo:VO_0003553
    a owl:Class ;
    rdfs:label "Spirochaetia vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_203692
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_203692
    ] .

obo:VO_0003554
    a owl:Class ;
    rdfs:label "Firmicutes vaccine"@en ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1239
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1239
    ] .

obo:VO_0003555
    a owl:Class ;
    rdfs:label "Bacilli vaccine"@en ;
    rdfs:subClassOf obo:VO_0003554, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_91061
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_91061
    ] .

obo:VO_0003556
    a owl:Class ;
    rdfs:label "Lactobacillales vaccine"@en ;
    rdfs:subClassOf obo:VO_0003554 .

obo:VO_0003557
    a owl:AnnotationProperty ;
    rdfs:label "has Protegen id", "has Protegen id"@en .

obo:VO_0003558
    a owl:AnnotationProperty ;
    rdfs:label "has Protegen annotation", "has Protegen annotation"@en .

obo:VO_0003559
    obo:IAO_0000118 "Prevnar 13 (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]) 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901644" ;
    obo:VO_0003198 901644 ;
    obo:VO_0003560 "0.5 ML Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 14 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 18C capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 19A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 19F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 23F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 3 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 5 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 6A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 6B capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0088 MG/ML / Streptococcus pneumoniae serotype 7F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 9V capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML Prefilled Syringe [Prevnar 13]" ;
    a owl:Class ;
    rdfs:label "Prevnar 13 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003570 .

obo:VO_0003560
    obo:IAO_0000112 "As seen: http://purl.bioontology.org/ontology/RXNORM/901644, the RxNORM vaccine term \"Prevnar 13 vaccine 0.5 ML Prefilled Syringe\" has Preferred Name of: 0.5 ML Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 14 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 18C capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 19A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 19F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 23F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 3 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 5 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 6A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 6B capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0088 MG/ML / Streptococcus pneumoniae serotype 7F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 9V capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML Prefilled Syringe [Prevnar 13]\". In this case, the whole preferred name is annotated under the annotation property \"RxNORM Preferred Name\"." ;
    a owl:AnnotationProperty ;
    rdfs:label "RxNORM Preferred Name", "RxNORM Preferred Name"@en .

obo:VO_0003561
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854974" ;
    obo:VO_0003198 854974 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 9V vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003562
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854975" ;
    obo:VO_0003198 854975 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 9V vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003561 .

obo:VO_0003563
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1182409" ;
    obo:VO_0003198 1182409 ;
    a owl:Class ;
    rdfs:comment "CUI: C3236244", "RXAUI: 3843751", "RXN STRENGTH: 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML", "TUI: T200" ;
    rdfs:label "Pneumovax 23 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000088 .

obo:VO_0003564
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658471" ;
    obo:VO_0003198 1658471 ;
    obo:VO_0003560 "pneumococcal capsular polysaccharide type 1 vaccine / pneumococcal capsular polysaccharide type 10A vaccine / pneumococcal capsular polysaccharide type 11A vaccine / pneumococcal capsular polysaccharide type 12F vaccine / pneumococcal capsular polysaccharide type 14 vaccine / pneumococcal capsular polysaccharide type 15B vaccine / pneumococcal capsular polysaccharide type 17F vaccine / pneumococcal capsular polysaccharide type 18C vaccine / pneumococcal capsular polysaccharide type 19A vaccine / pneumococcal capsular polysaccharide type 19F vaccine / pneumococcal capsular polysaccharide type 2 vaccine / pneumococcal capsular polysaccharide type 20 vaccine / pneumococcal capsular polysaccharide type 22F vaccine / pneumococcal capsular polysaccharide type 23F vaccine / pneumococcal capsular polysaccharide type 3 vaccine / pneumococcal capsular polysaccharide type 33F vaccine / pneumococcal capsular polysaccharide type 4 vaccine / pneumococcal capsular polysaccharide type 5 vaccine / pneumococcal capsular polysaccharide type 6B vaccine / pneumococcal capsular polysaccharide type 7F vaccine / pneumococcal capsular polysaccharide type 8 vaccine / pneumococcal capsular polysaccharide type 9N vaccine / pneumococcal capsular polysaccharide type 9V vaccine Injection [Pneumovax 23]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033793", "RXAUI: 7253076", "TUI: T200" ;
    rdfs:label "Pneumovax 23 Injection"@en ;
    rdfs:subClassOf obo:VO_0003563 .

obo:VO_0003565
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Pneumovax 23 (Pneumococcal vaccine polyvalent) 0.5 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658472" ;
    obo:VO_0003198 1658472 ;
    obo:VO_0003560 "0.5 ML pneumococcal capsular polysaccharide type 1 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 10A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 11A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 12F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 14 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 15B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 17F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 18C vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 2 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 20 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 22F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 23F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 3 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 33F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 4 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 5 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 6B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 7F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 8 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9N vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9V vaccine 0.05 MG/ML Injection [Pneumovax 23]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3887855", "RXAUI: 7253077, 7253108, 7253095", "RXN STRENGTH: 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML", "TUI: T200" ;
    rdfs:label "PNEUMOVAX 23 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003564, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003575
    ] .

obo:VO_0003566
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Pneumovax 23 (Pneumococcal vaccine polyvalent) Injectable Solution" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854981" ;
    obo:VO_0003198 854981 ;
    obo:VO_0003560 "pneumococcal capsular polysaccharide type 1 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 10A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 11A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 12F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 14 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 15B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 17F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 18C vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 2 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 20 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 22F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 23F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 3 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 33F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 4 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 5 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 6B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 7F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 8 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9N vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9V vaccine 0.05 MG/ML Injectable Solution [Pneumovax 23]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1154308", "RXAUI: 2977679, 7253371, 3270831", "RXN STRENGTH: 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML", "TUI: T200" ;
    rdfs:label "PNEUMOVAX 23 vaccine Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003563, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003575
    ] .

obo:VO_0003567
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1547581" ;
    obo:VO_0003198 1547581 ;
    obo:VO_0003560 "pneumococcal capsular polysaccharide type 1 vaccine / pneumococcal capsular polysaccharide type 10A vaccine / pneumococcal capsular polysaccharide type 11A vaccine / pneumococcal capsular polysaccharide type 12F vaccine / pneumococcal capsular polysaccharide type 14 vaccine / pneumococcal capsular polysaccharide type 15B vaccine / pneumococcal capsular polysaccharide type 17F vaccine / pneumococcal capsular polysaccharide type 18C vaccine / pneumococcal capsular polysaccharide type 19A vaccine / pneumococcal capsular polysaccharide type 19F vaccine / pneumococcal capsular polysaccharide type 2 vaccine / pneumococcal capsular polysaccharide type 20 vaccine / pneumococcal capsular polysaccharide type 22F vaccine / pneumococcal capsular polysaccharide type 23F vaccine / pneumococcal capsular polysaccharide type 3 vaccine / pneumococcal capsular polysaccharide type 33F vaccine / pneumococcal capsular polysaccharide type 4 vaccine / pneumococcal capsular polysaccharide type 5 vaccine / pneumococcal capsular polysaccharide type 6B vaccine / pneumococcal capsular polysaccharide type 7F vaccine / pneumococcal capsular polysaccharide type 8 vaccine / pneumococcal capsular polysaccharide type 9N vaccine / pneumococcal capsular polysaccharide type 9V vaccine Prefilled Syringe [Pneumovax 23]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3855233", "RXAUI: 6400287", "TUI: T200" ;
    rdfs:label "PNEUMOVAX 23 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003563 .

obo:VO_0003568
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Pneumovax 23 (Pneumococcal vaccine polyvalent) 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1547582" ;
    obo:VO_0003560 "0.5 ML pneumococcal capsular polysaccharide type 1 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 10A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 11A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 12F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 14 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 15B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 17F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 18C vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 2 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 20 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 22F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 23F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 3 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 33F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 4 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 5 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 6B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 7F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 8 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9N vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9V vaccine 0.05 MG/ML Prefilled Syringe [Pneumovax 23]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3853732", "RXAUI: 7253508, 6400288, 6400291", "RXN STRENGTH: 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML / 0.05 MG/ML", "TUI: T200" ;
    rdfs:label "PNEUMOVAX 23 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003567, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003575
    ] .

obo:VO_0003569
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1177656" ;
    obo:VO_0003198 1177656 ;
    a owl:Class ;
    rdfs:comment "CUI: C3231573", "RXAUI: 3844071", "RXN STRENGTH: 0.0044 MG/ML / 0.0044 MG/ML / 0.0044 MG/ML / 0.0044 MG/ML / 0.0044 MG/ML / 0.0088 MG/ML / 0.0044 MG/ML / 0.0044 MG/ML", "TUI: T200" ;
    rdfs:label "Prevnar 13 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0001244 .

obo:VO_0003570
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901643" ;
    obo:VO_0003198 901643 ;
    obo:VO_0003560 "Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 14 capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 18C capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 19A capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 19F capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 23F capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 3 capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 5 capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 6A capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 6B capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 7F capsular antigen diphtheria CRM197 protein conjugate vaccine / Streptococcus pneumoniae serotype 9V capsular antigen diphtheria CRM197 protein conjugate vaccine Prefilled Syringe [Prevnar 13]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2746125", "RXAUI: 3060990", "TUI: T200" ;
    rdfs:label "Prevnar 13 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003569 .

obo:VO_0003571
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854967" ;
    obo:VO_0003198 854967 ;
    a owl:Class ;
    rdfs:comment "CUI: C2709771", "RXAUI: 2977666" ;
    rdfs:label "pneumococcal capsular polysaccharide type 6B vaccine 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003250 .

obo:VO_0003572
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1179526" ;
    obo:VO_0003198 1179526 ;
    a owl:Class ;
    rdfs:comment "CUI: C3233397", "RXAUI: 3844185", "TUI: T200" ;
    rdfs:label "ProQuad Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000091 .

obo:VO_0003573
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658000" ;
    obo:VO_0003198 1658000 ;
    obo:VO_0003560 "Measles Virus Vaccine Live, Enders' attenuated Edmonston strain / Mumps Virus Vaccine Live, Jeryl Lynn Strain / Rubella Virus Vaccine Live (Wistar RA 27-3 Strain) / Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain Injection [ProQuad]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033818", "RXAUI: 7252149", "TUI: T200" ;
    rdfs:label "ProQuad vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003572 .

obo:VO_0003574
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "ProQuad Measles, Mumps, Rubella, and Varicella Virus Vaccine Live 0.5 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292443" ;
    obo:VO_0003198 1292443 ;
    obo:VO_0003560 "0.5 ML Measles Virus Vaccine Live, Enders' attenuated Edmonston strain 2000 UNT/ML / Mumps Virus Vaccine Live, Jeryl Lynn Strain 40000 UNT/ML / Rubella Virus Vaccine Live (Wistar RA 27-3 Strain) 2000 UNT/ML / Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 20000 UNT/ML Injection [ProQuad]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1698231", "RXAUI: 7252150, 7250950, 7253644", "TUI: T200" ;
    rdfs:label "ProQuad vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003573, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003278
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015055
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015057
    ] .

obo:VO_0003575
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854979" ;
    obo:VO_0003198 854979 ;
    a owl:Class ;
    rdfs:comment "CUI: C2709781", "RXAUI: 2977677", "TUI: T200" ;
    rdfs:label "pneumococcal capsular polysaccharide type 1 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 10A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 11A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 12F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 14 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 15B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 17F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 18C vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19A vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 19F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 2 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 20 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 22F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 23F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 3 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 33F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 4 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 5 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 6B vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 7F vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 8 vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9N vaccine 0.05 MG/ML / pneumococcal capsular polysaccharide type 9V vaccine 0.05 MG/ML [Pneumovax 23]"@en ;
    rdfs:subClassOf obo:VO_0000088, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003269
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003309
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003310
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003311
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003312
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003313
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003314
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003319
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003320
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003321
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003322
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003323
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003324
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003325
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003326
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003327
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003328
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003329
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003330
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
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    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
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    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003562
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003571
    ] .

obo:VO_0003576
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901642" ;
    obo:VO_0003198 901642 ;
    a owl:Class ;
    rdfs:comment "CUI: C2746124", "RXAUI: 3060989", "TUI: T200" ;
    rdfs:label "Streptococcus pneumoniae serotype 1 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 14 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 18C capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 19A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 19F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 23F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 3 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 5 capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 6A capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 6B capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0088 MG/ML / Streptococcus pneumoniae serotype 7F capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML / Streptococcus pneumoniae serotype 9V capsular antigen diphtheria CRM197 protein conjugate vaccine 0.0044 MG/ML [Prevnar 13]"@en ;
    rdfs:subClassOf obo:VO_0001244, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003286
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003287
    ], [
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        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003288
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003289
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003290
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003291
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003292
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003293
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003294
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003295
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003296
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003297
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003298
    ] .

obo:VO_0003577
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292441" ;
    obo:VO_0003198 1292441 ;
    a owl:Class ;
    rdfs:comment "CUI: C2364511", "RXAUI: 4609906", "TUI: T200" ;
    rdfs:label "Measles Virus Vaccine Live, Enders' attenuated Edmonston strain 2000 UNT/ML / Mumps Virus Vaccine Live, Jeryl Lynn Strain 40000 UNT/ML / Rubella Virus Vaccine Live (Wistar RA 27-3 Strain) 2000 UNT/ML / Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 20000 UNT/ML [ProQuad]"@en ;
    rdfs:subClassOf obo:VO_0000091, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003278
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015055
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015057
    ] .

obo:VO_0003578
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658703" ;
    obo:VO_0003198 1658703 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033722", "RXAUI: 7253467", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluzone 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0015080, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003472
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ] .

obo:VO_0003579
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1427028" ;
    obo:VO_0003198 1427028 ;
    a owl:Class ;
    rdfs:comment "CUI: C3645245", "RXAUI: 5473440", "TUI: T116, T121" ;
    rdfs:label "Fluzone Quadrivalent 2013-2014 Formula"@en ;
    rdfs:subClassOf obo:VO_0003073, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003497
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003523
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003526
    ] .

obo:VO_0003580
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658712" ;
    obo:VO_0003198 1658712 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033721", "RXAUI: 7253478", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.12 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.12 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.12 MG/ML [Fluzone 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0015080, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003260
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003471
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003491
    ] .

obo:VO_0003581
    obo:IAO_0000117 "Kallan Roan, Oliver He", "http://purl.bioontology.org/ontology/RXNORM/1658713" ;
    obo:VO_0003198 1658713 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033789", "RXAUI: 7253479", "TUI: T200" ;
    rdfs:label "Fluzone 2015-2016 High-Dose vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0000079, obo:VO_0015081 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000079
            obo:VO_0015081
        )
    ] .

obo:VO_0003582
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658714" ;
    obo:VO_0003198 1658714 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.12 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.12 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.12 MG/ML Prefilled Syringe [Fluzone 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4026367", "RXAUI: 7253480, 7253494, 7707297", "TUI: T200" ;
    rdfs:label "Fluzone 2015-2016 High-Dose vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003581, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003260
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003471
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003491
    ] .

obo:VO_0003583
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Fluzone 2015-2016 45 MCG (15 MCG x 3) in 0.5 ML Injectable Suspension", "http://purl.bioontology.org/ontology/RXNORM/1658706" ;
    obo:VO_0003198 1658706 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033789", "RXAUI: 7264732, 7253470, 7264735", "TUI: T200" ;
    rdfs:label "Fluzone 2015-2016 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0015081 .

obo:VO_0003584
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801179" ;
    obo:VO_0003198 1801179 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271565", "RXAUI: 8237155", "TUI: T116, T129, T121" ;
    rdfs:label "Fluzone 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0000047, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003585
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801180" ;
    obo:VO_0003198 1801180 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271631", "RXAUI: 8237156", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.12 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.12 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.12 MG/ML [Fluzone 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003584, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003260
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003483
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003606
    ] .

obo:VO_0003586
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801182" ;
    obo:VO_0003198 1801182 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271735", "RXAUI: 8237158", "TUI: T200" ;
    rdfs:label "Fluzone 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003584 .

obo:VO_0003587
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801181" ;
    obo:VO_0003198 1801181 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271674", "RXAUI: 8237157", "TUI: T200" ;
    rdfs:label "Fluzone 2016-2017 High-Dose vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0000079, obo:VO_0003586 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000079
            obo:VO_0003586
        )
    ] .

obo:VO_0003588
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801183" ;
    obo:VO_0003198 1801183 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.12 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.12 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.12 MG/ML Prefilled Syringe [Fluzone 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4270825", "RXAUI: 8237163, 8237162, 8237159", "TUI: T200" ;
    rdfs:label "Fluzone 2016-2017 High-Dose vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003587, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003260
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003483
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003606
    ] .

obo:VO_0003589
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928340" ;
    obo:VO_0003198 1928340 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490427", "RXAUI: 9198824", "TUI: T116" ;
    rdfs:label "Fluzone 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0000047, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003600
    ] .

obo:VO_0003590
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928343" ;
    obo:VO_0003198 1928343 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490430", "RXAUI: 9198827", "TUI: T200" ;
    rdfs:label "Fluzone 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003589 .

obo:VO_0003591
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928341" ;
    obo:VO_0003198 1928341 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490428", "RXAUI: 9198825", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.12 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.12 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.12 MG/ML [Fluzone 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003589, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003483
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003604
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003606
    ] .

obo:VO_0003592
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928342" ;
    obo:VO_0003198 1928342 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490429", "RXAUI: 9198826", "TUI: T200" ;
    rdfs:label "Fluzone 2017-2018 high-dose vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0000079, obo:VO_0003590 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000079
            obo:VO_0003590
        )
    ] .

obo:VO_0003593
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928344" ;
    obo:VO_0003198 1928344 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.12 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.12 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.12 MG/ML Prefilled Syringe [Fluzone 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325062", "RXAUI: 9198828, 9198831, 9198832", "TUI: T200" ;
    rdfs:label "Fluzone 2017-2018 high-dose vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003592, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003483
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003604
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003606
    ] .

obo:VO_0003594
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050419" ;
    obo:VO_0003198 2050419 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719042", "RXAUI: 10289780", "TUI: T109" ;
    rdfs:label "Fluzone 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0000047, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003600
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ] .

obo:VO_0003595
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050422" ;
    obo:VO_0003198 2050422 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719045", "RXAUI: 10289783", "RXN STRENGTH: 0.12 MG/ML (expressed as influenza A virus A/Michigan/45/2015 (H1N1) antigen) / 0.12 MG/ML (expressed as influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen) / 0.12 MG/ML (expressed as influenza B virus B/Maryland/15/2016 antigen)", "TUI: T200" ;
    rdfs:label "Fluzone 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003594 .

obo:VO_0003596
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050420" ;
    obo:VO_0003198 2050420 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719043", "RXAUI: 10289781", "TUI: T200" ;
    rdfs:label "influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.12 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.12 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.12 MG/ML [Fluzone 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003594, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003603
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003604
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003605
    ] .

obo:VO_0003597
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050421" ;
    obo:VO_0003198 2050421 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719044", "RXAUI: 10289782", "TUI: T200" ;
    rdfs:label "Fluzone 2018-2019 high-dose vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0000079, obo:VO_0003595, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003603
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003604
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003605
    ] ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000079
            obo:VO_0003595
        )
    ] .

obo:VO_0003598
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050423" ;
    obo:VO_0003198 2050423 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.12 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.12 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.12 MG/ML Prefilled Syringe [Fluzone 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719046", "RXAUI: 10289784, 10289785, 10289786", "TUI: T200" ;
    rdfs:label "Fluzone 2018-2019 high-dose vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003597 .

obo:VO_0003599
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1794331" ;
    obo:VO_0003198 1794331 ;
    a owl:Class ;
    rdfs:comment "CUI: C4256803", "RXAUI: 8222490", "TUI: T116, T129, T121" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003584
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003589
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003627
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003638
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003681
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003687
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003698
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003703
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003721
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003727
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003744
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003745
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003757
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003767
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003784
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003890
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003894
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003898
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003911
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003912
    ] .

obo:VO_0003600
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928289" ;
    obo:VO_0003198 1928289 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490394", "RXAUI: 9198755", "TUI: T116, T129, T121" ;
    rdfs:label "influenza A virus A/Michigan/45/2015 (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0015084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003589
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003594
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003638
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003649
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003894
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003898
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003903
    ] .

obo:VO_0003601
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048564" ;
    obo:VO_0003198 2048564 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704008", "RXAUI: 10279285", "TUI: T116, T129, T121" ;
    rdfs:label "influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003594
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003649
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003687
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003708
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003733
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003751
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003773
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003791
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003820
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003903
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003913
    ] .

obo:VO_0003602
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048563" ;
    obo:VO_0003198 2048563 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704007", "RXAUI: 10279284", "TUI: T116, T129, T121" ;
    rdfs:label "influenza B virus B/Maryland/15/2016 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003594
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003649
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003708
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003733
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003751
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003773
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003903
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003913
    ] .

obo:VO_0003603
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050417" ;
    obo:VO_0003198 2050417 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719040", "RXAUI: 10289778", "RXN STRENGTH: 0.12 MG/ML", "TUI: T200" ;
    rdfs:label "influenza B virus B/Maryland/15/2016 antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003602 .

obo:VO_0003604
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928338" ;
    obo:VO_0003198 1928338 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490425", "RXAUI: 9198822", "RXN STRENGTH: 0.12 MG/ML", "TUI: T200" ;
    rdfs:label "influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003600 .

obo:VO_0003605
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050416" ;
    obo:VO_0003198 2050416 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719039", "RXAUI: 10289777", "RXN STRENGTH: 0.12 MG/ML", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003601 .

obo:VO_0003606
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801176" ;
    obo:VO_0003198 1801176 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271783", "RXAUI: 8237152", "RXN STRENGTH: 0.12 MG/ML", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003599 .

obo:VO_0003607
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1427031" ;
    obo:VO_0003198 1427031 ;
    a owl:Class ;
    rdfs:comment "CUI: C3645248", "RXAUI: 5473443", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2013-2014 Formula Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003579 .

obo:VO_0003608
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1427029" ;
    obo:VO_0003198 1427029 ;
    a owl:Class ;
    rdfs:comment "CUI: C3645246", "RXAUI: 5473441", "TUI: T200" ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.03 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.03 MG/ML / Influenza B virus vaccine, B-Brisbane-60-2008-like virus 0.03 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.03 MG/ML [Fluzone Quadrivalent 2013-2014 Formula]"@en ;
    rdfs:subClassOf obo:VO_0003579, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003510
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003511
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003524
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003527
    ] .

obo:VO_0003609
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1427038" ;
    obo:VO_0003198 1427038 ;
    obo:VO_0003560 "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus / Influenza B virus vaccine, B-Brisbane-60-2008-like virus / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus Prefilled Syringe [Fluzone Quadrivalent 2013-2014 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3645252", "RXAUI: 5473453", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2013-2014 Formula Influenza Virus Vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003607 .

obo:VO_0003610
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1427052" ;
    obo:VO_0003198 1427052 ;
    obo:VO_0003560 "0.25 ML Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.03 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.03 MG/ML / Influenza B virus vaccine, B-Brisbane-60-2008-like virus 0.03 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2013-2014 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3537276", "RXAUI: 5488148, 5473470, 5473464", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2013-2014 Formula Influenza Virus Vaccine 0.25 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003609, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003510
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003511
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003524
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003527
    ] .

obo:VO_0003611
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1537557" ;
    obo:VO_0003198 1537557 ;
    a owl:Class ;
    rdfs:comment "CUI: C3817309", "RXAUI: 6338534", "TUI: T116, T121" ;
    rdfs:label "Fluzone Quadrivalent 2014-2015 Formula"@en ;
    rdfs:subClassOf obo:VO_0003073, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003497
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003523
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003526
    ] .

obo:VO_0003612
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1537560" ;
    obo:VO_0003198 1537560 ;
    a owl:Class ;
    rdfs:comment "CUI: C3819823", "RXAUI: 6338537", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2014-2015 Formula Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003611 .

obo:VO_0003613
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1598360" ;
    obo:VO_0003198 1598360 ;
    a owl:Class ;
    rdfs:comment "CUI: C3872179", "RXAUI: 6821895", "TUI: T200" ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Brisbane-60-2008-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.09 MG/ML [Fluzone Quadrivalent 2014-2015 Formula]"@en ;
    rdfs:subClassOf obo:VO_0003611, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003509
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003513
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003525
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003528
    ] .

obo:VO_0003614
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1537559" ;
    obo:VO_0003198 1537559 ;
    obo:VO_0003560 "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus / Influenza B virus vaccine, B-Brisbane-60-2008-like virus / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus Prefilled Syringe [Fluzone Quadrivalent 2014-2015 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3819658", "RXAUI: 6338536", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2014-2015 Formula Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003612 .

obo:VO_0003615
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1598361" ;
    obo:VO_0003198 1598361 ;
    obo:VO_0003560 "0.1 ML Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Brisbane-60-2008-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.09 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2014-2015 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3871481", "RXAUI: 6821896, 6821899", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2014-2015 Formula 0.1 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003614, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003613
    ] .

obo:VO_0003616
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659725" ;
    obo:VO_0003198 1659725 ;
    a owl:Class ;
    rdfs:comment "CUI: C4026655", "RXAUI: 7255357", "TUI: T116, T129, T121" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0003073, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ] .

obo:VO_0003617
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659728" ;
    obo:VO_0003198 1659728 ;
    a owl:Class ;
    rdfs:comment "CUI: C4047088", "RXAUI: 7255360", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003616 .

obo:VO_0003618
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659726" ;
    obo:VO_0003198 1659726 ;
    a owl:Class ;
    rdfs:comment "CUI: C4046959", "RXAUI: 7255358", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluzone Quadrivalent 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003616, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003472
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ] .

obo:VO_0003619
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661112" ;
    obo:VO_0003198 1661112 ;
    a owl:Class ;
    rdfs:comment "CUI: C4046937", "RXAUI: 7258293", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML [Fluzone Quadrivalent 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003616, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003450
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003482
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003490
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003658
    ] .

obo:VO_0003620
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659747" ;
    obo:VO_0003198 1659747 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Injection [Fluzone Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4047035", "RXAUI: 7255391", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 Injection"@en ;
    rdfs:subClassOf obo:VO_0003617 .

obo:VO_0003621
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659748" ;
    obo:VO_0003198 1659748 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injection [Fluzone Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4046210", "RXAUI: 7255392, 7707326", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003620, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003618
    ] .

obo:VO_0003622
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659729" ;
    obo:VO_0003198 1659729 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Fluzone Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4018869", "RXAUI: 7707300, 7255361", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003617, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003618
    ] .

obo:VO_0003623
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659736" ;
    obo:VO_0003198 1659736 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4047037", "RXAUI: 7255373", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003617 .

obo:VO_0003624
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661113" ;
    obo:VO_0003198 1661113 ;
    obo:VO_0003560 "0.1 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4032740", "RXAUI: 7707304, 7258294", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 vaccine 0.1 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003623, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003619
    ] .

obo:VO_0003625
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659755" ;
    obo:VO_0003198 1659755 ;
    obo:VO_0003560 "0.25 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4026368", "RXAUI: 7255401, 7707633", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 vaccine 0.25 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003623, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003618
    ] .

obo:VO_0003626
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659737" ;
    obo:VO_0003198 1659737 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4046211", "RXAUI: 7707379, 7255374", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2015-2016 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003623, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003618
    ] .

obo:VO_0003627
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801071" ;
    obo:VO_0003198 1801071 ;
    a owl:Class ;
    rdfs:comment "CUI: C4224224", "RXAUI: 8236907", "TUI: T116, T129, T121" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0003073, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003628
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801074" ;
    obo:VO_0003198 1801074 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271738", "RXAUI: 8236910", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003627 .

obo:VO_0003629
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801173" ;
    obo:VO_0003198 1801173 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271632", "RXAUI: 8237145", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluzone Quadrivalent 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003627, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ] .

obo:VO_0003630
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801072" ;
    obo:VO_0003198 1801072 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271637", "RXAUI: 8236908", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML [Fluzone Quadrivalent 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003627, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003450
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003482
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003490
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003660
    ] .

obo:VO_0003631
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801188" ;
    obo:VO_0003198 1801188 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Injection [Fluzone Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271673", "RXAUI: 8237172", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 Formula Injection"@en ;
    rdfs:subClassOf obo:VO_0003628 .

obo:VO_0003632
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801189" ;
    obo:VO_0003198 1801189 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injection [Fluzone Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4270930", "RXAUI: 8237177, 8237176, 8237173", "RXN STRENGTH: 0.03 MG/ML (expressed as influenza A virus A/California/7/2009 (H1N1) antigen) / 0.03 MG/ML (expressed as influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen) / 0.03 MG/ML (expressed as influenza B virus B/Brisbane/60/2008 antigen) / 0.03 MG/ML (expressed as influenza B virus B/Phuket/3073/2013 antigen)", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 Formula 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003631, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003629
    ] .

obo:VO_0003633
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801193" ;
    obo:VO_0003198 1801193 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Fluzone Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224210", "RXAUI: 8237184, 8237186, 8237185", "RXN STRENGTH: 0.03 MG/ML (expressed as influenza A virus A/California/7/2009 (H1N1) antigen) / 0.03 MG/ML (expressed as influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen) / 0.03 MG/ML (expressed as influenza B virus B/Brisbane/60/2008 antigen) / 0.03 MG/ML (expressed as influenza B virus B/Phuket/3073/2013 antigen)", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003629
    ] .

obo:VO_0003634
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801073" ;
    obo:VO_0003198 1801073 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271678", "RXAUI: 8236909", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003628 .

obo:VO_0003635
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801075" ;
    obo:VO_0003198 1801075 ;
    obo:VO_0003560 "0.1 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4270829", "RXAUI: 8236914, 8237166, 8236911", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 vaccine 0.1 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003634, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003630
    ] .

obo:VO_0003636
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801174" ;
    obo:VO_0003198 1801174 ;
    obo:VO_0003560 "0.25 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224209", "RXAUI: 8237169, 8237148, 8237146", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 vaccine 0.25 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003634, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003629
    ] .

obo:VO_0003637
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801186" ;
    obo:VO_0003198 1801186 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4270931", "RXAUI: 8237168, 8237167, 8237165", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2016-2017 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003634, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003629
    ] .

obo:VO_0003638
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928313" ;
    obo:VO_0003198 1928313 ;
    a owl:Class ;
    rdfs:comment "CUI: C4325215", "RXAUI: 9198781", "TUI: T116, T129, T121" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0003073, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003600
    ] .

obo:VO_0003639
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928316" ;
    obo:VO_0003198 1928316 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490411", "RXAUI: 9198784", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003638 .

obo:VO_0003640
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928314" ;
    obo:VO_0003198 1928314 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490409", "RXAUI: 9198782", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluzone Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003638, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003661
    ] .

obo:VO_0003641
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928469" ;
    obo:VO_0003198 1928469 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490475", "RXAUI: 9199188", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML [Fluzone Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003638, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003482
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003490
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003660
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003662
    ] .

obo:VO_0003642
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928315" ;
    obo:VO_0003198 1928315 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Injection [Fluzone Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490410", "RXAUI: 9198783", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003639 .

obo:VO_0003643
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928317" ;
    obo:VO_0003198 1928317 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injection [Fluzone Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490412", "RXAUI: 9198785, 9198856, 9198855", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003640
    ] .

obo:VO_0003644
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928356" ;
    obo:VO_0003198 1928356 ;
    obo:VO_0003560 "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Fluzone Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4319521", "RXAUI: 9198884, 9198850, 9198885", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003639, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003640
    ] .

obo:VO_0003645
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928331" ;
    obo:VO_0003198 1928331 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490420", "RXAUI: 9198810", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003639 .

obo:VO_0003646
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928359" ;
    obo:VO_0003198 1928359 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490439", "RXAUI: 9198872, 9198871, 9198873", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003645, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003640
    ] .

obo:VO_0003647
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928332" ;
    obo:VO_0003198 1928332 ;
    obo:VO_0003560 "0.25 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325067", "RXAUI: 9198880, 9198881, 9198811", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 vaccine 0.25 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003645, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003640
    ] .

obo:VO_0003648
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928470" ;
    obo:VO_0003198 1928470 ;
    obo:VO_0003560 "0.1 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325068", "RXAUI: 9199192, 9199191, 9199189", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2017-2018 vaccine 0.1 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003645, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003641
    ] .

obo:VO_0003649
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050773" ;
    obo:VO_0003198 2050773 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719179", "RXAUI: 10290520", "TUI: T116, T129, T121" ;
    rdfs:label "Fluzone Quadrivalent 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0003073, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003600
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ] .

obo:VO_0003650
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050776" ;
    obo:VO_0003198 2050776 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719182", "RXAUI: 10290523", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003649 .

obo:VO_0003651
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050774" ;
    obo:VO_0003198 2050774 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719180", "RXAUI: 10290521", "TUI: T200" ;
    rdfs:label "influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluzone Quadrivalent 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003649, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003661
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003664
    ] .

obo:VO_0003652
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050781" ;
    obo:VO_0003198 2050781 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Injection [Fluzone Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719187", "RXAUI: 10290530", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2018-2019 vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003650 .

obo:VO_0003653
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050782" ;
    obo:VO_0003198 2050782 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injection [Fluzone Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719188", "RXAUI: 10290531, 10290534, 10290535", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2018-2019 vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003652, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003651
    ] .

obo:VO_0003654
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050787" ;
    obo:VO_0003198 2050787 ;
    obo:VO_0003560 "influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Fluzone Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4553813", "RXAUI: 10290540, 10290538, 10290539", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2018-2019 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003650, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003651
    ] .

obo:VO_0003655
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050775" ;
    obo:VO_0003198 2050775 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluzone Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719181", "RXAUI: 10290522", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2018-2019 Vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003650 .

obo:VO_0003656
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050789" ;
    obo:VO_0003198 2050789 ;
    obo:VO_0003560 "0.25 ML influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719194", "RXAUI: 10290543, 10290544, 10290545", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent Pediatric Dose for 6-35 Months of Age 2018-2019 Vaccine 0.25 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003655, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003651
    ] .

obo:VO_0003657
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050777" ;
    obo:VO_0003198 2050777 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluzone Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "RXAUI: 10290524, 10290528, 10290527", "TUI: T200" ;
    rdfs:label "Fluzone Quadrivalent 2018-2019 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003655, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003651
    ] ;
    owl:priorVersion "CUI: C4719183" .

obo:VO_0003658
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1660922" ;
    obo:VO_0003198 1660922 ;
    a owl:Class ;
    rdfs:comment "CUI: C4047148", "RXAUI: 7258095", "TUI: T200" ;
    rdfs:label "influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003470 .

obo:VO_0003659
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1794431" ;
    obo:VO_0003198 1794431 ;
    a owl:Class ;
    rdfs:comment "CUI: C4257282", "RXAUI: 8222590", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003599 .

obo:VO_0003660
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801069" ;
    obo:VO_0003198 1801069 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271787", "RXAUI: 8236905", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003599 .

obo:VO_0003661
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928310" ;
    obo:VO_0003198 1928310 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490406", "RXAUI: 9198778", "TUI: T200" ;
    rdfs:label "influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003600 .

obo:VO_0003662
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928291" ;
    obo:VO_0003198 1928291 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490396", "RXAUI: 9198757", "TUI: T200" ;
    rdfs:label "influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003600 .

obo:VO_0003663
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048958" ;
    obo:VO_0003198 2048958 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704185", "RXAUI: 10279935", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003601 .

obo:VO_0003664
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048959" ;
    obo:VO_0003198 2048959 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704186", "RXAUI: 10279936", "TUI: T200" ;
    rdfs:label "influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003602 .

obo:VO_0003665
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "RXAUI: 3850144", "http://purl.bioontology.org/ontology/RXNORM/1186641" ;
    obo:VO_0003198 1186641 ;
    a owl:Class ;
    rdfs:comment "CUI: C3240393", "TUI: T200" ;
    rdfs:label "YF-Vax Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000121 .

obo:VO_0003666
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:VO_0003198 1658240 ;
    obo:VO_0003560 "Yellow-Fever Virus Vaccine, 17D-204 strain Injection [YF-Vax]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033799", "RXAUI: 7252581", "TUI: T200" ;
    rdfs:label "YF-VAX Injection"@en ;
    rdfs:subClassOf obo:VO_0003665 .

obo:VO_0003667
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "0.5 ML YF-Vax 4000 UNT/ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658241" ;
    obo:VO_0003198 1658241 ;
    obo:VO_0003560 "0.5 ML Yellow-Fever Virus Vaccine, 17D-204 strain 4000 UNT/ML Injection [YF-Vax]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4019051", "RXAUI: 7252591, 7252583, 7252590, 7252582", "TUI: T200" ;
    rdfs:label "YF-VAX 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003666, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003381
    ] .

obo:VO_0003668
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292828" ;
    obo:VO_0003198 1292828 ;
    obo:VO_0003560 "YF-Vax 4000 UNT/ML Injectable Suspension" ;
    a owl:Class ;
    rdfs:comment "CUI: C0710788", "RXAUI: 4610776, 4610775, 7251861", "TUI: T200" ;
    rdfs:label "YF-Vax 4000 UNT/ML Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003669, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003381
    ] .

obo:VO_0003669
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292827" ;
    obo:VO_0003198 1292827 ;
    obo:VO_0003560 "Yellow-Fever Virus Vaccine, 17D-204 strain Injectable Suspension [YF-Vax]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2356379", "RXAUI: 4610774", "TUI: T200" ;
    rdfs:label "YF-Vax Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003665 .

obo:VO_0003670
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804191" ;
    obo:VO_0003198 804191 ;
    a owl:Class ;
    rdfs:comment "CUI: C2356378", "RXAUI: 2860284", "TUI: T200" ;
    rdfs:label "Yellow-Fever Virus Vaccine, 17D-204 strain 4000 UNT/ML [YF-Vax]"@en ;
    rdfs:subClassOf obo:VO_0003665, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003381
    ] .

obo:VO_0003671
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1184551" ;
    obo:VO_0003198 1184551 ;
    a owl:Class ;
    rdfs:comment "CUI: C3238354", "RXAUI: 3843231", "TUI: T200" ;
    rdfs:label "PedvaxHIB Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000083 .

obo:VO_0003672
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798449" ;
    obo:VO_0003198 798449 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344386", "RXAUI: 2851572", "TUI: T200" ;
    rdfs:label "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.265 MG/ML [PedvaxHIB]"@en ;
    rdfs:subClassOf obo:VO_0000083 .

obo:VO_0003673
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657733" ;
    obo:VO_0003198 1657733 ;
    obo:VO_0003560 "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injection [PedvaxHIB]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033832", "RXAUI: 7251648", "TUI: T200" ;
    rdfs:label "PedvaxHIB vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003671 .

obo:VO_0003674
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798451" ;
    obo:VO_0003198 798451 ;
    obo:VO_0003560 "0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.265 MG/ML Injection [PedvaxHIB]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1237239", "RXAUI: 7251650, 7251649, 7253595, 7251196", "TUI: T200" ;
    rdfs:label "PedvaxHIB vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003673, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003413
    ] .

obo:VO_0003675
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657326" ;
    obo:VO_0003198 1657326 ;
    a owl:Class ;
    rdfs:comment "CUI: C4026630", "RXAUI: 7251220", "TUI: T116, T129, T121" ;
    rdfs:label "Fluvirin 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0000046, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003453
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ] .

obo:VO_0003676
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657329" ;
    obo:VO_0003198 1657329 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033912", "RXAUI: 7251223", "TUI: T200" ;
    rdfs:label "Fluvirin 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003675 .

obo:VO_0003677
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657327" ;
    obo:VO_0003198 1657327 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033751", "RXAUI: 7251221", "TUI: T200" ;
    rdfs:label "influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluvirin 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003675, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003469
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003472
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ] .

obo:VO_0003678
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657330" ;
    obo:VO_0003198 1657330 ;
    obo:VO_0003560 "influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Fluvirin 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4026364", "RXAUI: 7251224, 7251264", "TUI: T200" ;
    rdfs:label "Fluvirin 2015-2016 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003676, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003677
    ] .

obo:VO_0003679
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659982" ;
    obo:VO_0003198 1659982 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluvirin 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4047024", "RXAUI: 7255800", "TUI: T200" ;
    rdfs:label "Fluvirin 2015-2016 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003676 .

obo:VO_0003680
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659983" ;
    obo:VO_0003198 1659983 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluvirin 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4026365", "RXAUI: 7255801, 7255804", "TUI: T200" ;
    rdfs:label "Fluvirin 2015-2016 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003679, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003677
    ] .

obo:VO_0003681
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801153" ;
    obo:VO_0003198 1801153 ;
    a owl:Class ;
    rdfs:comment "CUI: C4224219", "RXAUI: 8237127", "TUI: T116, T129, T121" ;
    rdfs:label "Fluvirin 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0000046, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003453
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003682
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801156" ;
    obo:VO_0003198 1801156 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271736", "RXAUI: 8237130", "TUI: T200" ;
    rdfs:label "Fluvirin 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003681 .

obo:VO_0003683
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801154" ;
    obo:VO_0003198 1801154 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271633", "RXAUI: 8237128", "TUI: T200" ;
    rdfs:label "influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML [Fluvirin 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003681, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003469
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ] .

obo:VO_0003684
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801157" ;
    obo:VO_0003198 1801157 ;
    obo:VO_0003560 "influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Injectable Suspension [Fluvirin 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224195", "RXAUI: 8237131, 8237133, 8237132", "TUI: T200" ;
    rdfs:label "Fluvirin 2016-2017 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003682, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003683
    ] .

obo:VO_0003685
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801162" ;
    obo:VO_0003198 1801162 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluvirin 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271675", "RXAUI: 8237137", "TUI: T200" ;
    rdfs:label "Fluvirin 2016-2017 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003682 .

obo:VO_0003686
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801163" ;
    obo:VO_0003198 1801163 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Prefilled Syringe [Fluvirin 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4270826", "RXAUI: 8237141, 8237142, 8237138", "TUI: T200" ;
    rdfs:label "Fluvirin 2016-2017 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003685, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003683
    ] .

obo:VO_0003687
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928970" ;
    obo:VO_0003198 1928970 ;
    a owl:Class ;
    rdfs:comment "CUI: C4325210", "RXAUI: 9199995", "TUI: T116, T129, T121" ;
    rdfs:label "Fluvirin 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0000046, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ] .

obo:VO_0003688
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928973" ;
    obo:VO_0003198 1928973 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490746", "RXAUI: 9199998", "TUI: T200" ;
    rdfs:label "Fluvirin 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003687 .

obo:VO_0003689
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928971" ;
    obo:VO_0003198 1928971 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490744", "RXAUI: 9199996", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML [Fluvirin 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003687, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ] .

obo:VO_0003690
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928974" ;
    obo:VO_0003198 1928974 ;
    obo:VO_0003560 "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Injectable Suspension [Fluvirin 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325059", "RXAUI: 9200000, 9199999, 9200001", "TUI: T200" ;
    rdfs:label "Fluvirin 2017-2018 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003688, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003689
    ] .

obo:VO_0003691
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928978" ;
    obo:VO_0003198 1928978 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluvirin 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490747", "RXAUI: 9200007", "TUI: T200" ;
    rdfs:label "Fluvirin 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003688 .

obo:VO_0003692
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928982" ;
    obo:VO_0003198 1928982 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Prefilled Syringe [Fluvirin 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325061", "RXAUI: 9200013, 9200018, 9200017", "TUI: T200" ;
    rdfs:label "Fluvirin 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003691, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003689
    ] .

obo:VO_0003693
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657232" ;
    obo:VO_0003198 1657232 ;
    a owl:Class ;
    rdfs:comment "CUI: C4026648", "RXAUI: 7251209", "TUI: T116, T129, T121" ;
    rdfs:label "Fluarix Quadrivalent 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0000983, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003453
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ] .

obo:VO_0003694
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657235" ;
    obo:VO_0003198 1657235 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033913", "RXAUI: 7251212", "TUI: T200" ;
    rdfs:label "Fluarix Quadrivalent 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003693 .

obo:VO_0003695
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657233" ;
    obo:VO_0003198 1657233 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033752", "RXAUI: 7251210", "TUI: T200" ;
    rdfs:label "influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluarix Quadrivalent 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003693, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003469
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003472
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ] .

obo:VO_0003696
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657234" ;
    obo:VO_0003198 1657234 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluarix Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033850", "RXAUI: 7251211", "TUI: T200" ;
    rdfs:label "FLUARIX QUADRIVALENT 2015-2016 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003694 .

obo:VO_0003697
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657236" ;
    obo:VO_0003198 1657236 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluarix Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4026362", "RXAUI: 7707241, 7251213", "TUI: T200" ;
    rdfs:label "FLUARIX QUADRIVALENT 2015-2016 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003696, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003695
    ] .

obo:VO_0003698
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799119" ;
    obo:VO_0003198 1799119 ;
    a owl:Class ;
    rdfs:comment "CUI: C4224221", "RXAUI: 8233865", "TUI: T116, T129, T121" ;
    rdfs:label "Fluarix Quadrivalent 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0000983, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003453
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003699
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799122" ;
    obo:VO_0003198 1799122 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271754", "RXAUI: 8233868", "TUI: T200" ;
    rdfs:label "Fluarix Quadrivalent 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003698 .

obo:VO_0003700
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799120" ;
    obo:VO_0003198 1799120 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271658", "RXAUI: 8233866", "TUI: T200" ;
    rdfs:label "influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluarix Quadrivalent 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003698, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003469
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ] .

obo:VO_0003701
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799121" ;
    obo:VO_0003198 1799121 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluarix Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271699", "RXAUI: 8233867", "TUI: T200" ;
    rdfs:label "FLUARIX QUADRIVALENT 2016-2017 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003699 .

obo:VO_0003702
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799123" ;
    obo:VO_0003198 1799123 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Christchurch/16/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluarix Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224206", "RXAUI: 8233903, 8233902, 8233869", "TUI: T200" ;
    rdfs:label "FLUARIX QUADRIVALENT 2016-2017 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003701, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003700
    ] .

obo:VO_0003703
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928303" ;
    obo:VO_0003198 1928303 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490400", "RXAUI: 9198769", "TUI: T116, T129, T121" ;
    rdfs:label "Fluarix Quadrivalent 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0000983, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003704
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928306" ;
    obo:VO_0003198 1928306 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490403", "RXAUI: 9198772", "TUI: T200" ;
    rdfs:label "Fluarix Quadrivalent 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003703 .

obo:VO_0003705
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928304" ;
    obo:VO_0003198 1928304 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490401", "RXAUI: 9198770", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluarix Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003703, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003706
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928305" ;
    obo:VO_0003198 1928305 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluarix Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490402", "RXAUI: 9198771", "TUI: T200" ;
    rdfs:label "Fluarix Quadrivalent 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003704 .

obo:VO_0003707
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928307" ;
    obo:VO_0003198 1928307 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluarix Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325064", "RXAUI: 9198814, 9198808, 9198773", "TUI: T200" ;
    rdfs:label "Fluarix Quadrivalent 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003706, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003705
    ] .

obo:VO_0003708
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048962" ;
    obo:VO_0003198 2048962 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704189", "RXAUI: 10279939", "TUI: T116, T129, T121" ;
    rdfs:label "Fluarix Quadrivalent 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0000983, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003709
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048965" ;
    obo:VO_0003198 2048965 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704192", "RXAUI: 10279942", "TUI: T200" ;
    rdfs:label "Fluarix Quadrivalent 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003708 .

obo:VO_0003710
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048963" ;
    obo:VO_0003198 2048963 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704190", "RXAUI: 10279940", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Fluarix Quadrivalent 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003708, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003664
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003711
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048964" ;
    obo:VO_0003198 2048964 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluarix Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4704191", "RXAUI: 10279941", "TUI: T200" ;
    rdfs:label "FLUARIX QUADRIVALENT 2018-2019 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003709 .

obo:VO_0003712
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048966" ;
    obo:VO_0003198 2048966 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Fluarix Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4704193", "RXAUI: 10279943, 10279945, 10279944", "TUI: T200" ;
    rdfs:label "FLUARIX QUADRIVALENT 2018-2019 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003711 .

obo:VO_0003713
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928290" ;
    obo:VO_0003198 1928290 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490395", "RXAUI: 9198756", "TUI: T116, T129, T121" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0015084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003703
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003708
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003727
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003733
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003745
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003751
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003767
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003773
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003791
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003913
    ] .

obo:VO_0003714
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928300" ;
    obo:VO_0003198 1928300 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490397", "RXAUI: 9198766", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003713 .

obo:VO_0003715
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661803" ;
    obo:VO_0003198 1661803 ;
    a owl:Class ;
    rdfs:comment "CUI: C4020099", "RXAUI: 7264715", "TUI: T129, T121" ;
    rdfs:label "Afluria 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0000006, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003475
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ] .

obo:VO_0003716
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661806" ;
    obo:VO_0003198 1661806 ;
    a owl:Class ;
    rdfs:comment "CUI: C4047061", "RXAUI: 7264718", "TUI: T200" ;
    rdfs:label "Afluria 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003715 .

obo:VO_0003717
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661804" ;
    obo:VO_0003198 1661804 ;
    a owl:Class ;
    rdfs:comment "CUI: C4046916", "RXAUI: 7264716", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/South Australia/55/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Afluria 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003715, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003476
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ] .

obo:VO_0003718
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661812" ;
    obo:VO_0003198 1661812 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/South Australia/55/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Afluria 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4018775", "RXAUI: 7264729, 7707306, 7264733", "TUI: T200" ;
    rdfs:label "afluria 2015-2016 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003716, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003717
    ] .

obo:VO_0003719
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661805" ;
    obo:VO_0003198 1661805 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Afluria 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4046988", "RXAUI: 7264717", "TUI: T200" ;
    rdfs:label "Afluria 2015-2016 Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003716 .

obo:VO_0003720
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1661807" ;
    obo:VO_0003198 1661807 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/South Australia/55/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Afluria 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4018774", "RXAUI: 7264719, 7264723, 7707305", "TUI: T200" ;
    rdfs:label "Afluria 2015-2016 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003719, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003717
    ] .

obo:VO_0003721
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799399" ;
    obo:VO_0003198 1799399 ;
    a owl:Class ;
    rdfs:comment "CUI: C4224216", "RXAUI: 8234382", "TUI: T116, T129, T121" ;
    rdfs:label "Afluria 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0000006, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003722
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799402" ;
    obo:VO_0003198 1799402 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271746", "RXAUI: 8234385", "TUI: T200" ;
    rdfs:label "Afluria 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003721 .

obo:VO_0003723
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799400" ;
    obo:VO_0003198 1799400 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271652", "RXAUI: 8234383", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML [Afluria 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003721, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ] .

obo:VO_0003724
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799413" ;
    obo:VO_0003198 1799413 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Injectable Suspension [Afluria 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224196", "RXAUI: 8234404, 8234405, 8234406", "TUI: T200" ;
    rdfs:label "Afluria 2016-2017 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003722, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003723
    ] .

obo:VO_0003725
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799401" ;
    obo:VO_0003198 1799401 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Afluria 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271691", "RXAUI: 8234384", "TUI: T200" ;
    rdfs:label "Afluria 2016-2017 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003722 .

obo:VO_0003726
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799403" ;
    obo:VO_0003198 1799403 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Prefilled Syringe [Afluria 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224214", "RXAUI: 8236926, 8234386, 8236927", "TUI: T200" ;
    rdfs:label "afluria 2016-2017 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003725, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003723
    ] .

obo:VO_0003727
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942128" ;
    obo:VO_0003198 1942128 ;
    a owl:Class ;
    rdfs:comment "CUI: C4325193", "RXAUI: 9267473", "TUI: T129, T121" ;
    rdfs:label "Afluria 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0000006, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003728
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942131" ;
    obo:VO_0003198 1942131 ;
    a owl:Class ;
    rdfs:comment "CUI: C4519949", "RXAUI: 9267476", "TUI: T200" ;
    rdfs:label "Afluria 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003727 .

obo:VO_0003729
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942129" ;
    obo:VO_0003198 1942129 ;
    a owl:Class ;
    rdfs:comment "CUI: C4519947", "RXAUI: 9267474", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/46/2015 antigen 0.03 MG/ML [Afluria 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003727, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003730
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942158" ;
    obo:VO_0003198 1942158 ;
    obo:VO_0003560 "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/46/2015 antigen 0.03 MG/ML Injectable Suspension [Afluria 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325058", "RXAUI: 9267492, 9267490, 9267491", "TUI: T200" ;
    rdfs:label "Afluria 2017-2018 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003728 .

obo:VO_0003731
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942130" ;
    obo:VO_0003198 1942130 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Afluria 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4519948", "RXAUI: 1942130", "TUI: T200" ;
    rdfs:label "Afluria 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003728 .

obo:VO_0003732
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942132" ;
    obo:VO_0003198 1942132 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/46/2015 antigen 0.03 MG/ML Prefilled Syringe [Afluria 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325060", "RXAUI: 9267481, 9267480, 9267477", "TUI: T200" ;
    rdfs:label "Afluria 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003731 .

obo:VO_0003733
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050767" ;
    obo:VO_0003198 2050767 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719173", "RXAUI: 10290502", "TUI: T116, T129, T121" ;
    rdfs:label "Afluria 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0000006, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003734
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050770" ;
    obo:VO_0003198 2050770 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719176", "RXAUI: 10290505", "TUI: T200" ;
    rdfs:label "Afluria 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003733 .

obo:VO_0003735
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050768" ;
    obo:VO_0003198 2050768 ;
    obo:VO_0003560 "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML [Afluria 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719174", "RXAUI: 10290503", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML [Afluria 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003733, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003664
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003736
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050771" ;
    obo:VO_0003198 2050771 ;
    obo:VO_0003560 "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML Injectable Suspension [Afluria 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719177", "RXAUI: 10290510, 10290509, 10290506", "TUI: T200" ;
    rdfs:label "afluria 2018-2019 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003734, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003735
    ] .

obo:VO_0003737
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050802" ;
    obo:VO_0003198 2050802 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Afluria 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719203", "RXAUI: 10290573", "TUI: T200" ;
    rdfs:label "Afluria 2018-2019 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003734 .

obo:VO_0003738
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050803" ;
    obo:VO_0003198 2050803 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML Prefilled Syringe [Afluria 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719204", "RXAUI: 10292876, 10290577, 10292877", "TUI: T200" ;
    rdfs:label "Afluria 2018-2019 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003737, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003735
    ] .

obo:VO_0003739
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1858962" ;
    obo:VO_0003198 1858962 ;
    a owl:Class ;
    rdfs:comment "CUI: C4293490", "RXAUI: 8698886", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2016-2017 Formula Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003744 .

obo:VO_0003740
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1858960" ;
    obo:VO_0003198 1858960 ;
    a owl:Class ;
    rdfs:comment "CUI: C4293406", "RXAUI: 8698884", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Afluria Quadrivalent 2016-2017 Formula]"@en ;
    rdfs:subClassOf obo:VO_0003744, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ] .

obo:VO_0003741
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1858966" ;
    obo:VO_0003198 1858966 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Afluria Quadrivalent 2016-2017 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4293383", "RXAUI: 8698910, 8698890, 8698911", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2016-2017 Formula Influenza Virus Vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003739, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003740
    ] .

obo:VO_0003742
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1858961" ;
    obo:VO_0003198 1858961 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Afluria Quadrivalent 2016-2017 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4293449", "RXAUI: 8698885", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2016-2017 Formula Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003739 .

obo:VO_0003743
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1858963" ;
    obo:VO_0003198 1858963 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Afluria Quadrivalent 2016-2017 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4283663", "RXAUI: 8698892, 8698891, 8698887", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2016-2017 Formula 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003742, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003740
    ] .

obo:VO_0003744
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1858959" ;
    obo:VO_0003198 1858959 ;
    a owl:Class ;
    rdfs:comment "CUI: C4293360", "RXAUI: 8698883", "TUI: T116, T129, T121" ;
    rdfs:label "Afluria Quadrivalent 2016-2017 Formula"@en ;
    rdfs:subClassOf obo:VO_0001817, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003745
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942162" ;
    obo:VO_0003198 1942162 ;
    a owl:Class ;
    rdfs:comment "CUI: C4325196", "RXAUI: 9267495", "TUI: T129, T121" ;
    rdfs:label "Afluria Quadrivalent 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0001817, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003746
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942165" ;
    obo:VO_0003198 1942165 ;
    a owl:Class ;
    rdfs:comment "CUI: C4519959", "RXAUI: 9267498", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003745 .

obo:VO_0003747
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942163" ;
    obo:VO_0003198 1942163 ;
    a owl:Class ;
    rdfs:comment "CUI: C4519957", "RXAUI: 9267496", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/46/2015 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Afluria Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003745, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003748
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942173" ;
    obo:VO_0003198 1942173 ;
    obo:VO_0003560 "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/46/2015 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Afluria Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325066", "RXAUI: 9267520, 9267517, 9267516", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2017-2018 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003746, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003747
    ] .

obo:VO_0003749
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942164" ;
    obo:VO_0003198 1942164 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Afluria Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4519958", "RXAUI: 9267497", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003746 .

obo:VO_0003750
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1942166" ;
    obo:VO_0003198 1942166 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/46/2015 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Afluria Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325063", "RXAUI: 9272502, 9267499, 9272501", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003749, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003747
    ] .

obo:VO_0003751
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050791" ;
    obo:VO_0003198 2050791 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719195", "RXAUI: 10290555", "TUI: T116, T129, T121" ;
    rdfs:label "Afluria Quadrivalent 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0001817, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003752
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050794" ;
    obo:VO_0003198 2050794 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719198", "RXAUI: 10290558", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003751 .

obo:VO_0003753
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050792" ;
    obo:VO_0003198 2050792 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719196", "RXAUI: 10290556", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Afluria Quadrivalent 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003751, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003664
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003754
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050795" ;
    obo:VO_0003198 2050795 ;
    obo:VO_0003560 "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Afluria Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4553815", "RXAUI: 10322944, 10290561, 10290559", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2018-2019 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003752, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003753
    ] .

obo:VO_0003755
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050796" ;
    obo:VO_0003198 2050796 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Afluria Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719199", "RXAUI: 10290562", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2018-2019 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003752 .

obo:VO_0003756
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050797" ;
    obo:VO_0003198 2050797 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Afluria Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4553814", "RXAUI: 10322943, 10322942, 10290563", "TUI: T200" ;
    rdfs:label "Afluria Quadrivalent 2018-2019 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003755, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003753
    ] .

obo:VO_0003757
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799102" ;
    obo:VO_0003198 1799102 ;
    a owl:Class ;
    rdfs:comment "CUI: C4224220", "RXAUI: 8233849", "TUI: T116, T129, T121" ;
    rdfs:label "Flulaval Quadrivalent 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0003071, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003758
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799105" ;
    obo:VO_0003198 1799105 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271755", "RXAUI: 8233852", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003757 .

obo:VO_0003759
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799103" ;
    obo:VO_0003198 1799103 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Flulaval Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271659", "RXAUI: 8233850", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Flulaval Quadrivalent 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003757, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ] .

obo:VO_0003760
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799205" ;
    obo:VO_0003198 1799205 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Flulaval Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224211", "RXAUI: 1799205", "TUI: T200" ;
    rdfs:label "FLULAVAL QUADRIVALENT 2016-2017 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003758, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003759
    ] .

obo:VO_0003761
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799104" ;
    obo:VO_0003198 1799104 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flulaval Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271700", "RXAUI: 8233851", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2016-2017 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003758 .

obo:VO_0003762
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799106" ;
    obo:VO_0003198 1799106 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Flulaval Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4255281", "RXAUI: 8233853, 8233905, 8233906", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2016-2017 vaccine 0.5 Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003761, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003759
    ] .

obo:VO_0003763
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657335" ;
    obo:VO_0003198 1657335 ;
    a owl:Class ;
    rdfs:comment "CUI: C4026650", "RXAUI: 7251229", "TUI: T116, T129, T121" ;
    rdfs:label "FluLaval Quadrivalent 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0003071, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ] .

obo:VO_0003764
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657338" ;
    obo:VO_0003198 1657338 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033911", "RXAUI: 7251232", "TUI: T200" ;
    rdfs:label "FluLaval Quadrivalent 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003763 .

obo:VO_0003765
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657336" ;
    obo:VO_0003198 1657336 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [FluLaval Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033750", "RXAUI: 7251230", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [FluLaval Quadrivalent 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003763, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003472
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ] .

obo:VO_0003766
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657339" ;
    obo:VO_0003198 1657339 ;
    obo:VO_0003560 "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [FluLaval Quadrivalent 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4018811", "RXAUI: 7251233, 7707287", "TUI: T200" ;
    rdfs:label "FLULAVAL QUADRIVALENT 2015-2016 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003764, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003765
    ] .

obo:VO_0003767
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928325" ;
    obo:VO_0003198 1928325 ;
    a owl:Class ;
    rdfs:comment "CUI: C4325209", "RXAUI: 9198793", "TUI: T116, T129, T121" ;
    rdfs:label "Flulaval Quadrivalent 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0003071, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003768
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928328" ;
    obo:VO_0003198 1928328 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490418", "RXAUI: 9198796", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003767 .

obo:VO_0003769
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928326" ;
    obo:VO_0003198 1928326 ;
    obo:VO_0003560 "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Flulaval Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490416", "RXAUI: 9198794", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Flulaval Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003767, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003770
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928329" ;
    obo:VO_0003198 1928329 ;
    obo:VO_0003560 "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Flulaval Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4319520", "RXAUI: 9198867, 9198866, 9198797", "TUI: T200" ;
    rdfs:label "FLULAVAL QUADRIVALENT 2017-2018 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003768, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003769
    ] .

obo:VO_0003771
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928335" ;
    obo:VO_0003198 1928335 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flulaval Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490423", "RXAUI: 9198815", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003768 .

obo:VO_0003772
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928336" ;
    obo:VO_0003198 1928336 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Flulaval Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4319519", "RXAUI: 9198862, 9198816, 9198863", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003771, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003769
    ] .

obo:VO_0003773
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048970" ;
    obo:VO_0003198 2048970 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704197", "RXAUI: 10279949", "TUI: T116, T129, T121" ;
    rdfs:label "Flulaval Quadrivalent 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0003071, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003774
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048973" ;
    obo:VO_0003198 2048973 ;
    a owl:Class ;
    rdfs:comment "CUI: C4704200", "RXAUI: 10279952", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003773 .

obo:VO_0003775
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048971" ;
    obo:VO_0003198 2048971 ;
    obo:VO_0003560 "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Flulaval Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4704198", "RXAUI: 10279950", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML [Flulaval Quadrivalent 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003773, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003489
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003664
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003776
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:VO_0003198 2048974 ;
    obo:VO_0003560 "http://purl.bioontology.org/ontology/RXNORM/2048974", "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Injectable Suspension [Flulaval Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4552692", "RXAUI: 10279953, 10279956, 10279954", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2018-2019 vaccine Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003774, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003775
    ] .

obo:VO_0003777
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048975" ;
    obo:VO_0003198 2048975 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flulaval Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4704201", "RXAUI: 10279957", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2018-2019 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003774 .

obo:VO_0003778
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2048976" ;
    obo:VO_0003198 2048976 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.03 MG/ML Prefilled Syringe [Flulaval Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4552691", "RXAUI: 10279960, 10279959, 10279958", "TUI: T200" ;
    rdfs:label "Flulaval Quadrivalent 2018-2019 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003777, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003775
    ] .

obo:VO_0003779
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657140" ;
    obo:VO_0003198 1657140 ;
    a owl:Class ;
    rdfs:comment "CUI: C4026649", "RXAUI: 7251081", "TUI: T116, T129, T121" ;
    rdfs:label "Flucelvax 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0000980, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003475
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003477
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003486
    ] .

obo:VO_0003780
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657143" ;
    obo:VO_0003198 1657143 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033914", "RXAUI: 7251084", "TUI: T200" ;
    rdfs:label "Flucelvax 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003779 .

obo:VO_0003781
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657141" ;
    obo:VO_0003198 1657141 ;
    obo:VO_0003560 "influenza A virus A/Brisbane/10/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/South Australia/55/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML [Flucelvax 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033757", "RXAUI: 7251082", "TUI: T200" ;
    rdfs:label "influenza A virus A/Brisbane/10/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/South Australia/55/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML [Flucelvax 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003779, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003476
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003478
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003487
    ] .

obo:VO_0003782
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657142" ;
    obo:VO_0003198 1657142 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flucelvax 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033857", "RXAUI: 7251083", "TUI: T200" ;
    rdfs:label "FLUCELVAX 2015-2016 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003780 .

obo:VO_0003783
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657144" ;
    obo:VO_0003198 1657144 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Brisbane/10/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/South Australia/55/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML Prefilled Syringe [Flucelvax 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4026363", "RXAUI: 7251085, 8725354, 7707232", "TUI: T200" ;
    rdfs:label "FLUCELVAX 2015-2016 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003782, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003781
    ] .

obo:VO_0003784
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801607" ;
    obo:VO_0003198 1801607 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276115", "RXAUI: 8238453", "TUI: T129, T121" ;
    rdfs:label "Flucelvax Quadrivalent 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0003070, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003477
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003486
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003789
    ] .

obo:VO_0003785
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801610" ;
    obo:VO_0003198 1801610 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276265", "RXAUI: 8238456", "TUI: T200" ;
    rdfs:label "Flucelvax Quadrivalent 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003784 .

obo:VO_0003786
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801608" ;
    obo:VO_0003198 1801608 ;
    obo:VO_0003560 "influenza A virus A/Brisbane/10/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Hong Kong/259/2010 antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML [Flucelvax Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4276184", "RXAUI: 8238454", "TUI: T200" ;
    rdfs:label "influenza A virus A/Brisbane/10/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Hong Kong/259/2010 antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML [Flucelvax Quadrivalent 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003784, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003478
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003487
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003790
    ] .

obo:VO_0003787
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801609" ;
    obo:VO_0003198 1801609 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flucelvax Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4276248", "RXAUI: 8238455", "TUI: T200" ;
    rdfs:label "FLUCELVAX QUADRIVALENT 2016-2017 Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003785 .

obo:VO_0003788
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:VO_0003198 1801611 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Brisbane/10/2010 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Hong Kong/259/2010 antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML Prefilled Syringe [Flucelvax Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4256265", "RXAUI: 8238461, 8238460, 8238457", "TUI: T200" ;
    rdfs:label "FLUCELVAX QUADRIVALENT 2016-2017 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003787, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003786
    ] .

obo:VO_0003789
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801603" ;
    obo:VO_0003198 1801603 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276030", "RXAUI: 8238449", "TUI: T116, T129, T121" ;
    rdfs:label "influenza B virus B/Hong Kong/259/2010 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003784
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003791
    ] .

obo:VO_0003790
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801604" ;
    obo:VO_0003198 1801604 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276333", "RXAUI: 8238450", "TUI: T200" ;
    rdfs:label "influenza B virus B/Hong Kong/259/2010 antigen 0.03 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003789 .

obo:VO_0003791
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928533" ;
    obo:VO_0003198 1928533 ;
    a owl:Class ;
    rdfs:comment "CUI: C4325207", "RXAUI: 9199341", "TUI: T116, T129, T121" ;
    rdfs:label "Flucelvax Quadrivalent 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0003070, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003486
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003789
    ] .

obo:VO_0003792
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928536" ;
    obo:VO_0003198 1928536 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490504", "RXAUI: 9199344", "TUI: T200" ;
    rdfs:label "Flucelvax Quadrivalent 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003791 .

obo:VO_0003793
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928534" ;
    obo:VO_0003198 1928534 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490502", "RXAUI: 9199342", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP2050/2015 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Hong Kong/259/2010 antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML [Flucelvax Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003791, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003487
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003790
    ] .

obo:VO_0003794
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928537" ;
    obo:VO_0003198 1928537 ;
    obo:VO_0003560 "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP2050/2015 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Hong Kong/259/2010 antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML Injectable Suspension [Flucelvax Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490505", "RXAUI: 9199345, 9199362, 9199359", "TUI: T200" ;
    rdfs:label "FLUCELVAX Quadrivalent 2017-2018 Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0003792, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003793
    ] .

obo:VO_0003795
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928539" ;
    obo:VO_0003198 1928539 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flucelvax Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490507", "RXAUI: 9199347", "TUI: T200" ;
    rdfs:label "Flucelvax Quadrivalent 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003792 .

obo:VO_0003796
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928540" ;
    obo:VO_0003198 1928540 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP2050/2015 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Hong Kong/259/2010 antigen 0.03 MG/ML / influenza B virus B/Utah/9/2014 antigen 0.03 MG/ML Prefilled Syringe [Flucelvax Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325069", "RXAUI: 9199352, 9199361, 9199348", "TUI: T200" ;
    rdfs:label "Flucelvax Quadrivalent 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003795, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003793
    ] .

obo:VO_0003797
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1986826" ;
    obo:VO_0003198 1986826 ;
    a owl:Class ;
    rdfs:comment "CUI: C4530100", "RXAUI: 9698281", "TUI: T129, T121" ;
    rdfs:label "Shingrix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003317 .

obo:VO_0003798
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1986827" ;
    obo:VO_0003198 1986827 ;
    a owl:Class ;
    rdfs:comment "CUI: C4530101", "RXAUI: 9698282", "TUI: T200" ;
    rdfs:label "Varicella zoster virus glycoprotein E, recombinant 0.1 MG/ML [Shingrix]"@en ;
    rdfs:subClassOf obo:VO_0003317, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003803
    ] .

obo:VO_0003799
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "0.5 ML Shingrix 0.1 MG/ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1986830" ;
    obo:VO_0003198 1986830 ;
    obo:VO_0003560 "0.5 ML Varicella zoster virus glycoprotein E, recombinant 0.1 MG/ML Injection [Shingrix]" ;
    a owl:Class ;
    rdfs:comment "RXAUI: 9698706, 9698285, 9698287, 9698286", "TUI: T200" ;
    rdfs:label "Shingrix vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003797, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003798
    ] .

obo:VO_0003800
    a owl:Class ;
    rdfs:label "0.5 ML Shingrix 0.1 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003799 .

obo:VO_0003801
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1986821" ;
    obo:VO_0003198 1986821 ;
    a owl:Class ;
    rdfs:comment "CUI: C0061673", "RXAUI: 9698276", "TUI: T116, T129, T121" ;
    rdfs:label "Varicella zoster virus glycoprotein E"@en ;
    rdfs:subClassOf obo:VO_0010792 .

obo:VO_0003802
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1986820" ;
    obo:VO_0003198 1986820 ;
    a owl:Class ;
    rdfs:comment "CUI: C4530095", "RXAUI: 9698275", "TUI: T116, T129, T121" ;
    rdfs:label "Varicella zoster virus glycoprotein E, recombinant"@en ;
    rdfs:subClassOf obo:VO_0003801, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003317
    ] .

obo:VO_0003803
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1986822" ;
    obo:VO_0003198 1986822 ;
    a owl:Class ;
    rdfs:comment "CUI: C4530096", "RXAUI: 9698277", "TUI: T200" ;
    rdfs:label "Varicella zoster virus glycoprotein E, recombinant 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003802 .

obo:VO_0003804
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664639" ;
    obo:VO_0003198 1664639 ;
    a owl:Class ;
    rdfs:comment "CUI: C4026651", "RXAUI: 7266972", "TUI: T116, T129, T121" ;
    rdfs:label "influenza A virus A/Bolivia/559/2013 (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0015084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003806
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003807
    ] .

obo:VO_0003805
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664467" ;
    obo:VO_0003198 1664467 ;
    a owl:Class ;
    rdfs:comment "CUI: C4050818", "RXAUI: 7266777", "TUI: T200" ;
    rdfs:label "influenza A virus A/Bolivia/559/2013 (H1N1) antigen 50000000 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003804 .

obo:VO_0003806
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664639" ;
    obo:VO_0003198 1664639 ;
    a owl:Class ;
    rdfs:comment "CUI: C4026651", "RXAUI: 7266972", "TUI: T116, T129, T121" ;
    rdfs:label "Flumist 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0000044, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003804
    ] .

obo:VO_0003807
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801825" ;
    obo:VO_0003198 1801825 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276113", "RXAUI: 8238995", "TUI: T116, T129, T121" ;
    rdfs:label "Flumist Quadrivalent 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0000982, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003804
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003811
    ] .

obo:VO_0003808
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946970" ;
    obo:VO_0003198 1946970 ;
    a owl:Class ;
    rdfs:comment "CUI: C4529647", "RXAUI: 9278624", "TUI: T116, T129, T121" ;
    rdfs:label "Flumist Quadrivalent 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0000982, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003811
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003818
    ] .

obo:VO_0003809
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664644" ;
    obo:VO_0003198 1664644 ;
    obo:VO_0003560 "influenza A virus A/Bolivia/559/2013 (H1N1) antigen 50000000 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 50000000 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 50000000 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 50000000 MG/ML Nasal Spray [Flumist 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4026361", "RXAUI: 7266797, 7266977, 7266796", "TUI: T200" ;
    rdfs:label "FluMist Quadrivalent, 2015-2016 Formula Nasal Spray"@en ;
    rdfs:subClassOf obo:VO_0003806, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003810
    ] .

obo:VO_0003810
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1664640" ;
    obo:VO_0003198 1664640 ;
    a owl:Class ;
    rdfs:comment "CUI: C4050879", "RXAUI: 7266973", "TUI: T200" ;
    rdfs:label "influenza A virus A/Bolivia/559/2013 (H1N1) antigen 50000000 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 50000000 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 50000000 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 50000000 MG/ML [Flumist 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0000044, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003474
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003481
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003493
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003805
    ] .

obo:VO_0003811
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801767" ;
    obo:VO_0003198 1801767 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276025", "RXAUI: 8238906", "TUI: T116, T129, T121" ;
    rdfs:label "influenza A virus A/New Caledonia/71/2014 (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003807
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003808
    ] .

obo:VO_0003812
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801822" ;
    obo:VO_0003198 1801822 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276331", "RXAUI: 8238992", "TUI: T200" ;
    rdfs:label "influenza A virus A/New Caledonia/71/2014 (H3N2) antigen 50000000 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003811 .

obo:VO_0003813
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801826" ;
    obo:VO_0003198 1801826 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276182", "RXAUI: 8238996", "TUI: T200" ;
    rdfs:label "influenza A virus A/Bolivia/559/2013 (H1N1) antigen 50000000 MG/ML / influenza A virus A/New Caledonia/71/2014 (H3N2) antigen 50000000 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 50000000 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 50000000 MG/ML [Flumist Quadrivalent 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0000982, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003481
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003493
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003805
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003812
    ] .

obo:VO_0003814
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "FluMist Quadrivalent, Live Attenuated, 2016-2017 Formula Nasal Spray" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801830" ;
    obo:VO_0003198 1801830 ;
    obo:VO_0003560 "influenza A virus A/Bolivia/559/2013 (H1N1) antigen 50000000 MG/ML / influenza A virus A/New Caledonia/71/2014 (H3N2) antigen 50000000 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 50000000 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 50000000 MG/ML Nasal Spray [Flumist Quadrivalent 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224207", "RXAUI: 8239001, 8239002, 8239000", "TUI: T200" ;
    rdfs:label "FluMist Quadrivalent, 2016-2017 Formula Nasal Spray"@en ;
    rdfs:subClassOf obo:VO_0003807, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003813
    ] .

obo:VO_0003815
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946985" ;
    obo:VO_0003198 1946985 ;
    a owl:Class ;
    rdfs:comment "CUI: C4529659", "RXAUI: 9278648", "TUI: T200" ;
    rdfs:label "influenza A virus A/New Caledonia/71/2014 (H3N2) antigen 158000000 UNT/ML / influenza A virus A/Slovenia/2903/2015 (H1N1) antigen 158000000 UNT/ML / influenza B virus B/Brisbane/60/2008 antigen 158000000 UNT/ML / influenza B virus B/Phuket/3073/2013 antigen 158000000 UNT/ML [Flumist Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003808, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003485
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003492
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003817
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003819
    ] .

obo:VO_0003816
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "FluMist Quadrivalent, Live Attenuated, 2017-2018 Formula Nasal Spray" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946986" ;
    obo:VO_0003198 1946986 ;
    obo:VO_0003560 "influenza A virus A/New Caledonia/71/2014 (H3N2) antigen 158000000 UNT/ML / influenza A virus A/Slovenia/2903/2015 (H1N1) antigen 158000000 UNT/ML / influenza B virus B/Brisbane/60/2008 antigen 158000000 UNT/ML / influenza B virus B/Phuket/3073/2013 antigen 158000000 UNT/ML Nasal Spray [Flumist Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4522486", "RXAUI: 9278652, 9278649, 9278653", "TUI: T200" ;
    rdfs:label "FluMist Quadrivalent, 2017-2018 Formula Nasal Spray"@en ;
    rdfs:subClassOf obo:VO_0003808, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003815
    ] .

obo:VO_0003817
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946980" ;
    obo:VO_0003198 1946980 ;
    a owl:Class ;
    rdfs:comment "CUI: C4529654", "RXAUI: 9278643", "TUI: T200" ;
    rdfs:label "influenza A virus A/New Caledonia/71/2014 (H3N2) antigen 158000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003811 .

obo:VO_0003818
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946964" ;
    obo:VO_0003198 1946964 ;
    a owl:Class ;
    rdfs:comment "CUI: C4522494", "RXAUI: 9278618", "TUI: T116, T129, T121" ;
    rdfs:label "influenza A virus A/Slovenia/2903/2015 (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0015084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003808
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003820
    ] .

obo:VO_0003819
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1946981" ;
    obo:VO_0003198 1946981 ;
    a owl:Class ;
    rdfs:comment "CUI: C4529655", "RXAUI: 9278644", "TUI: T200" ;
    rdfs:label "influenza A virus A/Slovenia/2903/2015 (H1N1) antigen 158000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003818 .

obo:VO_0003820
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2054182" ;
    obo:VO_0003198 2054182 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719703", "RXAUI: 10329701", "TUI: T116, T129, T121" ;
    rdfs:label "Flumist Quadrivalent 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0000982, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003818
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003821
    ] .

obo:VO_0003821
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2054177" ;
    obo:VO_0003198 2054177 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719701", "RXAUI: 10329696", "TUI: T116, T129, T121" ;
    rdfs:label "influenza B virus B/Colorado/06/2017 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003820
    ] .

obo:VO_0003822
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2054271" ;
    obo:VO_0003198 2054271 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719748", "RXAUI: 10329902", "TUI: T200" ;
    rdfs:label "influenza B virus B/Colorado/06/2017 antigen 158000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003821 .

obo:VO_0003823
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2054273" ;
    obo:VO_0003198 2054273 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719750", "RXAUI: 10329904", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 158000000 UNT/ML / influenza A virus A/Slovenia/2903/2015 (H1N1) antigen 158000000 UNT/ML / influenza B virus B/Colorado/06/2017 antigen 158000000 UNT/ML / influenza B virus B/Phuket/3073/2013 antigen 158000000 UNT/ML [Flumist Quadrivalent 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003820, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003492
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003819
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003822
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003825
    ] .

obo:VO_0003824
    obo:IAO_0000118 "FluMist Quadrivalent, Live Attenuated, 2018-2019 Formula Nasal Spray" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2054274" ;
    obo:VO_0003198 2054274 ;
    obo:VO_0003560 "influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 158000000 UNT/ML / influenza A virus A/Slovenia/2903/2015 (H1N1) antigen 158000000 UNT/ML / influenza B virus B/Colorado/06/2017 antigen 158000000 UNT/ML / influenza B virus B/Phuket/3073/2013 antigen 158000000 UNT/ML Nasal Spray [Flumist Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719751", "RXAUI: 10329907, 10329905, 10329906", "TUI: T200" ;
    rdfs:label "FluMist Quadrivalent, 2018-2019 Formula Nasal Spray"@en ;
    rdfs:subClassOf obo:VO_0003820, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003823
    ] .

obo:VO_0003825
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2054270" ;
    obo:VO_0003198 2054270 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719747", "RXAUI: 10329901", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 158000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003601 .

obo:VO_0003826
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1166526" ;
    obo:VO_0003198 1166526 ;
    a owl:Class ;
    rdfs:comment "CUI: C3220746", "RXAUI: 3837627", "TUI: T200" ;
    rdfs:label "Havrix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000052 .

obo:VO_0003827
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798365" ;
    obo:VO_0003198 798365 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344345", "RXAUI: 2851478", "TUI: T200" ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML [Havrix]"@en ;
    rdfs:subClassOf obo:VO_0003826, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003431
    ] .

obo:VO_0003828
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "0.5 ML Havrix 1440 UNT/ML Injection", "Havrix 720 UNT per 0.5 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658066" ;
    obo:VO_0003198 1658066 ;
    obo:VO_0003560 "0.5 ML Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML Injection [Havrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3888157", "RXAUI: 7252248, 7252247, 7253517, 7252251", "TUI: T200" ;
    rdfs:label "HAVRIX pediatric/adolescent vaccine 720 UNT in 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003830, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003827
    ] .

obo:VO_0003829
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "1 ML Havrix 1440 UNT/ML Injection", "Havrix 1440 UNT per 1 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658060" ;
    obo:VO_0003198 1658060 ;
    obo:VO_0003560 "1 ML Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML Injection [Havrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1637805", "RXAUI: 7252240, 7253646, 7252252, 7252239", "TUI: T200" ;
    rdfs:label "HAVRIX adult vaccine 1440 UNT in 1 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003830, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003827
    ] .

obo:VO_0003830
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658059" ;
    obo:VO_0003198 1658059 ;
    obo:VO_0003560 "Hepatitis A Vaccine (Inactivated) Strain HM175 Injection [Havrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033811", "RXAUI: 7252238", "TUI: T200" ;
    rdfs:label "HAVRIX Injection"@en ;
    rdfs:subClassOf obo:VO_0003826 .

obo:VO_0003831
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "HAVRIX pediatric/adolescent vaccine 720 UNT in 0.5 ML Prefilled Syringe", "Havrix 720 UNT per 0.5 ML Prefilled Syringe, 0.5 ML" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798482" ;
    obo:VO_0003198 798482 ;
    obo:VO_0003560 "0.5 ML Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML Prefilled Syringe [Havrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2344406", "RXAUI: 3271879, 7253645, 3066070, 2851611", "TUI: T200" ;
    rdfs:label "Havrix, Hepatitis A Vaccine (Inactivated), (Pediatric Dose) 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003833, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003827
    ] .

obo:VO_0003832
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "1 ML Hepatitis A Vaccine (Inactivated) Strain HM175 1440 UNT/ML Prefilled Syringe [Havrix]", "HAVRIX adult vaccine 1440 UNT in 1 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798479" ;
    obo:VO_0003198 798479 ;
    a owl:Class ;
    rdfs:comment "CUI: C1322283", "RXAUI: 2851606, 7239762, 7253516", "TUI: T200" ;
    rdfs:label "Havrix, Hepatitis A Vaccine (Inactivated), (Adult Dose) 1 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003833, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003827
    ] .

obo:VO_0003833
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798478" ;
    obo:VO_0003198 798478 ;
    obo:VO_0003560 "Hepatitis A Vaccine (Inactivated) Strain HM175 Prefilled Syringe [Havrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2344405", "RXAUI: 2851605", "TUI: T200" ;
    rdfs:label "Havrix Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003826 .

obo:VO_0003834
    a owl:Class ;
    rdfs:label "poliovirus vaccine inactivated"@en ;
    rdfs:subClassOf obo:VO_0000664 .

obo:VO_0003835
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763096" ;
    obo:VO_0003198 763096 ;
    a owl:Class ;
    rdfs:comment "CUI: C2242156", "RXAUI: 5026693", "TUI: T129, T121" ;
    rdfs:label "poliovirus vaccine inactivated, type 1 (Mahoney)"@en ;
    rdfs:subClassOf obo:VO_0003834, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000054
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000084
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003836
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763098" ;
    obo:VO_0003198 763098 ;
    a owl:Class ;
    rdfs:comment "CUI: C2242158", "RXAUI: 5026694", "TUI: T129, T121" ;
    rdfs:label "poliovirus vaccine inactivated, type 2 (MEF-1)"@en ;
    rdfs:subClassOf obo:VO_0003834, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000054
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000084
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003837
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763100" ;
    obo:VO_0003198 763100 ;
    a owl:Class ;
    rdfs:comment "CUI: C2242160", "RXAUI: 5026695", "TUI: T129, T121" ;
    rdfs:label "poliovirus vaccine inactivated, type 3 (Saukett)"@en ;
    rdfs:subClassOf obo:VO_0003834, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000054
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000067
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000082
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000084
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010736
    ] .

obo:VO_0003838
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1178815" ;
    obo:VO_0003198 1178815 ;
    a owl:Class ;
    rdfs:comment "CUI: C3232713", "RXAUI: 3842767", "TUI: T200" ;
    rdfs:label "PEDIARIX Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000082 .

obo:VO_0003839
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/829972" ;
    obo:VO_0003198 829972 ;
    a owl:Class ;
    rdfs:comment "CUI: C2586685", "RXAUI: 5027365", "TUI: T200" ;
    rdfs:label "acellular pertussis vaccine, inactivated 0.116 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / Hepatitis B Surface Antigen Vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML [PEDIARIX]"@en ;
    rdfs:subClassOf obo:VO_0003838, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003256
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003391
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003401
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003456
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003843
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003844
    ] .

obo:VO_0003840
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/829988" ;
    obo:VO_0003198 829988 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / Hepatitis B Surface Antigen Vaccine / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Prefilled Syringe [PEDIARIX]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2586690", "RXAUI: 5027414", "TUI: T200" ;
    rdfs:label "PEDIARIX vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003838 .

obo:VO_0003841
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/829989" ;
    obo:VO_0003198 829989 ;
    obo:VO_0003560 "0.5 ML acellular pertussis vaccine, inactivated 0.116 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / Hepatitis B Surface Antigen Vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Prefilled Syringe [PEDIARIX]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2586691", "RXAUI: 3634543, 7253748, 5027677", "TUI: T200" ;
    rdfs:label "PEDIARIX vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003840, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003839
    ] .

obo:VO_0003842
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763097" ;
    obo:VO_0003198 763097 ;
    a owl:Class ;
    rdfs:comment "CUI: C2242157", "RXAUI: 5027171", "TUI: T200" ;
    rdfs:label "poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003835 .

obo:VO_0003843
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763099" ;
    obo:VO_0003198 763099 ;
    a owl:Class ;
    rdfs:comment "CUI: C2242159", "RXAUI: 5027167", "TUI: T200" ;
    rdfs:label "poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003836 .

obo:VO_0003844
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763101" ;
    obo:VO_0003198 763101 ;
    a owl:Class ;
    rdfs:comment "CUI: C2242161", "RXAUI: 5027168", "TUI: T200" ;
    rdfs:label "poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003837 .

obo:VO_0003845
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300806" ;
    obo:VO_0003198 1300806 ;
    a owl:Class ;
    rdfs:comment "CUI: C2719943", "RXAUI: 4626294", "TUI: T116, T129, T121" ;
    rdfs:label "Haemophilus influenzae type b strain 20752, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0015014 .

obo:VO_0003846
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1176753" ;
    obo:VO_0003198 1176753 ;
    a owl:Class ;
    rdfs:comment "CUI: C3230691", "RXAUI: 3838525", "TUI: T200" ;
    rdfs:label "Ipol Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000054 .

obo:VO_0003847
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763104" ;
    obo:VO_0003198 763104 ;
    a owl:Class ;
    rdfs:comment "CUI: C2242163", "RXAUI: 5027360", "TUI: T200" ;
    rdfs:label "poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML [Ipol]"@en ;
    rdfs:subClassOf obo:VO_0000054, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003843
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003844
    ] .

obo:VO_0003848
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/763106" ;
    obo:VO_0003198 763106 ;
    obo:VO_0003560 "poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML Injectable Solution [Ipol]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1877934", "RXAUI: 5027670, 6816444, 7253746", "TUI: T200" ;
    rdfs:label "IPOL vaccine Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003846, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003847
    ] .

obo:VO_0003849
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/807219" ;
    obo:VO_0003198 807219 ;
    a owl:Class ;
    rdfs:comment "CUI: C0078221", "RXAUI: 2863812", "TUI: T116, T129, T121" ;
    rdfs:label "Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain"@en ;
    rdfs:subClassOf obo:VO_0003443, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000104
    ] .

obo:VO_0003850
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1187511" ;
    obo:VO_0003198 1187511 ;
    a owl:Class ;
    rdfs:comment "CUI: C3241253", "RXAUI: 3848865", "TUI: T200" ;
    rdfs:label "Typhim VI Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000104 .

obo:VO_0003851
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/807223" ;
    obo:VO_0003198 807223 ;
    a owl:Class ;
    rdfs:comment "CUI: C2365227", "RXAUI: 2863816", "TUI: T200" ;
    rdfs:label "Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain 0.05 MG/ML [Typhim VI]"@en ;
    rdfs:subClassOf obo:VO_0000104, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003855
    ] .

obo:VO_0003852
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/807225" ;
    obo:VO_0003198 807225 ;
    obo:VO_0003560 "Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain 0.05 MG/ML Injectable Solution [Typhim VI]" ;
    a owl:Class ;
    rdfs:comment "CUI: C0711001", "RXAUI: 7251850, 2863819, 2863818", "TUI: T200" ;
    rdfs:label "Typhim Vi Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003850, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003851
    ] .

obo:VO_0003853
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1486495" ;
    obo:VO_0003198 1486495 ;
    obo:VO_0003560 "Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain Prefilled Syringe [Typhim VI]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3701103", "RXAUI: 5937066", "TUI: T200" ;
    rdfs:label "Typhim VI Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003850 .

obo:VO_0003854
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "0.5 ML Typhim VI 0.05 MG/ML Prefilled Syringe", "Typhim VI 25 MCG per 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1486496" ;
    obo:VO_0003198 1486496 ;
    obo:VO_0003560 "0.5 ML Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain 0.05 MG/ML Prefilled Syringe [Typhim VI]" ;
    a owl:Class ;
    rdfs:comment "CUI: C0980908", "RXAUI: 7252822, 5937069, 5937068, 5937067", "TUI: T200" ;
    rdfs:label "Typhim Vi 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003853, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003851
    ] .

obo:VO_0003855
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/807220" ;
    obo:VO_0003198 807220 ;
    a owl:Class ;
    rdfs:comment "CUI: C2365225", "RXAUI: 2863813", "TUI: T200" ;
    rdfs:label "Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain 0.05 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003849 .

obo:VO_0003856
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1361664" ;
    obo:VO_0003198 1361664 ;
    a owl:Class ;
    rdfs:comment "CUI: C3528060", "RXAUI: 5037103", "TUI: T200" ;
    rdfs:label "Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain 0.025 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003849 .

obo:VO_0003857
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830464" ;
    obo:VO_0003198 830464 ;
    a owl:Class ;
    rdfs:comment "CUI: C2586803", "RXAUI: 5026921", "TUI: T129, T121" ;
    rdfs:label "rabies virus vaccine wistar strain PM-1503-3M (Human), Inactivated"@en ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000063
    ] .

obo:VO_0003858
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830465" ;
    obo:VO_0003198 830465 ;
    a owl:Class ;
    rdfs:comment "CUI: C2586804", "RXAUI: 5027213", "TUI: T200" ;
    rdfs:label "rabies virus vaccine wistar strain PM-1503-3M (Human), Inactivated 2.5 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003857 .

obo:VO_0003859
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659733" ;
    obo:VO_0003198 1659733 ;
    a owl:Class ;
    rdfs:comment "CUI: C4047087", "RXAUI: 7255368", "TUI: T200" ;
    rdfs:label "Imovax Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000063 .

obo:VO_0003860
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1659731" ;
    obo:VO_0003198 1659731 ;
    a owl:Class ;
    rdfs:comment "CUI: C4046958", "RXAUI: 7255366", "TUI: T200" ;
    rdfs:label "rabies virus vaccine wistar strain PM-1503-3M (Human), Inactivated 2.5 UNT/ML [Imovax]"@en ;
    rdfs:subClassOf obo:VO_0000063 .

obo:VO_0003861
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "IMOVAX rabies vaccine 2.5 UNT in 1 ML Injection", "Imovax Rabies, Wistar Rabies Virus Strain PM-1503-3M (Human) 2.5 UNT per 1 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830470" ;
    a owl:Class ;
    rdfs:comment "CUI: C0711018", "RXAUI: 7253451, 7250938, 7255369, 7255370", "TUI: T200" ;
    rdfs:label "1 ML Imovax 2.5 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003859 .

obo:VO_0003862
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830457" ;
    obo:VO_0003198 830457 ;
    a owl:Class ;
    rdfs:comment "CUI: C2586798", "RXAUI: 2939884", "TUI: T129, T121" ;
    rdfs:label "rabies virus vaccine flury-lep strain"@en ;
    rdfs:subClassOf obo:VO_0000650 .

obo:VO_0003863
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830458" ;
    obo:VO_0003198 830458 ;
    a owl:Class ;
    rdfs:comment "CUI: C2586799", "RXAUI: 2939885", "TUI: T200" ;
    rdfs:label "rabies virus vaccine flury-lep strain 2.5 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003862 .

obo:VO_0003864
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1177669" ;
    obo:VO_0003198 1177669 ;
    a owl:Class ;
    rdfs:comment "CUI: C3231586", "RXAUI: 3844818", "TUI: T200" ;
    rdfs:label "RabAvert Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000094 .

obo:VO_0003865
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830461" ;
    obo:VO_0003198 830461 ;
    a owl:Class ;
    rdfs:comment "CUI: C2586802", "RXAUI: 2939888", "TUI: T200" ;
    rdfs:label "rabies virus vaccine flury-lep strain 2.5 UNT/ML [RabAvert]"@en ;
    rdfs:subClassOf obo:VO_0000094, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003863
    ] .

obo:VO_0003866
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "RabAvert 2.5 UNT in 1 ML Injection", "RabAvert 2.5 UNT per 1 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830463" ;
    obo:VO_0003198 830463 ;
    obo:VO_0003560 "1 ML rabies virus vaccine flury-lep strain 2.5 UNT/ML Injection [RabAvert]" ;
    a owl:Class ;
    rdfs:comment "CUI: C0711019", "RXAUI: 7253136, 7250934, 7252193, 7252192", "TUI: T200" ;
    rdfs:label "1 ML RabAvert 2.5 UNT/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003864, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003865
    ] .

obo:VO_0003867
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1169861" ;
    obo:VO_0003198 1169861 ;
    a owl:Class ;
    rdfs:comment "CUI: C3223997", "RXAUI: 3837729", "TUI: T200" ;
    rdfs:label "Hiberix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0010715 .

obo:VO_0003868
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300809" ;
    obo:VO_0003198 1300809 ;
    a owl:Class ;
    rdfs:comment "CUI: C2719732", "RXAUI: 4626297", "TUI: T200" ;
    rdfs:label "Haemophilus influenzae type b strain 20752, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.07 MG/ML [Hiberix]"@en ;
    rdfs:subClassOf obo:VO_0010715, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003870
    ] .

obo:VO_0003869
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "0.5 ML Hiberix 0.07 MG/ML Injection", "Hiberix (Haemophilus influenzae type b strain 20,752, capsular polysaccharide (10 MCG) inactivated tetanus toxoid (25 MCG) conjugate vaccine) per 0.5 ML Injection", "Hiberix (Haemophilus influenzae type b strain 20,752, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine) 35 MCG per 0.5 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300810" ;
    obo:VO_0003198 1300810 ;
    obo:VO_0003560 "0.5 ML Haemophilus influenzae type b strain 20752, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.07 MG/ML Injection [Hiberix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2719734", "RXAUI: 7252256, 7252207, 7253591, 7252257, 7252206", "TUI: T200" ;
    rdfs:label "HIBERIX vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003867, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003868
    ] .

obo:VO_0003870
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300807" ;
    obo:VO_0003198 1300807 ;
    a owl:Class ;
    rdfs:comment "CUI: C2719728", "RXAUI: 4626295", "TUI: T200" ;
    rdfs:label "Haemophilus influenzae type b strain 20752, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.07 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003845 .

obo:VO_0003871
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1170172" ;
    obo:VO_0003198 1170172 ;
    a owl:Class ;
    rdfs:comment "CUI: C3224301", "RXAUI: 3831445", "TUI: T200" ;
    rdfs:label "COMVAX Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000028 .

obo:VO_0003872
    obo:IAO_0000118 "Comvax (Haemophilus influenzae b (Ross strain) capsular polysaccharide (7.5 MCG) Meningococcal Protein (125 MCG) Conjugate Vaccine / Hepatitis B Surface Antigen Vaccine 5 MCG) per 0.5 ML Injection", "Comvax, Haemophilus b Conjugate (Meningococcal Protein Conjugate) and Hepatitis B (Recombinant) Vaccine Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798443" ;
    obo:VO_0003198 798443 ;
    obo:VO_0003560 """Preferred Name	
0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.265 MG/ML / Hepatitis B Surface Antigen Vaccine 0.01 MG/ML Injection [COMVAX]""" ;
    a owl:Class ;
    rdfs:comment "CUI: C0714228", "RXAUI: 7251580, 7251337, 7253592, 7251338", "TUI: T200" ;
    rdfs:label "COMVAX Injection 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003871 .

obo:VO_0003873
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798441" ;
    obo:VO_0003198 798441 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344381", "RXAUI: 3020182", "TUI: T200" ;
    rdfs:label "Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.265 MG/ML / Hepatitis B Surface Antigen Vaccine 0.01 MG/ML [COMVAX]"@en ;
    rdfs:subClassOf obo:VO_0000028, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003413
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003423
    ] .

obo:VO_0003874
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1367001" ;
    obo:VO_0003198 1367001 ;
    a owl:Class ;
    rdfs:comment "CUI: C3531472", "RXAUI: 5048926", "TUI: T116, T121" ;
    rdfs:label "Flublok 2012-2013 Formula"@en ;
    rdfs:subClassOf obo:VO_0000978, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003497
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003521
    ] .

obo:VO_0003875
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1367004" ;
    obo:VO_0003198 1367004 ;
    a owl:Class ;
    rdfs:comment "CUI: C3531475", "RXAUI: 5048929", "TUI: T200" ;
    rdfs:label "Flublok 2012-2013 Formula Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003874 .

obo:VO_0003876
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:VO_0003198 1367005 ;
    obo:VO_0003560 "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Wisconsin-1-2010-like virus 0.09 MG/ML Injectable Solution [Flublok 2012-2013 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3531476", "RXAUI: 5048931, 5048930", "TUI: T200" ;
    rdfs:label "Flublok 2012-2013 Formula Influenza Virus Vaccine Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003875, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003877
    ] .

obo:VO_0003877
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1367002" ;
    obo:VO_0003198 1367002 ;
    a owl:Class ;
    rdfs:comment "CUI: C3531473", "RXAUI: 5048927", "TUI: T200" ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Wisconsin-1-2010-like virus 0.09 MG/ML [Flublok 2012-2013 Formula]"@en ;
    rdfs:subClassOf obo:VO_0003874, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003509
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003513
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003522
    ] .

obo:VO_0003878
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1442206" ;
    obo:VO_0003198 1442206 ;
    a owl:Class ;
    rdfs:comment "CUI: C3692550", "RXAUI: 5532833", "TUI: T116, T121" ;
    rdfs:label "Flublok 2013-2014 Formula"@en ;
    rdfs:subClassOf obo:VO_0000978, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003497
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003526
    ] .

obo:VO_0003879
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1442209" ;
    obo:VO_0003198 1442209 ;
    a owl:Class ;
    rdfs:comment "CUI: C3692553", "RXAUI: 5532836", "TUI: T200" ;
    rdfs:label "Flublok 2013-2014 Formula Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003878 .

obo:VO_0003880
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1442210" ;
    obo:VO_0003198 1442210 ;
    obo:VO_0003560 "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.09 MG/ML Injectable Solution [Flublok 2013-2014 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3651109", "RXAUI: 5532837, 5532838", "TUI: T200" ;
    rdfs:label "Flublok 2013-2014 Formula Influenza Virus Vaccine Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003879, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003881
    ] .

obo:VO_0003881
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1442207" ;
    obo:VO_0003198 1442207 ;
    a owl:Class ;
    rdfs:comment "CUI: C3692551", "RXAUI: 5532834", "TUI: T200" ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.09 MG/ML [Flublok 2013-2014 Formula]"@en ;
    rdfs:subClassOf obo:VO_0003878, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003509
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003513
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003528
    ] .

obo:VO_0003882
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1537517" ;
    obo:VO_0003198 1537517 ;
    a owl:Class ;
    rdfs:comment "CUI: C3817315", "RXAUI: 6338485", "TUI: T116, T121" ;
    rdfs:label "Flublok 2014-2015 Formula"@en ;
    rdfs:subClassOf obo:VO_0000978, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003497
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003526
    ] .

obo:VO_0003883
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1537520" ;
    obo:VO_0003198 1537520 ;
    a owl:Class ;
    rdfs:comment "CUI: C3819829", "RXAUI: 6338488", "TUI: T200" ;
    rdfs:label "Flublok 2014-2015 Formula Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003882 .

obo:VO_0003884
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1537521" ;
    obo:VO_0003198 1537521 ;
    obo:VO_0003560 "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.09 MG/ML Injectable Solution [Flublok 2014-2015 Formula]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3817268", "RXAUI: 6338489, 6338490", "TUI: T200" ;
    rdfs:label "Flublok 2014-2015 Formula Influenza Virus Vaccine Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0003883, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003885
    ] .

obo:VO_0003885
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1537518" ;
    obo:VO_0003198 1537518 ;
    a owl:Class ;
    rdfs:comment "CUI: C3819293", "RXAUI: 6338486", "TUI: T200" ;
    rdfs:label "Influenza A virus vaccine, A-California-7-2009 (H1N1)-like virus 0.09 MG/ML / Influenza A virus vaccine, A-Victoria-361-2011 (H3N2)-like virus 0.09 MG/ML / Influenza B virus vaccine, B-Massachusetts-2-2012-like virus 0.09 MG/ML [Flublok 2014-2015 Formula]"@en ;
    rdfs:subClassOf obo:VO_0003882, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003509
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003513
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003528
    ] .

obo:VO_0003886
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1660925" ;
    obo:VO_0003198 1660925 ;
    a owl:Class ;
    rdfs:comment "CUI: C4020135", "RXAUI: 7258098", "TUI: T129, T121" ;
    rdfs:label "Flublok 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0000978, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ] .

obo:VO_0003887
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1660928" ;
    obo:VO_0003198 1660928 ;
    a owl:Class ;
    rdfs:comment "CUI: C4047076", "RXAUI: 7258101", "TUI: T200" ;
    rdfs:label "Flublok 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003886 .

obo:VO_0003888
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1660926" ;
    obo:VO_0003198 1660926 ;
    a owl:Class ;
    rdfs:comment "CUI: C4046941", "RXAUI: 7258099", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML [Flublok 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003886, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003450
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003490
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003658
    ] .

obo:VO_0003889
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1660929" ;
    obo:VO_0003198 1660929 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML Injection [Flublok 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4019692", "RXAUI: 7258105, 7258102", "TUI: T200" ;
    rdfs:label "Flublok 2015-2016 vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003887, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003888
    ] .

obo:VO_0003890
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1803020" ;
    obo:VO_0003560 1803020 ;
    a owl:Class ;
    rdfs:comment "CUI: C4224215", "RXAUI: 8241253", "TUI:  T116, T129, T121" ;
    rdfs:label "Flublok 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0000978, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003891
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1803023" ;
    obo:VO_0003198 1803023 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276258", "RXAUI: 8241256", "TUI: T200" ;
    rdfs:label "Flublok 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003890 .

obo:VO_0003892
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1803021" ;
    obo:VO_0003198 1803021 ;
    a owl:Class ;
    rdfs:comment "CUI: C4276177", "RXAUI: 8241254", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML [Flublok 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003890, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003450
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003482
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003660
    ] .

obo:VO_0003893
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1803024" ;
    obo:VO_0003198 1803024 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML Injection [Flublok 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4224212", "RXAUI: 8241260, 8241257, 8241263", "TUI: T200" ;
    rdfs:label "Flublok 2016-2017 vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003891, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003892
    ] .

obo:VO_0003894
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928876" ;
    obo:VO_0003198 1928876 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490679", "RXAUI: 9199818", "TUI:  T116, T129, T121" ;
    rdfs:label "Flublok 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0000978, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003600
    ] .

obo:VO_0003895
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928879" ;
    obo:VO_0003198 1928879 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490682", "RXAUI: 9199821", "TUI: T200" ;
    rdfs:label "Flublok 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003894 .

obo:VO_0003896
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928877" ;
    obo:VO_0003198 1928877 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490680", "RXAUI: 9199819", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML [Flublok 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003894, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003482
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003660
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003662
    ] .

obo:VO_0003897
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928880" ;
    obo:VO_0003198 1928880 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML Injection [Flublok 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490683", "RXAUI: 9199203, 9199204, 9199822", "TUI: T200" ;
    rdfs:label "Flublok 2017-2018 vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003895, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003896
    ] .

obo:VO_0003898
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928347" ;
    obo:VO_0003198 1928347 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490433", "RXAUI: 9198836", "TUI: T116, T129, T121" ;
    rdfs:label "Flublok Quadrivalent 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0003067, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003600
    ] .

obo:VO_0003899
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928350" ;
    obo:VO_0003198 1928350 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490435", "RXAUI: 9198839", "TUI: T200" ;
    rdfs:label "Flublok Quadrivalent 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003898 .

obo:VO_0003900
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928361" ;
    obo:VO_0003198 1928361 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490441", "RXAUI: 9198889", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML [Flublok Quadrivalent 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003898, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003482
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003490
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003660
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003662
    ] .

obo:VO_0003901
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928362" ;
    obo:VO_0003198 1928362 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.09 MG/ML / influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML Prefilled Syringe [Flublok Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490442", "RXAUI: 9198860, 9198861, 9198890", "TUI: T200" ;
    rdfs:label "Flublok Quadrivalent 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003902, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003900
    ] .

obo:VO_0003902
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928349" ;
    obo:VO_0003198 1928349 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flublok Quadrivalent 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490434", "RXAUI: 9198838", "TUI: T200" ;
    rdfs:label "Flublok Quadrivalent 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003899 .

obo:VO_0003903
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050378" ;
    obo:VO_0003198 2050378 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719023", "RXAUI: 10289675", "TUI: T200" ;
    rdfs:label "Flublok Quadrivalent 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0003067, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003600
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ] .

obo:VO_0003904
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050381" ;
    obo:VO_0003198 2050381 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719026", "RXAUI: 10289678", "TUI: T200" ;
    rdfs:label "Flublok Quadrivalent 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003903 .

obo:VO_0003905
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050379" ;
    obo:VO_0003198 2050379 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719024", "RXAUI: 10289676", "TUI: T200" ;
    rdfs:label "influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML [Flublok Quadrivalent 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003903, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003490
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003662
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003908
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003909
    ] .

obo:VO_0003906
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050380" ;
    obo:VO_0003198 2050380 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Flublok Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719025", "RXAUI: 10289677", "TUI: T200" ;
    rdfs:label "Flublok Quadrivalent 2018-2019 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003904 .

obo:VO_0003907
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050382" ;
    obo:VO_0003198 2050382 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Michigan/45/2015 (H1N1) antigen 0.09 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.09 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.09 MG/ML / influenza B virus B/Phuket/3073/2013 antigen 0.09 MG/ML Prefilled Syringe [Flublok Quadrivalent 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719027", "RXAUI: 10289680, 10289679, 10289681", "TUI: T200" ;
    rdfs:label "Flublok Quadrivalent 2018-2019 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003906, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003905
    ] .

obo:VO_0003908
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050374" ;
    obo:VO_0003198 2050374 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719019", "RXAUI: 10289671", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003601 .

obo:VO_0003909
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050375" ;
    obo:VO_0003198 2050375 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719020", "RXAUI: 10289672", "TUI: T200" ;
    rdfs:label "influenza B virus B/Maryland/15/2016 antigen 0.09 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003602 .

obo:VO_0003910
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1724002" ;
    obo:VO_0003198 1724002 ;
    a owl:Class ;
    rdfs:comment "CUI: C4060062", "RXAUI: 7710863", "TUI: T116, T121" ;
    rdfs:label "FLUAD 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0004281, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003914
    ] .

obo:VO_0003911
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801078" ;
    obo:VO_0003198 1801078 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271566", "RXAUI: 8236918", "TUI: T116, T129, T121" ;
    rdfs:label "Fluad 2016-2017"@en ;
    rdfs:subClassOf obo:VO_0004281, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ] .

obo:VO_0003912
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928961" ;
    obo:VO_0003198 1928961 ;
    a owl:Class ;
    rdfs:comment "CUI: C4325205", "RXAUI: 9199981", "TUI: T116, T129, T121" ;
    rdfs:label "Fluad 2017-2018"@en ;
    rdfs:subClassOf obo:VO_0004281, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003599
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003913
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050759" ;
    obo:VO_0003198 2050759 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719165", "RXAUI: 10290487", "TUI: T116, T129, T121" ;
    rdfs:label "Fluad 2018-2019"@en ;
    rdfs:subClassOf obo:VO_0004281, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003601
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003602
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003713
    ] .

obo:VO_0003914
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1723997" ;
    obo:VO_0003198 1723997 ;
    a owl:Class ;
    rdfs:comment "CUI: C4059934", "RXAUI: 7710856", "TUI: T116, T129, T121" ;
    rdfs:label "influenza B virus B/Brisbane/9/2014 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003910
    ] .

obo:VO_0003915
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1724000" ;
    obo:VO_0003198 1724000 ;
    a owl:Class ;
    rdfs:comment "CUI: C4060367", "RXAUI: 7710861", "TUI: T200" ;
    rdfs:label "influenza B virus B/Brisbane/9/2014 antigen 0.015 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003914 .

obo:VO_0003916
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1724005" ;
    obo:VO_0003198 1724005 ;
    a owl:Class ;
    rdfs:comment "CUI: C4060278", "RXAUI: 7710866", "TUI: T200" ;
    rdfs:label "FLUAD 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003910 .

obo:VO_0003917
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1724011" ;
    obo:VO_0003198 1724011 ;
    a owl:Class ;
    rdfs:comment "CUI: C4060159", "RXAUI: 7710874", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.015 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.015 MG/ML / influenza B virus B/Brisbane/9/2014 antigen 0.015 MG/ML [FLUAD 2015-2016]"@en ;
    rdfs:subClassOf obo:VO_0003910, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003452
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003473
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003915
    ] .

obo:VO_0003918
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1724004" ;
    obo:VO_0003198 1724004 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [FLUAD 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4060234", "RXAUI: 7710865", "TUI: T200" ;
    rdfs:label "FLUAD 2015-2016 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003916 .

obo:VO_0003919
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "FLUAD 2015-2016 Formula Influenza Virus Vaccine 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1724012" ;
    obo:VO_0003198 1724012 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.015 MG/ML / influenza A virus A/Switzerland/9715293/2013 (H3N2) antigen 0.015 MG/ML / influenza B virus B/Brisbane/9/2014 antigen 0.015 MG/ML Prefilled Syringe [FLUAD 2015-2016]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4059806", "RXAUI: 7710870, 7710875, 7716409", "TUI: T200" ;
    rdfs:label "FLUAD 2015-2016 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003918, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003917
    ] .

obo:VO_0003920
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801081" ;
    obo:VO_0003198 1801081 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271737", "RXAUI: 8236921", "TUI: T200" ;
    rdfs:label "Fluad 2016-2017 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003911 .

obo:VO_0003921
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801079" ;
    obo:VO_0003198 1801079 ;
    a owl:Class ;
    rdfs:comment "C4271636", "RXAUI: 8236919", "TUI: T200" ;
    rdfs:label "influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML [Fluad 2016-2017]"@en ;
    rdfs:subClassOf obo:VO_0003911, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003235
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ] .

obo:VO_0003922
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801080" ;
    obo:VO_0003198 1801080 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluad 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271677", "RXAUI: 8236920", "TUI: T200" ;
    rdfs:label "Fluad 2016-2017 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003920 .

obo:VO_0003923
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1801082" ;
    obo:VO_0003198 1801082 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/California/7/2009 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Prefilled Syringe [Fluad 2016-2017]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4270828", "RXAUI: 8236922, 8236925, 8236924", "TUI: T200" ;
    rdfs:label "Fluad 2016-2017 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003922, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003921
    ] .

obo:VO_0003924
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928964" ;
    obo:VO_0003198 1928964 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490740", "RXAUI: 9199984", "TUI: T200" ;
    rdfs:label "Fluad 2017-2018 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003912 .

obo:VO_0003925
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928962" ;
    obo:VO_0003198 1928962 ;
    a owl:Class ;
    rdfs:comment "CUI: C4490738", "RXAUI: 9199982", "TUI: T200" ;
    rdfs:label "influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML [Fluad 2017-2018]"@en ;
    rdfs:subClassOf obo:VO_0003912, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003480
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003659
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003926
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928963" ;
    obo:VO_0003198 1928963 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluad 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4490739", "RXAUI: 9199983", "TUI: T200" ;
    rdfs:label "Fluad 2017-2018 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003924 .

obo:VO_0003927
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1928965" ;
    obo:VO_0003198 1928965 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Hong Kong/4801/2014 (H3N2) antigen 0.03 MG/ML / influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza B virus B/Brisbane/60/2008 antigen 0.03 MG/ML Prefilled Syringe [Fluad 2017-2018]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4325070", "RXAUI: 9199987, 9199985, 9199986", "TUI: T200" ;
    rdfs:label "Fluad 2017-2018 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003926, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003925
    ] .

obo:VO_0003928
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050762" ;
    obo:VO_0003198 2050762 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719168", "RXAUI: 10290491", "TUI: T200" ;
    rdfs:label "Fluad 2018-2019 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003913 .

obo:VO_0003929
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050760" ;
    obo:VO_0003198 2050760 ;
    a owl:Class ;
    rdfs:comment "CUI: C4719166", "RXAUI: 10290488", "TUI: T200" ;
    rdfs:label "influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML [Fluad 2018-2019]"@en ;
    rdfs:subClassOf obo:VO_0003913, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003663
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003664
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003714
    ] .

obo:VO_0003930
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050761" ;
    obo:VO_0003198 2050761 ;
    obo:VO_0003560 "influenza A virus (H1N1) antigen / influenza A virus (H3N2) antigen / influenza B virus antigen Prefilled Syringe [Fluad 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719167", "RXAUI: 10290490", "TUI: T200" ;
    rdfs:label "Fluad 2018-2019 vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003928 .

obo:VO_0003931
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050763" ;
    obo:VO_0003198 2050763 ;
    obo:VO_0003560 "0.5 ML influenza A virus A/Singapore/GP1908/2015 (H1N1) antigen 0.03 MG/ML / influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) antigen 0.03 MG/ML / influenza B virus B/Maryland/15/2016 antigen 0.03 MG/ML Prefilled Syringe [Fluad 2018-2019]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4719169", "RXAUI: 10290492, 10290493, 10290494", "TUI: T200" ;
    rdfs:label "Fluad 2018-2019 vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003930, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003929
    ] .

obo:VO_0003932
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1176026" ;
    obo:VO_0003198 1176026 ;
    a owl:Class ;
    rdfs:comment "CUI: C3229980", "RXAUI: 3836903", "TUI: T200" ;
    rdfs:label "Gardasil Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000049 .

obo:VO_0003933
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798272" ;
    obo:VO_0003198 798272 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344300", "RXAUI: 2851350", "TUI: T200" ;
    rdfs:label "L1 protein, Human papillomavirus type 11 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 16 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 18 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 6 Vaccine 0.04 MG/ML [Gardasil]"@en ;
    rdfs:subClassOf obo:VO_0000049, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003938
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003939
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015032
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015040
    ] .

obo:VO_0003934
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1656961" ;
    obo:VO_0003198 1656961 ;
    obo:VO_0003560 "L1 protein, Human papillomavirus type 11 Vaccine / L1 protein, Human papillomavirus type 16 Vaccine / L1 protein, Human papillomavirus type 18 Vaccine / L1 protein, Human papillomavirus type 6 Vaccine Injection [Gardasil]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2344301", "RXAUI: 7250795", "TUI: T200" ;
    rdfs:label "GARDASIL Injection"@en ;
    rdfs:subClassOf obo:VO_0003932 .

obo:VO_0003935
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798274" ;
    obo:VO_0003198 798274 ;
    obo:VO_0003560 "0.5 ML L1 protein, Human papillomavirus type 11 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 16 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 18 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 6 Vaccine 0.04 MG/ML Injection [Gardasil]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1714255", "RXAUI: 7250530, 6836567, 7251909", "TUI: T200" ;
    rdfs:label "GARDASIL 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003934, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003933
    ] .

obo:VO_0003936
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798277" ;
    obo:VO_0003198 798277 ;
    obo:VO_0003560 "L1 protein, Human papillomavirus type 11 Vaccine / L1 protein, Human papillomavirus type 16 Vaccine / L1 protein, Human papillomavirus type 18 Vaccine / L1 protein, Human papillomavirus type 6 Vaccine Prefilled Syringe [Gardasil]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2344303", "RXAUI: 2851356", "TUI: T200" ;
    rdfs:label "GARDASIL Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003932 .

obo:VO_0003937
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798278" ;
    obo:VO_0003198 798278 ;
    obo:VO_0003560 "0.5 ML L1 protein, Human papillomavirus type 11 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 16 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 18 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 6 Vaccine 0.04 MG/ML Prefilled Syringe [Gardasil]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1725928", "RXAUI: 2851357, 2980898, 6836565", "TUI: T200" ;
    rdfs:label "GARDASIL 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003936, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003933
    ] .

obo:VO_0003938
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798265" ;
    obo:VO_0003198 798265 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344294", "RXAUI: 2851343", "TUI: T200" ;
    rdfs:label "L1 protein, Human papillomavirus type 16 Vaccine 0.08 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003303 .

obo:VO_0003939
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798269" ;
    obo:VO_0003198 798269 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344298", "RXAUI: 2851347", "TUI: T200" ;
    rdfs:label "L1 protein, Human papillomavirus type 6 Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003300 .

obo:VO_0003940
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1301885" ;
    obo:VO_0003198 1301885 ;
    a owl:Class ;
    rdfs:comment "CUI: C2724165", "RXAUI: 4627784", "TUI: T116, T121" ;
    rdfs:label "Human papillomavirus type 16, L1 capsid protein (residues 2-471) vaccine"@en ;
    rdfs:subClassOf obo:VO_0003303, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0011559
    ] .

obo:VO_0003941
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1301887" ;
    obo:VO_0003198 1301887 ;
    a owl:Class ;
    rdfs:comment "CUI: C2724167", "RXAUI: 4627786", "TUI: T116, T129, T121" ;
    rdfs:label "Human papillomavirus type 18, L1 capsid protein (residues 2-472) vaccine"@en ;
    rdfs:subClassOf obo:VO_0003302, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0011559
    ] .

obo:VO_0003942
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1301886" ;
    obo:VO_0003198 1301886 ;
    a owl:Class ;
    rdfs:comment "CUI: C2725255", "RXAUI: 4627785", "TUI: T200" ;
    rdfs:label "Human papillomavirus type 16, L1 capsid protein (residues 2-471) vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003940 .

obo:VO_0003943
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1301888" ;
    obo:VO_0003198 1301888 ;
    a owl:Class ;
    rdfs:comment "CUI: C3474821", "RXAUI: 4627787", "TUI: T200" ;
    rdfs:label "Human papillomavirus type 18, L1 capsid protein (residues 2-472) vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003941 .

obo:VO_0003944
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1167355" ;
    obo:VO_0003198 1167355 ;
    a owl:Class ;
    rdfs:comment "CUI: C3221549", "RXAUI: 3832040", "TUI: T200" ;
    rdfs:label "Cervarix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0011559 .

obo:VO_0003945
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1301890" ;
    obo:VO_0003198 1301890 ;
    a owl:Class ;
    rdfs:comment "CUI: C2725256", "RXAUI: 4627789", "TUI: T200" ;
    rdfs:label "Human papillomavirus type 16, L1 capsid protein (residues 2-471) vaccine 0.04 MG/ML / Human papillomavirus type 18, L1 capsid protein (residues 2-472) vaccine 0.04 MG/ML [Cervarix]"@en ;
    rdfs:subClassOf obo:VO_0011559, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003942
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003943
    ] .

obo:VO_0003946
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/867488" ;
    obo:VO_0003198 867488 ;
    obo:VO_0003560 "L1 protein, Human papillomavirus type 16 Vaccine / L1 protein, Human papillomavirus type 18 Vaccine Prefilled Syringe [Cervarix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2723809", "RXAUI: 2999023", "TUI: T200" ;
    rdfs:label "CERVARIX Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003944 .

obo:VO_0003947
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Cervarix Human Papillomavirus bivalent (types 16 and 18) vaccine, recombinant 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1301891" ;
    obo:VO_0003198 1301891 ;
    a owl:Class ;
    rdfs:comment "CUI: C2724157", "RXAUI: 3266660, 4627790, 7236130", "TUI: T200" ;
    rdfs:label "CERVARIX 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003946, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003945
    ] .

obo:VO_0003948
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/845525" ;
    obo:VO_0003198 845525 ;
    a owl:Class ;
    rdfs:comment "CUI: C1579318", "RXAUI: 2963098", "TUI: T129, T121" ;
    rdfs:label "Japanese encephalitis virus vaccine, inactivated"@en ;
    rdfs:subClassOf obo:VO_0000665 .

obo:VO_0003949
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300779" ;
    obo:VO_0003198 1300779 ;
    a owl:Class ;
    rdfs:comment "CUI: C3474322", "RXAUI: 4626258", "TUI: T129, T121" ;
    rdfs:label "Japanese encephalitis virus vaccine Nakayama-NIH strain, inactivated"@en ;
    rdfs:subClassOf obo:VO_0003948, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0011558
    ] .

obo:VO_0003950
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300780" ;
    obo:VO_0003198 1300780 ;
    a owl:Class ;
    rdfs:comment "CUI: C2682867", "RXAUI: 4626259", "TUI: T200" ;
    rdfs:label "Japanese encephalitis virus vaccine Nakayama-NIH strain, inactivated 0.012 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003949 .

obo:VO_0003951
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1167200" ;
    obo:VO_0003198 1167200 ;
    a owl:Class ;
    rdfs:comment "CUI: C3221394", "RXAUI: 3838660", "TUI: T200" ;
    rdfs:label "Ixiaro Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0011558 .

obo:VO_0003952
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300782" ;
    obo:VO_0003198 1300782 ;
    a owl:Class ;
    rdfs:comment "CUI: C2682871", "RXAUI: 4626261", "TUI: T200" ;
    rdfs:label "Japanese encephalitis virus vaccine Nakayama-NIH strain, inactivated 0.012 MG/ML [Ixiaro]"@en ;
    rdfs:subClassOf obo:VO_0011558, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003950
    ] .

obo:VO_0003953
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/845531" ;
    obo:VO_0003198 845531 ;
    obo:VO_0003560 "Japanese encephalitis virus vaccine, inactivated Prefilled Syringe [Ixiaro]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2682872", "RXAUI: 2963104", "TUI: T200" ;
    rdfs:label "Ixiaro (Japanese Encephalitis Vaccine, Inactivated, Adsorbed) Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003951 .

obo:VO_0003954
    obo:IAO_0000118 "Ixiaro (Japanese Encephalitis Vaccine, Inactivated, Adsorbed) 0.012 MG/ML 0.5 ML Prefilled Syringe", "Ixiaro 6 MCG per 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300783" ;
    obo:VO_0003198 1300783 ;
    obo:VO_0003560 "0.5 ML Japanese encephalitis virus vaccine Nakayama-NIH strain, inactivated 0.012 MG/ML Prefilled Syringe [Ixiaro]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2682873", "RXAUI: 6833047, 4626263, 2984288, 4626262, 2994485", "TUI: T200" ;
    rdfs:label "0.5 ML Ixiaro 0.012 MG/ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003953, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003952
    ] .

obo:VO_0003955
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1812935" ;
    obo:VO_0003198 1812935 ;
    a owl:Class ;
    rdfs:comment "CUI: C4291328", "RXAUI: 8262960", "TUI: T116, T129, T121" ;
    rdfs:label "vibrio cholerae CVD 103-HGR strain live antigen"@en ;
    rdfs:subClassOf obo:VO_0000919, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0003082
    ] .

obo:VO_0003956
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1812935" ;
    obo:VO_0003198 1812935 ;
    a owl:Class ;
    rdfs:comment "CUI: C4291328", "RXAUI: 8262960", "TUI: T200" ;
    rdfs:label "vibrio cholerae CVD 103-HGR strain live antigen 12000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0003955 .

obo:VO_0003957
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1812950" ;
    obo:VO_0003198 1812950 ;
    a owl:Class ;
    rdfs:comment "CUI: C4291505", "RXAUI: 8262971", "TUI: T200" ;
    rdfs:label "Vaxchora Oral Product"@en ;
    rdfs:subClassOf obo:VO_0003082 .

obo:VO_0003958
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1172748" ;
    obo:VO_0003198 1172748 ;
    a owl:Class ;
    rdfs:comment "CUI: C3226798", "RXAUI: 3838385", "TUI: T200" ;
    rdfs:label "Infanrix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000064 .

obo:VO_0003959
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/854946" ;
    obo:VO_0003198 854946 ;
    a owl:Class ;
    rdfs:label "pneumococcal capsular polysaccharide type 10A vaccine"@en ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000088
    ] .

obo:VO_0003960
    a owl:Class ;
    rdfs:label "Neisseria meningitidis vaccine antigen"@en ;
    rdfs:subClassOf obo:VO_0000919 .

obo:VO_0003961
    obo:IAO_0000115 "replication defective simian adenoviral vector expressing KH, a self-cleaving polyprotein comprising L. donovani KMP-11 and HASPB" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/28498840" ;
    obo:VO_0001818 5712 ;
    obo:VO_0003147 "KH, a self-cleaving polyprotein comprising L. donovani HASPB and KMP-11 Proteins" ;
    a owl:Class ;
    rdfs:label "ChAd63-KH vaccine"@en ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011157
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011162
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000281 ;
        owl:someValuesFrom obo:VO_0001047
    ] .

obo:VO_0003962
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1812948" ;
    obo:VO_0003198 1812948 ;
    obo:VO_0003560 "Cholera Vaccine Oral Suspension [Vaxchora]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4291477", "RXAUI: 8262969", "TUI: T200" ;
    rdfs:label "Vaxchora Oral Suspension"@en ;
    rdfs:subClassOf obo:VO_0003957 .

obo:VO_0003963
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1812951" ;
    obo:VO_0003198 1812951 ;
    obo:VO_0003560 "vibrio cholerae CVD 103-HGR strain live antigen 12000000 UNT/ML Oral Suspension [Vaxchora]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4271028", "RXAUI: 8262973, 8262974, 8262972", "TUI: T200" ;
    rdfs:label "Vaxchora 1,200,000,000 UNT per 100 ML Oral Suspension"@en ;
    rdfs:subClassOf obo:VO_0003962, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003964
    ] .

obo:VO_0003964
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1812947" ;
    obo:VO_0003198 1812947 ;
    a owl:Class ;
    rdfs:comment "CUI: C4291443", "RXAUI: 8262968", "TUI: T200" ;
    rdfs:label "vibrio cholerae CVD 103-HGR strain live antigen 12000000 UNT/ML [Vaxchora]"@en ;
    rdfs:subClassOf obo:VO_0003082, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003956
    ] .

obo:VO_0003965
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050058" ;
    obo:VO_0003198 2050058 ;
    a owl:Class ;
    rdfs:comment "CUI: C4718905", "RXAUI: 9712930", "TUI: T200" ;
    rdfs:label "Heplisav-B Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003152 .

obo:VO_0003966
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050058" ;
    obo:VO_0003198 2050058 ;
    obo:VO_0003560 "Hepatitis B Surface Antigen Vaccine Prefilled Syringe [Heplisav-B]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4718905", "RXAUI: 10287780", "TUI: T200" ;
    rdfs:label "HEPLISAV-B Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003965 .

obo:VO_0003967
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "0.5 ML Heplisav-B 0.04 MG/ML Prefilled Syringe", "HEPLISAV-B 20 MCG in 0.5 ML Prefilled Syringe", "Heplisav-B 0.04 MG/ML per 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/2050059" ;
    obo:VO_0003198 2050059 ;
    obo:VO_0003560 "0.5 ML Hepatitis B Surface Antigen Vaccine 0.04 MG/ML Prefilled Syringe [Heplisav-B]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4553167", "RXAUI: 10287788, 10287789, 10287781, 10287783, 10287782", "TUI: T200" ;
    rdfs:label "HEPLISAV-B 20 MCG per 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003966, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003968
    ] .

obo:VO_0003968
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1994349" ;
    obo:VO_0003198 1994349 ;
    a owl:Class ;
    rdfs:comment "CUI: C4541386", "RXAUI: 9712928", "TUI: T200" ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine 0.04 MG/ML [Heplisav-B]"@en ;
    rdfs:subClassOf obo:VO_0003152, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003230
    ] .

obo:VO_0003969
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/801829" ;
    obo:VO_0003198 801829 ;
    a owl:Class ;
    rdfs:comment "CUI: C2346335", "RXAUI: 5027208", "TUI: T200" ;
    rdfs:label "Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 68 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0015014 .

obo:VO_0003970
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1184583" ;
    obo:VO_0003198 1184583 ;
    a owl:Class ;
    rdfs:comment "CUI: C3238386", "RXAUI: 3843263", "TUI: T200" ;
    rdfs:label "Pentacel Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000084 .

obo:VO_0003971
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/805376" ;
    obo:VO_0003198 805376 ;
    a owl:Class ;
    rdfs:comment "CUI: C2364460", "RXAUI: 5027344", "TUI: T200" ;
    rdfs:label "acellular pertussis vaccine, inactivated 96 UNT/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 68 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML [Pentacel]"@en ;
    rdfs:subClassOf obo:VO_0000084, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003392
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003395
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003401
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003843
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003844
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003969
    ] .

obo:VO_0003972
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657397" ;
    obo:VO_0003198 1657397 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Injection [Pentacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033845", "RXAUI: 7251281", "TUI: T200" ;
    rdfs:label "Pentacel vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003970 .

obo:VO_0003973
    obo:IAO_0000118 "Pentacel DTaP-IPV/Hib (Diphtheria and Tetanus Toxoids and Acellular Pertussis, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate)) 0.5 ML Injection" ;
    obo:VO_0003198 805378 ;
    obo:VO_0003560 "0.5 ML acellular pertussis vaccine, inactivated 96 UNT/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 68 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Injection [Pentacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2346346", "RXAUI: 7251683, 7253749, 7250887", "TUI: T200" ;
    rdfs:label "Pentacel vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003972, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003971
    ] .

obo:VO_0003974
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1171400" ;
    obo:VO_0003198 1171400 ;
    a owl:Class ;
    rdfs:comment "CUI: C3225481", "RXAUI: 3838975", "TUI: T200" ;
    rdfs:label "Kinrix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000067 .

obo:VO_0003975
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830550" ;
    obo:VO_0003198 830550 ;
    a owl:Class ;
    rdfs:comment "CUI: C2586836", "RXAUI: 5027347", "TUI: T200" ;
    rdfs:label "acellular pertussis vaccine, inactivated 0.116 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML [Kinrix]"@en ;
    rdfs:subClassOf obo:VO_0000067, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003391
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003401
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003456
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003843
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003844
    ] .

obo:VO_0003976
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657886" ;
    obo:VO_0003198 1657886 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033746", "RXAUI: 7251903", "TUI: T200" ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.05 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.05 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML [Kinrix]"@en ;
    rdfs:subClassOf obo:VO_0000067, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003203
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003207
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003386
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003401
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003456
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003843
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003844
    ] .

obo:VO_0003977
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830556" ;
    obo:VO_0003198 830556 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Prefilled Syringe [Kinrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2586841", "RXAUI: 5027411", "TUI: T200" ;
    rdfs:label "KINRIX vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003974 .

obo:VO_0003978
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "KINRIX DTaP-IPV (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine) 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/830557" ;
    obo:VO_0003198 830557 ;
    obo:VO_0003560 "0.5 ML acellular pertussis vaccine, inactivated 0.116 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Prefilled Syringe [Kinrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2586842", "RXAUI: 7253751, 5027675, 3634544", "TUI: T200" ;
    rdfs:label "KINRIX vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003977, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003975
    ] .

obo:VO_0003979
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657887" ;
    obo:VO_0003198 1657887 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Injection [Kinrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2586837", "RXAUI: 7251904", "TUI: T200" ;
    rdfs:label "KINRIX vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003974 .

obo:VO_0003980
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "KINRIX DTaP-IPV (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine) 0.5 ML Injection" ;
    obo:VO_0003198 830552 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.05 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.05 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Injection [Kinrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2586838", "RXAUI: 7250882, 7251905, 7253750", "TUI: T200" ;
    rdfs:label "KINRIX vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003979, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003976
    ] .

obo:VO_0003981
    obo:VO_0003198 1168164 ;
    a owl:Class ;
    rdfs:comment "CUI: C3222333", "RXAUI: 3833478", "TUI: T200", "http://purl.bioontology.org/ontology/RXNORM/1168164" ;
    rdfs:label "Daptacel Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000029 .

obo:VO_0003982
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300309" ;
    obo:VO_0003198 1300309 ;
    obo:VO_0003560 "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.01 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.02 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Daptacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2609933", "RXAUI: 5027355", "TUI: T200" ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.01 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.02 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Daptacel]"@en ;
    rdfs:subClassOf obo:VO_0000029, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003204
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003209
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003352
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003374
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003385
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003395
    ] .

obo:VO_0003983
    obo:IAO_0000118 "Daptacel DTaP (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300310" ;
    obo:VO_0003198 1300310 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.01 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.02 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection [Daptacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1169838", "RXAUI: 7251885, 7250857, 7250858, 7253754", "TUI: T200" ;
    rdfs:label "DAPTACEL vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003981, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003982
    ] .

obo:VO_0003984
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1169952" ;
    obo:VO_0003198 1169952 ;
    a owl:Class ;
    rdfs:comment "CUI: C3224088", "RXAUI: 3828634", "TUI: T200" ;
    rdfs:label "Adacel Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000005 .

obo:VO_0003985
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300190" ;
    obo:VO_0003198 1300190 ;
    a owl:Class ;
    rdfs:comment "CUI: C2587006", "RXAUI: 5027353", "TUI: T200" ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.01 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.005 MG/ML / diphtheria toxoid vaccine, inactivated 4 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Adacel]"@en ;
    rdfs:subClassOf obo:VO_0000005, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003204
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003208
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003352
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003374
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003385
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003429
    ] .

obo:VO_0003986
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/904262" ;
    obo:VO_0003198 904262 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Prefilled Syringe [Adacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2746860", "RXAUI: 5027415", "TUI: T200" ;
    rdfs:label "Adacel Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003984 .

obo:VO_0003987
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300191" ;
    obo:VO_0003198 1300191 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.01 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.005 MG/ML / diphtheria toxoid vaccine, inactivated 4 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Prefilled Syringe [Adacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2746861", "RXAUI: 4625204, 7252705, 5027658, 4625563", "TUI: T200" ;
    rdfs:label "Adacel 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003986, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003985
    ] .

obo:VO_0003988
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657767" ;
    obo:VO_0003198 1657767 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Injection [Adacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033829", "RXAUI: 7251690", "TUI: T200" ;
    rdfs:label "Adacel Injection"@en ;
    rdfs:subClassOf obo:VO_0003984 .

obo:VO_0003989
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Adacel (Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 5 MCG / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 5 MCG / Bordetella pertussis pertactin vaccine, inactivated 3 MCG / Bordetella pertussis toxoid vaccine, inactivated 2.5 MCG / Diphtheria Toxoid Vaccine 2 UNT / Tetanus Toxoid Vaccine 5 UNT) per 0.5 ML Injection", "Adacel Tdap (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed) Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300206" ;
    obo:VO_0003198 1300206 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.01 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.005 MG/ML / diphtheria toxoid vaccine, inactivated 4 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection [Adacel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1639148", "RXAUI: 7250855, 7251691, 7252702, 7250854", "TUI: T200" ;
    rdfs:label "Adacel 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003988, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003985
    ] .

obo:VO_0003990
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300383" ;
    a owl:Class ;
    rdfs:comment 1300383, "CUI: C3152863", "RXAUI: 5027354", "TUI: T200" ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.05 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.05 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML [Infanrix]"@en ;
    rdfs:subClassOf obo:VO_0000064, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003203
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003207
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003386
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003401
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003456
    ] .

obo:VO_0003991
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657878" ;
    obo:VO_0003198 1657878 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Injection [Infanrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2368976", "RXAUI: 7251893", "TUI: T200" ;
    rdfs:label "INFANRIX vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003958 .

obo:VO_0003992
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Infanrix (Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.025 MG / Bordetella pertussis pertactin vaccine, inactivated 0.008 MG / Bordetella pertussis toxoid vaccine, inactivated 0.025 MG / diphtheria toxoid vaccine, inactivated 25 UNT / tetanus toxoid vaccine, inactivated 10 UNT) per 0.5 ML Injection", "Infanrix DTaP (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300386" ;
    obo:VO_0003198 1300386 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.05 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.05 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Injection [Infanrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C0710622", "RXAUI: 7250871, 7251894, 7250870, 7253756", "TUI: T200" ;
    rdfs:label "INFANRIX vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003991, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003990
    ] .

obo:VO_0003993
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/824539" ;
    obo:VO_0003198 824539 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Prefilled Syringe [Infanrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2368973", "RXAUI: 5027387", "TUI: T200" ;
    rdfs:label "INFANRIX vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003958 .

obo:VO_0003994
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Infanrix (Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 25 MCG / Bordetella pertussis pertactin vaccine, inactivated 8 MCG / Bordetella pertussis toxoid vaccine, inactivated 25 MCG / diphtheria toxoid vaccine, inactivated 25 UNT / tetanus toxoid vaccine, inactivated 10 UNT) per 0.5 ML Prefilled Syringe", "Infanrix DTaP (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300384" ;
    obo:VO_0003198 1300384 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.05 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.05 MG/ML / diphtheria toxoid vaccine, inactivated 50 UNT/ML / tetanus toxoid vaccine, inactivated 20 UNT/ML Prefilled Syringe [Infanrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2368974", "RXAUI: 5027659, 7253755, 3633959, 4625557", "TUI: T200" ;
    rdfs:label "INFANRIX vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003993, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003990
    ] .

obo:VO_0003995
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1175718" ;
    obo:VO_0003198 1175718 ;
    a owl:Class ;
    rdfs:comment "CUI: C3229697", "RXAUI: 3831021", "TUI: T200" ;
    rdfs:label "Boostrix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000015 .

obo:VO_0003996
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657603" ;
    obo:VO_0003198 1657603 ;
    a owl:Class ;
    rdfs:comment "CUI: C4033749", "RXAUI: 7251494", "TUI: T200" ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.005 UNT/ML / Bordetella pertussis toxoid vaccine, inactivated 0.016 MG/ML / diphtheria toxoid vaccine, inactivated 5 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Boostrix]"@en ;
    rdfs:subClassOf obo:VO_0000015, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003205
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003206
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003383
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003385
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003387
    ] .

obo:VO_0003997
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300369" ;
    obo:VO_0003198 1300369 ;
    a owl:Class ;
    rdfs:comment "CUI: C2364904", "RXAUI: 5027356", "TUI: T200" ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.005 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.016 MG/ML / diphtheria toxoid vaccine, inactivated 5 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Boostrix]"@en ;
    rdfs:subClassOf obo:VO_0000015, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003206
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003383
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003385
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003387
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004207
    ] .

obo:VO_0003998
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Injection [Boostrix]", "http://purl.bioontology.org/ontology/RXNORM/1657466" ;
    obo:VO_0003198 1657466 ;
    a owl:Class ;
    rdfs:comment "CUI: C2364905", "RXAUI: 7251319", "TUI: T200" ;
    rdfs:label "BOOSTRIX vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0003995 .

obo:VO_0003999
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Boostrix (Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 8 MCG / Bordetella pertussis pertactin vaccine, inactivated 2.5 MCG / Bordetella pertussis toxoid vaccine, inactivated 8 MCG / diphtheria toxoid vaccine, inactivated 2.5 UNT / tetanus toxoid vaccine, inactivated 5 UNT) per 0.5 ML Injection", "Boostrix Tdap (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed) Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300378" ;
    obo:VO_0003198 1300378 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.005 UNT/ML / Bordetella pertussis toxoid vaccine, inactivated 0.016 MG/ML / diphtheria toxoid vaccine, inactivated 5 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection [Boostrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2364906", "RXAUI: 7250865, 7251497, 7253758, 7250866", "TUI: T200" ;
    rdfs:label "BOOSTRIX vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0003998, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003996
    ] .

obo:VO_0004000
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis bp26 mutant vaccine" ;
    rdfs:seeAlso "violinID: 3259" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001039 ;
        owl:someValuesFrom obo:VO_0002561
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004001
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis omp25 mutant vaccine" ;
    rdfs:seeAlso "violinID: 3261" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001039 ;
        owl:someValuesFrom obo:VO_0002566
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004002
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis omp31 mutant vaccine" ;
    rdfs:seeAlso "violinID: 3262" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001039 ;
        owl:someValuesFrom obo:VO_0002567
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004003
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Pseudorabies recombinant vector vaccine encoding gp50 protein" ;
    rdfs:seeAlso "violinID: 826" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:VO_0001093
                [
                    a owl:Restriction ;
                    owl:onProperty obo:BFO_0000051 ;
                    owl:someValuesFrom obo:VO_0002736
                ]
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004004
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BoNT/C" ;
    rdfs:seeAlso "violinID: 91" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010905
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004005
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae CbpA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 787" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011203
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004006
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae ClpP protein Vaccine" ;
    rdfs:seeAlso "violinID: 789" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011193
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004007
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae PspA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 795" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011204
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004008
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae SrtA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 798" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004009
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. caninum NcPDI Protein Vaccine" ;
    rdfs:seeAlso "violinID: 937" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011191
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] .

obo:VO_0004010
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. caninum NcDG1 protein vaccine" ;
    rdfs:seeAlso "violinID: 944" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011202
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] .

obo:VO_0004011
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. meningitidis ExbB Protein Vaccine" ;
    rdfs:seeAlso "violinID: 947" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011186
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0004012
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. meningitidis LctP Protein Vaccine" ;
    rdfs:seeAlso "violinID: 948" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011185
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0004013
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. meningitidis NspA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 956" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011184
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0004014
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. miningitidis TBP2 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 957" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011182
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0004015
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding HA from Influenza A virus (A/Hong Kong/1/68(H3N2))" ;
    rdfs:seeAlso "violinID: 998" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011120
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004016
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding HA from Influenza A virus (A/environment/Hong Kong/156/1997(H5N1))" ;
    rdfs:seeAlso "violinID: 999" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011121
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004017
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus HA protein vaccine (Influenza A virus (A/Yamagata/120/1986(H1N1)))" ;
    rdfs:seeAlso "violinID: 1003" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011126
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004018
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus HA protein vaccine (Influenza A virus (A/Fukuoka/C29/85(H3N2)))" ;
    rdfs:seeAlso "violinID: 1004" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004019
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding HA from Influenza B virus (B/Ibaraki/2/85)" ;
    rdfs:seeAlso "violinID: 1005" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011129
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004020
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding HA from Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))" ;
    rdfs:seeAlso "violinID: 1012" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011140
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004021
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding HA from Influenza A virus (A/equine/Kentucky/1/1981(H3N8))" ;
    rdfs:seeAlso "violinID: 1014" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011302
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004022
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. donovani GRP-78 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1029" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011152
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004023
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. donovani Beta-tubulin Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1031" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011155
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004024
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. pallidum GlpQ Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1069" ;
    rdfs:subClassOf obo:VO_0001230, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012399
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_160
    ] .

obo:VO_0004025
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. pallidum TmpB Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1070" ;
    rdfs:subClassOf obo:VO_0001230, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012400
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_160
    ] .

obo:VO_0004026
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. pallidum Tp92 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1071" ;
    rdfs:subClassOf obo:VO_0001230, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012401
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_160
    ] .

obo:VO_0004027
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. burgdorferi DbpA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1072" ;
    rdfs:subClassOf obo:VO_0000764, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012387
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0004028
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. burgdorferi OspA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1074" ;
    rdfs:subClassOf obo:VO_0000764, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0004029
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. burgdorferi OspB Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1075" ;
    rdfs:subClassOf obo:VO_0000764, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012385
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0004030
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. burgdorferi OspC Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1076" ;
    rdfs:subClassOf obo:VO_0000764, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012386
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0004031
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. monocytogenes DNA Vaccine encoding hly" ;
    rdfs:seeAlso "violinID: 1077" ;
    rdfs:subClassOf obo:VO_0002500, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012388
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1639
    ] .

obo:VO_0004032
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. monocytogenes p60 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1078" ;
    rdfs:subClassOf obo:VO_0002500, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012404
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1639
    ] .

obo:VO_0004033
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. donovani Hsp70 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1109" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011156
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004034
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "F. tularensis FopB Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1111" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011070
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_263
    ] .

obo:VO_0004035
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA vaccine ESAT-6" ;
    rdfs:seeAlso "violinID: 3543" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012368
    ] .

obo:VO_0004036
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus DNA vaccine EBOV GP" ;
    rdfs:seeAlso "violinID: 3576" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010858
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004037
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus EBOV NP" ;
    rdfs:seeAlso "violinID: 3577" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010859
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004038
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Nontypeable H. influenzae NucA Protein vaccine" ;
    rdfs:seeAlso "violinID: 192" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012405
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_727
    ] .

obo:VO_0004039
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Psuedorabies DNA vaccine encoding IE180 protein" ;
    rdfs:seeAlso "violinID: 822" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011242
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004040
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Pseudorabies Subunit gI Protein Vaccine" ;
    rdfs:seeAlso "violinID: 829" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011251
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004041
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Pseudorabies Subunit gB Protein Vaccine" ;
    rdfs:seeAlso "violinID: 830" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011238
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004042
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. neurona SAG1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 835" ;
    rdfs:subClassOf obo:VO_0000935, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011253
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_42890
    ] .

obo:VO_0004043
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Rotavirus VP6 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 877" ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011222
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10912
    ] .

obo:VO_0004044
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. major PSA-2 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1006" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011279
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004045
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. major H2B Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1009" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011277
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004046
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. major DNA Vaccine encoding Gp63" ;
    rdfs:seeAlso "violinID: 1013" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011278
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004047
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. aureus ClfA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1082" ;
    rdfs:subClassOf obo:VO_0002502, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012390
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0004048
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. aureus CNA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1083" ;
    rdfs:subClassOf obo:VO_0002502, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012389
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0004049
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. aureus FnbA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1084" ;
    rdfs:subClassOf obo:VO_0002502, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012392
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0004050
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. agalactiae BPS Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1086" ;
    rdfs:subClassOf obo:VO_0001375, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012393
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1311
    ] .

obo:VO_0004051
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. agalactiae Rib Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1087" ;
    rdfs:subClassOf obo:VO_0001375, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012403
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1311
    ] .

obo:VO_0004052
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. agalactiae Sip Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1088" ;
    rdfs:subClassOf obo:VO_0001375, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012402
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1311
    ] .

obo:VO_0004053
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pyogenes Emm1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1089" ;
    rdfs:subClassOf obo:VO_0002852, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012397
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0004054
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pyogenes FbaA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1090" ;
    rdfs:subClassOf obo:VO_0002852, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012396
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0004055
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pyogenes FBP54 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1091" ;
    rdfs:subClassOf obo:VO_0002852, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012395
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0004056
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pyogenes SfbI Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1092" ;
    rdfs:subClassOf obo:VO_0002852, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012394
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0004057
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pyogenes Sib35 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1093" ;
    rdfs:subClassOf obo:VO_0002852, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012398
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0004058
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA Vaccine encoding KatG" ;
    rdfs:seeAlso "violinID: 1094" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012369
    ] .

obo:VO_0004059
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis HBHA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1095" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012373
    ] .

obo:VO_0004060
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. pylori HspA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1097" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012377
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004061
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. pylori HspB Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1098" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012378
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004062
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. pylori GltA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1099" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012379
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004063
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae PhpA-79 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1100" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012383
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004064
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. meningitidis TbpA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1101" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0012380
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0004065
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. berghei MSP1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1105" ;
    rdfs:subClassOf obo:VO_0002513, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011225
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004066
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. infantum SMT Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1108" ;
    rdfs:subClassOf obo:VO_0012159, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011282
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5671
    ] .

obo:VO_0004067
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. donovani HASPB1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1028" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0011162
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004068
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae GtS Protein Vaccine" ;
    rdfs:seeAlso "violinID: 790" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004069
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae 6PGD Protein Vaccine" ;
    rdfs:seeAlso "violinID: 792" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004070
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae PiaA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 793" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004071
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae RASV synthesizing PsaA" ;
    rdfs:seeAlso "violinID: 794" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004072
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant adenovirus vector vaccine ADV-GP/NP" ;
    rdfs:seeAlso "violinID: 61" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004073
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "GP and NP" ;
    rdfs:seeAlso "violinID: 71" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004074
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BoNT/A(Hc)" ;
    rdfs:seeAlso "violinID: 74" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004075
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PBT" ;
    rdfs:seeAlso "violinID: 75" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004076
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BoNT/F(Hc)" ;
    rdfs:seeAlso "violinID: 76" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004077
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BoNT/B(Hc)" ;
    rdfs:seeAlso "violinID: 78" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004078
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VRP" ;
    rdfs:seeAlso "violinID: 82" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004079
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "V-LSN" ;
    rdfs:seeAlso "violinID: 83" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004080
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "V-LSG" ;
    rdfs:seeAlso "violinID: 84" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004081
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "V-LSG1 + V- LSG2" ;
    rdfs:seeAlso "violinID: 85" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004082
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "V-LSG + V-LSN" ;
    rdfs:seeAlso "violinID: 86" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004083
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "V-LSG/N" ;
    rdfs:seeAlso "violinID: 87" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004084
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HC of type C and D" ;
    rdfs:seeAlso "violinID: 88" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004085
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ML29" ;
    rdfs:seeAlso "violinID: 89" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004086
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "V-LSGPC" ;
    rdfs:seeAlso "violinID: 90" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004087
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VSV[Delta]G/LVGPC" ;
    rdfs:seeAlso "violinID: 92" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004088
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "YFV17D/LAS-GPC" ;
    rdfs:seeAlso "violinID: 93" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004089
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ACAM1000" ;
    rdfs:seeAlso "violinID: 95" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004090
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CCSV" ;
    rdfs:seeAlso "violinID: 97" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004091
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "LC16m8" ;
    rdfs:seeAlso "violinID: 98" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004092
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MVA" ;
    rdfs:seeAlso "violinID: 99" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004093
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC" ;
    rdfs:seeAlso "violinID: 100" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004094
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "dVV-L" ;
    rdfs:seeAlso "violinID: 101" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004095
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IMV-EEV" ;
    rdfs:seeAlso "violinID: 102" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004096
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Smallpox DNA Vaccine" ;
    rdfs:seeAlso "violinID: 103" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004097
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MVA-BN" ;
    rdfs:seeAlso "violinID: 106" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004098
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "LC16m0" ;
    rdfs:seeAlso "violinID: 107" ;
    rdfs:subClassOf obo:VO_0000651, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004099
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pABFHc2" ;
    rdfs:seeAlso "violinID: 108" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004100
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Inactivated C. jejuni whole-cell (CWC)" ;
    rdfs:seeAlso "violinID: 114" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197
    ] .

obo:VO_0004101
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MBP fused on Campylobacter FlaA (MBP-FlaA)" ;
    rdfs:seeAlso "violinID: 124" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197
    ] .

obo:VO_0004102
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant DOBV nucleocapsid protein (rDOBV N)" ;
    rdfs:seeAlso "violinID: 140" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11598
    ] .

obo:VO_0004103
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Truncated Recombinant DoBV Nucleocapsid Proteins (Dob-N rNp)" ;
    rdfs:seeAlso "violinID: 141" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11598
    ] .

obo:VO_0004104
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VEE virus complex-specific monoclonal antibody" ;
    rdfs:seeAlso "violinID: 167" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004105
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Live attenuated vaccine TC-83" ;
    rdfs:seeAlso "violinID: 168" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004106
    obo:IAO_0000117 "RS, NF, YH" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=172", "https://www.ncbi.nlm.nih.gov/pubmed/15196215" ;
    a owl:Class ;
    rdfs:label "MVA85A prime and BCG boost" ;
    rdfs:seeAlso "violinID: 172" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Class ;
        owl:intersectionOf ([
                a owl:Restriction ;
                owl:onProperty obo:VO_0003127 ;
                owl:someValuesFrom obo:VO_0003120
            ]
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003128 ;
                owl:someValuesFrom obo:VO_0000771
            ]
        )
    ] .

obo:VO_0004107
    obo:IAO_0000117 "RS, NF, YH" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=174" ;
    a owl:Class ;
    rdfs:label "BCG expressing MSP" ;
    rdfs:seeAlso "violinID: 174" ;
    rdfs:subClassOf obo:VO_0003130 .

obo:VO_0004108
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Mtb72f fusion protein" ;
    rdfs:seeAlso "violinID: 175" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004109
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant RNA replicons from attenuated VEE virus" ;
    rdfs:seeAlso "violinID: 181" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004110
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Nontypeable H. influenzae Outer Membrane Protein P1 vaccine" ;
    rdfs:seeAlso "violinID: 182" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_727
    ] .

obo:VO_0004111
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chimeric SIN/VEE Virus SIN-83" ;
    rdfs:seeAlso "violinID: 183" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004112
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Live attenuated VEE vaccines" ;
    rdfs:seeAlso "violinID: 184" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004113
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Live attenuated V3526 virus" ;
    rdfs:seeAlso "violinID: 185" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004114
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Nontypeable H. influenzae outer membrane recombinant P4 vaccine" ;
    rdfs:seeAlso "violinID: 187" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_727
    ] .

obo:VO_0004115
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Non-typeable H. influenzae dLOS–P6 vaccine" ;
    rdfs:seeAlso "violinID: 196" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_727
    ] .

obo:VO_0004116
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Defective adenovirus expressing VEEV E2 glycoprotein" ;
    rdfs:seeAlso "violinID: 197" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004117
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus-like particles" ;
    rdfs:seeAlso "violinID: 216" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004118
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Adenovirus vectors expressing Marburg virus glycoprotein" ;
    rdfs:seeAlso "violinID: 217" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004119
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine encoding ANDV glycoproteins" ;
    rdfs:seeAlso "violinID: 218" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11598
    ] .

obo:VO_0004120
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chimaeric HBV core particles carrying Puumala virus nucleocapsid protein fragments" ;
    rdfs:seeAlso "violinID: 219" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11598
    ] .

obo:VO_0004121
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Avirulent Salmonella vaccine strain carrying C. jejuni cjaA gene" ;
    rdfs:seeAlso "violinID: 220" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197
    ] .

obo:VO_0004122
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BCG auxotroph expressing HIV-1 clade immunogen" ;
    rdfs:seeAlso "violinID: 224" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004123
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA vaccine pAK4-sod" ;
    rdfs:seeAlso "violinID: 225" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004124
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "deltaphoP/Q S. typhimurium strains expressing PEB1-ss" ;
    rdfs:seeAlso "violinID: 226" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197
    ] .

obo:VO_0004125
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant VEE Replicons expressing MBGV GP" ;
    rdfs:seeAlso "violinID: 227" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004126
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant VEE Replicons expressing MBGV NP" ;
    rdfs:seeAlso "violinID: 228" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004127
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Irradiated MBGV antigen" ;
    rdfs:seeAlso "violinID: 229" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004128
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus glycoprotein expressed by baculovirus recombinants" ;
    rdfs:seeAlso "violinID: 230" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004129
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Q-VAX" ;
    rdfs:seeAlso "violinID: 237" ;
    rdfs:subClassOf obo:VO_0000463, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_777
    ] .

obo:VO_0004130
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Multivalent DNA vaccine for B. anthracis, Ebola virus, Marburg virus, and VEE virus" ;
    rdfs:seeAlso "violinID: 238" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004131
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M-44" ;
    rdfs:seeAlso "violinID: 240" ;
    rdfs:subClassOf obo:VO_0000463, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_777
    ] .

obo:VO_0004132
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chloroform-methanol residue (CMR)" ;
    rdfs:seeAlso "violinID: 241" ;
    rdfs:subClassOf obo:VO_0000463, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_777
    ] .

obo:VO_0004133
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P1-HspB (fusion of protein 1 and heat-shock protein B)" ;
    rdfs:seeAlso "violinID: 242" ;
    rdfs:subClassOf obo:VO_0000463, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_777
    ] .

obo:VO_0004134
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Coxevac" ;
    rdfs:seeAlso "violinID: 243" ;
    rdfs:subClassOf obo:VO_0000463, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_777
    ] .

obo:VO_0004135
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chlamyvax FQ" ;
    rdfs:seeAlso "violinID: 244" ;
    rdfs:subClassOf obo:VO_0000463, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_777
    ] .

obo:VO_0004136
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VSV-based vaccine expressing MBGV GP" ;
    rdfs:seeAlso "violinID: 245" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004137
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Heterologous MARV Protein VLP" ;
    rdfs:seeAlso "violinID: 246" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004138
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CVD 909" ;
    rdfs:seeAlso "violinID: 250" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004139
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CVD 915" ;
    rdfs:seeAlso "violinID: 253" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004140
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Broilact Chick Salmonella vaccine" ;
    rdfs:seeAlso "violinID: 255" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004141
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Zoosaloral H." ;
    rdfs:seeAlso "violinID: 256" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004142
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Salmonella vacT" ;
    rdfs:seeAlso "violinID: 257" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004143
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. flexneri 2a strain CVD 1205" ;
    rdfs:seeAlso "violinID: 261" ;
    rdfs:subClassOf obo:VO_0000769, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_620
    ] .

obo:VO_0004144
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. coli heat-labile enterotoxin B-subunit (LB-T) Vaccine" ;
    rdfs:seeAlso "violinID: 276" ;
    rdfs:subClassOf obo:VO_0000041, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ] .

obo:VO_0004145
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Shiga Toxin 2 B Subunit Vaccine" ;
    rdfs:seeAlso "violinID: 282" ;
    rdfs:subClassOf obo:VO_0000041, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ] .

obo:VO_0004146
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Brucella ovis Microparticle Subunit Vaccine" ;
    rdfs:seeAlso "violinID: 296" ;
    rdfs:subClassOf obo:VO_0002925, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_236
    ] .

obo:VO_0004147
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Live, Attenuated Rifampin-Resistant Rough Mutants of Brucella melitensis" ;
    rdfs:seeAlso "violinID: 297" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004148
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine co-expressing A85A and caspase-3" ;
    rdfs:seeAlso "violinID: 303" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1773
    ] .

obo:VO_0004149
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant vaccinia A27L, D8L, and B5R Proteins with adjuvant MPL-TDM" ;
    rdfs:seeAlso "violinID: 305" ;
    rdfs:subClassOf obo:VO_0003060, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004150
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Killed Vaccinia Virus with Adjuvant NanoEmulsion" ;
    rdfs:seeAlso "violinID: 311" ;
    rdfs:subClassOf obo:VO_0003060, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10255
    ] .

obo:VO_0004151
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Yellow Fever NS1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 781" ;
    rdfs:subClassOf obo:VO_0000123, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11089
    ] .

obo:VO_0004152
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "vP869" ;
    rdfs:seeAlso "violinID: 783" ;
    rdfs:subClassOf obo:VO_0000123, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11089
    ] .

obo:VO_0004153
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Varicella Subunit Vaccine encoding gI and gE glycoproteins" ;
    rdfs:seeAlso "violinID: 785" ;
    rdfs:subClassOf obo:VO_0000669, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10335
    ] .

obo:VO_0004154
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "TBEV DNA vaccine encoding E protein" ;
    rdfs:seeAlso "violinID: 814" ;
    rdfs:subClassOf obo:VO_0012190, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11084
    ] .

obo:VO_0004155
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Pseduorabies Subunit Glycoprotein C Vaccine" ;
    rdfs:seeAlso "violinID: 820" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004156
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Pseudorabies recombinant vector vaccine encoding gp50 and gII protein" ;
    rdfs:seeAlso "violinID: 827" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004157
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Y. pestis YscF Protein Vaccine" ;
    rdfs:seeAlso "violinID: 886" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004158
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Y. pestis DNA vaccine encoding dfF1 Protein" ;
    rdfs:seeAlso "violinID: 906" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004159
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RASV expressing Y. pestis Psn" ;
    rdfs:seeAlso "violinID: 908" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004160
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Rotavirus VP2/VP 6 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 914" ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10912
    ] .

obo:VO_0004161
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Rotavirus VP4/VP7 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 917" ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10912
    ] .

obo:VO_0004162
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. yoelii DNA vaccine encoding PyHEP17 Protein" ;
    rdfs:seeAlso "violinID: 927" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004163
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. caninum DNA vaccine encoding NcSAG1 and NcSRS2, combined with recombinant NcSAG1 and NcSRS2 Proteins" ;
    rdfs:seeAlso "violinID: 935" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] .

obo:VO_0004164
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. caninum MIC10 and p24 protein vaccine" ;
    rdfs:seeAlso "violinID: 946" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] .

obo:VO_0004165
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CCPS-P64kR" ;
    rdfs:seeAlso "violinID: 953" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0004166
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C. botulinum DNA vaccine pSCARSA/BHc" ;
    rdfs:seeAlso "violinID: 983" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0004167
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding HA of Equine influenza virus H3N8" ;
    rdfs:seeAlso "violinID: 991" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004168
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant vesicular stomatitis virus encoding HA from Influenza A virus (A/WSN/1933(H1N1))" ;
    rdfs:seeAlso "violinID: 992" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004169
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant baculovirus encoding HA from Influenza A virus (A/Puerto Rico/8/1934(H1N1))" ;
    rdfs:seeAlso "violinID: 995" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004170
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant vaccinia virus encoding HA from Influenza B virus (Strain B/England/222/82)" ;
    rdfs:seeAlso "violinID: 996" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004171
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. major DNA Vaccine encoding LACKp24, TSA, LmSTI1 and CPa" ;
    rdfs:seeAlso "violinID: 1000" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004172
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. major DNA Vaccine encoding SP" ;
    rdfs:seeAlso "violinID: 1001" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004173
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pCAGGoptiHA" ;
    rdfs:seeAlso "violinID: 1002" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004174
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BacHA derived from Influenza A virus (A/Indonesia/CDC669/2006(H5N1))" ;
    rdfs:seeAlso "violinID: 1007" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004175
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Flagellin-based HA globular head fusion vaccine using HA protein from Influenza A virus (A/Viet Nam/1203/2004(H5N1))" ;
    rdfs:seeAlso "violinID: 1010" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004176
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. major H1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1011" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004177
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding M1 from Influenza A virus (A/chicken/Henan/12/2004(H5N1))" ;
    rdfs:seeAlso "violinID: 1015" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004178
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "AdH5-FluA NP" ;
    rdfs:seeAlso "violinID: 1021" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004179
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. donovani LD31 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1030" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004180
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Leishmania vaccine using recombinant L. tarentolae strain expressing A2 antigen" ;
    rdfs:seeAlso "violinID: 1032" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004181
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. annulata Tams1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1055" ;
    rdfs:subClassOf obo:VO_0000909, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5874
    ] .

obo:VO_0004182
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. typhi DnaJ Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1056" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004183
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. typhi GroEL Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1057" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004184
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Salmonella IroN Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1060" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004185
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Salmonella DNA vaccine encoding SopB Protein" ;
    rdfs:seeAlso "violinID: 1062" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004186
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. typimurium Vi4072" ;
    rdfs:seeAlso "violinID: 1063" ;
    rdfs:subClassOf obo:VO_0000768, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_590
    ] .

obo:VO_0004187
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Measles Virus vaccine VEE/SIN-H" ;
    rdfs:seeAlso "violinID: 1068" ;
    rdfs:subClassOf obo:VO_0000654, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11234
    ] .

obo:VO_0004188
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. burgdorferi DbpA and OspA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1073" ;
    rdfs:subClassOf obo:VO_0000764, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0004189
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. aeruginosa DNA Vaccine encoding OprF" ;
    rdfs:seeAlso "violinID: 1079" ;
    rdfs:subClassOf obo:VO_0000393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0004190
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. aeruginosa OprI Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1080" ;
    rdfs:subClassOf obo:VO_0000393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0004191
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. aeruginosa PcrV Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1081" ;
    rdfs:subClassOf obo:VO_0000393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0004192
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. aureus DNA Vaccine encoding PBP2a Protein" ;
    rdfs:seeAlso "violinID: 1085" ;
    rdfs:subClassOf obo:VO_0002502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0004193
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum LSA-3 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1096" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004194
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. chabaudi AMA1 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1102" ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004195
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum CS expressed in irradiated P. berghei as Vaccine" ;
    rdfs:seeAlso "violinID: 1103" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004196
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum DNA Vaccine encoding EBA-175" ;
    rdfs:seeAlso "violinID: 1104" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004197
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pcDNA3-LiP0" ;
    rdfs:seeAlso "violinID: 1106" ;
    rdfs:subClassOf obo:VO_0012159, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5671
    ] .

obo:VO_0004198
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VVr expressing L. infantum P36/LACK" ;
    rdfs:seeAlso "violinID: 1107" ;
    rdfs:subClassOf obo:VO_0012159, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5671
    ] .

obo:VO_0004199
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. amazonensis CP Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1110" ;
    rdfs:subClassOf obo:VO_0012158, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5659
    ] .

obo:VO_0004200
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. agalactiae BipA Protein Vaccine" ;
    rdfs:seeAlso "violinID: 1112" ;
    rdfs:subClassOf obo:VO_0012356, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1311
    ] .

obo:VO_0004201
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "J5dLPS/OMP" ;
    rdfs:seeAlso "violinID: 1118" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_263
    ] .

obo:VO_0004202
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C. muridarum Tarp subunit vaccine" ;
    rdfs:seeAlso "violinID: 1119" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83560
    ] .

obo:VO_0004203
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C. jejuni PorA protein vaccine" ;
    rdfs:seeAlso "violinID: 1120" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197
    ] .

obo:VO_0004204
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum pfCelTos protein vaccine" ;
    rdfs:seeAlso "violinID: 1121" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004205
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/806594" ;
    obo:VO_0003198 806594 ;
    obo:VO_0003560 "acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Prefilled Syringe [Boostrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2364909", "RXAUI: 5027374", "TUI: T200" ;
    rdfs:label "BOOSTRIX vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003995 .

obo:VO_0004206
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Boostrix (Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 8 MCG / Bordetella pertussis pertactin vaccine, inactivated 2.5 MCG / Bordetella pertussis toxoid vaccine, inactivated 8 MCG / diphtheria toxoid vaccine, inactivated 2.5 UNT / tetanus toxoid vaccine, inactivated 5 UNT) per 0.5 ML Prefilled Syringe", "Boostrix Tdap (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed) 0.5 ML Prefilled Syringe" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300370" ;
    obo:VO_0003198 1300370 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.016 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.005 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.016 MG/ML / diphtheria toxoid vaccine, inactivated 5 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Prefilled Syringe [Boostrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2364910", "RXAUI: 5027662, 7253757, 4625540, 4625564", "TUI: T200" ;
    rdfs:label "BOOSTRIX vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0004205, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003997
    ] .

obo:VO_0004207
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300365" ;
    obo:VO_0003198 1300365 ;
    a owl:Class ;
    rdfs:comment "CUI: C3474172", "RXAUI: 4625526", "TUI: T200" ;
    rdfs:label "Bordetella pertussis pertactin vaccine, inactivated 0.005 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003199 .

obo:VO_0004208
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1368371" ;
    obo:VO_0003198 1368371 ;
    a owl:Class ;
    rdfs:comment "CUI: C3535682", "RXAUI: 5068281", "TUI: T116, T129, T121" ;
    rdfs:label "BACILLUS ANTHRACIS STRAIN V770-NP1-R ANTIGENS"@en ;
    rdfs:subClassOf obo:VO_0000919, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000014
    ] .

obo:VO_0004209
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ovine Ecthyma Live Virus Vaccine" ;
    rdfs:seeAlso "violinID: 2074" ;
    rdfs:subClassOf obo:VO_0001460, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10258
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000890 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004210
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ovine Ecthyma Live Virus Vaccine" ;
    rdfs:seeAlso "violinID: 2075" ;
    rdfs:subClassOf obo:VO_0001460, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10258
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000269 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004211
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "West Nile Virus DNA Vaccine (USDA: 1995.D0)" ;
    rdfs:seeAlso "violinID: 2149" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000701 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004212
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Canine Parainfluenza Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47A9.20)" ;
    rdfs:seeAlso "violinID: 2736; violinID: 2737" ;
    rdfs:subClassOf obo:VO_0001526, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_149595
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000204 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004213
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799961" ;
    obo:VO_0003198 1799961 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271790", "RXAUI: 8235199", "TUI: T200" ;
    rdfs:label "BACILLUS ANTHRACIS STRAIN V770-NP1-R ANTIGENS 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004208 .

obo:VO_0004214
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Erysipelothrix Rhusiopathiae-Haemophilus Parasuis Bacterin (USDA: 49V9.20)" ;
    rdfs:seeAlso "violinID: 2979; violinID: 2980; violinID: 2981" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_738
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004215
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1174360" ;
    obo:VO_0003198 1174360 ;
    a owl:Class ;
    rdfs:comment "CUI: C3228377", "RXAUI: 3830942", "TUI: T200" ;
    rdfs:label "Biothrax Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000014 .

obo:VO_0004216
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1799963" ;
    obo:VO_0003198 1799963 ;
    a owl:Class ;
    rdfs:comment "CUI: C4271638", "RXAUI: 8235201", "TUI: T200" ;
    rdfs:label "BACILLUS ANTHRACIS STRAIN V770-NP1-R ANTIGENS 0.1 MG/ML [Biothrax]"@en ;
    rdfs:subClassOf obo:VO_0000014, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004213
    ] .

obo:VO_0004217
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Haemophilus Parasuis Bacterin (USDA: 49Q9.20)" ;
    rdfs:seeAlso "violinID: 2982; violinID: 2983" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_738
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000901 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004218
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/832681" ;
    obo:VO_0003198 832681 ;
    obo:VO_0003560 "Anthrax Vaccine Adsorbed Injectable Suspension [Biothrax]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2608510", "RXAUI: 2943547", "TUI: T200" ;
    rdfs:label "Biothrax Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0004215 .

obo:VO_0004219
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine encoding MIC8" ;
    rdfs:seeAlso "violinID: 3038" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004220
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. aureus IsdB subunit vaccine (V710)" ;
    rdfs:seeAlso "violinID: 3039" ;
    rdfs:subClassOf obo:VO_0002502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0004221
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. multocida rOmpH Vaccine" ;
    rdfs:seeAlso "violinID: 3040" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0004222
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Inactivated PMV-3 Vaccine with Specol" ;
    rdfs:seeAlso "violinID: 3046" ;
    rdfs:subClassOf obo:VO_0001527, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_260963
    ] .

obo:VO_0004223
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis rPA Vaccine with Rehydragel HPA adjuvant" ;
    rdfs:seeAlso "violinID: 3047" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004224
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Rotavirus Chimeric VP6 protein Vaccine" ;
    rdfs:seeAlso "violinID: 3048" ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10912
    ] .

obo:VO_0004225
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BHV1 gD subunit vaccine" ;
    rdfs:seeAlso "violinID: 3050" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0004226
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BVDV Inactivated Vaccine" ;
    rdfs:seeAlso "violinID: 3051" ;
    rdfs:subClassOf obo:VO_0001501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11099
    ] .

obo:VO_0004227
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Cancer Vaccine using E7 protein of human papillomavirus 16 and Algammulin" ;
    rdfs:seeAlso "violinID: 3053" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004228
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Cancer Vaccine using E7 protein of human papillomavirus 16 and Quil-A" ;
    rdfs:seeAlso "violinID: 3054" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004229
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. maxima oocysts with Arlacel A vaccine" ;
    rdfs:seeAlso "violinID: 3056" ;
    rdfs:subClassOf obo:VO_0001125, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5804
    ] .

obo:VO_0004230
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Tetanus Toxoid with Calcium Phosphate" ;
    rdfs:seeAlso "violinID: 3057" ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1485
    ] .

obo:VO_0004231
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Tetanus Toxoid with Stearyl Tyrosine" ;
    rdfs:seeAlso "violinID: 3058" ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1485
    ] .

obo:VO_0004232
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "V3 VLPs with Gamma inulin adjuvant" ;
    rdfs:seeAlso "violinID: 3059" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004233
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "gp120 recominant with GMDP adjuvant" ;
    rdfs:seeAlso "violinID: 3061" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004234
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "gp120 recominant with MDP adjuvant" ;
    rdfs:seeAlso "violinID: 3062" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004235
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rHA with IL-1Beta adjuvant" ;
    rdfs:seeAlso "violinID: 3063" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004236
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rHA with IL-2 adjuvant" ;
    rdfs:seeAlso "violinID: 3064" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004237
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rHA with IL-7 adjuvant" ;
    rdfs:seeAlso "violinID: 3065" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004238
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "gp140, Gag and Tat Protein Vaccine with MF59" ;
    rdfs:seeAlso "violinID: 3067" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004239
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HBsAg Liposomal MTP-PE Vaccine" ;
    rdfs:seeAlso "violinID: 3068" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004240
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Synthetic OMP1 Vaccine" ;
    rdfs:seeAlso "violinID: 3069" ;
    rdfs:subClassOf obo:VO_0001207, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_813
    ] .

obo:VO_0004241
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. donovani Recombinant Ld-Gamma-GCS in NIV system Vaccine" ;
    rdfs:seeAlso "violinID: 3070" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004242
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Inactivated HIV-2 Vaccine with PMMA" ;
    rdfs:seeAlso "violinID: 3071" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004243
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum MSP4 with AFCo1 Adjuvant" ;
    rdfs:seeAlso "violinID: 3072" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004244
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Inactivated split Mem 71 Virus with SPT adjuvant" ;
    rdfs:seeAlso "violinID: 3073" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004245
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant Colorectal cancer antigen GA733 Vaccine" ;
    rdfs:seeAlso "violinID: 3074" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004246
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Anthrax vaccine adsorbed with Squalene adjuvant" ;
    rdfs:seeAlso "violinID: 3076" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004247
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Group A streptococcal recombinant fusion peptide Vaccine" ;
    rdfs:seeAlso "violinID: 3077" ;
    rdfs:subClassOf obo:VO_0002852, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0004248
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant NY-ESO-1 Protein vaccine adjuvanted with Imiquimod" ;
    rdfs:seeAlso "violinID: 3078" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004249
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Mutagrip Vaccine with P40 Adjuvant" ;
    rdfs:seeAlso "violinID: 3080" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004250
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "attenuated Listeria expressing cancer antigen vaccine" ;
    rdfs:seeAlso "violinID: 3081" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004251
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "recombinant S gene Hepatitis B Vaccine with rIFN-gamma" ;
    rdfs:seeAlso "violinID: 3082" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004252
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Y. pestis F1 antigen Vaccine with Flagellin" ;
    rdfs:seeAlso "violinID: 3083" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004253
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Inactivated H1N1(2009) Vaccine with AF03 adjuvant" ;
    rdfs:seeAlso "violinID: 3084" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004254
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant NY-ESO-1 ISCOMATRIX Vaccine" ;
    rdfs:seeAlso "violinID: 3085" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004255
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant PA with Poly(I:C) Adjuvant" ;
    rdfs:seeAlso "violinID: 3086" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004256
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant Tir Protein Vaccine" ;
    rdfs:seeAlso "violinID: 3087" ;
    rdfs:subClassOf obo:VO_0000041, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ] .

obo:VO_0004257
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C. muridarum PmpG-1, PmpE/F-2, and MOMP Proteins Vaccine" ;
    rdfs:seeAlso "violinID: 3089" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83560
    ] .

obo:VO_0004258
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Synthetic MUC1 Peptide Vaccine" ;
    rdfs:seeAlso "violinID: 3091" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004259
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV-2 DNA vaccine" ;
    rdfs:seeAlso "violinID: 3092" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004260
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis B surface antigen (HBsAg) with JVRS-1000" ;
    rdfs:seeAlso "violinID: 3093" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004261
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "live TC-83 VEE Vaccine with DHEA" ;
    rdfs:seeAlso "violinID: 3094" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004262
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. coli CS3 in PLGA microspheres" ;
    rdfs:seeAlso "violinID: 3095" ;
    rdfs:subClassOf obo:VO_0000041, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ] .

obo:VO_0004263
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MVA/IL-15/5Mtb vaccine" ;
    rdfs:seeAlso "violinID: 3096" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004264
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rgp120 HIV Vaccine with immunoliposomes" ;
    rdfs:seeAlso "violinID: 3097" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004265
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pneumococcal polysaccharide conjugate vaccine serotype 1 (PNC-1)" ;
    rdfs:seeAlso "violinID: 3098" ;
    rdfs:subClassOf obo:VO_0003284, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004266
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "LEISH-F1+MPL-SE vaccine" ;
    rdfs:seeAlso "violinID: 3099" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004267
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HSV glycoproteins subunit vaccine" ;
    rdfs:seeAlso "violinID: 3100" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004268
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV-1 gp120 with mCT E112K" ;
    rdfs:seeAlso "violinID: 3101" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004269
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum MSA-2 subunit vaccine" ;
    rdfs:seeAlso "violinID: 3103" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004270
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis PA protein Vaccine with TMDP" ;
    rdfs:seeAlso "violinID: 3104" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004271
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. yoelii TyCS-VLP Vaccine" ;
    rdfs:seeAlso "violinID: 3105" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004272
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pVAX-P1 DNA vaccine" ;
    rdfs:seeAlso "violinID: 3106" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004273
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "YopE(67-77) Protein Vaccine" ;
    rdfs:seeAlso "violinID: 3107" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004274
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV recombinant gp160 Protein Vaccine" ;
    rdfs:seeAlso "violinID: 3108" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004275
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "human apo B-100 peptide-2 protein vaccine" ;
    rdfs:seeAlso "violinID: 3110" ;
    rdfs:subClassOf obo:VO_0002793 .

obo:VO_0004276
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MDA-modified human apo B-100 peptide Vaccine" ;
    rdfs:seeAlso "violinID: 3111" ;
    rdfs:subClassOf obo:VO_0002793 .

obo:VO_0004277
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Brucella melitensis mucR mutant vaccine" ;
    rdfs:seeAlso "violinID: 3117" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004278
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Tick-borne Encephalitis Virus C protein mutant vaccine" ;
    rdfs:seeAlso "violinID: 3147" ;
    rdfs:subClassOf obo:VO_0012190, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11084
    ] .

obo:VO_0004279
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Mycobacterium tuberculosis mce-2 mutant vaccine" ;
    rdfs:seeAlso "violinID: 3207" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004280
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Aflunov" ;
    rdfs:seeAlso "violinID: 3285" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000971 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004281
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Fluad" ;
    rdfs:seeAlso "violinID: 3286" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000971 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004282
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Focetria" ;
    rdfs:seeAlso "violinID: 3287" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000971 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004283
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Brucella abortus S19 vjbR mutant vaccine" ;
    rdfs:seeAlso "violinID: 3288" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_235
    ] .

obo:VO_0004284
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "African Swine Fever Virus 9GL mutant vaccine" ;
    rdfs:seeAlso "violinID: 3289" ;
    rdfs:subClassOf obo:VO_0001211, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10497
    ] .

obo:VO_0004285
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant B. abortus CobB protein with CFA/IFA adjuvant" ;
    rdfs:seeAlso "violinID: 3292" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004286
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant B. abortus AsnC protein with CFA/IFA adjuvant" ;
    rdfs:seeAlso "violinID: 3293" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004287
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M2 mutant from Influenza A" ;
    rdfs:seeAlso "violinID: 3294" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004288
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Mycobacterium tuberculosis mce-3 mutant vaccine" ;
    rdfs:seeAlso "violinID: 3296" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004289
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein" ;
    rdfs:seeAlso "violinID: 3299" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0004290
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine BacPAKHA encoding EqfKY HA" ;
    rdfs:seeAlso "violinID: 3301" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004291
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine p188 encoding H7" ;
    rdfs:seeAlso "violinID: 3303" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004292
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pCMV/Hl encoding H1" ;
    rdfs:seeAlso "violinID: 3304" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004293
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pCMV/H7" ;
    rdfs:seeAlso "violinID: 3305" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004294
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pIRES/HA encoding HA" ;
    rdfs:seeAlso "violinID: 3306" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004295
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pIRES/NA expressing NA" ;
    rdfs:seeAlso "violinID: 3307" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004296
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pIRES/HA/IL-2 expressing HA" ;
    rdfs:seeAlso "violinID: 3308" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004297
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pIRES/NA/IL-2 encoding NA" ;
    rdfs:seeAlso "violinID: 3309" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004298
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pIRES/HA/GM-CSF encoding HA" ;
    rdfs:seeAlso "violinID: 3310" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004299
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pIRES/NA/GM-CSF encoding NA" ;
    rdfs:seeAlso "violinID: 3311" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004300
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pIRES/HA/IL-12p35 + pIRES/NA/IL-12p40" ;
    rdfs:seeAlso "violinID: 3312" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004301
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pRSV-NP encoding the coding sequence from influenza virus A/PR/8/34." ;
    rdfs:seeAlso "violinID: 3316" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004302
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pHA/NP147Ã¢â‚¬â€œ155 encoding NP147-155" ;
    rdfs:seeAlso "violinID: 3318" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004303
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pBK-SFV-NP" ;
    rdfs:seeAlso "violinID: 3320" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004304
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pBK-SFV-HA" ;
    rdfs:seeAlso "violinID: 3322" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004305
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine HA-DNA" ;
    rdfs:seeAlso "violinID: 3324" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004306
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine d1TTFC-NP encoding NP" ;
    rdfs:seeAlso "violinID: 3327" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004307
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine A/NP" ;
    rdfs:seeAlso "violinID: 3330" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004308
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine NP DNA" ;
    rdfs:seeAlso "violinID: 3331" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004309
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine HA DNA" ;
    rdfs:seeAlso "violinID: 3332" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004310
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine NA-DNA" ;
    rdfs:seeAlso "violinID: 3333" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004311
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine H5 DNA" ;
    rdfs:seeAlso "violinID: 3338" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004312
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine pSAG1-ROP2-SAG2" ;
    rdfs:seeAlso "violinID: 3342" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004313
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2" ;
    rdfs:seeAlso "violinID: 3343" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004314
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Y. pestis DNA vaccine F1-V DNA" ;
    rdfs:seeAlso "violinID: 3344" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004315
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 DNA vaccine pRSVgIV" ;
    rdfs:seeAlso "violinID: 3349" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0004316
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 recombinant vector vaccine BHVl/BRSVG" ;
    rdfs:seeAlso "violinID: 3350" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0004317
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB" ;
    rdfs:seeAlso "violinID: 3357" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0004318
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDFL encoding gD" ;
    rdfs:seeAlso "violinID: 3359" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0004319
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDF encoding gD" ;
    rdfs:seeAlso "violinID: 3360" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10320
    ] .

obo:VO_0004320
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Foot and mouth disease DNA vaccine pWRMHX encoding a minimal self-cleaving ribozyme" ;
    rdfs:seeAlso "violinID: 3366" ;
    rdfs:subClassOf obo:VO_0001213, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12110
    ] .

obo:VO_0004321
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IHNV DNA vaccine pCMV4-G" ;
    rdfs:seeAlso "violinID: 3369" ;
    rdfs:subClassOf obo:VO_0012165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11290
    ] .

obo:VO_0004322
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IHNV DNA vaccine pCMV4-N encoding the nucleoprotein" ;
    rdfs:seeAlso "violinID: 3370" ;
    rdfs:subClassOf obo:VO_0012165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11290
    ] .

obo:VO_0004323
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Murine cytomegalovirus DNA vaccine pcDNA-89 encoding pp89" ;
    rdfs:seeAlso "violinID: 3372" ;
    rdfs:subClassOf obo:VO_0003062, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10366
    ] .

obo:VO_0004324
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Newcastle disease virus DNA vaccine pCAGF encoding the F protein" ;
    rdfs:seeAlso "violinID: 3373" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11176
    ] .

obo:VO_0004325
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PRRSV DNA vaccine GST-ORF5 encoding GP5" ;
    rdfs:seeAlso "violinID: 3374" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0004326
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Rabies virus DNA vaccine pSG5rab.gp" ;
    rdfs:seeAlso "violinID: 3375" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004327
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Lymphocytic choriomeningitis virus DNA vaccine pCMV-NP" ;
    rdfs:seeAlso "violinID: 3376" ;
    rdfs:subClassOf obo:VO_0003044, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11623
    ] .

obo:VO_0004328
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine VlJns-Ll encoding L1" ;
    rdfs:seeAlso "violinID: 3379" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004329
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine Pe7(pcDNA3-Sig/sE7/LAMP) encoding E7" ;
    rdfs:seeAlso "violinID: 3380" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004330
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine pC16-L1 encoding L1" ;
    rdfs:seeAlso "violinID: 3383" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004331
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine CRT/E7 DNA" ;
    rdfs:seeAlso "violinID: 3384" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004332
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine E7IR" ;
    rdfs:seeAlso "violinID: 3388" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004333
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine E7SH DNA" ;
    rdfs:seeAlso "violinID: 3389" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004334
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus DNA vaccine GP DNA" ;
    rdfs:seeAlso "violinID: 3392" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004335
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant rAD-GP encoding GP" ;
    rdfs:seeAlso "violinID: 3393" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004336
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant VSVdeltaG-GP encoding GP" ;
    rdfs:seeAlso "violinID: 3394" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004337
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant vector vaccine EBO7 encoding GP from SEBOV and ZEBOV" ;
    rdfs:seeAlso "violinID: 3395" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004338
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VHSV DNA vaccine pCMV-vhsG encoding glycoprotein G" ;
    rdfs:seeAlso "violinID: 3396" ;
    rdfs:subClassOf obo:VO_0001224, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11287
    ] .

obo:VO_0004339
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VHSV DNA vaccine pCMV-vhsN encoding nucleocapsid protein N and glycoprotein G" ;
    rdfs:seeAlso "violinID: 3397" ;
    rdfs:subClassOf obo:VO_0001224, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11287
    ] .

obo:VO_0004340
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Classical swine fever virus DNA vaccine pCI-gp55" ;
    rdfs:seeAlso "violinID: 3398" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0004341
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human cytomegalovirus DNA vaccine VCL-CB01 encoding phosphoprotein 65 and gB" ;
    rdfs:seeAlso "violinID: 3401" ;
    rdfs:subClassOf obo:VO_0001227, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10359
    ] .

obo:VO_0004342
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV DNA vaccine Ad26/Ad5HVR48 encoding HIV or SIV env or gag" ;
    rdfs:seeAlso "violinID: 3426" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004343
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SIV DNA vaccine pVacc4 encoding env from mac239" ;
    rdfs:seeAlso "violinID: 3430" ;
    rdfs:subClassOf obo:VO_0000751, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11723
    ] .

obo:VO_0004344
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV DNA vaccine SHIV-89.6 DNA (DNA/89.6)" ;
    rdfs:seeAlso "violinID: 3439" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004345
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV DNA vaccine pCMN160" ;
    rdfs:seeAlso "violinID: 3449" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004346
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SIV DNA vaccine pSIVgag and pmacIL-15 encoding SIV core protein" ;
    rdfs:seeAlso "violinID: 3468" ;
    rdfs:subClassOf obo:VO_0000751, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11723
    ] .

obo:VO_0004347
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV recombinant vector vaccine MVA-gag encoding gag" ;
    rdfs:seeAlso "violinID: 3478" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004348
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV DNA vaccine pHIS-SHIV-B" ;
    rdfs:seeAlso "violinID: 3481" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004349
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV DNA vaccine SIVmac239 Gag-Pol-Nef and mock Env with rAd5 boost" ;
    rdfs:seeAlso "violinID: 3485" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004350
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV recombinant vector vaccine MVA.HIVA encoding env and rev" ;
    rdfs:seeAlso "violinID: 3491" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004351
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HIV DNA vaccine VlJns-tPA-gp120" ;
    rdfs:seeAlso "violinID: 3497" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004352
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis B DNA vaccine PLGA-CTAB-DNA encoding the small envelope gene" ;
    rdfs:seeAlso "violinID: 3510" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004353
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Duck hepatitis B DNA vaccine pcDNA I-S encoding small S proteins" ;
    rdfs:seeAlso "violinID: 3516" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004354
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis B DNA vaccine pRc/CMV-HBs(S) encoding HBsAg" ;
    rdfs:seeAlso "violinID: 3519" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004355
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pDNA encoding M2 and NP" ;
    rdfs:seeAlso "violinID: 3520" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004356
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA vaccine pcDNA3.1+/Ag85A DNA encoding Ag85A" ;
    rdfs:seeAlso "violinID: 3522" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004357
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis B DNA vaccine pS encoding major envelope proteins" ;
    rdfs:seeAlso "violinID: 3524" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004358
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis B DNA vaccine pCMV-HBs encoding HBsAg" ;
    rdfs:seeAlso "violinID: 3525" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004359
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis B DNA vaccine pCEA/HBsAg encoding CEA and HBsAg" ;
    rdfs:seeAlso "violinID: 3528" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004360
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis B DNA vaccine pCMV-S2.S encoding the HBV(ayw Strain) envelope protein." ;
    rdfs:seeAlso "violinID: 3533" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10407
    ] .

obo:VO_0004361
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Coxsackievirus DNA vaccine pCMV/VPl encoding VP1" ;
    rdfs:seeAlso "violinID: 3538" ;
    rdfs:subClassOf obo:VO_0001228, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12066
    ] .

obo:VO_0004362
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83" ;
    rdfs:seeAlso "violinID: 3540" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004363
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs)" ;
    rdfs:seeAlso "violinID: 3546" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004364
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA vaccine DNAAg85A encoding a single immunogenic M.tb Ag" ;
    rdfs:seeAlso "violinID: 3547" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004365
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine gD-2 encoding gD" ;
    rdfs:seeAlso "violinID: 3548" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004366
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine Delta-gB-2 encoding gB" ;
    rdfs:seeAlso "violinID: 3549" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004367
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine ICP-27 DNA encoding ICP-27" ;
    rdfs:seeAlso "violinID: 3550" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004368
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine gB-DNA encoding gB" ;
    rdfs:seeAlso "violinID: 3551" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004369
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine gBDNA encoding gB" ;
    rdfs:seeAlso "violinID: 3552" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004370
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine encoding gD and gB from HSV-2 strain Curtis" ;
    rdfs:seeAlso "violinID: 3553" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004371
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Rabies virus DNA vaccine pCMV-intA-rabies encoding glycoprotein G" ;
    rdfs:seeAlso "violinID: 3555" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004372
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Rabies virus DNA vaccine encoding the ERA glycoprotein" ;
    rdfs:seeAlso "violinID: 3556" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004373
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Leishmania major DNA vaccine KMP-11" ;
    rdfs:seeAlso "violinID: 3557" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004374
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine encoding TSA-1, ASP-1, ASP-2" ;
    rdfs:seeAlso "violinID: 3558" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5693
    ] .

obo:VO_0004375
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine encoding ASP-2" ;
    rdfs:seeAlso "violinID: 3559" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5693
    ] .

obo:VO_0004376
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine pUB-ASP-2" ;
    rdfs:seeAlso "violinID: 3560" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5693
    ] .

obo:VO_0004377
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine pTS encoding T. cruzi antigens" ;
    rdfs:seeAlso "violinID: 3561" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5693
    ] .

obo:VO_0004378
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Lassa fever virus recombinant vector vaccine V-LSG encoding the glycoprotein" ;
    rdfs:seeAlso "violinID: 3565" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004379
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Lassa fever virus recombinant vector vaccine V-LSG/N encoding the glycoprotein and the nucleoprotein" ;
    rdfs:seeAlso "violinID: 3567" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004380
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Lassa fever virus recombinant vector vaccine YFV17D/LASV-GPC encoding the glycoprotein precursor" ;
    rdfs:seeAlso "violinID: 3570" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0004381
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant vector vaccine pVSVXN2-Delta-G/ZEBOVsGP encoding GP" ;
    rdfs:seeAlso "violinID: 3574" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004382
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant adenovirus vaccine AdC7-ZGP encoding GP" ;
    rdfs:seeAlso "violinID: 3579" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004383
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant vector vaccine Ad-CMVZGP encoding the glycoprotein" ;
    rdfs:seeAlso "violinID: 3580" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004384
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus recombinant vector vaccine Ad-CAGoptZGP encoding the envelope glycoprotein" ;
    rdfs:seeAlso "violinID: 3581" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004385
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ebola virus DNA vaccine DNA/rAd5 encoding ZEBOV and SEBOV antigens" ;
    rdfs:seeAlso "violinID: 3591" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004386
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine PA" ;
    rdfs:seeAlso "violinID: 3593" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004387
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus DNA vaccine MARV GP encoding GP" ;
    rdfs:seeAlso "violinID: 3594" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004388
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus recombinant vector vaccine CAdVax-Panfilo" ;
    rdfs:seeAlso "violinID: 3596" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004389
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus DNA prime/boost vaccine DNA/rAd5-GP encoding GP from strain Angola" ;
    rdfs:seeAlso "violinID: 3598" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004390
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus DNA vaccine DNA-GP encoding GP" ;
    rdfs:seeAlso "violinID: 3599" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004391
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus recombinant vector vaccine MBGV GP" ;
    rdfs:seeAlso "violinID: 3600" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004392
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. abortus DNA vaccine pcDNA3.1-p39-L7/L12 encoding p39-L7/L12 fusion protein" ;
    rdfs:seeAlso "violinID: 3605" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004393
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. abortus DNA vaccine pcDNA3-SOD encoding Cu-Zn SOD" ;
    rdfs:seeAlso "violinID: 3607" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004394
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis DNA vaccine pCI-Omp31" ;
    rdfs:seeAlso "violinID: 3611" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004395
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis DNA vaccine pCIBLSOmp31 encoding BLSOmp31 (fusion protein)" ;
    rdfs:seeAlso "violinID: 3613" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004396
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis DNA vaccine p-Omp25" ;
    rdfs:seeAlso "violinID: 3615" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004397
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. melitensis DNA vaccine p-ialB" ;
    rdfs:seeAlso "violinID: 3616" ;
    rdfs:subClassOf obo:VO_0000709, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004398
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Lymphoma DNA vaccine V-Alpha-V-Beta-V-Beta-FrC" ;
    rdfs:seeAlso "violinID: 3617" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004399
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. falciparum recombinant vector vaccine MVA.ME-TRAP" ;
    rdfs:seeAlso "violinID: 3628" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004400
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Glypican-3-derived peptide vaccine for human hepatocellular carcinoma" ;
    rdfs:seeAlso "violinID: 3643" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004401
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "EAE DNA vaccine pZZ/MBP68-85 encoding MBP" ;
    rdfs:seeAlso "violinID: 3647" ;
    rdfs:subClassOf obo:VO_0002837 .

obo:VO_0004402
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "EAU DNA vaccine IRBP-DNA encoding IRBP" ;
    rdfs:seeAlso "violinID: 3649" ;
    rdfs:subClassOf obo:VO_0002837 .

obo:VO_0004403
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Autoimmune diabetes DNA vaccine pND2-SGAD55" ;
    rdfs:seeAlso "violinID: 3652" ;
    rdfs:subClassOf obo:VO_0002811 .

obo:VO_0004404
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Autoimmune diabetes DNA vaccine pCMV-1/rGAD65 encoding GAD" ;
    rdfs:seeAlso "violinID: 3653" ;
    rdfs:subClassOf obo:VO_0002811 .

obo:VO_0004405
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Autoimmune diabetes DNA vaccine pND2-GAD65-BAX encoding GAD and BAX" ;
    rdfs:seeAlso "violinID: 3655" ;
    rdfs:subClassOf obo:VO_0002811 .

obo:VO_0004406
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Insulin-dependent diabetes mellitus DNA vaccine JwGAD65 + IL-4" ;
    rdfs:seeAlso "violinID: 3656" ;
    rdfs:subClassOf obo:VO_0002811 .

obo:VO_0004407
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Adjuvant arthritis DNA vaccine pCMV3.65 encoding HSP65" ;
    rdfs:seeAlso "violinID: 3661" ;
    rdfs:subClassOf obo:VO_0002823 .

obo:VO_0004408
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Pristane-induced arthritis DNA vaccine DNA-hsp65 encoding Mycobacterium leprae 65-kDa heat shock protein" ;
    rdfs:seeAlso "violinID: 3662" ;
    rdfs:subClassOf obo:VO_0002823 .

obo:VO_0004409
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Adjuvant arthritis DNA vaccine CII encoding type II collagen" ;
    rdfs:seeAlso "violinID: 3663" ;
    rdfs:subClassOf obo:VO_0002823 .

obo:VO_0004410
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Adjuvant arthritis DNA vaccine pcDNA-CCOL2A1 encoding type II collagen" ;
    rdfs:seeAlso "violinID: 3664" ;
    rdfs:subClassOf obo:VO_0002823 .

obo:VO_0004411
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine pSIN-gB encoding gB" ;
    rdfs:seeAlso "violinID: 3665" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004412
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus DNA vaccine pCI-gB encoding gB" ;
    rdfs:seeAlso "violinID: 3666" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004413
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. burgdorferi DNA vaccine pCMV-ZS7/TPA encoding OspC from Borrelia burgdorferi sensu lato" ;
    rdfs:seeAlso "violinID: 3669" ;
    rdfs:subClassOf obo:VO_0000764, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0004414
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C. tetani DNA vaccine pcDNA3tetC encoding fragment C" ;
    rdfs:seeAlso "violinID: 3672" ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1485
    ] .

obo:VO_0004415
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "West Nile virus DNA vaccine pCBWN encoding prM and E" ;
    rdfs:seeAlso "violinID: 3673" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0004416
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine pDNA encoding PA" ;
    rdfs:seeAlso "violinID: 3677" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004417
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine LF pDNA encoding LF" ;
    rdfs:seeAlso "violinID: 3678" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004418
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. acervulina DNA vaccine 3-1E" ;
    rdfs:seeAlso "violinID: 3681" ;
    rdfs:subClassOf obo:VO_0001459, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5800
    ] .

obo:VO_0004419
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. rhabdovirus DNA vaccine pHRV-G encoding HIRRV and VHSV G proteins" ;
    rdfs:seeAlso "violinID: 3682" ;
    rdfs:subClassOf obo:VO_0002455, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38142
    ] .

obo:VO_0004420
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IHNV DNA vaccine pCDNA-G encoding G" ;
    rdfs:seeAlso "violinID: 3687" ;
    rdfs:subClassOf obo:VO_0012165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11290
    ] .

obo:VO_0004421
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VEE virus DNA vaccine VEEV IA/B parent encoding structural genes" ;
    rdfs:seeAlso "violinID: 3689" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004422
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VEE virus recombinant vector vaccine RAd/VEEV" ;
    rdfs:seeAlso "violinID: 3690" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004423
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VEE virus recombinant vector vaccine RAd/VEEV#2" ;
    rdfs:seeAlso "violinID: 3691" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004424
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VEE virus recombinant vector vaccine RAd/VEEV#3 encoding TC-83" ;
    rdfs:seeAlso "violinID: 3692" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004425
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Cancer DNA vaccine p.DOM-AH1 encoding fragment C" ;
    rdfs:seeAlso "violinID: 3695" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004426
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Carcinoma DNA vaccine pVAX/E2A" ;
    rdfs:seeAlso "violinID: 3696" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004427
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B-cell lymphoma DNA vaccine VCL-1642.XXX encoding a chimeric immunoglobulin molecule onsisting of tumor-specific variable (Id) regions" ;
    rdfs:seeAlso "violinID: 3698" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004428
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Colorectal cancer DNA vaccine pCEA/HBsAg encoding carcinoembryonic antigen and hepatitis B surface antigen" ;
    rdfs:seeAlso "violinID: 3699" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004429
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B16 melanoma DNA vaccine pSin-hTRP-1 encoding TRP-1" ;
    rdfs:seeAlso "violinID: 3700" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004430
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B16 melanoma DNA vaccine pCMV-hTRP-1 encoding TRP-1" ;
    rdfs:seeAlso "violinID: 3701" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004431
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine TA2M encoding tyrosinase peptides" ;
    rdfs:seeAlso "violinID: 3705" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004432
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine VR-S8/VR-IL2/AD-S8 encoding survivin" ;
    rdfs:seeAlso "violinID: 3713" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004433
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine pCR3.1-VS-HSP65-TP-GRP6-M2 encoding 6 tandem repeats of GRP" ;
    rdfs:seeAlso "violinID: 3717" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004434
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine pNL3-MAGE-1-GM" ;
    rdfs:seeAlso "violinID: 3718" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004435
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine pN4a-MAGE-1-GM" ;
    rdfs:seeAlso "violinID: 3719" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004436
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine SINCp c-muMUC18 encoding MCAM/MUC18" ;
    rdfs:seeAlso "violinID: 3720" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004437
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Lung metastasis DNA vaccine pCEP4-MUC1 encoding MUC1" ;
    rdfs:seeAlso "violinID: 3723" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004438
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine hugp100 encoding gp100" ;
    rdfs:seeAlso "violinID: 3724" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004439
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine VR1012/mPmel17" ;
    rdfs:seeAlso "violinID: 3726" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004440
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine gp75 DNA encoding melanosomal membrane glycoproteins, gp75" ;
    rdfs:seeAlso "violinID: 3727" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004441
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma recombinant vector vaccine rVVmTRP-1 encoding TRP-1" ;
    rdfs:seeAlso "violinID: 3728" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004442
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine hTRP2 encoding TRP-2" ;
    rdfs:seeAlso "violinID: 3729" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004443
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine pUB-TRP-2 encoding a fusion protein linking murine ubiquitin (UB) to the N-terminus of the full-length mTRP-2" ;
    rdfs:seeAlso "violinID: 3730" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004444
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Neuroblastoma DNA vaccine HuDsec" ;
    rdfs:seeAlso "violinID: 3731" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004445
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine pcDNA3-STEAP encoding six-transmembrane epithelial antigen" ;
    rdfs:seeAlso "violinID: 3736" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004446
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine hPSMAt encoding PSMA" ;
    rdfs:seeAlso "violinID: 3737" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004447
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine rPSMAt encoding PSMA" ;
    rdfs:seeAlso "violinID: 3738" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004448
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine pVax-PSA" ;
    rdfs:seeAlso "violinID: 3740" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004449
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine psig-3P-Fc encoding 3P(hPSM, hPAP, or hPSA)-Fc fusion protein" ;
    rdfs:seeAlso "violinID: 3742" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004450
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine PSCA-HSP encoding PSCA and HSP" ;
    rdfs:seeAlso "violinID: 3744" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004451
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine encoding PSCA" ;
    rdfs:seeAlso "violinID: 3745" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004452
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Prostate cancer DNA vaccine pmPSCA encoding PSCA" ;
    rdfs:seeAlso "violinID: 3746" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004453
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain)" ;
    rdfs:seeAlso "violinID: 3754" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004454
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine pVR1020-GRA1" ;
    rdfs:seeAlso "violinID: 3755" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004455
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine T.g.HSP70" ;
    rdfs:seeAlso "violinID: 3756" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004456
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chinese S. japonicum DNA vaccine pCMV-Sjc97 encoding paramyosin" ;
    rdfs:seeAlso "violinID: 3757" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004457
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chinese S. japonicum DNA vaccine pVAX/SjFABP encoding FABP" ;
    rdfs:seeAlso "violinID: 3758" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004458
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chinese S. japonicum DNA vaccine SjCTPI" ;
    rdfs:seeAlso "violinID: 3760" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004459
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chinese S. japonicum DNA vaccine SjCTPI-Hsp70" ;
    rdfs:seeAlso "violinID: 3761" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004460
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chinese S. japonicum DNA vaccine pVIVO2-IL12-Sj23 encoding Sj23 and IL-12" ;
    rdfs:seeAlso "violinID: 3762" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004461
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. mansoni DNA vaccine Sm23-pcDNA encoding Sm23" ;
    rdfs:seeAlso "violinID: 3763" ;
    rdfs:subClassOf obo:VO_0003046, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6183
    ] .

obo:VO_0004462
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. mansoni DNA vaccine pcDNA/CTSOD encoding SOD" ;
    rdfs:seeAlso "violinID: 3764" ;
    rdfs:subClassOf obo:VO_0003046, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6183
    ] .

obo:VO_0004463
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. mansoni DNA vaccine pcDNA/GPXbb encoding glutathione-S-peroxidase, GPX" ;
    rdfs:seeAlso "violinID: 3765" ;
    rdfs:subClassOf obo:VO_0003046, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6183
    ] .

obo:VO_0004464
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. mansoni DNA vaccine Sm-p80-pcDNA3 encoding the large subunit of S. mansoni calpain" ;
    rdfs:seeAlso "violinID: 3767" ;
    rdfs:subClassOf obo:VO_0003046, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6183
    ] .

obo:VO_0004465
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Melanoma DNA vaccine xenogeneic DNA encoding murine tyrosinase" ;
    rdfs:seeAlso "violinID: 3768" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004466
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine sA encoding prM and E from Dengue Virus 4" ;
    rdfs:seeAlso "violinID: 3770" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004467
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine sB encoding E" ;
    rdfs:seeAlso "violinID: 3771" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004468
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine sC encoding prM and E" ;
    rdfs:seeAlso "violinID: 3772" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004469
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine sABC encoding prM and E" ;
    rdfs:seeAlso "violinID: 3773" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004470
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine D1ME encoding prM and E" ;
    rdfs:seeAlso "violinID: 3778" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004471
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine pE1D2 encoding E from Dengue Virus 2 strain New Guinea C" ;
    rdfs:seeAlso "violinID: 3779" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004472
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine pcTPANS1 encoding NS1 fused to the tissue plasminogen activator signal sequence" ;
    rdfs:seeAlso "violinID: 3781" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004473
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine 1040D2MEL encoding dengue-2 prM-E-LAMP chimeric protein" ;
    rdfs:seeAlso "violinID: 3783" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004474
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue virus DNA vaccine p1012D2ME encoding prM and E from DEN 2 New Guinea C strain" ;
    rdfs:seeAlso "violinID: 3784" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004475
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2" ;
    rdfs:seeAlso "violinID: 3785" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004476
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine pTPA-PA63" ;
    rdfs:seeAlso "violinID: 3792" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004477
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine pLAMP1-PA63" ;
    rdfs:seeAlso "violinID: 3793" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004478
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine pTPA-P" ;
    rdfs:seeAlso "violinID: 3795" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004479
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine pIMS-120 encoding PA" ;
    rdfs:seeAlso "violinID: 3796" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004480
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine pCPA" ;
    rdfs:seeAlso "violinID: 3801" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004481
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA vaccine PA83 furin" ;
    rdfs:seeAlso "violinID: 3802" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004482
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Vaccinia virus DNA vaccine A33R from strain IHD-J" ;
    rdfs:seeAlso "violinID: 3805" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10245
    ] .

obo:VO_0004483
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Vaccinia virus DNA vaccine B5R" ;
    rdfs:seeAlso "violinID: 3808" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10245
    ] .

obo:VO_0004484
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Vaccinia virus DNA vaccine pWRG/L1R" ;
    rdfs:seeAlso "violinID: 3810" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10245
    ] .

obo:VO_0004485
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Vaccinia virus DNA vaccine 4pox" ;
    rdfs:seeAlso "violinID: 3814" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10245
    ] .

obo:VO_0004486
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Vaccinia virus DNA vaccine wtD8L" ;
    rdfs:seeAlso "violinID: 3815" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10245
    ] .

obo:VO_0004487
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Vaccinia virus DNA vaccine tPA-D8L" ;
    rdfs:seeAlso "violinID: 3816" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10245
    ] .

obo:VO_0004488
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VEE virus DNA vaccine encoding 26S" ;
    rdfs:seeAlso "violinID: 3822" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004489
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "WEE virus DNA vaccine pVHX-6 encoding 26S" ;
    rdfs:seeAlso "violinID: 3823" ;
    rdfs:subClassOf obo:VO_0012188, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11039
    ] .

obo:VO_0004490
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VEE virus DNA vaccine pSTU-TRDF encoding VEEV E3-E2-6K" ;
    rdfs:seeAlso "violinID: 3829" ;
    rdfs:subClassOf obo:VO_0001499, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11036
    ] .

obo:VO_0004491
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Sindbis virus DNA vaccine encoding E2" ;
    rdfs:seeAlso "violinID: 3830" ;
    rdfs:subClassOf obo:VO_0003043, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11034
    ] .

obo:VO_0004492
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "FeLV DNA vaccine gag/pol and env" ;
    rdfs:seeAlso "violinID: 3831" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11768
    ] .

obo:VO_0004493
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IPNV DNA vaccine pEGFP-N1-SegA and pEGFP-N1-VP2" ;
    rdfs:seeAlso "violinID: 3834" ;
    rdfs:subClassOf obo:VO_0003055, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11002
    ] .

obo:VO_0004494
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VHSV DNA vaccine pVHS-G encoding glycoproteins" ;
    rdfs:seeAlso "violinID: 3836" ;
    rdfs:subClassOf obo:VO_0003056, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11287
    ] .

obo:VO_0004495
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IHNV DNA vaccine pIHN-G encoding glycoproteins" ;
    rdfs:seeAlso "violinID: 3837" ;
    rdfs:subClassOf obo:VO_0012165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11290
    ] .

obo:VO_0004496
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. marinum pCMV-85A" ;
    rdfs:seeAlso "violinID: 3838" ;
    rdfs:subClassOf obo:VO_0003058, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1781
    ] .

obo:VO_0004497
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Avian influenza virus DNA vaccine pH5HA" ;
    rdfs:seeAlso "violinID: 3839" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004498
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Avian influenza virus DNA vaccine pN1NA encoding N1 neuraminidase" ;
    rdfs:seeAlso "violinID: 3840" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004499
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Avian influenza virus DNA vaccine pNP" ;
    rdfs:seeAlso "violinID: 3841" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004500
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pCMVH5HA" ;
    rdfs:seeAlso "violinID: 3842" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004501
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine p-Beta-actinH7HA" ;
    rdfs:seeAlso "violinID: 3844" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004502
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pCAGGoptiHA" ;
    rdfs:seeAlso "violinID: 3845" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004503
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine pCAGGHA" ;
    rdfs:seeAlso "violinID: 3846" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004504
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Avian influenza DNA vaccine pCMV-M" ;
    rdfs:seeAlso "violinID: 3847" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004505
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Avian influenza virus DNA vaccine pCMV-HA" ;
    rdfs:seeAlso "violinID: 3848" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004506
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PRRSV DNA vaccine pCA-U-optiGP5" ;
    rdfs:seeAlso "violinID: 3849" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0004507
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PRRSV DNA vaccine pIRESorf5/IFN-Gamma" ;
    rdfs:seeAlso "violinID: 3852" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0004508
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PRRSV DNA vaccine pIRESorf5/IL-2" ;
    rdfs:seeAlso "violinID: 3853" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0004509
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PRRSV DNA vaccine pIRESorf7/IL-2" ;
    rdfs:seeAlso "violinID: 3854" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0004510
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PRRSV DNA vaccine pCI-ORF5/ORF6" ;
    rdfs:seeAlso "violinID: 3857" ;
    rdfs:subClassOf obo:VO_0001802, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28344
    ] .

obo:VO_0004511
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chinese S. japonicum DNA vaccine SjC23-Hsp70" ;
    rdfs:seeAlso "violinID: 3860" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004512
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Chinese S. japonicum DNA vaccine SjC23" ;
    rdfs:seeAlso "violinID: 3861" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004513
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. burgdorferi DNA vaccine encoding strain B31 OspA" ;
    rdfs:seeAlso "violinID: 3863" ;
    rdfs:subClassOf obo:VO_0000764, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_139
    ] .

obo:VO_0004514
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine expressing the E2 protein" ;
    rdfs:seeAlso "violinID: 3864" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0004515
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pCgap DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase" ;
    rdfs:seeAlso "violinID: 3865" ;
    rdfs:subClassOf obo:VO_0000611, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_738
    ] .

obo:VO_0004516
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "DNA vaccine expressing PspA" ;
    rdfs:seeAlso "violinID: 3867" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004517
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PsaA DNA Vaccine" ;
    rdfs:seeAlso "violinID: 3868" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004518
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B16 melanoma DNA vaccine pSin-mTRP-1" ;
    rdfs:seeAlso "violinID: 3869" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004519
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes Simplex Virus Type 1 DNA Vaccine pRSC-gD-IL-21" ;
    rdfs:seeAlso "violinID: 3870" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004520
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes Simplex Virus Type 1 DNA Vaccine encoding 5gP" ;
    rdfs:seeAlso "violinID: 3871" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004521
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes Simplex Virus 2 DNA Vaccine Vaxfectin-gD2" ;
    rdfs:seeAlso "violinID: 3872" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004522
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes Simplex Virus 2 DNA Vaccine encoding gD" ;
    rdfs:seeAlso "violinID: 3873" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004523
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Herpes Simplex Virus 2 DNA Vaccine encoding gD with CD40L" ;
    rdfs:seeAlso "violinID: 3874" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004524
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Classical Swine Fever Virus DNA Vaccine pcDNA/E2 with TRIF" ;
    rdfs:seeAlso "violinID: 3876" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0004525
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Avian pneumovirus DNA Vaccine expressing the F gene" ;
    rdfs:seeAlso "violinID: 3878" ;
    rdfs:subClassOf obo:VO_0001514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38525
    ] .

obo:VO_0004526
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Murine cytomegalovirus DNA vaccine pgM-pgN" ;
    rdfs:seeAlso "violinID: 3880" ;
    rdfs:subClassOf obo:VO_0003062, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10366
    ] .

obo:VO_0004527
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. maxima DNA vaccine pcDNA-Gam56" ;
    rdfs:seeAlso "violinID: 3881" ;
    rdfs:subClassOf obo:VO_0001125, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5804
    ] .

obo:VO_0004528
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine pVAX-TgMIC13" ;
    rdfs:seeAlso "violinID: 3882" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004529
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hepatitis D DNA vaccine pcDNA3p27/Ad5F35p27" ;
    rdfs:seeAlso "violinID: 3883" ;
    rdfs:subClassOf obo:VO_0003059, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12475
    ] .

obo:VO_0004530
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. major DNA vaccine pcLACK + IL-22" ;
    rdfs:seeAlso "violinID: 3884" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004531
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine ROP8-pVAX-1" ;
    rdfs:seeAlso "violinID: 3885" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004532
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. cruzi DNA vaccine encoding TSA-1 and Tc24" ;
    rdfs:seeAlso "violinID: 3886" ;
    rdfs:subClassOf obo:VO_0001385, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5693
    ] .

obo:VO_0004533
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IBDV DNA vaccine pCAGoptiVP2/rVP2" ;
    rdfs:seeAlso "violinID: 3887" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004534
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IBDV DNA vaccine pCAGVP243-IL-18" ;
    rdfs:seeAlso "violinID: 3888" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004535
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IBV DNA vaccine pVAX1-16S1/M/N" ;
    rdfs:seeAlso "violinID: 3889" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ] .

obo:VO_0004536
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. multocida DNA vaccine pcDNA-OMPH + pcDNA-OMPA" ;
    rdfs:seeAlso "violinID: 3890" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0004537
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. multocida DNA vaccine pcDNA-OMPH/OMPA" ;
    rdfs:seeAlso "violinID: 3891" ;
    rdfs:subClassOf obo:VO_0000620, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_747
    ] .

obo:VO_0004538
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BVDV DNA vaccine encoding E2" ;
    rdfs:seeAlso "violinID: 3892" ;
    rdfs:subClassOf obo:VO_0003061, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_54315
    ] .

obo:VO_0004539
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. rhusiopathiae DNA vaccine pcD-ACSC" ;
    rdfs:seeAlso "violinID: 3893" ;
    rdfs:subClassOf obo:VO_0001456, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1648
    ] .

obo:VO_0004540
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. avium DNA vaccine DNA-Av35/p2AIL12" ;
    rdfs:seeAlso "violinID: 3894" ;
    rdfs:subClassOf obo:VO_0002501, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1764
    ] .

obo:VO_0004541
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. aureus DNA vaccine pClfaSrtD13" ;
    rdfs:seeAlso "violinID: 3895" ;
    rdfs:subClassOf obo:VO_0002502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0004542
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. aureus DNA vaccine encoding Efb, FnbpA, ClfA, Cna" ;
    rdfs:seeAlso "violinID: 3896" ;
    rdfs:subClassOf obo:VO_0002502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1280
    ] .

obo:VO_0004543
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. anthracis DNA Vaccine expressing PA" ;
    rdfs:seeAlso "violinID: 3897" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004544
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "A. pleuropneumoniae DNA vaccine pcDNA-apxIA/pcDNA-apxIIA" ;
    rdfs:seeAlso "violinID: 3898" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_715
    ] .

obo:VO_0004545
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. pertussis DNA vaccine pcDNA/S1" ;
    rdfs:seeAlso "violinID: 3899" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0004546
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "B. abortus DNA vaccine pVF278" ;
    rdfs:seeAlso "violinID: 3900" ;
    rdfs:subClassOf obo:VO_0000108, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_234
    ] .

obo:VO_0004547
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue Virus DNA Vaccine expressing prM/E proteins" ;
    rdfs:seeAlso "violinID: 3902" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004548
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue Virus DNA Vaccine D1ME-VRP" ;
    rdfs:seeAlso "violinID: 3903" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004549
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Dengue Virus DNA Vaccine encoding NS1" ;
    rdfs:seeAlso "violinID: 3904" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004550
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Feline immunodeficiency virus recombinant vector vaccine FIV-Delta-RT" ;
    rdfs:seeAlso "violinID: 3906" ;
    rdfs:subClassOf obo:VO_0001508, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11673
    ] .

obo:VO_0004551
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Foot-and-Mouth Disease Virus DNA Vaccine pSinCMV-Vac-MEG990" ;
    rdfs:seeAlso "violinID: 3907" ;
    rdfs:subClassOf obo:VO_0001213, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12110
    ] .

obo:VO_0004552
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Foot-and-Mouth Disease Virus Cationic Microparticle-coated DNA Vaccine" ;
    rdfs:seeAlso "violinID: 3908" ;
    rdfs:subClassOf obo:VO_0001213, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12110
    ] .

obo:VO_0004553
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "FMDV DNA Vaccine encoding P1 and non-structural proteins 2A, 3C, and 3D" ;
    rdfs:seeAlso "violinID: 3909" ;
    rdfs:subClassOf obo:VO_0001213, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12110
    ] .

obo:VO_0004554
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C. trachomatis DNA vaccine pWRG7079::MOMP" ;
    rdfs:seeAlso "violinID: 3910" ;
    rdfs:subClassOf obo:VO_0001207, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_813
    ] .

obo:VO_0004555
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C. pneumoniae DNA vaccine pHSP-60" ;
    rdfs:seeAlso "violinID: 3911" ;
    rdfs:subClassOf obo:VO_0012173, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83558
    ] .

obo:VO_0004556
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. tarda DNA vaccine pCE18" ;
    rdfs:seeAlso "violinID: 3912" ;
    rdfs:subClassOf obo:VO_0002506, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_636
    ] .

obo:VO_0004557
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. tarda DNA vaccine pCE6" ;
    rdfs:seeAlso "violinID: 3913" ;
    rdfs:subClassOf obo:VO_0002506, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_636
    ] .

obo:VO_0004558
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. tarda DNA vaccine pCEsa1" ;
    rdfs:seeAlso "violinID: 3914" ;
    rdfs:subClassOf obo:VO_0002506, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_636
    ] .

obo:VO_0004559
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. pylori DNA vaccine poipA" ;
    rdfs:seeAlso "violinID: 3915" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004560
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. pylori DNA vaccine pcDNA3.1-hspA" ;
    rdfs:seeAlso "violinID: 3916" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004561
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. pylori DNA vaccine pcDNA3.1-hspB" ;
    rdfs:seeAlso "violinID: 3917" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004562
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Leptospira interrogans DNA vaccine ompL1-pcDNA3.1(+)" ;
    rdfs:seeAlso "violinID: 3918" ;
    rdfs:subClassOf obo:VO_0000391, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0004563
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Leptospira interrogans DNA vaccine pTARGET/ LigBrep" ;
    rdfs:seeAlso "violinID: 3919" ;
    rdfs:subClassOf obo:VO_0000391, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_171
    ] .

obo:VO_0004564
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SIV recombinant vector vaccine rAd5/rLCMV" ;
    rdfs:seeAlso "violinID: 3920" ;
    rdfs:subClassOf obo:VO_0000751, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11723
    ] .

obo:VO_0004565
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Laryngotracheitis DNA Vaccine encoding gB" ;
    rdfs:seeAlso "violinID: 3921" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0004566
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Marburg virus recombinant vector vaccine MBGV GP/MBGV NP" ;
    rdfs:seeAlso "violinID: 3922" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004567
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. rhabdovirus DNA Vaccine encoding N and G" ;
    rdfs:seeAlso "violinID: 3923" ;
    rdfs:subClassOf obo:VO_0002455, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38142
    ] .

obo:VO_0004568
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine M2-DNA/M2-Ad" ;
    rdfs:seeAlso "violinID: 3924" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004569
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "N. meningitidis DNA vaccine P3A" ;
    rdfs:seeAlso "violinID: 3926" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_487
    ] .

obo:VO_0004570
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. aeruginosa DNA vaccine pGACAG-OprF/OprI" ;
    rdfs:seeAlso "violinID: 3927" ;
    rdfs:subClassOf obo:VO_0000393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0004571
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. aeruginosa DNA vaccine pGACAG-PcrV" ;
    rdfs:seeAlso "violinID: 3928" ;
    rdfs:subClassOf obo:VO_0000393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0004572
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. aeruginosa DNA vaccine pGACAG-OprF/OprI + pGACAG-PcrV + pGACAG-PilA" ;
    rdfs:seeAlso "violinID: 3929" ;
    rdfs:subClassOf obo:VO_0000393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0004573
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Y. pestis DNA vaccine YscF-2" ;
    rdfs:seeAlso "violinID: 3930" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004574
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BRSV DNA vaccine VCL-Fb" ;
    rdfs:seeAlso "violinID: 3931" ;
    rdfs:subClassOf obo:VO_0001507, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11246
    ] .

obo:VO_0004575
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Duck hepatitis virus 1 DNA vaccine pSCA/VP1" ;
    rdfs:seeAlso "violinID: 3932" ;
    rdfs:subClassOf obo:VO_0001528, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_691956
    ] .

obo:VO_0004576
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Hantavirus DNA vaccine pWRG/HTN-M" ;
    rdfs:seeAlso "violinID: 3933" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11598
    ] .

obo:VO_0004577
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RHDV DNA vaccine pcDNA-VP60" ;
    rdfs:seeAlso "violinID: 3934" ;
    rdfs:subClassOf obo:VO_0001382, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11976
    ] .

obo:VO_0004578
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HSV 2 DNA vaccine pVAX-HSV-2gD-HSP70" ;
    rdfs:seeAlso "violinID: 3935" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004579
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HRSV DNA vaccine DRF-412" ;
    rdfs:seeAlso "violinID: 3936" ;
    rdfs:subClassOf obo:VO_0002512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11250
    ] .

obo:VO_0004580
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HRSV DNA vaccine pND-G" ;
    rdfs:seeAlso "violinID: 3937" ;
    rdfs:subClassOf obo:VO_0002512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11250
    ] .

obo:VO_0004581
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IBV DNA vaccine pVAX1-N" ;
    rdfs:seeAlso "violinID: 3938" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ] .

obo:VO_0004582
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "IBV DNA vaccine pVAX-S1 with GM-CSF adjuvant" ;
    rdfs:seeAlso "violinID: 3939" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ] .

obo:VO_0004583
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "H. rhabdovirus DNA Vaccine encoding G" ;
    rdfs:seeAlso "violinID: 3940" ;
    rdfs:subClassOf obo:VO_0002455, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_38142
    ] .

obo:VO_0004584
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Infectious Bronchitis Virus DNA Vaccine encoding S1, N, and M" ;
    rdfs:seeAlso "violinID: 3941" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ] .

obo:VO_0004585
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Infectious Bursal Disease Virus DNA Vaccine expressing VP2" ;
    rdfs:seeAlso "violinID: 3942" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004586
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus DNA Vaccine P-JEV" ;
    rdfs:seeAlso "violinID: 3943" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11072
    ] .

obo:VO_0004587
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus DNA Vaccine pCJ-3/E encoding E" ;
    rdfs:seeAlso "violinID: 3944" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11072
    ] .

obo:VO_0004588
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "REV DNA vaccine VP22/gag and VP22/env" ;
    rdfs:seeAlso "violinID: 3946" ;
    rdfs:subClassOf obo:VO_0002544, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11636
    ] .

obo:VO_0004589
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. yoelii DNA vaccine pDIP/PyCSP. 1" ;
    rdfs:seeAlso "violinID: 3947" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004590
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. yoelii DNA vaccine encoding PySSP2" ;
    rdfs:seeAlso "violinID: 3948" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004591
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. berghei DNA vaccine encoding PbCSP" ;
    rdfs:seeAlso "violinID: 3949" ;
    rdfs:subClassOf obo:VO_0002513, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004592
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. yoelii DNA vaccine pPyHsp60-VR1012" ;
    rdfs:seeAlso "violinID: 3950" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004593
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. yoelii DNA vaccine encoding MSP1" ;
    rdfs:seeAlso "violinID: 3951" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004594
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. berghei DNA vaccine CSP-3p28" ;
    rdfs:seeAlso "violinID: 3952" ;
    rdfs:subClassOf obo:VO_0002513, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004595
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42" ;
    rdfs:seeAlso "violinID: 3953" ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004596
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SHIV DNA vaccine encoding env and gag" ;
    rdfs:seeAlso "violinID: 3954" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004597
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SHIV(Ba-L) DNA vaccine encoding env and gag" ;
    rdfs:seeAlso "violinID: 3955" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004598
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "GSK1437173A" ;
    rdfs:seeAlso "violinID: 3956" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004599
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Human cytomegalovirus DNA vaccine pcGB" ;
    rdfs:seeAlso "violinID: 3958" ;
    rdfs:subClassOf obo:VO_0001227, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10359
    ] .

obo:VO_0004600
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rBCG-SIVgag and rDIsSIVgag Prime-boost SHIV vaccine" ;
    rdfs:seeAlso "violinID: 3960" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004601
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. pneumoniae pspA-rBCG Vector Vaccine" ;
    rdfs:seeAlso "violinID: 3961" ;
    rdfs:subClassOf obo:VO_0000675, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1313
    ] .

obo:VO_0004602
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "T. gondii recombinant vaccine vector rBCGpMV361-TgCyP" ;
    rdfs:seeAlso "violinID: 3962" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004603
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "AE-Poxine" ;
    rdfs:seeAlso "violinID: 3963" ;
    rdfs:subClassOf obo:VO_0001522, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_70796
    ] .

obo:VO_0004604
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "autologous TriMix-DC melanoma vaccine" ;
    rdfs:seeAlso "violinID: 3966" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004605
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SL3261 expressing T. spiralis Ag30" ;
    rdfs:seeAlso "violinID: 3969" ;
    rdfs:subClassOf obo:VO_0002792 .

obo:VO_0004606
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Aeromonas hydrophila LSA34 vector vaccine WED/pUTDgap" ;
    rdfs:seeAlso "violinID: 3970" ;
    rdfs:subClassOf obo:VO_0002505, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_644
    ] .

obo:VO_0004607
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Actinobacillus pleuropneumoniae HS93Tox-/pIG-T1K vectored vaccine" ;
    rdfs:seeAlso "violinID: 3972" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_715
    ] .

obo:VO_0004608
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis BPZE vectored vaccine" ;
    rdfs:seeAlso "violinID: 3973" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0004609
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pCR3.1-VS-HSP65-TP-GRP6-M2" ;
    rdfs:seeAlso "violinID: 3987" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004610
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SRL172" ;
    rdfs:seeAlso "violinID: 4001" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004611
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VMCL" ;
    rdfs:seeAlso "violinID: 4019" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004612
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Newcastle disease virus lysate" ;
    rdfs:seeAlso "violinID: 4025" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004613
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "smallpox vaccine" ;
    rdfs:seeAlso "violinID: 4044" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004614
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "mRNA-Electroporated Dendritic Cells" ;
    rdfs:seeAlso "violinID: 4054" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004615
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pcDNA3-MCC/ST" ;
    rdfs:seeAlso "violinID: 4057" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004616
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Multivalent immunotherapeutic vaccine" ;
    rdfs:seeAlso "violinID: 4064" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004617
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "short overlapping peptides and full-length recombinant protein" ;
    rdfs:seeAlso "violinID: 4079" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004618
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BCG-DHTM" ;
    rdfs:seeAlso "violinID: 4082" ;
    rdfs:subClassOf obo:VO_0003130 .

obo:VO_0004619
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rSPV-PCV2-cap" ;
    rdfs:seeAlso "violinID: 4083" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_85708
    ] .

obo:VO_0004620
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "vFP89-H5" ;
    rdfs:seeAlso "violinID: 4084" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004621
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "vNDV-H5" ;
    rdfs:seeAlso "violinID: 4085" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004622
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "fp-IBD1" ;
    rdfs:seeAlso "violinID: 4087" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004623
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rDEV-re6 (H5)" ;
    rdfs:seeAlso "violinID: 4088" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004624
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "FPV-LT vaccine" ;
    rdfs:seeAlso "violinID: 4089" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0004625
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rFPV-IBDV-VP2" ;
    rdfs:seeAlso "violinID: 4091" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004626
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "LT-BCG- Ag85B /Rv3425" ;
    rdfs:seeAlso "violinID: 4092" ;
    rdfs:subClassOf obo:VO_0003130 .

obo:VO_0004627
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. T -PpSP15" ;
    rdfs:seeAlso "violinID: 4095" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004628
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "A2-CPA-CPB(-CTE)-recombinant L. tarentolae" ;
    rdfs:seeAlso "violinID: 4096" ;
    rdfs:subClassOf obo:VO_0012159, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5671
    ] .

obo:VO_0004629
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "L. T -HIV-1 Gag" ;
    rdfs:seeAlso "violinID: 4097" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004630
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "AdC68- rabies virus glycoprotein" ;
    rdfs:seeAlso "violinID: 4099" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004631
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rAd-GP (Ebola virus)" ;
    rdfs:seeAlso "violinID: 4100" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004632
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HVT-ND" ;
    rdfs:seeAlso "violinID: 4102" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11176
    ] .

obo:VO_0004633
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rHVT-H5" ;
    rdfs:seeAlso "violinID: 4103" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004634
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rHVT-H5 (clade 2.2 H5N1 HPAIV)" ;
    rdfs:seeAlso "violinID: 4104" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004635
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rSPV-MRP (Streptococcus suis)" ;
    rdfs:seeAlso "violinID: 4106" ;
    rdfs:subClassOf obo:VO_0002788, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1307
    ] .

obo:VO_0004636
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rSPV-HA1 (Swine influenza virus H1N1)" ;
    rdfs:seeAlso "violinID: 4107" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004637
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HS93Tox-/pIG-T1K" ;
    rdfs:seeAlso "violinID: 4108" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_715
    ] .

obo:VO_0004638
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-SIV/gp120" ;
    rdfs:seeAlso "violinID: 4110" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004639
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-rabies" ;
    rdfs:seeAlso "violinID: 4111" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004640
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "E. coli-CPPs (Edwardsiella tarda)" ;
    rdfs:seeAlso "violinID: 4112" ;
    rdfs:subClassOf obo:VO_0002506, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_636
    ] .

obo:VO_0004641
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CAdVax-ZEBOV/SEBOV" ;
    rdfs:seeAlso "violinID: 4113" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004642
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CAdVax-RVFV glycoprotein" ;
    rdfs:seeAlso "violinID: 4114" ;
    rdfs:subClassOf obo:VO_0012166, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11588
    ] .

obo:VO_0004643
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CAdVax-Den12/Den34" ;
    rdfs:seeAlso "violinID: 4115" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12637
    ] .

obo:VO_0004644
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CAdVax-Filoviruses (Ebola )" ;
    rdfs:seeAlso "violinID: 4116" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004645
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CAdVa-Filoviruses (EbMarburg viruses)" ;
    rdfs:seeAlso "violinID: 4117" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004646
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "cAdVaxM(fus)" ;
    rdfs:seeAlso "violinID: 4118" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0004647
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "cAdVax-based bivalent ebola virus vaccine (Sudan and Zaire species)" ;
    rdfs:seeAlso "violinID: 4119" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004648
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RB51-SRS2" ;
    rdfs:seeAlso "violinID: 4120" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] .

obo:VO_0004649
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RB51--MIC3/GRA6/MIC1/SRS2" ;
    rdfs:seeAlso "violinID: 4121" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_29176
    ] .

obo:VO_0004650
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BPZE1- FHA (H1N1/PR8 influenza A virus)" ;
    rdfs:seeAlso "violinID: 4122" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004651
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BV-RVG/RVG" ;
    rdfs:seeAlso "violinID: 4124" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004652
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BV-Dual-S1" ;
    rdfs:seeAlso "violinID: 4125" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004653
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "AcHERV-sH1N1-HA" ;
    rdfs:seeAlso "violinID: 4126" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004654
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BV-H5/H7/H9" ;
    rdfs:seeAlso "violinID: 4128" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004655
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BacMam-sHAPQ" ;
    rdfs:seeAlso "violinID: 4129" ;
    rdfs:subClassOf obo:VO_0001211, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10497
    ] .

obo:VO_0004656
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rBCGpMV361-TgCyP" ;
    rdfs:seeAlso "violinID: 4130" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5811
    ] .

obo:VO_0004657
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rBCG -Stx2B (Escherichia coli )" ;
    rdfs:seeAlso "violinID: 4131" ;
    rdfs:subClassOf obo:VO_0000041, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ] .

obo:VO_0004658
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rDEV-us78HA" ;
    rdfs:seeAlso "violinID: 4136" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004659
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VSV-DeltaG-H5 (H5N1)" ;
    rdfs:seeAlso "violinID: 4137" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004660
    obo:IAO_0000115 "An Ebola virus vaccine that uses a recombinant vesicular stomatitis virus (rVSV) vector expressing an Ebola filovirus glycoprotein" ;
    obo:IAO_0000117 "Oliver He, Kallan Roan" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=4140" ;
    a owl:Class ;
    rdfs:label "rVSV-EBOV" ;
    rdfs:seeAlso "violinID: 4140" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004661
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rVSV- SEBOV-GP and -VP40" ;
    rdfs:seeAlso "violinID: 4141" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004662
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rVSVDeltaG-ANDV-GPC" ;
    rdfs:seeAlso "violinID: 4142" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11598
    ] .

obo:VO_0004663
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVA-GnGc (Rift Valley fever virus)" ;
    rdfs:seeAlso "violinID: 4143" ;
    rdfs:subClassOf obo:VO_0012166, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11588
    ] .

obo:VO_0004664
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVA-SIV-CD40L" ;
    rdfs:seeAlso "violinID: 4144" ;
    rdfs:subClassOf obo:VO_0000751, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11723
    ] .

obo:VO_0004665
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVA-CCHF" ;
    rdfs:seeAlso "violinID: 4145" ;
    rdfs:subClassOf obo:VO_0001365, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11593
    ] .

obo:VO_0004666
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MVA-CHIKV" ;
    rdfs:seeAlso "violinID: 4146" ;
    rdfs:subClassOf obo:VO_0002785, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_37124
    ] .

obo:VO_0004667
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MVTT-HA-QH" ;
    rdfs:seeAlso "violinID: 4149" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004668
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. gordonii -M6-Sj-F1" ;
    rdfs:seeAlso "violinID: 4150" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004669
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Streptococcus gordonii-TTFC" ;
    rdfs:seeAlso "violinID: 4151" ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1485
    ] .

obo:VO_0004670
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "S. gordonii-PT" ;
    rdfs:seeAlso "violinID: 4152" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0004671
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SL3261-L. major" ;
    rdfs:seeAlso "violinID: 4153" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5664
    ] .

obo:VO_0004672
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SL3261-L. donovani" ;
    rdfs:seeAlso "violinID: 4154" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5661
    ] .

obo:VO_0004673
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SL3261-GFP expression and mIL-12 gene integration" ;
    rdfs:seeAlso "violinID: 4155" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004674
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SL3261-P. aeruginosa serogroup O11 O antigen" ;
    rdfs:seeAlso "violinID: 4156" ;
    rdfs:subClassOf obo:VO_0000393, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_287
    ] .

obo:VO_0004675
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SL3261- UreA and UreB" ;
    rdfs:seeAlso "violinID: 4157" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004676
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SL3261 expressing streptococcal M protein" ;
    rdfs:seeAlso "violinID: 4158" ;
    rdfs:subClassOf obo:VO_0002852, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1314
    ] .

obo:VO_0004677
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Schmidt-Ruppin Rous sarcoma virus-H7 (H7N7)" ;
    rdfs:seeAlso "violinID: 4159" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004678
    obo:IAO_0000117 "RS, NF, YH" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=4160", "https://pubmed.ncbi.nlm.nih.gov/18708674/" ;
    a owl:Class ;
    rdfs:label "RBD-rAAV-SARS-CoV" ;
    rdfs:seeAlso "violinID: 4160" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0004679
    obo:IAO_0000117 "RS, NF, YH" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=4161", "https://pubmed.ncbi.nlm.nih.gov/18289745/" ;
    a owl:Class ;
    rdfs:label "RBD-rAAV-SARS-CoV prime/RBD-specific T cell peptide boost" ;
    rdfs:seeAlso "violinID: 4161" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0004680
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rNDV-ILTV-gD" ;
    rdfs:seeAlso "violinID: 4162" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0004681
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rNDV-H5" ;
    rdfs:seeAlso "violinID: 4163" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004682
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rNDV-H5 ( HPAI H5N1 challenge in mule ducks)" ;
    rdfs:seeAlso "violinID: 4164" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004683
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rNDV-H6" ;
    rdfs:seeAlso "violinID: 4165" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004684
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rAPMV3-F (newcastle disease)" ;
    rdfs:seeAlso "violinID: 4167" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11176
    ] .

obo:VO_0004685
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BoHV-4-A-gD(cp)gD(106)DeltaTK" ;
    rdfs:seeAlso "violinID: 4168" ;
    rdfs:subClassOf obo:VO_0001366, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_39944
    ] .

obo:VO_0004686
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BoHV-4-A-IgK-VP2gD" ;
    rdfs:seeAlso "violinID: 4169" ;
    rdfs:subClassOf obo:VO_0001515, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40051
    ] .

obo:VO_0004687
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HSVT[VP7/6/2]" ;
    rdfs:seeAlso "violinID: 4172" ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10912
    ] .

obo:VO_0004688
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. S- H. pylori -opm26" ;
    rdfs:seeAlso "violinID: 4173" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0004689
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M.S-Delta-esx-3-IKEPLUS (M. tuberculosis)" ;
    rdfs:seeAlso "violinID: 4174" ;
    rdfs:subClassOf obo:VO_0000077 .

obo:VO_0004690
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "YF17D- HIV-1 p24" ;
    rdfs:seeAlso "violinID: 4175" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004691
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RCN-HA (H5N1)" ;
    rdfs:seeAlso "violinID: 4176" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004692
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RCN-F1-V (Yersinia pestis F1 and V)" ;
    rdfs:seeAlso "violinID: 4177" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004693
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RCN-rabies-G" ;
    rdfs:seeAlso "violinID: 4178" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004694
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RCN-IRES-tPA-YpF1( Yersinia pestis)" ;
    rdfs:seeAlso "violinID: 4179" ;
    rdfs:subClassOf obo:VO_0000648, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_632
    ] .

obo:VO_0004695
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PAV3-HA (H5N1)" ;
    rdfs:seeAlso "violinID: 4180" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004696
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PAV3-HA (A/Hanoi/30408/2005 H5N1)" ;
    rdfs:seeAlso "violinID: 4181" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004697
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rAd-P97c" ;
    rdfs:seeAlso "violinID: 4182" ;
    rdfs:subClassOf obo:VO_0000329, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2099
    ] .

obo:VO_0004698
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PrV-HA (swine-origin H1N1)" ;
    rdfs:seeAlso "violinID: 4183" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004699
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "PrV-PCV2-ORF2" ;
    rdfs:seeAlso "violinID: 4184" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_85708
    ] .

obo:VO_0004700
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rAdV-SFV-E2" ;
    rdfs:seeAlso "violinID: 4185" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0004701
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Typhi strain Ty21a-LPS-Shigella" ;
    rdfs:seeAlso "violinID: 4186" ;
    rdfs:subClassOf obo:VO_0000769, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_620
    ] .

obo:VO_0004702
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Typhi strain Ty21a-PA (Bacillus anthracis)" ;
    rdfs:seeAlso "violinID: 4187" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004703
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ty21a-O-Ps (Shigella dysenteriae )" ;
    rdfs:seeAlso "violinID: 4188" ;
    rdfs:subClassOf obo:VO_0000769, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_620
    ] .

obo:VO_0004704
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SabRV-SIV" ;
    rdfs:seeAlso "violinID: 4189" ;
    rdfs:subClassOf obo:VO_0000751, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11723
    ] .

obo:VO_0004705
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Poliovirus vector expressing model antigen H2-Kb-restricted CTL epitope" ;
    rdfs:seeAlso "violinID: 4190" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004706
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SG33-VP2/5" ;
    rdfs:seeAlso "violinID: 4191" ;
    rdfs:subClassOf obo:VO_0001515, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40051
    ] .

obo:VO_0004707
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Myxoma-FCV" ;
    rdfs:seeAlso "violinID: 4192" ;
    rdfs:subClassOf obo:VO_0001509, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11978
    ] .

obo:VO_0004708
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Maraba virus MG1" ;
    rdfs:seeAlso "violinID: 4193" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004709
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rvOka-HN (mumps virus)" ;
    rdfs:seeAlso "violinID: 4194" ;
    rdfs:subClassOf obo:VO_0000656, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11161
    ] .

obo:VO_0004710
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rOka-gD2- HSV-2" ;
    rdfs:seeAlso "violinID: 4195" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004711
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMV- SARS-CoV -S/Ssol" ;
    rdfs:seeAlso "violinID: 4196" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0004712
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMV- WNV" ;
    rdfs:seeAlso "violinID: 4197" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0004713
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMeV- SCD" ;
    rdfs:seeAlso "violinID: 4198" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004714
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMV-Ed-G" ;
    rdfs:seeAlso "violinID: 4199" ;
    rdfs:subClassOf obo:VO_0012169, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_121791
    ] .

obo:VO_0004715
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rLAG- PA-DCpep" ;
    rdfs:seeAlso "violinID: 4200" ;
    rdfs:subClassOf obo:VO_0000013, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1392
    ] .

obo:VO_0004716
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMCMV-TRP2" ;
    rdfs:seeAlso "violinID: 4201" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004717
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rCMV- EBOV" ;
    rdfs:seeAlso "violinID: 4202" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004718
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rCMV-TT" ;
    rdfs:seeAlso "violinID: 4203" ;
    rdfs:subClassOf obo:VO_0000640, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1485
    ] .

obo:VO_0004719
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CVB4/p24(73(3))" ;
    rdfs:seeAlso "violinID: 4204" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004720
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rVCG- Chlamydia-cholera" ;
    rdfs:seeAlso "violinID: 4205" ;
    rdfs:subClassOf obo:VO_0001207, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_813
    ] .

obo:VO_0004721
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "CVD 103-HgR- REPEC" ;
    rdfs:seeAlso "violinID: 4206" ;
    rdfs:subClassOf obo:VO_0000041, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83334
    ] .

obo:VO_0004722
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rVCG- MOMP/HSV-2-gD" ;
    rdfs:seeAlso "violinID: 4207" ;
    rdfs:subClassOf obo:VO_0001207, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_813
    ] .

obo:VO_0004723
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "pRP-RSV-HSV-1-gB" ;
    rdfs:seeAlso "violinID: 4208" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10298
    ] .

obo:VO_0004724
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "RSV-H7" ;
    rdfs:seeAlso "violinID: 4209" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004725
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-AHSV" ;
    rdfs:seeAlso "violinID: 4210" ;
    rdfs:subClassOf obo:VO_0001480, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40050
    ] .

obo:VO_0004726
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-BTV-VP2/VP5" ;
    rdfs:seeAlso "violinID: 4211" ;
    rdfs:subClassOf obo:VO_0001515, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40051
    ] .

obo:VO_0004727
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-HIV-2" ;
    rdfs:seeAlso "violinID: 4212" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004728
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-RV" ;
    rdfs:seeAlso "violinID: 4213" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004729
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "FP-AI-H5(H5N1)" ;
    rdfs:seeAlso "violinID: 4214" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004730
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-AI-H5(H5N1)" ;
    rdfs:seeAlso "violinID: 4215" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004731
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-WNV-prM/E" ;
    rdfs:seeAlso "violinID: 4216" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0004732
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-BTV-CP(VP2/VP5)" ;
    rdfs:seeAlso "violinID: 4218" ;
    rdfs:subClassOf obo:VO_0001515, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40051
    ] .

obo:VO_0004733
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-NiV-G" ;
    rdfs:seeAlso "violinID: 4219" ;
    rdfs:subClassOf obo:VO_0012169, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_121791
    ] .

obo:VO_0004734
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-NiV-F" ;
    rdfs:seeAlso "violinID: 4220" ;
    rdfs:subClassOf obo:VO_0012169, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_121791
    ] .

obo:VO_0004735
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-EIV (equine influenza virus H3N8)" ;
    rdfs:seeAlso "violinID: 4221" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004736
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-WNV-PrM/E (dogs and cats)" ;
    rdfs:seeAlso "violinID: 4222" ;
    rdfs:subClassOf obo:VO_0000752, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11082
    ] .

obo:VO_0004737
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-HIV-2- env/gag/pol" ;
    rdfs:seeAlso "violinID: 4223" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004738
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-RHDV (vCP309)" ;
    rdfs:seeAlso "violinID: 4224" ;
    rdfs:subClassOf obo:VO_0001382, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11976
    ] .

obo:VO_0004739
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-P53" ;
    rdfs:seeAlso "violinID: 4225" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004740
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-FL- env/gag" ;
    rdfs:seeAlso "violinID: 4226" ;
    rdfs:subClassOf obo:VO_0000843, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11768
    ] .

obo:VO_0004741
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-MV-HA/F" ;
    rdfs:seeAlso "violinID: 4227" ;
    rdfs:subClassOf obo:VO_0000654, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11234
    ] .

obo:VO_0004742
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "FP-IBDV-VP2" ;
    rdfs:seeAlso "violinID: 4228" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004743
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rFPV-AI-H5A-IL6" ;
    rdfs:seeAlso "violinID: 4229" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004744
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rFPV-ILTV" ;
    rdfs:seeAlso "violinID: 4230" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0004745
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "vFP89-HA (H5N1 HPAI virus)" ;
    rdfs:seeAlso "violinID: 4231" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004746
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rFPV-H5AI-L2" ;
    rdfs:seeAlso "violinID: 4232" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004747
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-AI-H5" ;
    rdfs:seeAlso "violinID: 4233" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004748
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rPFV-CSFV-E0" ;
    rdfs:seeAlso "violinID: 4234" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0004749
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMDV-IBDV-VP2" ;
    rdfs:seeAlso "violinID: 4237" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004750
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rFPV-IBDV-VP 2.4.3" ;
    rdfs:seeAlso "violinID: 4239" ;
    rdfs:subClassOf obo:VO_0001497, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10995
    ] .

obo:VO_0004751
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rFPV-NDV-H/F" ;
    rdfs:seeAlso "violinID: 4240" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11176
    ] .

obo:VO_0004752
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rFP-RPV-H/F" ;
    rdfs:seeAlso "violinID: 4241" ;
    rdfs:subClassOf obo:VO_0001455, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11241
    ] .

obo:VO_0004753
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Ac-CMV-S1 (infectious bronchitis virus)" ;
    rdfs:seeAlso "violinID: 4242" ;
    rdfs:subClassOf obo:VO_0001502, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11120
    ] .

obo:VO_0004754
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BV-GD-ORF2" ;
    rdfs:seeAlso "violinID: 4243" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_85708
    ] .

obo:VO_0004755
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rSPV/H3-2A-H1" ;
    rdfs:seeAlso "violinID: 4244" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004756
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HVT-ILT(FC-126 strain)" ;
    rdfs:seeAlso "violinID: 4245" ;
    rdfs:subClassOf obo:VO_0001231, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0004757
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rBCG-Ag85A/Ag85B" ;
    rdfs:seeAlso "violinID: 4246" ;
    rdfs:subClassOf obo:VO_0003130 .

obo:VO_0004758
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVA- AHS-VP2" ;
    rdfs:seeAlso "violinID: 4248" ;
    rdfs:subClassOf obo:VO_0001480, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40050
    ] .

obo:VO_0004759
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVTT-HA-QH (H5N1)" ;
    rdfs:seeAlso "violinID: 4249" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004760
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVTT-SIV-gpe" ;
    rdfs:seeAlso "violinID: 4250" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004761
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVTT- HPV16-E6/E7" ;
    rdfs:seeAlso "violinID: 4251" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004762
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rLSDV-Rabies-gP" ;
    rdfs:seeAlso "violinID: 4253" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004763
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rLSDV-RPV" ;
    rdfs:seeAlso "violinID: 4254" ;
    rdfs:subClassOf obo:VO_0001455, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11241
    ] .

obo:VO_0004764
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MG1-hDCT" ;
    rdfs:seeAlso "violinID: 4255" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0004765
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rORFV-D1701-V-HAh5n (H5N1)" ;
    rdfs:seeAlso "violinID: 4256" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004766
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rORFV-RabG" ;
    rdfs:seeAlso "violinID: 4257" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11292
    ] .

obo:VO_0004767
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rORFV-RHDV-VP60" ;
    rdfs:seeAlso "violinID: 4258" ;
    rdfs:subClassOf obo:VO_0001382, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11976
    ] .

obo:VO_0004768
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rORFV-CSFV-E2" ;
    rdfs:seeAlso "violinID: 4259" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11096
    ] .

obo:VO_0004769
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rORFV-p40(Borna disease virus)" ;
    rdfs:seeAlso "violinID: 4260" ;
    rdfs:subClassOf obo:VO_0001483, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12455
    ] .

obo:VO_0004770
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rORFV-PRV-gC/gD" ;
    rdfs:seeAlso "violinID: 4261" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004771
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-EHV-1- vP1014" ;
    rdfs:seeAlso "violinID: 4262" ;
    rdfs:subClassOf obo:VO_0001486, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10326
    ] .

obo:VO_0004772
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC- CDV-H/F" ;
    rdfs:seeAlso "violinID: 4263" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ] .

obo:VO_0004773
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC- CDV-H/F" ;
    rdfs:seeAlso "violinID: 4264" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ] .

obo:VO_0004774
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-HIV-1" ;
    rdfs:seeAlso "violinID: 4265" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004775
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-HIV-2" ;
    rdfs:seeAlso "violinID: 4266" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004776
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-JEV" ;
    rdfs:seeAlso "violinID: 4267" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11072
    ] .

obo:VO_0004777
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ALVAC-JEV" ;
    rdfs:seeAlso "violinID: 4268" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11072
    ] .

obo:VO_0004778
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-PRV- gII/ gp50" ;
    rdfs:seeAlso "violinID: 4270" ;
    rdfs:subClassOf obo:VO_0000750, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10345
    ] .

obo:VO_0004779
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-SIV" ;
    rdfs:seeAlso "violinID: 4271" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004780
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-JEV- prM/E/ NS1" ;
    rdfs:seeAlso "violinID: 4274" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11072
    ] .

obo:VO_0004781
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "VC-TetC/Tcf" ;
    rdfs:seeAlso "violinID: 4275" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0004782
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rAdV-SjTPI.opt" ;
    rdfs:seeAlso "violinID: 4280" ;
    rdfs:subClassOf obo:VO_0001229, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_6182
    ] .

obo:VO_0004783
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rPIV5-H3 (influenza virus)" ;
    rdfs:seeAlso "violinID: 4282" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004784
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rVEE-HA(H1N1)" ;
    rdfs:seeAlso "violinID: 4288" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004785
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rS.C-APP-ApxI/ApxII" ;
    rdfs:seeAlso "violinID: 4289" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_715
    ] .

obo:VO_0004786
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rS.C-APP-ApxIIA" ;
    rdfs:seeAlso "violinID: 4290" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_715
    ] .

obo:VO_0004787
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "dVV-HA5(H5N1)" ;
    rdfs:seeAlso "violinID: 4293" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004788
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rCPV-BTV-Cpox" ;
    rdfs:seeAlso "violinID: 4295" ;
    rdfs:subClassOf obo:VO_0001515, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_40051
    ] .

obo:VO_0004789
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rBCG-SIVgag" ;
    rdfs:seeAlso "violinID: 4299" ;
    rdfs:subClassOf obo:VO_0000751, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11723
    ] .

obo:VO_0004790
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rBCG-S1PT" ;
    rdfs:seeAlso "violinID: 4300" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_520
    ] .

obo:VO_0004791
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rBCGMSP1-15" ;
    rdfs:seeAlso "violinID: 4301" ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004792
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rMVA-SIV-CD40L" ;
    rdfs:seeAlso "violinID: 4302" ;
    rdfs:subClassOf obo:VO_0000295, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_12721
    ] .

obo:VO_0004793
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HVT-LT" ;
    rdfs:seeAlso "violinID: 4304" ;
    rdfs:subClassOf obo:VO_0001488, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10386
    ] .

obo:VO_0004794
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-Pf7" ;
    rdfs:seeAlso "violinID: 4306" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004795
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Toxminus-PLD toxoid" ;
    rdfs:seeAlso "violinID: 4308" ;
    rdfs:subClassOf obo:VO_0002789, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1719
    ] .

obo:VO_0004796
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "MVA-PvTRAP" ;
    rdfs:seeAlso "violinID: 4309" ;
    rdfs:subClassOf obo:VO_0000758, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004797
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "ChAd63 -PvTRAP" ;
    rdfs:seeAlso "violinID: 4310" ;
    rdfs:subClassOf obo:VO_0000758, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004798
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NILV-Py CSP" ;
    rdfs:seeAlso "violinID: 4311" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004799
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "SAd-ME.TRAP" ;
    rdfs:seeAlso "violinID: 4312" ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004800
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "NYVAC-CSP (malaria)" ;
    rdfs:seeAlso "violinID: 4313" ;
    rdfs:subClassOf obo:VO_0000761, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004801
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BDES-PfCSP (baculovirus dual expression system)" ;
    rdfs:seeAlso "violinID: 4314" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5820
    ] .

obo:VO_0004802
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "HDAd-sFsyn" ;
    rdfs:seeAlso "violinID: 4315" ;
    rdfs:subClassOf obo:VO_0002512, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11250
    ] .

obo:VO_0004803
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "LM1-2-E7" ;
    rdfs:seeAlso "violinID: 4316" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10566
    ] .

obo:VO_0004804
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "BL21(DE3)/pUTa-E + pET28a-FT" ;
    rdfs:seeAlso "violinID: 4317" ;
    rdfs:subClassOf obo:VO_0002506, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_636
    ] .

obo:VO_0004805
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "rVEE-Ebola-NP" ;
    rdfs:seeAlso "violinID: 4318" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_205488
    ] .

obo:VO_0004806
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "M. bovis DNA vaccine pCI-Ag85B" ;
    rdfs:seeAlso "violinID: 4319" ;
    rdfs:subClassOf obo:VO_0001519, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1765
    ] .

obo:VO_0004807
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Bacillus Calmette-Guérin Danish (BCG)" ;
    rdfs:seeAlso "violinID: 4320" ;
    rdfs:subClassOf obo:VO_0001519, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1765
    ] .

obo:VO_0004808
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "APSV Wetvax" ;
    rdfs:seeAlso "violinID: 4321" ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10245
    ] .

obo:VO_0004809
    obo:IAO_0000117 "RS, NF, YH" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=4322" ;
    obo:VO_0003099 "A/Brisbane/59/2007(H1N1), A/Brisbane/10/2007(H3N2), B/Florida/4/2006; Sanofi-Pasteur" ;
    a owl:Class ;
    rdfs:label "2008-2009 trivalent influenza vaccine" ;
    rdfs:seeAlso "violinID: 4322" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004810
    obo:IAO_0000115 "2010-2011 trivalent seasonal inactivated influenza vaccine 2010 consisting of Influenza A virus (A/California/7/2009(H1N1)), Influenza A virus (A/Texas/50/2012(H3N2)), Influenza B virus (B/Brisbane/60/2008)" ;
    obo:IAO_0000117 "RS, NF, YH, RV" ;
    obo:IAO_0000118 "2010-2011 trivalent seasonal inactivated influenza vaccine (A/California/7/09 (H1N1), A/Perth/16/2009 (H3N2), and B/Brisbane/60/2008)" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/25596819", "https://www.ncbi.nlm.nih.gov/pubmed/27317456" ;
    a owl:Class ;
    rdfs:label "2011–2012 trivalent inactivated vaccine (A/California/7/09 (H1N1), A/Perth /16/2009 (H3N2), and B/Brisbane/60/2008)" ;
    rdfs:seeAlso "violinID: 4324" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003479
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004898
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004811
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "Recombinant Aeromonas hydrophila vaccine (Aera)" ;
    rdfs:seeAlso "violinID: 4325" ;
    rdfs:subClassOf obo:VO_0002505, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_644
    ] .

obo:VO_0004812
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "C-KCE (vBAC-C-KCE)" ;
    rdfs:seeAlso "violinID: 4326" ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11309
    ] .

obo:VO_0004813
    obo:IAO_0000117 "RS, NF, YH" ;
    a owl:Class ;
    rdfs:label "v2RVFH" ;
    rdfs:seeAlso "violinID: 4327" ;
    rdfs:subClassOf obo:VO_0001455, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11241
    ] .

obo:VO_0004814
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "Biothrax (anthrax vaccine adsorbed) 0.5 ML Injectable Suspension" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/832682" ;
    obo:VO_0003198 832682 ;
    obo:VO_0003560 "BACILLUS ANTHRACIS STRAIN V770-NP1-R ANTIGENS 0.1 MG/ML Injectable Suspension [Biothrax]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1877319", "RXAUI: 7241001, 8235202, 8235203, 8231134", "TUI: T200" ;
    rdfs:label "Biothrax 0.5 ML Injectable Suspension"@en ;
    rdfs:subClassOf obo:VO_0004218, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004213
    ] .

obo:VO_0004815
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/805573" ;
    obo:VO_0003198 805573 ;
    a owl:Class ;
    rdfs:comment "CUI: C2364569", "RXAUI: 2861602", "TUI: T129, T121" ;
    rdfs:label "Rotavirus Vaccine, Live Attenuated, G1P[8] Human 89-12 strain"@en ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0010738
    ] .

obo:VO_0004816
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/805574" ;
    obo:VO_0003198 805574 ;
    a owl:Class ;
    rdfs:comment "CUI: C2364570", "RXAUI: 2861603", "TUI: T200" ;
    rdfs:label "Rotavirus Vaccine, Live Attenuated, G1P[8] Human 89-12 strain 1000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0004815 .

obo:VO_0004817
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/805577" ;
    obo:VO_0003198 805577 ;
    a owl:Class ;
    rdfs:comment "CUI: C2364572", "RXAUI: 2861607", "TUI: T200" ;
    rdfs:label "Rotavirus Vaccine, Live Attenuated, G1P[8] Human 89-12 strain 1000000 UNT/ML [Rotarix]"@en ;
    rdfs:subClassOf obo:VO_0010738 .

obo:VO_0004818
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/805579" ;
    obo:VO_0003198 805579 ;
    obo:VO_0003560 "Rotavirus Vaccine, Live Attenuated, G1P[8] Human 89-12 strain 1000000 UNT/ML Oral Suspension [Rotarix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2343398", "RXAUI: 8728820, 8728821, 2861609", "TUI: T200" ;
    rdfs:label "Rotarix, Rotavirus, live attenuated (RV1) G1P[8] Oral Vaccine"@en ;
    rdfs:subClassOf obo:VO_0004819, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004816
    ] .

obo:VO_0004819
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1182565" ;
    obo:VO_0003198 1182565 ;
    a owl:Class ;
    rdfs:comment "CUI: C3236400", "RXAUI: 3845652", "TUI: T200" ;
    rdfs:label "Rotarix Oral Liquid Product"@en ;
    rdfs:subClassOf obo:VO_0010738, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004818
    ] .

obo:VO_0004820
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798292" ;
    obo:VO_0003198 798292 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344315", "RXAUI: 2851375", "TUI: T116, T129, T121" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G4 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000097
    ] .

obo:VO_0004821
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798293" ;
    obo:VO_0003198 798293 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344316", "RXAUI: 2851376", "TUI: T200" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G4 Vaccine 1000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0004820 .

obo:VO_0004822
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798294" ;
    obo:VO_0003198 798294 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344317", "RXAUI: 2851377", "TUI: T116, T129, T121" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain P1A[8] Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000097
    ] .

obo:VO_0004823
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798288" ;
    obo:VO_0003198 798288 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344311", "RXAUI: 2851371", "TUI: T116, T129, T121" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G2 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000097
    ] .

obo:VO_0004824
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798290" ;
    obo:VO_0003198 798290 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344313", "RXAUI: 2851373", "TUI: T116, T129, T121" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G3 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000097
    ] .

obo:VO_0004825
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798286" ;
    obo:VO_0003198 798286 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344309", "RXAUI: 2851369", "TUI: T116, T129, T121" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G1 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000097
    ] .

obo:VO_0004826
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798291" ;
    obo:VO_0003198 798291 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344314", "RXAUI: 2851374", "TUI: T200" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G3 Vaccine 1100000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0004824 .

obo:VO_0004827
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798287" ;
    obo:VO_0003198 798287 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344310", "RXAUI: 2851370", "TUI: T200" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G1 Vaccine 1100000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0004825 .

obo:VO_0004828
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798295" ;
    obo:VO_0003198 798295 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344318", "RXAUI: 2851378", "TUI: T200" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain P1A[8] Vaccine 1150000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0004822 .

obo:VO_0004829
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798289" ;
    obo:VO_0003198 798289 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344312", "RXAUI: 2851372", "TUI: T200" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G2 Vaccine 1400000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0004823 .

obo:VO_0004830
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1182563" ;
    obo:VO_0003198 1182563 ;
    a owl:Class ;
    rdfs:comment "CUI: C3236398", "RXAUI: 3845650", "TUI: T200" ;
    rdfs:label "RotaTeq Oral Liquid Product"@en ;
    rdfs:subClassOf obo:VO_0000097 .

obo:VO_0004831
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798298" ;
    obo:VO_0003198 798298 ;
    a owl:Class ;
    rdfs:comment "CUI: C2344321", "RXAUI: 2851381", "TUI: T200" ;
    rdfs:label "Human-Bovine Reassortant Rotavirus Strain G1 Vaccine 1100000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain G2 Vaccine 1400000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain G3 Vaccine 1100000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain G4 Vaccine 1000000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain P1A[8] Vaccine 1150000 UNT/ML [RotaTeq]"@en ;
    rdfs:subClassOf obo:VO_0000097, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004821
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004826
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004827
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004828
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004829
    ] .

obo:VO_0004832
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798300" ;
    obo:VO_0003198 798300 ;
    obo:VO_0003560 "Human-Bovine Reassortant Rotavirus Strain G1 Vaccine 1100000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain G2 Vaccine 1400000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain G3 Vaccine 1100000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain G4 Vaccine 1000000 UNT/ML / Human-Bovine Reassortant Rotavirus Strain P1A[8] Vaccine 1150000 UNT/ML Oral Suspension [RotaTeq]" ;
    a owl:Class ;
    rdfs:comment "CUI: C1698233", "RXAUI: 8728818, 8728828, 2851383", "TUI: T200" ;
    rdfs:label "RotaTeq, Rotavirus, live pentavalent (RV5) Oral Vaccine"@en ;
    rdfs:subClassOf obo:VO_0004830, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004831
    ] .

obo:VO_0004833
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1607807" ;
    obo:VO_0003198 1607807 ;
    a owl:Class ;
    rdfs:comment "CUI: C4018289", "RXAUI: 6839906", "TUI: T200" ;
    rdfs:label "Quadracel Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0010736 .

obo:VO_0004834
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1988804" ;
    obo:VO_0003198 1988804 ;
    a owl:Class ;
    rdfs:comment "CUI: C4530672", "RXAUI: 9702160", "TUI: T200" ;
    rdfs:label "Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Quadracel]"@en ;
    rdfs:subClassOf obo:VO_0010736, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003204
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003210
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003374
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003385
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003388
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003395
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003843
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003844
    ] .

obo:VO_0004835
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1607808" ;
    obo:VO_0003198 1607808 ;
    obo:VO_0003560 "0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 80 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 16 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 64 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection [Quadracel]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4018290", "RXAUI: 7253752, 9702161", "TUI: T200" ;
    rdfs:label "Quadracel vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0004833, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004834
    ] .

obo:VO_0004836
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901509" ;
    obo:VO_0003198 901509 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741588", "RXAUI: 3060734", "TUI: T129, T121" ;
    rdfs:label "Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001246
    ] .

obo:VO_0004837
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901507" ;
    obo:VO_0003198 901507 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741586", "RXAUI: 3060732", "TUI: T129, T121" ;
    rdfs:label "Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001246
    ] .

obo:VO_0004838
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901511" ;
    obo:VO_0003198 901511 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741590", "RXAUI: 3060736", "TUI: T129, T121" ;
    rdfs:label "Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001246
    ] .

obo:VO_0004839
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901505" ;
    obo:VO_0003198 901505 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741584", "RXAUI: 3060730", "TUI: T129, T121" ;
    rdfs:label "Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0001246
    ] .

obo:VO_0004840
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901516" ;
    obo:VO_0003198 901516 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741589", "RXAUI: 3060735", "TUI: T200" ;
    rdfs:label "Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004836 .

obo:VO_0004841
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901508" ;
    obo:VO_0003198 901508 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741587", "RXAUI: 3060733", "TUI: T200" ;
    rdfs:label "Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004837 .

obo:VO_0004842
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901512" ;
    obo:VO_0003198 901512 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741591", "RXAUI: 3060737", "TUI: T200" ;
    rdfs:label "Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004838 .

obo:VO_0004843
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901506" ;
    obo:VO_0003198 901506 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741585", "RXAUI: 3060731", "TUI: T200" ;
    rdfs:label "Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004839 .

obo:VO_0004844
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1184384" ;
    obo:VO_0003198 1184384 ;
    a owl:Class ;
    rdfs:comment "CUI: C3238199", "RXAUI: 3840481", "TUI: T200" ;
    rdfs:label "Menveo Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0001246 .

obo:VO_0004845
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901516" ;
    obo:VO_0003198 901516 ;
    a owl:Class ;
    rdfs:comment "CUI: C2741595", "RXAUI: 3060741", "TUI: T200" ;
    rdfs:label "Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML [Menveo]"@en ;
    rdfs:subClassOf obo:VO_0001246, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004840
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004841
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004843
    ] .

obo:VO_0004846
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/901518" ;
    obo:VO_0003198 901518 ;
    obo:VO_0003560 "0.5 ML Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML Injection [Menveo]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2741597", "RXAUI: 7253602, 7251512, 7250930", "TUI: T200" ;
    rdfs:label "MENVEO vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0004844, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004845
    ] .

obo:VO_0004847
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593139" ;
    obo:VO_0003198 1593139 ;
    a owl:Class ;
    rdfs:comment "CUI: C3859502", "RXAUI: 6809461", "TUI: T200" ;
    rdfs:label "Trumenba Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003081 .

obo:VO_0004848
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593137" ;
    obo:VO_0003198 1593137 ;
    a owl:Class ;
    rdfs:comment "CUI: C3859500", "RXAUI: 6809459", "TUI: T200" ;
    rdfs:label "Neisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen 0.12 MG/ML / Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen 0.12 MG/ML [Trumenba]"@en ;
    rdfs:subClassOf obo:VO_0003081, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003367
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003369
    ] .

obo:VO_0004849
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593138" ;
    obo:VO_0003198 1593138 ;
    obo:VO_0003560 "meningococcal group B vaccine Prefilled Syringe [Trumenba]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3859501", "RXAUI: 6809460", "TUI: T200" ;
    rdfs:label "Trumenba vaccine Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0004847 .

obo:VO_0004850
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1593140" ;
    obo:VO_0003198 1593140 ;
    obo:VO_0003560 "0.5 ML Neisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen 0.12 MG/ML / Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen 0.12 MG/ML Prefilled Syringe [Trumenba]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3859503", "RXAUI: 6809462, 6809488, 7253600, 6809470", "TUI: T200" ;
    rdfs:label "Trumenba vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0004849, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004848
    ] .

obo:VO_0004851
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601406" ;
    obo:VO_0003198 1601406 ;
    a owl:Class ;
    rdfs:comment "CUI: C3883559", "RXAUI: 6827964", "TUI: T200" ;
    rdfs:label "Bexsero Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003066 .

obo:VO_0004852
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601404" ;
    obo:VO_0003198 1601404 ;
    a owl:Class ;
    rdfs:comment "CUI: C3883499", "RXAUI: 6827962", "TUI: T200" ;
    rdfs:label "meningococcal group B vaccine 0.1 MG/ML / Neisseria meningitidis serogroup B recombinant FHBP fusion protein antigen 0.1 MG/ML / Neisseria meningitidis serogroup B recombinant NHBA fusion protein antigen 0.1 MG/ML / Neisseria meningitidis serogroup B strain NZ98/254 outer membrane vesicle 0.05 MG/ML [Bexsero]"@en ;
    rdfs:subClassOf obo:VO_0003066, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003349
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003361
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003363
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003365
    ] .

obo:VO_0004853
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1601407" ;
    obo:VO_0003198 1601407 ;
    obo:VO_0003560 "0.5 ML meningococcal group B vaccine 0.1 MG/ML / Neisseria meningitidis serogroup B recombinant FHBP fusion protein antigen 0.1 MG/ML / Neisseria meningitidis serogroup B recombinant NHBA fusion protein antigen 0.1 MG/ML / Neisseria meningitidis serogroup B strain NZ98/254 outer membrane vesicle 0.05 MG/ML Prefilled Syringe [Bexsero]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3882668", "RXAUI: 7253601, 6827965, 6827966, 6827968, 6827967", "TUI: T200" ;
    rdfs:label "BEXSERO vaccine 0.5 ML Prefilled Syringe"@en ;
    rdfs:subClassOf obo:VO_0003359, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004852
    ] .

obo:VO_0004854
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/833079" ;
    obo:VO_0003198 833079 ;
    a owl:Class ;
    rdfs:comment "CUI: C2608637", "RXAUI: 2944708", "TUI: T116, T121" ;
    rdfs:label "smallpox vaccine live vaccinia virus"@en ;
    rdfs:subClassOf obo:VO_0000433, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000003
    ] .

obo:VO_0004855
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/833080" ;
    obo:VO_0003198 833080 ;
    a owl:Class ;
    rdfs:comment "CUI: C2608638", "RXAUI: 2944709", "TUI: T200" ;
    rdfs:label "smallpox vaccine live vaccinia virus 500000000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0004854 .

obo:VO_0004856
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1165898" ;
    obo:VO_0003198 1165898 ;
    a owl:Class ;
    rdfs:comment "CUI: C3220139", "RXAUI: 3828366", "TUI: T200" ;
    rdfs:label "ACAM2000 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000003 .

obo:VO_0004857
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/833086" ;
    obo:VO_0003198 833086 ;
    obo:VO_0003560 "smallpox vaccine live vaccinia virus 500000000 UNT/ML Injectable Solution [ACAM2000]" ;
    a owl:Class ;
    rdfs:comment "CUI: C2608644", "RXAUI: 2944716, 2944715, 7252433", "TUI: T200" ;
    rdfs:label "ACAM2000 smallpox (vaccinia) vaccine, live Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0004856, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004858
    ] .

obo:VO_0004858
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/833084" ;
    obo:VO_0003198 833084 ;
    a owl:Class ;
    rdfs:comment "CUI: C2608642", "RXAUI: 2944713", "TUI: T200" ;
    rdfs:label "smallpox vaccine live vaccinia virus 500000000 UNT/ML [ACAM2000]"@en ;
    rdfs:subClassOf obo:VO_0000003, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004855
    ] .

obo:VO_0004859
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/29503" ;
    obo:VO_0003198 29503 ;
    a owl:Class ;
    rdfs:comment "CUI: C0065944", "RXAUI: 436480, 5945194, 6410398", "TUI: T109, T129, T121" ;
    rdfs:label "meningococcal group C polysaccharide"@en ;
    rdfs:subClassOf obo:VO_0000919, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000031
    ] .

obo:VO_0004860
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/314725" ;
    obo:VO_0003198 314725 ;
    a owl:Class ;
    rdfs:comment "CUI: C0982276", "RXAUI: 1473942", "TUI: T109, T129, T121" ;
    rdfs:label "MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y"@en ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000031
    ] .

obo:VO_0004861
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1437844" ;
    obo:VO_0003198 1437844 ;
    a owl:Class ;
    rdfs:comment "C3666861", "RXAUI: 5495920", "TUI: T200" ;
    rdfs:label "meningococcal group C polysaccharide 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004859 .

obo:VO_0004862
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/350967" ;
    obo:VO_0003198 350967 ;
    a owl:Class ;
    rdfs:comment "CUI: C1167603", "RXAUI: 1545436", "TUI: T200" ;
    rdfs:label "meningococcal group C polysaccharide 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004859 .

obo:VO_0004863
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1437845" ;
    obo:VO_0003198 1437845 ;
    a owl:Class ;
    rdfs:comment "CUI: C3666862", "RXAUI: 5495921", "TUI: T200" ;
    rdfs:label "MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y 0.01 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004860 .

obo:VO_0004864
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/350966" ;
    obo:VO_0003198 350966 ;
    a owl:Class ;
    rdfs:comment "CUI: C1167602", "RXAUI: 1545435", "TUI: T200" ;
    rdfs:label "MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004860 .

obo:VO_0004865
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1437915" ;
    obo:VO_0003198 1437915 ;
    a owl:Class ;
    rdfs:comment "CUI: C3666883", "RXAUI: 5496016", "TUI: T200" ;
    rdfs:label "MenHibrix Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000031 .

obo:VO_0004866
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1437913" ;
    obo:VO_0003198 1437913 ;
    a owl:Class ;
    rdfs:comment "CUI: C3666881", "RXAUI: 5496014", "TUI: T200" ;
    rdfs:label "Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.005 MG/ML / meningococcal group C polysaccharide 0.01 MG/ML / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y 0.01 MG/ML [MenHibrix]"@en ;
    rdfs:subClassOf obo:VO_0000031, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004861
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004863
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004868
    ] .

obo:VO_0004867
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000118 "MenHibrix (meningococcal groups C and Y and Haemophilus b tetanus toxoid conjugate vaccine) 0.5 ML Injection" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1437916" ;
    obo:VO_0003198 1437916 ;
    obo:VO_0003560 "0.5 ML Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.005 MG/ML / meningococcal group C polysaccharide 0.01 MG/ML / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y 0.01 MG/ML Injection [MenHibrix]" ;
    a owl:Class ;
    rdfs:comment "CUI: C3537927", "RXAUI: 7253596, 7251659, 7250946", "TUI: T200" ;
    rdfs:label "MENHIBRIX vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0004865, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004866
    ] .

obo:VO_0004868
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1437843" ;
    obo:VO_0003198 1437843 ;
    a owl:Class ;
    rdfs:comment "CUI: C3666860", "RXAUI: 5495919", "TUI: T200" ;
    rdfs:label "Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.005 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0015013 .

obo:VO_0004869
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1299785" ;
    obo:VO_0003198 1299785 ;
    a owl:Class ;
    rdfs:comment "CUI: C3159361", "RXAUI: 4624424", "TUI: T129, T121" ;
    rdfs:label "HUMAN ADENOVIRUS E SEROTYPE 4 STRAIN CL-68578"@en ;
    rdfs:subClassOf obo:NCBITaxon_10508 .

obo:VO_0004870
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1183840" ;
    obo:VO_0003198 1183840 ;
    a owl:Class ;
    rdfs:comment "CUI: C3237660", "RXAUI: 3840468", "TUI: T200" ;
    rdfs:label "Menomune A/C/Y/W-135 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000072 .

obo:VO_0004871
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1802483" ;
    obo:VO_0003198 1802483 ;
    a owl:Class ;
    rdfs:comment "CUI: C4083103", "RXAUI: 8240118", "TUI: T129, T121" ;
    rdfs:label "HUMAN ADENOVIRUS B SEROTYPE 7 STRAIN 55142"@en ;
    rdfs:subClassOf obo:NCBITaxon_10508 .

obo:VO_0004872
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1153474" ;
    obo:VO_0003198 1153474 ;
    a owl:Class ;
    rdfs:comment "CUI: C3207956", "RXAUI: 3814359", "TUI: T200" ;
    rdfs:label "Adenovirus Type 4 Vaccine Live Oral Product"@en ;
    rdfs:subClassOf obo:VO_0003175 .

obo:VO_0004873
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1153475" ;
    obo:VO_0003198 1153475 ;
    a owl:Class ;
    rdfs:comment "CUI: C3207957", "RXAUI: 3814360", "TUI: T200" ;
    rdfs:label "Adenovirus Type 4 Vaccine Live Pill"@en ;
    rdfs:subClassOf obo:VO_0004872 .

obo:VO_0004874
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1099935" ;
    obo:VO_0003198 1099935 ;
    a owl:Class ;
    rdfs:comment "CUI: C3153709", "RXAUI: 6337850", "TUI: T200" ;
    rdfs:label "Adenovirus Type 4 Vaccine Live Delayed Release Oral Tablet"@en ;
    rdfs:subClassOf obo:VO_0004873 .

obo:VO_0004875
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1099936" ;
    obo:VO_0003198 1099936 ;
    a owl:Class ;
    rdfs:comment "CUI: C3153710", "RXAUI: 6337174, 6364229", "TUI: T200" ;
    rdfs:label "Adenovirus Type 4 Vaccine Live 32000 UNT Delayed Release Oral Tablet"@en ;
    rdfs:subClassOf obo:VO_0004874, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004876
    ] .

obo:VO_0004876
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1099934" ;
    obo:VO_0003198 1099934 ;
    a owl:Class ;
    rdfs:comment "CUI: C3153708", "RXAUI: 3638491", "TUI: T200" ;
    rdfs:label "Adenovirus Type 4 Vaccine Live 32000 UNT"@en ;
    rdfs:subClassOf obo:VO_0003175 .

obo:VO_0004877
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1153476" ;
    obo:VO_0003198 1153476 ;
    a owl:Class ;
    rdfs:comment "CUI: C3207958", "RXAUI: 3814361", "TUI: T200" ;
    rdfs:label "Adenovirus Type 7 Vaccine Live Oral Product"@en ;
    rdfs:subClassOf obo:VO_0003176 .

obo:VO_0004878
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1153661" ;
    obo:VO_0003198 1153661 ;
    a owl:Class ;
    rdfs:comment "CUI: C3208141", "RXAUI: 3814362", "TUI: T200" ;
    rdfs:label "Adenovirus Type 7 Vaccine Live Pill"@en ;
    rdfs:subClassOf obo:VO_0004877 .

obo:VO_0004879
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1099939" ;
    obo:VO_0003198 1099939 ;
    a owl:Class ;
    rdfs:comment "CUI: C3153712", "RXAUI: 6337292", "TUI: T200" ;
    rdfs:label "Adenovirus Type 7 Vaccine Live Delayed Release Oral Tablet"@en ;
    rdfs:subClassOf obo:VO_0004878 .

obo:VO_0004880
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1099940" ;
    obo:VO_0003198 1099940 ;
    a owl:Class ;
    rdfs:comment "CUI: C3153713", "RXAUI: 6337842, 6364883", "TUI: T200" ;
    rdfs:label "Adenovirus Type 7 Vaccine Live 32000 UNT Delayed Release Oral Tablet"@en ;
    rdfs:subClassOf obo:VO_0004879, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004881
    ] .

obo:VO_0004881
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1099938" ;
    obo:VO_0003198 1099938 ;
    a owl:Class ;
    rdfs:comment "CUI: C3153711", "RXAUI: 3638495", "TUI: T200" ;
    rdfs:label "Adenovirus Type 7 Vaccine Live 32000 UNT"@en ;
    rdfs:subClassOf obo:VO_0003176 .

obo:VO_0004882
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/568054" ;
    obo:VO_0003198 568054 ;
    a owl:Class ;
    rdfs:comment "CUI: C1600470", "RXAUI: 2283589", "TUI: T200" ;
    rdfs:label "meningococcal group A polysaccharide 0.1 MG/ML / meningococcal group C polysaccharide 0.1 MG/ML / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP W-135 0.1 MG/ML / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y 0.1 MG/ML [Menomune A/C/Y/W-135]"@en ;
    rdfs:subClassOf obo:VO_0000072, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004862
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004889
    ] .

obo:VO_0004883
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658227" ;
    obo:VO_0003198 1658227 ;
    obo:VO_0003560 "meningococcal group A polysaccharide / meningococcal group C polysaccharide / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP W-135 / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y Injection [Menomune A/C/Y/W-135]" ;
    a owl:Class ;
    rdfs:comment "CUI: C4033800", "RXAUI: 7252552", "TUI: T200" ;
    rdfs:label "Menomune A/C/Y/W-135 Vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0004870 .

obo:VO_0004884
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658228" ;
    obo:VO_0003198 1658228 ;
    a owl:Class ;
    rdfs:comment "CUI: C3887764", "RXAUI: 7253594, 7252562, 7252553", "TUI: T200" ;
    rdfs:label "Menomune A/C/Y/W-135 Vaccine 0.5 ML Injection"@en ;
    rdfs:subClassOf obo:VO_0004883, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004882
    ] .

obo:VO_0004885
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/207269" ;
    obo:VO_0003198 207269 ;
    obo:VO_0003560 "meningococcal group A polysaccharide 0.1 MG/ML / meningococcal group C polysaccharide 0.1 MG/ML / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP W-135 0.1 MG/ML / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y 0.1 MG/ML Injectable Solution [Menomune A/C/Y/W-135]" ;
    a owl:Class ;
    rdfs:comment "CUI: C0708576", "RXAUI: 3051640, 7253593, 5944304, 1155623", "TUI: T200" ;
    rdfs:label "Menomune A/C/Y/W-135 Vaccine Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0004870, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004882
    ] .

obo:VO_0004886
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/314724" ;
    obo:VO_0003198 314724 ;
    a owl:Class ;
    rdfs:comment "CUI: C0982275", "RXAUI: 1473937", "TUI: T200" ;
    rdfs:label "MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP W-135"@en ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0004887
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/350965" ;
    obo:VO_0003198 350965 ;
    a owl:Class ;
    rdfs:comment "CUI: C1167601", "RXAUI: 1545434", "TUI: T200" ;
    rdfs:label "MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP W-135 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004886 .

obo:VO_0004888
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/29501" ;
    obo:VO_0003198 29501 ;
    a owl:Class ;
    rdfs:comment "CUI: C0065942", "RXAUI: 436468, 6410396, 2719265, 5945192", "TUI: T200" ;
    rdfs:label "meningococcal group A polysaccharide"@en ;
    rdfs:subClassOf obo:VO_0000919 .

obo:VO_0004889
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/328467" ;
    obo:VO_0003198 328467 ;
    a owl:Class ;
    rdfs:comment "CUI: C1123385", "RXAUI: 1505209", "TUI: T200" ;
    rdfs:label "meningococcal group A polysaccharide 0.1 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0004888 .

obo:VO_0004890
    obo:IAO_0000115 "The gH1-Qbeta vaccine is a novel pandemic-influenza vaccine produced by covalently linking the globular head domain of haemagglutinin (gH1) from A/California/07/09 produced in E. coli to VLPs from the bacteriophage Qbeta" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/30573748" ;
    obo:VO_0003146 "15 µg HA from Influenza A virus (A/California/7/2009(H1N1))" ;
    obo:VO_0003147 "VLPs from the bacteriophage Qbeta" ;
    a owl:Class ;
    rdfs:label "gH1-Qbeta vaccine"@en ;
    rdfs:subClassOf obo:VO_0000578, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:VO_0000200
    ] .

obo:VO_0004891
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/29535712" ;
    obo:VO_0003146 "100 µg CN54gp140" ;
    obo:VO_0003147 "GLA-AF" ;
    dc:description "A recombinant uncleaved clade C HIV-1 envelope gp140 protein (CN54gp140)" ;
    a owl:Class ;
    rdfs:label "CN54gp140 + GLA"@en ;
    rdfs:subClassOf obo:VO_0000295 .

obo:VO_0004892
    obo:IAO_0000119 "https://www.advent-gmp.com/about-us/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:comment """ADVENT SRL
VIA CRESCENZIO 9
ROMA, ROMA, 00193  Italy
+39-0691093692
Company Type: Corporation Subsidiary
http://www.hoovers.com/company-information/cs/company-profile.advent_srl.aebb99e74ae57b09.html?aka_re=1""" ;
    rdfs:label "Advent Srl., Italy"@en .

obo:VO_0004893
    obo:IAO_0000115 "Fluenz™ is a seasonal trivalent live attenuated influenza vaccine (LAIV) administered intranasally. The vaccine contained A/California/07/2009 (H1N1) pdm09-like strain, A/Victoria/361/2011 (H3N2)-like strain, and B/Massachusetts/2/2012-like strain." ;
    obo:IAO_0000117 "Randi Rita, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/26148331" ;
    obo:VO_0003146 "Influenza A virus (A/California/7/2009(H1N1)), Influenza A virus (A/Victoria/361/2011(H3N2)), Influenza B virus (B/Massachusetts/02/2012" ;
    a owl:Class ;
    rdfs:label "Fluenz"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0001015
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000694 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004894
    obo:IAO_0000115 "quadrivalent seasonal inactivated influenza vaccine 2014 consisting of Influenza A virus (A/California/7/2009(H1N1)), Influenza A virus (A/Texas/50/2012(H3N2)), Influenza B virus (B/Brisbane/60/2008), Influenza B virus (B/Massachusetts/02/2012)" ;
    obo:IAO_0000117 "Randi Rita, Olilver He" ;
    obo:IAO_0000119 "Avey et al 2019, paper submitted" ;
    obo:VO_0003146 "Influenza A virus (A/California/7/2009(H1N1)), Influenza A virus (A/Texas/50/2012(H3N2)), Influenza B virus (B/Brisbane/60/2008), Influenza B virus (B/Massachusetts/02/2012)" ;
    a owl:Class ;
    rdfs:label "quadrivalent seasonal inactivated influenza vaccine 2014"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0004895
    obo:IAO_0000112 "‘F’ (intended to refer to a female biological sex), ‘Female’, ‘Woman’, ‘0’ (intended to refer to a female biological sex)" ;
    obo:IAO_0000115 "A biological sex datum that represents the biological sex of an animal (including human) as being female." ;
    obo:IAO_0000117 "Paul Fabry, Oliver He" ;
    a owl:Class ;
    rdfs:label "female biological sex datum"@en ;
    rdfs:subClassOf obo:VO_0001194 .

obo:VO_0004896
    obo:IAO_0000112 "‘I’ (intended to refer to an intersex biological sex), ‘Intersex’, ‘Hermaphrodite’, ‘Pseudo-hermaphrodite’, ‘2’ (intended to refer to an intersex biological sex)" ;
    obo:IAO_0000115 "A biological sex datum that represents the biological sex of an animal (including human) as being intersex." ;
    obo:IAO_0000117 "Paul Fabry, Oliver He" ;
    a owl:Class ;
    rdfs:label "intersex biological sex datum"@en ;
    rdfs:subClassOf obo:VO_0001194 .

obo:VO_0004897
    obo:IAO_0000115 "A vaccine against coronavirus infection" ;
    obo:IAO_0000117 "Hong Yu, Oliver He" ;
    a owl:Class ;
    rdfs:label "coronavirus vaccine"@en ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11118
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11118
    ] .

obo:VO_0004898
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "https://www.fludb.org/brc/fluStrainDetails.spg?strainName=A/Perth/16/2009(H3N2)&decorator=influenza" ;
    a owl:Class ;
    rdfs:comment """Recommended by WHO for Vaccines: 
2011-2012 Northern Hemisphere
2010 Southern Hemisphere
2011 Southern Hemisphere
2012 Southern Hemisphere
2010-2011 Northern Hemisphere""" ;
    rdfs:label "Influenza A virus A/Perth/16/2009 (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085 .

obo:VO_0004899
    obo:IAO_0000115 "2012-2013 trivalent seasonal inactivated influenza vaccine 2012-2013  Influenza A virus (A/California/7/2009 (H1N1)), Influenza A virus (A/Victoria/361/2011 (H3N2)), and Influenza B virus (B/Wisconsin/1/2010)" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/?term=30843873" ;
    a owl:Class ;
    rdfs:label "2012-2013 seasonal trivalent inactivated influenza vaccine (A/California/7/2009 (H1N1), A/Victoria/361/2011 (H3N2), and B/Wisconsin/1/2010)"@en ;
    rdfs:subClassOf obo:VO_0000642, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004901
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004902
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ] .

obo:VO_0004900
    obo:IAO_0000118 "MERS-CoV vaccine" ;
    a owl:Class ;
    rdfs:label "MERS vaccine"@en ;
    rdfs:subClassOf obo:VO_0004897, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1335626
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1335626
    ] .

obo:VO_0004901
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "https://www.drugbank.ca/drugs/DB14396" ;
    a owl:Class ;
    rdfs:label "influenza B virus B/Wisconsin/1/2010 antigen"@en ;
    rdfs:subClassOf obo:VO_0015086 .

obo:VO_0004902
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "https://www.fludb.org/brc/fluStrainDetails.spg?strainName=A/Victoria/361/2011(H3N2)&decorator=influenza" ;
    a owl:Class ;
    rdfs:comment """Recommended by WHO for Vaccines:
2013 Southern Hemisphere
2014 Southern Hemisphere
2012-2013 Northern Hemisphere
2013-2014 Northern Hemisphere""" ;
    rdfs:label "influenza A virus A/Victoria/361/2011 (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085 .

obo:VO_0004903
    obo:IAO_0000115 "Inactivated monovalent influenza A/H5N1 (3.75 mcg hemagglutinin [HA] A/Indonesia/05/2005) split-virus (SV) vaccine (Sanofi)" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/28099485", "https://www.ncbi.nlm.nih.gov/pubmed/30566602" ;
    a owl:Class ;
    rdfs:label "Inactivated monovalent influenza A/H5N1 (3.75 mcg hemagglutinin [HA] A/Indonesia/05/2005) split-virus (SV) vaccine (Sanofi)"@en ;
    rdfs:subClassOf obo:VO_0000065, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004904
    ] .

obo:VO_0004904
    obo:IAO_0000119 "https://www.fludb.org/brc/fluStrainDetails.spg?strainName=A/Indonesia/5/2005(H5N1)&tabName=17535101%20No2&decorator=influenza&context=1544988803656" ;
    a owl:Class ;
    rdfs:label "Influenza A virus (A/Indonesia/05/2005) antigen"@en ;
    rdfs:subClassOf obo:VO_0015085 .

obo:VO_0004905
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884803/" ;
    a owl:Class ;
    rdfs:label "MERS-CoV S protein with alum and CpG adjuvant"@en ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0004907
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:VO_0000884
                obo:VO_0001237
            )
        ]
    ] .

obo:VO_0004906
    a owl:Class ;
    rdfs:label "MERS-CoV protein"@en ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0004907
    a owl:Class ;
    rdfs:label "MERS-CoV S protein"@en ;
    rdfs:subClassOf obo:VO_0004906 .

obo:VO_0004908
    obo:IAO_0000115 "A coronavirus vaccine against the infection of SARS-CoV-2 (cause of COVID-19)" ;
    obo:IAO_0000117 "Oliver He, Philip Huang, Anthony Huffman" ;
    obo:IAO_0000118 "SARS-CoV-2 vaccine" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/COVID-19_vaccine", "https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-vaccines" ;
    a owl:Class ;
    rdfs:label "COVID-19 vaccine"@en ;
    rdfs:subClassOf obo:VO_0004897, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0004909
    obo:IAO_0000115 "a shortcut object property that represents a relation between a vaccine and a disease process where the vaccine immunizes a host against a disease process." ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:ObjectProperty ;
    rdfs:label "immunizes against disease process"@en .

obo:VO_0004910
    obo:IAO_0000115 "A Plasmodium falciparum vaccine that is composed of aseptic, purified, live (metabolically active), radiation-attenuated, cryopreserved Plasmodium falciparum sporozite." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "Plasmodium falciparum sporozite Vaccine" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/26469720", "https://www.ncbi.nlm.nih.gov/pubmed/28216244" ;
    obo:VO_0003159 "Sanaria Inc., Rockville, MD" ;
    a owl:Class ;
    rdfs:label "PfSPZ Vaccine"@en ;
    rdfs:subClassOf obo:VO_0000087 .

obo:VO_0004911
    obo:IAO_0000115 "The fully infectious PfSPZ are attenuated in vivo by concomitant administration of an anti-malarial drug (chloroquine). Chloroquine kills disease-associated blood stages but does not affect pre-erythrocytic (sporozoite or liver) stages, which are exposed to the host's immune system. Sporozoites-induced protection is mediated by immunity against pre-erythrocytic stages." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "PfSPZ Chemoprophylaxis Vaccine" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775905/", "https://www.ncbi.nlm.nih.gov/pubmed/26469720", "https://www.ncbi.nlm.nih.gov/pubmed/28199305" ;
    obo:VO_0003159 "Sanaria Inc., Rockville, MD" ;
    a owl:Class ;
    rdfs:label "PfSPZ-CVac"@en ;
    rdfs:subClassOf obo:VO_0000087 .

obo:VO_0004912
    obo:IAO_0000115 "Sanaria® PfSPZ-GA1 consists of purified, aseptic, cryopreserved Pf sporozoites (NF54 strain) genetically attenuated by removal of the b9 and slarp genes to halt development in the early liver stages." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/26469720" ;
    obo:VO_0003159 "Sanaria Inc., Rockville, MD" ;
    a owl:Class ;
    rdfs:comment "The parasite line was generated by the Leiden University Medical Center (LUMC) and RUMC in collaboration with Sanaria. PfΔb9Δslarp parasites invade hepatocytes but are incapable of sustaining liver stage development, similar to radiation-attenuated PfSPZ. The potential advantages of PfSPZ-GA1 are that (1) the PfSPZ are homogenous and have a precisely characterized genetic basis for attenuation; (2) manufacturing PfSPZ-GA1 cannot result in accidental exposure of staff to infectious parasites, thereby simplifying the approach to safety of operators and lowering costs. PfSPZ-GA1 also has the potential to induce more efficient protection than the radiation-attenuated PfSPZ Vaccine due to a different pattern of developmental arrest and antigen expression. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077156/" ;
    rdfs:label "PfSPZ-GA1"@en ;
    rdfs:subClassOf obo:VO_0000087 .

obo:VO_0004913
    obo:IAO_0000115 "a vaccine role that inheres in a vaccine using virus-like particles (VLPs), multiprotein structures that mimic the organization and conformation of authentic native viruses but lack the viral genome, potentially yielding safer and cheaper vaccines." ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    obo:IAO_0000118 "virus like particle vaccine role" ;
    obo:IAO_0000119 "https://pubmed.ncbi.nlm.nih.gov/20923267/" ;
    a owl:Class ;
    rdfs:label "virus-like particle vaccine role"@en ;
    rdfs:subClassOf obo:VO_0000615 .

obo:VO_0004914
    obo:IAO_0000115 "A vaccine that uses virus-like particles (VLPs), multiprotein structures that mimic the organization and conformation of authentic native viruses but lack the viral genome, potentially yielding safer and cheaper vaccines." ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    obo:IAO_0000118 "virus like particle vaccine" ;
    obo:IAO_0000119 "https://pubmed.ncbi.nlm.nih.gov/20923267/" ;
    a owl:Class ;
    rdfs:label "virus-like particle vaccine"@en ;
    rdfs:subClassOf obo:VO_0000001, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0004913
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0004913
    ] .

obo:VO_0004915
    obo:IAO_0000115 "vaccine-induced T-helper 1 type immune response that is indicated by the presence of Interferon-gamma production" ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:label "vaccine specific interferon-γ immune response"@en ;
    rdfs:subClassOf obo:VO_0000100 .

obo:VO_0004916
    obo:IAO_0000115 "vaccine-induced T-helper 1 type immune response that is indicated by the presence of interleukin-2 production" ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:label "vaccine specific IL-2 immune response"@en ;
    rdfs:subClassOf obo:VO_0000100 .

obo:VO_0004917
    obo:IAO_0000115 "vaccine-induced T-helper 2 type immune response that is indicated by the presence of interleukin-4 production" ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:label "vaccine specific interleukin-4 response"@en ;
    rdfs:subClassOf obo:VO_0000101 .

obo:VO_0004918
    obo:IAO_0000115 "vaccine-induced T-helper 2 type immune response that is indicated by the presence of interleukin-10 production" ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:label "vaccine specific interleukin-10 response"@en ;
    rdfs:subClassOf obo:VO_0000101 .

obo:VO_0004919
    obo:IAO_0000115 "vaccine-induced T-helper 1 type immune response that is indicated by the presence of IgG2a production" ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC101669/" ;
    a owl:Class ;
    rdfs:label "vaccine specific Th1 immune response indicated by IgG2a  production"@en ;
    rdfs:subClassOf obo:VO_0000100 .

obo:VO_0004920
    obo:IAO_0000115 "vaccine-induced T-helper 2 type immune response that is indicated by the presence of IgG1 production" ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC101669/" ;
    a owl:Class ;
    rdfs:label "vaccine specific Th2 immune response indicated by IgG1  production"@en ;
    rdfs:subClassOf obo:VO_0000101 .

obo:VO_0004921
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855." ;
    rdfs:label "human age"@en ;
    rdfs:subClassOf obo:PATO_0000011 .

obo:VO_0004922
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855." ;
    rdfs:label "child age"@en ;
    rdfs:subClassOf obo:VO_0004921 .

obo:VO_0004923
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855." ;
    rdfs:label "adolescence age"@en ;
    rdfs:subClassOf obo:VO_0004921 .

obo:VO_0004924
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855." ;
    rdfs:label "adult age"@en ;
    rdfs:subClassOf obo:VO_0004921 .

obo:VO_0004925
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855." ;
    rdfs:label "senior age"@en ;
    rdfs:subClassOf obo:VO_0004921 .

obo:VO_0004926
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:label "age range at vaccination"@en ;
    rdfs:subClassOf obo:IAO_0000109 .

obo:VO_0004927
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855." ;
    rdfs:label "human age range at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004926 .

obo:VO_0004928
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human child age range at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004927 .

obo:VO_0004929
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human adult age range at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004927 .

obo:VO_0004930
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human senior age range at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004927 .

obo:VO_0004931
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    obo:IAO_0000118 "human age 13 to 18 years at vaccination" ;
    obo:IAO_0000119 "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855." ;
    rdfs:label "human adolescence age range at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004927 .

obo:VO_0004932
    obo:IAO_0000115 "A pharmaceutical company that was founded in 1953 by Paul Janssen, is headquartered in Beerse, Belgium, and owned by Johnson & Johnson." ;
    obo:IAO_0000117 "Oliver He, Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Janssen_Pharmaceutica", "https://www.janssen.com/us/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Janssen Pharmaceutica"@en .

obo:VO_0004933
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 1 to 2 months at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004934
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 4 months at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004935
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 11 to 12 years at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004936
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 4 to 6 years at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004937
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 7 to 11 months at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004938
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 12 to 23 months at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004939
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 2 to 3 years at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004940
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 6 months at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004941
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 7 to 10 years at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004942
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 19 to 26 years at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004929 .

obo:VO_0004943
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age 27 to 59 years at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004929 .

obo:VO_0004944
    obo:IAO_0000115 "The age with the range from the birth to one month after birth at when a vaccination is taken. HepB vaccination is sometimes taken within 12  hours after birth." ;
    obo:IAO_0000117 "Anna Maria Masci, Anthony Huffman, Oliver He, Jie Zheng" ;
    obo:IAO_0000118 "newborn age range at human vaccination" ;
    obo:IAO_0000119 "https://www.cdc.gov/vaccines/parents/diseases/hepb.html" ;
    a owl:Class ;
    rdfs:comment "The human age is classified into four categories as Child (0-12 years), Adolescence (13-18 years), Adult (19-59 years) and Senior Adult (60 years and above) which is discussed in the paper. Reference: https://ieeexplore.ieee.org/abstract/document/6416855.", "https://www.cdc.gov/vaccines/vpd/vaccines-age.html" ;
    rdfs:label "human age within one month at vaccination"@en ;
    rdfs:subClassOf obo:VO_0004928 .

obo:VO_0004945
    obo:IAO_0000117 "Philip Huang, Oliver He"@zh ;
    obo:IAO_0000118 "康希诺生物"@zh ;
    obo:IAO_0000119 "http://www.cansinotech.com/", "https://en.wikipedia.org/wiki/CanSino_Biologics" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "CanSino Biologics"@en .

obo:VO_0004946
    obo:IAO_0000115 "A German biotechnology company that is dedicated to the development and manufacture of active immunotherapies for a patient-specific approach to the treatment of serious diseases." ;
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/BioNTech" ;
    oboInOwl:hasURI "https://biontech.de/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "BioNTech"@en .

obo:VO_0004947
    obo:IAO_0000115 "An American multinational pharmaceutical corporation headquartered in New York City."@zh ;
    obo:IAO_0000117 "Philip, Oliver" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Pfizer"@zh, "https://www.pfizer.com/"@zh ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Pfizer Inc."@en .

obo:VO_0004948
    obo:IAO_0000115 "A British-Swedish multinational pharmaceutical and biopharmaceutical company with its headquarters in Cambridge, United Kingdom and Södertälje, Sweden. AstraZeneca makes products for major disease areas including cancer, cardiovascular, gastrointestinal, infection, neuroscience, respiratory and inflammation." ;
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/AstraZeneca" ;
    oboInOwl:hasURI "https://www.astrazeneca.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "AstraZeneca"@en .

obo:VO_0004949
    obo:IAO_0000117 "Philip, Oliver" ;
    obo:IAO_0000119 "https://www.cnbg.com.cn/", "https://www.trialsitenews.com/chinas-beijing-institute-of-biological-products-covid-19-vaccine-reportedly-ready-for-phase-iii/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Beijing Institute of Biological Products"@en .

obo:VO_0004950
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000118 "Sinopharm", "Sinopharm Group", "国药控股股份有限公司"@zh ;
    obo:IAO_0000119 "http://www.sinopharm.com/1156.html", "https://en.wikipedia.org/wiki/Sinopharm_Group" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Sinopharm Group Co., Ltd."@en .

obo:VO_0004951
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "http://www.wibp.com.cn" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Wuhan Institute of Biological Products"@en .

obo:VO_0004952
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Gamaleya_Research_Institute_of_Epidemiology_and_Microbiology", "https://gamaleya.org/en/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Gamaleya Research Institute"@en .

obo:VO_0004953
    obo:IAO_0000117 "Philip, Oliver" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Moderna", "https://www.modernatx.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Moderna"@en .

obo:VO_0004954
    obo:IAO_0000115 "A biopharmaceutical company headquartered in Beijing, China" ;
    obo:IAO_0000118 "Sinovac" ;
    obo:IAO_0000119 "http://www.sinovac.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Sinovac Biotech Ltd"@en .

obo:VO_0004955
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.anges.co.jp/en/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "AnGes, Inc."@en .

obo:VO_0004956
    obo:IAO_0000115 "An American biotech company focused on the discovery, development and commercialization of therapeutics for rare diseases with focus on RNA" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Arcturus_Therapeutics" ;
    oboInOwl:hasURI "arcturusrx.com" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Arcturus Therapeutics"@en .

obo:VO_0004957
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "http://en.biominhai.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Beijing Minhai Biotechnology Co., Ltd."@en .

obo:VO_0004958
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    oboInOwl:hasURI "https://vaxxinity.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Vaxxinity"@en .

obo:VO_0004959
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "http://www.ystwt.cn/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Beijing Wantai Biological Pharmacy"@en .

obo:VO_0004960
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "FBRI SRC VB VECTOR", "Federal Budgetary Research Institution State Research Center of Virology and Biotechnology", "Vector Institute" ;
    oboInOwl:hasURI "http://www.vector.nsc.ru/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "State Research Center of Virology and Biotechnology VECTOR"@en .

obo:VO_0004961
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "http://www.genexine.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Genexine, Inc."@en .

obo:VO_0004962
    obo:IAO_0000115 "An American biotechnology company focused on the discovery, development, and commercialization of synthetic DNA products for treating cancers and infectious diseases" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Inovio_Pharmaceuticals" ;
    oboInOwl:hasURI "https://www.inovio.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Inovio Pharmaceuticals, Inc."@en .

obo:VO_0004963
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://kentuckybioprocessing.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Kentucky Bioprocessing, Inc."@en .

obo:VO_0004964
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Anhui Zhifei Longcom Biopharmaceutical Co., Ltd."@en .

obo:VO_0004965
    obo:IAO_0000115 "A manufacturer of immunobiological drugs including vaccines in India" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Serum_Institute_of_India" ;
    oboInOwl:hasURI "https://www.seruminstitute.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Serum Institute of India"@en .

obo:VO_0004966
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://zyduscadila.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Zydus Cadila"@en .

obo:VO_0004967
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "http://www.adimmune.com.tw/en/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Adimmune Corporation"@en .

obo:VO_0004968
    obo:IAO_0000115 "A China-based company principally engaged in the research, development, production and distribution of vaccines, monoclonal antibodies and blood products" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://www.reuters.com/companies/300142.SZ" ;
    oboInOwl:hasURI "http://www.walvax.com/wosen/27.aspx" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Walvax Biotechnology Co., Ltd."@en .

obo:VO_0004969
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.symvivo.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Symvivo"@en .

obo:VO_0004970
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.chula.ac.th/en/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Chulalongkorn University"@en .

obo:VO_0004971
    obo:IAO_0000115 "A public research university in London" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Imperial_College_London" ;
    oboInOwl:hasURI "https://www.imperial.ac.uk/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Imperial College London"@en .

obo:VO_0004972
    obo:IAO_0000115 "A Canadian biotechnology company focused on the discovery, development, and commercialization of virus-like particles using plants as \"bioreactors\" to produce proteins as candidate vaccines and medications" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Medicago_Inc." ;
    oboInOwl:hasURI "https://www.medicago.com/en/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Medicago Inc."@en .

obo:VO_0004973
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.entospharma.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Entos Pharmaceuticals"@en .

obo:VO_0004974
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.reithera.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "ReiThera Srl"@en .

obo:VO_0004975
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://immunitybio.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "ImmunityBio, Inc."@en .

obo:VO_0004976
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://nantkwest.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "NantKwest, Inc."@en .

obo:VO_0004977
    obo:IAO_0000115 "The teaching hospital of the University of Hamburg and one of the largest hospitals in Hamburg, Germany" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/University_Medical_Center_Hamburg-Eppendorf" ;
    oboInOwl:hasURI "https://www.uke.de/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "University Medical Center Hamburg-Eppendorf"@en .

obo:VO_0004978
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://medigen-usa.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Medigen, Inc."@en .

obo:VO_0004979
    obo:IAO_0000115 "A public research university in Chengdu, Sichuan, China" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "四川大学"@pt ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Sichuan_University" ;
    oboInOwl:hasURI "http://en.scu.edu.cn/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Sichuan University"@en .

obo:VO_0004980
    obo:IAO_0000117 "Philip Huang"@pt ;
    oboInOwl:hasURI "https://vaxine.net/"@pt ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Vaxine Pty Ltd."@en .

obo:VO_0004981
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.finlay.edu.cu/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Instituto Finlay de Vacunas"@en .

obo:VO_0004982
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "www.cloverbiopharma.com" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Clover Biopharmaceuticals, Inc."@en .

obo:VO_0004983
    obo:IAO_0000115 "A French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "Pasteur Institute" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Pasteur_Institute" ;
    oboInOwl:hasURI "https://www.pasteur.fr/en" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Institut Pasteur" .

obo:VO_0004984
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.covaxx.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "COVAXX"@en .

obo:VO_0004985
    obo:IAO_0000115 "A public research university located primarily in Brisbane, Queensland, Australia" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/University_of_Queensland" ;
    oboInOwl:hasURI "https://www.uq.edu.au/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "University of Queensland"@en .

obo:VO_0004986
    obo:IAO_0000115 "An American biotechnology company focused on the discovery, development, and commercialization of oral recombinant vaccines" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Vaxart" ;
    oboInOwl:hasURI "https://vaxart.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Vaxart, Inc."@en .

obo:VO_0004987
    obo:IAO_0000115 "A SARS-CoV-2 RNA vaccine formed from a lipid nanoparticle-formulated trimerized SARS-CoV-2 receptor-binding domain" ;
    obo:IAO_0000117 "Philip Huang, Rohit Goru, Oliver He" ;
    obo:IAO_0000118 "BNT162b2"@en, "PF-07302048", "Tozinameran" ;
    obo:IAO_0000119 "PubMed: 32839784", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php", "https://en.wikipedia.org/wiki/Tozinameran", "https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/Pfizer-BioNTech.html", "https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/pfizer-biontech-covid-19-vaccine", "https://www.fda.gov/media/144246/download" ;
    a owl:Class ;
    rdfs:label "Comirnaty" ;
    rdfs:subClassOf obo:VO_0005265, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004947 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004988
    obo:IAO_0000117 "Oliver He, Philip Huang" ;
    a owl:Class ;
    rdfs:label "SARS-CoV-2 protein"@en ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0004989
    obo:IAO_0000116 "Replaced term with S protein of SARS-CoV-2 Wuhan strain (PR_P0DTC2) for ontology harmonization" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "S protein of SARS-CoV-2"@en ;
    owl:deprecated true .

obo:VO_0004990
    a owl:Class ;
    rdfs:label "E protein of SARS-CoV-2"@en ;
    rdfs:subClassOf obo:VO_0004988 .

obo:VO_0004991
    obo:IAO_0000115 "BBV152 (also known as Covaxin) is an inactivated COVID-19 vaccine that is developed by Bharat Biotech in collaboration with the Indian Council of Medical Research." ;
    obo:IAO_0000117 "Philip Huang, Rohit Guru, Oliver He" ;
    obo:IAO_0000118 "BBV152" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php", "https://en.wikipedia.org/wiki/BBV152", "https://go.drugbank.com/drugs/DB15847" ;
    a owl:Class ;
    rdfs:label "COVAXIN"@en ;
    rdfs:subClassOf obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0004992
    obo:IAO_0000115 "A recombinant coronavirus-like particle SARS-CoV-2 vaccine developed by Medicago" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04636697" ;
    a owl:Class ;
    rdfs:label "CoVLP"@en ;
    rdfs:subClassOf obo:VO_0005205, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0001320
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0004993
    obo:IAO_0000115 "A P. falciparum malaria vaccine that is formed by tull length CS-expressing replication-deficient recombinant human adenovirus 35." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "PMID:18455276" ;
    a owl:Class ;
    rdfs:comment "This is a term requested by Randi for the HIPC/ImmPort work" ;
    rdfs:label "Ad35.CS.01 malaria vaccine"@en ;
    rdfs:subClassOf obo:VO_0000087 .

obo:VO_0004994
    obo:IAO_0000115 "A SARS-CoV-2 trimeric S protein subunit vaccine." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04405908" ;
    a owl:Class ;
    rdfs:label "SCB-2019"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003153 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004982 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004995
    obo:IAO_0000115 "A SARS-CoV-2 S1-RBD-protein based vaccine developed by Vaxxinity" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04545749" ;
    a owl:Class ;
    rdfs:label "UB-612"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004958 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004996
    obo:IAO_0000115 "A SARS-CoV-2 replication-defective human adenovirus type 5/35 vector based vaccine expressing the S protein." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04666012" ;
    a owl:Class ;
    rdfs:label "AdCLD-CoV19"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004997 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0004997
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "http://www.cellid.co.kr/eng/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Cellid Co., Ltd."@en .

obo:VO_0004998
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://www.umcg.nl/EN/corporate/The_University_Medical_Center/Paginas/default.aspx" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "University Medical Center Groningen"@en .

obo:VO_0004999
    obo:IAO_0000115 "A SARS-CoV-2-RBD-Fc fusion protein designed to induce or boost a Th1/Th2 mixed immune response in patients against the Receptor Binding Domain (RBD) of the novel coronavirus spike protein." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://www.akstonbio.com/programs/covid-19-vaccine/" ;
    a owl:Class ;
    rdfs:label "AKS-452"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004998 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0005000
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCAGGSP7. This plasmid has a polylinker containing KpnI, XhoI, ClaI, EcoRV, SmaI, Not1 and Sac1 sites inserted into the EcoRI site of pCAGGS." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCAGGSP7 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID:9711802" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005001
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCAGGS/MCS.  This plasmid has a chicken beta-actin promoter, contains a multiple cloning site between the EcoRI and BglII sites of the rabbit beta-globin gene, and has restriction sites for the enzymes SacI, ClaI, NsiI, Asp718, SmaI, SphI, XhoI, and NheI." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCAGGS/MCS DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 9261394" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005002
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pWRG.  This plasmid is a eukaryotic expression plasmid that contains the immediate early promoter and intron A of human cytomegalovirus." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pWRG DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 10403592" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005003
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pHW2000.  This plasmid is derived from pHW12 and contains part of the human pol I promoter and murine terminator sequences, a CMV promoter, and the polyadenylation signal of the gene encoding bovine growth hormone." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pHW2000 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 10662626" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005004
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMV/R. This plasmid is a mammalian expression vector with a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCMV/R DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 20660192" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005005
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label VRC-9123." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "This plasmid was prepared under Good Manufacturing Practices at 4 mg/mL in phosphate buffered saline (PBS)." ;
    rdfs:label "VRC-9123 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 21975270" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005006
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pPJV7563.  This plasmid has a human cytomegalovirus immediate early promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pPJV7563 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 20544035" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005007
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label p188.  This plasmid is a replication-defective derivative of pP1/H7." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "p188 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 8212843" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005008
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label VR10551.  This plasmid contains a human cytomegalovirus immediate early 1 promoter, a kanamycin resistance gene, intron A and a modified rabbit b-globin terminator." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "VR10551 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 17637571" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005009
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label VCL-1632.  This plasmid contains a CMV promoter, kanamycin resistance gene, the murine κ constant region sequence, a translational enhancer, the murine IgG2a heavy-chain sequence, and a translation terminator.  This plasmid is derived from pUC-18." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "VCL-1632 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12384547" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005010
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSport-B-gal.  This plasmid contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pSport-B-gal DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12496961" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005011
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSin-B-gal.  This plasmid contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pSin-B-gal DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 10646851" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005012
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pLXSHD.  This plasmid has a murine leukemia virus enhancer-promoter LTR." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pLXSHD DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 7533183" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005013
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label WRG/BEN.  This plasmid is based off of pWRG7077.  It contains a CMV promoter and a kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "WRG/BEN DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 9739060" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005014
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pNGVL4a.  This plasmid has a CMV promoter and kanamycin and ampicillin resistance genes." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "There is an extra immunostimulatory sequence (450 bp) in pNGVL4a plasmid compared to pNGVL3" ;
    rdfs:label "pNGVL4a DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 11818167" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005015
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pNGVL3.  This plasmid has a CMV promoter and kanamycin and ampicillin resistance genes." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pNGVL3 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 11818167" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005016
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label SINCp B-gal.  This plasmid contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "SINCp B-gal DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 17024104" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005017
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label Synchotrope TA2M.  This plasmid is 3683 base pairs in length and has two copies of the murine CpG immune stimulatory sequence AACGTT inserted." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "It has been shown that plasmid half-life in human serum in vitro is 20 minutes" ;
    rdfs:label "Synchotrope TA2M DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12833467" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005018
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMV/myc/ER.  This plasmid is 5066 base pairs in length and contains a CMV promoter and ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2236/" ;
    a owl:Class ;
    rdfs:label "pCMV/myc/ER DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005019
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pPA63-LAMP1." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pPA63-LAMP1 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 19130551" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005020
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSecTag2B.  This plasmid is 5163 base pairs in length and contains a CMV promoter and ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Invitrogen:http://tools.invitrogen.com/content/sfs/manuals/psectag2_man.pdf; Sequence: http://tools.invitrogen.com/content/sfs/vectors/psectag2b_seq.txt" ;
    a owl:Class ;
    rdfs:label "pSecTag2B DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005021
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pTPA-PA63-LAMP1." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pTPA-PA63-LAMP1 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 19130551" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005022
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pTPA-PA63." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pTPA-PA63 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 19130551" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005023
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label VR2210.  This plasmid contains a CMV promoter and kanamycin resistance gene.  It was created through ligation of fragments of digested plasmid VR1012, hTPA, and B. burgdorferi B31 ospA." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "VR2210 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 8985201" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005024
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMV-TPA/ZS7.  This plasmid contains a CMV promoter and is generated from pCMV-ZS7 by attaching hTPA to ospC ZS7." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCMV-TPA/ZS7 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12941385; PMID: 10580194" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005025
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pABB-CRS2.  This plasmid is a derivative of pCVD442 and contains a chloramphenicol resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pABB-CRS2 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 11562461" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005026
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pMASIA-tgD.  This plasmid is based off of pMASIA and contains a CMV promoter and kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pMASIA-tgD DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12466473" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005027
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMVi-UB.  This plasmid was built from pCMV-5 and contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCMVi-UB DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 10433551" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005028
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCI30.  This plasmid contains a CMV promoter, ampicillin resistance gene, T7 RNA polymerase promoter, a multiple cloning region and a 6xHis tag coding sequence." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCI30 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 17239501; PMID: 11567754" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005029
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCP15/60." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCP15/60 DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005030
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pUMVC3.  This plasmid is 4030 base pairs in length and contains a CMV promoter and kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Aldevron: http://www.aldevron.com/products/dnas/umvc_expression/" ;
    a owl:Class ;
    rdfs:label "pUMVC3 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12654810" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005031
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pcDNA1.  This plasmid is 4000 base pairs in length and contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: https://www.addgene.org/vector-database/2089/" ;
    a owl:Class ;
    rdfs:label "pcDNA1 DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005032
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCAT.  This plasmid is 4364 base pairs in length and contains an ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2051/" ;
    a owl:Class ;
    rdfs:label "pCAT DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005033
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pGT36.  This plasmid is a derivative of pcDNA3 and contains a CMV promoter and a kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pGT36 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 9569471]" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005034
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label VR1040.  This plasmid contains four copies of the mouse immunostimulatory sequence and is similar to VR1012." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "VR1040 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 11883007" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005035
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pcTPA.  This plasmid is based on pcDNA3 and contains the hTPA signal sequence." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pcTPA DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 16122850" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005036
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pMV10.1.  This plasmid contains a CMV promoter and a kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pMV10.1 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 16125280" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005037
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pET11d.  This plasmid is 5674 base pairs in length and contains an ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2628/" ;
    a owl:Class ;
    rdfs:label "pET11d DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 16520093" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005038
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pUMVC4b.  This plasmid is 4478 base pairs in length and contains a CMV promoter and kanamycin and ampicillin resistance genes." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Aldevron: http://www.aldevron.com/products/dnas/umvc_expression/; Sequence: https://system.netsuite.com/c.606687/pUMVC4a.txt" ;
    a owl:Class ;
    rdfs:label "pUMVC4b DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005039
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pRC.  This plasmid is 7400 base pairs in length and contains CMV and RSV promoters." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pRC DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 9879611" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005040
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pAK-4.  This plasmid is 6600 base pairs in length and contains a CMV promoter and kanamycin and ampicillin resistance genes." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pAK-4 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 16157425" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005041
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMVi(-H3)Ubs.  This plasmid contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCMVi(-H3)Ubs DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 10438054" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005042
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label Auxo-GTU." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "patent applications, PCT/FI02/00379 filed 03.05.2002 and PCT/FI2004/ 000540 filed 15.09.2004" ;
    rdfs:label "Auxo-GTU DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 16359234" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005043
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMN160.  This plasmid has a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCMN160 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 9142121" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005044
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label V1Jns.  This plasmid contains the human CMV promoter, enhancer and intron A as well as the polyadenylation sequences of bovine growth hormone." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "V1Jns DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 9127013" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005045
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pND-14.  This plasmid contains a CMV promoter, ampicillin resistance gene, a tissue plasminogen activator leader sequence, a bovine growth hormone terminator, and constitutive transport element from simian retrovirus." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pND-14 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 15149785" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005046
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSecTag2A.  This plasmid is 5159 base pairs in length and contains a CMV promoter and ampicillin reisistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Invitrogen: http://tools.invitrogen.com/content/sfs/manuals/psectag2_man.pdf; Sequence: http://tools.invitrogen.com/content/sfs/vectors/psectag2a_seq.txt" ;
    a owl:Class ;
    rdfs:label "pSecTag2A DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005047
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pRc/CMV-HBs(S).  This plasmid is 5618 base pairs in length and contains a CMV promoter and ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Bioresearch Online: http://www.bioresearchonline.com/doc/pRcCMV-HBsS-0001" ;
    a owl:Class ;
    rdfs:comment "Also known as pCMV-S" ;
    rdfs:label "pRc/CMV-HBs(S) DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005048
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pcDNA." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pcDNA DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 15839423" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005049
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label proVAX.  This plasmid contains a CMV promoter and a hCG-β leader sequence." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "proVAX DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 17310492" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005050
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label p1012." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "p1012 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 11117750" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005051
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pUSE-.  This plasmid is a mammalian expression vector derived from pCI-neo." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pUSE- DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 11507187" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005052
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label APL023." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "APL023 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 17241713" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005053
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pEGFP-N1.  This plasmid is 4733 base pairs in length and contains a CMV promoter and kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2491/" ;
    a owl:Class ;
    rdfs:label "pEGFP-N1 DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005054
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCDL-SRa296.  This plasmid is 3700 base pairs in length and contains a SRalpha promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2084/" ;
    a owl:Class ;
    rdfs:label "pCDL-SRa296 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 2827008" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005055
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pUSK." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pUSK DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 15121294" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005056
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pUBIQ.  This plasmid is derived from pGEM3 and contains a CMV promoter and an ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pUBIQ DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12922097" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005057
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pcDNA3.1/Hygro(-).  This plasmid is 5596 base pairs in length and contains a CMV promoter and an ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2105/" ;
    a owl:Class ;
    rdfs:comment "Differs from other pcDNA3.1 in drug resistance; +/- refers to orientation of f1 ori" ;
    rdfs:label "pcDNA3.1/Hygro(-) DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005058
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMV3ISS.  This plasmid is a eukaryotic expression vector." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCMV3ISS DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 18951941" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005059
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pWRG7079.  This plasmid contains a CMV promoter and a kanamycin resistance gene and differs from pWRG7077 by the insertion of a TPA sequence." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pWRG7079 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 12922144" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005060
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pVR1020.  This plasmid contains a CMV promoter and kanamycin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pVR1020 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 11292786" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005061
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label nkCMVintpolyli.  This plasmid contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "nkCMVintpolyli DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 8666931" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005062
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pcDNA3.1/V5-His-TOPO.  This plasmid is 5523 base pairs in length and contains a CMV promoter and ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/5587/" ;
    a owl:Class ;
    rdfs:label "pcDNA3.1/V5-His-TOPO DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005063
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pIRES1neo.  This plasmid is 5257 base pairs in length and contains an ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Metalife: http://www.metalife.com/Genbank/1899169" ;
    a owl:Class ;
    rdfs:label "pIRES1neo DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005064
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pRc/RSV.  This plasmid is 5224 base pairs in length and contains a RSV LTR promoter and ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/3908/" ;
    a owl:Class ;
    rdfs:label "pRc/RSV DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005065
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCI-TPA.  This plasmid contains the N-terminal signal sequence of TPA." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCI-TPA DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 19428891" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005066
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCSIVgag." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pCSIVgag DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 18000037" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005067
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pVacc4.  This plasmid is a derivative of pVacc1 and contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pVacc4 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 15004179" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005068
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pBC12B1.  This plasmid is a eukaryotic expression vector." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pBC12B1 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 10948115" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005069
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pGFP.  This plasmid is 3300 base pairs in length and contains a lac promoter and an ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Clontech: http://www.clontech.com/xxclt_ibcGetAttachment.jsp?cItemId=17740" ;
    a owl:Class ;
    rdfs:label "pGFP DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005070
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pCMV-beta.  This plasmid is 7164 base pairs in length and contains a CMV promoter and ampicllin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2245/" ;
    a owl:Class ;
    rdfs:label "pCMV-beta DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005071
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pSW3891.  This plasmid contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pSW3891 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 16919703" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005072
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pJW4304.  This plasmid is 5132 base pairs in length and contains a CMV promoter." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "NIH AIDS Reagent Program: https://www.aidsreagent.org/reagentdetail.cfm?t=cloning_vectors&id=76" ;
    a owl:Class ;
    rdfs:label "pJW4304 DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005073
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pGT146-mIL-12." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pGT146-mIL-12 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 18694965" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005074
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pDNAVACC." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pDNAVACC DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 21134447" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005075
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label VR1055.  This plasmid is derived from pUC19 and contains a CMV promoter, kanamycin resistance gene, a cloning polylinker, and a transcriptional terminator region derived from the rabbit beta-globin gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "VR1055 DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 9990062" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005076
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pRSC." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:label "pRSC DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 21185849" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005077
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pcDNA3.1(Zeo)+.  This plasmid is 5015 base pairs in length and contains a zeocin selectable marker, a CMV promoter, and an ampicillin resistance gene." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    obo:IAO_0000119 "Addgene: http://www.addgene.org/vector-database/2110/" ;
    a owl:Class ;
    rdfs:label "pcDNA3.1(Zeo)+ DNA vaccine plasmid" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005078
    obo:IAO_0000115 "A DNA vaccine plasmid vector that has the plasmid label pVF." ;
    obo:IAO_0000117 "Rebecca Racz, Yongqun He" ;
    a owl:Class ;
    rdfs:comment "Also known as pVAX-Flag" ;
    rdfs:label "pVF DNA vaccine plasmid" ;
    rdfs:seeAlso "PMID: 23026687" ;
    rdfs:subClassOf obo:VO_0000435 .

obo:VO_0005079
    obo:IAO_0000115 "A SARS-CoV-2 vaccine consisting of autologous dendritic cells previously loaded ex vivo with spike protein." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04386252" ;
    a owl:Class ;
    rdfs:label "AV-COVID-19"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005080
    obo:IAO_0000117 "Philip Huang" ;
    oboInOwl:hasURI "https://aivitabiomedical.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "AIVITA Biomedical, Inc."@en .

obo:VO_0005081
    obo:IAO_0000115 "A SARS-CoV-2 vaccine that includes a protein antigen, SARS-CoV-2 Spike RBD, adsorbed to the adjuvant Alhydrogel (Alum), in combination with another approved adjuvant, CpG 1018" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://www.biologicale.com/news.html" ;
    a owl:Class ;
    rdfs:label "BECOV2A"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005082
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine based on recombinant RBD subunits manufactured by the Center for Genetic Engineering and Biotechnology (CIGB)." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "CIGB-66" ;
    obo:IAO_0000119 "https://rpcec.sld.cu/en/trials/RPCEC00000345-En" ;
    a owl:Class ;
    rdfs:label "Abdala"@en ;
    rdfs:subClassOf obo:VO_0005202, obo:VO_0005269, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005083
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine based on recombinant RBD subunits manufactured by the Center for Genetic Engineering and Biotechnology (CIGB)." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://rpcec.sld.cu/en/trials/RPCEC00000345-En" ;
    a owl:Class ;
    rdfs:label "CIGB-669"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005084
    obo:IAO_0000115 "A SARS-CoV-2 inactivated virus vaccine by Shenzhen Kangtai Biological Products and Beijing Minhai Biotechnology Co."@en ;
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "NCT04852705", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "KCONVAC" ;
    rdfs:subClassOf obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005085
    obo:IAO_0000115 "A stabilised pre-fusion SARS-CoV-2 spike protein vaccine produced in a baculovirus expression system and manufactured by Sanofi Pasteur and GlaxoSmithKline" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "CoV2 preS dTM" ;
    obo:IAO_0000119 "PubMed ID: 33887209" ;
    a owl:Class ;
    rdfs:label "VAT00002"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0005086
    obo:IAO_0000115 "Sanofi S.A. is a French multinational pharmaceutical company headquartered in Paris, France." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Sanofi" ;
    oboInOwl:hasURI "https://www.sanofi.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Sanofi S.A."@en .

obo:VO_0005087
    obo:IAO_0000115 "An influenza virus vector SARS-CoV-2 vaccine administered as an intranasal spray manufactured by University of Hong Kong, Xiamen University, and Beijing Wantai Biological Pharmacy." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "http://www.chictr.org.cn/showprojen.aspx?proj=55421" ;
    a owl:Class ;
    rdfs:label "DelNS1-2019-nCoV-RBD-OPT1"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005088
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine that relies on chemically synthesized peptide antigens of SARS-CoV-2 proteins, conjugated to a carrier protein and adsorbed on an aluminum-containing adjuvant (aluminum hydroxide)." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04527575", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "EpiVacCorona"@en ;
    rdfs:subClassOf obo:VO_0005269, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005089
    obo:IAO_0000115 "A SARS-CoV-2 plasmid DNA vaccine developed by GeneOne Life Science." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04673149" ;
    a owl:Class ;
    rdfs:label "GLS-5310"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005090
    obo:IAO_0000115 "A rVSV-SARS-CoV-2-S vaccine developed by the Israel Institute for Biological Research (IIBR)" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "Brilife" ;
    obo:IAO_0000119 "NCT04608305" ;
    a owl:Class ;
    rdfs:label "IIBR-100"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005091
    obo:IAO_0000115 "A SARS-CoV-2 recombinant vector vaccine by Shenzhen Geno-Immune Medical Institute" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04276896" ;
    a owl:Class ;
    rdfs:label "LV-SMENP-DC"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005092
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine with recombinant SARS-CoV-2 spike (S) protein and aluminum phosphate adjuvant" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04683484" ;
    a owl:Class ;
    rdfs:label "Nanocovax"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000128
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005093
    obo:IAO_0000115 "A SARS-CoV-2 inactivated vaccine manufactured by the Research Institute for Biological Safety Problems (Republic of Kazakhstan)" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "QazCovid-in"@en ;
    obo:IAO_0000119 "NCT04691908", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "QazVac" ;
    rdfs:subClassOf obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005094
    obo:IAO_0000115 "A SARS-CoV-2 virus-like particle vaccine that contains the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike (S) protein and is adjuvanted with aluminum." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "ACTRN12620001308987" ;
    a owl:Class ;
    rdfs:label "RBD-HBsAg VLP"@en ;
    rdfs:subClassOf obo:VO_0005205, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:VO_0004989
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005095
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine by West China Hospital" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04640402" ;
    a owl:Class ;
    rdfs:label "Recombinant SARS-CoV-2 vaccine (Sf9 cell)"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005096
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "A SARS-CoV-2 recombinant protein vaccine that uses the Baculovirus expression vector system", "https://www.shionogi.com/content/dam/shionogi/global/news/pdf/2020/12/e-201216.pdf" ;
    a owl:Class ;
    rdfs:label "S-268019"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005097
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine developed by Finlay Vaccine Institute (IFV)" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "FINLAY-FR-2"@en ;
    obo:IAO_0000119 "https://rpcec.sld.cu/en/trials/RPCEC00000347-En" ;
    a owl:Class ;
    rdfs:label "Soberana 02" ;
    rdfs:subClassOf obo:VO_0005202, obo:VO_0005269, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005098
    obo:IAO_0000115 "A SARS-CoV-2 vaccine candidate that uses a measles virus vector platform, and is made by Merck. Development of the vaccine was discontinued on January 25, 2021." ;
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "https://www.merck.com/news/merck-discontinues-development-of-sars-cov-2-covid-19-vaccine-candidates-continues-development-of-two-investigational-therapeutic-candidates/" ;
    a owl:Class ;
    rdfs:label "V591"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005099
    obo:IAO_0000115 "A SARS-CoV-2 inactivated, Vero-cell based vaccine adjuvanted with aluminum and CpG 1018. It uses the manufacturing platform of Valneva’s commercial Japanese encephalitis (JE) vaccine" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://valneva.com/research-development/covid-19-vla2001/" ;
    a owl:Class ;
    rdfs:label "VLA2001"@en ;
    rdfs:subClassOf obo:VO_0005201, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0003154
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005100
    obo:IAO_0000115 "'A SARS DNA vaccine that is made from recombinant plasmid containing nucleocapsid protein (N) sequence constructed then expressed and purified from E. coli bacteria’" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5732" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:16423399" ;
    rdfs:label "SARS N protein DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5732" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005101
    obo:IAO_0000115 "'A SARS DNA combination vaccine that is made from recombinant plasmids’ containing membrane protein (M) and nucleocapsid protein (N) sequences constructed then expressed and purified from E. coli bacteria’" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5733" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:16423399" ;
    rdfs:label "SARS N + SARS M DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5733" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005102
    obo:IAO_0000115 "'A SARS  DNA vaccine that is made from recombinant plasmid containing membrane protein (M) sequence constructed then expressed and purified from E. coli bacteria’" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5731" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:16423399" ;
    rdfs:label "SARS M protein DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5731" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005103
    obo:IAO_0000115 "'A SARS DNA vaccine that is made from  oral live-attenuated auxotrophic S. typhimurium aroA strain SL7207 that contained CTLA4HingeSARS800 with SARS-CoV S protein‘" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5738" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15993989" ;
    rdfs:label "Salmonella-CTLA4-S SARS DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5738" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005104
    obo:IAO_0000115 "A SARS DNA vaccine that is made from  intraperitoneal recombinant spike polypeptide generated by amplififying gene encoding amino acids residues 14-667 of S protein that was cloned BamHI and KpnI sites of vector pQE-31 that was generated by Escherichia coli" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5734" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15993989" ;
    rdfs:label "Recombinant SARS spike polypeptide vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5734" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000623
    ] .

obo:VO_0005105
    obo:IAO_0000115 "A SARS DNA vaccine that is made from  CTLA4HingeSARS800 DNA with SARS-CoV S protein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5737" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15993989" ;
    rdfs:label "SARS CTLA4-S DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5737" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005106
    obo:IAO_0000115 "A SARS DNA vaccine that is made from tpa-optimize800 DNA with SARS-CoV S protein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5736" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15993989" ;
    rdfs:label "SARS tPA-S DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5736" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005107
    obo:IAO_0000115 "A SARS DNA vaccine made from  CTLA4HingeSARS800 DNA with SARS-CoV S protein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5739" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15993989" ;
    rdfs:label "Salmonella-tPA-S SARS DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5739" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005108
    obo:IAO_0000115 "A SARS recombinant vector vaccine that is made  from of the highly attenuated modified vaccinia virus Ankara (MVA) containing the gene encoding full-length SARS-CoV S" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5729" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:23142821" ;
    rdfs:label "SARS MA-ExoN vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5729" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005109
    obo:IAO_0000115 "A SARS recombinant vector vaccine that is made from  recombinant MA15 virulent mouse-adapted SARS-CoV (MA15) background of E-deleted vaccine candidate (rMA15-ΔE)" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5728" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:16423399" ;
    rdfs:label "SARS rMA15-ΔE vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5728" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005110
    obo:IAO_0000115 "A SARS recombinant vector vaccine that is made from a recombinant live-attenuated modified vaccinia virus Ankara (MVA) that had a full-length SARS-CoV envelope Spike (S) glycoprotein gene introduced into the deletion III region of the MVA genome." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5726" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15708987" ;
    rdfs:label "SARS ADS-MVA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5726" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005111
    obo:IAO_0000115 "A MERS subunit vaccine that has a combined adjuvant of aluminum hydroxide and CpG oligodeoxynucleotides." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5714" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:29618723" ;
    rdfs:label "MERS-CoV S vaccine adjuvanted with CpG and Alum" ;
    rdfs:seeAlso "VIOLIN ID: 5714" ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000127
    ] .

obo:VO_0005112
    obo:IAO_0000115 "A MERS inactivated whole virus vaccine that has a combined adjuvant that has a combined adjuvant of aluminum hydroxide and CpG oligodeoxynucleotides." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5721" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:29618723" ;
    rdfs:label "Inactivated whole MERS-CoV (IV) vaccine with CpG and Alum" ;
    rdfs:seeAlso "VIOLIN ID: 5721" ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_1335626
    ] .

obo:VO_0005113
    obo:IAO_0000115 "A SARS recombinant vector vaccine made from a recombinant form of the highly attenuated modified vaccinia virus Ankara (MVA) containing the gene encoding full-length SARS-CoV S" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5725" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15096611" ;
    rdfs:label "SARS MVA/S vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5725" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005114
    obo:IAO_0000115 "A SARS inactivated vaccine made from whole killed (inactivated by beta-propiolactone) SARS-CoV" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5730" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:16476986" ;
    rdfs:label "β-propiolactone-inactivated SARS-CoV vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5730" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0005115
    obo:IAO_0000115 "A SARS recombinant vector vaccine made of combination of two adenovirus-based vectors, one expressing the nucleocapsid (N) and the other expressing the spike (S) protein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5727" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:16476986" ;
    rdfs:label "SARS Ad S/N vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5727" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005116
    obo:IAO_0000115 "A MERS recombinant vector vaccine made of a recombinant adenoviral vector encoding the  the S1 extracellular domain of S protein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5719" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:25192975" ;
    rdfs:label "Ad5.MERS-S1 vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5719" ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0001081
    ] .

obo:VO_0005117
    obo:IAO_0000115 "A MERS recombinant vector vaccine made of a recombinant adenoviral vector encoding the full-length MERS-CoV S protein (Ad5.MERS-S)" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5720" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:25192975" ;
    rdfs:label "Ad5.MERS-S vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5720" ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0001081
    ] .

obo:VO_0005118
    obo:IAO_0000115 "A MERS DNA vaccine made of plasmid  that encoded S1 subunit only" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5715" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26218507" ;
    rdfs:label "MERS England1 S1 protein subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5715" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005119
    obo:IAO_0000115 "A MERS combination vaccine made of made of the VRC8400 plasmid that encodes the full-length, membrane anchore MERS spike protein and a DNA vaccine that is a plasmid  that encoded S1 subunit" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5717" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26218507" ;
    rdfs:label "MERS England1 S DNA + England1 S protein subunit vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5717" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005120
    obo:IAO_0000115 "A MERS DNA vaccine made of the VRC8400 plasmid that encodes the full-length, membrane anchore MERS spike protein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5716" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26218507" ;
    rdfs:label "MERS England1 S DNA Vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5716" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005121
    obo:IAO_0000115 "A MERS subunit vaccine made of neutralizing monoclonal antibodiesagainst MERS-CoV which bind to the ribosomal binding domain (RBD) of the MERS-CoV S protein that was expressed by baculovirus-insect cell sf9-derived recombinant MERS-CoV." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5723" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:28536429" ;
    rdfs:label "MERS rRBD plus alum vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5723" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005122
    obo:IAO_0000115 "A MERS DNA vaccine made of plasmid that encodes the first 725 amino acids of S from MERS-CoV" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5718" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:28314561" ;
    rdfs:label "MERS-CoV pcDNA3.1-S1 DNA vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5718" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005123
    obo:IAO_0000115 "A MERS recombinant vector virus made from chimeric virus based on the vesicular stomatitis virus (VSV) in which the G gene was replaced by MERS-CoV S gene (VSVΔG-MERS)." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5722" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:29246504" ;
    rdfs:label "VSVΔG-MERS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5722" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005124
    obo:IAO_0000115 "A MERS subunit vaccine made of a neutralizing monoclonal antibodiesagainst MERS-CoV which bind to the N-terminal domain (NTD) of the MERS-CoV S1 subunit that was expressed by baculovirus-insect cell sf9-derived recombinant MERS-CoV." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5724" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:28536429" ;
    rdfs:label "MERS rNTD vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5724" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005125
    obo:IAO_0000115 "A SARS inactivated vaccine made from inactivated whole virus by formalin and Ultraviolet radiation, hence Double Inactivated (DI) Vaccine" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5742" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:22536382" ;
    rdfs:label "inactivated whole (formalin and UV radiation) SARS-CoV vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5742" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0005126
    obo:IAO_0000115 "A SARS DNA vaccine made from rDNA-expressed ectodomain of the S protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5743" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:22536382" ;
    rdfs:label "recombinant SARS DNA spike protein vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5743" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000623
    ] .

obo:VO_0005127
    obo:IAO_0000115 "A SARS VLP vaccine made from the SARS-CoV spike protein (S) and the Nucleocapsid (N), envelope (E) and membrane (M) proteins from mouse hepatitis coronavirus (MHV)" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5747" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:22536382" ;
    rdfs:label "Viral-like-particle  S-MHV SARS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5747" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005128
    obo:IAO_0000115 "A SARS inactivated vaccine made from SARS-CoV inactivated by ultraviolet radiation and a Toll-Like Receptor Agonist Adjuvant is added to prevent eosinophilic immunopathology" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5741" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:22536382" ;
    rdfs:label "UV-Inactivated SARS + TLR agonist vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5741" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0005129
    obo:IAO_0000115 "A SARS inactivated vaccine made from SARS-CoV inactivated by ultraviolet radiation" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5740" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:22536382" ;
    rdfs:label "UV-Inactivated SARS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5740" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0005130
    obo:IAO_0000115 "A MERS recombinant vector made from Venezuelan equine encephalitis replicons bearing epitopes of N protein from MERS. Crosslisted as SARS vaccine (VIOLINID:5754). Efficacy higher intranasally than subcutaneously." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5748" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26954467" ;
    rdfs:label "VRP-MERS-N vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5748" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005131
    obo:IAO_0000115 "A SARS recombinant vector vaccine made from Venezuelan equine encephalitis replicons (VRP) encoding a SARS-CoV CD4+ T cell epitope vaccinated intranasally. Crosslisted as MERS vaccine (VIOLINID:5789). Efficacy higher intranasally than subcutaneously." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5749" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26954467" ;
    rdfs:label "VRP-SARS-N vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5749" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005132
    obo:IAO_0000115 "A MERS DNA vaccine made of plasmid vaccines that encoded S1 subunit only" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5750" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26954467" ;
    rdfs:label "rVV-SARS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5750" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005133
    obo:IAO_0000115 "A MERS recombinant vector vaccine made of live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike protein (MERS-S)." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5757" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26355094" ;
    rdfs:label "MVvac2-MERS-S(H) vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5757" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005134
    obo:IAO_0000115 "A MERS recombinant vector vaccine made of live-attenuated measles virus (MV) vaccine encoding the MERS-CoV nucleocapsid protein (MERS-N)." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5760" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:29902727" ;
    rdfs:label "MVvac2-MERS-N vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5760" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005135
    obo:IAO_0000115 "A MERS recombinant vector made of  Chimpanzee adenovirus Oxford 1 vector expressing S protein from MERS-CoV’" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5751" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:29263883" ;
    rdfs:label "ChAdOx1-MERS-S vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5751" ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005181
    ] .

obo:VO_0005136
    obo:IAO_0000115 "A MERS recombinant vector made of Adenovirus type 41 used as vector for MERS-CoV S protein.’" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5760" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:25762305" ;
    rdfs:label "Ad41.MERS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5760" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005137
    obo:IAO_0000115 "A MERS VLP vaccine made from  a recombinant baculovirus co-expresssing the spike S, envelope (E), and membrane (M) proteins of MERS." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5758" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:23986586" ;
    rdfs:label "MVA-MERS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5758" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005138
    obo:IAO_0000115 "A SARS DNA vaccine made from  encoding calrectulin linked to a SARS-CoV N protein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5753" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:15078946" ;
    rdfs:label "CRT-N SARS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5753" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005139
    obo:IAO_0000115 "A SARS recombinant vector vaccine made from a line attenuated and recombinant SARS-CoV lacking the E gene" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=3155" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:18463152" ;
    rdfs:label "rSARS-CoV-ΔE vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 3155" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005140
    obo:IAO_0000115 "A MERS recombinant vector made of MVvac2 (measle virus) expressing a soluble, truncated version of spike glycoprotein of MERS-CoV in its full length cloned into the MVvac2 genome and rescued." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5759" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:26355094" ;
    rdfs:label "MVvac2-MERS-solS vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5759" ;
    rdfs:subClassOf obo:VO_0004900 .

obo:VO_0005141
    obo:IAO_0000115 "A SARS-CoV-2 whole virus vaccine made from a purified inactivated SARS-CoV-2 virus." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang, Rohit Goru, Oliver He" ;
    obo:IAO_0000118 "PiCoVacc" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5761", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php", "https://en.wikipedia.org/wiki/CoronaVac" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:32376603" ;
    rdfs:label "CoronaVac" ;
    rdfs:seeAlso "VIOLIN ID: 5761" ;
    rdfs:subClassOf obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_314146
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005142
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine composed of the SARS-CoV-2 S protein receptor-binding domain produced in Chinese hamster ovary (CHO) cells and adjuvant aluminum hydroxide." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5764", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "ZF2001" ;
    rdfs:seeAlso "VIOLIN ID: 5764" ;
    rdfs:subClassOf obo:VO_0005269, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005143
    obo:IAO_0000115 "A SARS-CoV-2 RNA vaccine made of self-coding RNA encoding SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5771" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:32647131" ;
    rdfs:label "LNP-nCoVsaRNA" ;
    rdfs:seeAlso "VIOLIN ID: 5771" ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000728
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005144
    obo:IAO_0000115 "A SARS-CoV-2 vaccine made from a recombinant adinvorius type-5 expressing SARS-CoV-2 S protein.", "A SARS-CoV-2 vaccine made of self-coding RNA encoding SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5768", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:32450106" ;
    rdfs:label "Ad5-nCoV" ;
    rdfs:seeAlso "VIOLIN ID: 5768" ;
    rdfs:subClassOf obo:VO_0005268, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000462 ;
        owl:someValuesFrom obo:VO_0000273
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0001081
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_314146
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005145
    obo:IAO_0000115 "A MERS DNA Vaccine that is made of the plasmid pGX9109 expressing MERS S protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5769" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:32450106" ;
    rdfs:label "MERS GLS-5300 vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5769" ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_314146
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1335626
    ] .

obo:VO_0005146
    obo:IAO_0000115 "A SARS DNA vaccine made of a single closed plasmid DNA marcromolecule (VRC-8138) that produces a deletion mutant of the SARS Spike glycoprotein" ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5770" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:18824060" ;
    rdfs:label "VRC-SRSDNA015-00-VP vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5770" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005147
    obo:IAO_0000115 "A SARS-CoV recombinant vector vaccine that is made from the Newcastle disease virus from the mesogenic Beaudette C strainexpressing SARS-CoV S protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5766" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:17535926" ;
    rdfs:label "SARS NDV-BC/S vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5766" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9534
    ] .

obo:VO_0005148
    obo:IAO_0000115 "A SARS-CoV recombinant vector vaccine that is made from the Newcastle disease virus from  the lentogenic LaSota strain expressing SARS-CoV S protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5767" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:17535926" ;
    rdfs:label "SARS NDV-VF/S vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5767" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9534
    ] .

obo:VO_0005149
    obo:IAO_0000115 "A SARS DNA vaccine made from rDNA-expressed ectodomain of the S protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5745" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:16497416" ;
    rdfs:label "rDNA-expressed S SARS protein vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5745" ;
    rdfs:subClassOf obo:VO_0012183 .

obo:VO_0005150
    obo:IAO_0000115 "A SARS DNA vaccine made up of arecombinat vector vaccine made from recombinant measles virus expressing S protein and recombinant measles virus expressing N protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5762" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:18346823" ;
    rdfs:label "rMV-S + rMV-N vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5762" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_5762
    ] .

obo:VO_0005151
    obo:IAO_0000115 "A SARS-CoV recombinant vector made from a baculovirus vector expressing SARS-CoV S protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5763" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:22536382" ;
    rdfs:label "SARS-CoV Baculovirus  S protein  Vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5763" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_5763
    ] .

obo:VO_0005152
    obo:IAO_0000115 "A MERS recombinant vector made of recombinant modified vaccinia virus Ankara (rMVA) vaccine vector carrying full MERS-CoV spike glycoprotein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "VIOLIN: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=5752" ;
    a owl:Class ;
    rdfs:comment "PubMed ID:32325037" ;
    rdfs:label "MVA-MERS-S vaccine" ;
    rdfs:seeAlso "VIOLIN ID: 5752" ;
    rdfs:subClassOf obo:VO_0004900, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005153
    obo:IAO_0000115 "A SARS-CoV-2 single dose intranasal vaccine manufactured by Altimmune in collaboration with the University of Alabama-Birmingham. This vaccine was discontinued after a Phase 1 trial." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://altimmune.com/adcovid/" ;
    a owl:Class ;
    rdfs:label "AdCOVID"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005154
    obo:IAO_0000115 "A plasmid pCI-N, encoding the full-length N gene of SARS-CoV, was constructed and expressed in Escherichia coli DH5alpha" ;
    obo:IAO_0000119 "[PubMed: 15582659]" ;
    a owl:Class ;
    rdfs:label "SARS-CoV pCI-N DNA vaccine"@en ;
    rdfs:seeAlso "VIOLIN ID: 5735" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_10090
    ] .

obo:VO_0005155
    obo:IAO_0000115 "A SARS-CoV 2 (rSARS-CoV-2) subunit vaccine made of nanoparticles composed of a trimeric full-length SARS-CoV-2 spike glycoprotein and Matrix-M1 adjuvant." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000118 "Covovax" ;
    obo:IAO_0000119 "PubMed:32376603" ;
    a owl:Class ;
    rdfs:label "NVX-CoV2373" ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0005206
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_314146
    ] .

obo:VO_0005156
    obo:IAO_0000115 "A SARS-CoV-2 RNA vaccine that has a lipid nanoparticle (LNP) platform and Spike protein antigen" ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "NCT04758962" ;
    a owl:Class ;
    rdfs:label "CoV2 SAM" ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005157
    obo:IAO_0000115 "A SARS-CoV2 RNA vaccine made of lipid nanoparticle with mRNA which encodes the S-2P antigen, made of the SARS-CoV-2 glycoprotein with a transmembrane anchor and intact S1-S2 cleavage site." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang, Rohit Goru, Oliver He" ;
    obo:IAO_0000118 "COVID-19 Vaccine Moderna", "CX-024414", "mRNA-1273" ;
    obo:IAO_0000119 "PubMed:32663912", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php", "https://en.wikipedia.org/wiki/MRNA-1273", "https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/Moderna.html", "https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/moderna-covid-19-vaccine" ;
    a owl:Class ;
    rdfs:label "Moderna COVID-19 vaccine" ;
    rdfs:subClassOf obo:VO_0005265, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005158
    obo:IAO_0000115 "A SARS-CoV2 recombinat vector vaccine made of a chimpanzee adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein" ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000118 "AZD1222", "COVID-19 Vaccine AstraZeneca", "ChAdOx1 nCoV-19" ;
    obo:IAO_0000119 "PubMed:32702298", "https://en.wikipedia.org/wiki/AZD1222" ;
    obo:VO_0003099 "Covishield" ;
    a owl:Class ;
    rdfs:label "Oxford–AstraZeneca COVID-19 vaccine" ;
    rdfs:seeAlso "violinID:2020-001072-15, 2020-001228-32, ISRCTN89951424" ;
    rdfs:subClassOf obo:VO_0005268, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000462 ;
        owl:someValuesFrom obo:VO_0000249
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005181
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005159
    obo:IAO_0000115 "A SARS-CoV-2 recombinant viral vector vaccine composed of Ad26 vector expressing S protein." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang, Oliver He" ;
    obo:IAO_0000118 "Ad26COVS1", "JNJ-78436735", "Johnson & Johnson COVID-19 vaccine" ;
    obo:IAO_0000119 "PubMed:32731257", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "Ad26.COV2.S" ;
    rdfs:subClassOf obo:VO_0005268, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0005178
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9526
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004932 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0005160
    obo:IAO_0000115 "A SARS-CoV-2 inactivated whole virus vaccine that is developed by the Wuhan Institute of Biological Products." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "PubMed:32789505", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "WIBP-CorV" ;
    rdfs:subClassOf obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005161
    obo:IAO_0000115 "A SARS-CoV-2 mRNA vaccine made of lipid nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 manufactured by Academy of Military Science (AMS), Walvax Biotechnology, and Suzhou Abogen Biosciences." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "PubMed:32795413" ;
    a owl:Class ;
    rdfs:label "ARCoV" ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005162
    obo:IAO_0000115 "A SARS-CoV-2 plasmid DNA vaccine that encodes the envelope protein." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "PubMed:32800805" ;
    a owl:Class ;
    rdfs:label "ZyCoV-D" ;
    rdfs:subClassOf obo:VO_0005323, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom <http://purl.obolibrary.org/obo/vo/ontorat/PR_P0DTC4>
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005163
    obo:IAO_0000115 "A SARS-CoV-2 recombinant viral vector vaccine composed of Ad26 and Ad5 vectors expressing S protein that lyophilised." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang, Rohit Goru, Oliver He" ;
    obo:IAO_0000119 "PubMed:32896291", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php", "https://en.wikipedia.org/wiki/Gam-COVID-Vac" ;
    obo:VO_0003158 "Gam-COVID-Vac" ;
    a owl:Class ;
    rdfs:label "Sputnik V" ;
    rdfs:subClassOf obo:VO_0005268, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000636
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:VO_0001081
                obo:VO_0005178
            )
        ]
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005164
    obo:IAO_0000115 "A SARS-CoV-2 investigational vaccine comprising a self-replicating (replicon) mRNA that encodes for the prefusion spike protein of 2019-nCoV formulated in a lipid nanoparticle" ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "PubMed:32973505" ;
    a owl:Class ;
    rdfs:label "ARCT-021" ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005165
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine developed by AnGes." ;
    obo:IAO_0000117 "Anthony Huffman" ;
    obo:IAO_0000119 "NCT04463472" ;
    a owl:Class ;
    rdfs:label "AG0301-COVID19" ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005166
    obo:IAO_0000115 "A SARS-CoV-2 inactivated whole virus vaccine that produced in Vero cells that is developed by the Beijing Institute of Biological Products." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "ChiCTR2000032459, ChiCTR2000034780", "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php", "https://en.wikipedia.org/wiki/BBIBP-CorV", "https://go.drugbank.com/drugs/DB15807" ;
    a owl:Class ;
    rdfs:label "BBIBP-CorV" ;
    rdfs:subClassOf obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005167
    obo:IAO_0000115 "A SARS-CoV-2 inactivated whole virus vaccine that is developed by the Chinese Academy of Medical Sciences ." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000118 "IMBCAMS COVID-19 vaccine" ;
    obo:IAO_0000119 "PubMed:32376603" ;
    obo:VO_0003099 "Covidful" ;
    a owl:Class ;
    rdfs:label "Chinese Academy of Medical Sciences COVID-19 vaccine" ;
    rdfs:subClassOf obo:VO_0005201, obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005168
    obo:IAO_0000115 "A SARS-CoV-2 mRNA vaccine developed by CureVac AG and CEPI." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "NCT04449276" ;
    a owl:Class ;
    rdfs:label "CVnCoV" ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005169
    obo:IAO_0000115 "A SARS-CoV 2 recombinant viral vector using Gorilla Adenovirus that encodes for SARS-CoV-2 Spike protein." ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "https://www.covidx.eu/grad-cov2" ;
    a owl:Class ;
    rdfs:label "GRAd-COV2" ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:VO_0005177
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005170
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine expressing the SARS-CoV-2 S protein" ;
    obo:IAO_0000117 "Anthony Huffman, Philip Huang" ;
    obo:IAO_0000119 "NCT04445389" ;
    a owl:Class ;
    rdfs:label "GX-19" ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005171
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine that is made of a protein subunit made of the RBD domain of the S protein." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "PMID:32973505" ;
    dc:creator "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "KBP-COVID-19"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005172
    obo:IAO_0000115 "A DNA vaccine that expresses S protein from the pGX9501 vector" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "PMID:32433465" ;
    dc:creator "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "INO-4800"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005173
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine developed by Adimmune Corporation.", "AdimrSC-2f is a candidate vaccine against COVID-19 developed by Adimmune Corporation (Adimmune). Using the baculovirus-insect cells expression system, the recombinant receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein is amplified and purified. AdimrSC-2f is formulated in the different dosages of Spike (S) protein without/with aluminum content as adjuvant." ;
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "NCT04522089", "https://go.drugbank.com/drugs/DB16436", "https://www.smartpatients.com/trials/NCT04522089" ;
    a owl:Class ;
    rdfs:label "AdimrSC-2f"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005174
    obo:IAO_0000115 "A SARS-CoV-2 oral DNA vaccine that delivers plasmids containing synthetic DNA encoding spike protein from SARS-CoV-2." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04334980", "https://www.symvivo.com/covid-19" ;
    a owl:Class ;
    rdfs:label "bacTRL-Spike"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004969 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0005175
    obo:IAO_0000115 "A SARS-CoV-2 mRNA vaccine manufactured by Chulalongkorn University" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04566276" ;
    a owl:Class ;
    rdfs:label "ChulaCov19"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004970 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0005176
    obo:IAO_0000115 "A synthetic modified vaccinia Ankara (MVA)-based SARS-CoV-2 vaccine" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04639466" ;
    a owl:Class ;
    rdfs:label "COH04S1"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005177
    dc:creator "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "gorilla adenovirus vector"@en ;
    rdfs:seeAlso "an adenovirus vaccine vector that uses a gorilla adenovirus." ;
    rdfs:subClassOf obo:VO_0000136 .

obo:VO_0005178
    obo:IAO_0000117 "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "adenovirus serotype 26 vaccine vector"@en ;
    rdfs:seeAlso "NCBI Taxonomy ID: 46928" ;
    rdfs:subClassOf obo:VO_0000136 ;
    foaf:depicted_by "an adenovirus vaccine vector that uses an Adenovirus serotype 26 strain." .

obo:VO_0005179
    obo:IAO_0000115 "A nanoparticle vector composed of lipids." ;
    obo:IAO_0000119 "PMID: 20402623" ;
    dc:creator "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "lipid nanoparticle vector"@en ;
    rdfs:subClassOf obo:VO_0005180 .

obo:VO_0005180
    obo:IAO_0000115 "A vaccine component composed of a synthetic component that is solid and spherical structures ranging to around 100 nm in size and prepared from natural or synthetic polymers." ;
    obo:IAO_0000119 "PMID: 22353619" ;
    dc:creator "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "nanoparticle vector"@en ;
    rdfs:subClassOf obo:VO_0000179 .

obo:VO_0005181
    obo:IAO_0000115 "A chimpanzee adenovirus vaccine vector that  patented by Oxford and derived from ChAd serotype Y25 that exchanges the native E4 orf4, orf6 and orf6/7 genes for those from HAdV-C5" ;
    obo:IAO_0000119 "PMID: 29527232" ;
    a owl:Class ;
    rdfs:label "chimpanzee adenovirus Oxford1 vaccine vector"@en ;
    rdfs:seeAlso "ChAdOx1" ;
    rdfs:subClassOf obo:VO_0001055 .

obo:VO_0005182
    obo:IAO_0000115 "A chimpanzee adenovirus vaccine vector developed by Oxford by deleting E1/E3  from ChAd68 with a modified E4 region." ;
    obo:IAO_0000119 "PMID: 29527232" ;
    a owl:Class ;
    rdfs:label "chimpanzee adenovirus Oxford2 vaccine vector"@en ;
    rdfs:seeAlso "ChAdOx2" ;
    rdfs:subClassOf obo:VO_0001055 .

obo:VO_0005183
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine developed by Providence Health & Services." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04627675" ;
    a owl:Class ;
    rdfs:label "CORVax12"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005184
    obo:IAO_0000115 "A SARS-CoV-2 recombinant vector vaccine employing the lentiviral vector system and developed by Shenzhen Geno-Immune Medical Institute." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04299724" ;
    a owl:Class ;
    rdfs:label "COVID-19 aAPC vaccine"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005185
    obo:IAO_0000115 "A SARS-CoV-2 refrigerator-stable mRNA vaccine by Moderna that encodes for the portions of the SARS-CoV-2 spike protein critical for neutralization, specifically the Receptor Binding Domain (RBD) and N-terminal Domain (NTD)" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04813796", "https://investors.modernatx.com/news-releases/news-release-details/first-participants-dosed-phase-1-study-evaluating-mrna-1283" ;
    a owl:Class ;
    rdfs:label "mRNA-1283"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005186
    obo:IAO_0000115 "A prophylactic plasmid DNA Vaccine for SARS CoV-2 by Entos Pharmaceuticals" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04591184" ;
    a owl:Class ;
    rdfs:label "Covigenix VAX-001"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005187
    obo:IAO_0000115 "A SARS-CoV-2 live, attenuated vaccine manufactured by Codagenix, Inc." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04619628" ;
    a owl:Class ;
    rdfs:label "COVI-VAC"@en ;
    rdfs:subClassOf obo:VO_0005204, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005188
    obo:IAO_0000115 "A SARS-CoV-2 inactivated vaccine developed by Health Institutes of Turkey" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "ERUCOV-VAC"@en ;
    obo:IAO_0000119 "NCT04691947" ;
    a owl:Class ;
    rdfs:label "TURKOVAC" ;
    rdfs:subClassOf obo:VO_0005201, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005189
    obo:IAO_0000115 "A SARS-CoV-2 human adenovirus serotype 5 (hAd5) vector vaccine with E1/E2b/E3 deletions expressing SARS-CoV-2 viral antigen spike fusion protein and nucleocapsid with an enhanced T-cell stimulation domain." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04591717" ;
    a owl:Class ;
    rdfs:label "hAd5-COVID-19"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005190
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine developed by University Hospital Tuebingen" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04546841" ;
    a owl:Class ;
    rdfs:label "IMP CoVac-1"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005191
    obo:IAO_0000115 "A SARS-CoV-2 recombinant vector vaccine that contains a Modified Vaccinia Virus Ankara (MVA) vector expressing the SARS-CoV-2 spike protein (S)" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04569383" ;
    a owl:Class ;
    rdfs:label "MVA-SARS-2-S"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005192
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine that contains the Spike (S) protein with CpG 1018 and aluminum content as adjuvant." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04487210" ;
    a owl:Class ;
    rdfs:label "MVC-COV1901"@en ;
    rdfs:subClassOf obo:VO_0005269, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0003154
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003153 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0004978 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0005193
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine developed by Vaxine Pty Ltd and CinnaGen Co. and adjuvanted with Advax" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000118 "SpikoGen" ;
    obo:IAO_0000119 "NCT04453852" ;
    a owl:Class ;
    rdfs:label "COVAX-19"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0005207
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005194
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine with the S1 component of the SARS-CoV-2 spike (S) protein and SWE adjuvant." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04702178" ;
    a owl:Class ;
    rdfs:label "COVAC"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005195
    obo:IAO_0000115 "A SARS-CoV-2 vaccine that uses a recombinant vesicular stomatitis virus (rVSV) platform, and is made by Merck. Development of the vaccine was discontinued on January 25, 2021." ;
    obo:IAO_0000117 "Philip Huang, Oliver He" ;
    obo:IAO_0000119 "https://www.merck.com/news/merck-discontinues-development-of-sars-cov-2-covid-19-vaccine-candidates-continues-development-of-two-investigational-therapeutic-candidates/" ;
    a owl:Class ;
    rdfs:label "V590"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005196
    obo:IAO_0000115 "A SARS-CoV-2 adenoviral vector-based oral vaccine by Vaxart expressing a SARS-CoV-2 antigen and dsRNA adjuvant" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04563702" ;
    a owl:Class ;
    rdfs:label "VXA-CoV2-1"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005197
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine manufactured by SK Bioscience Co., Ltd., and equipped with an aluminum hydroxide adjuvant" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04750343" ;
    a owl:Class ;
    rdfs:label "GBP510"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005198
    obo:IAO_0000117 "Philip Huang, Rohit Goru, Oliver He" ;
    a owl:Class ;
    rdfs:label "COVID-19 RNA vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000728
    ] .

obo:VO_0005199
    obo:IAO_0000117 "Philip Huang, Rohit Goru, Oliver He" ;
    a owl:Class ;
    rdfs:label "COVID-19 recombinant vector vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000484
            obo:VO_0004908
        )
    ] .

obo:VO_0005200
    obo:IAO_0000117 "Philip Huang, Rohit Goru, Oliver He" ;
    a owl:Class ;
    rdfs:label "COVID-19 recombinant adenoviral vector vaccine"@en ;
    rdfs:subClassOf obo:VO_0005199 .

obo:VO_0005201
    obo:IAO_0000117 "Philip Huang, Rohit Goru, Oliver He" ;
    a owl:Class ;
    rdfs:label "COVID-19 inactivated vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908 .

obo:VO_0005202
    obo:IAO_0000117 "Philip Huang" ;
    a owl:Class ;
    rdfs:label "COVID-19 subunit vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000624
    ] .

obo:VO_0005203
    obo:IAO_0000117 "Philip Huang" ;
    a owl:Class ;
    rdfs:label "COVID-19 DNA vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908 .

obo:VO_0005204
    obo:IAO_0000117 "Philip Huang" ;
    a owl:Class ;
    rdfs:label "COVID-19 live, attenuated vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908 .

obo:VO_0005205
    obo:IAO_0000117 "Philip Huang" ;
    a owl:Class ;
    rdfs:label "COVID-19 virus-like particle vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908 .

obo:VO_0005206
    obo:IAO_0000115 "A vaccine adjuvant comprised of 40 nm nanoparticles composed of Quillaja saponins, cholesterol and phospholipid." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "PMID: 22844480" ;
    a owl:Class ;
    rdfs:label "Matrix-M vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001267 .

obo:VO_0005207
    obo:IAO_0000115 "A polysaccharide adjuvant derived from delta inulin" ;
    obo:IAO_0000116 """Chemical Nature: Carbohydrate
Mechanism of Action: Complement, Dendritic cells (unknown receptor), Other, Unknown
Immune profile induced: mixed Th1/Th2
By routes: IM, IN, IP, SQ, inhalation,
Point of Contact: Nikolai Petrovsky, Vaxine
https://www.ncbi.nlm.nih.gov/pubmed/?term=31009889
https://www.ncbi.nlm.nih.gov/pubmed/?term=25520500
https://www.ncbi.nlm.nih.gov/pubmed/?term=28758637
https://www.ncbi.nlm.nih.gov/pubmed/?term=23864620
https://www.ncbi.nlm.nih.gov/pubmed/?term=24342245
https://www.ncbi.nlm.nih.gov/pubmed/?term=23306367
https://www.ncbi.nlm.nih.gov/pubmed/?term=21147758
https://www.ncbi.nlm.nih.gov/pubmed/?term=15479440
https://www.ncbi.nlm.nih.gov/pubmed/?term=26031451
https://www.ncbi.nlm.nih.gov/pubmed/?term=25659269
https://www.ncbi.nlm.nih.gov/pubmed/?term=33883559
https://www.ncbi.nlm.nih.gov/pubmed/?term=30312742
https://www.ncbi.nlm.nih.gov/pubmed/?term=21736913
https://www.ncbi.nlm.nih.gov/pubmed/?term=30218687
https://www.ncbi.nlm.nih.gov/pubmed/?term=25459531
https://www.ncbi.nlm.nih.gov/pubmed/?term=24958701
https://www.ncbi.nlm.nih.gov/pubmed/?term=25516480
https://www.ncbi.nlm.nih.gov/pubmed/?term=20130134
https://www.ncbi.nlm.nih.gov/pubmed/?term=23388724
https://www.ncbi.nlm.nih.gov/pubmed/?term=21169215
https://www.ncbi.nlm.nih.gov/pubmed/?term=30832356
https://www.ncbi.nlm.nih.gov/pubmed/?term=30322015
https://www.ncbi.nlm.nih.gov/pubmed/?term=28602608
https://www.ncbi.nlm.nih.gov/pubmed/?term=28676380
https://www.ncbi.nlm.nih.gov/pubmed/?term=33542494
https://www.ncbi.nlm.nih.gov/pubmed/?term=26232344
https://www.ncbi.nlm.nih.gov/pubmed/?term=22728225
https://www.ncbi.nlm.nih.gov/pubmed/?term=22728225
https://www.ncbi.nlm.nih.gov/pubmed/?term=25267153
https://www.ncbi.nlm.nih.gov/pubmed/?term=31300280
https://www.ncbi.nlm.nih.gov/pubmed/?term=28301280
https://www.ncbi.nlm.nih.gov/pubmed/?term=22717330
https://www.ncbi.nlm.nih.gov/pubmed/?term=26177480
https://www.ncbi.nlm.nih.gov/pubmed/?term=10000000
https://www.ncbi.nlm.nih.gov/pubmed/?term=27342914
https://www.ncbi.nlm.nih.gov/pubmed/?term=12""" ;
    obo:IAO_0000117 "Nikolai Petrovsky, Wolfgang Leitner, Philip Huang, Oliver He" ;
    obo:IAO_0000119 "PMID: 22728225", "https://vac.niaid.nih.gov/view?id=37", "https://www.ncbi.nlm.nih.gov/pubmed/?term=10000000", "https://www.ncbi.nlm.nih.gov/pubmed/?term=12", "https://www.ncbi.nlm.nih.gov/pubmed/?term=15479440", "https://www.ncbi.nlm.nih.gov/pubmed/?term=20130134", "https://www.ncbi.nlm.nih.gov/pubmed/?term=21147758", "https://www.ncbi.nlm.nih.gov/pubmed/?term=21169215", "https://www.ncbi.nlm.nih.gov/pubmed/?term=21736913", "https://www.ncbi.nlm.nih.gov/pubmed/?term=22717330", "https://www.ncbi.nlm.nih.gov/pubmed/?term=22728225", "https://www.ncbi.nlm.nih.gov/pubmed/?term=23306367", "https://www.ncbi.nlm.nih.gov/pubmed/?term=23388724", "https://www.ncbi.nlm.nih.gov/pubmed/?term=23864620", "https://www.ncbi.nlm.nih.gov/pubmed/?term=24342245", "https://www.ncbi.nlm.nih.gov/pubmed/?term=24958701", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25267153", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25459531", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25516480", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25520500", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25659269", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26031451", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26177480", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26232344", "https://www.ncbi.nlm.nih.gov/pubmed/?term=27342914", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28301280", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28602608", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28676380", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28758637", "https://www.ncbi.nlm.nih.gov/pubmed/?term=30218687", "https://www.ncbi.nlm.nih.gov/pubmed/?term=30312742", "https://www.ncbi.nlm.nih.gov/pubmed/?term=30322015", "https://www.ncbi.nlm.nih.gov/pubmed/?term=30832356", "https://www.ncbi.nlm.nih.gov/pubmed/?term=31009889", "https://www.ncbi.nlm.nih.gov/pubmed/?term=31300280", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33542494", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33883559" ;
    obo:VO_0005328 37 ;
    a owl:Class ;
    rdfs:label "Advax vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001359, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005208
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://www.curevac.com/en/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "CureVac AG"@en .

obo:VO_0005209
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Research Institute for Biological Safety Problems"@en .

obo:VO_0005210
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Bharat Biotech International Limited"@en .

obo:VO_0005211
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "University of Munich (Ludwig-Maximilians)"@en .

obo:VO_0005212
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "West China Hospital"@en .

obo:VO_0005213
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "University Hospital Tuebingen"@en .

obo:VO_0005214
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Shenzhen Geno-Immune Medical Institute"@en .

obo:VO_0005215
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Providence Health & Services"@en .

obo:VO_0005216
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "City of Hope Medical Center"@en .

obo:VO_0005217
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://codagenix.com/" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Codagenix, Inc."@en .

obo:VO_0005218
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Center for Genetic Engineering and Biotechnology"@en .

obo:VO_0005219
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Biological E. Ltd"@en .

obo:VO_0005220
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "GeneOne Life Science, Inc."@en .

obo:VO_0005221
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Nanogen Pharmaceutical Biotechnology"@en .

obo:VO_0005222
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Shionogi"@en .

obo:VO_0005223
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Altimmune, Inc."@en .

obo:VO_0005224
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Erciyes University"@en .

obo:VO_0005225
    obo:IAO_0000117 "Philip Huang" ;
    a obo:VO_0000299, owl:NamedIndividual ;
    rdfs:label "Vaccine and Infectious Disease Organization"@en .

obo:VO_0005226
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine manufactured by the Razi Vaccine and Serum Research Institute with a Spike protein antigen" ;
    obo:IAO_0000117 "Philip Huang" ;
    a owl:Class ;
    rdfs:label "Razi Cov Pars"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005227
    obo:IAO_0000115 "A SARS-CoV-2 recombinant adenoviral vector vaccine that is manufactured by Bharat Biotech International Ltd. and administered intranasally" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04751682" ;
    a owl:Class ;
    rdfs:label "BBV154"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005228
    obo:IAO_0000115 "A SARS-CoV-2 Chimpanzee Adenovirus serotype 6 vector vaccine manufactured by Gritstone Oncology and the National Institute of Allergy and Infectious Diseases" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04776317" ;
    a owl:Class ;
    rdfs:label "ChAdV68-S"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005229
    obo:IAO_0000115 "A SARS-CoV-2 inactivated vaccine by Shifa Pharmed" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.irct.ir/trial/52701" ;
    a owl:Class ;
    rdfs:label "COVIran Barakat"@en ;
    rdfs:subClassOf obo:VO_0005201, obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005230
    obo:IAO_0000115 "A SARS-CoV-2 plasmid DNA vaccine manufactured by Takis and Rottapharm Biotech" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-003734-20/IT" ;
    a owl:Class ;
    rdfs:label "COVID-eVax"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005231
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine manufactured by University of Sydney, Bionet Co., and Technovalia" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04742842" ;
    a owl:Class ;
    rdfs:label "COVIGEN"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005232
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine by EuBiologics Co., Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04783311" ;
    a owl:Class ;
    rdfs:label "EuCorVac-19"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005233
    obo:IAO_0000115 "A SARS-CoV-2  lipid nanoparticle (LNP)-encapsulated mRNA-based vaccine that encodes for a full-length, prefusion stabilized S protein of the SARS-CoV-2 B.1.351 variant" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04785144" ;
    a owl:Class ;
    rdfs:label "mRNA-1273.351"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005234
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine by SK Bioscience" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04760743" ;
    a owl:Class ;
    rdfs:label "NBP2001"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005235
    obo:IAO_0000115 "A SARS-CoV-2 recombinant viral vector vaccine by Mahidol University" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04764422" ;
    a owl:Class ;
    rdfs:label "NDV-HXP-S"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005236
    obo:IAO_0000115 "A SARS-CoV-2 mRNA vaccine by Providence Therapeutics" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04765436" ;
    a owl:Class ;
    rdfs:label "PTX-COVID19-B"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005237
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine manufactured by Walter Reed Army Institute of Research" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04784767" ;
    a owl:Class ;
    rdfs:label "SpFN"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005238
    obo:IAO_0000115 "A SARS-CoV-2 virus-like particle vaccine that expresses a modified version of the SARS-CoV-2 spike (S) glycoprotein and is equipped with an aluminum phosphate adjuvant. It is manufactured by VBI Vaccines Inc. and is delivered intramuscularly." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04773665" ;
    a owl:Class ;
    rdfs:label "VBI-2902a"@en ;
    rdfs:subClassOf obo:VO_0005205, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000128
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005239
    obo:IAO_0000115 "A SARS-CoV-2 inactivated vaccine developed by Organization of Defensive Innovation and Research in Iran" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.irct.ir/trial/54133" ;
    a owl:Class ;
    rdfs:label "FAKHRAVAC"@en ;
    rdfs:subClassOf obo:VO_0005201, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005240
    obo:IAO_0000115 "A SARS-CoV-2 live, attenuated vaccine manufactured by Meissa Vaccines, Inc. that expresses the spike (S) protein of SARS-CoV-2." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04798001" ;
    a owl:Class ;
    rdfs:label "MV-014-212"@en ;
    rdfs:subClassOf obo:VO_0005204, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005241
    obo:IAO_0000115 "A SARS-CoV-2 mRNA vaccine that is manufactured by Sanofi Pasteur" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04798027" ;
    a owl:Class ;
    rdfs:label "MRT5500"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005242
    obo:IAO_0000115 "An object property that represents a relation between a material entity and biological process" ;
    obo:IAO_0000117 "Anthony Huffman, Oliver He" ;
    a owl:ObjectProperty ;
    rdfs:domain obo:BFO_0000040 ;
    rdfs:label "up-expressed as immune signature of"@en ;
    rdfs:range obo:BFO_0000015 .

obo:VO_0005243
    obo:IAO_0000115 "A SARS-CoV-2 inactivated whole virus vaccine developed by the Chumakov Centre at the Russian Academy of Sciences" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "CoviVac"@en ;
    rdfs:subClassOf obo:VO_0005266, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005244
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine manufactured by Instituto Finlay de Vacunas" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://rpcec.sld.cu/trials/RPCEC00000366-En" ;
    a owl:Class ;
    rdfs:label "FINLAY-FR-1"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005245
    obo:IAO_0000115 "A SARS-CoV-2 mRNA vaccine manufactured by Daiichi Sankyo Co., Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:VO_0003159 "Daiichi Sankyo Co., Ltd." ;
    a owl:Class ;
    rdfs:label "DS-5670a"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005246
    obo:IAO_0000115 "A SARS-CoV-2 recombinant Newcastle Disease Virus vector vaccine expressing membrane-anchored pre-fusion-stabilized trimeric SARS-CoV-2 S protein" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04830800" ;
    a owl:Class ;
    rdfs:label "COVIVAC"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0001060
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005247
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine developed by Livzon Mabpharm Inc." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "ChiCTR2100045107" ;
    a owl:Class ;
    rdfs:label "V-01"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005248
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine developed by the National Vaccine and Serum Institute of China" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04869592" ;
    a owl:Class ;
    rdfs:label "COVID-19 subunit vaccine by National Vaccine and Serum Institute of China"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005249
    obo:IAO_0000115 "A SARS-COV-2 temperature-sensitive self-replicating RNA vaccine expressing the receptor binding domain of the SARS-CoV-2 spike protein." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04863131" ;
    obo:VO_0003159 "Elixirgen Therapeutics, Inc." ;
    a owl:Class ;
    rdfs:label "EXG-5003"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005250
    obo:IAO_0000115 "A SARS-CoV-2 inactivated vaccine developed by KM Biologics Co., Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "jRCT2071200106" ;
    a owl:Class ;
    rdfs:label "KD-414"@en ;
    rdfs:subClassOf obo:VO_0005201, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005251
    obo:IAO_0000115 "A COVID-19 virus-like particle vaccine developed by the Scientific and Technological Research Council of Turkey" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04818281" ;
    a owl:Class ;
    rdfs:label "COVID-19 VLP vaccine by the Scientific and Technological Research Council of Turkey"@en ;
    rdfs:subClassOf obo:VO_0005205, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005252
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by Jiangsu Rec-Biotechnology Co., Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04818801" ;
    a owl:Class ;
    rdfs:label "ReCOV"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005253
    obo:IAO_0000115 "A SARS-CoV-2 inactivated virus vaccine by Kocak Farma" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04838080" ;
    a owl:Class ;
    rdfs:label "Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0005201, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005254
    obo:IAO_0000115 "A SARS-CoV-2 recombinant adenoviral vector vaccine by Tetherex Pharmaceutical Corporation" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04839042" ;
    a owl:Class ;
    rdfs:label "SC-Ad6-1"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005255
    obo:IAO_0000115 "A COVID-19 virus-like particle vaccine developed by Radboud University" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04839146" ;
    a owl:Class ;
    rdfs:label "ABNCoV2"@en ;
    rdfs:subClassOf obo:VO_0005205, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0001301
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005256
    obo:IAO_0000115 "A SARS-CoV-2 Lipid-Inorganic Nanoparticle (LION™) formulated replicating mRNA vaccine that encodes for a full-length spike (S) protein of the SARS-CoV-2 virus" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04844268" ;
    a owl:Class ;
    rdfs:label "HDT-301"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005257
    obo:IAO_0000115 "A SARS-CoV-2 inactivated virus vaccine by the Scientific and Technological Research Council of Turkey adjuvanted by aluminum hydroxide and CpG ODN" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04866069" ;
    a owl:Class ;
    rdfs:label "COVID-19 inactivated vaccine by the Scientific and Technological Research Council of Turkey"@en ;
    rdfs:subClassOf obo:VO_0005201, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005258
    obo:IAO_0000115 "An MF59-adjuvanted SARS-CoV-2 subunit vaccine based on recombinant SARS-CoV-2 spike glycoprotein stabilised in a pre-fusion conformation by a novel molecular clamp (spike glycoprotein-clamp [sclamp])" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "PubMed ID: 33887208" ;
    a owl:Class ;
    rdfs:label "MF59-adjuvanted SARS-CoV-2 Sclamp vaccine"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000529 ;
        owl:someValuesFrom obo:VO_0001301
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005259
    obo:IAO_0000115 "A recombinant Newcastle Disease Virus vectored vaccine for SARS-CoV-2 by Laboratorio Avi-Mex" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04871737" ;
    a owl:Class ;
    rdfs:label "COVID-19 rNDV vector vaccine by Laboratorio Avi-Mex"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005260
    obo:IAO_0000115 "A SARS-CoV-2 mRNA vaccine by Shanghai East Hospital and Stemirna Therapeutics" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "ChiCTR2100045984" ;
    a owl:Class ;
    rdfs:label "COVID-19 mRNA vaccine by Shanghai East Hospital and Stemirna Therapeutics"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005261
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by OSE Immunotherapeutics" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04885361" ;
    a owl:Class ;
    rdfs:label "CoVepiT"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000532
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005262
    obo:IAO_0000115 "A SARS-CoV-2 recombinant viral vector vaccine by the German Center for Infection Research" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04895449" ;
    a owl:Class ;
    rdfs:label "MVA-SARS-2-ST"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0001107
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005263
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine that is orally administered and manufactured by Syneos Health" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04893512" ;
    obo:VO_0003159 "Syneos Health" ;
    a owl:Class ;
    rdfs:label "CoV2-OGEN1"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000886
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005264
    obo:IAO_0000115 "A COVID-19 vaccine that is authorized for emergent use, which is typically authorized based on an Emergency Use Authorization (EUA)." ;
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php", "https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-vaccines" ;
    a owl:Class ;
    rdfs:label "authorized COVID-19 vaccine"@en ;
    rdfs:subClassOf obo:VO_0004908 .

obo:VO_0005265
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "authorized COVID-19 RNA vaccine"@en ;
    rdfs:subClassOf obo:VO_0005198, obo:VO_0005264 .

obo:VO_0005266
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "authorized inactivated COVID-19 vaccine"@en ;
    rdfs:subClassOf obo:VO_0005201, obo:VO_0005264 .

obo:VO_0005267
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "authorized COVID-19 recombinant vector vaccine"@en ;
    rdfs:subClassOf obo:VO_0005199, obo:VO_0005264 .

obo:VO_0005268
    obo:IAO_0000117 "Oliver He" ;
    a owl:Class ;
    rdfs:label "authorized COVID-19 recombinant adenoviral vector vaccine"@en ;
    rdfs:subClassOf obo:VO_0005200, obo:VO_0005267 .

obo:VO_0005269
    obo:IAO_0000117 "Oliver He, Philip Huang" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "authorized COVID-19 subunit vaccine"@en ;
    rdfs:subClassOf obo:VO_0005202, obo:VO_0005264 .

obo:VO_0005270
    obo:IAO_0000115 "IV270 is a low–molecular weight TLR7 agonist conjugated to a phospholipid and is a highly potent and stable immune activator" ;
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: TLR7
Mechanism of Action: Activation of innate immune pathways
Immune profile induced: Th1-biased
Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces CD8 T cells, (3) Induces epitope spreading, (4) Provides innate protection, (5) Promotes antibody affinity maturation, (6) Promotes antibody epitope spreading By routes: intramuscular and intranasal.
Point of Contact: Dennis Carson, UCSD""" ;
    obo:IAO_0000117 "Dennis Carson, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "1V270" ;
    obo:IAO_0000119 "https://pubmed.ncbi.nlm.nih.gov/25568203/", "https://pubmed.ncbi.nlm.nih.gov/28724768/", "https://pubmed.ncbi.nlm.nih.gov/32636840/", "https://vac.niaid.nih.gov/view?id=6" ;
    obo:VO_0005328 6 ;
    a owl:Class ;
    rdfs:label "1V270 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005272
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005271
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: TLR4
Mechanism of Action: Innate immune activation
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: (1) Induces mucosal immunity, (2) Anti-inflammatory, (3) Promotes antibody epitope spreading. By routes: intramuscular and intranasal.
Point of Contact: Dennis Carson, UCSD""" ;
    obo:IAO_0000117 "Dennis Carson, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "2B182C" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=7", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25568203", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28724768", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32636840" ;
    obo:VO_0005328 7 ;
    a owl:Class ;
    rdfs:label "2B182C vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005272
    obo:IAO_0000115 "A role of a material entity that binds to TLR7 and activates the receptor for pathogen recognition and activation of innate immunity." ;
    obo:IAO_0000116 "TLR7 agonist role" ;
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000118 "Toll-like receptor 7 agonist role" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/TLR7" ;
    a owl:Class ;
    rdfs:label "TLR7 receptor role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005273
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine manufactured by the Research Institute for Biological Safety Problems in Kazakhstan" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04930003" ;
    a owl:Class ;
    rdfs:label "QazCoVac-P"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005274
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_cell" ;
    a owl:Class ;
    rdfs:label "Th1 immunity stimulatory role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005275
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_cell" ;
    a owl:Class ;
    rdfs:label "Th2 immunity stimulatory role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005276
    obo:IAO_0000115 "A SARS-CoV-2 self-amplifying RNA vaccine sponsored by MRC/UVRI and LSHTM Uganda Research Unit" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04934111" ;
    a owl:Class ;
    rdfs:label "LNP-nCOV saRNA-02"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005277
    obo:IAO_0000115 "A multivalent SARS-CoV-2 mRNA booster vaccine which combines mRNA-1273, Moderna’s authorized vaccine against ancestral strains, and mRNA-1273.351 in a single vaccine at the 50 µg dose level and lower." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-it-has-shipped-variant-specific-vaccine" ;
    a owl:Class ;
    rdfs:label "mRNA-1273.211"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005278
    obo:IAO_0000115 "A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor. In (H115D)VHL35 peptide, histidine is substituted for an aspartic acid in position 115. It might be used to elicit or boost cellular immunity to cancers that expressing the von Hippel-Lindau mutation." ;
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28776" ;
    a owl:Class ;
    rdfs:label "(H115D)VHL35 Peptide cancer vaccine"@en ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0005279
    a owl:NamedIndividual ;
    rdfs:label "VAC"@en .

obo:VO_0005280
    obo:IAO_0000115 "An NIAID compendium repository that stores vaccine adjuvants derived from their research studies." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi, Wolfgang Leitner" ;
    obo:IAO_0000118 "VAC" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/" ;
    a obo:OBI_0000245, owl:NamedIndividual ;
    rdfs:label "Vaccine Adjuvant Compendium"@en .

obo:VO_0005281
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: Dendritic cells (unknown receptor)
Mechanism of Action: Innate immune activation
Immune profile induced: Th1-biased
Other Features/Characteristics: Other. Specify: Co-adjuvant for TLR4 ligands
Point of Contact: Dennis Carson, UCSD""" ;
    obo:IAO_0000117 "Dennis Carson, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "2E151"^^xsd:string ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=9" ;
    obo:VO_0005328 9 ;
    a owl:Class ;
    rdfs:label "2E151 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005282
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: CLR (Dectin, Mincle)
Mechanism of Action: None/Unknown
Immune profile induced: Th17-component
Other Features/Characteristics: None
Point of Contact: Kendal Ryter, U. Montana & Inimmune""" ;
    obo:IAO_0000117 "Kendal Ryter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "UM-1098" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=27" ;
    a owl:Class ;
    rdfs:label "UM-1098 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005313
    ] .

obo:VO_0005283
    obo:IAO_0000116 """Chemical Nature: Small molecule and Synthetic derivative of natural compound
Receptor: Unknown and NLRP3
Mechanism of Action: Presumably the same as QS-21 in the absence of dose-limiting toxicity
Immune profile induced: Th1-biased
Other Features/Characteristics: None
Point of Contact: Melissa Malhame, Adjuvance Technologies""" ;
    obo:IAO_0000117 "Melissa Malhame, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "TQL-1055" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=36" ;
    a owl:Class ;
    rdfs:label "TQL-1055 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005284
    obo:IAO_0000116 """Chemical Nature: Emulsion
Receptor: TLR2 and TLR4
Mechanism of Action: Activation of mucosal and systemic immunity
Immune profile induced: Th1/Th17
Other Features/Characteristics: Promotes antibody affinity maturation
Point of Contact: Ali Fattom, BlueWillow Biologics""" ;
    obo:IAO_0000117 "Ali Fattom, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "NanoVax/NE01" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=22", "https://www.ncbi.nlm.nih.gov/pubmed/?term=31495593", "https://www.ncbi.nlm.nih.gov/pubmed/?term=31515143" ;
    a owl:Class ;
    rdfs:label "NanoVax/NE01 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005307
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005314
    ] .

obo:VO_0005285
    obo:IAO_0000116 """Chemical Nature: Other
Receptor: TLR4
Mechanism of Action: TLR4 agonist
Immune profile induced: Th1-biased
Other Features/Characteristics: None/Unknown
Point of Contact: Darrick Carter, PAI Life Sciences""" ;
    obo:IAO_0000117 "Darrick Carter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "MiT4" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=16" ;
    a owl:Class ;
    rdfs:label "MiT4 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005286
    obo:IAO_0000116 """Chemical Nature: (1) Natural compound, (2) Carbohydrate, (3) Combination adjuvant
Receptor: CLR (Dectin, Mincle) and NAIP
Mechanism of Action: Activation of Dectin-2-expressing innate immune cells; dual targeting of injection site and draining lymph node.
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: Promotes antibody epitope spreading
Point of Contact: Ivan Zanoni, Boston Children's Hospital""" ;
    obo:IAO_0000117 "Ivan Zanoni, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=14" ;
    a owl:Class ;
    rdfs:label "Mannadjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005287
    obo:IAO_0000116 """Chemical Nature: Combination Adjuvant
Receptor: TLR4
Mechanism of Action: TLR4 agonist plus potential inflammasome
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None/Unknown
Point of Contact: Darrick Carter, PAI Life Sciences""" ;
    obo:IAO_0000117 "Darrick Carter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "LiT4" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=20" ;
    a owl:Class ;
    rdfs:label "LiT4 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005288
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: TLR7 and TLR8
Mechanism of Action: None/Unknown
Immune profile induced: Th1-biased
Other Features/Characteristics: None
Point of Contact: Kendal Ryter, U. Montana & Inimmune""" ;
    obo:IAO_0000117 "Kendal Ryter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "INI-4001" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=28" ;
    a owl:Class ;
    rdfs:label "INI-4001 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005272
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005306
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005289
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: TLR4
Mechanism of Action: None/Unknown
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Kendal Ryter, U. Montana & Inimmune""" ;
    obo:IAO_0000117 "Kendal Ryter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "INI-2004" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=26" ;
    a owl:Class ;
    rdfs:label "INI-2004 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005290
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: TLR4
Mechanism of Action: None/Unknown
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Kendal Ryter, U. Montana & Inimmune""" ;
    obo:IAO_0000117 "Kendal Ryter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "INI-2002" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=29" ;
    a owl:Class ;
    rdfs:label "INI-2002 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005291
    obo:IAO_0000116 """Chemical Nature: Small molecule and Combination adjuvant
Receptor: TLR4 and TLR7
Mechanism of Action: Activation of antigen presenting cells and stimulating B cell proliferation
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces CD8 T cells, (3) Induces epitope spreading, (4) Provides innate protection, (5) Promotes antibody epitope spreading. By routes: intramuscular and intranasal.
Point of Contact: Dennis Carson, UCSD""" ;
    obo:IAO_0000117 "Dennis Carson, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "Fos47" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=5", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25568203", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28724768", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32636840" ;
    a owl:Class ;
    rdfs:label "Fos47 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005272
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005292
    obo:IAO_0000116 """Chemical Nature: Emulsion
Receptor: TLR4
Mechanism of Action: Squalene emulsion plus TLR4
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Darrick Carter, PAI Life Sciences""" ;
    obo:IAO_0000117 "Darrick Carter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "EmT4" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=17" ;
    a owl:Class ;
    rdfs:label "EmT4 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001355, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005293
    obo:IAO_0000116 """Chemical Nature: Emulsion
Receptor: Unknown
Mechanism of Action: Squalene emulsion possibly triggering inflammasome or through extracellular ATP
Immune profile induced: None
Other Features/Characteristics: None
Point of Contact: Darrick Carter, PAI Life Sciences""" ;
    obo:IAO_0000117 "Darrick Carter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "Em" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=18" ;
    a owl:Class ;
    rdfs:label "Em vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0005294
    obo:IAO_0000116 """Chemical Nature: (1) Synthetic derivative of natural compound, (2) Nucleic acid
Receptor: TLR3
Mechanism of Action: TLR3, possibly RIG-I - agonist
Immune profile induced: Th1-biased
Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces CD8 T cells, (3) Provides innate protection. By routes: SQ, IM.
Point of Contact: Carolina Lopez, University of Washington at St Louis""" ;
    obo:IAO_0000117 "Carolina Lopez, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "DDO", "DDO (Defective viral genome-Derived Oligonucleotide)", "Defective viral genome-Derived Oligonucleotide" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=30", "https://www.ncbi.nlm.nih.gov/pubmed/?term=24099876", "https://www.ncbi.nlm.nih.gov/pubmed/?term=29861183" ;
    a owl:Class ;
    rdfs:label "DDO (Defective viral genome-Derived Oligonucleotide) vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005305
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005295
    obo:IAO_0000116 """Chemical Nature: Synthetic derivative of natural compound
Receptor: Unknown
Mechanism of Action: (1) Antigen carrier, (2) Innate immune enhancer/activator
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces CD8 T cells, (3) Provides innate protection, (4) Other, (5) Promotes antibody affinity maturation, (6) High stability. By routes: IM, IN, IP, IN, ID, IVag. Specify: Safe for systemic or mucosal administration
Point of Contact: Tulin Morcol, Captivate Pharma""" ;
    obo:IAO_0000117 "Tulin Morcol, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "CaPNP (CaPtivant)(TM)" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=11", "https://www.ncbi.nlm.nih.gov/pubmed/?term=11063495", "https://www.ncbi.nlm.nih.gov/pubmed/?term=12204953", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28716554", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28933657", "https://www.ncbi.nlm.nih.gov/pubmed/?term=31591662" ;
    obo:VO_0005328 11 ;
    a owl:Class ;
    rdfs:label "CaPNP (CaPtivant)(TM) vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005296
    obo:IAO_0000116 """Chemical Nature: Small molecule, other
Receptor: TLR4
Mechanism of Action: None
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: Other
Point of Contact: Robert Ernst, University of Maryland - Baltimore""" ;
    obo:IAO_0000117 "Robert Ernst, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "BECC470b" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=32", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28487429", "https://www.ncbi.nlm.nih.gov/pubmed/?term=29861179", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33309485" ;
    obo:VO_0005328 32 ;
    a owl:Class ;
    rdfs:label "BECC470b vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005297
    obo:IAO_0000116 """Chemical Nature: (1) Synthetic derivative of natural compound, (2) other
Receptor: TLR4
Mechanism of Action: None
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Robert Ernst, University of Maryland-Baltimore""" ;
    obo:IAO_0000117 "Robert Ernst, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "BECC438s" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=33" ;
    obo:VO_0005328 33 ;
    a owl:Class ;
    rdfs:label "BECC438s vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005298
    obo:IAO_0000116 """Chemical Nature: Small molecule, other
Receptor: TLR4
Mechanism of Action: None
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Robert Ernst, University of Maryland Baltimore""" ;
    obo:IAO_0000117 "Robert Ernst, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "BECC438b" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=31", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28487429", "https://www.ncbi.nlm.nih.gov/pubmed/?term=29861179", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33309485" ;
    obo:VO_0005328 31 ;
    a owl:Class ;
    rdfs:label "BECC438b vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005299
    obo:IAO_0000116 """Chemical Nature: Combination adjuvant
Receptor: TLR4
Mechanism of Action: TLR4 and potentially inflammasome
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Darrick Carter, PAI Life Services""" ;
    obo:IAO_0000117 "Darrick Carter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "AlT4" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=19" ;
    obo:VO_0005328 19 ;
    a owl:Class ;
    rdfs:label "AlT4 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005300
    obo:IAO_0000116 """Chemical Nature: Combination adjuvant
Receptor: TLR3
Mechanism of Action: TLR3 agonist plus potential inflammasome
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Darrick Carter, PAI Life Services""" ;
    obo:IAO_0000117 "Darrick Carter, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "AlT3" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=21" ;
    obo:VO_0005328 21 ;
    a owl:Class ;
    rdfs:label "AlT3 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005305
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005301
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: (1) TLR7, (2) TLR8
Mechanism of Action: TLR7/8 dual agonist - lymph node delivery
Immune profile induced: Th1-biased
Other Features/Characteristics: Promotes antibody affinity maturation
Point of Contact: Sunil David, Virovax""" ;
    obo:IAO_0000117 "Sunil David, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "Alhydroxiquim-II" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=12", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33521604", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33654090" ;
    obo:VO_0005328 12 ;
    a owl:Class ;
    rdfs:label "Alhydroxiquim-II vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005272
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005306
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005302
    obo:IAO_0000116 """Chemical Nature: (1) Synthetic derivative of natural compound, (2) Emulsion, (3) Combination adjuvant, (4) Other
Receptor: TLR4
Mechanism of Action: Adjuplex enhances cross presentation to CD8 T cells and GLA stimulates TLR4 signaling
Immune profile induced: Mixed Th1/Th17
Other Features/Characteristics: None
Point of Contact: Marulasiddappa Suresh, UW Madison""" ;
    obo:IAO_0000117 "Marulasiddappa Suresh, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "Adjuplex+GLA" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=15", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32984856", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33444400", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33767689" ;
    obo:VO_0005328 15 ;
    a owl:Class ;
    rdfs:label "Adjuplex+GLA vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005314
    ] .

obo:VO_0005303
    obo:IAO_0000116 """Chemical Nature: Small molecule
Receptor: Dendritic cells (unknown receptor)
Mechanism of Action: Innate immune activation/enhancer
Immune profile induced: Mixed Th1/Th2
Other Features/Characteristics: None
Point of Contact: Dennis Carson, UCSD""" ;
    obo:IAO_0000117 "Dennis Carson, Wolfgang Leitner, Amogh Madireddi, Oliver He" ;
    obo:IAO_0000118 "2F52" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=8", "https://www.ncbi.nlm.nih.gov/pubmed/?term=29751735" ;
    obo:VO_0005328 8 ;
    a owl:Class ;
    rdfs:label "2F52 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005304
    obo:IAO_0000115 "A role of a material entity that binds to TLR4 and activates the receptor for pathogen recognition and activation of innate immunity." ;
    obo:IAO_0000116 "TLR4 agonist role" ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000118 "Toll-like receptor 4 agonist role" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/TLR4" ;
    a owl:Class ;
    rdfs:label "TLR4 receptor role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005305
    obo:IAO_0000115 "A role of a material entity that binds to TLR3 and activates the receptor for pathogen recognition and activation of innate immunity." ;
    obo:IAO_0000116 "TLR3 agonist role" ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000118 "Toll-like receptor 3 agonist role" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/TLR3" ;
    a owl:Class ;
    rdfs:label "TLR3 receptor role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005306
    obo:IAO_0000115 "A role of a material entity that binds to TLR8 and activates the receptor for pathogen recognition and activation of innate immunity." ;
    obo:IAO_0000116 "TLR8 agonist role" ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000118 "Toll-like receptor 8 agonist role" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/TLR8" ;
    a owl:Class ;
    rdfs:label "TLR8 receptor role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005307
    obo:IAO_0000115 "A role of a material entity that binds to TLR2 and activates the receptor for pathogen recognition and activation of innate immunity." ;
    obo:IAO_0000116 "TLR2 agonist role" ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000118 "Toll-like receptor 2 agonist role" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/TLR2" ;
    a owl:Class ;
    rdfs:label "TLR2 receptor role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005308
    a owl:Class ;
    rdfs:label "immune response profile"@en ;
    rdfs:subClassOf obo:BFO_0000144 .

obo:VO_0005309
    obo:IAO_0000115 "A biased immune profile that is characterized by the presense of T help cells Type 1 T helper (Th1) cells that produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent protective responses." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_cell", "https://pubmed.ncbi.nlm.nih.gov/10579123/" ;
    a owl:Class ;
    rdfs:label "Th1-biased immune profile"@en ;
    rdfs:subClassOf obo:VO_0005308 .

obo:VO_0005310
    obo:IAO_0000115 "A baised immune profile that is characterized by the presense of T type 2 Th (Th2) cells that produce IL-4, IL-5, IL-10, and IL-13, which are responsible for strong antibody production, eosinophil activation, and inhibition of several macrophage functions, thus providing phagocyte-independent protective responses." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_cell", "https://pubmed.ncbi.nlm.nih.gov/10579123/" ;
    a owl:Class ;
    rdfs:label "Th2-biased immune profile"@en ;
    rdfs:subClassOf obo:VO_0005308 .

obo:VO_0005311
    obo:IAO_0000115 "An immune profile that is characterized by the presense of both Type 1 and Type 2 T helper  (Th1 and Th2) cells." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_cell", "https://pubmed.ncbi.nlm.nih.gov/10579123/" ;
    a owl:Class ;
    rdfs:label "Th1/Th2 mixed immune profile"@en ;
    rdfs:subClassOf obo:VO_0005308 .

obo:VO_0005312
    obo:IAO_0000115 "An object property that represents a relation between a material entity (such as vaccine or vaccine adjuvant) and an immune profile where the material entity can induce the immune profile in a host." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    a owl:ObjectProperty ;
    rdfs:label "induces immune profile"@en .

obo:VO_0005313
    obo:IAO_0000115 "An immune profile that is characterized by the presense of T helper 17 cells (Th17) that a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that cause Th17s to differentiate actually inhibit Treg differentiation." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_17_cell" ;
    a owl:Class ;
    rdfs:label "Th17 immune profile"@en ;
    rdfs:subClassOf obo:VO_0005308 .

obo:VO_0005314
    obo:IAO_0000115 "An immune profile that is characterized by the presense of both Type 1 and Type 17 T helper  (Th1 and Th17) cells." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_cell" ;
    a owl:Class ;
    rdfs:label "Th1/Th17 mixed immune profile"@en ;
    rdfs:subClassOf obo:VO_0005308 .

obo:VO_0005315
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by Clover Biopharmaceuticals AUS Pty Ltd that contains the S protein from the B.1.351 variant." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04950751" ;
    a owl:Class ;
    rdfs:label "SCB-2020S"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005316
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by Bagheiat-allah University of Medical Sciences" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "https://en.irct.ir/trial/56987" ;
    a owl:Class ;
    rdfs:label "AmitisGen"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005317
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by Baiya Phytopharm Co., Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04953078" ;
    a owl:Class ;
    rdfs:label "Baiya SARS-CoV-2 Vax 1"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005318
    obo:IAO_0000115 "A SARS-CoV-2 recombinant vector vaccine manufactured by CyanVac LLC" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04954287" ;
    a owl:Class ;
    rdfs:label "CVXGA1"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005319
    obo:IAO_0000115 "A SARS-CoV-2 recombinant vector vaccine by AstraZeneca and Oxford University against variant strain B.1.351" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04973449" ;
    a owl:Class ;
    rdfs:label "AZD2816"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005320
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine manufactured by Shanghai Zerun Biotechnology, Walvax Biotechnology, and CEPI" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04990544" ;
    a owl:Class ;
    rdfs:label "202-CoV"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005321
    obo:IAO_0000115 "A SARS-CoV-2 protein subunit vaccine by Laboratorios HIPRA" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05007509" ;
    a owl:Class ;
    rdfs:label "COVID-19 subunit vaccine by HIPRA"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005322
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine developed by AnGes." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT04993586" ;
    a owl:Class ;
    rdfs:label "AG0302-COVID19"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005323
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "http://www.violinet.org/cov19vaxkb/authorizedcov19vax.php" ;
    a owl:Class ;
    rdfs:label "authorized COVID-19 DNA vaccine"@en ;
    rdfs:subClassOf obo:VO_0005203, obo:VO_0005264 .

obo:VO_0005324
    obo:IAO_0000115 "Advax-CpG55.2 is a combination adjuvant that includes an inulin-based polysaccharide (Advax) and a CpG oligodeoxynucleotide CpG55.2." ;
    obo:IAO_0000116 """Pubmed References:Chemical Nature: (1) combination adjuvant
Mechanism of Action: (1) complement, (2) dendritic cells, (3) other/unknown, (4) TLR9 Immune profile induced: mixed Th1
Other Features/Characteristics: (1) induces CD8 T cells, (2) provides innate protection, (3) anti-inflammatory, (4) promotes antibody affinity maturation, (5) effective in newborns, (6) high stability
By routes: SQ, IM
Point of Contact: Nikolai Petrovsky, Vaxine LTD""" ;
    obo:IAO_0000117 "Nikolai Petrovsky, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000119 "https://pubmed.ncbi.nlm.nih.gov/32636840/", "https://vac.niaid.nih.gov/view?id=38", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32849580", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33301675", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34069575" ;
    obo:VO_0005328 38 ;
    a owl:Class ;
    rdfs:label "Advax-CpG55.2"@en ;
    rdfs:subClassOf obo:VO_0005357, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005325
    obo:IAO_0000115 "VSA-2 is a vaccine adjuvant that is synthesized by derivatizing a natural Momordica saponin in one step.  VSA-2 is chemically stable. VSA-2 is much less toxic than QS-21.  VSA-2 is more Th1-biased than QS-21. Momordica saponins are isolated from widely available and sustainable sources." ;
    obo:IAO_0000116 """Pubmed References:
Chemical Nature: (1) Synthetic derivative of natural compound
Mechanism of Action: unknown
Immune profile induced: mixed Th1/Th2
Other Features/Characteristics: (1) synthetic saponin with lower toxicity and higher stability than QS21
By routes: SQ
Point of Contact: Pengfei Wang, University of Alabama
https://www.ncbi.nlm.nih.gov/pubmed/?term=32101001""" ;
    obo:IAO_0000117 "Pengfei Wang, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "VSA-2" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=42", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32101001" ;
    obo:VO_0005328 42 ;
    a owl:Class ;
    rdfs:label "VSA-2 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005326
    obo:IAO_0000115 "VSA-1 is prepared by derivatizing a natural Momordica saponin in one chemical step. VSA-1 is chemically more stable than QS-21. VSA-1 is much less toxic than QS-21. The Momordica saponins are from sustainable sources and widely available." ;
    obo:IAO_0000116 """Pubmed References:
Chemical Nature: (1) Synthetic derivative of natural compound
Mechanism of Action: unknown
Immune profile induced: mixed Th1/Th2
Other Features/Characteristics: (1) synthetic saponin with lower toxicity and higher stability than QS21
By routes: SQ
Point of Contact: Pengfei Wang, University of Alabama
https://www.ncbi.nlm.nih.gov/pubmed/?term=31657920""" ;
    obo:IAO_0000117 "Pengfei Wang, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "VSA-1" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=41", "https://www.ncbi.nlm.nih.gov/pubmed/?term=31657920" ;
    obo:VO_0005328 41 ;
    a owl:Class ;
    rdfs:label "VSA-1 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005327
    obo:IAO_0000115 "rOv-ASP-1 stands for Recombinant Onchocerca volvulus activation-associated secreted protein-1. It is a potent adjuvant for antibody and cellular responses to protein, polypeptide and small peptide antigens. Onchocerca volvulus, the helminth parasite that causes onchocerciasis, known more commonly as river blindness." ;
    obo:IAO_0000116 """Pubmed References:
Chemical Nature: (1) Protein
Mechanism of Action: unknown
Immune profile induced: Th1
Other Features/Characteristics: (1) Induces CD8 T cells, (2) provides innate protection, (3) promotes antibody affinity maturation.
By routes: IM
Point of Contact: Sara Lustigman, New York Blood Center""" ;
    obo:IAO_0000117 "Sara Lustigman, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "Recombinant O. volvulus activation-associated secreted protein-1", "rOv-ASP-1" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=43", "https://www.ncbi.nlm.nih.gov/pubmed/?term=1583768", "https://www.ncbi.nlm.nih.gov/pubmed/?term=18341617", "https://www.ncbi.nlm.nih.gov/pubmed/?term=18675867", "https://www.ncbi.nlm.nih.gov/pubmed/?term=22615877", "https://www.ncbi.nlm.nih.gov/pubmed/?term=24681229", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25736195", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26795365", "https://www.ncbi.nlm.nih.gov/pubmed/?term=29764680", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32471056" ;
    obo:VO_0005328 43 ;
    a owl:Class ;
    rdfs:label "rOv-ASP-1 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005328
    obo:IAO_0000115 "An identifier assigned by the Vaccine Adjuvant Compendium (VAC: https://vac.niaid.nih.gov/)" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/" ;
    a owl:AnnotationProperty ;
    rdfs:label "VAC adjuvant ID"@en .

obo:VO_0005329
    obo:IAO_0000115 "double mutant of heat-labile E. coli toxin (LT) at R192G/L211A or LT(R192G/L211A)" ;
    obo:IAO_0000116 """Chemical Nature: protein
Mechanism of Action: CGM1 ganglioside, cAMP, inflammasome
Immune profile induced: mixed Th1/Th17
Other Features/Characteristics: Induces mucosal immunity (IM, ID, SQ, SL, oral, , transcutaneous), Induces epitope spreading, Promotes antibody affinity maturation, Effective in newborns, promotes antibody epitope spreading
By routes: IM, ID, SL, oral, SQ, IN, IP, intragastric, transcutaneous, transdermal, buccal, intrarectal
Point of Contact: Elizabeth Norton, Tulane University

https://www.ncbi.nlm.nih.gov/pubmed/?term=21288994
https://www.ncbi.nlm.nih.gov/pubmed/?term=6803349
https://www.ncbi.nlm.nih.gov/pubmed/?term=26540197
https://www.ncbi.nlm.nih.gov/pubmed/?term=4927082
https://www.ncbi.nlm.nih.gov/pubmed/?term=26305793
https://www.ncbi.nlm.nih.gov/pubmed/?term=25111827
https://www.ncbi.nlm.nih.gov/pubmed/?term=24453241
https://www.ncbi.nlm.nih.gov/pubmed/?term=22202122
https://www.ncbi.nlm.nih.gov/pubmed/?term=25803825
https://www.ncbi.nlm.nih.gov/pubmed/?term=23541621
https://www.ncbi.nlm.nih.gov/pubmed/?term=26018536
https://www.ncbi.nlm.nih.gov/pubmed/?term=5461379
https://www.ncbi.nlm.nih.gov/pubmed/?term=3578125
https://www.ncbi.nlm.nih.gov/pubmed/?term=5216441
https://www.ncbi.nlm.nih.gov/pubmed/?term=19897067
https://www.ncbi.nlm.nih.gov/pubmed/?term=25944298
https://www.ncbi.nlm.nih.gov/pubmed/?term=6424635
https://www.ncbi.nlm.nih.gov/pubmed/?term=3916310
https://www.ncbi.nlm.nih.gov/pubmed/?term=4826740
https://www.ncbi.nlm.nih.gov/pubmed/?term=2884428
https://www.ncbi.nlm.nih.gov/pubmed/?term=30778066
https://www.ncbi.nlm.nih.gov/pubmed/?term=4893257
https://www.ncbi.nlm.nih.gov/pubmed/?term=28063704
https://www.ncbi.nlm.nih.gov/pubmed/?term=4375349
https://www.ncbi.nlm.nih.gov/pubmed/?term=28792004
https://www.ncbi.nlm.nih.gov/pubmed/?term=25765967
https://www.ncbi.nlm.nih.gov/pubmed/?term=25483682
https://www.ncbi.nlm.nih.gov/pubmed/?term=30638799
https://www.ncbi.nlm.nih.gov/pubmed/?term=21326197
https://www.ncbi.nlm.nih.gov/pubmed/?term=31757774
https://www.ncbi.nlm.nih.gov/pubmed/?term=31427449
https://www.ncbi.nlm.nih.gov/pubmed/?term=6957164
https://www.ncbi.nlm.nih.gov/pubmed/?term=33465933
https://www.ncbi.nlm.nih.gov/pubmed/?term=33465933
https://www.ncbi.nlm.nih.gov/pubmed/?term=33465933
https://www.ncbi.nlm.nih.gov/pubmed/?term=31641151
https://www.ncbi.nlm.nih.gov/pubmed/?term=27133878
https://www.ncbi.nlm.nih.gov/pubmed/?term=27676456
https://www.ncbi.nlm.nih.gov/pubmed/?term=27226279
https://www.ncbi.nlm.nih.gov/pubmed/?term=22406456
https://www.ncbi.nlm.nih.gov/pubmed/?term=30787109
https://www.ncbi.nlm.nih.gov/pubmed/?term=24403527
https://www.ncbi.nlm.nih.gov/pubmed/?term=24403527
https://www.ncbi.nlm.nih.gov/pubmed/?term=30563789
https://www.ncbi.nlm.nih.gov/pubmed/?term=31757774
https://www.ncbi.nlm.nih.gov/pubmed/?term=30473185
https://www.ncbi.nlm.nih.gov/pubmed/?term=30248001
https://www.ncbi.nlm.nih.gov/pubmed/?term=24049109
https://www.ncbi.nlm.nih.gov/pubmed/?term=30797634
https://www.ncbi.nlm.nih.gov/pubmed/?term=31482013
https://www.ncbi.nlm.nih.gov/pubmed/?term=29771685
https://www.ncbi.nlm.nih.gov/pubmed/?term=31757774
https://www.ncbi.nlm.nih.gov/pubmed/?term=25444830

Clinical trials:
https://clinicaltrials.gov/ct2/show/NCT03922061
https://clinicaltrials.gov/ct2/show/NCT04232943
https://clinicaltrials.gov/ct2/show/NCT02531685
https://clinicaltrials.gov/ct2/show/NCT02052934
https://clinicaltrials.gov/ct2/show/NCT02531802
https://clinicaltrials.gov/ct2/show/NCT01147445
https://clinicaltrials.gov/ct2/show/NCT03548064
https://clinicaltrials.gov/ct2/show/ NCT01739231
https://clinicaltrials.gov/ct2/show/NCT03404674
https://clinicaltrials.gov/ct2/show/NCT03729219
https://clinicaltrials.gov/ct2/show/NCT04826094""" ;
    obo:IAO_0000117 "Elizabeth Norton, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "dmLT" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=13", "https://www.ncbi.nlm.nih.gov/pubmed/?term=19897067", "https://www.ncbi.nlm.nih.gov/pubmed/?term=21288994", "https://www.ncbi.nlm.nih.gov/pubmed/?term=22202122", "https://www.ncbi.nlm.nih.gov/pubmed/?term=23541621", "https://www.ncbi.nlm.nih.gov/pubmed/?term=24453241", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25111827", "https://www.ncbi.nlm.nih.gov/pubmed/?term=25803825", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26018536", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26305793", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26540197", "https://www.ncbi.nlm.nih.gov/pubmed/?term=3578125", "https://www.ncbi.nlm.nih.gov/pubmed/?term=4927082", "https://www.ncbi.nlm.nih.gov/pubmed/?term=5216441", "https://www.ncbi.nlm.nih.gov/pubmed/?term=5461379", "https://www.ncbi.nlm.nih.gov/pubmed/?term=6803349" ;
    obo:VO_0005328 13 ;
    a owl:Class ;
    rdfs:label "dmLT vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005313
    ] .

obo:VO_0005330
    obo:IAO_0000116 """Chemical Nature: (1) other (Peptide)
Mechanism of Action: C5aR1 on mononuclear phagocytes
Immune profile induced: mixed Th1/Th2
Other Features/Characteristics: (1) Induces CD8 T cells, (2) provides innate protection, (3) promotes antibody affinity maturation.
By routes: SQ, IP, IV.
Point of Contact: Joseph Vetro, University of Nebraska Medical Center
https://pubmed.ncbi.nlm.nih.gov/9013982/, https://pubmed.ncbi.nlm.nih.gov/9013982/, https://pubmed.ncbi.nlm.nih.gov/10516626/, https://pubmed.ncbi.nlm.nih.gov/10799917/, https://pubmed.ncbi.nlm.nih.gov/10799917/, https://pubmed.ncbi.nlm.nih.gov/12538044/, https://pubmed.ncbi.nlm.nih.gov/19428909/, https://pubmed.ncbi.nlm.nih.gov/21723901/""" ;
    obo:IAO_0000117 "Joseph Vetro, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "CPDI-01" ;
    obo:IAO_0000119 "https://pubmed.ncbi.nlm.nih.gov/10516626/", "https://pubmed.ncbi.nlm.nih.gov/10799917/", "https://pubmed.ncbi.nlm.nih.gov/12538044/", "https://pubmed.ncbi.nlm.nih.gov/19428909/", "https://pubmed.ncbi.nlm.nih.gov/21723901/", "https://pubmed.ncbi.nlm.nih.gov/9013982/", "https://vac.niaid.nih.gov/view?id=39" ;
    obo:VO_0005328 39 ;
    a owl:Class ;
    rdfs:label "CPDI-01 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005331
    obo:IAO_0000115 "A recombiant vector vaccine that is has a viral vector." ;
    dc:creator "Anthony Huffman" ;
    a owl:Class ;
    rdfs:label "recombinant viral vector vaccine"@en ;
    rdfs:subClassOf obo:VO_0000484 .

obo:VO_0005332
    obo:IAO_0000115 "A SARS-CoV-2 RNA vaccine by Arcturus Therapeutics, Inc." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05037097" ;
    a owl:Class ;
    rdfs:label "ARCT-165"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005333
    obo:IAO_0000115 "A SARS-CoV-2 monovalent protein subunit vaccine by Novavax immunizing against the B.1.351 (Beta) variant and containing the Matrix-M1 adjuvant" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05029856" ;
    a owl:Class ;
    rdfs:label "SII B.1.351"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005334
    obo:IAO_0000115 "A SARS-CoV-2 bivalent protein subunit vaccine by Novavax containing antigen for both the ancestral strain and B.1.351 (Beta) variant." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05029856" ;
    a owl:Class ;
    rdfs:label "SII Bivalent"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005335
    obo:IAO_0000115 "A SARS-CoV-2 monovalent protein subunit vaccine by Novavax immunizing against the B.1.617.2 (Delta) variant and containing the Matrix-M1 adjuvant" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05029856" ;
    a owl:Class ;
    rdfs:label "SII B.1.617.2"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005336
    obo:IAO_0000115 "A SARS-CoV-2 recombinant viral vector vaccine by Biocad" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05037188" ;
    a owl:Class ;
    rdfs:label "AAV5-RBD-S"@en ;
    rdfs:subClassOf obo:VO_0005199, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005337
    obo:IAO_0000115 "UM-3005 is a small molecule TLR7/8 agonist that can stimulate Th1-biased immune profile." ;
    obo:IAO_0000116 """Chemical Nature: (1) small molecule
Mechanism of Action: TLR7/8 agonist
Immune profile induced: Th1-biased
Route of immunization: IM
Point of Contact: Helene Bazin-Lee, InImmune""" ;
    obo:IAO_0000117 "Helene Bazin-Lee, Wolfgang Leitner, Oliver He, Ani M. Bernardi" ;
    obo:IAO_0000118 "UM-3005" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=47", "https://www.ncbi.nlm.nih.gov/pubmed/32210973" ;
    obo:VO_0005328 47 ;
    a owl:Class ;
    rdfs:label "UM-3005 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005272
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005306
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005338
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by Sinocelltech Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05043311" ;
    a owl:Class ;
    rdfs:label "SCTV01C"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005339
    obo:IAO_0000115 "A SARS-CoV-2 replication deficient human adenovirus vector vaccine expressing the spike, nucleocapsid and RNA polymerase proteins." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05094609" ;
    a owl:Class ;
    rdfs:label "Ad5-triCoV/Mac"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005340
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine developed by Vaccibody AS encoding the receptor-binding domain" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05069623" ;
    a owl:Class ;
    rdfs:label "VB10.2129"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005341
    obo:IAO_0000115 "A SARS-CoV-2 T-Cell-based DNA vaccine developed by Vaccibody AS" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05069623" ;
    a owl:Class ;
    rdfs:label "VB10.2210"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005342
    obo:IAO_0000115 "A SARS-CoV-2 replication deficient chimpanzee adenovirus 68 vector vaccine expressing the spike, nucleocapsid and RNA polymerase proteins." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05094609" ;
    a owl:Class ;
    rdfs:label "ChAd-triCoV/Mac"@en ;
    rdfs:subClassOf obo:VO_0005200, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000341
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005343
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by PT Bio Farma" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05067894" ;
    a owl:Class ;
    rdfs:label "COVID-19 subunit vaccine by PT Bio Farma"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005344
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine developed by Scancell Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05047445" ;
    a owl:Class ;
    rdfs:label "COVIDITY"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005345
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by Yisheng Biopharma" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "ACTRN12621001009808" ;
    a owl:Class ;
    rdfs:label "PIKA Recombinant COVID-19 Vaccine"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005346
    obo:IAO_0000115 "A SARS-CoV-2 DNA vaccine developed by University of Hong Kong and Immuno Cure 3 Limited" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05102643" ;
    a owl:Class ;
    rdfs:label "COVID-19 DNA vaccine by the University of Hong Kong and Immuno Cure 3 Limited"@en ;
    rdfs:subClassOf obo:VO_0005203, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005347
    obo:IAO_0000115 "A SARS-CoV-2 RNA vaccine by Arcturus Therapeutics, Inc." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "ISRCTN15779782" ;
    a owl:Class ;
    rdfs:label "ARCT-154"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000524 ;
        owl:someValuesFrom obo:PR_P0DTC2
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000530 ;
        owl:someValuesFrom obo:VO_0005179
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005348
    obo:IAO_0000115 "A COVID-19 virus-like particle vaccine developed by Yantai Patronus Biotech Co., Ltd." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05137444" ;
    a owl:Class ;
    rdfs:label "LYB001"@en ;
    rdfs:subClassOf obo:VO_0005205, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005349
    obo:IAO_0000115 "A SARS-CoV-2 inactivated vaccine developed by the National Research Centre of Egypt" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05128721" ;
    a owl:Class ;
    rdfs:label "Covi Vax"@en ;
    rdfs:subClassOf obo:VO_0005201, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000520 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_2697049
    ] .

obo:VO_0005350
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine containing a T-cell priming specific cocktail of Coronaviruses peptides mounted on a gold nanoparticle." ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05113862" ;
    a owl:Class ;
    rdfs:label "naNO-COVID"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000887
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005351
    obo:IAO_0000115 "A SARS-CoV-2 subunit vaccine by HK inno.N Corporation" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "NCT05113849" ;
    a owl:Class ;
    rdfs:label "IN-B009"@en ;
    rdfs:subClassOf obo:VO_0005202, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005352
    obo:IAO_0000115 "A SARS-CoV-2 RNA vaccine manufactured by VLP Therapeutics Japan, LLC" ;
    obo:IAO_0000117 "Philip Huang" ;
    obo:IAO_0000119 "jRCT2071210067" ;
    a owl:Class ;
    rdfs:label "VLPCOV-01"@en ;
    rdfs:subClassOf obo:VO_0005198, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000547 ;
        owl:someValuesFrom obo:VO_0000340
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ] .

obo:VO_0005353
    obo:IAO_0000115 "UM-3004 is a small molecule TLR7/8 agonist that can stimulate Th1-biased immune profile." ;
    obo:IAO_0000116 """Chemical Nature: (1) small molecule
Mechanism of Action: TLR7/8 agonist
Immune profile induced: Th1-biased
Route of immunization: IM
Point of Contact: Helene Bazin-Lee, University of Montana""" ;
    obo:IAO_0000117 "Helene Bazin-Lee, Wolfgang Leitner, Oliver He, Ani M. Bernardi" ;
    obo:IAO_0000118 "UM-3004" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=46", "https://www.ncbi.nlm.nih.gov/pubmed/32210973" ;
    obo:VO_0005328 46 ;
    a owl:Class ;
    rdfs:label "UM-3004 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005272
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005306
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005354
    obo:IAO_0000115 "UM-3003 is a small molecule TLR7/8 agonist that can stimulate Th1-biased immune profile." ;
    obo:IAO_0000116 """Chemical Nature: (1) small molecule
Mechanism of Action: TLR7/8 agonist
Immune profile induced: Th1-biased
Route of immunization: IM
Point of Contact: Helene Bazin-Lee, University of Montana""" ;
    obo:IAO_0000117 "Helene Bazin-Lee, Wolfgang Leitner, Oliver He, Ani M. Bernardi" ;
    obo:IAO_0000118 "UM-3003" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=45", "https://www.ncbi.nlm.nih.gov/pubmed/32210973" ;
    obo:VO_0005328 45 ;
    a owl:Class ;
    rdfs:label "UM-3003 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005272
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005306
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005355
    obo:IAO_0000115 "LTA1 is a vaccine adjuvant made from the A subunit of heat-labile (LT) enterotoxin of Enterotoxigenic Escherichia coli (ETEC). This LTA1 adjuvant is able to induce Th1, Th2, and Th17 immune responses." ;
    obo:IAO_0000116 """Chemical Nature: (1) Protein
Mechanism of Action: cAMP, inflammasome induction
Immune profile induced: mixed Th1/Th2/Th17
Other Features/Characteristics: (1) Induces mucosal immunity, (2) Induces epitope spreading, (3) Promotes antibody affinity maturation, (4) Promotes antibody epitope spreading, (5) High stability
Route of immunization: IM, IN, SL, ID, IP
Point of Contact: Elizabeth Norton, Tulane University""" ;
    obo:IAO_0000117 "Elizabeth Norton, Wolfgang Leitner, Oliver He, Ani M. Bernardi" ;
    obo:IAO_0000118 "LTA1" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=44", "https://www.ncbi.nlm.nih.gov/pubmed/22526674", "https://www.ncbi.nlm.nih.gov/pubmed/26305793", "https://www.ncbi.nlm.nih.gov/pubmed/31427449", "https://www.ncbi.nlm.nih.gov/pubmed/31641151", "https://www.ncbi.nlm.nih.gov/pubmed/31929548", "https://www.ncbi.nlm.nih.gov/pubmed/33986280", "https://www.ncbi.nlm.nih.gov/pubmed/34516780", "https://www.ncbi.nlm.nih.gov/pubmed/6957164" ;
    obo:VO_0005328 44 ;
    a owl:Class ;
    rdfs:label "LTA1 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005310
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005313
    ] .

obo:VO_0005356
    obo:IAO_0000115 "Glucan carbohydrate microcapsules with a β(1-3)/β(1-6) - linked glucan structure to allow targeting of antigens to macrophages or neutrophils through interactions with the β-glucan receptor found uniquely on the surface of these cell types. Adjuvax- ligand complexes are formed by physically entrapping or crosslinking the ligand within the β-glucan." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "DOI: 10.1021" ;
    a owl:Class ;
    rdfs:label "Adjuvax vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001359 .

obo:VO_0005357
    obo:IAO_0000115 "Advax-CpG is a combination adjuvant that includes an inulin-based polysaccharide (Advax) and a CpG oligodeoxynucleotide (ODN)" ;
    obo:IAO_0000116 """Pubmed References:Chemical Nature: (1) combination adjuvant
Mechanism of Action: (1) complement, (2) dendritic cells, (3) other/unknown, (4) TLR9 Immune profile induced: mixed Th1
Other Features/Characteristics: (1) induces CD8 T cells, (2) provides innate protection, (3) anti-inflammatory, (4) promotes antibody affinity maturation, (5) effective in newborns, (6) high stability
By routes: SQ, IM
Point of Contact: Nikolai Petrovsky, Vaxine LTD""" ;
    obo:IAO_0000117 "Nikolai Petrovsky, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "Advax-2", "Advax-SM" ;
    obo:IAO_0000119 "https://pubmed.ncbi.nlm.nih.gov/32636840/", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32849580", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33301675", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34069575" ;
    a owl:Class ;
    rdfs:label "Advax-CpG"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005358
    obo:IAO_0000115 "3-O-desacyl-4’-monophosphoryl lipid A (MPL) from Salmonella minnesota and a saponin molecule (QS-21) purified from plant extract Quillaja saponaria Molina, combined in a liposomal formulation consisting of dioleoyl phosphatidylcholine (DOPC) and cholesterol in phosphate-buffered saline solution." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/media/107538/download#:~:text=The%20AS01B%20adjuvant%20suspension%20is,DOPC)%20and%20cholesterol%20in%20phosphate%2D" ;
    a owl:Class ;
    rdfs:label "AS01B vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001354 .

obo:VO_0005359
    obo:IAO_0000115 "AS02A contains 50 ug MPL and 50ug QS21, 250uL of SB62 (oil/water emulsion) in phosphate buffered saline (PBS) per volume of 0.5 mL" ;
    obo:IAO_0000118 "As02a" ;
    obo:IAO_0000119 "https://clinicaltrials.gov/ct2/show/NCT00308061" ;
    a owl:Class ;
    rdfs:label "AS02A vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001264 .

obo:VO_0005360
    obo:IAO_0000115 "Aminoglycan consisting of β-(1→4)-linked D-glucosamine residues" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "CHEBI:16261, PMID: 24346613" ;
    a owl:Class ;
    rdfs:label "chitosan vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001359 .

obo:VO_0005361
    obo:IAO_0000115 "A water-dispersed liquid nanoparticle combined with an immuno-stimulating compound" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 " IMS 1313 N VGPR, IMS-1313" ;
    obo:IAO_0000119 "https://scialert.net/abstract/?doi=ijps.2018.167.174" ;
    a owl:Class ;
    rdfs:label "Montanide IMS 1313 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001271 .

obo:VO_0005362
    obo:IAO_0000115 "A water-dispersed liquid nanoparticle combined with an immuno-stimulating compound" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "ISA-206" ;
    obo:IAO_0000119 "PMID: 8961504" ;
    a owl:Class ;
    rdfs:label "Montanide ISA 206 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001271 .

obo:VO_0005363
    obo:IAO_0000115 "Mannide oleate derivative in a mineral oil solution ( Seppic SA, France)." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "ISA-50" ;
    obo:IAO_0000119 "http://vetarhiv.vef.unizg.hr/papers/74-2/raman.pdf" ;
    a owl:Class ;
    rdfs:label "Montanide ISA 50 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001271 .

obo:VO_0005364
    obo:IAO_0000115 "A steroid alkaloid that is tomatidine in which the hydroxy group at position 3 is linked to lycotetraose, a tetrasaccharide composed of two units of D-glucose, one unit of D-xylose, and one unit of D-galactose." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "CHEBI:9630" ;
    a owl:Class ;
    rdfs:label "Tomatine vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001359 .

obo:VO_0005365
    obo:IAO_0000115 "Polysaccharide prepared from the cell wall of Saccaromyces cerevisiae (bakers' yeast)" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "PMID: 11380697" ;
    a owl:Class ;
    rdfs:label "Zymosan vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001359 .

obo:VO_0005366
    obo:IAO_0000115 "oil-based adjuvant (Adjuvant XtendIII®; Grand Laboratories, Larchwood, IA)" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    a owl:Class ;
    rdfs:label "XtendIII vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0001355 .

obo:VO_0005367
    obo:IAO_0000115 "monophosphoryl lipid A (detoxified endotoxin) from S. minnesota (MPL) and synthetic trehalose dicorynomycolate (TDM) in 2% oil (squalene)-Tween 80-water." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "Monophosphoryl-lipid A + Trehalose dicorynomycolate" ;
    obo:IAO_0000119 "https://www.sigmaaldrich.com/US/en/product/sigma/m6536" ;
    a owl:Class ;
    rdfs:label "MPL + TDM vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000118 .

obo:VO_0005368
    obo:IAO_0000115 "A muramyl dipeptide derivative (threonyl-MDP) in an oil-in-water (o/w) emulsion vehicle." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "SAF" ;
    obo:IAO_0000119 "https://link.springer.com/protocol/10.1385/1-59259-083-7:229" ;
    a owl:Class ;
    rdfs:label "Syntex Adjuvant Formulation"@en ;
    rdfs:subClassOf obo:VO_0000187 .

obo:VO_0005369
    obo:IAO_0000115 "Diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "DBP" ;
    obo:IAO_0000119 "CHEBI:34687, PMID: 26319029" ;
    a owl:Class ;
    rdfs:label "dibutyl phthalate vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005313
    ] .

obo:VO_0005370
    obo:IAO_0000115 "A naturally occurring trivalent alcohol" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "glycerine, 1, 2, 3-propanetriol" ;
    obo:IAO_0000119 "https://academic.oup.com/cid/article/45/10/1277/277413" ;
    a owl:Class ;
    rdfs:label "glycerol vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005313
    ] .

obo:VO_0005371
    obo:IAO_0000115 "Three palmitic acid groups that are bound in an ester and amide linkage to a cysteine residue." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "Tripalmitoyl-S-glyceryl-cysteine" ;
    obo:IAO_0000119 "PMID: 24130558" ;
    a owl:Class ;
    rdfs:label "Pam3Cys vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005313
    ] .

obo:VO_0005372
    obo:IAO_0000115 "An equimolar mixture of the cationic lipid GAP-DMORIE [(±)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(cis-9-tetradecenyloxy)-1-propanaminium bromide)] and a neutral colipid DPyPE (1,2-diphytanoyl-sn-glydero-3-phosphoethanolamine)" ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "PMID: 21118032" ;
    a owl:Class ;
    rdfs:label "Vaxfectin vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005313
    ] .

obo:VO_0005373
    obo:IAO_0000115 "A vaccination process that involves adding a vaccine into a host prior to disease." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000118 "preventive vaccination" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Preventive_healthcare", "preventative vaccination" ;
    a owl:Class ;
    rdfs:label "prophylactic vaccination"@en ;
    rdfs:subClassOf obo:VO_0000002 .

obo:VO_0005374
    obo:IAO_0000115 "A vaccination process that involves adding a vaccine into a host after a disease has occurred." ;
    obo:IAO_0000117 "Randi Vita, Oliver He" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/Therapeutic_vaccines" ;
    a owl:Class ;
    rdfs:label "therapeutic vaccination"@en ;
    rdfs:subClassOf obo:VO_0000002 .

obo:VO_0005375
    obo:IAO_0000115 "T-vant is a vaccine adjuant that is derived from Salmonella enterica serovar typhimurium and is able to induce Th1/Th2/Th17 immune responses through the mechanism of action of TLR4, inflammasome, and DC activation." ;
    obo:IAO_0000116 """Chemical Nature: other
Mechanism of Action: TLR4; inflammasome; DC activation
Immune profile induced: Th1/Th2/Th17
Receptor: TLR4, NLRP3
Storage information: -20 or -80C
Point of Contact: Lisa Morici, Tulane University""" ;
    obo:IAO_0000117 "Lisa Morici, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "T-vant" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=61", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33498352", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34069796" ;
    obo:VO_0005328 61 ;
    a owl:Class ;
    rdfs:label "T-vant vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005304
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0005378
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005376
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005377 ;
        owl:someValuesFrom obo:PR_000001155
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005377 ;
        owl:someValuesFrom obo:PR_000011271
    ] .

obo:VO_0005376
    obo:IAO_0000115 "An immune profile that is characterized by the presense of Type 1 Type 2, and Th17 T helper cells." ;
    obo:IAO_0000117 "Oliver He, Amogh Madireddi" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/T_helper_cell", "https://pubmed.ncbi.nlm.nih.gov/10579123/" ;
    a owl:Class ;
    rdfs:label "Th1/Th2/Th17 mixed immune profile"@en ;
    rdfs:subClassOf obo:VO_0005308 .

obo:VO_0005377
    obo:IAO_0000112 "A vaccine adjuvant T-vant has molecular receptor of TLR4. Reference: https://vac.niaid.nih.gov/view?id=61." ;
    obo:IAO_0000115 "An object property that represents a relation between a material entity and a molecular entitiy that serves as the molecular receptor to the material entity." ;
    obo:IAO_0000117 "Oliver He" ;
    a owl:ObjectProperty ;
    rdfs:label "has molecular receptor"@en ;
    rdfs:subPropertyOf obo:RO_0002609 .

obo:VO_0005378
    obo:IAO_0000115 "A role of a material entity that binds to NLRP3." ;
    obo:IAO_0000117 "Oliver He" ;
    obo:IAO_0000119 "https://en.wikipedia.org/wiki/NLRP3" ;
    a owl:Class ;
    rdfs:label "NLRP3 receptor role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:VO_0005379
    obo:IAO_0000116 """Chemical Nature: Nucleic Acid
Mechanism of Action: TLR/RLR-agonist
Immune profile induced: Th1/Th2

Route of immunization: IM and IN
Point of Contact: Xiaoliang Ren, Yisheng Bio

Ongoing clinical trial:
https://clinicaltrials.gov/ct2/show/NCT02657161
https://clinicaltrials.gov/ct2/show/NCT02956421""" ;
    obo:IAO_0000117 "Xiaoliang Ren, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "PIKA" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=55", "https://www.ncbi.nlm.nih.gov/pubmed/?term=17484805", "https://www.ncbi.nlm.nih.gov/pubmed/?term=20538850", "https://www.ncbi.nlm.nih.gov/pubmed/?term=21468931", "https://www.ncbi.nlm.nih.gov/pubmed/?term=26765968", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28118938", "https://www.ncbi.nlm.nih.gov/pubmed/?term=29174316", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34766005" ;
    obo:VO_0005328 55 ;
    a owl:Class ;
    rdfs:label "PIKA vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005380
    obo:IAO_0000116 """Chemical Nature: peptide
Mechanism of Action: activation of mast cells, epithelial cells, macrophages and dendritic cells
Immune profile induced: Th2-biased

Route of immunization: IM and IN
Point of Contact: Herman Staats, Duke University""" ;
    obo:IAO_0000117 "Herman Staats, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "Mastoparan 7" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=53", "https://www.ncbi.nlm.nih.gov/pubmed/?term=31068425", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32047657", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34566991" ;
    obo:VO_0005328 53 ;
    a owl:Class ;
    rdfs:label "Mastoparan 7 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005310
    ] .

obo:VO_0005381
    obo:IAO_0000116 """Chemical Nature: small molecule
Mechanism of Action: mast cell activation
Immune profile induced: Th2-biased

Route of immunization: IN
Point of Contact: Herman Staats, Duke University""" ;
    obo:IAO_0000117 "Herman Staats, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "Mast cell activator small molecules" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=54", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34566991" ;
    obo:VO_0005328 54 ;
    a owl:Class ;
    rdfs:label "Mast cell activator small molecules vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005310
    ] .

obo:VO_0005382
    obo:IAO_0000116 """Chemical Nature: small molecule
Mechanism of Action: Innate Immune Activation
Immune profile induced: Th1-biased

Route of immunization: IM
Point of Contact: Ofer Levy, Precision Vaccines Program at Boston Children's Hospital""" ;
    obo:IAO_0000117 "Ofer Levy, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "Precision Vaccines Program (PVP)-037" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=56" ;
    obo:VO_0005328 56 ;
    a owl:Class ;
    rdfs:label "Precision Vaccines Program (PVP)-037 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005383
    obo:IAO_0000116 """Chemical Nature: small molecule
Mechanism of Action: TLR4 agonist
Immune profile induced: Th1/Th2

Route of immunization: IM and IN
Point of Contact: Robert Ernst, University of Maryland - Baltimore""" ;
    obo:IAO_0000117 "Robert Ernst, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "BECC470s" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=60" ;
    obo:VO_0005328 60 ;
    a owl:Class ;
    rdfs:label "BECC470s vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005311
    ] .

obo:VO_0005384
    obo:IAO_0000116 """Chemical Nature: small molecule
Mechanism of Action: innate immune activation
Immune profile induced: Th1-biased
Route of immunization: IM
Point of Contact: Helene Bazin-Lee, University of Montana""" ;
    obo:IAO_0000117 "Helene Bazin-Lee, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "TRAC478" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=48" ;
    obo:VO_0005328 48 ;
    a owl:Class ;
    rdfs:label "TRAC478 vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005385
    obo:IAO_0000116 """Chemical Nature: small molecule
Mechanism of Action: innate immune activation
Immune profile induced: Th1/Th17

Route of immunization: IM and IN
Point of Contact: Christopher Fox, AAHI""" ;
    obo:IAO_0000117 "Christopher Fox, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "GLA-3M-052-LS" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=58", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34248966", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34795290" ;
    obo:VO_0005328 58 ;
    a owl:Class ;
    rdfs:label "GLA-3M-052-LS vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005314
    ] .

obo:VO_0005386
    obo:IAO_0000116 """Chemical Nature: small molecule
Mechanism of Action: innate immune activation
Immune profile induced: Th1-biased

Route of immunization: IM
Point of Contact: Christopher Fox, AAHI""" ;
    obo:IAO_0000117 "Christopher Fox, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "3M-052-SE" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=57", "https://www.ncbi.nlm.nih.gov/pubmed/?term=28429728", "https://www.ncbi.nlm.nih.gov/pubmed/?term=30089691", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32213623", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34131024", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34972105", "https://www.ncbi.nlm.nih.gov/pubmed/?term=35572573" ;
    obo:VO_0005328 57 ;
    a owl:Class ;
    rdfs:label "3M-052-SE vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005387
    obo:IAO_0000116 """Chemical Nature: small molecule
Mechanism of Action: innate immune activation
Immune profile induced: Th1-biased

Route of immunization: IM
Point of Contact: Christopher Fox, AAHI

Clinical trials:
https://clinicaltrials.gov/ct2/show/NCT04177355
https://clinicaltrials.gov/ct2/show/NCT04915768
https://clinicaltrials.gov/ct2/show/NCT05197712""" ;
    obo:IAO_0000117 "Christopher Fox, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "3M-052-Alum" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=59", "https://www.ncbi.nlm.nih.gov/pubmed/?term=27847326", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32561559", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33971664", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34117252", "https://www.ncbi.nlm.nih.gov/pubmed/?term=34266981" ;
    obo:VO_0005328 59 ;
    a owl:Class ;
    rdfs:label "3M-052-Alum vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005388
    obo:IAO_0000116 """Chemical Nature: (1) emulsion
Mechanism of Action: unknown
Immune profile induced: Th1/Th17

Route of immunization: IM
Point of Contact: Patrice Dubois, Vaccine Formulation Institute

Clinical trial:
https://clinicaltrials.gov/ct2/show/NCT04702178""" ;
    obo:IAO_0000117 "Patrice Dubois, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "SWE" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=50", "https://www.ncbi.nlm.nih.gov/pubmed/?term=30849373", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32411401" ;
    obo:VO_0005328 50 ;
    a owl:Class ;
    rdfs:label "SWE vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005314
    ] .

obo:VO_0005389
    obo:IAO_0000116 """Chemical Nature: (1) Emulsion (with Saponin)
Mechanism of Action: unknown
Immune profile induced: Th1-biased

Route of immunization: IM
Point of Contact: Patrice Dubois, Vaccine Formulation Institute""" ;
    obo:IAO_0000117 "Patrice Dubois, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "SQ" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=52", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33688647" ;
    obo:VO_0005328 52 ;
    a owl:Class ;
    rdfs:label "SQ vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0005390
    obo:IAO_0000116 """Chemical Nature: (1) other (liposome with Saponin)
Mechanism of Action: unknown
Immune profile induced: Th1-biased

Route of immunization: IM
Point of Contact: Patrice Dubois, Vaccine Formulation Institute""" ;
    obo:IAO_0000117 "Patrice Dubois, Wolfgang Leitner, Oliver He" ;
    obo:IAO_0000118 "LQ" ;
    obo:IAO_0000119 "https://vac.niaid.nih.gov/view?id=51", "https://www.ncbi.nlm.nih.gov/pubmed/?term=32156809", "https://www.ncbi.nlm.nih.gov/pubmed/?term=33688647" ;
    obo:VO_0005328 51 ;
    a owl:Class ;
    rdfs:label "LQ vaccine adjuvant"@en ;
    rdfs:subClassOf obo:VO_0000580, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0005312 ;
        owl:someValuesFrom obo:VO_0005309
    ] .

obo:VO_0010632
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "country" ;
    rdfs:subClassOf obo:BFO_0000029 .

obo:VO_0010633
    obo:IAO_0000116 "USA is a country that exists in north America." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "USA" ;
    rdfs:subClassOf obo:VO_0010632 .

obo:VO_0010637
    obo:IAO_0000115 "A viral vaccine that protects against infection with Rubella virus." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "Rubella virus vaccine" ;
    rdfs:seeAlso "MeSH: D012411" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11041
            ]
        )
    ] .

obo:VO_0010702
    obo:IAO_0000115 "A vaccine regulation for vaccine safety." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "vaccine saftey regulation" ;
    rdfs:subClassOf obo:VO_0000683 .

obo:VO_0010704
    obo:IAO_0000115 "A vaccine regulatory process that is for vaccine regulatory agent to review vaccine license application from vaccine producer." ;
    obo:IAO_0000117 "YH" ;
    a owl:Class ;
    rdfs:label "review of vaccine license application" ;
    rdfs:subClassOf obo:VO_0000683 .

obo:VO_0010705
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins + Conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Actacel" ;
    rdfs:label "Actacel" ;
    rdfs:subClassOf obo:VO_0003168, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010706
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Avaxim" ;
    rdfs:label "Avaxim" ;
    rdfs:subClassOf obo:VO_0000646, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010707
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Avaxim - Pediatric" ;
    rdfs:label "Avaxim - Pediatric" ;
    rdfs:subClassOf obo:VO_0000646, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010708
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Live bacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: BCG Vaccine (Freeze-Dried)" ;
    rdfs:label "BCG Vaccine (Freeze-Dried) (by Sanofi Pasteur)" ;
    rdfs:subClassOf obo:VO_0000771, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010709
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins + killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: DT Polio Adsorbed" ;
    rdfs:label "DT Polio Adsorbed" ;
    rdfs:subClassOf obo:VO_0000943, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010710
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins + killed bacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Dukoral" ;
    rdfs:label "Dukoral" ;
    rdfs:subClassOf obo:VO_0000944, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000904 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:VO_0000908
    ] .

obo:VO_0010711
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm110102.htm" ;
    obo:VO_0003099 "ENGERIX-B" ;
    obo:VO_0003158 "Hepatitis B Vaccine (Recombinant)" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "ENGERIX-B is a vaccine indicated for immunization against infection caused by all known subtypes of hepatitis B virus." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224503.pdf" ;
    obo:VO_0003162 103239 ;
    a owl:Class ;
    rdfs:label "Engerix-B" ;
    rdfs:seeAlso "CVX: 08", "CVX: 44" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000940
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0004913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010712
    obo:IAO_0000115 "A Measles-Rubella vaccine that is live attenuated and manufactured by GlaxoSmithKline Biologicals." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Eolarix" ;
    rdfs:label "Eolarix" ;
    rdfs:subClassOf obo:VO_0000945, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_52071
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000926
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010713
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Epaxal" ;
    rdfs:label "Epaxal" ;
    rdfs:subClassOf obo:VO_0000646, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000576
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000687 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010714
    obo:IAO_0000116 """todo: assign parent
immunogen: TBE""" ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Inactivated whole virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: FSME - IMMUN" ;
    rdfs:label "FSME - IMMUN" ;
    rdfs:subClassOf obo:VO_0012190, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000927
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000937
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_17833
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000912
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000916
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000895 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010715
    obo:IAO_0000117 "Kallan Roan, Oliver He, ZX" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/683648", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm179527.htm" ;
    obo:VO_0003099 "HIBERIX" ;
    obo:VO_0003158 "Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)" ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals" ;
    obo:VO_0003160 "For active immunization for the prevention of invasive disease caused by Haemophilus influenzae type b. HIBERIX is approved for use in children 6 weeks through 4 years of age (prior to fifth birthday)." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf" ;
    obo:VO_0003198 683648 ;
    a owl:Class ;
    rdfs:label "Hiberix" ;
    rdfs:seeAlso "CVX: 48" ;
    rdfs:subClassOf obo:VO_0000662, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015014
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000625
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010716
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Imovax Polio" ;
    rdfs:label "Imovax Polio" ;
    rdfs:subClassOf obo:VO_0000664, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000921
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_17076
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010717
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Imovax Rabies" ;
    rdfs:label "Imovax Rabies (Canada)" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000926
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010718
    obo:IAO_0000115 "A poliovirus vaccine that uses poliovirus particles that have been grown under controlled conditions and then killed to prevent disease caused from the vaccine." ;
    obo:IAO_0000117 "Oliver He, Allen Xiang, Hector Guzman-Orozco" ;
    obo:IAO_0000232 "todo: Killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Inactived Poliomyelitis Vaccine - IPV" ;
    rdfs:label "Inactivated Poliomyelitis Vaccine - IPV" ;
    rdfs:subClassOf obo:VO_0000664, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000921
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010719
    obo:IAO_0000115 "A combination vaccine that protects infants from diphtheria, tetanus, pertussis (whooping cough), polio, hepatitis B and Haemophilus influenzae type b (Hib)." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000119 "http://www.immune.org.nz/vaccines/available-vaccines/infanrix-hexa" ;
    obo:IAO_0000232 "todo: Proteins + killed viruses + conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Infanrix-hexa" ;
    rdfs:label "Infanrix-hexa" ;
    rdfs:subClassOf obo:VO_0000946, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000929
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000940
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000137
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010720
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins + conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Infanrix/Hib" ;
    rdfs:label "Infanrix/Hib" ;
    rdfs:subClassOf obo:VO_0003168, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010721
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins + killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Infanrix-IPV" ;
    rdfs:label "Infanrix-IPV" ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010722
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins + killed virus + conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Infanrix -IPV/Hib" ;
    rdfs:label "Infanrix -IPV/Hib" ;
    rdfs:seeAlso "CVX: 120" ;
    rdfs:subClassOf obo:VO_0000744, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010723
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Liquid Pedvax HIB" ;
    rdfs:label "Liquid Pedvax HIB" ;
    rdfs:subClassOf obo:VO_0000662, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003049
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000695 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000896 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010724
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Meningitec" ;
    rdfs:label "Meningitec" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000687 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000905 ;
        owl:onProperty obo:VO_0000908
    ] .

obo:VO_0010725
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Polysaccharide"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Meningococcal Polysaccharide Vaccine, Groups A & C, Menomune A/C" ;
    rdfs:label "Meningococcal Polysaccharide Vaccine, Groups A & C, Menomune A/C" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010726
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Menjugate" ;
    rdfs:label "Menjugate" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000696 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010727
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Polysaccharide"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Menomune A/C/Y/W-135" ;
    rdfs:label "Menomune A/C/Y/W-135" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001256
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010728
    obo:IAO_0000115 "A live attenuated V. cholerae vaccine that is manufactured by Berna Biotech, Ltd. This vaccine uses the V. Cholera strain CVD 103-HGR." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Live bacteria"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Mutacol" ;
    rdfs:label "Mutacol" ;
    rdfs:subClassOf obo:VO_0000763, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_2877
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000939
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000687 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010729
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Neisvac-C" ;
    rdfs:label "Neisvac-C" ;
    rdfs:subClassOf obo:VO_0000053, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000895 ;
        owl:onProperty obo:OBI_0000304
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:VO_0000908
    ] .

obo:VO_0010730
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins, killed virus + conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Pediacel" ;
    rdfs:label "Pediacel" ;
    rdfs:subClassOf obo:VO_0000744, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000921
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_17076
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010731
    obo:IAO_0000115 "A polyvalent pneumococcal vaccine used to protectsagainst serious infection (e.g., meningitis, bacteria in the blood) due to Streptococcus pneumoniae, and it is manufactured by Sanofi Pasteur." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "PNEUMO (PNU-IMUNE)", "Pnu-Imune", "Pnu-Imune 23" ;
    obo:IAO_0000119 "https://www.webmd.com/drugs/2/drug-5547/pnu-imune-injection/details" ;
    a owl:Class ;
    rdfs:comment "Generic Name: pneumococcal vaccine polyvalent (Intramuscular route, Subcutaneous route)"^^xsd:string, "Trade Name: Pneumo 23" ;
    rdfs:label "Pneumo 23" ;
    rdfs:subClassOf obo:VO_0000424, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000888
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0001254
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010732
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Pneumovax 23" ;
    rdfs:label "Pneumovax 23 (Canada)" ;
    rdfs:subClassOf obo:VO_0000597, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000888
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000896 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010733
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000119 "https://www.prevnar13.com/" ;
    obo:IAO_0000232 "todo: Conjugate"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Prevnar" ;
    rdfs:label "Prevnar (Canada)" ;
    rdfs:subClassOf obo:VO_0000597, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000905 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010734
    obo:IAO_0000115 "A MMR vaccine that is manufactured by GlaxoSmithKline Biologicals." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Priorix" ;
    rdfs:label "Priorix" ;
    rdfs:subClassOf obo:VO_0000731, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010735
    obo:IAO_0000115 "A Measles-Mumps-Rubella-Vericella vaccine that is live attenuated and manufactured by GlaxoSmithKline Biologicals. " ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Priorix-Tetra" ;
    rdfs:label "Priorix-Tetra" ;
    rdfs:subClassOf obo:VO_0000737, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010736
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1607804" ;
    obo:IAO_0000232 "todo: Proteins + killed virus"^^xsd:string ;
    obo:VO_0003198 1607804 ;
    a owl:Class ;
    rdfs:comment "Trade Name: Quadracel" ;
    rdfs:label "Quadracel" ;
    rdfs:subClassOf obo:VO_0000742, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000920
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000924
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003201
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003202
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003384
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003455
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003835
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003836
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003837
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010737
    obo:IAO_0000117 "Kallan Roan, Oliver He" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm110098.htm" ;
    obo:IAO_0000232 "todo: Recombinant protein"^^xsd:string ;
    obo:VO_0003099 "RECOMBIVAX HB" ;
    obo:VO_0003158 "Hepatitis B Vaccine (Recombinant)" ;
    obo:VO_0003159 "Merck & Co, Inc" ;
    obo:VO_0003160 "RECOMBIVAX HB is indicated for vaccination against infection caused by all known subtypes of hepatitis B virus." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf" ;
    obo:VO_0003162 "BL 101066" ;
    a owl:Class ;
    rdfs:label "Recombivax HB" ;
    rdfs:seeAlso "CVX: 08", "CVX: 43", "CVX: 44" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000940
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000896 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010738
    obo:IAO_0000116 """todo: assign parent
immunogen: ROT""" ;
    obo:IAO_0000117 "Kallan Roan, Oliver He, ZX" ;
    obo:IAO_0000118 "ROTARIX" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm133920.htm"^^xsd:anyURI ;
    obo:IAO_0000232 "todo: Live virus"^^xsd:string ;
    obo:VO_0003099 "Rotarix"^^xsd:anyURI ;
    obo:VO_0003158 "Rotavirus Vaccine, Live, Oral"^^xsd:anyURI ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals"^^xsd:anyURI ;
    obo:VO_0003160 "For the prevention of rotavirus gastroenteritis caused by G1 and non-G1 types (G3, G4, and G9), for use in infants 6 weeks to 24 weeks of age."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125265"^^xsd:anyURI ;
    a owl:Class ;
    rdfs:label "Rotarix" ;
    rdfs:subClassOf obo:VO_0000658, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_52071
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000934
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000938
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0004815
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0003021
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010739
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Td Adsorbed" ;
    rdfs:label "Td Adsorbed" ;
    rdfs:subClassOf obo:VO_0000732, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010742
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Proteins"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Tripacel" ;
    rdfs:label "Tripacel" ;
    rdfs:subClassOf obo:VO_0000738, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000924
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010743
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Recombinant protein + killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Twinrix Junior" ;
    rdfs:label "Twinrix Junior" ;
    rdfs:subClassOf obo:VO_0000745, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000929
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000940
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010744
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Polysaccharide"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Typherix" ;
    rdfs:label "Typherix" ;
    rdfs:subClassOf obo:VO_0000671, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000888
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010745
    obo:IAO_0000117 "Kallan Roan, Oliver He, ZX" ;
    obo:IAO_0000118 "VAQTA" ;
    obo:IAO_0000119 "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm110017.htm" ;
    obo:IAO_0000232 "todo: Killed virus"^^xsd:string ;
    obo:VO_0003099 "VAQTA" ;
    obo:VO_0003158 "Hepatitis A Vaccine, Inactivated" ;
    obo:VO_0003159 "Merck & Co, Inc" ;
    obo:VO_0003160 "For active immunization against disease caused by hepatitis A virus in persons 12 months of age and older." ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf" ;
    obo:VO_0003162 "BL 103606" ;
    a owl:Class ;
    rdfs:comment "Trade Name: Vaqta" ;
    rdfs:label "Vaqta" ;
    rdfs:subClassOf obo:VO_0000646, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000920
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000931
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000896 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010746
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Live virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Varilrix" ;
    rdfs:label "Varilrix" ;
    rdfs:subClassOf obo:VO_0000419, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000926
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000173
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000913
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010747
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Live virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Varivax III" ;
    rdfs:label "Varivax III" ;
    rdfs:subClassOf obo:VO_0000419, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16199
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17992
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000921
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000922
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000931
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000896 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010748
    obo:IAO_0000116 "todo: assign parent immunogen: Typh-I + (HA)" ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Polysaccharide + killed virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: ViVaxim" ;
    rdfs:label "ViVaxim" ;
    rdfs:subClassOf obo:VO_0000950, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_16842
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000884
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000891
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000930
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:CHEBI_7507
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000699 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010749
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000232 "todo: Live virus"^^xsd:string ;
    a owl:Class ;
    rdfs:comment "Trade Name: Vivotif" ;
    rdfs:label "Vivotif (Canada)" ;
    rdfs:subClassOf obo:VO_0000671, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_17716
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:CHEBI_2877
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000531 ;
        owl:someValuesFrom obo:VO_0000915
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000687 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0010751
    obo:IAO_0000115 "a protein from a bacterium" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "bacterium protein" ;
    rdfs:subClassOf obo:PR_000000001 .

obo:VO_0010752
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "G+ bacterium protein" ;
    rdfs:subClassOf obo:VO_0010751 .

obo:VO_0010753
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "G- bacterium protein" ;
    rdfs:subClassOf obo:VO_0010751 .

obo:VO_0010754
    obo:IAO_0000115 "a protein from a virus" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "virus protein" ;
    rdfs:subClassOf obo:PR_000000001 .

obo:VO_0010755
    obo:IAO_0000115 "a protein from a parasite" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "parasite protein" ;
    rdfs:subClassOf obo:PR_000000001 .

obo:VO_0010756
    obo:IAO_0000115 "a protein from fungus" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "fungus protein" ;
    rdfs:subClassOf obo:PR_000000001 .

obo:VO_0010757
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bacillus anthracis protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0010758
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Brucella protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010759
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Yersinia pestis protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010760
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Francisella tularensis protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010761
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Ebola virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010762
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Clostridium botulinum  protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0010763
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Lassa Fever Virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010764
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Variola virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010765
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Campylobacter jejuni protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010766
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Escherichia coli protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010767
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Human Immunodeficiency Virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010768
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hantavirus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010769
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Marburg Virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010770
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Mycobacterium tuberculosis protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0010771
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Plasmodium spp. protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010772
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010773
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Coxiella burnetii protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010774
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "VEE Virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010775
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Clostridium tetani protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0010776
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Salmonella spp. protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010777
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Shigella protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010778
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010779
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Streptococcus pneumoniae protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0010780
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hepatitis A virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010781
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hepatitis B virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010782
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Influenza virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010783
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010784
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Measles virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010785
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Mumps virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010786
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010787
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Poliovirus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010788
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rabies virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010789
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rotavirus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010790
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rubella virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010791
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Yellow fever virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010792
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Varicella-zoster virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010793
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Tick-borne Encephalitis Virus (TBEV) protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010794
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Chlamydophila pneumoniae protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010795
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Chlamydia muridarum protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010796
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Yersinia pseudotuberculosis protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010797
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine Leukemia virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010798
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Corynebacterium diphtheriae protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0010799
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Porcine circovirus 2 protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010800
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Pseudorabies virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010801
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Classical swine fever virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010802
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010803
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "West Nile virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010804
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Marek's disease virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010805
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Newcastle disease virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010806
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Feline leukemia virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010807
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Canine parvovirus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010808
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Canine coronavirus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010809
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Canine distemper virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010810
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Infectious Hematopoietic Necrosis Virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010811
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Lawsonia intracellularis protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010812
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Porphyromonas gulae protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010813
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Yersinia ruckeri protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010814
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Aeromonas salmonicida protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010815
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Vibrio anguillarum (Listonella anguillarum) protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010816
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Streptococcus equi protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0010817
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Chlamydophila abortus protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010818
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Mycoplasma synoviae protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010819
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Mycoplasma gallisepticum protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010820
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bordetella avium protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010821
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Actinobacillus pleuropneumoniae protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010822
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Eimeria spp. protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010823
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Eimeria tenella protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010824
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Theileria parva protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010825
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Theileria annulata protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010826
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Toxoplasma gondii protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010827
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Babesia bovis protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010828
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Neospora caninum protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010829
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Giardia duodenalis protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010830
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Sarcocystis neurona protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010831
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Babesia canis protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010832
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Leishmania donovani protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010833
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Eimeria maxima protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010834
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 1 and 2 protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010835
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Leishmania major protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010836
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Leishmania infantum protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010837
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Leishmania amazonensis protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010838
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Trypanosoma cruzi protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010839
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Chlamydophila psittaci protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010840
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Burkholderia pseudomallei protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010841
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Western equine encephalomyelitis virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010842
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Cryptosporidium parvum protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010843
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hendra virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010844
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Dengue Virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010845
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Nipah virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010846
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rickettsia spp protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010847
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bordetella pertussis protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010848
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Vibrio cholerae protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010849
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rift Valley Fever virus protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010850
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "SARS-CoV protein" ;
    rdfs:subClassOf obo:VO_0010754 .

obo:VO_0010851
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Yersinia enterocolitica protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010852
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Entamoeba histolytica protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010853
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Coccidioides spp. protein" ;
    rdfs:subClassOf obo:VO_0010756 .

obo:VO_0010854
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Trypanosoma brucei protein" ;
    rdfs:subClassOf obo:VO_0010755 .

obo:VO_0010855
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Helicobacter pylori protein" ;
    rdfs:subClassOf obo:VO_0010753 .

obo:VO_0010856
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """IMMUNOGENICITY: Induces antigen-specific Th1 immune response, as indicated by the specific induction of serum IgG2a, but not IgG1, antibodies and by the secretion of IFN-alpha but not IL-4, by the Cu/Zn SOD-stimulated splenocytes. Has been used for vaccine development [PubMed: 10816475][PubMed: 11953393][PubMed: 12933826].    

MUTATION: An isogenic sodC mutant constructed from B abortus 2308 by gene replacement exhibited much greater susceptibility to killing by exogenous O(2)(-) than the parental 2308 strain, supporting a role for SodC in protecting this bacterium from O(2)(-) stress. The B abortus sodC mutant was much more sensitive to killing by cultured resident peritoneal macrophages from C57BL6J mice than 2308, and its attenuation in cultured murine macrophages was enhanced when these phagocytes were treated with gamma interferon. The attenuation of the B abortus sodC mutant in both resting and IFN-gamma-activated macrophages was alleviated in the presence of the NADPH oxidase inhibitor apocynin. Consistently, the B abortus sodC mutant also displayed significant attenuation in infected C57BL6J mice compared to the parental strain. These findings suggest that SodC protects B abortus 2308 from the respiratory burst of host macrophages [PubMed: 15845493].""" ;
    rdfs:label "SodC from B. abortus strain 2308" ;
    rdfs:seeAlso "VIOLILN Protegen ID: 3; NCBI Protein GI: 83269434; NCBI Protein Accession: YP_418725.1; NCBITaxon: 234" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010857
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Lef from B. anthracis str. A2012" ;
    rdfs:seeAlso "Protegen ID: 5; NCBI Gene GI: 1158731; NCBI Protein GI: 40646957; NCBI Protein Accession: AAR88323.1; NCBITaxon: 32630" ;
    rdfs:subClassOf obo:VO_0010757, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010858
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "EBOV GP" ;
    rdfs:seeAlso "Protegen ID: 10; NCBI Gene GI: 955190" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010859
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "EBOV NP" ;
    rdfs:seeAlso "Protegen ID: 11; NCBI Gene GI: 955194; NCBI Protein GI: 22789223; NCBI Protein Accession: NP_690580; NCBITaxon: 186539" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010860
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "VP24 from Reston ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 12; NCBI Gene GI: 955193; NCBI Protein GI: 22789228; NCBI Protein Accession: NP_690586; NCBITaxon: 186539" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010861
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "VP40 from Reston ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 13; NCBI Gene GI: 955192; NCBI Protein GI: 22789225; NCBI Protein Accession: NP_690582; NCBITaxon: 186539" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010862
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "VP30 from Reston ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 14; NCBI Gene GI: 955196; NCBI Protein GI: 22789227; NCBI Protein Accession: NP_690585; NCBITaxon: 186539" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010863
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "VP35 from Reston ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 15; NCBI Gene GI: 955189; NCBI Protein GI: 22789224; NCBI Protein Accession: NP_690581; NCBITaxon: 186539" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010864
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "VP35 expressed from alphavirus replicons induced a protective immune response in C57BL/6 mice when challenged with Ebola virus Zaire [PubMed: 11485406]." ;
    rdfs:label "VP35 from Zaire ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 16; NCBI Gene GI: 911827; NCBI Protein GI: 10313992; NCBI Protein Accession: NP_066244; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010865
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant Tbp1 and Tbp2 proteins were expressed from Escherichia coli and antisera were raised to the purified proteins. In a passive model of bacteraemia, infant rats were protected from challenge with Hib after transfer of anti-rTbp2 antiserum, but not after anti-rTbp1 antiserum [PubMed: 8830248]." ;
    rdfs:label "Tbp2" ;
    rdfs:seeAlso "Protegen ID: 277; NCBI Gene GI: 3430457; NCBI Protein GI: 68249580; NCBI Protein Accession: YP_248692; NCBITaxon: 281310" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010866
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "VP24 expressed from alphavirus replicons induced a protective immune response in BALB/c mice when challenged with Ebola virus Zaire [PubMed: 11485406]." ;
    rdfs:label "VP24 from Zaire ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 17; NCBI Gene GI: 911828; NCBI Protein GI: 10313998; NCBI Protein Accession: NP_066250; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010867
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "VP30 expressed from alphavirus replicons induced a protective immune response in BALB/c mice when challenged with Ebola virus Zaire [PubMed: 11485406]." ;
    rdfs:label "VP30 from Zaire ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 18; NCBI Gene GI: 911826; NCBI Protein GI: 10313997; NCBI Protein Accession: NP_066249; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010868
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """Vaccination of BALB/c or C57BL/6 mice with eVLPs, composed of the EBOV glycoprotein and matrix viral protein (VP)40 with a lipid membrane, in conjunction with QS-21 adjuvant resulted in mixed IgG subclass responses, a Th1-like memory cytokine response, and protection from lethal EBOV challenge [PubMed: 16002721].

VP40 expressed from alphavirus replicons induced a protective immune response in BALB/c mice when challenged with Ebola virus Zaire [PubMed: 11485406].""" ;
    rdfs:label "VP40 from Zaire ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 19; NCBI Gene GI: 911825; NCBI Protein GI: 10313993; NCBI Protein Accession: NP_066245; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010869
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "HLA-A*0201 mice immunized with either GPC(42-50) from LASVsSgp2 glycoprotein or GPC(60-68) were protected against challenge with a recombinant vaccinia virus that expressed LASV GPC [PubMed: 16912286]." ;
    rdfs:label "LASVsSgp2 glycoprotein" ;
    rdfs:seeAlso "Protegen ID: 20; NCBI Gene GI: 956585; NCBI Protein GI: 23343511; NCBI Protein Accession: NP_694870; NCBITaxon: 11620" ;
    rdfs:subClassOf obo:VO_0010763, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010870
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Caf1 from Y. pestis biovar Microtus str. 91001" ;
    rdfs:seeAlso "Protegen ID: 23; NCBI Gene GI: 2767670; NCBI Protein GI: 45478667; NCBI Protein Accession: NP_995523; NCBITaxon: 229193" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010871
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "It has previously been shown that a DNA subunit vaccine (4pox) based on four orthopoxvirus immunogens (L1R, B5R, A27L and A33R) can produce protective immunity against lethal orthopoxvirus challenges in mice and nonhuman primates. the immunogenicity of an L1R construct to which a tissue plasminogen activator signal sequence was placed in frame with the full-length L1R gene was tested. When the tPA-L1R construct was substituted for the unmodified L1R gene in the 4pox vaccine, given as a prime and single boost, animals were better protected from lethal challenge with vaccinia virus (VACV) [PubMed: 18485547]." ;
    rdfs:label "L1R from Monkeypox virus Zaire-96-I-16" ;
    rdfs:seeAlso "Protegen ID: 28; NCBI Gene GI: 928938; NCBI Protein GI: 17974998; NCBI Protein Accession: NP_536512; NCBITaxon: 619591" ;
    rdfs:subClassOf obo:VO_0010764, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010872
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "PagA from B. anthracis str. 'Ames Ancestor'" ;
    rdfs:seeAlso "Protegen ID: 32; NCBI Gene GI: 2820165; NCBI Protein GI: 47566476; NCBI Protein Accession: NC_007322.2" ;
    rdfs:subClassOf obo:VO_0010757, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010873
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Lef from B. anthracis str. Ames Ancestor'" ;
    rdfs:seeAlso "Protegen ID: 38; NCBI Gene GI: 2820148; NCBI Protein GI: 47566484; NCBI Protein Accession: NC_007322.2" ;
    rdfs:subClassOf obo:VO_0010757, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010874
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "MAb BA5 protected animals against plague, neutralized the Y. pestis type III secretion pathway and promoted opsonophagocytic clearance of bacteria in blood. LcrV residues 196-225 were necessary and sufficient for MAb BA5 binding.  These results identify LcrV residues 196-225 as a linear epitope that is recognized by the murine immune system to confer plague protection [PubMed: 20005318]." ;
    rdfs:label "LcrV from y. pestis CO92" ;
    rdfs:seeAlso "Protegen ID: 44; NCBI Gene GI: 1172676; NCBI Protein GI: 16082719; NCBI Protein Accession: NP_395165; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010875
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "An LcrV variant lacking amino acid residues 271 to 300 (rV10) elicited immune responses that protected mice against a lethal challenge with Y. pestis [PubMed: 16041032]." ;
    rdfs:label "LcrV from Y. pestis KIM 10" ;
    rdfs:seeAlso "Protegen ID: 45; NCBI Gene GI: 1149310; NCBI Protein GI: 31795491; NCBI Protein Accession: NP_857946; NCBITaxon: 187410" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010876
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "V antigen" ;
    rdfs:seeAlso "Protegen ID: 46; NCBI Gene GI: 4118094" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010877
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Results indicated that one of the predominant antibody response of mice surviving pneumonic plague after treatment with antibiotics was to pla [PubMed: 10085037]." ;
    rdfs:label "Pla" ;
    rdfs:seeAlso "Protegen ID: 48; NCBI Gene GI: 1172643; NCBI Protein GI: 16082686; NCBI Protein Accession: NP_395233; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010878
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The type III secretion apparatus encoded on the low-calcium response (LCR) virulence plasmid, pCD1 in strain KIM5, of Y. pestis is a conserved virulence mechanism that is absolutely required for virulence of Y. pestis. YscF is a surface localized protein required both to secrete Yops and to translocate toxins into eukaryotic cells. YscF polymerization is possibly required for a YscF needle to puncture eukaryotic cell membranes. It is also likely that YscF and its homologs function to provide a base that a translocon complex is built upon, or that YscF builds a conduit from the bacterium to the eukaryotic membrane - this suggestion seems more likely given that other proteins such as YopB, YopD, and LcrV are also required for translocation into eukaryotic cells. YscF is thought to be a surface-expressed protein in Y. pestis and is required for virulence. YscF has been found to function as a protective antigen against experimental plague infection [PubMed: 15978133]." ;
    rdfs:label "YopD from Y. pestis CO92" ;
    rdfs:seeAlso "Protegen ID: 49; NCBI Gene GI: 1172673; NCBI Protein GI: 16082716; NCBI Protein Accession: NP_395162; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010879
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system. Glu-tRNA Gln Amidotransferase (CP #3, gatA) was found to be protective.  Three of the clones (CP #1) elicited protection that was statistically higher than the unvaccinated control, which has high variance [PubMed: 15811648].

Note:  Part of CP #3 also belongs to gatB""" ;
    rdfs:label "GatA" ;
    rdfs:seeAlso "Protegen ID: 422; NCBI Protein GI: 62184918; NCBITaxon: 218497" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010880
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system. Glu-tRNA Gln Amidotransferase (CP #3, gatB) was found to be protective.  Three of the clones (CP #1) elicited protection that was statistically higher than the unvaccinated control, which has high variance [PubMed: 15811648].

Note:  Part of CP #3 also belongs to gatA""" ;
    rdfs:label "GatB" ;
    rdfs:seeAlso "Protegen ID: 424; NCBI Protein GI: 62147986; NCBITaxon: 218497" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010881
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The MOMP (omp1) DNA immunization induced a non-specific and partial protection in OF1 outbred mice fetuses against challenge with C. abortus [PubMed: 12488563]." ;
    rdfs:label "Omp1" ;
    rdfs:seeAlso "Protegen ID: 425; NCBI Protein GI: 40601; NCBITaxon: 83555" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010882
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In pregnant mice, the dnaK vaccine induced a non-specific partial protection from abortion after challenge with Chlamydophila abortus [PubMed: 12056482]." ;
    rdfs:label "DnaK" ;
    rdfs:seeAlso "Protegen ID: 426; NCBI Protein GI: 26006347; NCBITaxon: 83555" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010883
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The immunogenicity and protective effect of recombinant LcrE protein combined either with Freund's or Alum adjuvant were investigated in mice. The immunization with both protocols resulted in a significant reduction of the number of viable C. pneumoniae in the lungs after challenge. Results confirm that LcrE induces protective immunity in mice [PubMed: 19451031]." ;
    rdfs:label "LcrE" ;
    rdfs:seeAlso "Protegen ID: 428; NCBI Gene GI: 895078; NCBI Protein GI: 15618244; NCBI Protein Accession: NP_224529; NCBITaxon: 115713" ;
    rdfs:subClassOf obo:VO_0010794, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010884
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Results of this study showed that intranasal immunization of BALB/c mice with heat-aggregated CopN protein and an Escherichia coli heat-labile toxin (LT) induced a strong immune response.  The immunization induced statistically significant protection against intranasal C. pneumoniae challenge, the level of which correlated with the magnitude of CopN-specific lymphocyte proliferation [PubMed: 16949182]." ;
    rdfs:label "CopN" ;
    rdfs:seeAlso "Protegen ID: 429; NCBI Protein GI: 33241669; NCBITaxon: 182082" ;
    rdfs:subClassOf obo:VO_0010794, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010885
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following vaginal challenge with live Chlamydia, the groups of female BALB/c mice immunized intra-abdominally with TC0512 showed significant levels of protection when compared to negative control animals.  At 9 days following challenge TC0512 showed a 73% reduction in the number of recoverable Chlamydia compared with vector only immunized controls  [PubMed: 17239501]." ;
    rdfs:label "TC0512 outer membrane protein, putative" ;
    rdfs:seeAlso "Protegen ID: 430; NCBI Gene GI: 1245872; NCBI Protein GI: 15835130; NCBI Protein Accession: NP_296889; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010886
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following vaginal challenge with live Chlamydia, the groups of female BALB/c mice immunized intra-abdominally with TC0757 showed significant levels of protection when compared to negative control animals [PubMed: 17239501]." ;
    rdfs:label "TC0757 hypothetical protein" ;
    rdfs:seeAlso "Protegen ID: 431; NCBI Gene GI: 1246122; NCBI Protein GI: 15835371; NCBI Protein Accession: NP_297130; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010887
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following vaginal challenge with live Chlamydia, the groups of female BALB/c mice immunized intra-abdominally with TC0439 showed significant levels of protection when compared to negative control animals [PubMed: 17239501]." ;
    rdfs:label "TC0439 adherence factor" ;
    rdfs:seeAlso "Protegen ID: 432; NCBI Gene GI: 1245792; NCBI Protein GI: 15835057; NCBI Protein Accession: NP_296816; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010888
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following vaginal challenge with live Chlamydia, the groups of female BALB/c mice immunized intra-abdominally with TC0767/768 showed significant levels of protection when compared to negative control animals [PubMed: 17239501]." ;
    rdfs:label "TC0767 hypothetical protein" ;
    rdfs:seeAlso "Protegen ID: 433; NCBI Gene GI: 1246132; NCBI Protein GI: 15835381; NCBI Protein Accession: NP_297140; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010889
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following vaginal challenge with live Chlamydia, the groups of female BALB/c mice immunized intra-abdominally with TC0767/768 showed significant levels of protection when compared to negative control animals [PubMed: 17239501]." ;
    rdfs:label "TC0768 hypothetical protein" ;
    rdfs:seeAlso "Protegen ID: 434; NCBI Gene GI: 1246133; NCBI Protein GI: 15835382; NCBI Protein Accession: NP_297141; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010890
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Female BALB/c mice were immunized with chlamydial major outer membrane protein (MOMP) mixed with cholera toxin and CpG oligodeoxynucleotide adjuvants by either the IN or TCI routes.  Both intranasal and transcutaneous immunization protected mice against respiratory challenge with Chlamydia [PubMed: 16153755]." ;
    rdfs:label "MOMP" ;
    rdfs:seeAlso "Protegen ID: 435; NCBI Protein GI: 1518659; NCBITaxon: 83560" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010891
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with DCs transfected with individual Chlamydia protein PmpG-1(25-500), RplF, or PmpE/F-2(25-575) exhibited significant resistance to challenge infection.  Overall, vaccination with DCs transfected with PmpG-1(25-500) exhibited the greatest degree of protective immunity among the four Chlamydia Ags tested [PubMed: 19155509]." ;
    rdfs:label "PmpG-1" ;
    rdfs:seeAlso "Protegen ID: 436; NCBI Gene GI: 1246433; NCBI Protein GI: 15834883; NCBI Protein Accession: NP_296642; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010892
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with DCs transfected with individual Chlamydia protein PmpG-1(25-500), RplF, or PmpE/F-2(25-575) exhibited significant resistance to challenge infection.  In addition, RplF was able to engender protective immunity against challenge with C. muridarum [PubMed: 19155509]." ;
    rdfs:label "RplF" ;
    rdfs:seeAlso "Protegen ID: 437; NCBI Gene GI: 1246168; NCBI Protein GI: 15835415; NCBI Protein Accession: NP_297174; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010893
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with DCs transfected with individual Chlamydia protein PmpG-1(25-500), RplF, or PmpE/F-2(25-575) exhibited significant resistance to challenge infection.  In addition, pmpE/F-2 was able to engender protective immunity against challenge with C. muridarum [PubMed: 19155509]." ;
    rdfs:label "PmpE/F-2" ;
    rdfs:seeAlso "Protegen ID: 438; NCBI Gene GI: 1246432; NCBI Protein GI: 15834882; NCBI Protein Accession: NP_296641; NCBITaxon: 243161" ;
    rdfs:subClassOf obo:VO_0010795, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010894
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "IM-ID vaccination with CPn0095 (pknD) generated a response that resulted in moderately, but significantly reduced total C. pneumoniae lung loads as compared to control mice vaccinated with a plasmid expressing a non-Chlamydia ORF (p0.019).  This resulted in the ability of CPN0095 to mediate a moderate, but statistically significant level of protection in an inbred A/J mouse respiratory challenge model [PubMed: 16434129]." ;
    rdfs:label "PknD" ;
    rdfs:seeAlso "Protegen ID: 439; NCBI Gene GI: 895704; NCBI Protein GI: 161353778; NCBI Protein Accession: NP_224303; NCBITaxon: 115713" ;
    rdfs:subClassOf obo:VO_0010794, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010895
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "M-ID vaccination with fabD generated a response that resulted in moderately, but significantly reduced total C. pneumoniae lung loads as compared to control mice vaccinated with a plasmid expressing a non-Chlamydia ORF (p 0.019). This resulted in the ability of fabD to mediate a moderate, but statistically significant level of protection in an inbred A/J mouse respiratory challenge model [PubMed: 16434129]." ;
    rdfs:label "FabD" ;
    rdfs:seeAlso "Protegen ID: 440; NCBI Gene GI: 894994; NCBI Protein GI: 15618217; NCBI Protein Accession: NP_224502; NCBITaxon: 115713" ;
    rdfs:subClassOf obo:VO_0010794, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010896
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with candidate gene ssb showed significant reduction of spleen chlamydial loads as compared to nave, non-protected control mice (p 0.048).  This resulted in the ability of ssb to mediate a modest, but significant level of protection in an inbred A/J mouse respiratory challenge model [PubMed: 16434129]." ;
    rdfs:label "Ssb" ;
    rdfs:seeAlso "Protegen ID: 441; NCBI Gene GI: 894901; NCBI Protein GI: 15618301; NCBI Protein Accession: NP_224586; NCBITaxon: 115713" ;
    rdfs:subClassOf obo:VO_0010794, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010897
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """Pigs were subjected to challenge infection with a dose of 1x10(5)TCID(50) (50% tissue culture infective dose) virulent CSFV strain.  At 1 week post challenge infection, all of the yE2-immunized pigs were alive and without symptoms or signs of CSF.  The yeast-expressed E2 protein retains correct immunogenicity and is able to induce a protective immune response against CSFV infection [PubMed: 19625145].

In a seperate study, swine vaccinated with VVR expressing E0 and/or E2 resisted a lethal challenge infection with CSFV. Glycoprotein E0 represents a second determinant for the induction of protective immunity against classical swine fever [PubMed: 7666549].""" ;
    rdfs:label "E2" ;
    rdfs:seeAlso "Protegen ID: 442; NCBI Gene GI: 920146; NCBI Protein GI: 12657942; NCBI Protein Accession: NP_075354; NCBITaxon: 11096" ;
    rdfs:subClassOf obo:VO_0010801, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010898
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Swine vaccinated with VVR expressing E0 and/or E2 resisted a lethal challenge infection with CSFV. Glycoprotein E0 represents a second determinant for the induction of protective immunity against classical swine fever [PubMed: 7666549]." ;
    rdfs:label "E0" ;
    rdfs:seeAlso "Protegen ID: 443; NCBI Protein GI: 115343287; NCBITaxon: 11096" ;
    rdfs:subClassOf obo:VO_0010801, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010899
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intramuscular vaccination of pigs with immunoaffinity-purified E1 (gp55) in a double water-oil emulsion elicited high titers of neutralizing antibodies between 2 and 4 weeks after vaccination at the lowest dose tested (20 micrograms). The vaccinated pigs were completely protected against intranasal challenge with 100 50% lethal doses of HCV (Classical swine fever virus) strain Brescia [PubMed: 8350404]." ;
    rdfs:label "Gp55" ;
    rdfs:seeAlso "Protegen ID: 444; NCBI Protein GI: 1763691; NCBITaxon: 11096" ;
    rdfs:subClassOf obo:VO_0010801, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010900
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A single dose of ciBoNT/A1 HP provided equivalent or greater protective immunity, not only against the homologous toxin, but also against two distinct toxin subtypes with significant amino acid divergence in mice when challenged with BoNT/A subtypes /A1, /A2, and /A3 from Clostridium botulinum [PubMed: 19450643]." ;
    rdfs:label "BoNT/A1 from C. botulinum" ;
    rdfs:seeAlso "Protegen ID: 445; NCBI Protein GI: 241183337; NCBITaxon: 1491" ;
    rdfs:subClassOf obo:VO_0010762, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010901
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Purified FHc was used to vaccinate mice and evaluate their survival against challenge with active botulinum neurotoxin serotype F (BoNT/F).  Mice that received one injection of 5 microg or two injections of >or=0.04 microg of FHc were completely protected [PubMed: 18845829]." ;
    rdfs:label "FHc" ;
    rdfs:seeAlso "Protegen ID: 446; NCBI Protein GI: 166236883; NCBITaxon: 32630" ;
    rdfs:subClassOf obo:VO_0010762, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010902
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A completely synthetic gene encoding fragment C, a approximately 50-kDa fragment, of botulinum neurotoxin serotype A was constructed from oligonucleotides.  Mice given three subcutaneous vaccinations were protected against an intraperitoneal administration of 10^6 50% lethal doses (ID50) of serotype A toxin [PubMed: 7790092]." ;
    rdfs:label "BotA" ;
    rdfs:seeAlso "Protegen ID: 447; NCBI Protein GI: 733429; NCBITaxon: 32630" ;
    rdfs:subClassOf obo:VO_0010762, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010903
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice and rabbits were immunized with recombinant HCR/A1 (rHCR/A1) from the classical type A-Hall strain (ATCC 3502) (BoNT/A1) and rHCR/E from BoNT serotype E Beluga (BoNT/E(B)).  The protection elicited by rHCR/A1 to BoNT/A1 and BoNT/A2 and by rHCR/E(B) to BoNT/E(A) indicate that immunization with receptor binding domains elicit protection within sub-serotypes of BoNT [PubMed: 16177380]." ;
    rdfs:label "BoNT/A1 from C. botulinum A str. Hall" ;
    rdfs:seeAlso "Protegen ID: 448; NCBI Gene GI: 5398487; NCBI Protein GI: 153936924; NCBI Protein Accession: YP_001386738; NCBITaxon: 441771" ;
    rdfs:subClassOf obo:VO_0010762, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010904
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The DNA replicon vaccine (pSCARSBHc) encoding the Hc domain of BoNT/B (BHc) induced better responses and protection against BoNT/B mouse challenge than conventional DNA vaccine.  Recombinant SFV particle VRP-BHc protected mice from high-dose BoNT/B challenge [PubMed: 19712769]." ;
    rdfs:label "BoNT/B" ;
    rdfs:seeAlso "Protegen ID: 449; NCBI Gene GI: 6030102; NCBI Protein GI: 169834607; NCBI Protein Accession: YP_001693307; NCBITaxon: 498213" ;
    rdfs:subClassOf obo:VO_0010762, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010905
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers constructed a replication-incompetent adenovirus encoding a synthesized codon-optimized gene for expression of the heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C).  After a single dose of 2 x 10^7pfu adenoviral vectors in a mouse model, the animals were completely protected against intraperitoneal challenge with 100 x MLD(50) of active BoNT/C  [PubMed: 17897756]." ;
    rdfs:label "BoNT/C(Hc50)" ;
    rdfs:seeAlso "Protegen ID: 450; NCBI Protein GI: 217781; NCBI Protein Accession: BAA14235.1; NCBITaxon: 12336" ;
    rdfs:subClassOf obo:VO_0010762, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010906
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A recombinant vaccinia virus containing most of the P1 region of hepatitis A virus (HAV) was constructed bearing epitopes from structural polypeptides VP4, -3 and -2, and the N terminus of VP. Inoculation of tamarin monkeys with the recombinant virus resulted in the development of a specific anti-HAV immune response which was protective against challenge with a virulent strain of HAV [PubMed: 1654376]." ;
    rdfs:label "HAVgp2" ;
    rdfs:seeAlso "Protegen ID: 680; NCBI Gene GI: 1493919; NCBI Protein GI: 9626734; NCBI Protein Accession: NP_041008; NCBITaxon: 12092" ;
    rdfs:subClassOf obo:VO_0010780, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010907
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following two intragastric immunizations in BALB/c mice, the Yersinia vectors harboring a DNA vaccine encoding BFR (P39) induced antigen-specific serum immunoglobulin and Th1-type responses among splenocytes. The best protection was conferred by a serotype O:9 strain carrying pCIP39, confirming the importance of the P39 T-cell antigen in this mechanism [PubMed: 11895955]." ;
    rdfs:label "Bfr from B. abortus S19" ;
    rdfs:seeAlso "Protegen ID: 681; NCBI Gene GI: 6326162; NCBI Protein GI: 189022832; NCBI Protein Accession: YP_001932573; NCBITaxon: 430066" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010908
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study was designed to evaluate the immunogenicity and the protective efficacy of a divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal protein, rplL) and Omp16 protein (outer membrane lipoprotein). This divalent DNA vaccine induced a significant level of protection against challenge with the virulent B. abortus in BALB/c mice [PubMed: 16622210]." ;
    rdfs:label "RplL" ;
    rdfs:seeAlso "Protegen ID: 682; NCBI Gene GI: 3788918; NCBI Protein GI: 82700077; NCBI Protein Accession: YP_414651; NCBITaxon: 359391" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010909
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The fragment C of tetanus toxin was amplified from Clostridium tetani DNA by PCR.  Immunization of mice with rTTC resulted in the production of antibodies that were able to protect mice against a challenge with tetanus toxin furthermore, rTTC in vivo appeared to be able to undergo retrograde axonal transport [PubMed: 12075415]." ;
    rdfs:label "TTC" ;
    rdfs:seeAlso "Protegen ID: 451; NCBI Protein GI: 157829735; NCBITaxon: 1513" ;
    rdfs:subClassOf obo:VO_0010775, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010910
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Cynomolgus macaques were immunized with DNA/rAd5 vaccines expressing ZEBOV (GP) and SEBOV glycoprotein (GP) prior to lethal challenge with BEBOV. Vaccinated subjects developed robust, antigen-specific humoral and cellular immune responses against the GP from ZEBOV as well as cellular immunity against BEBOV GP, and immunized macaques were uniformly protected against lethal challenge with BEBOV [PubMed: 20502688]." ;
    rdfs:label "GP from Zaire ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 452; NCBI Gene GI: 911829; NCBI Protein GI: 10313995; NCBI Protein Accession: NP_066246; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010911
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Cynomolgus macaques were immunized with DNA/rAd5 vaccines expressing ZEBOV (GP) and SEBOV glycoprotein (GP) prior to lethal challenge with BEBOV. Vaccinated subjects developed robust, antigen-specific humoral and cellular immune responses against the GP from ZEBOV as well as cellular immunity against BEBOV GP, and immunized macaques were uniformly protected against lethal challenge with BEBOV [PubMed: 20502688]." ;
    rdfs:label "GP from Sudan ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 453; NCBI Gene GI: 3160774; NCBI Protein GI: 55770812; NCBI Protein Accession: YP_138523; NCBITaxon: 186540" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010912
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Guinea pigs infected with a single intranasal inoculation of HPIV3/EboGP-NP showed no apparent signs of disease yet developed a strong humoral response specific to the EV proteins. When these animals were challenged with an intraperitoneal injection of 10(3) PFU of EV, there were no outward signs of disease, no viremia or detectable EV antigen in the blood, and no evidence of infection in the spleen, liver, and lungs. In contrast, all of the control animals died or developed severe EV disease following challenge [PubMed: 16474134]." ;
    rdfs:label "NP" ;
    rdfs:seeAlso "Protegen ID: 454; NCBI Gene GI: 911830; NCBI Protein GI: 10314000; NCBI Protein Accession: NP_066243; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010761, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010913
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Ten mice were inoculated subcutaneously, administered booster injections after one month, and challenged with 130 LD(50) of wild type Y. pestis CO92.  The vaccinated animals produced high levels of specific antibodies against YscF as determined by Western blot. The data were statistically significant (P = 0.053 by two-tailed Fisher's test), suggesting that the YscF protein can provide a protective immune response against lethal plague challenge during subcutaneous plague infection [PubMed: 15939303]." ;
    rdfs:label "YscF from Y. pestis CO92" ;
    rdfs:seeAlso "Protegen ID: 54; NCBI Gene GI: 1172700; NCBI Protein GI: 16082743; NCBI Protein Accession: NP_395189; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010914
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The P4 protein is an integral outer membrane protein that has a role in acquiring hemin and nucleosides [PubMed: 1715322 ]." ;
    rdfs:label "P4" ;
    rdfs:seeAlso "Protegen ID: 100; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010915
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant P6 (pal) was capable of eliciting a protective antibody response against live H. influenzae type b challenge in a modified infant rat model of bacteremia [PubMed: 9261944]." ;
    rdfs:label "Pal" ;
    rdfs:seeAlso "Protegen ID: 101; NCBI Gene GI: 3429820; NCBI Protein GI: 68248984; NCBI Protein Accession: YP_248096; NCBITaxon: 281310" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010916
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "When mice immunized intranasally with recombinant protein corresponding to the C-terminal region of Hap(S) from H. influenzae strains N187, P860295, and TN106 plus mutant cholera toxin CT-E29H were challenged with strain TN106, they were protected against nasopharyngeal colonization [PubMed: 15557618]." ;
    rdfs:label "Hap from H. influenzae" ;
    rdfs:seeAlso "Protegen ID: 102; NCBI Protein GI: 21686508; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010917
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hap from H. influenzae" ;
    rdfs:seeAlso "Protegen ID: 103; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010918
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "OMP26 was used to immunize rats via intestinal Peyer's patches, followed by an intratracheal boost. Immunization was found to significantly enhance bacterial clearance following pulmonary challenge with both the homologous NTHI strain and a different NTHI strain [PubMed: 9573117]." ;
    rdfs:label "Omp26" ;
    rdfs:seeAlso "Protegen ID: 276; NCBI Nucleotide GI: 4574245; NCBI Protein GI: 4574246; NCBI Protein Accession: AAD23967.1; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010919
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The heterologous prime-boost strategy of live Salmonella vaccine expressing Mycobacterium tuberculosis fusion antigen Age5B-ESAT6 (esxA) from the chromosome followed by a systemic boost of antigen and adjuvant reduced the levels of M. tuberculosis bacteria in the lungs and spleen to the same extent as BCG. Additionally, this vaccination regimen was observed to be statistically equivalent in terms of protection to immunisation with BCG [PubMed: 19755145]." ;
    rdfs:label "EsxA" ;
    rdfs:seeAlso "Protegen ID: 104; NCBI Gene GI: 886209; NCBI Protein GI: 57117165; NCBI Protein Accession: NC_000962.2; NCBITaxon: 1773" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010920
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "TRAP from P. falciparum" ;
    rdfs:seeAlso "Protegen ID: 138; NCBI Gene GI: 814170; NCBI Protein GI: 124513464; NCBI Protein Accession: XP_001350088; NCBITaxon: 36329" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010921
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "LolC was evaluated as an antigen for a vaccine candidate against B. pseudomallei infection. Nonmembrane regions of the B. pseudomallei protein was expressed and purified from Escherichia coli and then evaluated as a vaccine candidate in an established mouse model of B. pseudomallei infection. When delivered with the monophosphoryl lipid A-trehalose dicorynomycolate adjuvant, the protein stimulated antigen-specific humoral and cellular immune responses. Immunization with the LolC protein domain afforded significant protection against a subsequent challenge with B. pseudomallei.  LolC provided a greater level of protection when it was administered with immune-stimulating complexes complexed with CpG oligodeoxynucleotide 10103. Immunization with LolC also protected against a subsequent challenge with a heterologous strain of B. pseudomallei, demonstrating the potential utility of this protein as a vaccine antigen for melioidosis [PubMed: 17517877]." ;
    rdfs:label "LolC/E" ;
    rdfs:seeAlso "Protegen ID: 768; NCBI Gene GI: 3093214; NCBI Protein GI: 53719887; NCBI Protein Accession: YP_108873; NCBITaxon: 272560" ;
    rdfs:subClassOf obo:VO_0010840, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010922
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "PotF was evaluated as an antigen for a vaccine candidate against B. pseudomallei infection. Nonmembrane regions of the B. pseudomallei protein was expressed and purified from Escherichia coli and then evaluated as a vaccine candidate in an established mouse model of B. pseudomallei infection. When delivered with the monophosphoryl lipid A-trehalose dicorynomycolate adjuvant, the protein stimulated antigen-specific humoral and cellular immune responses. Immunization with the PotF protein domain afforded significant protection against a subsequent challenge with B. pseudomallei [PubMed: 17517877]." ;
    rdfs:label "PotF" ;
    rdfs:seeAlso "Protegen ID: 769; NCBI Gene GI: 3095748; NCBI Protein GI: 53721504; NCBI Protein Accession: YP_110489; NCBITaxon: 272560" ;
    rdfs:subClassOf obo:VO_0010840, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010923
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "AMA1 from P. falciparum 3D7" ;
    rdfs:seeAlso "Protegen ID: 139; NCBI Gene GI: 810891; NCBI Protein GI: 124804478; NCBI Protein Accession: XP_001348015; NCBITaxon: 36329" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010924
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The ompA codon was adapted to the codon usage in birds, resulting in pcDNA1/MOMP(opt).  Researchers examined the capacity of nebulised or intramuscularly (IM) administered brPEI-pcDNA1/MOMP(opt) to induce a significant protective immune response in SPF turkeys experimentally infected with 10^8 TCID(50) of a virulent Cp. psittaci strain.  Vaccinated groups were significantly protected against Cp. psittaci challenge [PubMed: 20199760]." ;
    rdfs:label "OmpA from C. psittaci" ;
    rdfs:seeAlso "Protegen ID: 766; NCBI Protein GI: 94467392; NCBITaxon: 83554" ;
    rdfs:subClassOf obo:VO_0010839, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010925
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Plasmid DNA (pcDNA1::MOMP A) expressing the major outer membrane protein (MOMP) of Chlamydophila psittaci genotype A strain 89/1051 has been tested for its ability to induce protective immunity against Cp. psittaci challenge in budgerigars.  DNA immunisation significantly reduced clinical signs, macroscopic lesions, pharyngeal and cloacal excretion as well as chlamydial replication, even in the presence of pre-existing serum antibodies, as compared to the placebo-vaccinated controls [PubMed: 19640395]." ;
    rdfs:label "MOMP from C. psittaci" ;
    rdfs:seeAlso "Protegen ID: 767; NCBI Nucleotide GI: 144544; NCBI Protein GI: 144545; NCBI Protein Accession: AAA17396.1; NCBITaxon: 83554" ;
    rdfs:subClassOf obo:VO_0010839, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010926
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 11489167]" ;
    rdfs:label "ABRA" ;
    rdfs:seeAlso "Protegen ID: 137; NCBITaxon: 5835" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010927
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "This  gene was originally isolated from a lambda gt11 expression library probed with sera from Brucella-infected sheep. Sequence analysis of the cloned gene revealed the presence of an open reading frame of 158 amino acids encoding a protein of 17.3 kDa [PubMed: 7664168 ]. It was later identified as a cytoplasmic protein lumazine synthase [PubMed: 10482294 ]. This gene can be used for diagnosis [PubMed: 7664168 ] [PubMed: 10482294 ] and vaccine development [PubMed: 11953389 ]." ;
    rdfs:label "ORF" ;
    rdfs:seeAlso "Protegen ID: 113; NCBI Nucleotide GI: 599653; NCBI Protein GI: 599654; NCBI Protein Accession: CAA86936.1; NCBITaxon: 235" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010928
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. abortus strain 19 L7/L12" ;
    rdfs:seeAlso "Protegen ID: 114; NCBI Protein GI: 304271" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010929
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Guinea pigs were vaccinated with recombinant VEE replicons (packaged into VEE-like particles), inoculated with MBGV, and evaluated for viremia and survival after challenge with typical MGBV disease.  Results indicated that VP35 afforded incomplete protection [PubMed: 9813200 ]." ;
    rdfs:label "VP35" ;
    rdfs:seeAlso "Protegen ID: 167; NCBI Gene GI: 920948; NCBI Protein GI: 13489277; NCBI Protein Accession: NP_042026.1; NCBITaxon: 11269" ;
    rdfs:subClassOf obo:VO_0010769, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010930
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The purified recombinant proteins, P1, HspB, and P1-HspB, and whole-cell antigen (WCA) of C. burnetii were used to immunize BALB/c mice.  Protective immunity against Q fever was induced with a recombinant P1 antigen fused with HspB after Coxiella burnetii challenge [PubMed: 16481504 ]." ;
    rdfs:label "P1" ;
    rdfs:seeAlso "Protegen ID: 171; NCBI Protein GI: 30025845; NCBITaxon: 777" ;
    rdfs:subClassOf obo:VO_0010773, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010931
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "NP from Zaire ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 172; NCBI Gene GI: 911830; NCBI Protein GI: 10314000; NCBI Protein Accession: NP_066243; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010769, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010932
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "GP from Zaire ebolavirus" ;
    rdfs:seeAlso "Protegen ID: 173; NCBI Protein GI: 21702651; NCBITaxon: 186538" ;
    rdfs:subClassOf obo:VO_0010769, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010933
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "NP Marburgvirus - Ravn" ;
    rdfs:seeAlso "Protegen ID: 174; NCBI Protein GI: 91177744; NCBITaxon: 378809" ;
    rdfs:subClassOf obo:VO_0010769, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010934
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The purified recombinant proteins, P1, HspB, and P1-HspB, and whole-cell antigen (WCA) of C. burnetii were used to immunize BALB/c mice. Protective immunity against Q fever was induced with a recombinant P1 antigen fused with HspB after Coxiella burnetii challenge [PubMed: 16481504 ]." ;
    rdfs:label "HspB" ;
    rdfs:seeAlso "Protegen ID: 175; NCBI Protein GI: 197253489; NCBITaxon: 777" ;
    rdfs:subClassOf obo:VO_0010773, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010935
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were immunized with recombinant H3L protein to examine H3L-specific antibody responses in greater detail. H3L-immunized mice developed high-titer vaccinia virus-neutralizing antibodies (mean PRNT50 = 1:3,760). Importantly, H3L-immunized mice were subsequently protected against lethal intranasal challenges with 1 or 5 50% lethal doses (LD50) of pathogenic vaccinia virus strain WR, demonstrating the in vivo value of an anti-H3L response. To formally demonstrate that neutralizing anti-H3L antibodies are protective in vivo, we performed anti-H3L serum passive-transfer experiments. Mice receiving H3L-neutralizing antiserum were protected from a lethal challenge with 3 LD50 of vaccinia virus strain WR (5/10 versus 0/10; P < 0.02) [PubMed: 16140750]." ;
    rdfs:label "H3L" ;
    rdfs:seeAlso "Protegen ID: 62; NCBI Gene GI: 3707557; NCBI Protein GI: 66275898; NCBI Protein Accession: YP_232983; NCBITaxon: 10245" ;
    rdfs:subClassOf obo:VO_0010764, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010936
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Ag85A" ;
    rdfs:seeAlso "Protegen ID: 154; NCBITaxon: 1773" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010937
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Env Gp160" ;
    rdfs:seeAlso "Protegen ID: 153; NCBITaxon: 11676" ;
    rdfs:subClassOf obo:VO_0010767, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010938
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "StxB2" ;
    rdfs:seeAlso "Protegen ID: 225; NCBI Gene GI: 1262010; NCBI Protein GI: 9632507; NCBI Protein Accession: NP_049501; NCBITaxon: 10730" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010939
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Omp31" ;
    rdfs:seeAlso "Protegen ID: 231; NCBI Gene GI: 3788834; NCBI Protein GI: 82700421; NCBI Protein Accession: YP_414995; NCBITaxon: 359391" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010940
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Tir" ;
    rdfs:seeAlso "Protegen ID: 199; NCBI Gene GI: 960860; NCBI Protein GI: 15804222; NCBI Protein Accession: NP_290261.1; NCBITaxon: 562" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010941
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "ETEC also expresses a range of colonisation factor antigens (CFAs), which allow adherence to the mucosal surface and therefore colonisation of the intestine. Some CFAs are sub-divided into coli surface (CS) antigens [PubMed: 17566016]." ;
    rdfs:label "CS1" ;
    rdfs:seeAlso "Protegen ID: 79; NCBI Gene GI: 4188469; NCBI Protein GI: 110643341; NCBI Protein Accession: YP_671071; NCBITaxon: 362663" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010942
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "FlaA from C. jejuni NCTC 11168" ;
    rdfs:seeAlso "Protegen ID: 87; NCBI Gene GI: 905631; NCBI Protein GI: 15792662; NCBI Protein Accession: NP_282485.1; NCBITaxon: 197" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010943
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "LT is a hetero-oligomeric AB5 type enterotoxin composed of a 27 kDa A subunit with toxic ADP ribosyl transferase activity and a stable noncovalent-linked pentamer of 11.6 kDa B subunits. ETEC infection and colonization of the small intestine, and the production of LT, causes acute diarrhea that can be fatal without intervention [PubMed: 17188785]." ;
    rdfs:label "EltB" ;
    rdfs:seeAlso "Protegen ID: 92; NCBI Protein GI: 157021162; NCBITaxon: 562" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010944
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "EHEC strains produce intimin, an outer membrane adhesin encoded by the eae gene located in a chromosomal pathogenicity island termed the locus of enterocyte effacement [PubMed: 17258324]." ;
    rdfs:label "Eae" ;
    rdfs:seeAlso "Protegen ID: 93; NCBI Gene GI: 960862; NCBI Protein GI: 15804220; NCBI Protein Accession: NP_290259; NCBITaxon: 155864" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010945
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "FimH is a protective antigen [PubMed: 9110982]" ;
    rdfs:label "FimH from E. coli UTI89" ;
    rdfs:seeAlso "Protegen ID: 263; NCBI Gene GI: 3992235; NCBI Protein GI: 91213965; NCBI Protein Accession: YP_543951; NCBITaxon: 364106" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010946
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 10710308]." ;
    rdfs:label "GNA2132" ;
    rdfs:seeAlso "Protegen ID: 264; NCBI Gene GI: 903357; NCBI Protein GI: 15677945; NCBI Protein Accession: NP_275117; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010947
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 10710308]" ;
    rdfs:label "GNA2001" ;
    rdfs:seeAlso "Protegen ID: 265; NCBI Gene GI: 904124; NCBI Protein GI: 15677829; NCBI Protein Accession: NP_274993; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010948
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The 39-kDa protein is  immunogenic." ;
    rdfs:label "B. melitensis M5 P39" ;
    rdfs:seeAlso "Protegen ID: 110; NCBI Protein GI: 122892474; NCBI Protein Accession: ABM67295" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010949
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A novel primate lentivirus was identified in Mandrillus sphinx. One of the newly isolated SIV strains was intravenously inoculated into two rhesus macaques and resulted in chronic infection. These SIVs do not cluster with SIVmndGB1, the former representative strain of SIVmnd, but form a new, independent lineage. These results indicate that these SIVmnds are a novel type of SIVmnd and have infected Cameroonian mandrills for a long time. To date, M. sphinx is the only primate species other than humans that is naturally infected with two different types of SIV [PubMed: 11522184]." ;
    rdfs:label "Gag protein from SIV-mnd 2" ;
    rdfs:seeAlso "Protegen ID: 98; NCBI Gene GI: 956108; NCBITaxon: 159122" ;
    rdfs:subClassOf obo:VO_0010767, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010950
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination of mice and guinea pigs with a secA2 mutant significantly increased resistance to M. tuberculosis challenge compared with standard M. bovis bacille Calmette-Gurin vaccination [PubMed: 17671656]." ;
    rdfs:label "SecA2" ;
    rdfs:seeAlso "Protegen ID: 117; NCBI Gene GI: 885594; NCBI Protein GI: 15608958; NCBI Protein Accession: NP_216337; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010951
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The 10-kDa culture filtrate protein (CFP-10, esxB) and 6-kDa early secretory antigen of T cells (ESAT-6) are secreted in abundance by Mycobacterium tuberculosis.  Study demonstrated that protective immunity is induced by CFP-10 DNA vaccination in C3H mice as measured by a CFU reduction in the lung and spleen 4 and 8 weeks after challenge with M. tuberculosis [PubMed: 18332205]." ;
    rdfs:label "EsxB" ;
    rdfs:seeAlso "Protegen ID: 121; NCBI Gene GI: 886194; NCBI Protein GI: 15611010; NCBI Protein Accession: NP_218391; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010952
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers have developed DNA vaccines expressing M. tuberculosis antigen 85A (Ag85A, fbpA) and cytokine granulocyte macrophage colony stimulating factor (GM-CSF).  The immune strategy of BCG-prime and DNA vaccine boost induced mice to generate efficient immune protection against M. tuberculosis challenge [PubMed: 19450898]." ;
    rdfs:label "FbpA" ;
    rdfs:seeAlso "Protegen ID: 122; NCBI Gene GI: 886132; NCBI Protein GI: 15610940; NCBI Protein Accession: NC_000962.2; NCBITaxon: 1773" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010953
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "PepA" ;
    rdfs:seeAlso "Protegen ID: 123; NCBI Gene GI: 886924; NCBI Protein GI: 15607267; NCBI Protein Accession: NC_000962.2; NCBITaxon: 1773" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010954
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "PPE18" ;
    rdfs:seeAlso "Protegen ID: 124; NCBI Gene GI: 886073; NCBI Protein GI: 57116841; NCBI Protein Accession: NC_000962.2; NCBITaxon: 1773" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010955
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "CjaA from C. jejuni RM 1221" ;
    rdfs:seeAlso "Protegen ID: 133; NCBI Gene GI: 3231573; NCBI Protein GI: 57237809; NCBI Protein Accession: YP_179057.1; NCBITaxon: 197" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010956
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A total of 840 Light Sussex chickens were used to evaluate a Salmonella enterica serovar Typhimurium DeltaaroA vaccine  expressing the C. jejuni amino acid binding protein CjaA.  Chickens were given the vaccine at 1-day-old and two weeks later by oral gavage, then challenged after a further two weeks with C. jejuni. Across six biological replicates, statistically significant reductions in caecal C. jejuni of c. 1.4log(10) colony-forming units/g were observed at three and four weeks post-challenge relative to age-matched unvaccinated birds. Protection was associated with the induction of CjaA-specific serum IgY and biliary IgA [PubMed: 19853682]." ;
    rdfs:label "CjaA from C. jejuni" ;
    rdfs:seeAlso "Protegen ID: 134; NCBI Protein GI: 1813949; NCBITaxon: 197" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010957
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Pvs25" ;
    rdfs:seeAlso "Protegen ID: 141; NCBITaxon: 5855" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010958
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Aotus monkeys were challenged with the virulent Vietnam Oak Knoll (FVO) strain of P. falciparum.  Vaccination of A. nancymai with yMSP1(19) induced protective immune responses.  Both of the A. nancymai vaccinated with yMSP1(19) self-resolved an otherwise lethal infection [PubMed: 8529111]." ;
    rdfs:label "MSP1 from P. falciparum" ;
    rdfs:seeAlso "Protegen ID: 143; NCBI Protein GI: 94420988; NCBITaxon: 5833" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010959
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "RESA" ;
    rdfs:seeAlso "Protegen ID: 144" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010960
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study compared the immunogenicity and protective efficacy of recombinant DOBV nucleocapsid protein (rDOBV N, S) given with Alum or Freund's as adjuvant, or PBS, in C57/BL6 mice.   Mice receiving rDOBV N with Freund's adjuvant were protected from challenge (75% protected) [PubMed: 15364453]." ;
    rdfs:label "S nucleocapsid protein from Dobrava-Belgrade virus" ;
    rdfs:seeAlso "Protegen ID: 146; NCBI Gene GI: 2656266; NCBI Protein GI: 38505524; NCBI Protein Accession: NP_942553; NCBITaxon: 12506" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010961
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study developed replication-competent vaccines against EBOV and MARV based on attenuated recombinant vesicular stomatitis virus vectors expressing either the EBOV glycoprotein or MARV glycoprotein from Lake Victoria marburgvirus - Musoke. A single intramuscular injection of the EBOV or MARV vaccine elicited completely protective immune responses in nonhuman primates against lethal EBOV or MARV challenges [PubMed: 15937495]." ;
    rdfs:label "GP from Lake Victoria marburgvirus" ;
    rdfs:seeAlso "Protegen ID: 150; NCBI Protein GI: 77543430; NCBITaxon: 33727" ;
    rdfs:subClassOf obo:VO_0010769, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010962
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "This is a protective antigen [PubMed: 17239499]." ;
    rdfs:label "Bp26" ;
    rdfs:seeAlso "Protegen ID: 232; NCBI Gene GI: 1196247; NCBI Protein GI: 17986819; NCBI Protein Accession: NP_539453; NCBITaxon: 224914" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010963
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "RpsL" ;
    rdfs:seeAlso "Protegen ID: 236; NCBI Gene GI: 1196463; NCBI Protein GI: 161511151; NCBI Protein Accession: NP_539669; NCBITaxon: 224914" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010964
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Iss" ;
    rdfs:seeAlso "Protegen ID: 240; NCBI Gene GI: 5616654; NCBI Protein GI: 157418230; NCBI Protein Accession: YP_001481302; NCBITaxon: 405955" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010965
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "FyuA" ;
    rdfs:seeAlso "Protegen ID: 247; NCBI Gene GI: 4492541; NCBI Protein GI: 117624167; NCBI Protein Accession: YP_853080; NCBITaxon: 405955" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010966
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Brucella Omp25 is a protective antigen [PubMed: 17049676]." ;
    rdfs:label "Omp25" ;
    rdfs:seeAlso "Protegen ID: 253; NCBI Gene GI: 1196960; NCBI Protein GI: 17987532; NCBI Protein Accession: NP_540166; NCBITaxon: 224914" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010967
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Brucella IalB is a protective antigen [PubMed: 17049676]." ;
    rdfs:label "IalB" ;
    rdfs:seeAlso "Protegen ID: 254; NCBI Gene GI: 1197295; NCBI Protein GI: 17987867; NCBI Protein Accession: NP_540501; NCBITaxon: 224914" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010968
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Brucella bacterioferritin is a protective antigen [PubMed: 11447155 ]" ;
    rdfs:label "Bfr from B. melitensis biovar Abortus 2308" ;
    rdfs:seeAlso "Protegen ID: 255; NCBI Gene GI: 3828133; NCBI Protein GI: 83269559; NCBI Protein Accession: YP_418850; NCBITaxon: 359391" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010969
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "protective antigen [PubMed: 17239499]" ;
    rdfs:label "Tig" ;
    rdfs:seeAlso "Protegen ID: 256; NCBI Gene GI: 1196780; NCBI Protein GI: 17987352; NCBI Protein Accession: NP_539986; NCBITaxon: 224914" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010970
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Brucella DnaK is a protective antigen [PubMed: 17686554]." ;
    rdfs:label "DnaK" ;
    rdfs:seeAlso "Protegen ID: 257; NCBI Gene GI: 3341115; NCBI Protein GI: 62290965; NCBI Protein Accession: YP_222758; NCBITaxon: 262698" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010971
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Brucella SurA is a protective antigen [PubMed: 17686554]." ;
    rdfs:label "SurA" ;
    rdfs:seeAlso "Protegen ID: 258; NCBI Gene GI: 3787419; NCBI Protein GI: 82699574; NCBI Protein Accession: YP_414148; NCBITaxon: 359391" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010972
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Brucella Omp19 is a protective antigen [PubMed: 18981242]." ;
    rdfs:label "Omp19" ;
    rdfs:seeAlso "Protegen ID: 259; NCBI Gene GI: 3788831; NCBI Protein GI: 82700695; NCBI Protein Accession: YP_415269; NCBITaxon: 359391" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010973
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Brucella Omp16 is a protective antigen [PubMed: 18981242]." ;
    rdfs:label "Omp16" ;
    rdfs:seeAlso "Protegen ID: 260; NCBI Gene GI: 3788229; NCBI Protein GI: 82700483; NCBI Protein Accession: YP_415057; NCBITaxon: 359391" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010974
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 10710308]" ;
    rdfs:label "GNA1946" ;
    rdfs:seeAlso "Protegen ID: 266; NCBI Gene GI: 904205; NCBI Protein GI: 15677776; NCBI Protein Accession: NP_274940; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010975
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 10710308]" ;
    rdfs:label "GNA1220" ;
    rdfs:seeAlso "Protegen ID: 267; NCBI Gene GI: 903642; NCBI Protein GI: 15677093; NCBI Protein Accession: NP_274245; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010976
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen[PubMed: 10710308]" ;
    rdfs:label "GNA1162" ;
    rdfs:seeAlso "Protegen ID: 268; NCBI Gene GI: 903582; NCBI Protein GI: 15677037; NCBI Protein Accession: NP_274189; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010977
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 10710308]" ;
    rdfs:label "GNA992 (hsf)" ;
    rdfs:seeAlso "Protegen ID: 269; NCBI Gene GI: 903112; NCBI Protein GI: 15676883; NCBI Protein Accession: NP_274028; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010978
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 10710308]" ;
    rdfs:label "GNA33" ;
    rdfs:seeAlso "Protegen ID: 270; NCBI Gene GI: 902136; NCBI Protein GI: 15675973; NCBI Protein Accession: NP_273099; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010979
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 9104804]" ;
    rdfs:label "NspA from N. meningitidis MC58" ;
    rdfs:seeAlso "Protegen ID: 271; NCBI Gene GI: 902774; NCBI Protein GI: 15676561; NCBI Protein Accession: NP_273705; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010980
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 16825336][PubMed: 12045242] with GeneID: 902509. However, according to sequence analysis, this nadA is not the same NadA that was found to be protective antigen  [PubMed: 16825336][PubMed: 12045242]." ;
    rdfs:label "NadA" ;
    rdfs:seeAlso "Protegen ID: 272; NCBI Gene GI: 904134; NCBI Protein GI: 15677822; NCBI Protein Accession: NP_274986; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010981
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen [PubMed: 16825336]" ;
    rdfs:label "GNA1870" ;
    rdfs:seeAlso "Protegen ID: 273; NCBI Gene GI: 904318; NCBI Protein GI: 15677705; NCBI Protein Accession: NP_274866; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010982
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen as shown in some assays [PubMed: 16825336]" ;
    rdfs:label "GNA2091" ;
    rdfs:seeAlso "Protegen ID: 274; NCBI Gene GI: 903958; NCBI Protein GI: 15677911; NCBI Protein Accession: NP_275079; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010983
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective antigen as shown in some assays [PubMed: 16825336]" ;
    rdfs:label "GNA1030" ;
    rdfs:seeAlso "Protegen ID: 275; NCBI Gene GI: 903167; NCBI Protein GI: 15676917; NCBI Protein Accession: NP_274064; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010984
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A vaccine made by Hma from E. coli strain CFT073 and 536 induced protection to the infection of virulent  strain CFT073 and 536,  respectively, in the bladder in the CBA/J mice.  [PubMed: 19806177]." ;
    rdfs:label "Hma" ;
    rdfs:seeAlso "Protegen ID: 278; NCBI Gene GI: 1037732; NCBI Protein GI: 26248334; NCBI Protein Accession: NP_754374; NCBITaxon: 199310" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010985
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with IreA protects against urinary tract colinization by E.coli CFT073 and reduces colinization by E.coli 536 in the bladder of CBA/J mice [PubMed: 19806177]." ;
    rdfs:label "IreA" ;
    rdfs:seeAlso "Protegen ID: 279; NCBI Gene GI: 1037614; NCBI Protein GI: 26250982; NCBI Protein Accession: NP_757022; NCBITaxon: 199310" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010986
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with IutA protects against urinary tract colinization by E.coli CFT073 in the bladders of CBA/J mice [PubMed: 19806177]." ;
    rdfs:label "IutA" ;
    rdfs:seeAlso "Protegen ID: 280; NCBI Gene GI: 1039578; NCBI Protein GI: 26249458; NCBI Protein Accession: NP_755498; NCBITaxon: 199310" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010987
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Antibodies directed at the putative binding region of FimH (anti- s-FimH1-25) significantly reduced E. coli bladder infections in the experimental mouse model of urinary tract infections [PubMed: 9276729]." ;
    rdfs:label "FimH" ;
    rdfs:seeAlso "Protegen ID: 281; NCBI Gene GI: 948847; NCBI Protein GI: 16132141; NCBI Protein Accession: NP_418740; NCBITaxon: 511145" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010988
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Active immunization of BALB/c mice with IroN antigen in Freund's adjuvant protects mice from lethal challenge with ExPEC strain S26 [PubMed:  17145948 ]." ;
    rdfs:label "IroN" ;
    rdfs:seeAlso "Protegen ID: 282; NCBI Gene GI: 7379404; NCBI Protein GI: 222104801; NCBI Protein Accession: YP_002539290; NCBITaxon: 562" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010989
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Active immunization of BALB/c mice with C0393  antigen in Freund's adjuvant protects mice from lethal challenge with ExPEC strain S26 [PubMed: 17145948]." ;
    rdfs:label "C0393" ;
    rdfs:seeAlso "Protegen ID: 283; NCBI Gene GI: 1034958; NCBI Protein GI: 26246291; NCBI Protein Accession: NP_752330; NCBITaxon: 199310" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010990
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Active immunization of BALB/c mice with C4424 antigen in Freund's adjuvant protects mice from lethal challenge with ExPEC strain S26 [PubMed: 17145948]." ;
    rdfs:label "C4424" ;
    rdfs:seeAlso "Protegen ID: 284; NCBI Gene GI: 1038067; NCBI Protein GI: 26250246; NCBI Protein Accession: NP_756286; NCBITaxon: 199310" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010991
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Active immunization of BALB/c mice with recombinant E. coli protein C3389 antigen in Freund's adjuvant protects mice from lethal challenge with ExPEC strain S26 [PubMed: 17145948]." ;
    rdfs:label "C3389" ;
    rdfs:seeAlso "Protegen ID: 285; NCBI Gene GI: 1039252; NCBI Protein GI: 26249224; NCBI Protein Accession: NP_755264; NCBITaxon: 199310" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010992
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "S. flexneri M90T is a colonisation-defective mutant with a transposon in fnr, which encodes a regulator of anaerobic metabolism. To establish whether FNR-mediated repression of spa32 and spa33 contributes to increased Shigella entry into cells in an anaerobic cabinet, recombinant M90T strains were constructed which contain spa32 and spa33 under the control of either their native promoters (M90Tp32/33) or promoters with disrupted FNR boxes (M90Tp#32/#33).The presence in M90T of spa32 and spa33 alleles that are not repressed by FNR led to IpaB secretion during anaerobic growth, and loss of the increased entry of Shigella into cells in an anaerobic cabinet [PubMed: 20436458]." ;
    rdfs:label "Spa32" ;
    rdfs:seeAlso "Protegen ID: 288; NCBI Gene GI: 876502; NCBI Protein GI: 13449098; NCBI Protein Accession: NP_085314; NCBITaxon: 424718" ;
    rdfs:subClassOf obo:VO_0010777, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010993
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Oral immunization of FaeG-expressing L. lactis exhibits a protective response against ETEC infection in mice [PubMed: 19277476]." ;
    rdfs:label "ECSE_P3-0034" ;
    rdfs:seeAlso "Protegen ID: 289; NCBI Gene GI: 7003192; NCBI Protein GI: 209921909; NCBI Protein Accession: YP_002295988; NCBITaxon: 409438" ;
    rdfs:subClassOf obo:VO_0010766, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010994
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The invasiveness and virulence of Shigella spp. are largely due to the expression of plasmid-encoded virulence factors, among which are the invasion plasmid antigens (IpaB, IpaC, and IpaD). Recent observations have indicated that the Ipa proteins (IpaB, IpaC, and possibly IpaD) form a multiprotein complex capable of inducing the phagocytic event which internalizes the bacterium.  Researchers isolated a complex of invasins and LPS from water-extractable antigens of virulent shigellae.  Western blot analysis of the complex indicates that all of the major virulence antigens of Shigella, including IpaB, IpaC, and IpaD, and LPS are components of this macromolecular complex.  Guinea pigs (keratoconjunctivitis model) or mice (lethal lung model) immunized intranasally with purivied invasin complex (invaplex) on days 0, 14, and 28 and challenged 3 weeks later with virulent shigellae were protected from disease (P<0.01 for both animal models) [PubMed: 11083774]." ;
    rdfs:label "IpaB" ;
    rdfs:seeAlso "Protegen ID: 307; NCBI Protein GI: 22036246; NCBITaxon: 42897" ;
    rdfs:subClassOf obo:VO_0010777, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010995
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The invasiveness and virulence of Shigella spp. are largely due to the expression of plasmid-encoded virulence factors, among which are the invasion plasmid antigens (IpaB, IpaC, and IpaD). Recent observations have indicated that the Ipa proteins (IpaB, IpaC, and possibly IpaD) form a multiprotein complex capable of inducing the phagocytic event which internalizes the bacterium.  Researchers isolated a complex of invasins and LPS from water-extractable antigens of virulent shigellae.  Western blot analysis of the complex indicates that all of the major virulence antigens of Shigella, including IpaB, IpaC, and IpaD, and LPS are components of this macromolecular complex.  Guinea pigs (keratoconjunctivitis model) or mice (lethal lung model) immunized intranasally with purivied invasin complex (invaplex) on days 0, 14, and 28 and challenged 3 weeks later with virulent shigellae were protected from disease (P<0.01 for both animal models) [PubMed: 11083774]." ;
    rdfs:label "IpaC" ;
    rdfs:seeAlso "Protegen ID: 308; NCBI Protein GI: 47056; NCBITaxon: 42897" ;
    rdfs:subClassOf obo:VO_0010777, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010996
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The invasiveness and virulence of Shigella spp. are largely due to the expression of plasmid-encoded virulence factors, among which are the invasion plasmid antigens (IpaB, IpaC, and IpaD). Recent observations have indicated that the Ipa proteins (IpaB, IpaC, and possibly IpaD) form a multiprotein complex capable of inducing the phagocytic event which internalizes the bacterium.  Researchers isolated a complex of invasins and LPS from water-extractable antigens of virulent shigellae.  Western blot analysis of the complex indicates that all of the major virulence antigens of Shigella, including IpaB, IpaC, and IpaD, and LPS are components of this macromolecular complex.  Guinea pigs (keratoconjunctivitis model) or mice (lethal lung model) immunized intranasally with purivied invasin complex (invaplex) on days 0, 14, and 28 and challenged 3 weeks later with virulent shigellae were protected from disease (P<0.01 for both animal models) [PubMed: 11083774]." ;
    rdfs:label "IpaD" ;
    rdfs:seeAlso "Protegen ID: 309; NCBI Protein GI: 22036352; NCBITaxon: 42897" ;
    rdfs:subClassOf obo:VO_0010777, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010997
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Thirty-day-old chickens were immunized intramuscularly with purified IroN from Salmonella Typhimurium mixed with Freund's incomplete adjuvant; the chickens were then challenged intravenously with Salmonella Enteritidis. The mortality rate of immunized chickens was 10%. On the other hand, that of control chickens was 80% [PubMed: 20095157]." ;
    rdfs:label "IroN" ;
    rdfs:seeAlso "Protegen ID: 318; NCBI Protein GI: 259475459; NCBITaxon: 90371" ;
    rdfs:subClassOf obo:VO_0010776, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010998
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers evaluated the immunogenicity and protective efficacy of GroEL of Salmonella enterica serovar Typhi against lethal infection by S. typhi Ty2 in mice with or without adjuvants.  Immunization of mice with GroEL-alone, GroEL + alum, and GroEL + CFA provided 70, 50 and 80% protection, respectively, against lethal challenge by S. typhi in mice.  The present study shows that GroEL forms an ideal candidate molecule to develop a recombinant protein based vaccine against human typhoid [PubMed: 19851830]." ;
    rdfs:label "GroEL" ;
    rdfs:seeAlso "Protegen ID: 320; NCBI Gene GI: 1068458; NCBI Protein GI: 29144631; NCBI Protein Accession: NP_807973; NCBITaxon: 209261" ;
    rdfs:subClassOf obo:VO_0010776, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0010999
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The entire SopB and SifB genes were cloned into DNA vaccine vectors and were administered along with live attenuated Salmonella.  It was found that SopB vaccination reduced the bacterial burden of organs by about 5-fold on day 4 and day 8 after challenge with virulent Salmonella and proved to be a more efficient vaccination strategy than live attenuated bacteria alone [PubMed: 19428891]." ;
    rdfs:label "SopB" ;
    rdfs:seeAlso "Protegen ID: 321; NCBI Protein GI: 54036439; NCBITaxon: 90371" ;
    rdfs:subClassOf obo:VO_0010776, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011000
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Oral immunization of mice with ZJ111/pcDNA3-SAG1 elicited specific humoral responses and stimulated proliferation of splenocytes (P<0.05). Mice immunized with ZJ111/pcDNA3-SAG1 displayed significant protection against an intraperitoneally challenge with 500 tachyzoite forms of T. gondii RH strain. Vaccination at 10(7) and 10(8)CFU per mice provided a 20% and 10% survival rate comparing 100% mortality of the non-immunized mice, exhibiting longer living time and better survival rate [PubMed: 18590785]." ;
    rdfs:label "SAG1" ;
    rdfs:seeAlso "Protegen ID: 326; NCBI Gene GI: 7900172; NCBI Protein GI: 237839159; NCBI Protein Accession: XP_002368877; NCBITaxon: 508771" ;
    rdfs:subClassOf obo:VO_0010826, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011001
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Modified YscF antigens were able to partially protect immunized mice at various levels against lethal challenge with Y. pestis KIM 1001 strain [PubMed: 18291562]." ;
    rdfs:label "YscF from Y. pestis KIM 10" ;
    rdfs:seeAlso "Protegen ID: 338; NCBI Gene GI: 1149286; NCBI Protein GI: 31795470; NCBI Protein Accession: NP_857922; NCBITaxon: 187410" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011002
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Modified yopD antigens were able to partially protect immunized mice at various levels against lethal challenge with Y. pestis KIM 1001 strain [PubMed: 18291562]." ;
    rdfs:label "YopD from Y. pestis KIM 10" ;
    rdfs:seeAlso "Protegen ID: 339; NCBI Gene GI: 1149313; NCBI Protein GI: 31795494; NCBI Protein Accession: NP_857949; NCBITaxon: 187410" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011003
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Modified yopO antigens were able to partially protect immunized mice at various levels against lethal challenge with Y. pestis KIM 1001 strain [PubMed: 18291562]." ;
    rdfs:label "YopO" ;
    rdfs:seeAlso "Protegen ID: 340; NCBI Gene GI: 5798322; NCBI Protein GI: 162417777; NCBI Protein Accession: YP_001604502; NCBITaxon: 349746" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011004
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intranasal immunization with flagellin and the F1 antigen was protective against intranasal challenge with virulent Y. pestis CO92, with 93 to 100% survival of immunized mice. Lastly, vaccination of cynomolgus monkeys with flagellin and a fusion of the F1 and V antigens of Y. pestis induced a robust antigen-specific IgG antibody response [PubMed: 16428759]." ;
    rdfs:label "YPMT1.84 (F1 capsule antigen)" ;
    rdfs:seeAlso "Protegen ID: 341; NCBI Gene GI: 1172839; NCBI Protein GI: 16082876; NCBI Protein Accession: NP_395430; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011005
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse model, YPO0606 (yapF) partially protected mice from infection with Y. pestis at a high challenge dosage (200x LD(50)) [PubMed: 19651863]." ;
    rdfs:label "YapF" ;
    rdfs:seeAlso "Protegen ID: 342; NCBI Gene GI: 1173449; NCBI Protein GI: 218927800; NCBI Protein Accession: YP_002345675; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011006
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPO1914 (irp7) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "Irp7" ;
    rdfs:seeAlso "Protegen ID: 343; NCBI Gene GI: 1174753; NCBI Protein GI: 218929030; NCBI Protein Accession: YP_002346905; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011007
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPO0612 may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "YPO0612" ;
    rdfs:seeAlso "Protegen ID: 344; NCBI Gene GI: 1173455; NCBI Protein GI: 218927806; NCBI Protein Accession: YP_002345681; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011008
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPO3119 (htpG) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "HtpG" ;
    rdfs:seeAlso "Protegen ID: 345; NCBI Gene GI: 1175934; NCBI Protein GI: 218930152; NCBI Protein Accession: YP_002348027; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011009
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPO3047 (ydeN) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "YdeN" ;
    rdfs:seeAlso "Protegen ID: 346; NCBI Gene GI: 1175868; NCBI Protein GI: 218930092; NCBI Protein Accession: YP_002347967; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011010
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPO1377 (lolA) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "LolA" ;
    rdfs:seeAlso "Protegen ID: 347; NCBI Gene GI: 1174218; NCBI Protein GI: 218928525; NCBI Protein Accession: YP_002346400; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011011
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPCD1.05c (yerA) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "YerA" ;
    rdfs:seeAlso "Protegen ID: 348; NCBI Gene GI: 1172650; NCBI Protein GI: 16082696; NCBI Protein Accession: NP_395142; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011012
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPO0420 may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "YPO0420" ;
    rdfs:seeAlso "Protegen ID: 349; NCBI Gene GI: 1173265; NCBI Protein GI: 218927621; NCBI Protein Accession: YP_002345496; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011013
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using a mouse plague model, YPO3720 (hpmB) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis [PubMed: 19651863]." ;
    rdfs:label "HpmB" ;
    rdfs:seeAlso "Protegen ID: 350; NCBI Gene GI: 1176539; NCBI Protein GI: 218930726; NCBI Protein Accession: YP_002348601; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011014
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study tested the efficacy of 2 proteins, Psn and a portion of LcrV in protecting mice against virulent Yersinia pestis challenge.  Results show that the truncated LcrV protein delivered by RASV is sufficient to afford a full protective immune response in a mouse model of bubonic plague and the Psn protein afforded partial protection in a non-optimized system [PubMed: 17966435]." ;
    rdfs:label "Psn" ;
    rdfs:seeAlso "Protegen ID: 351; NCBI Gene GI: 1147351; NCBI Protein GI: 22126288; NCBI Protein Accession: NP_669711; NCBITaxon: 187410" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011015
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment.  Results indicated that one of the predominant antibody response of mice surviving pneumonic plague after treatment with antibiotics was to yopH [PubMed: 10085037]." ;
    rdfs:label "YopH from Y. pestis CO92" ;
    rdfs:seeAlso "Protegen ID: 352; NCBI Gene GI: 1172712; NCBI Protein GI: 16082755; NCBI Protein Accession: NP_395201; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011016
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Complexes of YopB (pYV0055), YopD, and YopE (BDE) secreted by Yersinia pseudotuberculosis were purified by affinity chromatography and used as immunogens to determine if antibodies to the translocon could provide protection against Y. pestis in mice. The YopB protein or a complex of YopB and YopD (BD) was purified and determined by vaccination to be immunogenic in mice. Mice actively vaccinated with BD or passively vaccinated with anti-BD serum were protected against lethal challenge with F1(-) Y. pestis [PubMed: 18765742]." ;
    rdfs:label "pYV0055" ;
    rdfs:seeAlso "Protegen ID: 354; NCBI Gene GI: 2952948; NCBI Protein GI: 51593897; NCBI Protein Accession: YP_068464; NCBITaxon: 273123" ;
    rdfs:subClassOf obo:VO_0010796, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011017
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination of mice with deF1 DNA conferred protection against subcutaneous infection with the virulent Y. pestis Kimberley53 strain, even at challenge amounts as high as 4,000 50% lethal doses [PubMed: 12496187 ]." ;
    rdfs:label "Caf1 from Y. pestis" ;
    rdfs:seeAlso "Protegen ID: 355; NCBI Protein GI: 48621; NCBITaxon: 632" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011018
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following passive immunization, antisera partially protected infant rats from bacteremia resulting from intraperitoneal challenge with bacteria. As assessed by immunoblotting, pooled adult human sera contained antibodies reactive with P145. Following passive immunization, these antisera partially protected infant rats from bacteremia resulting from intraperitoneal challenge with bacteria.  Antibody to P145 may contribute to protection against Brazilian purpuric fever [PubMed: 1937817]." ;
    rdfs:label "P145" ;
    rdfs:seeAlso "Protegen ID: 356" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011019
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The ApxI antigen is an important factor in the protection against Actinobacillus pleuropneumoniae serotype 5 infection; therefore, the protective immunity in mice following oral immunization with Saccharomyces cerevisiae expressing either ApxIA (group C) or ApxIIA (group D) alone or both (group E) was compared with that in two control groups (group A and B). The immunogenicity of the rApxIA antigen derived from the yeast was confirmed by a high survival rate and an ApxIA-specific IgG antibody response (p < 0.01) [PubMed: 17993753]." ;
    rdfs:label "ApxIA" ;
    rdfs:seeAlso "Protegen ID: 358; NCBI Protein GI: 312899; NCBITaxon: 715" ;
    rdfs:subClassOf obo:VO_0010821, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011020
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The levels of local and systemic antibodies specific to the Apx antigens were investigated in mice orally immunized with Apx antigen-expressing yeast.  Specific IgA responses to ApxIA or ApxIIA in the intestines and lungs from mice immunized with yeast expressing Apx antigens were significantly higher than those in the control groups after the second and third immunizations, respectively (p < 0.05).  All mice were monitored for up to 72 h after challenge with the MLD of an A. pleuropneumoniae field isolate. Overall, the final survival rates of the vaccinated groups were higher than those of the control groups at each time point [PubMed: 17993753]." ;
    rdfs:label "ApxIIA" ;
    rdfs:seeAlso "Protegen ID: 360; NCBI Protein GI: 52630374; NCBITaxon: 715" ;
    rdfs:subClassOf obo:VO_0010821, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011021
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following a booster vaccination, a significant (P < 0.05) IgG antibody response to the CP (cps5C), LPS, and HP was detected in the vaccinated pigs. The pigs vaccinated with the CP-HP and LPS-HP conjugates exhibited significantly less mortality (P < 0.05) and significantly greater weight gain (P < 0.001) than unvaccinated pigs. Vaccinated pigs exhibited significantly fewer and less extensive gross pulmonary lesions (P < 0.001) when compared with unvaccinated pigs [PubMed: 1455686]." ;
    rdfs:label "CP" ;
    rdfs:seeAlso "Protegen ID: 361" ;
    rdfs:subClassOf obo:VO_0010821, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011022
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following a booster vaccination, a significant (P < 0.05) IgG antibody response to the CP, LPS, and HP (APP7_1016) was detected in the vaccinated pigs. The pigs vaccinated with the CP-HP and LPS-HP conjugates exhibited significantly less mortality (P < 0.05) and significantly greater weight gain (P < 0.001) than unvaccinated pigs. Vaccinated pigs exhibited significantly fewer and less extensive gross pulmonary lesions (P < 0.001) when compared with unvaccinated pigs [PubMed: 1455686]." ;
    rdfs:label "APP7_1016" ;
    rdfs:seeAlso "Protegen ID: 362; NCBI Gene GI: 6398034; NCBI Protein GI: 190150285; NCBI Protein Accession: YP_001968810; NCBITaxon: 537457" ;
    rdfs:subClassOf obo:VO_0010821, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011024
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The aroA gene of A. salmonicida was cloned in Escherichia coli, and the nucleotide sequence was determined.  Vaccination of brown trout with 10(7) CFU of A. salmonicida 644Rb aroA by intraperitoneal injection resulted in a 253-fold increase in the 50% lethal dose (LD50) compared with unvaccinated controls challenged with a virulent clinical isolate 9 weeks later [PubMed: 8478107]." ;
    rdfs:label "AroA" ;
    rdfs:seeAlso "Protegen ID: 366; NCBI Protein GI: 512545; NCBITaxon: 645" ;
    rdfs:subClassOf obo:VO_0010814, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011025
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Passive immunisation of Atlantic salmon with rainbow trout or rabbit anti-AsaP1 antisera conferred significant protection against challenge with a virulent A. salmonicida [Ref1011:Gudmundsdottir et al., 1997]" ;
    rdfs:label "AsaP1" ;
    rdfs:seeAlso "Protegen ID: 367; NCBI Gene GI: 4998702; NCBITaxon: 382245" ;
    rdfs:subClassOf obo:VO_0010814, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011026
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "RAP-1 (21B4) is a candidate for inclusion in a B. bovis vaccine based on its ability to induce partial protection in vaccinates, defined as a significant reduction in parasitemia upon challenge [PubMed: 1441189]." ;
    rdfs:label "RAP-1" ;
    rdfs:seeAlso "Protegen ID: 368; NCBI Gene GI: 5479143; NCBI Protein GI: 156087004; NCBI Protein Accession: XP_001610909; NCBITaxon: 484906" ;
    rdfs:subClassOf obo:VO_0010827, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011027
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Crude extracts of Babesia bovis parasites were systematically fractionated and tested in numerous sequential vaccination/challenge experiments in adult cattle.  Two of these, GST-12D3 and GST-11C5, when used in combination were almost as protective as has been previously shown for the commercially available live attenuated vaccine [PubMed: 1441189]." ;
    rdfs:label "12D3" ;
    rdfs:seeAlso "Protegen ID: 371; NCBI Gene GI: 5478971; NCBI Protein GI: 156086656; NCBI Protein Accession: XP_001610737; NCBITaxon: 484906" ;
    rdfs:subClassOf obo:VO_0010827, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011028
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Crude extracts of Babesia bovis parasites were systematically fractionated and tested in numerous sequential vaccination/challenge experiments in adult cattle. A short fragment of the third antigen (21B4) has been shown to be protective [PubMed: 1441189]." ;
    rdfs:label "21B4" ;
    rdfs:seeAlso "Protegen ID: 373; NCBI Protein GI: 1246924; NCBITaxon: 5865" ;
    rdfs:subClassOf obo:VO_0010827, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011029
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study described the construction and evaluation of an adenovirus vaccine expressing domain 4 of Bacillus anthracis protective antigen, Ad.D4. Ad.D4 elicited antibodies to protective antigen 14 days after a single intramuscular injection, which were further increased upon boosting. Furthermore, two doses of Ad.D4 4 weeks apart were sufficient to protect 67% of mice from toxin challenge [PubMed: 16428747]." ;
    rdfs:label "PagA from B. anthracis" ;
    rdfs:seeAlso "Protegen ID: 374; NCBI Protein GI: 9280533; NCBITaxon: 1392" ;
    rdfs:subClassOf obo:VO_0010757, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011030
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A combination of the 69-kDa outer membrane protein and filamentous hemagglutinin (fhaB), both isolated from lymphocytosis promoting factor (LPF; pertussis toxin) minus mutants of Bordetella pertussis, is protective in the mouse intracerebral challenge potency (Kendrick) test [PubMed: 2056199]." ;
    rdfs:label "FhaB" ;
    rdfs:seeAlso "Protegen ID: 375; NCBI Protein GI: 3980256; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011031
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A study demonstrated that passive immunization with specific anti-B. pertussis adenylate cyclase antibodies or active immunization with purified B. pertussis secreted adenylate cyclase (cyaA) protect mice against a lethal respiratory challenge with B. pertussis or B. parapertussis. Results suggest that adenylate cyclase might be the primary cytotoxin responsible for mouse pulmonary lesions during respiratory tract infection with B. pertussis or with the related species B. parapertussis and is a protective antigen of B. pertussis [PubMed: 2622329]." ;
    rdfs:label "CyaA" ;
    rdfs:seeAlso "Protegen ID: 376; NCBI Protein GI: 580668; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011032
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model.  These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge [PubMed: 12117973]." ;
    rdfs:label "PtxD" ;
    rdfs:seeAlso "Protegen ID: 377; NCBI Protein GI: 225311181; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011033
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers constructed isogenic mutants of B. pertussis Tohama expressing the alleles ptxA1 or ptxA2 and prn1 or prn2 and compared the efficacies of an acellular pertussis vaccine against the mutants in a mouse model. While the vaccine was effective against all of the B. pertussis strains regardless of the allele expression pattern, the strain expressing ptxA1 and prn2 displayed a survival advantage over the other strains [PubMed: 20357056]." ;
    rdfs:label "Prn" ;
    rdfs:seeAlso "Protegen ID: 378; NCBI Gene GI: 2664290; NCBI Protein GI: 33592195; NCBI Protein Accession: NP_879839; NCBITaxon: 257313" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011034
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model.  These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge [PubMed: 12117973]." ;
    rdfs:label "PtxA" ;
    rdfs:seeAlso "Protegen ID: 379; NCBI Gene GI: 2665068; NCBI Protein GI: 33594638; NCBI Protein Accession: NP_882282; NCBITaxon: 257313" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011035
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73 kDa N-terminal alpha-domain of BrkA autotransporter protein and the Cpn60/60 kDa chaperonin. Both stimulated antibodies against pertussis and induced a 42% protection rate against the challenge [PubMed: 17011680]." ;
    rdfs:label "Cpn60" ;
    rdfs:seeAlso "Protegen ID: 382; NCBI Protein GI: 968920; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011036
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73 kDa N-terminal alpha-domain of BrkA autotransporter protein and the Cpn60/60 kDa chaperonin. Both stimulated antibodies against pertussis and induced a 42% protection rate against the challenge [PubMed: 17011680]." ;
    rdfs:label "BrkA" ;
    rdfs:seeAlso "Protegen ID: 383; NCBI Protein GI: 562026; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011037
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model.  These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge [PubMed: 12117973]." ;
    rdfs:label "PtxB" ;
    rdfs:seeAlso "Protegen ID: 384; NCBI Protein GI: 225311180; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011038
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model.  These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge [PubMed: 12117973]." ;
    rdfs:label "PtxC" ;
    rdfs:seeAlso "Protegen ID: 385; NCBI Protein GI: 225311183; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011039
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model. These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge [PubMed: 12117973]." ;
    rdfs:label "PtxE" ;
    rdfs:seeAlso "Protegen ID: 386; NCBI Protein GI: 225311182; NCBITaxon: 520" ;
    rdfs:subClassOf obo:VO_0010847, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011040
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protection against a BHV-1 challenge was obtained in calves immunized with the plasmid encoding tgD-VP22 (UL49), as shown by significant reductions in viral excretion [PubMed: 15650221]." ;
    rdfs:label "UL49" ;
    rdfs:seeAlso "Protegen ID: 389; NCBI Gene GI: 1487397; NCBI Protein GI: 9629826; NCBI Protein Accession: NP_045310; NCBITaxon: 10320" ;
    rdfs:subClassOf obo:VO_0010802, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011041
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Calves were injected intranasally with either AdCMVgC or AdCMVgD (US6) or a combination of these two recombinants or a commercially available live vaccine for comparison. The highest BHV-1 neutralizing antibody titres were obtained with AdCMVgD (US6) followed by the live vaccine and to a lower extent with the combination of the two recombinants. Calves were protected against intranasal BHV-1 challenge performed 3 weeks after the second immunization [PubMed: 11818166]." ;
    rdfs:label "US6" ;
    rdfs:seeAlso "Protegen ID: 390; NCBI Gene GI: 1487406; NCBI Protein GI: 9629886; NCBI Protein Accession: NP_045370; NCBITaxon: 10320" ;
    rdfs:subClassOf obo:VO_0010802, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011042
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization of calves with truncated gpI (US7) protein induced gpI-specific nasal IgA, IgG1, serum neutralizing antibodies and gpI-specific peripheral lymphocyte proliferation. All immunized calves were protected from clinical disease after BHV-1 challenge. Further, nine of ten immunized calves had no intranasal viral shedding [PubMed: 8147097]." ;
    rdfs:label "US7" ;
    rdfs:seeAlso "Protegen ID: 392; NCBI Gene GI: 4783432; NCBI Protein GI: 9629887; NCBI Protein Accession: NP_045371; NCBITaxon: 10320" ;
    rdfs:subClassOf obo:VO_0010802, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011043
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A DNA vaccine expressing glycoprotein C (gC, UL44) of bovine herpesvirus-1 (BHV-1) was evaluated for inducing immunity in bovines.  Results indicate that DNA immunization with gC could induce neutralizing antibody and lymphoproliferative responses with BHV-1 responsive memory B cells in bovines. However, the immunity developed sufficient for only partial protection against BHV-1 challenge [PubMed: 11182496]." ;
    rdfs:label "UL44" ;
    rdfs:seeAlso "Protegen ID: 393; NCBI Gene GI: 4783424; NCBI Protein GI: 9629830; NCBI Protein Accession: NP_045314; NCBITaxon: 10320" ;
    rdfs:subClassOf obo:VO_0010802, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011044
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Chitosan-DNA vaccines were prepared by embedding pcDNA3.1(+)-cadF and pcDNA3.1(+)-peblA with chitosan respectively.  The mice immunized with chitosan-DNA vaccines have generated high levels of IgA and IgG from the sera and IgA from the intestinal secretions and the P/N value went up to 20.58, 30.13 and 6.87 respectively.  The chitosan-DNA vaccines induced strongest level of protection in BALB/c mice against challenge with C. jejuni HS:19 strain and the protective efficacies was 93.70 [PubMed: 18206008]." ;
    rdfs:label "CadF" ;
    rdfs:seeAlso "Protegen ID: 396; NCBI Protein GI: 4704601; NCBITaxon: 197" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011045
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Chitosan-DNA vaccines were prepared by embedding pcDNA3.1(+)-cadF and pcDNA3.1(+)-peblA with chitosan respectively. The mice immunized with chitosan-DNA vaccines have generated high levels of IgA and IgG from the sera and IgA from the intestinal secretions and the P/N value went up to 20.58, 30.13 and 6.87 respectively. The chitosan-DNA vaccines induced strongest level of protection in BALB/c mice against challenge with C. jejuni HS:19 strain and the protective efficacies was 93.70 [PubMed: 18206008]." ;
    rdfs:label "Peb1A" ;
    rdfs:seeAlso "Protegen ID: 397; NCBI Protein GI: 112360246; NCBITaxon: 192222" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011046
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were immunized intranasally with two doses of 3 to 50 microgram of MBP-FlaA.  The protective efficacies of a 50 microgram of MBP-FlaA plus LT(R192G) dose against disease symptoms and intestinal colonization were 81.1 and 84%, respectively. When mice which had been immunized with 50 microgram of MBP-FlaA plus LT(R192G) intranasally were challenged orally with 8 x 10(10), 8 x 10(9), or 8 x 10(8) cells of strain 81-176, the protective efficacies against intestinal colonization at 7 days postinfection were 71.4, 71.4, and 100%, respectively [PubMed: 10531231]." ;
    rdfs:label "FlaA from C. jejuni 81-176" ;
    rdfs:seeAlso "Protegen ID: 398; NCBI Gene GI: 4682159; NCBI Protein GI: 121612545; NCBI Protein Accession: YP_001000997; NCBITaxon: 354242" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011047
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunogenicity and protective efficacy of three Campylobacter jejuni flagellum-secreted proteins, FlaC, FspA1, and FspA2, were compared by use of a mouse model.  Immunization with FspA1 resulted in 57.8% protection without adjuvant or 63.8% protection with adjuvant against homologous challenge with 81-176 [PubMed: 18426878]." ;
    rdfs:label "FspA1" ;
    rdfs:seeAlso "Protegen ID: 399; NCBI Protein GI: 116292649; NCBITaxon: 197" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011048
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunogenicity and protective efficacy of three Campylobacter jejuni flagellum-secreted proteins, FlaC, FspA1, and FspA2, were compared by use of a mouse model.  All three proteins were immunogenic, FlaC provided an 18% protection against disease from C. jejuni 81-176 [PubMed: 18426878]." ;
    rdfs:label "FlaC" ;
    rdfs:seeAlso "Protegen ID: 400; NCBI Gene GI: 4682885; NCBI Protein GI: 121612344; NCBI Protein Accession: YP_001000416; NCBITaxon: 354242" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011049
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunogenicity and protective efficacy of three Campylobacter jejuni flagellum-secreted proteins, FlaC, FspA1, and FspA2, were compared by use of a mouse model.  Immunization with FspA2 provided 38.4% (without adjuvant) or 47.2% (with adjuvant) protection against disease from homologous challenge with CG8486 [PubMed: 18426878]." ;
    rdfs:label "FspA2" ;
    rdfs:seeAlso "Protegen ID: 409; NCBI Protein GI: 116292677; NCBITaxon: 197" ;
    rdfs:subClassOf obo:VO_0010765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011050
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A DNA vaccination trial was performed on sheep to determine whether vaccination with bovine leukemia virus (BLV) transactivator Tax DNA is effective against BLV infection.  Results showed higher levels of virus titers in control sheep than those in Tax-vaccinated sheep. Higher levels of IFN-gamma mRNA expression have been demonstrated in vaccinated sheep after the challenge. These results suggested that Th1 type immune response induced by Tax DNA vaccine inhibited BLV propagation in vaccinated sheep at the early phase of infection [PubMed: 14665749]." ;
    rdfs:label "Tax" ;
    rdfs:seeAlso "Protegen ID: 410; NCBI Gene GI: 2760848; NCBI Protein GI: 9626228; NCBI Protein Accession: NP_056895; NCBITaxon: 11901" ;
    rdfs:subClassOf obo:VO_0010797, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011051
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 (encoded by env gene) and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge [PubMed: 10824867]." ;
    rdfs:label "Env/Rex/Tax" ;
    rdfs:seeAlso "Protegen ID: 411; NCBI Gene GI: 2760849; NCBI Protein GI: 9626230; NCBI Protein Accession: NP_056898; NCBITaxon: 11901" ;
    rdfs:subClassOf obo:VO_0010797, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011052
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Young mink kits (n=8) were vaccinated with DNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV).  The mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN-gamma producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV [PubMed: 19596418]." ;
    rdfs:label "CDVgp6 haemagglutinin protein H" ;
    rdfs:seeAlso "Protegen ID: 412; NCBI Gene GI: 1489792; NCBI Protein GI: 9630651; NCBI Protein Accession: NP_047206; NCBITaxon: 11232" ;
    rdfs:subClassOf obo:VO_0010809, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011053
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study reports the engineering and the characterization of two replication-competent canine adenovirus type 2 (CAV2)-based vaccines expressing, respectively, the CDV hemagglutinin (HA) and fusion (F) antigens (CDVgp5). We first demonstrated that the intranasal vaccination with a mixture of both recombinant CAV2s provides an excellent level of protection in seronegative puppies, confirming the value of replication-competent adenovirus-based vectors for mucosal vaccination [PubMed: 12297394]." ;
    rdfs:label "CDVgp5" ;
    rdfs:seeAlso "Protegen ID: 413; NCBI Gene GI: 1489793; NCBI Protein GI: 9630650; NCBI Protein Accession: NP_047205; NCBITaxon: 11232" ;
    rdfs:subClassOf obo:VO_0010809, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011054
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs).  Results show that the inactivated CVP is able to protect dogs from a lethal challenge with CPV following parenteral immunization with the vaccine.  Dogs immunized with the inactivated CPMV-PARVO1 in adjuvant displayed no clinical signs of disease and shedding of CPV in faeces was limited following CPV challenge. [PubMed: 11395200]." ;
    rdfs:label "VP2" ;
    rdfs:seeAlso "Protegen ID: 414; NCBI Gene GI: 1489588; NCBITaxon: 10788" ;
    rdfs:subClassOf obo:VO_0010807, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011055
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "This study shows that a plasmid DNA (pGT36VP1) encoding the full length VP1 region of canine parvovirus (CPV) induces immunity that protects dogs against challenge with virulent virus [PubMed: 9569471]." ;
    rdfs:label "VP1" ;
    rdfs:seeAlso "Protegen ID: 415; NCBI Gene GI: 1489587; NCBITaxon: 10788" ;
    rdfs:subClassOf obo:VO_0010807, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011056
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system.  DNA pol III Gamma and Tau (CP #1, dnaX) was found to be protective.  CP #1 (dnaX) was more protective than the live-vaccine, positive control.  [PubMed: 15811648]." ;
    rdfs:label "DnaX" ;
    rdfs:seeAlso "Protegen ID: 416; NCBI Protein GI: 62148024; NCBITaxon: 218497" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011057
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system. Glu-tRNA Gln Amidotransferase (CP #2, gatC) was found to be protective. Three of the clones (CP #1) elicited protection that was statistically higher than the unvaccinated control, which has high variance [PubMed: 15811648]." ;
    rdfs:label "GatC" ;
    rdfs:seeAlso "Protegen ID: 417; NCBI Protein GI: 62184917; NCBITaxon: 218497" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011058
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system.   Protective clone CP #4 (OMP90A, pomp90A) was diluted 1/2000 in a non-protective sublibrary pool of clones. This CP #4-spiked sublibrary conferred protection.  Five clones were significantly more protective than the genes encoding fewer than 50 amino acids (CP #1 and 7, p-value of less than 0.05 when comparing lung weights). [PubMed: 15811648]." ;
    rdfs:label "Pomp90A" ;
    rdfs:seeAlso "Protegen ID: 418; NCBI Protein GI: 187438939; NCBITaxon: 83555" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011059
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system.  CP #5 (Transglycolase/transpeptidase, CAB049 putative penicillin-binding protein) was significantly more protective than the genes encoding fewer than 50 amino acids (p-value of less than 0.05 when comparing lung weights).  The chlamydial loads generally tracked with protection and the most protective genes were significantly lower than in unvaccinated controls (p < 0.05 in the Mannhitney U-test for genes CP #1, 2, 4, 9, 10) [PubMed: 15811648]." ;
    rdfs:label "CAB049 putative penicillin-binding protein" ;
    rdfs:seeAlso "Protegen ID: 419; NCBI Protein GI: 62184696; NCBITaxon: 218497" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011060
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system.  CP #7 (omlA) was significantly more protective than the genes encoding fewer than 50 amino acids (p-value of less than 0.05 when comparing lung weights). The chlamydial loads generally tracked with protection and the most protective genes were significantly lower than in unvaccinated controls (p < 0.05 in the Mannhitney U-test for genes CP #1, 2, 4, 9, 10) [PubMed: 15811648]." ;
    rdfs:label "OmlA" ;
    rdfs:seeAlso "Protegen ID: 420; NCBI Protein GI: 62184824; NCBITaxon: 218497" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011061
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system.  Of the 14 individually tested clones, CP #1 through CP #9 had positive relative protection scores.  CP #8 (CAB613, Oligopeptidase) was found to confer protection [PubMed: 15811648]." ;
    rdfs:label "CAB613 putative peptidase" ;
    rdfs:seeAlso "Protegen ID: 421; NCBI Protein GI: 62185225; NCBITaxon: 218497" ;
    rdfs:subClassOf obo:VO_0010817, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011062
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Animals vaccinated with Gam82 and challenged with E. maxima showed lower oocyst shedding and reduced intestinal pathology compared with non-vaccinated and parasite-challenged animals. Gam82 vaccination also stimulated the production of antigen-specific serum antibodies and induced greater levels of IL-2 and IL-15 mRNAs compared with non-vaccinated controls. These results demonstrate that the Gam82 recombinant protein protects against E. maxima and augments humoral and cell-mediated immunity [PubMed: 20178868]." ;
    rdfs:label "Gam82" ;
    rdfs:seeAlso "Protegen ID: 457; NCBI Protein GI: 38565038; NCBITaxon: 5804" ;
    rdfs:subClassOf obo:VO_0010833, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011063
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Birds vaccinated with Eimeria tenella microneme recombinant gene (EtMIC2) and encoded protein developed protective immunity against infection by E. tenella as assessed by significantly increased body weight gain and decreased fecal oocyst shedding compared with non-vaccinated controls. Vaccination with the EtMIC2 gene also led to protective immunity against infection by E. acervulina, but not E. maxima [PubMed: 15882535]." ;
    rdfs:label "MIC2" ;
    rdfs:seeAlso "Protegen ID: 459; NCBI Protein GI: 225579627; NCBITaxon: 5802" ;
    rdfs:subClassOf obo:VO_0010823, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011064
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Two recombinant Mycobacterium bovis BCG (rBCG) strains carrying the Eimeria tenella rhomboid gene (Rho) delivered by extrachromosomal vector pMV261 and integrative vector pMV361 were evaluated for their ability to protect chickens against E. tenella challenge. Chickens were immunized intranasal with BCG, rBCG pMV261-Rho, or rBCG pMV361-Rho twice at a 2-week interval. All the recombinant BCG immunized chickens developed specific immune responses, and there was a significant increases of the percentages of CD4(+) and CD8(+) cells compared to the control (P<0.05). Challenge experiments demonstrated that the two rBCG strains could provide significant protection against E. tenella challenge [PubMed: 19117681]." ;
    rdfs:label "Rho" ;
    rdfs:seeAlso "Protegen ID: 460; NCBI Protein GI: 84043169; NCBITaxon: 5802" ;
    rdfs:subClassOf obo:VO_0010823, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011065
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The immunization procedure of DNA vaccine pcDNA-TA4-IL-2 of Eimeria tenella, including route, dose, time of immunization and age of primary immunization of chicken, was optimized.  results illustrated that 25 microg was the optimal dose and intramuscular injection was the most effective route to induce protective immunity in Chinese Yellow chickens [PubMed: 19019543]." ;
    rdfs:label "TA4" ;
    rdfs:seeAlso "Protegen ID: 461; NCBI Protein GI: 84783094; NCBITaxon: 5802" ;
    rdfs:subClassOf obo:VO_0010823, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011066
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The Eimeria tenella antigen gene (3-1E) and chicken interferon gamma gene (ChIFN-gamma) were subcloned into the mammalian expression vector proVAX forming the plasmids proE and prol.  After challenge the proIE-vaccinated chickens showed protective immunity as demonstrated by significantly reduced oocyst shedding [PubMed: 17274297]." ;
    rdfs:label "3-1E" ;
    rdfs:seeAlso "Protegen ID: 463; NCBI Protein GI: 126362934; NCBITaxon: 5802" ;
    rdfs:subClassOf obo:VO_0010823, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011067
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A cDNA clone derived from sporulated oocysts of Eimeria tenella and encoding the expression product GX3262 was identified using a monoclonal antibody raised against Eimeria acervulina sporozoites.  After challenge with an experimental E. tenella infection, the greatest degree of protection in immunized broiler chickens was seen after only a single immunization of 2-day-old birds with a live recombinant E. coli preparation [PubMed: 2659532]." ;
    rdfs:label "GX3262" ;
    rdfs:seeAlso "Protegen ID: 464; NCBI Protein GI: 102304; NCBITaxon: 5802" ;
    rdfs:subClassOf obo:VO_0010823, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011068
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study describes experiments which demonstrate that the vaccine, (EURIFEL FeLV; Merial) that expresses the FeLV env and gag protective genes, is effective against any oronasal FeLV challenge. The protection was shown to be solid against an oronasal challenge one year after the initial vaccination, and was effective against a very severe 'in-contact' challenge [PubMed: 12934796]." ;
    rdfs:label "Env" ;
    rdfs:seeAlso "Protegen ID: 465; NCBI Gene GI: 1491868; NCBI Protein GI: 9630709; NCBI Protein Accession: NP_047256; NCBITaxon: 11768" ;
    rdfs:subClassOf obo:VO_0010806, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011069
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The vaccine, (EURIFEL FeLV; Merial) that expresses the FeLV env and gag protective genes, is effective against any oronasal FeLV challenge. The protection was shown to be solid against an oronasal challenge one year after the initial vaccination, and was effective against a very severe 'in-contact' challenge [PubMed: 12934796]." ;
    rdfs:label "Gag" ;
    rdfs:seeAlso "Protegen ID: 466; NCBI Protein GI: 323916; NCBITaxon: 11768" ;
    rdfs:subClassOf obo:VO_0010806, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011070
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intranasal immunization of HLA-DR4 tg mice with the single antigen FopB from F. tularensis subsp. novicida conferred significant protection against lethal pulmonary challenge with an F. tularensis subsp. holarctica live vaccine strain." ;
    rdfs:label "FopB" ;
    rdfs:seeAlso "Protegen ID: 468; NCBI Gene GI: 4547777; NCBI Protein GI: 118496734; NCBI Protein Accession: YP_897784; NCBITaxon: 401614" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011071
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intranasal vaccination with KKF235 (F. tularensis subsp. novicida mutant (DeltaiglB) ) protected mice from subsequent homotypic challenge with U112 as well as heterotypic challenge with F. tularensis subsp. holarctica (LVS).  Most significantly, oral immunization with KKF235 protected mice from a highly lethal subsp. tularensis (SCHU S4) pulmonary challenge [PubMed: 20016043]." ;
    rdfs:label "IglB" ;
    rdfs:seeAlso "Protegen ID: 469; NCBI Gene GI: 4548125; NCBI Protein GI: 118497903; NCBI Protein Accession: YP_898953; NCBITaxon: 401614" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011072
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with rLm/iglC were protected against lethal challenge with F. tularensis LVS administered by the intranasal route, a route chosen to mimic airborne infection, and, most importantly, against aerosol challenge with the highly virulent Type A F. tularensis SchuS4 strain [PubMed: 19126421]." ;
    rdfs:label "IglC1" ;
    rdfs:seeAlso "Protegen ID: 470; NCBI Gene GI: 3191591; NCBI Protein GI: 56708413; NCBI Protein Accession: YP_170309; NCBITaxon: 177416" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011073
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with rLm/iglC were protected against lethal challenge with F. tularensis LVS administered by the intranasal route, a route chosen to mimic airborne infection, and, most importantly, against aerosol challenge with the highly virulent Type A F. tularensis SchuS4 strain [PubMed: 19126421]." ;
    rdfs:label "IglC2" ;
    rdfs:seeAlso "Protegen ID: 471; NCBI Gene GI: 3191814; NCBI Protein GI: 56708721; NCBI Protein Accession: YP_170617; NCBITaxon: 177416" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011074
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with WbtI(G191V) protected mice against a relatively low-dose intraperitoneal challenge with LVS (F. tularensis subspecies holarctica live vaccine strain), but was less protective against a high-dose challenge [PubMed: 17768257]." ;
    rdfs:label "WbtI" ;
    rdfs:seeAlso "Protegen ID: 472; NCBI Gene GI: 5522688; NCBI Protein GI: 156502002; NCBI Protein Accession: YP_001428067; NCBITaxon: 458234" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011075
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers have shown that mice that had been immunized with purified heat shock protein 60 (Hsp60, groEL) isolated from Francisella tularensis were protected against a subsequent challenge with some strains of the bacterium [PubMed: 15213156]." ;
    rdfs:label "GroEL" ;
    rdfs:seeAlso "Protegen ID: 473; NCBI Protein GI: 282159959; NCBITaxon: 510831" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011076
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A 17-kDa lipoprotein, TUL4, of the facultative intracellular bacterium Francisella tularensis is one of several membrane proteins that induce an in vitro response in T cells from F. tularensis-primed humans.  When mice were immunized with S. typhimurium chi 4072(pTUL4-15), some animals showed an antibody response and a T-cell response to TUL4.  The present study demonstrated that the 17-kDa lipoprotein TUL4 of F. tularensis is involved in a protective immunity to tularemia [PubMed: 1612751]." ;
    rdfs:label "TUL4" ;
    rdfs:seeAlso "Protegen ID: 474; NCBI Protein GI: 148688; NCBITaxon: 263" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011077
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice were vaccinated intranasally (i.n.) with the sodB(Ft) mutant and challenged i.n. with lethal doses of F. tularensis SchuS4. SodB(Ft) vaccinated mice following SchuS4 challenge exhibited significantly reduced bacterial burden in lungs, liver and spleen, regulated production of pro-inflammatory cytokines and less severe histopathological lesions compared to the LVS vaccinated mice. The sodB(Ft) vaccination induced a potent humoral immune response and protection against SchuS4 required both CD4 and CD8 T cells in the vaccinated mice [PubMed: 18692537]." ;
    rdfs:label "SodB from F. tularensis SCHU S4" ;
    rdfs:seeAlso "Protegen ID: 475; NCBI Gene GI: 3190713; NCBI Protein GI: 56707247; NCBI Protein Accession: YP_169143; NCBITaxon: 177416" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011078
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Anti-FopA MAbs protected 90% of nave C3H/HeN mice from lethal challenge with F. tularensis LVS when administered prophylactically as well as therapeutically [PubMed: 19176692]." ;
    rdfs:label "FopA" ;
    rdfs:seeAlso "Protegen ID: 476; NCBI Gene GI: 4306351; NCBI Protein GI: 115315051; NCBI Protein Accession: YP_763774; NCBITaxon: 393011" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011079
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Anti-lpnA MAbs conferred significant, although not complete, protection of nave C3H/HeN mice from lethal challenge with F. tularensis LVS when administered therapeutically [PubMed: 19176692]." ;
    rdfs:label "LpnA" ;
    rdfs:seeAlso "Protegen ID: 477; NCBI Gene GI: 3191792; NCBI Protein GI: 56708002; NCBI Protein Accession: YP_169898; NCBITaxon: 177416" ;
    rdfs:subClassOf obo:VO_0010760, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011080
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The gene encoding the full length cyst wall protein-2 (CWP2) from Giardia lamblia was subcloned into the pCDNA3 mammalian expression vector and stably introduced into S. typhimurium STM1.  Challenge infection with live Giardia muris cysts revealed that mice receiving the CWP2-encoding DNA vaccine were able to reduce cyst shedding by approximately 60% compared to control mice [PubMed: 17996337]." ;
    rdfs:label "CWP2" ;
    rdfs:seeAlso "Protegen ID: 479; NCBI Gene GI: 5703171; NCBI Protein GI: 159120052; NCBI Protein Accession: XP_001710242; NCBITaxon: 50803" ;
    rdfs:subClassOf obo:VO_0010829, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011081
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Rats vaccinated with PD (hpd) cleared NT H. influenzae better after middle ear and pulmonary bacterial challenge, and chinchillas vaccinated with PD showed significant protection against NT H. influenzae-dependent acute otitis media. In a clinical trial involving children, PD was used as an antigenically active carrier protein in an 11-valent pneumococcal conjugate investigational vaccine; significant protection was achieved against acute otitis media not only caused by pneumococci but also caused by NT H. influenzae [PubMed: 18230042]." ;
    rdfs:label "Hpd" ;
    rdfs:seeAlso "Protegen ID: 480; NCBI Protein GI: 148971; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011082
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In a chinchilla model of otitis media, initial screening of P5-fimbrin, delivered singly or in combination with either Freund's adjuvant or alum, indicated that augmented bacterial clearance from the nasopharynx, the middle ears, or both anatomical sites could be induced by parenteral immunization with P5-fimbrin combined with lipoprotein D, lipoprotein D alone, or the synthetic chimeric peptide LB1 (derived from P5-fimbrin), respectively [PubMed: 10338477]." ;
    rdfs:label "OmpP5" ;
    rdfs:seeAlso "Protegen ID: 482; NCBI Gene GI: 3430592; NCBI Protein GI: 68249712; NCBI Protein Accession: YP_248824; NCBITaxon: 281310" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011083
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Purified rD15 was found to be highly immunogenic in mice, guinea pigs, and rabbits, and passive transfer of anti-rD15 antibodies protected infant rats from challenge with H. influenzae type b or type a in infant rat models of bacteremia [PubMed: 9284140]." ;
    rdfs:label "D15" ;
    rdfs:seeAlso "Protegen ID: 483; NCBI Gene GI: 3430379; NCBI Protein GI: 68249503; NCBI Protein Accession: YP_248615; NCBITaxon: 281310" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011084
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Rabbit antibody prepared against P2 from one strain was cross-reactive with P2 isolated from the other two heterologous strains by Western blot. This antibody passively protected infant rats against type b Haemophilus infection caused by the homologous organism, but not against challenge by a strain with the heterologous 36,500 mol wt P2 protein [PubMed: 6603479]." ;
    rdfs:label "OmpP2" ;
    rdfs:seeAlso "Protegen ID: 485; NCBI Gene GI: 3429565; NCBI Protein GI: 68248747; NCBI Protein Accession: YP_247859; NCBITaxon: 281310" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011085
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Seoul virus (SEOV) is one of the four known hantaviruses causing hemorrhagic fever with renal syndrome (HFRS).  A replication-competent recombinant canine adenovirus type 2 expressing the Gc protein of SEOV (rCAV-2-Gc) in BALB/c mice induced complete protection against a intensive infectious challenge with ~1,000 50% infective doses (ID50) for SEOV strain CC-2 [PubMed: 20181748]." ;
    rdfs:label "Gc" ;
    rdfs:seeAlso "Protegen ID: 486; NCBI Protein GI: 284157806; NCBITaxon: 11608" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011086
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study used a deer mouse infection model to test the protective efficacy of genetic vaccine candidates for Sin Nombre (SN) virus that were known to provoke immunological responses in BALB/c mice.  Protective epitopes were localized in each of four overlapping cDNA fragments that encoded portions of the SN virus G1 glycoprotein antigen; the nucleocapsid gene also was protective [PubMed: 12075094]." ;
    rdfs:label "G1" ;
    rdfs:seeAlso "Protegen ID: 487; NCBI Protein GI: 1113859; NCBITaxon: 37705" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011087
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study used a deer mouse infection model to test the protective efficacy of genetic vaccine candidates for Sin Nombre (SN) virus that were known to provoke immunological responses in BALB/c mice. Protective epitopes were localized in each of four overlapping cDNA fragments that encoded portions of the SN virus G1 glycoprotein antigen; the nucleocapsid gene (SNVsSgp1) also was protective [PubMed: 12075094]." ;
    rdfs:label "SNVsSgp1" ;
    rdfs:seeAlso "Protegen ID: 489; NCBI Gene GI: 2943142; NCBI Protein GI: 38371726; NCBI Protein Accession: NP_941975; NCBITaxon: 37705" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011088
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To investigate the ability of recombinant N (rN, nucleocapsid proteins) from different hantaviruses to elicit cross-protection, we immunized bank voles with rN from Puumala (PUUV), Topografov (TOPV), Andes (ANDV), and Dobrava (DOBV) viruses and subsequently challenged them with PUUV. All animals immunized with PUUV (PUUVsSgp1) and TOPV rN were completely protected [PubMed: 12050380]." ;
    rdfs:label "PUUVsSgp1" ;
    rdfs:seeAlso "Protegen ID: 490; NCBI Gene GI: 2943083; NCBI Protein GI: 38371721; NCBI Protein Accession: NP_941984; NCBITaxon: 11604" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011089
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To investigate the ability of recombinant N (rN, nucleocapsid proteins) from different hantaviruses to elicit cross-protection, we immunized bank voles with rN from Puumala (PUUV), Topografov (TOPV), Andes (ANDV), and Dobrava (DOBV) viruses and subsequently challenged them with PUUV. All animals immunized with PUUV and TOPV rN were completely protected [PubMed: 12050380]." ;
    rdfs:label "N protein [Topografov virus]" ;
    rdfs:seeAlso "Protegen ID: 491; NCBI Protein GI: 4757106; NCBITaxon: 83192" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011090
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers vaccinated hamsters with a vaccinia virus-vectored vaccine expressing the M and the S segments of Hantaan (HTN) virus and challenged them with HTN, Seoul (SEO), or Puumala (PUU) virus.  Study found that vaccinated hamsters, challenged with HTN or SEO virus, were neither viremic nor had evidence of virus in their lungs or kidneys [PubMed: 7666542]." ;
    rdfs:label "M Segment" ;
    rdfs:seeAlso "Protegen ID: 492; NCBI Protein GI: 1389703; NCBITaxon: 11599" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011091
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Passive transfer of spleen cells from mice immunized with rNP (HTNVsSgp1) conferred partial protection or prolongation of time to death from fatal Hantaan virus infection in suckling mice which were challenged with Hantaan virus at 40 LD50 (survival rate: 43%) or 4 LD50 (survival rate: 43%) [PubMed: 8517793]." ;
    rdfs:label "HTNVsSgp1" ;
    rdfs:seeAlso "Protegen ID: 493; NCBI Gene GI: 2943078; NCBI Protein GI: 38371711; NCBI Protein Accession: NP_941977; NCBITaxon: 11599" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011092
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Nonreplicating adenovirus (Ad) vectors that express Andes hantavirus (ANDV) nucleocapsid protein (AdN, ANDVsSgp1) or glycoproteins (AdG(N) and AdG(C)) were constructed . When administered once, all three Ad vectors, individually or in combination, elicited a robust immune response that protected Syrian hamsters from a lethal ANDV infection that mimics the pulmonary disease seen in humans. No vaccinated animal died, and there were no obvious clinical signs of disease [PubMed: 19403663]." ;
    rdfs:label "ANDVsSgp1" ;
    rdfs:seeAlso "Protegen ID: 494; NCBI Gene GI: 991232; NCBI Protein GI: 19744950; NCBI Protein Accession: NP_604471; NCBITaxon: 46607" ;
    rdfs:subClassOf obo:VO_0010768, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011093
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study compared a current HBV vaccine that contains recombinant hepatitis B surface antigen HBsAg) adsorbed to alum in chimpanzees, with two novel vaccine strategies that have proven superior to the current vaccine in mice. All animals receiving either control or CpG-containing subunit vaccines at 0 and 4 weeks attained titers of HBsAg-specific antibody (anti-HBs) considered protective (> or =10 mIU/ml) and were indeed protected from challenge at 8 weeks with 10(3.5) 50% chimp infectious doses (CID(50)) of intravenous HBV [PubMed: 16428890]." ;
    rdfs:label "Hepatitis B surface antigen" ;
    rdfs:seeAlso "Protegen ID: 495; NCBI Protein GI: 128168861; NCBITaxon: 10407" ;
    rdfs:subClassOf obo:VO_0010781, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011094
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The immunological protection of pVAX-PS, a DNA vaccine, was assessed in the tree shrews model. pVAX-PS was constructed by inserting the gene encoding the middle (pre-S2 plus S) envelope protein of HBV into a plasmid vector pVAX1.  Results indicated that pVAX-PS immunization could induce remarkable humoral immune response and prevent the experimental tree shrews from infection of HBV [PubMed: 12932306]." ;
    rdfs:label "PreS2 middle surface protein" ;
    rdfs:seeAlso "Protegen ID: 496; NCBI Protein GI: 113207330; NCBITaxon: 10407" ;
    rdfs:subClassOf obo:VO_0010781, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011095
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunisation with a plasmid encoding the DHBV large (L) envelope protein (HBVgp2 pre-S1/pre-S2/S) induced a strong, specific, highly neutralising and long-lasting anti-preS humoral response in uninfected ducks. Importantly, maternal antibodies elicited by such DNA immunisation were vertically transmitted and protected progeny against viral challenge [PubMed: 12531335]." ;
    rdfs:label "HBVgp2 pre-S1/pre-S2/S" ;
    rdfs:seeAlso "Protegen ID: 497; NCBI Gene GI: 944569; NCBI Protein GI: 77680739; NCBI Protein Accession: YP_355333; NCBITaxon: 10407" ;
    rdfs:subClassOf obo:VO_0010781, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011096
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) gene was inserted into an intergenic site in the unique short region of the Oka VZV genome. Expression of gD2 in cells infected with the recombinant Oka strain VZV (ROka-gD2) was confirmed by antibody staining of fixed cells and by immunoblot analysis.  Forty days after the third inoculation, guinea pigs were challenged intravaginally with HSV-2. Inoculation of guinea pigs with ROka-gD2 significantly reduced the severity of primary HSV-2 infection (P < 0.001) [PubMed: 7494331]." ;
    rdfs:label "US6" ;
    rdfs:seeAlso "Protegen ID: 499; NCBI Gene GI: 1487358; NCBI Protein GI: 9629336; NCBI Protein Accession: NP_044536; NCBITaxon: 10310" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011097
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The present study evaluated the modulatory functions of salbutamol co-administered with DNA vaccine expressing gB (UL27) of herpes simplex virus (HSV) via intranasal (i.n.) route.  The enhanced immune responses caused by co-administration of salbutamol provided effective and rapid responses to HSV mucosal challenge, thereby conferring prolonged survival and reduced inflammation against viral infection [PubMed: 19641376]." ;
    rdfs:label "UL27 from Herpes simplex virus type 2" ;
    rdfs:seeAlso "Protegen ID: 500; NCBI Protein GI: 1869850; NCBITaxon: 10310" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011098
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice receiving a glycoprotein D1 (gD1, US5) DNA vaccine alone were 80% protected against a subsequent HSV-1 challenge.  Results also indicate that the administration of NLX as an adjuvant improved protective immunity against HSV-1 [PubMed: 19174474]." ;
    rdfs:label "US5" ;
    rdfs:seeAlso "Protegen ID: 501; NCBI Gene GI: 2703406; NCBI Protein GI: 9629447; NCBI Protein Accession: NP_044668; NCBITaxon: 10298" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011099
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study demonstrated that recombinant Listeria monocytogenes (Lm) expressing the H-2K(b) glycoprotein B (gB, UL27)(498-505) peptide from HSV-1 triggers a robust CD8 T cell response to this Ag resulting in protective immunity to HSV infection in mice [PubMed: 17404252]." ;
    rdfs:label "UL27 from Herpes simplex virus type 1" ;
    rdfs:seeAlso "Protegen ID: 502; NCBI Gene GI: 2703455; NCBI Protein GI: 9629408; NCBI Protein Accession: NP_044629; NCBITaxon: 10298" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011100
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Particle-mediated DNA vaccination of mice with a DNA plasmid-encoding ICP27 resulted in the induction of ICP27-specific IFN-gamma and TNF-alpha production in Balb/c mice.  When the DNA vaccine was supplemented with as little as 50ng of a vector encoding the A and B subunits of the Escherichia coli heat labile enterotoxin (LT), animals were profoundly protected from morbidity and mortality [PubMed: 16621198]." ;
    rdfs:label "ICP27 from Herpes simplex virus type 2" ;
    rdfs:seeAlso "Protegen ID: 503; NCBI Protein GI: 124181; NCBITaxon: 10315" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011101
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Epitopes from the ICP27 (H1, H2), glycoprotein B (gB) and glycoprotein D (gD) proteins of HSV-1 were attached to either the J TCBL/ICBL or the G TCBL/ICBL. The JH1, JH2, JgB and JgD vaccines elicited DTH responses without antibody but conferred protection upon lethal challenge with HSV [PubMed: 15569635]." ;
    rdfs:label "ICP27 from Herpes simplex virus type 1" ;
    rdfs:seeAlso "Protegen ID: 504; NCBI Protein GI: 75812153; NCBITaxon: 10298" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011102
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In two experiments, mice immunised with phage displaying a single epitope of gG2 (US4) were protected against challenge with a lethal dose of whole HSV-2 [PubMed: 10725197]." ;
    rdfs:label "US4" ;
    rdfs:seeAlso "Protegen ID: 505; NCBI Gene GI: 1487356; NCBI Protein GI: 9629334; NCBI Protein Accession: NP_044534; NCBITaxon: 10310" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011103
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protection against a lethal intraperitoneal challenge of HSV-1 (5 x 10(4) pfu) with gC (UL44) or gE plasmid vaccination could be demonstrated if the inoculating dose of DNA was 250 microg.  All mice immunized with vaccinia recombinants expressing either gC or gE survived HSV-1 challenge [PubMed: 9728527]." ;
    rdfs:label "UL44" ;
    rdfs:seeAlso "Protegen ID: 506; NCBI Gene GI: 2703410; NCBI Protein GI: 9629425; NCBI Protein Accession: NP_044646; NCBITaxon: 10298" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011104
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protection against a lethal intraperitoneal challenge of HSV-1 (5 x 10(4) pfu) with gC or gE (US8) plasmid vaccination could be demonstrated if the inoculating dose of DNA was 250 microg. All mice immunized with vaccinia recombinants expressing either gC or gE survived HSV-1 challenge [PubMed: 9728527]." ;
    rdfs:label "US8" ;
    rdfs:seeAlso "Protegen ID: 507; NCBI Gene GI: 2703448; NCBI Protein GI: 9629449; NCBI Protein Accession: NP_044670; NCBITaxon: 10298" ;
    rdfs:subClassOf obo:VO_0010834, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011105
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "E7" ;
    a owl:Class ;
    rdfs:comment "Researchers combined the HPV16 E7 peptide(38-61) with a murine IgG heavy chain constant region to construct a chimeric protein compound.  The chimeric vaccine candidate was able to effectively protect mice against the challenge of HPV16-positive tumor cells, and to eradicate HPV16-expressing tumors in mice [PubMed: 15661238]." ;
    rdfs:label "HPV E7" ;
    rdfs:seeAlso "Protegen ID: 509; NCBI Gene GI: 1489079; NCBI Protein GI: 9627105; NCBI Protein Accession: NP_041326; NCBITaxon: 333760" ;
    rdfs:subClassOf obo:VO_0010786, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011106
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "L2" ;
    a owl:Class ;
    rdfs:comment "Antibody responses of mice (n = 120) and rabbits (n = 23) to vaccination with HPV-16 amino-terminal L2 polypeptides or multitype L2 fusion proteins were compared.  11-200 x 3 formulated in GPI-0100 adjuvant or alum with 1018 ISS protected mice against HPV-16 challenge (reduction in HPV-16 infection vs phosphate-buffered saline control, P < .001) 4 months after vaccination as well as HPV-16 L1 VLPs [PubMed: 19470949]." ;
    rdfs:label "HPV L2" ;
    rdfs:seeAlso "Protegen ID: 510; NCBI Gene GI: 1489081; NCBI Protein GI: 9627107; NCBI Protein Accession: NP_041331; NCBITaxon: 333760" ;
    rdfs:subClassOf obo:VO_0010786, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011107
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "E6" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice vaccinated with pNGVL4a-E6/opt are able to generate potent protective and therapeutic antitumor effects against challenge with E6-expressing tumor cell line, TC-1 of HPV [PubMed: 16649071]." ;
    rdfs:label "HPV E6" ;
    rdfs:seeAlso "Protegen ID: 511; NCBI Gene GI: 1489078; NCBI Protein GI: 9627104; NCBI Protein Accession: NP_041325; NCBITaxon: 333760" ;
    rdfs:subClassOf obo:VO_0010786, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011108
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "L1" ;
    a owl:Class ;
    rdfs:comment "rAAV5, -8 and -9 vectors expressing an HPV16 L1/E7 fusion gene were generated and applied intranasally for combined prophylactic and therapeutic vaccination of mice.  Vaccination with the rAAV vectors led to a significant protection of animals against a challenge with different HPV tumour cell lines [PubMed: 20032542]." ;
    rdfs:label "HPV L1" ;
    rdfs:seeAlso "Protegen ID: 512; NCBI Gene GI: 1489082; NCBI Protein GI: 9627108; NCBI Protein Accession: NP_041332; NCBITaxon: 333760" ;
    rdfs:subClassOf obo:VO_0010786, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011109
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The DNA vaccine pIHNw-G encodes the glycoprotein of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV). Vaccine performance in rainbow trout was measured 3, 6, 13, 24, and 25 months after vaccination. At three months all fish vaccinated with 0.1 microg pIHNw-G had detectable neutralizing antibody (NAb) and they were completely protected from lethal IHNV challenge with a relative percent survival (RPS) of 100% compared to control fish [PubMed: 16154239]." ;
    rdfs:label "G glycoprotein" ;
    rdfs:seeAlso "Protegen ID: 513; NCBI Gene GI: 1489848; NCBI Protein GI: 9628086; NCBI Protein Accession: NP_042679; NCBITaxon: 11290" ;
    rdfs:subClassOf obo:VO_0010810, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011110
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined with A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge [PubMed: 8621928]." ;
    rdfs:label "NP from Influenza B virus" ;
    rdfs:seeAlso "Protegen ID: 514; NCBI Gene GI: 956539; NCBI Protein GI: 8486155; NCBI Protein Accession: NP_056661; NCBITaxon: 11520" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011111
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined with A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge [PubMed: 8621928]." ;
    rdfs:label "NP from Influenza A virus H3N2" ;
    rdfs:seeAlso "Protegen ID: 515; NCBI Protein GI: 3722159; NCBITaxon: 41857" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011112
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Skin and mucosal vaccination provided complete protection from clinical signs of infection with ponies subjected to a challenge infection of Equine influenza virus, while skin vaccination provided partial protection; DNA vaccination provided partial protection from viral shedding [PubMed: 10403592]." ;
    rdfs:label "HA from Equine influenza virus H3N8" ;
    rdfs:seeAlso "Protegen ID: 516; NCBI Protein GI: 404517; NCBITaxon: 31660" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011113
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A nonpathogenic vector of the cytoplasmic domain of the VSV G protein and expressing influenza virus HA (derived from Influenza A virus (A/WSN/1933(H1N1))) provides complete protection from lethal influenza virus challenge after intranasal administration. A second vector with VSV G deleted and expressing HA (DeltaG-HA) is also protective and nonpathogenic and has the advantage of not inducing neutralizing antibodies to the vector itself [PubMed: 10196265]." ;
    rdfs:label "HA from Influenza A virus (A/WSN/1933(H1N1))" ;
    rdfs:seeAlso "Protegen ID: 518; NCBI Protein GI: 324200; NCBITaxon: 382835" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011114
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A recombinant baculovirus expressing the hemagglutinin gene of the influenza virus, A/PR/8/34 (H1N1), under the control of the chicken beta-actin promoter, was constructed.  Protection from a lethal challenge of the influenza virus was achieved by intranasal immunization of the recombinant baculovirus [PubMed: 12874198]." ;
    rdfs:label "HA from Influenza A virus (A/Puerto Rico/8/1934(H1N1))" ;
    rdfs:seeAlso "Protegen ID: 519; NCBI Protein GI: 126599271; NCBITaxon: 211044" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011115
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Two cyclic peptide analogues corresponding to residues 139-146 (site A) of influenza A virus haemagglutinin (strain X31) were synthesized.  When OF1 mice were immunized with cyclic peptides, approximately 80% of the animals were protected against an intranasal challenge with influenza virus [PubMed: 2396470]." ;
    rdfs:label "HA from Influenza A virus (A/Aichi/2/1968(H3N2)), (X31)" ;
    rdfs:seeAlso "Protegen ID: 520; NCBI Protein GI: 324132; NCBITaxon: 387139" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011116
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice and ferrets were immunised with two doses of the split virus vaccine (12-24 microg haemagglutinin derived from Influenza A virus (A/chicken/Italy/13474/99(H7N1))) with or without aluminium hydroxide adjuvant and challenged 3 weeks after second dose with the highly pathogenic A/chicken/Italy/13474/99 (H7N1) virus.  The vaccine induced significant protection from disease after challenge with the wild-type virus. In the murine lethal challenge model, vaccination effectively prevented death and, furthermore, formulation with adjuvant reduced excessive weight loss and viral shedding [PubMed: 19453487]." ;
    rdfs:label "HA from Influenza A virus (A/chicken/Italy/13474/99(H7N1))" ;
    rdfs:seeAlso "Protegen ID: 521; NCBI Protein GI: 32261025; NCBITaxon: 199442" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011117
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization and challenge experiments in mice indicated that even though vaccination with the recombinant HA vaccinia viruses derived from Influenza B virus (Strain B/England/222/82) induced different levels of cross-reactive neutralizing antibodies, mice vaccinated with either recombinant vaccinia virus were protected from infection with either subpopulation of influenza virus [PubMed: 3318092]." ;
    rdfs:label "HA from Influenza B virus (Strain B/England/222/82)" ;
    rdfs:seeAlso "Protegen ID: 522; NCBI Protein GI: 122955; NCBITaxon: 11527" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011118
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with a recombinant VLP vaccine from both influenza A H5N1 clade 1 and clade 2 isolates (Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))) with pandemic potential were protected against challenge with lethal reassortant viruses expressing the H5N1 HA and NA, regardless if the H5N1 clade was homologous or heterologous to the vaccine [PubMed: 18231588]." ;
    rdfs:label "HA from Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 523; NCBI Protein GI: 190344179; NCBITaxon: 389226" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011119
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A targeted fusion protein based on the CTA1-DD adjuvant and containing tandem repeats of the matrix protein 2 (M2e) ectodomain epitope derived from Influenza A virus (A/Puerto Rico/8/34(H1N1)), CTA1-3M2e-DD, confers strong protective immunity against a potentially lethal challenge infection with influenza virus in mice. The formulation was highly effective for mucosal immunizations and promoted high M2e-specific serum IgG and mucosal IgA antibody titers and an hitherto unknown anti-M2e CD4 T cell immunity [PubMed: 18243429]." ;
    rdfs:label "M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1))" ;
    rdfs:seeAlso "Protegen ID: 524; NCBI Gene GI: 956528; NCBI Protein GI: 56583270; NCBI Protein Accession: NP_040979; NCBITaxon: 211044" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011120
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination with HA-VRP derived from Influenza A virus (A/Hong Kong/1/68(H3N2)) did not strongly stimulate either neutralizing or IgG1 antibodies but did induce IgG2a antibodies. Expression of IgG2a antibodies in this context correlated with clearance of virus and increased protection against lethal influenza challenge [PubMed: 16960108]." ;
    rdfs:label "HA from Influenza A virus (A/Hong Kong/1/68(H3N2))" ;
    rdfs:seeAlso "Protegen ID: 525; NCBI Protein GI: 16960108; NCBITaxon: 10090" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011121
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers report that a DNA vaccine encoding hemagglutinin from the index human influenza isolate A/HK/156/97 provides immunity against H5N1 infection of mice [PubMed: 9971791]." ;
    rdfs:label "HA from Influenza A virus (A/environment/Hong Kong/156/1997(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 527; NCBI Protein GI: 269826115; NCBITaxon: 680785" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011122
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A simian adenovirus 24 (AdC7) vector expressing the influenza A/Puerto Rico/8/34 NP was tested for its efficacy in protecting BALB/c mice against two H5N1 strains.  When tested in a mouse challenge model, there was a significantly improved survival rate following challenge with the Vietnam/1203/04 strain of H5N1 that has caused human outbreaks [PubMed: 17728024]." ;
    rdfs:label "NP from Influenza A virus (A/Puerto Rico/8/34(H1N1))" ;
    rdfs:seeAlso "Protegen ID: 528; NCBI Gene GI: 956531; NCBI Protein GI: 8486130; NCBI Protein Accession: NP_040982; NCBITaxon: 211044" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011123
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The protective effect of neuraminidase (NA) was studied in a mouse protection test using isolated neuraminidase of A2/Aichi/68(H3N2) virus and the complete recombinant virus A/eq(Heq-1)-HK(N2) as antigens. Immunized mice were protected against A2/Aichi(H3N2) challenge virus; however, the protection rate was low in comparison to animals immunized with comparable amounts of the complete A2/68(H3N2) virus9 [PubMed: 1126575]." ;
    rdfs:label "NA from Influenza A virus (A/Aichi/2/1968(H3N2))" ;
    rdfs:seeAlso "Protegen ID: 530; NCBI Protein GI: 46401580; NCBITaxon: 387139" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011124
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In mouse models of influenza infection, the vaccines derived from Influenza A virus (A/Solomon Islands/3/2006(H1N1)) hemagglutinin elicit robust antibody responses that mitigate disease and protect mice from lethal challenge [PubMed: 18493310]." ;
    rdfs:label "HA from Influenza A virus (A/Solomon Islands/3/2006(H1N1))" ;
    rdfs:seeAlso "Protegen ID: 531; NCBI Protein GI: 156123416; NCBITaxon: 464623" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011125
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Results indicated that two doses of 10 microg of pCAGGoptiHA derived from Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) could induce complete protection in chickens against H5 lethal virus challenge [PubMed: 17451817]." ;
    rdfs:label "HA from Influenza A virus (A/Goose/Guangdong/1/96(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 532; NCBI Gene GI: 3654620; NCBI Protein GI: 73852955; NCBI Protein Accession: YP_308669; NCBITaxon: 93838" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011126
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The inoculation of HA vaccine prepared from influenza viruses A/Yamagata/120/86 (H1N1) or A/Fukuoka/C29/85 (H3N2) together with CTB provided partial protection against PR-8 infection in Balb/c mice [PubMed: 2781859]." ;
    rdfs:label "HA from Influenza A virus (A/Yamagata/120/1986(H1N1))" ;
    rdfs:seeAlso "Protegen ID: 533; NCBI Protein GI: 221344; NCBITaxon: 379740" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011127
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The inoculation of HA vaccine prepared from influenza viruses A/Yamagata/120/86 (H1N1) or A/Fukuoka/C29/85 (H3N2) together with CTB provided partial protection against PR-8 infection in Balb/c mice [PubMed: 2781859]." ;
    rdfs:label "HA from Influenza A virus (A/Fukuoka/C29/85(H3N2))" ;
    rdfs:seeAlso "Protegen ID: 534; NCBI Protein GI: 221306; NCBITaxon: 62549" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011128
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protection against a lethal influenza B virus infection was examined in BALB/c mice immunized with plasmid DNAs encoding hemagglutinin (HA), neuraminidase (NA and NB) and nucleoprotein (NP) from the B/Ibaraki/2/85 virus.  Both HA and NA DNAs conferred complete protection against the lethal challenge in all the tested mouse strains [PubMed: 11163667]." ;
    rdfs:label "HA from Influenza B virus (B/Ibaraki/2/85)" ;
    rdfs:seeAlso "Protegen ID: 535; NCBI Protein GI: 122959; NCBITaxon: 107411" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011129
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protection against a lethal influenza B virus infection was examined in BALB/c mice immunized with plasmid DNAs encoding hemagglutinin (HA), neuraminidase (NA and NB) and nucleoprotein (NP) from the B/Ibaraki/2/85 virus.  Both HA and NA DNAs conferred complete protection against the lethal challenge in all the tested mouse strains [PubMed: 11163667]." ;
    rdfs:label "NA from Influenza B virus (B/Ibaraki/2/85)" ;
    rdfs:seeAlso "Protegen ID: 536; NCBI Protein GI: 53829726; NCBITaxon: 107411" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011130
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Viral challenge studies showed that live BacHA derived from Influenza A virus (A/Indonesia/CDC669/2006(H5N1)) was able to provide 100% protection against 5 50% mouse lethal doses (MLD(50)) of homologous (clade 2.1) and heterologous (clade 1) H5N1 [PubMed: 20071572]." ;
    rdfs:label "HA from Influenza A virus (A/Indonesia/CDC669/2006(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 537; NCBI Protein GI: 113497156; NCBITaxon: 400828" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011131
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Viral challenge studies showed that live BacHA derived from Influenza A virus (A/Indonesia/CDC594/2006(H5N1)) was able to provide 100% protection against 5 50% mouse lethal doses (MLD(50)) of homologous (clade 2.1) and heterologous (clade 1) H5N1 [PubMed: 20071572]." ;
    rdfs:label "HA from Influenza A virus (A/Indonesia/CDC594/2006(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 538; NCBI Protein GI: 113495780; NCBITaxon: 400810" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011132
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A DNA vaccine encoding HA (from Influenza A virus (A/Hawaii/01/1991(H3N2))), NP and M1 (from a 1989 strain) protected ferrets better against challenge with the antigenic drift variant A/Georgia/03/93 than did the inactivated vaccine from the 1992-93 influenza season. Researchers report that the same DNA vaccine protected ferrets against a second, further divergent, drift variant (A/Johannesburg/33/94) [PubMed: 9234535]." ;
    rdfs:label "HA from Influenza A virus (A/Hawaii/01/1991(H3N2))" ;
    rdfs:seeAlso "Protegen ID: 539; NCBI Protein GI: 110313990; NCBITaxon: 387158" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011133
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with HA plasmid once and the NA plasmid twice survived 100% [PubMed: 19067149]." ;
    rdfs:label "HA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 540; NCBI Protein GI: 61698018; NCBITaxon: 319102" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011134
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with NP plasmid showed 60-80% survival rate with at least three immunizations.  The mixture of M1 and NP plasmids protected 95% of the mice against the homologous virus, and 80% of the mice against a challenge with heterologous H1N1 (PR8) virus [PubMed: 19067149]." ;
    rdfs:label "NP from Influenza A virus (A/chicken/Henan/12/2004(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 541; NCBI Protein GI: 61698066; NCBITaxon: 319102" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011135
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later.  The mice immunized with HA plasmid once and the NA plasmid twice survived 100% [PubMed: 19067149]." ;
    rdfs:label "NA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 542; NCBI Protein GI: 61698053; NCBITaxon: 319102" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011136
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later.  The mice immunized with M1 plasmid survived 25% with five immunizations.  The mixture of M1 and NP plasmids protected 95% of the mice against the homologous virus, and 80% of the mice against a challenge with heterologous H1N1 (PR8) virus [PubMed: 19067149]." ;
    rdfs:label "M1 from Influenza A virus (A/chicken/Henan/12/2004(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 543; NCBI Protein GI: 61698034; NCBITaxon: 319102" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011137
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination with ptPAs/NP derived from Influenza A virus (A/chicken/Hubei/489/2004(H5N1)) efficiently cleared the homologous H5N1 influenza virus in the infected lungs and induced partial cross-protection against heterologous, highly pathogenic H5N1 strains in mice [PubMed: 18789973]." ;
    rdfs:label "NP from Influenza A virus (A/chicken/Hubei/489/2004(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 544; NCBI Protein GI: 55233233; NCBITaxon: 298603" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011138
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers evaluated the immunogenicity and efficacy of a panel of flagellin-based hemagglutinin (HA) globular head fusion vaccines in inbred mice. The HA globular head of these vaccines was derived from the A/Vietnam/1203/04 (VN04; H5N1) HA molecule. Results show that replacement of domain D3 of flagellin with the VN04 HA globular head creates a highly effective vaccine that elicits protective HAI titers which protect mice against disease and death in a lethal challenge model with H5 VN virus [PubMed: 19654064]." ;
    rdfs:label "HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 545; NCBI Protein GI: 159144921; NCBITaxon: 284218" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011139
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Using reverse genetics, we constructed a recombinant NDV expressing an H9 AIV hemagglutinin (HA) from an H9N2 field isolate, A/Chicken/ Shandong/2/2007.  When tested, 90% of chickens were protected from clinical disease, mortality, and virus shedding against challenge with homologous H9N2 AIV [PubMed: 20521648]." ;
    rdfs:label "HA from Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))" ;
    rdfs:seeAlso "Protegen ID: 546; NCBI Protein GI: 206812650; NCBITaxon: 563925" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011140
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with DNA/rAd5 vaccines encoding HA derived from Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) conferred protection in ferrets against a stringent virus challenge [PubMed: 20352112]." ;
    rdfs:label "HA from Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 547; NCBI Nucleotide GI: 46578137; NCBI Protein GI: 46578138; NCBI Protein Accession: AAS65615.2; NCBITaxon: 266827" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011141
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "All  specific-pathogen-free chickens immunized with (vFP89) expressing the native hemagglutinin (HA) gene from H5N8 A/turkey/ Ireland/1378/83 were clinically protected from HPAI challenge [PubMed: 20521642]." ;
    rdfs:label "HA from Influenza A virus (A/turkey/Ireland/1378/1983(H5N8))" ;
    rdfs:seeAlso "Protegen ID: 549; NCBI Protein GI: 115279333; NCBITaxon: 380285" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011142
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "All specific-pathogen-free chickens immunized with (vFP2211) expressing a modified synthetic HA gene from H5N1 A/chicken/Indonesia/7/2003 were clinically protected from HPAI challenge [PubMed: 20521642]." ;
    rdfs:label "HA from Influenza A virus (A/chicken/Indonesia/7/2003(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 550; NCBI Protein GI: 129282887; NCBITaxon: 430432" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011143
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A neutralizing monoclonal antibody (mAb) 9F4 against the hemagglutinin (HA) of the influenza A/chicken/hatay/2004 H5N1 virus was generated.   MAb 9F4 was found to be protective, both prophylactically and therapeutically, against lethal viral challenge of mice [PubMed: 20519402]." ;
    rdfs:label "HA from Influenza A virus (A/Hatay/2004/(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 551; NCBI Protein GI: 56311402; NCBITaxon: 303316" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011144
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Chickens immunized with attenuated Salmonella strains expressing the hemagglutinin (HA1) gene from a highly pathogenic avian influenza (HPAI) H5N1 (A/whooper swan/Mongolia/3/2005) demonstrated a statistically significant increase in survival compared to control groups [PubMed: 20406663]." ;
    rdfs:label "HA from Influenza A virus (A/whooper swan/Mongolia/3/05(H5N1))" ;
    rdfs:seeAlso "Protegen ID: 553; NCBI Protein GI: 81687119; NCBITaxon: 344596" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011145
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers constructed a recombinant pseudotype baculovirus encoding the JEV envelope (E) protein and demonstrated that it could elicit high protective immunity in mice.  Intramuscular injections of BV-G-E at various doses into mice produced higher levels of JEV-specific neutralizing antibodies, IFN-gamma and better protective efficacy against a lethal challenge with JEV than that of pc-E. Furthermore, BV-G-E could elicit a higher level of cellular immunity response and provide equal protective efficacy against JEV challenge compared to inactivated vaccine [PubMed: 19006097]." ;
    rdfs:label "Envelope protein" ;
    rdfs:seeAlso "Protegen ID: 554; NCBI Protein GI: 16445023; NCBITaxon: 11072" ;
    rdfs:subClassOf obo:VO_0010783, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011146
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers established a simple and effective method for DNA immunization against Japanese encephalitis virus (JEV) infection with plasmids encoding the viral PrM and E proteins and colloidal gold.   After being inoculated twice, BALB/c mice were found to resist challenge with 100,000 times the 50% lethal dose (LD(50)) of JEV (Beijing-1 strain) even when immunized with a relatively small dose of 0.5 micro g of plasmid DNA [PubMed: 12634382]." ;
    rdfs:label "PrM" ;
    rdfs:seeAlso "Protegen ID: 555; NCBI Protein GI: 90019439; NCBITaxon: 11072" ;
    rdfs:subClassOf obo:VO_0010783, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011147
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Balb/c mice and swine vaccinated with TK(-)/gG(-)/NS1(+) expressing NS1 protein of JEV could confer protective immunity against lethal challenge of the virulent PRV Ea strain and develop a good humoral and cellular immune response against JEV [PubMed: 15121294]." ;
    rdfs:label "NS1" ;
    rdfs:seeAlso "Protegen ID: 556; NCBI Protein GI: 18418672; NCBITaxon: 11072" ;
    rdfs:subClassOf obo:VO_0010783, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011148
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers constructed plasmid DNAs encoding JE virus proteins.  Cytotoxic T lymphocytes (CTLs) were induced by NS3 in a mouse model.  Three immunizations with pUJENS3 provided a 50% partial protection from a lethal dose of JE virus [PubMed: 12922097]." ;
    rdfs:label "NS3" ;
    rdfs:seeAlso "Protegen ID: 557; NCBI Protein GI: 27696332; NCBITaxon: 11072" ;
    rdfs:subClassOf obo:VO_0010783, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011149
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers constructed plasmid DNAs encoding JE virus proteins. Cytotoxic T lymphocytes (CTLs) were induced by NS5 in a mouse model. Three immunizations with pUJENS5 provided a 57% partial protection from a lethal dose of JE virus [PubMed: 12922097]." ;
    rdfs:label "NS5" ;
    rdfs:seeAlso "Protegen ID: 558; NCBI Protein GI: 158702649; NCBITaxon: 11072" ;
    rdfs:subClassOf obo:VO_0010783, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011150
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A cDNA clone representing the genome of structural proteins of Japanese encephalitis virus (JEV) was inserted into the thymidine kinase gene of vaccinia virus strains LC16mO and WR.  Inoculation of rabbits with the infectious recombinant vaccinia virus resulted in rapid production of antiserum specific for the PreM and E glycoproteins of JEV.  Mice vaccinated with the recombinant produced JEV-neutralizing antibodies and were resistant to challenge with JEV [PubMed: 2159544]." ;
    rdfs:label "PreM" ;
    rdfs:seeAlso "Protegen ID: 559; NCBI Protein GI: 14600066; NCBITaxon: 11072" ;
    rdfs:subClassOf obo:VO_0010783, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011151
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccine efficacy trials in guinea pigs indicated that the nucleoprotein is capable of eliciting a protective immune response against a lethal dose of Lassa virus. Ninety-four percent of the animals vaccinated with V-LSN survived a Lassa virus challenge in which only 14% of unvaccinated animals and 39% of animals vaccinated with the New York Board of Health (NYBH) strain of vaccinia virus survived [PubMed: 2741340]." ;
    rdfs:label "LASVsSgp1 nucleoprotein" ;
    rdfs:seeAlso "Protegen ID: 560; NCBI Gene GI: 956584; NCBI Protein GI: 23343510; NCBI Protein Accession: NP_694869; NCBITaxon: 11620" ;
    rdfs:subClassOf obo:VO_0010763, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011152
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized with a vaccine expressing the 78kDa (GRP-78) antigen of Leishmania donovani. Challenge infection was given intracardially after 2 weeks of second booster. A significant decrease in parasite burden was seen in vaccinees over the infected controls on all post challenge days and was found that maximum protection was provided by 78kDa+rIL-12 vaccine.  It was highly immunogenic as depicted by the reduction in parasite load (71-94.8%) [PubMed: 20093205]." ;
    rdfs:label "GRP-78" ;
    rdfs:seeAlso "Protegen ID: 561; NCBI Protein GI: 16797868; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011153
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study results show that a single intraperitoneal administration of the A2-recombinant L. tarentolae strain expressing the Leishmania donovani A2 antigen protects BALB/c mice against L. infantum challenge and that protective immunity is associated with high levels of IFN-gamma production prior and after challenge [PubMed: 19818721]." ;
    rdfs:label "A2" ;
    rdfs:seeAlso "Protegen ID: 563; NCBI Protein GI: 30385439; NCBITaxon: 5671" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011154
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study compared the vaccine efficacy of various L. donovani antigens encapsulated in cationic liposomes in BALB/c mice against challenge infection with L. donovani.  Results demonstrated that liposomal LD31 (ATP synthase alpha chain) reduced parasite burden by 74%-77% [PubMed: 19503834]." ;
    rdfs:label "F1-ATPase" ;
    rdfs:seeAlso "Protegen ID: 564; NCBI Protein GI: 722242; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011155
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study compared the vaccine efficacy of various L. donovani antigens encapsulated in cationic liposomes in BALB/c mice against challenge infection with L. donovani. Results demonstrated that liposomal LD51 (beta-tubulin) reduced parasite burden by 72%-75% [PubMed: 19503834]." ;
    rdfs:label "Beta-tubulin" ;
    rdfs:seeAlso "Protegen ID: 565; NCBI Protein GI: 262233287; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011156
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study compared the vaccine efficacy of various L. donovani antigens encapsulated in cationic liposomes in BALB/c mice against challenge infection with L. donovani. Results demonstrated that liposomal LD72 (Hsp70) reduced parasite burden by 65%-67% [PubMed: 19503834]." ;
    rdfs:label "Hsp70" ;
    rdfs:seeAlso "Protegen ID: 566; NCBI Protein GI: 281426606; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011157
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "KMP-11 DNA vaccination alone in an experimental BALB/c mice model showed significant potential in terms of resolution of splenic and hepatic parasite burden against virulent LD challenge.  KMP-11 DNA immunization significantly protects against L. donovani infection [PubMed: 19162111]." ;
    rdfs:label "KMP-11" ;
    rdfs:seeAlso "Protegen ID: 567; NCBI Protein GI: 7579896; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011158
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study showed that cationic distearoyl phosphatidylcholine (DSPC) liposomes, when used as vaccine adjuvant with the immunodominant 63-kDa glycoprotein (gp63, mspC) of Leishmania donovani promastigotes, induced significant protection against progressive visceral leishmaniasis in susceptible BALB/c mice. gp63 used without adjuvant elicited partial protection but in association with liposomes exhibited marked resistance in both the livers and spleens of the mice challenged 10 days after the last vaccination [PubMed: 18195029]." ;
    rdfs:label "MspC" ;
    rdfs:seeAlso "Protegen ID: 568; NCBI Protein GI: 21954466; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011159
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "An expression plasmid encoding both p35 and p40 subunits of IL-12 when co-administered with a recombinant open-reading frame (rORFF) gene from the LD1 locus of Leishmania donovani induces significant protection with around 82% protection in both liver and spleen of BALB/c mice when challenged with L. donovani [PubMed: 16413950]." ;
    rdfs:label "ORFF" ;
    rdfs:seeAlso "Protegen ID: 569; NCBI Protein GI: 703122; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011160
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization of mice with recombinant BT1 proteins (a biopterin transporter) from multigenic LD1 locus on chromosome 35 of L. donovani conferred partial protection against challenge with Leishmania donovani in a BALB/c mice [PubMed: 15357215]." ;
    rdfs:label "BT1" ;
    rdfs:seeAlso "Protegen ID: 570; NCBI Protein GI: 703123; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011161
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Experimental infection of immunized BALB/c mice demonstrated that the VR1012-NH36 DNA vaccine derived from the nucleoside hydrolase gene (NH) of L. donovani induced an 88% reduction in L. chagasi parasite load and a 65% reduction in L. mexicana lesion size [PubMed: 15664920]." ;
    rdfs:label "NH" ;
    rdfs:seeAlso "Protegen ID: 571; NCBI Protein GI: 19697561; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011162
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study demonstrated for the first time that a recombinant stage-specific hydrophilic surface protein of Leishmania donovani, recombinant hydrophilic acylated surface protein B1 (HASPB1), is able to confer protection against experimental challenge with L. donovani in BALB/c mice [PubMed: 11120835]." ;
    rdfs:label "L. donovani HASPB1" ;
    rdfs:seeAlso "Protegen ID: 572; NCBI Protein GI: 51847753; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010832, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011163
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Nonhuman primates (cynomolgus macaques) were inoculated with VEE replicons expressing MBGV GP and/or NP and challenged with MGBV.  MBGV NP afforded incomplete (partial) protection, sufficient to prevent death but not disease in two of three macaques [PubMed: 9813200 ]." ;
    rdfs:label "NP from Lake Victoria marburgvirus" ;
    rdfs:seeAlso "Protegen ID: 573; NCBI Protein GI: 332181; NCBITaxon: 11269" ;
    rdfs:subClassOf obo:VO_0010769, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011164
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV, Gallid herpesvirus 2).  rFPV/gB1 expressing MDV040 conferred 42% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates [PubMed: 14562881]." ;
    rdfs:label "MDV040" ;
    rdfs:seeAlso "Protegen ID: 574; NCBI Gene GI: 4811501; NCBI Protein GI: 125745079; NCBI Protein Accession: YP_001033956; NCBITaxon: 10390" ;
    rdfs:subClassOf obo:VO_0010804, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011165
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV, Gallid herpesvirus 2). rFPV/gI expressing MDV095 conferred 43% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates [PubMed: 14562881]." ;
    rdfs:label "MDV095" ;
    rdfs:seeAlso "Protegen ID: 575; NCBI Gene GI: 4811454; NCBI Protein GI: 125745128; NCBI Protein Accession: YP_001034012; NCBITaxon: 10390" ;
    rdfs:subClassOf obo:VO_0010804, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011166
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Chimeric Venezuelan equine encephalitis/Sindbis virus (VEE/SIN) replicon particles were used to express the hemagglutinin (H) and fusion (F) proteins of measles virus (MV).  When challenged with wild-type MV 12 to 17 months after vaccination, all vaccinated juvenile and infant monkeys vaccinated with VEE/SIN-H, VEE/SIN-H+F, and LAV were protected from rash and viremia [PubMed: 20130066]." ;
    rdfs:label "H hemagglutinin protein" ;
    rdfs:seeAlso "Protegen ID: 577; NCBI Gene GI: 1489801; NCBI Protein GI: 9626951; NCBI Protein Accession: NP_056923; NCBITaxon: 11234" ;
    rdfs:subClassOf obo:VO_0010784, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011167
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with a vaccinia virus recombinant encoding the fusion protein of Measles virus developed measles neutralizing antibodies.  The mice also resisted a normally lethal intracerebral inoculation of a cell-associated measles virus subacute sclerosing panencephalitis strain [PubMed: 3422488]." ;
    rdfs:label "F fusion protein" ;
    rdfs:seeAlso "Protegen ID: 578; NCBI Gene GI: 1489800; NCBI Protein GI: 9626950; NCBI Protein Accession: NP_056922; NCBITaxon: 11234" ;
    rdfs:subClassOf obo:VO_0010784, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011168
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Lewis rats were immunized with recombinant vaccinia virus (VV) expressing various proteins of measles virus (MV). VVN (Nucleocapsid Protein) -immunized rats survived a MV challenge infection [PubMed: 1833505]." ;
    rdfs:label "N nucleocapsid protein" ;
    rdfs:seeAlso "Protegen ID: 579; NCBI Gene GI: 1489804; NCBI Protein GI: 9626946; NCBI Protein Accession: NP_056918; NCBITaxon: 11234" ;
    rdfs:subClassOf obo:VO_0010784, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011169
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Lewis rats were immunized with recombinant vaccinia virus (VV) expressing various proteins of measles virus (MV). VVP (Phosphoprotein) -immunized rats were partially protected from MV challenge [PubMed: 1833505]." ;
    rdfs:label "P phosphoprotein" ;
    rdfs:seeAlso "Protegen ID: 580; NCBI Gene GI: 1489805; NCBI Protein GI: 9626947; NCBI Protein Accession: NP_056919; NCBITaxon: 11234" ;
    rdfs:subClassOf obo:VO_0010784, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011170
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Lewis rats were immunized with recombinant vaccinia virus (VV) expressing various proteins of measles virus (MV). VVM (Matrix Protein) -immunized rats were partially protected from MV challenge [PubMed: 1833505]." ;
    rdfs:label "M matrix protein" ;
    rdfs:seeAlso "Protegen ID: 581; NCBI Gene GI: 1489803; NCBI Protein GI: 9626949; NCBI Protein Accession: NP_056921; NCBITaxon: 11234" ;
    rdfs:subClassOf obo:VO_0010784, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011171
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A novel mumps vaccine with good immunity and safety was developed by selecting an antigen (HN) component of the mumps virus. The clinical and pathological observations after challenge of vaccinated rhesus monkeys indicated further that the immune response induced by this vaccine provided complete protection from wild-type virus infection [PubMed: 18597904]." ;
    rdfs:label "HN" ;
    rdfs:seeAlso "Protegen ID: 582; NCBI Gene GI: 1489765; NCBI Protein GI: 9695422; NCBI Protein Accession: NP_054713; NCBITaxon: 11161" ;
    rdfs:subClassOf obo:VO_0010785, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011172
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with DNA encoding Ag85B (fbpB), a candidate vaccine antigen of Mycobacterium tuberculosis, elicited in mice a low but protective CD4(+) T cell-mediated IFN-gamma response [PubMed: 20544034]." ;
    rdfs:label "FbpB from M. tuberculosis" ;
    rdfs:seeAlso "Protegen ID: 583; NCBI Gene GI: 885785; NCBI Protein GI: 15609023; NCBI Protein Accession: NP_216402; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011173
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Our lead construct, Mtb72F, codes for a 72-kDa polyprotein genetically linked in tandem in the linear order Mtb32(C)-Mtb39-Mtb32(N).  All forms of Mtb72F immunization tested resulted in the protection of C57BL/6 mice against aerosol challenge with a virulent strain of M. tuberculosis [PubMed: 15187142]." ;
    rdfs:label "Mtb72F" ;
    rdfs:seeAlso "Protegen ID: 584; NCBI Protein GI: 283801990; NCBITaxon: 32630" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011174
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protective experiments of DNA vaccine pcDNA3-MIC3 (pMIC3i) in Kumming mice showed that the vaccine could significantly prolong the survival time of the mice challenged by virulent RH strains of T. gondii [PubMed: 19800170]." ;
    rdfs:label "MIC3" ;
    rdfs:seeAlso "Protegen ID: 587; NCBI Gene GI: 7901253; NCBI Protein GI: 237841071; NCBI Protein Accession: XP_002369833; NCBITaxon: 508771" ;
    rdfs:subClassOf obo:VO_0010826, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011175
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "We show that the 50- to 55-kDa Apa protein, specified by the Rv1860 gene of M. tuberculosis, can elicit both lymphoproliferative response and gamma interferon (IFN-gamma) production.  A poxvirus recombinant expressing the Apa protein conferred a significant level of protective immunity in guinea pigs against a challenge dose of virulent M. tuberculosis [PubMed: 12654810]." ;
    rdfs:label "Apa" ;
    rdfs:seeAlso "Protegen ID: 588; NCBI Gene GI: 885896; NCBI Protein GI: 57116926; NCBI Protein Accession: YP_177849; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011176
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "MPT63 (Rv1926c), a major secreted protein of Mycobacterium tuberculosis, is immunoreactive in antibody assays in humans and animals and provides protection as a combined DNA vaccine in mice [PubMed: 19281533]." ;
    rdfs:label "Mpt63" ;
    rdfs:seeAlso "Protegen ID: 589; NCBI Gene GI: 885334; NCBI Protein GI: 15609063; NCBI Protein Accession: NP_216442; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011177
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The immunogenicity and protective efficacy of a recombinant subunit West Nile virus (WNV) vaccine was evaluated in rhesus macaques (Macaca mulatta). The vaccine consisted of a recombinant envelope (E) protein truncated at the C-terminal end, resulting in a polypeptide containing 80% of the N-terminal amino acids of the native WNV protein (WN-80E), mixed with an adjuvant (GPI-0100). Groups of monkeys were immunized with the WN-80E/GPI-0100 vaccine or an adjuvant-only control formulation. Animals were then challenged by inoculation of wild-type WNV, and the level of viremia in each animal was monitored daily for 10 days. The results showed that whereas all animals in the control group had detectable viremia for at least 3 days after challenge, all of the vaccinated animals were negative on all days after challenge. Thus, the WN-80E vaccine was 100% efficacious in protecting monkeys against infection with WNV [PubMed: 19641099]." ;
    rdfs:label "E protein" ;
    rdfs:seeAlso "Protegen ID: 590; NCBI Protein GI: 111145461; NCBITaxon: 11082" ;
    rdfs:subClassOf obo:VO_0010803, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011178
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "An antiserum raised in chicken against the TM-1 polypeptide, which was produced by recombinant Escherichia coli cells and purified by column chromatography, inhibited growth of M.g. cells in vitro. Moreover, chickens immunized with this 29 kDa polypeptide (TM-1) were partially protected from a challenge with virulent M.g [PubMed: 8212828]." ;
    rdfs:label "TM-1" ;
    rdfs:seeAlso "Protegen ID: 591; NCBI Protein GI: 7249262; NCBITaxon: 2096" ;
    rdfs:subClassOf obo:VO_0010819, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011179
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Starting with a previously designed eukaryotic expression vector, a recombinant plasmid (pCBWN) that expressed the WN virus prM and E proteins was constructed. A single intramuscular injection of pCBWN DNA induced protective immunity, preventing WN virus infection in mice and horses when subjected to challenge with the NY99-6480 strain of WNV [PubMed: 11287553]." ;
    rdfs:label "PrM" ;
    rdfs:seeAlso "Protegen ID: 592; NCBI Gene GI: 5714902; NCBI Protein GI: 158516888; NCBI Protein Accession: YP_001527877; NCBITaxon: 11082" ;
    rdfs:subClassOf obo:VO_0010803, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011180
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Seventeen monoclonal antibodies to one of three main cell surface antigens of Neisseria meningitidis group B were tested for protective efficacy in the infant rat using as challenge seven strains of different class 2/3 protein serotypes.  Survival of the animals was regularly obtained with antibodies to the P1 protein and to LPS [PubMed: 2510417]." ;
    rdfs:label "P1" ;
    rdfs:seeAlso "Protegen ID: 594; NCBI Gene GI: 902192; NCBI Protein GI: 15676020; NCBI Protein Accession: NP_273150; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011181
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Sera of the challenge group immunized with CCPS-P64kR showed a three-fold higher bactericidal response than the sera of the group immunized with the plain CCPS and they were able to protect against challenge with Neisseria meningococci in the infant rat protection model [PubMed: 15039094]." ;
    rdfs:label "LpdA" ;
    rdfs:seeAlso "Protegen ID: 596; NCBI Protein GI: 1017430; NCBITaxon: 487" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011182
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with purified Tbp2 survived a lethal challenge to a similar degree as animals immunized with the Tbp1-Tbp2 complex, demonstrating that Tbp2 played an important role in the protective activity observed with the complex, eliciting antibodies that are not only bactericidal but also inhibitory for meningococcal growth [PubMed: 7868259]." ;
    rdfs:label "TBP2" ;
    rdfs:seeAlso "Protegen ID: 597; NCBI Protein GI: 1017433; NCBITaxon: 487" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011183
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with recombinant forms of a sporozoite surface antigen (r-p67), derived from either bacterial or insect cells, induces high levels of sporozoite neutralizing antibodies in cattle.In vivo immunization studies have shown that approximately 30% of immunized cattle are nonreactors to a needle LD70 sporozoite challenge, 40% experience a mild disease reaction from which they recover, and the remaining 30% suffer severe disease and are clinically indistinguishable from controls. Transient parasitosis and mild clinical reactions are also observed in challenge of cattle immunized by infection and treatment and such responses constitute immunity to ECF. Hence, p67 is able to routinely induce immunity at a level of about 70% [PubMed: 11193661]." ;
    rdfs:label "P67" ;
    rdfs:seeAlso "Protegen ID: 598; NCBI Protein GI: 4106806; NCBITaxon: 5875" ;
    rdfs:subClassOf obo:VO_0010824, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011184
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "NspA-containing outer membrane vesicles conferred protection against otherwise lethal intraperitoneal challenge of mice with N. meningitidis serogroup B, and sera raised against them mediated opsonophagocytosis of meningococcal strains expressing this antigen [PubMed: 15501782]." ;
    rdfs:label "NspA from N. meningitidis" ;
    rdfs:seeAlso "Protegen ID: 599; NCBI Protein GI: 5825543; NCBITaxon: 487" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011185
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A total of 11 meningococcal proteins that are necessary for establishing systemic infection were expressed as recombinant antigens and assessed for their ability to protect mice against live bacterial challenge against N. meningitidis; the lactate permease (LctP) elicited protective immunity [PubMed: 15964482]." ;
    rdfs:label "LctP" ;
    rdfs:seeAlso "Protegen ID: 600; NCBI Protein GI: 254667969; NCBITaxon: 662598" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011186
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A total of 11 meningococcal proteins that are necessary for establishing systemic infection were expressed as recombinant antigens and assessed for their ability to protect mice against live bacterial challenge against N. meningitidis; ExbB, which is required for iron acquisition, elicited protective immunity [PubMed: 15964482]." ;
    rdfs:label "ExbB" ;
    rdfs:seeAlso "Protegen ID: 601; NCBI Gene GI: 903370; NCBI Protein GI: 15677575; NCBI Protein Accession: NP_274732; NCBITaxon: 122586" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011187
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The trial vaccination of cattle against T. annulata using recombinant sporozoite antigens (SPAG-1 and p67) and/or merozoite antigens (TAMS 1-1 and 1-2). The aim of these trials was to try and enhance the levels of protection induced compared with previous trials. Different approaches were tried. SPAG-1 was expressed as a fusion protein with a His6 tag and then either incorporated into ISCOMs, with or without TAMS 1-1 and 1-2, or administered with RWL, a proprietary saponin-based adjuvant. Cross-protection studies were also performed by immunizing cattle with the T. parva sporozoite antigen, p67, and then challenging with a T. annulata sporozoite stabilate.All the data collected from these two trials indicate that SPAG-1 administered with RWL is better at inducing an effective immune response than SPAG-1 incorporated into ISCOMs, with or without the presence of merozoite antigens [PubMed: 9668470]." ;
    rdfs:label "Spag-1" ;
    rdfs:seeAlso "Protegen ID: 602; NCBI Protein GI: 161885; NCBITaxon: 5874" ;
    rdfs:subClassOf obo:VO_0010825, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011188
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To test the potential of subunit vaccines against T. annulata infection, we immunized four groups of three calves with either recombinant (re-) (Tams1-1 and Tams1-2) proteins or naked DNA encoding these antigens. All calves vaccinated with ISCOMs proved to be protected from T. annulata infection and had generated antibodies against both re-(Tams1-1 and Tams1-2) at the time of challenge [PubMed: 9364686]." ;
    rdfs:label "TA17050 merozoite-piroplasm surface antigen Tams1" ;
    rdfs:seeAlso "Protegen ID: 603; NCBI Gene GI: 3864438; NCBI Protein GI: 84997996; NCBI Protein Accession: XP_953719; NCBITaxon: 353154" ;
    rdfs:subClassOf obo:VO_0010825, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011189
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intraperitoneal application of NcMAG1 suspended in saponin adjuvants lead to protection against disease in 50% of animals vaccinated in a C57Bl/6 mouse cerebral infection model [PubMed: 19835644]." ;
    rdfs:label "NcMAG1" ;
    rdfs:seeAlso "Protegen ID: 604; NCBI Protein GI: 147886433; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011190
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination with an RASV synthesizing full-length PsaA induced high titers of anti-PsaA antibodies in both systemic (IgG in serum) and mucosal (IgA in vaginal washes, nasal washes, and lung homogenates) sites. BALB/c (haplotype H2(d)) or C57BL/6 (haplotype H2(b)) mice vaccinated either orally or intranasally exhibited a significant reduction in colonization of nasopharyngeal tissues after intranasal challenge with S. pneumoniae strains compared to controls, although protection was not observed with all challenge strains. None of the vaccine constructs provided protection against intraperitoneal challenge with S. pneumoniae strain WU2 (serotype 3) [PubMed: 20479086]." ;
    rdfs:label "PsaA" ;
    rdfs:seeAlso "Protegen ID: 605; NCBI Protein GI: 209867628; NCBITaxon: 1313" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011191
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A 90% protection rate was achieved following intra-nasal vaccination with recNcPDI emulsified in cholera toxin employing the C57Bl/6 mouse cerebral infection model when challenged with Neospora caninum tachyzoites [PubMed: 19835644]." ;
    rdfs:label "NcPDI" ;
    rdfs:seeAlso "Protegen ID: 606; NCBI Protein GI: 82568727; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011192
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The protective effects a pneumolysin mutant (DeltaA146 Ply) against pneumococcal infections in mice was evaluated. Vaccinated mice were challenged with pneumococcal strain D39 at 1,500 times the LD50 (1.5 x 105 CFU) and the vaccinated mice survived significantly longer than control mice after challenge [PubMed: 20038538]." ;
    rdfs:label "Ply" ;
    rdfs:seeAlso "Protegen ID: 607; NCBI Gene GI: 4441611; NCBI Protein GI: 116515376; NCBI Protein Accession: YP_817150; NCBITaxon: 373153" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011193
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The protective effects of ATP-dependent caseinolytic protease (ClpP) was evaluated. Vaccinated mice were intraperitoneally and/or intranasally challenged with different pneumococcal strains. In intraperitoneal challenge models with pneumococcal strain D39 (serotype 2), clpP elicited some protection in mice [PubMed: 20038538]." ;
    rdfs:label "ClpP" ;
    rdfs:seeAlso "Protegen ID: 608; NCBI Gene GI: 4441476; NCBI Protein GI: 116516216; NCBI Protein Accession: YP_816144; NCBITaxon: 373153" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011194
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The production of a recombinant vaccine was achieved following PCR amplification of putative lipoate protein ligase (Lpl), with subsequent cloning and expression of the genes in E. coli. The putative lipoate protein ligase (Lpl) , resulted in a reduced CFU titre and a trend towards reduced mortality in an animal sepsis model [PubMed: 18034862]." ;
    rdfs:label "LplA" ;
    rdfs:seeAlso "Protegen ID: 609; NCBI Gene GI: 934072; NCBI Protein GI: 15903091; NCBI Protein Accession: NP_358641; NCBITaxon: 171101" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011195
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "NcSAG1 and NcSRS2, the two major immunodominant tachyzoite surface antigens of the apicomplexan parasite Neospora caninum, were investigated for their potential as vaccine candidates in mice.  Results suggest that a combined DNA/recombinant antigen-vaccine, based on NcSAG1 and NcSRS2, respectively, exhibited a highly significant protective effect against experimentally induced cerebral neosporosis in mice [PubMed: 12741509]." ;
    rdfs:label "NcSRS2" ;
    rdfs:seeAlso "Protegen ID: 610; NCBI Protein GI: 5579384; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011196
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "NcSAG1 and NcSRS2, the two major immunodominant tachyzoite surface antigens of the apicomplexan parasite Neospora caninum, were investigated for their potential as vaccine candidates in mice. Results suggest that a combined DNA/recombinant antigen-vaccine, based on NcSAG1 and NcSRS2, respectively, exhibited a highly significant protective effect against experimentally induced cerebral neosporosis in mice [PubMed: 12741509]." ;
    rdfs:label "NcSAG1" ;
    rdfs:seeAlso "Protegen ID: 611; NCBI Protein GI: 4583447; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011197
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant (r)PsrP(BR) had significantly less bacteria in their blood and improved survival versus controls following intranasal challenge [PubMed: 19627498]." ;
    rdfs:label "PsrP" ;
    rdfs:seeAlso "Protegen ID: 613; NCBI Gene GI: 7329552; NCBI Protein GI: 221232510; NCBI Protein Accession: YP_002511663; NCBITaxon: 561276" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011198
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """This study used an immunisation/challenge model of transplacental transmission, based on the Qs mouse with an Nc-Liverpool challenge to investigate the vaccine potential of a number of formulations based on four recombinant proteins of N. caninum.  A mixture of MIC10 and p24B produced partial protection against transplacental transmission of N. caninum in this mouse model [PubMed: 18789996].

Note:  MIC10 must be used in conjunction with p24B in order to confer protection against N. caninum.""" ;
    rdfs:label "MIC10" ;
    rdfs:seeAlso "Protegen ID: 614; NCBI Protein GI: 11141617; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011199
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intraperitoneal immunization with recombinant SrtA was found to have  conferred to mice protection against S. pneumoniae intraperitoneal challenge and the passive transfer of immune serum before intraperitoneal challenge was also protective. Moreover, by using the intranasal challenge model,  significant reduction of bacteremia when mice were intraperitoneally immunized with SrtA was observed, while a moderate decrease of lung infection was achieved by intranasal immunization, even though no influence on nasopharynx colonization was seen [PubMed: 19433540]." ;
    rdfs:label "SrtA" ;
    rdfs:seeAlso "Protegen ID: 615; NCBI Gene GI: 4442999; NCBI Protein GI: 116515518; NCBI Protein Accession: YP_816547; NCBITaxon: 373153" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011200
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study assessed the potential protectivity of NcMIC1-based vaccination against experimental N. caninum infection in mice.  Quantitative real-time PCR revealed that the infection intensity was significantly reduced in the group vaccinated with recNcMIC1 antigen.  Serological analysis showed that only recNcMIC1-immunized animals generated detectable antibody levels recognizing native NcMIC1. Thus, of all protocols applied, only recNcMIC1 vaccination appears to be suited to reduce cerebral infection in mice challenged with N. caninum tachyzoites [PubMed: 16108562]." ;
    rdfs:label "NcMIC1" ;
    rdfs:seeAlso "Protegen ID: 616; NCBI Protein GI: 17226315; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011201
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Glutamyl tRNA synthetase (GtS) has been found to be among the Streptococcus pneumoniae cell wall-derived proteins that have age-dependent immunogenicity in children. Here, GtS was cloned, expressed, and purified and then was used to immunize 7-week-old BALB/c OlaHsd mice. Thirty-nine percent of rGtS-immunized mice survived a lethal bacterial challenge, whereas no control mice survived [PubMed: 17703427]." ;
    rdfs:label "GltX" ;
    rdfs:seeAlso "Protegen ID: 617; NCBI Gene GI: 931970; NCBI Protein GI: 15901888; NCBI Protein Accession: NP_346492; NCBITaxon: 170187" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011202
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Separate groups of gerbils were immunized with purified recombinant proteins singly or in combinations and animals were then challenged with N. caninum.  The protective efficacy of each vaccination was determined by assessing animal survival rate.  The highest protection efficacy was observed for combined vaccination with NcSRS2 and NcDG1 (67.5% survival) compared to control (17.4% survival).  Vaccination with NcDG1 alone elicited 62.5% survival in the challenge model [PubMed: 15793355]." ;
    rdfs:label "NcDG1" ;
    rdfs:seeAlso "Protegen ID: 618; NCBI Protein GI: 2149142; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011203
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were actively immunized with a fragment of choline binding protein A (CbpA; also known as PspC, Hic, and SpsA). CbpA was able to protect mice from intraperitoneal challenge with medium to very high doses of a highly virulent capsular type 2 pneumococcal strain, D39 [PubMed: 11553536]." ;
    rdfs:label "CbpA" ;
    rdfs:seeAlso "Protegen ID: 619; NCBI Gene GI: 4441159; NCBI Protein GI: 116515359; NCBI Protein Accession: YP_817402; NCBITaxon: 373153" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011204
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Groups of BALB/c mice immunized with choline binding protein PspA were challenged with either D39 or WCH16. PspA elicited protection by using moderate challenge doses of S. pneumoniae [PubMed: 17088353]." ;
    rdfs:label "PspA" ;
    rdfs:seeAlso "Protegen ID: 620; NCBI Gene GI: 4441373; NCBI Protein GI: 116515876; NCBI Protein Accession: YP_815641; NCBITaxon: 373153" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011205
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Separate groups of gerbils were immunized with purified recombinant proteins singly or in combinations and animals were then challenged with N. caninum. The protective efficacy of each vaccination was determined by assessing animal survival rate.  All experimental groups showed protective effects.  Vaccination with NcDG2 alone elicited 50% survival rate compared to a control survival rate of 17.4% [PubMed: 15793355]." ;
    rdfs:label "NcDG2" ;
    rdfs:seeAlso "Protegen ID: 621; NCBI Protein GI: 3237325; NCBITaxon: 29176" ;
    rdfs:subClassOf obo:VO_0010828, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011206
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice were immunized with recombinant 6-Phosphogluconate dehydrogenase (r6PGD) and boosted after 3 weeks. Immunized mice were challenged intranasally with a lethal dose of S. pneumoniae. Immunization of mice with r6PGD protected 60% (P < 0.001) of mice for 5 days and 40% (P < 0.05) of the mice for 21 days following intranasal lethal challenge [PubMed: 16634799]." ;
    rdfs:label "Gnd" ;
    rdfs:seeAlso "Protegen ID: 622; NCBI Gene GI: 4441177; NCBI Protein GI: 116515453; NCBI Protein Accession: YP_815856; NCBITaxon: 373153" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011207
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant PiaA were protected against systemic challenge to a degree similar to those immunized with an existing protein vaccine candidate, PdB (a genetically modified pneumolysin toxoid). Immunization with a combination of both PiuA and PiaA resulted in additive protection and was highly protective against systemic infection with S. pneumoniae [PubMed: 11598041]." ;
    rdfs:label "PiaA" ;
    rdfs:seeAlso "Protegen ID: 623; NCBI Gene GI: 4442863; NCBI Protein GI: 116515816; NCBI Protein Accession: YP_815744; NCBITaxon: 373153" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011208
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A recombinant fowlpox virus expressing the fusion protein of Newcastle disease virus strain F48E8 protected chickens against virulent NDV challenge.  The protective rate was 96.7% [PubMed: 11191764]." ;
    rdfs:label "F fusion protein" ;
    rdfs:seeAlso "Protegen ID: 624; NCBI Gene GI: 912271; NCBI Protein GI: 11545723; NCBI Protein Accession: NP_071469; NCBITaxon: 11176" ;
    rdfs:subClassOf obo:VO_0010805, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011209
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant baculoviruses containing the fusion (F) and hemagglutinin-neuraminidase (HN) glycoprotein gene of the viscerotropic velogenic (vv) Newcastle disease virus (NDV) isolate, Kr-005/00, and a lentogenic La Sota strain of the NDV were constructed.  A single dose of rNDHN(V) had a protective effect against mortality (p <0.01) in chickens [PubMed: 18716451]." ;
    rdfs:label "HN hemagglutinin-neuraminidase" ;
    rdfs:seeAlso "Protegen ID: 625; NCBI Gene GI: 912270; NCBI Protein GI: 11545724; NCBI Protein Accession: NP_071470; NCBITaxon: 11176" ;
    rdfs:subClassOf obo:VO_0010805, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011210
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers constructed a new recombinant molecule of SERA5, namely SE36.  Vaccination of Squirrel monkeys with SE36 protein and aluminium hydroxyl gel (SE36/AHG) conferred protection against high parasitemia and boosted serum anti-SE36 IgG after P. falciparum parasite challenge [PubMed: 20493274]." ;
    rdfs:label "SERA-5" ;
    rdfs:seeAlso "Protegen ID: 626; NCBI Protein GI: 238629807; NCBITaxon: 5833" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011211
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination of mice with EAG (2-macroglobulin, albumin, and immunoglobulin G [IgG] binding protein) as a single antigen with EtxB (as an adjuvant) induced protection in mice against bacterial challenge, but was less protective than at affording protection than immunization with FNZ, SFS, EAG, and EtxB [PubMed: 15155624]." ;
    rdfs:label "binding protein Eag" ;
    rdfs:seeAlso "Protegen ID: 627; NCBI Gene GI: 7696154; NCBI Protein GI: 225870123; NCBI Protein Accession: YP_002746070; NCBITaxon: 553482" ;
    rdfs:subClassOf obo:VO_0010816, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011212
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers found that the cysteine-rich, carboxyl-terminal region of the MSP-1 protein from the rodent malarial parasite Plasmodium yoelii yoelii can be expressed in a native configuration as a fusion protein in Escherichia coli. This recombinant polypeptide elicits antibodies in mice which recognize the native parasite MSP-1. Most significantly, both inbred and outbred mice immunized with the fusion protein in Ribi adjuvant are partially and in some cases completely protected against challenge infection with an otherwise lethal parasite strain [PubMed: 8363656]." ;
    rdfs:label "MSP1 from P. yoelii str. 17XNL" ;
    rdfs:seeAlso "Protegen ID: 628; NCBI Gene GI: 3791597; NCBI Protein GI: 82596427; NCBI Protein Accession: XP_726257; NCBITaxon: 352914" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011213
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were immunised i.n. with collagen-binding protein (CNE) and were subsequently subjected to infection with S. equi subsp. equi. A control group of mice was given only adjuvant. The CNE vaccinated group had a delayed onset of infection compared to the control group. Immunization with CNE led to significant protection from infection [PubMed: 16580099]." ;
    rdfs:label "collagen binding, ancillary pilus subunit Cne" ;
    rdfs:seeAlso "Protegen ID: 629; NCBI Gene GI: 7695900; NCBI Protein GI: 225870316; NCBI Protein Accession: YP_002746263; NCBITaxon: 553482" ;
    rdfs:subClassOf obo:VO_0010816, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011214
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Parts of the three recombinant proteins (FNZ (cell surface-bound fibronectin binding protein), SFS (secreted fibronectin binding protein), and EAG (alpha2-macroglobulin, albumin, and immunoglobulin G [IgG] binding protein)) were used to immunize mice, either subcutaneously or intranasally, prior to nasal challenge with S. equi subsp. equi. The adjuvant used was EtxB, a recombinant form of the B subunit of Escherichia coli heat-labile enterotoxin. It was shown that nasal colonization of S. equi subsp. equi and weight loss due to infection were significantly reduced after vaccination compared with a mock-vaccinated control group. This effect was more pronounced after intranasal vaccination than after subcutaneous vaccination; nearly complete eradication of nasal colonization was obtained after intranasal vaccination (P < 0.001) [PubMed: 15155624]." ;
    rdfs:label "Fnz" ;
    rdfs:seeAlso "Protegen ID: 630; NCBI Gene GI: 7695217; NCBI Protein GI: 225869227; NCBI Protein Accession: YP_002745175; NCBITaxon: 40041" ;
    rdfs:subClassOf obo:VO_0010816, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011215
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Parts of the three recombinant proteins (FNZ (cell surface-bound fibronectin binding protein), SFS (secreted fibronectin binding protein), and EAG (alpha2-macroglobulin, albumin, and immunoglobulin G [IgG] binding protein)) were used to immunize mice, either subcutaneously or intranasally, prior to nasal challenge with S. equi subsp. equi. The adjuvant used was EtxB, a recombinant form of the B subunit of Escherichia coli heat-labile enterotoxin. It was shown that nasal colonization of S. equi subsp. equi and weight loss due to infection were significantly reduced after vaccination compared with a mock-vaccinated control group. This effect was more pronounced after intranasal vaccination than after subcutaneous vaccination; nearly complete eradication of nasal colonization was obtained after intranasal vaccination (P < 0.001) [PubMed: 15155624]." ;
    rdfs:label "Sfs" ;
    rdfs:seeAlso "Protegen ID: 631; NCBI Gene GI: 7696331; NCBI Protein GI: 225869898; NCBI Protein Accession: YP_002745845; NCBITaxon: 553482" ;
    rdfs:subClassOf obo:VO_0010816, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011216
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The fibrinogen-binding protein (FgBP) reacted with serum taken from horses recovering from strangles and protected mice against lethal challenge from S. equi subsp. equi [PubMed: 9579073]." ;
    rdfs:label "Fbp" ;
    rdfs:seeAlso "Protegen ID: 632; NCBI Gene GI: 7697172; NCBI Protein GI: 225871286; NCBI Protein Accession: YP_002747233; NCBITaxon: 553482" ;
    rdfs:subClassOf obo:VO_0010816, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011217
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers produced a prototypic malaria vaccine based on a highly versatile self-assembling polypeptide nanoparticle (SAPN) platform that can repetitively display antigenic epitopes. Researchers used this platform to display a tandem repeat of the B cell immunodominant repeat epitope (DPPPPNPN)(2)D of the malaria parasite Plasmodium berghei circumsporozoite (CS) protein. Administered in saline, without the need for a heterologous adjuvant, the SAPN construct P4c-Mal conferred a long-lived, protective immune response to mice with a broad range of genetically distinct immune backgrounds including the H-2(b), H-2(d), and H-2(k) alleles. Mice were protected against an initial challenge of parasites up to 6 mo after the last immunization or for up to 15 mo against a second challenge after an initial challenge of parasites had successfully been cleared.  [PubMed: 19915055]." ;
    rdfs:label "CS from P. berghei str. ANKA" ;
    rdfs:seeAlso "Protegen ID: 633; NCBI Gene GI: 3428738; NCBI Protein GI: 68076353; NCBI Protein Accession: XP_680096; NCBITaxon: 5823" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011218
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "CS from P. falciparum", "P. falciparum circumsporozoite protein" ;
    obo:IAO_0000119 "https://www.ncbi.nlm.nih.gov/pubmed/18159254" ;
    a owl:Class ;
    rdfs:comment "A P. berghei parasite line was used to expresses a heterologous circumsporozoite protein (CSP) from P. falciparum. A sterile immunity was obtained  by vaccination with the radiation-attenuated P. berghei parasite [PubMed: 18159254]." ;
    rdfs:label "P. falciparum CSP" ;
    rdfs:seeAlso "Protegen ID: 634; NCBI Protein GI: 552191; NCBITaxon: 5833" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011219
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study showed that immunization with irradiated sporozoites (IrrSpz) of a P. berghei line whose endogenous CS was replaced by that of P. yoelii conferred sterile protection against challenge with wild type P. berghei sporozoites [PubMed: 19890387]." ;
    rdfs:label "CS from P. yoelii str. 17XNL" ;
    rdfs:seeAlso "Protegen ID: 635; NCBI Gene GI: 3830374; NCBI Protein GI: 83317409; NCBI Protein Accession: XP_731149; NCBITaxon: 352914" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011220
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with a recombinant yeast-expressed Plasmodium falciparum merozoite surface protein 3 (MSP3) protected Aotus nancymai monkeys against a virulent challenge infection [PubMed: 19073223]." ;
    rdfs:label "MSP3" ;
    rdfs:seeAlso "Protegen ID: 636; NCBI Protein GI: 113207288; NCBITaxon: 5833" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011221
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with Plasmodium yoelii merozoite surface protein (PyMSP)-8 protects mice from lethal malaria but does not prevent infection [PubMed: 18097046]." ;
    rdfs:label "MSP8" ;
    rdfs:seeAlso "Protegen ID: 637; NCBI Protein GI: 58197887; NCBITaxon: 5861" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011222
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intranasal or oral delivery of the chimeric rotavirus VP6 protein MBP::VP6 to mice elicited >90% reductions in fecal rotavirus shedding after murine rotavirus challenge [PubMed: 17629371]." ;
    rdfs:label "VP6" ;
    rdfs:seeAlso "Protegen ID: 638; NCBI Protein GI: 268080815; NCBITaxon: 28327" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011223
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with r-Pfen (recombinant P. falciparum enolase protein) showed protection against a challenge with the 17XL lethal strain of the mouse malarial parasite Plasmodium yoelii [PubMed: 17785475]." ;
    rdfs:label "PF10_0155 enolase" ;
    rdfs:seeAlso "Protegen ID: 639; NCBI Gene GI: 810313; NCBI Protein GI: 124802328; NCBI Protein Accession: XP_001347440; NCBITaxon: 36329" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011224
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant PbAMA-1 were partially protected from the challenge of P. berghei [PubMed: 17639690]." ;
    rdfs:label "AMA-1 from P. berghei" ;
    rdfs:seeAlso "Protegen ID: 640; NCBI Protein GI: 1438889; NCBITaxon: 5821" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011225
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with recombinant rMSP1 (rPbMSP1), which was generated from Plasmodium berghei, in alum mounted significant protective immunity against challenge infection (P < 0.01). On day 121 after the booster, three out of ten mice immunized with rPbMSP1 in PBS survived parasite infection (P < 0.05) and eight out of ten mice vaccinated with r MSP1 in alum did (P < 0.01). Hence, immunization with MSP1 in alum obviously has conferred protective effects, which prevented death from P. berghei lethal infection in mice (P < 0.01) [PubMed: 17568385]." ;
    rdfs:label "MSP1 from P. berghei" ;
    rdfs:seeAlso "Protegen ID: 641; NCBI Protein GI: 1762646; NCBITaxon: 5821" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011226
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system.   Neonates of animals immunized with virus-like particles composed of VP7 assembled on VP6 spherical particles were protected against challenge with the homotypic virus and significantly protected from a heterotypic challenge.  Unassembled VP7 protein provided partial protection against challenge [PubMed: 8382422]." ;
    rdfs:label "VP7" ;
    rdfs:seeAlso "Protegen ID: 642; NCBI Protein GI: 195661008; NCBITaxon: 10927" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011227
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system.  Challenge of neonates born to animals immunized with VP4 protein on assembled particles or in cell lysates showed protection against challenge with both homologous (bovine C486) and heterologous (SA-11) strains of rotavirus [PubMed: 8382422]." ;
    rdfs:label "VP4" ;
    rdfs:seeAlso "Protegen ID: 643; NCBI Protein GI: 172054621; NCBITaxon: 10927" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011228
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization of mice with subunit vaccines based on the Plasmodium yoelii 17kDa hepatocyte erythrocyte protein (PyHEP17), orthologue of Plasmodium falciparum exported protein 1 (PfExp1), induces antigen-specific immune responses and protects against sporozoite challenge [PubMed: 17303242]." ;
    rdfs:label "HEP17" ;
    rdfs:seeAlso "Protegen ID: 644; NCBI Protein GI: 1399353; NCBITaxon: 5861" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011229
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunized animals were challenged in vivo with various parasite strains or clones of malaria. Immunization with the PfEMP1-DBL1 alpha domain abolished the PfEMP1-dependent sequestration of the homologous strain in immunized rats and substantially inhibited parasite adhesion in immunized monkeys. Protection against sequestration of heterologous parasite strains was also confirmed by direct or indirect challenge in the rat model [PubMed: 17074852]." ;
    rdfs:label "EMP1" ;
    rdfs:seeAlso "Protegen ID: 645; NCBI Protein GI: 2961468; NCBITaxon: 5833" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011230
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization of BALB/c mice and Aotus monkeys with PvMSP-1 induced IgG antibodies (titer > 10(6)) that cross-reacted with P. vivax parasites. Immunized monkeys displayed partial protection against a challenge with P. vivax blood stages [PubMed: 16291762]." ;
    rdfs:label "MSP1 from P. vivax" ;
    rdfs:seeAlso "Protegen ID: 646; NCBI Protein GI: 26985160; NCBITaxon: 5855" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011231
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A DNA vaccine based on lysosome-targeted glycoprotein of the rabies virus was evaluated in BALB/c mice. It imparted partial protection (60%) against challenge with 20 LD(50) of the challenge virus standard (CVS) strain of rabies virus [PubMed: 19741168]." ;
    rdfs:label "Glycoprotein" ;
    rdfs:seeAlso "Protegen ID: 647; NCBI Protein GI: 56384945; NCBITaxon: 11292" ;
    rdfs:subClassOf obo:VO_0010788, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011232
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated intraperitoneally (i.p.) with 10^7 p.f.u. of a vaccinia virus recombinant expressing either the glycoprotein (rVac-G) or nucleoprotein (rVac-N) of rabies virus 3 weeks before challenge were protected against peripheral lethal infection [PubMed: 8207400]." ;
    rdfs:label "RABVgp1 nucleoprotein N" ;
    rdfs:seeAlso "Protegen ID: 648; NCBI Gene GI: 1489853; NCBI Protein GI: 9627198; NCBI Protein Accession: NP_056793; NCBITaxon: 11292" ;
    rdfs:subClassOf obo:VO_0010788, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011233
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Two large fragments of PfKbeta representing the N- and C-terminal halves were expressed in E. coli. The recombinant proteins were highly immunogenic in mice, and also found to be the target for immune response in natural infections of Plasmodium spp.  Immunization with recombinant PfKbeta fragments was partially protective against a heterologous challenge infection in mice [PubMed: 15987343]." ;
    rdfs:label "Kbeta" ;
    rdfs:seeAlso "Protegen ID: 649; NCBI Gene GI: 813054; NCBI Protein GI: 124506397; NCBI Protein Accession: XP_001351796; NCBITaxon: 36329" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011234
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with one of the constructs of M. vaccae expressing OmpA in combination with booster immunization with the homologous recombinant protein protected a significant portion of mice from lethal challenge [PubMed: 11738766]." ;
    rdfs:label "OmpA" ;
    rdfs:seeAlso "Protegen ID: 650; NCBI Protein GI: 112710; NCBITaxon: 783" ;
    rdfs:subClassOf obo:VO_0010846, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011235
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "R. rickettsii OmpB contain B and T lymphocyte epitopes. Immunizations with each of two fragments from OmpB (rompB1550-2738 and rompB2459-4123) conferred protection against challenge with a lethal dose of R. conorii. Protection appeared to be better achieved among the groups that received both DNA and recombinant protein immunizations, although recombinant protein immunizations alone provided some protection [PubMed: 11693887]." ;
    rdfs:label "OmpB" ;
    rdfs:seeAlso "Protegen ID: 651; NCBI Protein GI: 6685726; NCBITaxon: 783" ;
    rdfs:subClassOf obo:VO_0010846, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011236
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection [PubMed: 15385527]." ;
    rdfs:label "MSP4/5" ;
    rdfs:seeAlso "Protegen ID: 652; NCBI Protein GI: 49798469; NCBITaxon: 73239" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011237
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with a refolded, recombinant, Plasmodium chabaudi AMA1 fragment (AMA1B) can withstand subsequent challenge with P. chabaudi adami [PubMed: 10861076]." ;
    rdfs:label "AMA-1 from P. chabaudi" ;
    rdfs:seeAlso "Protegen ID: 653; NCBI Protein GI: 1469500; NCBITaxon: 5825" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011238
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant adenovirus expressing gB (rAd-gB) was found to induce effective protective immunity against a virulent viral infection, regardless of whether it was administered via the muscular or systemic route [PubMed: 19116444]." ;
    rdfs:label "GB" ;
    rdfs:seeAlso "Protegen ID: 654; NCBI Protein GI: 4138504; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011239
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A trial vaccine containing pseudorabies virus (PRV) glycoprotein gC as the main component showed excellent protection against virulent virus infection in pigs [PubMed: 9300361]." ;
    rdfs:label "UL44" ;
    rdfs:seeAlso "Protegen ID: 655; NCBI Gene GI: 2952505; NCBI Protein GI: 51557513; NCBI Protein Accession: YP_068347; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011240
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The pseudorabies virus (PrV) DNA vaccine carrying the glycoprotein D (gD) gene delivered by E. coli was able to induce protective immune responses in mice against a lethal PrV challenge [PubMed: 11312026]. Immunization of mice with affinity-purified gD of Aujeszky's disease virus (ADV, Suid herpesvirus 1) induced a strong humoral immune response and protected mice against lethal ADV challenge [PubMed: 17601050]." ;
    rdfs:label "US6" ;
    rdfs:seeAlso "Protegen ID: 656; NCBI Gene GI: 2952521; NCBI Protein GI: 51557553; NCBI Protein Accession: YP_068387; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011241
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A monkey vaccination trial using a Plasmodium falciparum protein fraction containing antigens of 90-110 kDa is reported.   Three monkeys out of five resisted a heavy challenge dose of highly virulent parasites.  Hsp90 was found in the immunoprecipitates obtained with SERP antisera. Interestingly, the response to hsp90 correlated with protection, high antibody titres being found only in the protected monkeys [PubMed: 8303938]." ;
    rdfs:label "Hsp90" ;
    rdfs:seeAlso "Protegen ID: 657; NCBI Protein GI: 1093612; NCBITaxon: 5833" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011242
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To examine the response by IE180 more closely, a vaccine trial in mice with a vector DNA construct that contains the gene encoding for IE180, designated pcDNAIE180 was conducted.  Seven months after immunization with pcDNAIE180, an overall 25% of BALB/c, C3H/HeJ, and C57BL/6 mice receiving a lethal PrV challenge were protected [PubMed: 9586695]." ;
    rdfs:label "IE180" ;
    rdfs:seeAlso "Protegen ID: 658; NCBI Gene GI: 2952540; NCBI Protein GI: 51557548; NCBI Protein Accession: YP_068382; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011243
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "An open reading frame 2 plasmid (pORF2) and the capsid protein (Cap) of PCV2 were used as DNA and subunit vaccines, respectively. In FCM analysis, although pORF2 and Cap alone showed comparable efficacy in eliciting lymphoproliferative responses and Cap-specific CD4(+) T cells, pORF2 was superior to the Cap protein in triggering CD8(+) T cells. Following virus challenge, real-time PCR and histopathological analysis confirmed that only low viral DNA loads and mild microscopic lesions appeared in pORF2-immunized mice [PubMed: 18632956]." ;
    rdfs:label "ORF2" ;
    rdfs:seeAlso "Protegen ID: 659; NCBI Protein GI: 78217439; NCBITaxon: 85708" ;
    rdfs:subClassOf obo:VO_0010799, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011244
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To examine the mechanism of immunity in vivo, researchers used poliovirus receptor-transgenic mice on a BALB/c (H-2d) background.  Mice immunized with the vaccine strain were protected against a subsequent challenge with wild-type virus.  Protection was observed when mice received primed B cells in the presence of a VP4-specific Th1 clone.   Findings demonstrate that CD4+ T cells, specific for the internal poliovirus capsid protein, VP4, can provide effective help for a protective antibody response directed against surface capsid proteins [PubMed: 7699320]." ;
    rdfs:label "VP4" ;
    rdfs:seeAlso "Protegen ID: 660; NCBI Protein GI: 68532656; NCBITaxon: 12080" ;
    rdfs:subClassOf obo:VO_0010787, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011245
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Series of plasmid constructs encoding different forms of the envelope glycoprotein E of the flavivirus tick-borne encephalitis virus were constructed. These included a secreted recombinant subviral particle, a secreted carboxyl-terminally truncated soluble homodimer, a nonsecreted full-length form, and an inefficiently secreted truncated form. Mice were immunized using both i.m. injection and Gene Gun-mediated application of plasmids. The functional immune response was evaluated by determining specific neutralizing and hemagglutination-inhibiting Ab activities and by challenging the mice with a lethal dose of the virus.The plasmid construct encoding a secreted subviral particle, which carries multiple copies of the protective Ag on its surface, was superior to the other constructs in terms of extent and functionality of the Ab response as well as protection against virus challenge [PubMed: 10586074]." ;
    rdfs:label "TBEVgp1 polyprotein" ;
    rdfs:seeAlso "Protegen ID: 661; NCBI Gene GI: 1489719; NCBI Protein GI: 9628432; NCBI Protein Accession: NP_043135; NCBITaxon: 11084" ;
    rdfs:subClassOf obo:VO_0010793, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011246
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Monoclonal antibodies to gE  neutralize VZV in vitro in a complement- dependent manner [PubMed: 9125048]. Guinea pigs immunized with recombinant varicella-zoster virus (VZV) glycoproteins E (gE) and I (gI) developed antigen-specific antibodies in the sera, vitreous, and conjunctival washes. Sera from immunized animals neutralized both cell-free and cell-associated VZV, and peripheral blood lymphocytes proliferated in vitro in response to recombinant gE and gI and to antigens from VZV-infected cells. Immunized guinea pigs were inoculated intravitreally with VZV, which induces chronic uveitis. VZV DNA was more rapidly cleared and infectious VZV was isolated less frequently from the retinas of animals immunized with gE and gI compared with that in controls receiving adjuvant alone [PubMed: 9697709]." ;
    rdfs:label "ORF68" ;
    rdfs:seeAlso "Protegen ID: 662; NCBI Gene GI: 1487709; NCBI Protein GI: 9625942; NCBI Protein Accession: NP_040190; NCBITaxon: 10335" ;
    rdfs:subClassOf obo:VO_0010792, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011247
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Monoclonal antibodies to gI neutralize VZV in vitro in a complement- dependent manner [PubMed: 3021804]. Guinea pigs immunized with recombinant varicella-zoster virus (VZV) glycoproteins E (gE) and I (gI) developed antigen-specific antibodies in the sera, vitreous, and conjunctival washes. Sera from immunized animals neutralized both cell-free and cell-associated VZV, and peripheral blood lymphocytes proliferated in vitro in response to recombinant gE and gI and to antigens from VZV-infected cells. Immunized guinea pigs were inoculated intravitreally with VZV, which induces chronic uveitis. VZV DNA was more rapidly cleared and infectious VZV was isolated less frequently from the retinas of animals immunized with gE and gI compared with that in controls receiving adjuvant alone [PubMed: 9697709]." ;
    rdfs:label "ORF67" ;
    rdfs:seeAlso "Protegen ID: 663; NCBI Gene GI: 1487689; NCBI Protein GI: 9625941; NCBI Protein Accession: NP_040189; NCBITaxon: 10335" ;
    rdfs:subClassOf obo:VO_0010792, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011248
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A NYVAC vaccinia vector containing genes for pseudorables virus glycoproteins gII and gp50 was administered to pigs to determine if it would have a greater protective effect than a vector containing the gene for gp50 alone. Both NYVAC vectors protected pigs similarly from virulent pseudorabies virus challenge [PubMed: 8904669]." ;
    rdfs:label "Gp50" ;
    rdfs:seeAlso "Protegen ID: 664; NCBI Protein GI: 2440155; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011249
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A NYVAC vaccinia vector containing genes for pseudorables virus glycoproteins gII and gp50 was administered to pigs to determine if it would have a greater protective effect than a vector containing the gene for gp50 alone. Both NYVAC vectors protected pigs similarly from virulent pseudorabies virus challenge [PubMed: 8904669]." ;
    rdfs:label "GII" ;
    rdfs:seeAlso "Protegen ID: 665; NCBI Protein GI: 1335775; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011250
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with either gII, gIII, gVI antigen or a mixture of them were challenged intraperitoneally with 8.5 x 10(3) plaque forming units of PRV. All the mice immunized with 1.5 and 4.5 micrograms of the mixture and 4.5 micrograms of the gIII antigen survived [PubMed: 1322712]." ;
    rdfs:label "GIII" ;
    rdfs:seeAlso "Protegen ID: 667; NCBI Protein GI: 334050; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011251
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination of mice with fusion proteins containing the N terminus of gI from Suid herpesvirus 1 are able to confer protection to mice against a lethal challenge of PRV [PubMed: 1693164]." ;
    rdfs:label "GI" ;
    rdfs:seeAlso "Protegen ID: 668; NCBI Protein GI: 255957222; NCBITaxon: 10345" ;
    rdfs:subClassOf obo:VO_0010800, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011252
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A recombinant, vP869, expressing prM and E induced high titers of neutralizing and hemagglutination inhibiting antibodies in mice and was protective against intracranial challenge with the French neurotropic strain of YFV [PubMed: 1736531]." ;
    rdfs:label "E (envelope glycoprotein)" ;
    rdfs:seeAlso "Protegen ID: 669; NCBI Protein GI: 262283879; NCBITaxon: 11089" ;
    rdfs:subClassOf obo:VO_0010791, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011253
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Horses were vaccinated with adjuvanted recombinant SnSAG1 (rSnSAG1)and 5 control (sham vaccinated) horses were vaccinated with adjuvant only.  The effect of vaccination with rSnSAG1 on in vivo infection by S. neurona was evaluated by challenging all the horses with S. neurona merozoites. The study showed that vaccination with rSnSAG-1 produced antibodies in horses that neutralized merozoites when tested by in vitro culture and significantly reduced clinical signs demonstrated by in vivo challenge [PubMed: 19794889]." ;
    rdfs:label "SAG1" ;
    rdfs:seeAlso "Protegen ID: 672; NCBI Protein GI: 295682690; NCBITaxon: 42890" ;
    rdfs:subClassOf obo:VO_0010830, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011254
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Both inbred BALB/c and outbred CD-1 mice were immunized with rotavirus VP2/6-rVLPs (2/6-VLPs) combined with CT-E29H, orally or intranasally (i.n.), and the comparative efficacy of different formulations was then determined.  Two immunizations with 2-6VLPs and CT-E29H were sufficient to protect BALB/c mice, regardless of the route of administration [PubMed: 11270595]." ;
    rdfs:label "VP2" ;
    rdfs:seeAlso "Protegen ID: 673; NCBI Protein GI: 431460; NCBITaxon: 10970" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011255
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Plasmid DNA vaccines encoding for murine rotaviral proteins VP4, VP6, and VP7 were tested in adult BALB/c mice for their ability to induce immune responses and provide protection against rotavirus challenge.  Vaccines  encoding VP4 were effective in protecting mice against infection after rotavirus (100 ID50) challenge [PubMed: 9015117]." ;
    rdfs:label "VP4" ;
    rdfs:seeAlso "Protegen ID: 675; NCBI Protein GI: 475695; NCBITaxon: 28327" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011256
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Plasmid DNA vaccines encoding for murine rotaviral proteins VP4, VP6, and VP7 were tested in adult BALB/c mice for their ability to induce immune responses and provide protection against rotavirus challenge.  Vaccines  encoding VP7 were effective in protecting mice against infection after rotavirus (100 ID50) challenge [PubMed: 9015117]." ;
    rdfs:label "VP7" ;
    rdfs:seeAlso "Protegen ID: 676; NCBI Protein GI: 475697; NCBITaxon: 28327" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011257
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "VP6 derived from Group A rotavirus conferred in vivo partial protection against rotavirus challenge in a neonatal mouse model [PubMed: 18632867]." ;
    rdfs:label "VP6" ;
    rdfs:seeAlso "Protegen ID: 677; NCBI Gene GI: 7011372; NCBI Protein GI: 210136699; NCBI Protein Accession: YP_002302229; NCBITaxon: 28875" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011258
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Rotavirus structural proteins VP4, VP6 and VP7 from Bovine Rotavirus Strain C486 were cloned and expressed in a baculovirus expression system.  Challenge of neonates born to animals immunized with VP6 protein showed partial protection [PubMed: 8382422]." ;
    rdfs:label "VP6" ;
    rdfs:seeAlso "Protegen ID: 678; NCBI Protein GI: 195661002; NCBITaxon: 10927" ;
    rdfs:subClassOf obo:VO_0010789, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011259
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Protection from lethal viral infection has been achieved with passively administered monoclonal antibody specific for flavivirus glycoprotein NS1 [PubMed: 1736531]. Immunization of monkeys with yellow fever virus-specified nonstructural protein NS1 resulted in protection against fatal hepatitis as well as marked reduction in the magnitude of viremia after subcutaneous challenge with yellow fever virus [PubMed: 3783816]." ;
    rdfs:label "NS1 (non-structural protein 1)" ;
    rdfs:seeAlso "Protegen ID: 684; NCBITaxon: 11089" ;
    rdfs:subClassOf obo:VO_0010791, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011260
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge.  A truncated portion of the LACK antigen (LACKp24) was able to induce the highest protective effect compared to other constructs.  The DNA vaccine encoding LACK was able to induce partial protection in mice [PubMed: 18951941]." ;
    rdfs:label "LACK" ;
    rdfs:seeAlso "Protegen ID: 734; NCBI Nucleotide GI: 1276476; NCBI Protein GI: 1276477; NCBI Protein Accession: AAA97577.1; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011261
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study compared the handling of overlapping 24-mer peptides from HIV Nef either mixed or covalently linked in tandem in one protein.  With adjuvant, overlapping peptides were capable of protecting Balb/c mice against lethal viral challenge with 3 108 plaque forming units of vv-nef, whereas the intact protein was less protective [PubMed: 19193636]." ;
    rdfs:label "Nef" ;
    rdfs:seeAlso "Protegen ID: 707; NCBI Gene GI: 156110; NCBI Protein GI: 28872818; NCBI Protein Accession: NP_057857; NCBITaxon: 11676" ;
    rdfs:subClassOf obo:VO_0010767, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011262
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "HIV-1 DNA plasmids expressing Env, Gag and Tat, either alone or combined with the corresponding protein immunogens formulated in the MF59 adjuvant, resulted in protection against an experimental HIV-1 infection in C57Bl/6 mice [PubMed: 17707956]." ;
    rdfs:label "Tat" ;
    rdfs:seeAlso "Protegen ID: 711; NCBI Gene GI: 155871; NCBI Protein GI: 9629358; NCBI Protein Accession: NP_057853; NCBITaxon: 11676" ;
    rdfs:subClassOf obo:VO_0010767, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011263
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "HIV-1 DNA plasmids expressing Env, Gag and Tat, either alone or combined with the corresponding protein immunogens formulated in the MF59 adjuvant, resulted in protection against an experimental HIV-1 infection in C57Bl/6 mice [PubMed: 17707956]." ;
    rdfs:label "Gag from HIV 1" ;
    rdfs:seeAlso "Protegen ID: 713; NCBI Gene GI: 155030; NCBI Protein GI: 9629360; NCBI Protein Accession: NP_057850; NCBITaxon: 11676" ;
    rdfs:subClassOf obo:VO_0010767, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011264
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with Recombinant-derived nucleoprotein (rNP) from S. typhimurium expressing the cloned NP gene from A/NT/60/68 (Jones & Brownlee, 1985) were protected against a lethal challenge with Influenza A/Puerto Rico/8/34 (A/PR8) virus but showed considerable morbidity before recovery [PubMed: 2172156]." ;
    rdfs:label "NP from Influenza A virus (A/nt/60/1968(H3N2))" ;
    rdfs:seeAlso "Protegen ID: 718; NCBI Protein GI: 324704; NCBITaxon: 384505" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011265
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Since the E2 amino-terminal sequence for all VEE subtype viruses is conserved, we tested the protective capacity in mice of passively transferred mAb 1A2B-10 and found it to protect from both epizootic and enzootic VEE virus challenge. Since horses are an important natural host for VEE virus, pep1-19 was used to immunize horses and was found to be immunogenic and to elicit virus-reactive antibody [PubMed: 7543231]." ;
    rdfs:label "E2 envelope protein" ;
    rdfs:seeAlso "Protegen ID: 725; NCBI Protein GI: 25140296; NCBITaxon: 11036" ;
    rdfs:subClassOf obo:VO_0010774, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011266
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study demonstrated that a recombinant construction of heat-shock protein (hslU) with lypopolysaccharide (rcHSP-LPS) administered 24 hours before inoculation induced resistance to S. typhimurium infection. Protection formed after 3 injections of rcHSP-LPS with 10 mcg in each or single injection with 100 mcg/mouse. Forty to eighty percent of immunized mice survived after challenge while 90% of control animals died. Destruction of the HSP by boiling of the construction led to loss of protective effect [PubMed: 19621817]." ;
    rdfs:label "HslU" ;
    rdfs:seeAlso "Protegen ID: 726; NCBI Protein GI: 9650897; NCBITaxon: 90371" ;
    rdfs:subClassOf obo:VO_0010776, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011267
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The monoclonal antibody against E1 glycoprotein protect outbred albino mice from lethal infection caused by the virulent strain Trd of the VEE virus [PubMed: 7529989]." ;
    rdfs:label "E1 glycoprotein" ;
    rdfs:seeAlso "Protegen ID: 727; NCBI Protein GI: 798795; NCBITaxon: 11036" ;
    rdfs:subClassOf obo:VO_0010774, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011268
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunisation of mice with DnaJ derived from Salmonella enterica subsp. enterica serovar Typhi str. CT18 was found to provide 70% protection against lethal challenge by S. Typhimurium indicating the possible use of DnaJ as vaccine candidate against typhoid [PubMed: 16887241]." ;
    rdfs:label "DnaJ" ;
    rdfs:seeAlso "Protegen ID: 728; NCBI Gene GI: 1246524; NCBI Protein GI: 16759006; NCBI Protein Accession: NP_454623; NCBITaxon: 220341" ;
    rdfs:subClassOf obo:VO_0010776, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011269
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The viaB (tviB) gene coding for the Vi antigen of Salmonella typhi Ty2 was subcloned into expression vector pYA248. The recombinant plasmid was termed SMM202 and transformed into Salmonella typhimurium 4072, an attenuated crp mutant.  Immunization of mice with Vi4072 afforded complete protection against fatal infection with virulent S. typhi Ty2 [PubMed: 1612747]." ;
    rdfs:label "TviB" ;
    rdfs:seeAlso "Protegen ID: 729; NCBI Gene GI: 1067316; NCBI Protein GI: 29144603; NCBI Protein Accession: NP_807945; NCBITaxon: 209261" ;
    rdfs:subClassOf obo:VO_0010776, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011270
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The immune sera elicited by CTB DNA vaccine were functional and protective against V. cholerae O1 infection in mice [PubMed: 19443090]." ;
    rdfs:label "CtxB" ;
    rdfs:seeAlso "Protegen ID: 731; NCBI Protein GI: 110264635; NCBITaxon: 127906" ;
    rdfs:subClassOf obo:VO_0010848, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011271
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Antibodies against TCP were able to protect baby mice against challenge with V. cholerae O1 of the classical but not of the El Tor biotype [PubMed: 7911787]." ;
    rdfs:label "TcpA" ;
    rdfs:seeAlso "Protegen ID: 732; NCBI Protein GI: 21616882; NCBITaxon: 127906" ;
    rdfs:subClassOf obo:VO_0010848, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011272
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Antibodies generated against TcpF are protective against experimental V. cholerae infection in the infant mouse cholera model [PubMed: 16040956]." ;
    rdfs:label "TcpF" ;
    rdfs:seeAlso "Protegen ID: 733; NCBI Gene GI: 2614504; NCBI Protein GI: 15640854; NCBI Protein Accession: NP_230485; NCBITaxon: 243277" ;
    rdfs:subClassOf obo:VO_0010848, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011273
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge with L. major.  Mice inoculated pCMV3ISS-TSA developed significantly smaller lesions in their footpads after challenge with the parasite.  The vaccine was able to induce a partially protective effect [PubMed: 18951941]." ;
    rdfs:label "TSA" ;
    rdfs:seeAlso "Protegen ID: 735; NCBI Nucleotide GI: 3411093; NCBI Protein GI: 3411094; NCBI Protein Accession: AAC31146.1; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011274
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge with L. major. Mice inoculated pCMV3ISS-LmSTI1 developed significantly smaller lesions in their footpads after challenge with the parasite. The vaccine was able to induce a partially protective effect [PubMed: 18951941]." ;
    rdfs:label "LmSTI1" ;
    rdfs:seeAlso "Protegen ID: 736; NCBI Nucleotide GI: 1698879; NCBI Protein GI: 1698880; NCBI Protein Accession: AAB37318.1; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011275
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge with L. major.  Mice inoculated pCMV3ISS-CPa developed significantly smaller lesions in their footpads after challenge with the parasite.  The vaccine was able to induce a partially protective effect [PubMed: 18951941]." ;
    rdfs:label "Cpa" ;
    rdfs:seeAlso "Protegen ID: 737; NCBI Nucleotide GI: 71084305; NCBI Protein GI: 71084306; NCBI Protein Accession: AAZ23598.1; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011276
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The potential protection of Lmjsp (Leishmania major signal peptidase) was evaluated in three different vaccination strategies (DNA/DNA, Protein/Protein and DNA/Protein), against L. major infection. We demonstrated that vaccination with SPase through all three mentioned strategies induced a parasite specific Th1 response and conferred partial protection against parasite challenge. However, our results indicated that DNA/DNA strategy developed more effective protective responses than the other two approaches and induced 81% reduction in L. major parasite load [PubMed: 16481076]." ;
    rdfs:label "SP" ;
    rdfs:seeAlso "Protegen ID: 738; NCBI Protein GI: 23168331; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011277
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers tested the ability of the entire H2B protein of L. major, its divergent or conserved regions to provide protection against virulent L. major challenge.  The divergent amino-terminal region of H2B is able to confer potent protection against a virulent challenge in BALB/c mice [PubMed: 16417957]." ;
    rdfs:label "H2B" ;
    rdfs:seeAlso "Protegen ID: 739; NCBI Protein GI: 13384083; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011278
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Cell-mediated immunity to Leishmania major (L. major) was induced by injecting BALB/c mice intradermally with plasmid DNA expressing the conserved L. major cell surface glycoprotein gp63 (gp63-pcDNA-3).  Challenge studies revealed that gp63-pcDNA-3 vaccination protected 30% of susceptible mice (21 of 70) from Leishmania infection [PubMed: 9741428]." ;
    rdfs:label "Gp63" ;
    rdfs:seeAlso "Protegen ID: 741; NCBI Protein GI: 259011719; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011279
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intraperitoneal vaccination of C3H/He mice with PSA-2 with Corynebacterium parvum as an adjuvant resulted in complete protection from lesion development after challenge infection with virulent L. major. Significant protection was also obtained in the genetically susceptible BALB/cH-2k and BALB/c mice [PubMed: 7591056]." ;
    rdfs:label "PSA-2" ;
    rdfs:seeAlso "Protegen ID: 742; NCBI Protein GI: 1129058; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011280
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In a murine model of experimental cutaneous leishmaniasis, researchers investigated the protection elicited by injection of histone H1 (SW3.1) isolated from parasites by perchloric extraction, of a H1 recombinant protein produced in E. coli, and of H1 long and short synthetic peptides, against infection by L. major. Partial protection was achieved in most of the animals as shown by reduction in lesion size, upon immunization with histone H1 or its peptides, provided that the region 1-60 was present in the molecule [PubMed: 10580198]." ;
    rdfs:label "SW3.1" ;
    rdfs:seeAlso "Protegen ID: 743; NCBI Protein GI: 4008565; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011281
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Together with poloxamer 407 as adjuvant the recombinant type I (rCPB) cysteine proteinase of Leishmania major was screened as a potential vaccines against L. major in a mouse model.  Using the footpad thickness increase to monitor the clinical outcome/cutaneous lesion at site of L. major delivery, it was possible to document that rCPB allowed BALB/c mice to mount a partial protective response [PubMed: 12057598]." ;
    rdfs:label "Cpb" ;
    rdfs:seeAlso "Protegen ID: 744; NCBI Protein GI: 54287314; NCBITaxon: 5664" ;
    rdfs:subClassOf obo:VO_0010835, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011282
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Upon challenge with L. infantum, C57BL/6 mice immunized with SMT formulated in MPL-SE adjuvant showed significantly lower parasite burdens in both spleens and livers compared with non-immunized mice or mice injected with adjuvant alone [PubMed: 17804125]." ;
    rdfs:label "SMT" ;
    rdfs:seeAlso "Protegen ID: 745; NCBI Protein GI: 146104463; NCBITaxon: 435258" ;
    rdfs:subClassOf obo:VO_0010836, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011283
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study examined the immunogenic properties of the Leishmania infantum acidic ribosomal protein P0 (LiP0) in the BALB/c mouse model.  When mice were immunized with pcDNA3-LiP0, noticeable protection against L. major infection was achieved [PubMed: 14573678]." ;
    rdfs:label "LIPO-A" ;
    rdfs:seeAlso "Protegen ID: 746; NCBI Protein GI: 730579; NCBITaxon: 5671" ;
    rdfs:subClassOf obo:VO_0010836, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011284
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB/c mice immunized with a DNA vector expressing p36/LACK of Leishmania infantum followed by a booster with VVp36/LACK induced significant protection against Leishmania major infection [PubMed: 11489418]." ;
    rdfs:label "P36/LACK" ;
    rdfs:seeAlso "Protegen ID: 747; NCBI Protein GI: 134085114; NCBITaxon: 5671" ;
    rdfs:subClassOf obo:VO_0010836, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011285
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following infection with L. infantum promastigotes, five out of eight beagle dogs immunized with H1 Montanide remained free of clinical signs, compared to two out of eight dogs in the control group.  The results demonstrate that H1 antigens with Montanide were able to induce partial protection against canine leishmaniasis, even under extreme experimental challenge conditions [PubMed: 17576026]." ;
    rdfs:label "H1" ;
    rdfs:seeAlso "Protegen ID: 748; NCBI Nucleotide GI: 78146499; NCBI Protein GI: 78146500; NCBI Protein Accession: ABB22792.1; NCBITaxon: 5671" ;
    rdfs:subClassOf obo:VO_0010836, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011286
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following infection with L. infantum promastigotes, four out of eight beagle dogs immunized with HASPB1 Montanide remained free of clinical signs, compared to two out of eight dogs in the control group.  The results demonstrate that HASPB1 antigens with Montanide were able to induce partial protection against canine leishmaniasis, even under extreme experimental challenge conditions [PubMed: 17576026]." ;
    rdfs:label "HASPB1" ;
    rdfs:seeAlso "Protegen ID: 749; NCBI Nucleotide GI: 3724133; NCBI Protein GI: 3724134; NCBI Protein Accession: CAA09789.1; NCBITaxon: 5661" ;
    rdfs:subClassOf obo:VO_0010836, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011287
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In 1923, it was discovered that treatment with formalin eliminated the toxicity of diphtheria toxin (DT) without destroying its immunogenicity. Formalinreated DT, now called diphtheria toxoid, rapidly became the preferred vaccine against diphtheria, and diphtheria toxoid (usually in combined vaccines, such as diphtheriaetanus toxoidsertussis vaccine [DTP] or diphtheriaetanus toxoidscellular pertussis vaccine [DTaP] for children and tetanusiphtheria toxoids vaccine for adults [Td]) is still used throughout the world for active immunization against diphtheria [PubMed: 10657208]." ;
    rdfs:label "Tox" ;
    rdfs:seeAlso "Protegen ID: 750; NCBI Protein GI: 38199106; NCBITaxon: 1717" ;
    rdfs:subClassOf obo:VO_0010798, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011288
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Susceptible BALB/c mice were immunized with the DNA encoding P4 alone, P4/IL-12, or P4/HSP70 prior to challenge with L. amazonensis promastigotes.  Mice immunized with P4 alone had a delayed onset of lesion development and significantly smaller lesions than the infection control group at 11 weeks postinfection (P < 0.05).  P4/IL-12 immunized animals showed no sign of lesion development in three independent experiments (P < 0.01).  Our results indicate that different vaccine combinations, including DNA encoding P4, HSP70, or IL-12, can provide significant protection against both Old World and New World cutaneous leishmaniasis [PubMed: 14573646]." ;
    rdfs:label "P4" ;
    rdfs:seeAlso "Protegen ID: 751; NCBI Nucleotide GI: 29165286; NCBI Protein GI: 29165287; NCBI Protein Accession: AAO65599.1; NCBITaxon: 5659" ;
    rdfs:subClassOf obo:VO_0010837, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011289
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To examine the efficacy of a new mode of recombinant viral vaccine, a vaccine was constructed of two non-transmissible Sendai viruses (rSeV/dF) encoding the full-length parasite antigen amastigote surface protein-2 (ASP2) or ASP2 fused with a mono-ubiquitin on its N-terminus (UASP2). C57BL/6 mice immunized intranasally with rSeV/dF expressing either ASP2 or UASP2 showed significantly suppressed parasitemia and could be protected from lethal T. cruzi challenge [PubMed: 19712768]." ;
    rdfs:label "T. cruzi amastigote surface protein-2" ;
    rdfs:seeAlso "Protegen ID: 752; NCBI Protein GI: 284180153; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011290
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "DNA vaccination in BALB/c mice with the LAWD (for Leishmania antigenic WD protein) and IL-12 genes significantly delayed lesion development from challenge with Leishmania amazonensis, which correlated with a dramatic reduction in parasite burdens [PubMed: 15039343]." ;
    rdfs:label "WD" ;
    rdfs:seeAlso "Protegen ID: 753; NCBI Nucleotide GI: 38455440; NCBI Protein GI: 38455441; NCBI Protein Accession: AAR20840.1; NCBITaxon: 5659" ;
    rdfs:subClassOf obo:VO_0010837, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011291
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization of CBA mice with the M-2 glycoprotein of L. amazonensis and C. parvum adjuvant resulted in complete protection against a challenge infection of 10^4 and 10^6 late log-phase promastigotes of L. amazonensis. In the BALB/c strain, complete protection was observed in some of the immunized animals (28 to 50%); in the rest of the mice the onset of infection was significantly delayed. Protective immunity for C57BL/6 mice was observed only at the low infecting dose (10(4) L. amazonensis organisms) [PubMed: 3182080]." ;
    rdfs:label "M2" ;
    rdfs:seeAlso "Protegen ID: 754; NCBI Nucleotide GI: 2828562; NCBI Protein GI: 2828563; NCBI Protein Accession: AAC08302.1; NCBITaxon: 5659" ;
    rdfs:subClassOf obo:VO_0010837, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011292
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "cDNAs encoding L. m. amazonensis gp46 antigen were subcloned into the VR1012 plasmid, and susceptible BALB/c mice were immunised with two i.m. injections of 100 microg of plasmid DNA.  Mice were challenged by the injection of 4 x 10^6 L. m. mexicana parasites in the foot pad to evaluate protection. Measurement of lesion size indicated that mice immunised with VR012-GP46 were partially protected against infection [PubMed: 11713811]." ;
    rdfs:label "Gp46" ;
    rdfs:seeAlso "Protegen ID: 755; NCBI Nucleotide GI: 159320; NCBI Protein GI: 159321; NCBI Protein Accession: AAA29234.1; NCBITaxon: 5659" ;
    rdfs:subClassOf obo:VO_0010837, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011293
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To study the protective effects in vivo of cruzipain-specific Th1 responses against systemic T. cruzi challenges, mice  were immunized with recombinant cruzipain plus interleukin 12 (IL-12) and a neutralizing anti-IL-4 MAb. These immunized mice developed potent cruzipain-specific memory Th1 cell responses and were significantly protected against normally lethal systemic T. cruzi challenges. To study whether cruzipain could induce mucosal immune responses relevant for vaccine development, recombinant attenuated Salmonella enterica serovar Typhimurium vaccines expressing cruzipain were prepared. BALB/c mice immunized with salmonella expressing cruzipain were significantly protected against T. cruzi mucosal infection [PubMed: 12183554]." ;
    rdfs:label "T. cruzi Cruzipain" ;
    rdfs:seeAlso "Protegen ID: 756; NCBI Protein GI: 1136308; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011294
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "To develop a vaccine strategy taking advantage of activated CD8(+)T cells,a DNA vaccine, designated pGFP-TSA1, encoding a fusion protein linking GFP to a single CTL epitope of TSA1(TS), a leading candidate for vaccine against T. cruzi was constructed. C57BL/6 mice vaccinated with this plasmid showed suppressed parasitemia and prolonged survival. Vaccination with pGFP-TSA1 enhanced epitope-specific cytotoxicity and IFN-gamma secretion by CD8(+)T cells [PubMed: 18321749]." ;
    rdfs:label "T. cruzi TS" ;
    rdfs:seeAlso "Protegen ID: 757; NCBI Protein GI: 258547365; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011295
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A 500 bp fragment encoding an isoform of cysteine proteinase (CP) from Leishmania (Leishmania) amazonensis was subcloned and expressed in the pHis vector, resulting in a recombinant protein of 24 kDa, rLacys24.  Immunization of BALB/c mice with rLacys24 plus CFA adjuvant resulted in a low but significant decrease of foot lesions after challenge with L. (L.) amazonensis compared to those exhibited by control mice [PubMed: 19735658]." ;
    rdfs:label "CP cysteine proteinase" ;
    rdfs:seeAlso "Protegen ID: 758; NCBI Nucleotide GI: 30142041; NCBI Protein GI: 30142042; NCBI Protein Accession: AAN34826.1; NCBITaxon: 5659" ;
    rdfs:subClassOf obo:VO_0010837, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011296
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Following the intramuscular immunization of H-2(b) and H-2(d) mice with a plasmid DNA encoding an N-terminally truncated TSA-1 lacking or containing the C-terminal nonapeptide tandem repeats, the antibody level, CTL response, and protection against challenge with T. cruzi were assessed. In H-2(b) mice, antiparasite antibodies were induced only by immunization with the DNA construct encoding TSA-1 containing the C-terminal repeats. However, both DNA constructs were efficient in eliciting long-lasting CTL responses against the protective H-2Kb-restricted TSA-1515-522 epitope. In H-2(d) mice, inoculation with either of the two TSA-1-expressing vectors effectively generated antiparasite antibodies and primed CTLs that lysed T. cruzi-infected cells in an antigen-specific, MHC class I-restricted, and CD8(+)-T-cell-dependent manner. When TSA-1 DNA-vaccinated animals were challenged with T. cruzi, 14 of 22 (64%) H-2(b) and 16 of 18 (89%) H-2(d) mice survived the infection [PubMed: 9784506]." ;
    rdfs:label "T. cruzi TSA-1" ;
    rdfs:seeAlso "Protegen ID: 759; NCBI Protein GI: 162315; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011297
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A complement regulatory protein (CRP) of Trypanosoma cruzi was evaluated as a vaccine candidate in a murine model of experimental T. cruzi infection. Recombinant CRP derived from an Escherichia coli expression system and a plasmid encoding the full-length crp structural gene under the control of a eukaryotic promoter were used to immunize BALB/c mice. Immunization with both protein and DNA vaccines resulted in a Th1-type T-cell response, comparable antibody titers, and similar immunoglobulin G isotype profiles. Only mice immunized with the crp DNA plasmid produced antibodies capable of lysing the parasites in the presence of complement and were protected against a lethal challenge with T. cruzi trypomastigotes [PubMed: 10948115]." ;
    rdfs:label "T. cruzi CRP-10" ;
    rdfs:seeAlso "Protegen ID: 760; NCBI Protein GI: 1389837; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011298
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The vaccine efficacy of a  putative candidate antigen against T. cruzi infection and disease in a mouse model. C57BL/6 mice vaccinated with a T. cruzi G4-encoding plasmid and cytokine (interleukin-12 and granulocyte-macrophage colony-stimulating factor) expression plasmids elicited a strong Th1-type antibody response dominated by immunoglobulin G2b (IgG2b)/IgG1 isotypes. The dominant IgG2b/IgG1 antibody response was maintained after a challenge infection and was associated with 90% control of the acute-phase tissue parasite burden and an almost undetectable level of tissue parasites during the chronic phase, as determined by a sensitive T. cruzi 18S rRNA gene-specific real-time PCR approach [PubMed: 18550728]." ;
    rdfs:label "T. cruzi G4" ;
    rdfs:seeAlso "Protegen ID: 761; NCBI Protein GI: 52424038; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011299
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The vaccine efficacy of a putative candidate antigen against T. cruzi infection and disease in a mouse model. C57BL/6 mice vaccinated with a T. cruzi G2-encoding plasmid and cytokine (interleukin-12 and granulocyte-macrophage colony-stimulating factor) expression plasmids elicited a strong Th1-type antibody response dominated by immunoglobulin G2b (IgG2b)/IgG1 isotypes. The dominant IgG2b/IgG1 antibody response was maintained after a challenge infection and was associated with 50% control of the acute-phase tissue parasite burden and an almost undetectable level of tissue parasites during the chronic phase, as determined by a sensitive T. cruzi 18S rRNA gene-specific real-time PCR approach [PubMed: 18550728]." ;
    rdfs:label "T. cruzi G2" ;
    rdfs:seeAlso "Protegen ID: 762; NCBI Protein GI: 205278890; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011300
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Tc00.1047053434931.10" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice were immunized s.c. with recombinant PFR-2 (PAR2)  protein co-adsorbed to alum with rIL-12. rPFR-2 immunized animals were able to successfully resolve parasitemia by day 30 p.i., with the peak parasitemia occurring between days 17 and 21 p.i. [PubMed: 12798650]." ;
    rdfs:label "T. cruzi PAR2" ;
    rdfs:seeAlso "Protegen ID: 763; NCBI Gene GI: 3532027; NCBI Protein GI: 71398801; NCBI Protein Accession: XP_802646; NCBITaxon: 353153" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011301
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice were immunized s.c. with recombinant PFR-1 (PAR1) protein co-adsorbed to alum with rIL-12. rPFR-1 immunized animals were able to successfully resolve parasitemia by day 30 p.i., with the peak parasitemia occurring between days 17 and 21 p.i. [PubMed: 12798650]." ;
    rdfs:label "T. cruzi PAR1" ;
    rdfs:seeAlso "Protegen ID: 764; NCBI Protein GI: 2209137; NCBITaxon: 5693" ;
    rdfs:subClassOf obo:VO_0010838, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011302
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Skin and mucosal vaccination of ponies with HA from influenza virus A/equine/Ky/1/81 provided complete protection from clinical signs of infection after challenge, while skin vaccination provided partial protection; DNA vaccination provided partial protection from viral shedding [PubMed: 10403592]." ;
    rdfs:label "HA from Influenza A virus (A/equine/Kentucky/1/1981(H3N8))" ;
    rdfs:seeAlso "Protegen ID: 765; NCBI Nucleotide GI: 166079523; NCBI Protein GI: 166079524; NCBI Protein Accession: ABY81481.1; NCBITaxon: 475467" ;
    rdfs:subClassOf obo:VO_0010782, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011303
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Flagellin encoding plasmid DNA was injected into Balb/c mice intramuscularly and this elicited both a humoral and a cellular immune response. Subsequent intravenous challenge of the vaccinated Balb/c mice with 10^5CFU of B. pseudomallei resulted in the number of bacterial cells detected in liver and/or spleen being significantly reduced in the flagellin plasmid DNA vaccinated mice. At 7 days subsequent to infection of B. pseudomallei, 5/6 (83%) of flagellin plasmid DNA vaccinated mice had survived [PubMed: 16169637]." ;
    rdfs:label "FliC" ;
    rdfs:seeAlso "Protegen ID: 770; NCBI Protein GI: 1929918; NCBITaxon: 28450" ;
    rdfs:subClassOf obo:VO_0010840, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011304
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Transgenic rice immunization expressing the Chlamydophila psittaci (Cp. psittaci) antigen (MOMP) fused to the B subunit of Escherichia coli heat-labile enterotoxin (LTB) induced partial protection (53.3%) against a lethal challenge with the highly virulent Cp. psittaci 6BC strain in a BALB/c mouse model [PubMed: 19146896]." ;
    rdfs:label "MOMP from C. psittaci 6BC" ;
    rdfs:seeAlso "Protegen ID: 771; NCBI Nucleotide GI: 40568; NCBI Protein GI: 40569; NCBI Protein Accession: CAA40300.1; NCBITaxon: 331636" ;
    rdfs:subClassOf obo:VO_0010839, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011305
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "This report describes the successful cloning of the E2 gene of WEEV and expression in Escherichia coli as inclusion bodies.  The immunogenicity of the refolded rE2 protein was demonstrated by strong humoral and cell mediated immune (CMI) responses in rE2-immunized BALB/c mice. The current study also demonstrated that rE2-immunized mice could be partially protected from lethal challenge of WEEV [PubMed: 17499379]." ;
    rdfs:label "E2" ;
    rdfs:seeAlso "Protegen ID: 773; NCBI Protein GI: 29611992; NCBITaxon: 11039" ;
    rdfs:subClassOf obo:VO_0010841, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011306
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain [PubMed: 19923571].

Note:  The E1 glycoprotein is part of the 6K-E1 structural protein""" ;
    rdfs:label "E1" ;
    rdfs:seeAlso "Protegen ID: 774; NCBI Nucleotide GI: 17148716; NCBI Protein GI: 17148717; NCBI Protein Accession: AAL35792.1; NCBITaxon: 11039" ;
    rdfs:subClassOf obo:VO_0010841, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011307
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain [PubMed: 19923571].

Note:  The 6K protein is part of the 6K-E1 structural protein""" ;
    rdfs:label "6K" ;
    rdfs:seeAlso "Protegen ID: 775; NCBI Protein GI: 29611993; NCBITaxon: 11039" ;
    rdfs:subClassOf obo:VO_0010841, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011308
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In this study, Cp23 antigen was investigated as a vaccine candidate using the DNA vaccine model in adult interleukin-12 (IL-12) knockout (KO) mice, which are susceptible to C. parvum infection.  Cp23-DNA vaccination induced a 50-60% reduction in oocysts shedding, indicating a partial protection against C. parvum infection in IL-12 KO mice [PubMed: 17487508]." ;
    rdfs:label "CP23" ;
    rdfs:seeAlso "Protegen ID: 776; NCBI Protein GI: 88659549; NCBITaxon: 5807" ;
    rdfs:subClassOf obo:VO_0010842, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011309
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Preparturient cows were immunized three times over a six-week period with recombinant plasmid DNA encoding the Cryptosporidium parvum CP15/60 antigen by injecting the DNA in the mammary gland.  Colostrum from these cows contained Ab specific for C. parvum sporozoites and oocysts as indicated by immunofluorescence Ab (IFA) staining.  Mice receiving immune colostrum showed partial protection (about 50% reduction) against intestinal C. parvum development compared to mice receiving control colostrum. This protection was evident at a challenge dose of 10^3 C. parvum oocysts per mouse [PubMed: 10392628]." ;
    rdfs:label "CP15/60" ;
    rdfs:seeAlso "Protegen ID: 777; NCBI Nucleotide GI: 170676501; NCBI Protein GI: 170676502; NCBI Protein Accession: ACB30404.1; NCBITaxon: 5807" ;
    rdfs:subClassOf obo:VO_0010842, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011310
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A subunit vaccine formulation containing only recombinant, soluble, attachment glycoprotein G from HeV (sG(HeV)) and CpG adjuvant was evaluated as a potential NiV vaccine in the cat model.  Upon oronasal challenge with NiV (50,000TCID50), all vaccinated cats were protected from disease although virus was detected on day 21 post-challenge in one animal [PubMed: 18556094]." ;
    rdfs:label "G glycoprotein" ;
    rdfs:seeAlso "Protegen ID: 779; NCBI Gene GI: 1446471; NCBI Protein GI: 29468607; NCBI Protein Accession: NP_047112; NCBITaxon: 63330" ;
    rdfs:subClassOf obo:VO_0010843, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011311
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A recombinant baculovirus encoding a dengue (DEN)-2 virus envelope glycoprotein truncated of 102 amino acids (aa) at its C-terminus (D2EA102) was constructed. Both intracellular and extracellular D2EA102 induced neutralizing antibodies in mice and were thus immunogenic. Sixty eight percent (P < 0.001) of mice vaccinated with 5 gg of extracellular D2EA102 protein were protected against lethal challenge [PubMed: 7826210]." ;
    rdfs:label "E protein" ;
    rdfs:seeAlso "Protegen ID: 780; NCBI Protein GI: 202078796; NCBITaxon: 11060" ;
    rdfs:subClassOf obo:VO_0010844, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011312
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The protective efficacy and immune responses of mice intramuscularly injected with plasmid encoding DEN-2 non-structural protein 1 (NS1) was evaluated. Intravenously challenged by lethal DEN-2, mice vaccinated with NS1-DNA exhibited a delay onset of paralysis, a marked decrease of morbidity, and a significant enhancement of survival [PubMed: 12922127]." ;
    rdfs:label "NS1" ;
    rdfs:seeAlso "Protegen ID: 781; NCBI Protein GI: 288848; NCBITaxon: 11060" ;
    rdfs:subClassOf obo:VO_0010844, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011313
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Hamsters were immunized subcutaneously with either 107 PFU of VV-NiV.G or VV-NiV.F expressing the G and F glycoproteins, respectively, or with the two combined.  When the VV-NiV.G-vaccinated animals were challenged with Nipah virus 3 months after the last immunization (1,000 PFU/animal intraperitoneally), there was complete protection against mortality [PubMed: 14694115]." ;
    rdfs:label "G glycoprotein" ;
    rdfs:seeAlso "Protegen ID: 782; NCBI Gene GI: 920955; NCBI Protein GI: 13559814; NCBI Protein Accession: NP_112027; NCBITaxon: 121791" ;
    rdfs:subClassOf obo:VO_0010845, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011314
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Hamsters were immunized subcutaneously with either 10^7 PFU of VV-NiV.G or VV-NiV.F expressing the G and F glycoproteins, respectively, or with the two combined.  When the VV-NiV.F-vaccinated animals were challenged with Nipah virus 3 months after the last immunization (1,000 PFU/animal intraperitoneally), there was complete protection against mortality [PubMed: 14694115]." ;
    rdfs:label "F fusion protein" ;
    rdfs:seeAlso "Protegen ID: 783; NCBI Nucleotide GI: 8164021; NCBI Protein GI: 8164022; NCBI Protein Accession: AAF73956.1; NCBITaxon: 121791" ;
    rdfs:subClassOf obo:VO_0010845, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011315
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A recombinant vaccinia virus that expressed the pre-M protein of Dengue 4 virus was constructed. Mice immunized with the recombinant virus were protected against subsequent dengue 4 encephalitis challenge [PubMed: 1926792]." ;
    rdfs:label "PrM" ;
    rdfs:seeAlso "Protegen ID: 784; NCBI Protein GI: 18308086; NCBITaxon: 11070" ;
    rdfs:subClassOf obo:VO_0010844, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011316
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A recombinant vaccinia virus that expressed the M protein of Dengue 4 virus was constructed. Mice immunized with the recombinant virus were protected against subsequent dengue 4 encephalitis challenge [PubMed: 1926792]." ;
    rdfs:label "M protein" ;
    rdfs:seeAlso "Protegen ID: 785; NCBI Protein GI: 73671170; NCBITaxon: 11070" ;
    rdfs:subClassOf obo:VO_0010844, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011317
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Guinea pigs immunized with different doses of the SPA appear to be protected against challenge with live organisms as compared with nonimmunized controls [PubMed: 2122457]." ;
    rdfs:label "SpaP" ;
    rdfs:seeAlso "Protegen ID: 786; NCBI Protein GI: 152498; NCBITaxon: 782" ;
    rdfs:subClassOf obo:VO_0010846, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011318
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The glycoprotein (GP) and nucleocapsid (NC) genes of Rift Valley fever virus (RVFV) were expressed in different expression systems and were evaluated for their ability to protect mice from virulent challenge using a prime-boost regime.  Mice vaccinated with a lumpy skin disease virus-vectored recombinant vaccine (rLSDV-RVFV) expressing the two RVFV glycoproteins (G1 and G2, expressed by the RVFV M Segment) developed neutralising antibodies and were fully protected when challenged, as were those vaccinated with a crude extract of truncated G2 glycoprotein (tG2) [PubMed: 16870311]." ;
    rdfs:label "RVFVsMgp1 M protein" ;
    rdfs:seeAlso "Protegen ID: 787; NCBI Gene GI: 956559; NCBI Protein GI: 27881464; NCBI Protein Accession: NP_777376; NCBITaxon: 11588" ;
    rdfs:subClassOf obo:VO_0010849, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011319
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunisation of mice with cDNA encoding the nucleocapsid protein induced strong humoral and lymphocyte proliferative immune responses.  Even though complete protection was not achieved by genetic immunisation, four out of eight mice vaccinated with cDNA encoding the nucleocapsid protein displayed no clinical signs of infection after challenge. In contrast, all fourteen control animals displayed clinical manifestations of Rift Valley Fever after challenge [PubMed: 19149901]." ;
    rdfs:label "RVFVsSgp2 N protein" ;
    rdfs:seeAlso "Protegen ID: 788; NCBI Gene GI: 956562; NCBI Protein GI: 9632367; NCBI Protein Accession: NP_049344; NCBITaxon: 11588" ;
    rdfs:subClassOf obo:VO_0010849, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011320
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The receptor-binding domain (RBD) of SARS-CoV spike (S) protein is an important target in developing safe and effective SARS vaccines. A previous study has demonstrated that vaccination with adeno-associated virus encoding RBD (RBD-rAAV) induces high titer of neutralizing antibodies. The immune responses and protective effect of the immunization with RBD-rAAV prime/RBD-specific T cell peptide boost were assessed. Compared with the RBD-rAAV prime/boost vaccination, RBD-rAAV prime/RBD-peptide (RBD-Pep) boost induced similar levels of Th1 and neutralizing antibody responses that protected the vaccinated mice from subsequent SARS-CoV challenge, but stronger Th2 and CTL responses. No significant immune responses and protective effects were detected in mice vaccinated with RBD-Pep or blank AAV alone [PubMed: 18289745]." ;
    rdfs:label "S protein of SARS-CoV" ;
    rdfs:seeAlso "Protegen ID: 789; NCBI Gene GI: 1489668; NCBI Protein GI: 29836496; NCBI Protein Accession: NP_828851; NCBITaxon: 694009" ;
    rdfs:subClassOf obo:VO_0010850, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011321
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice actively immunized using a recombinant V antigen (rVagHis, encoded by lcrV gene) of Y. enterocolitica were completely protected against challenge with both, Y. enterocolitica 0:8 and Y. pseudotuberculosis serotype III [PubMed: 10089162]." ;
    rdfs:label "LcrV" ;
    rdfs:seeAlso "Protegen ID: 790; NCBI Gene GI: 1449458; NCBI Protein GI: 32470278; NCBI Protein Accession: NP_863514; NCBITaxon: 630" ;
    rdfs:subClassOf obo:VO_0010851, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011322
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "80% of C3H/HeJ mice immunized with Eh29 administered in combination with a subclinical dose of whole cholera toxin, but not as an Eh29-CTxB fusion, showed no evidence of infection in tissue sections harvested following intracecal challenge with virulent E. histolytica trophozoites. These results suggest that Eh29 is capable of inducing protective anti-amoebic immune responses in mice following oral immunization and could be used in the development of oral vaccines against amoebiasis [PubMed: 20303954]." ;
    rdfs:label "GEh29" ;
    rdfs:seeAlso "Protegen ID: 791; NCBI Nucleotide GI: 399673; NCBI Protein GI: 399674; NCBI Protein Accession: CAA50324.1; NCBITaxon: 5759" ;
    rdfs:subClassOf obo:VO_0010852, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011323
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Study tested if vaccination with the E. histolytica Gal/GalNAc lectin could prevent cecal infection in a C3H mouse model of amebic colitis. Vaccination prevented intestinal infection with efficacies of 84 and 100% in the two native lectin trials and 91 and 34% in the two LecA trials.  Results show for the first time that immunization with the Gal/GalNAc lectin can prevent intestinal amebiasis in mice [PubMed: 14741152]." ;
    rdfs:label "Gal/GalNAc lectin" ;
    rdfs:seeAlso "Protegen ID: 792; NCBI Gene GI: 3404842; NCBI Protein GI: 67469085; NCBI Protein Accession: XP_650534; NCBITaxon: 294381" ;
    rdfs:subClassOf obo:VO_0010852, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011324
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Report describes a recombinant fusion protein containing the serine-rich Entamoeba histolytica protein (SREHP), a protective antigen derived from virulent amebae, and a bacterially derived maltose-binding protein (MBP) from an attenuated strain of Salmonella typhimurium.  Gerbils vaccinated with S typhimurium SREHP-MBP were protected against amebic liver abscess after challenge with E. histolytica, the most common extraintestinal complication of amebiasis [PubMed: 8613356]." ;
    rdfs:label "SREHP" ;
    rdfs:seeAlso "Protegen ID: 793; NCBI Gene GI: 3402462; NCBI Protein GI: 67463194; NCBI Protein Accession: XP_648254; NCBITaxon: 294381" ;
    rdfs:subClassOf obo:VO_0010852, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011325
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Groups of C57BL/6 mice (20 per group) vaccinated with rPep1 (1 mug per dose) plus adjuvant and challenged with an intranasal inoculum began to die at about 14 to 16 days but then showed significantly greater survival than the control mice [PubMed: 16369008]." ;
    rdfs:label "PEP1" ;
    rdfs:seeAlso "Protegen ID: 794; NCBI Protein GI: 73915320; NCBITaxon: 199306" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011326
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researcherse tested the ability of the galactose-specific adherence lectin of E. histolytica to elicit a protective immune response in conjunction with Freund's incomplete and complete adjuvants.  Four independent trials demonstrated complete protection from amebic liver abscess formation in 67% of lectin-immunized gerbils.  The gerbil antilectin antibodies were shown by Western immunoblotting to be directed to the heavy subunit (CEL-170/4) but not the light subunit of the lectin [PubMed: 1987067]." ;
    rdfs:label "CEL-170/4" ;
    rdfs:seeAlso "Protegen ID: 795; NCBI Protein GI: 401088; NCBITaxon: 5759" ;
    rdfs:subClassOf obo:VO_0010852, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011327
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice immunized with rPlb showed a significant reduction of the fungal burden in their lungs at 90 days postchallenge compared to the control mice at 15 days [PubMed: 16369008]." ;
    rdfs:label "PLB" ;
    rdfs:seeAlso "Protegen ID: 796; NCBI Protein GI: 74486661; NCBITaxon: 199306" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011328
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "C57BL/6 mice immunized with rAMN1 showed a significant reduction of the fungal burden in their lungs at 90 days postchallenge compared to the control mice at 15 days [PubMed: 16369008]." ;
    rdfs:label "AMN1" ;
    rdfs:seeAlso "Protegen ID: 797; NCBI Protein GI: 76786276; NCBITaxon: 199306" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011329
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "ELI-Antigen 1 (ELI-Ag1) was tested for its protective capacity in BALB/c mice against intraperitoneal challenge with 2500 arthroconidia of this dimorphic fungus and was found to be highly protective [PubMed: 14505918]." ;
    rdfs:label "ELI-Ag1" ;
    rdfs:seeAlso "Protegen ID: 798; NCBI Protein GI: 37779128; NCBITaxon: 5501" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011330
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The GEL1 mRNA of C. posadasii was detected at the highest level during the endosporulation stage of the parasitic cycle, and the mature protein was immunolocalized to the surface of endospores. BALB/c or C57BL/6 mice were immunized subcutaneously with the bacterium-expressed recombinant protein (rGel1p) to evaluate its protective efficacy against a lethal challenge of C. posadasii by either the intraperitoneal or intranasal route. In both cases, rGel1p-immune mice infected with the pathogen showed a significant reduction in fungal burden and increased survival compared to nonimmune mice [PubMed: 12761077]." ;
    rdfs:label "GEL1" ;
    rdfs:seeAlso "Protegen ID: 799; NCBI Protein GI: 14582416; NCBITaxon: 199306" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011331
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant urease (rURE) of C. immitis was expressed in Escherichia coli and tested asa vaccine candidate in BALB/c mice. BALB/c mice immunized subcutaneously with rURE and subsequently challenged by the intraperitoneal (i.p.) route with a lethal inoculum of C. immitis arthroconidia demonstrated a significant reduction in the level of C. immitis infection compared to control animals [PubMed: 11292702]." ;
    rdfs:label "URE" ;
    rdfs:seeAlso "Protegen ID: 800; NCBI Protein GI: 73808050; NCBITaxon: 5501" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011332
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant Pmp1 was reactive with serum from individuals with both acute and protracted disease, and evoked protection in two murine models of infection with C. posadasii [PubMed: 16495561]." ;
    rdfs:label "Pmp1" ;
    rdfs:seeAlso "Protegen ID: 801; NCBI Protein GI: 78364922; NCBITaxon: 199306" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011333
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "C57BL6 mice were immunized with syngeneic, bone marrow-derived DCs (JAWS II cells) transfected with a cDNA encoding the protective Coccidioides-Ag2/proline-rich Ag (pra). The immunized mice were lethally challenged with C. posadasii through either an i.p. or intranasal route. Upon necropsy after 10 days of infection, fungal burden in lung and spleen of immunized mice was significantly reduced as compared with the control animals. The lung tissue homogenates of immunized animals showed higher levels of IFN-gamma. Histologically, lung tissues of immunized mice were in better condition than the control mice [PubMed: 16148136]." ;
    rdfs:label "Pra" ;
    rdfs:seeAlso "Protegen ID: 802; NCBI Protein GI: 42742528; NCBITaxon: 5501" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011334
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The microtubule-associate protein (MAP p15) was tested as a vaccine in mice, and tests showed that p15 (native or recombinant) generated up to 100% protection from an otherwise lethal challenge of a heterologous strain of Trypanosoma brucei [PubMed: 15161078]." ;
    rdfs:label "MAPP15" ;
    rdfs:seeAlso "Protegen ID: 803; NCBI Protein GI: 777767; NCBITaxon: 5691" ;
    rdfs:subClassOf obo:VO_0010854, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011335
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination with poliovirus vector containing the gene for the B subunit of H. pylori urease provides significant prophylactic and strong therapeutic protection against H. pylori in mice [PubMed: 15603891]." ;
    rdfs:label "UreB" ;
    rdfs:seeAlso "Protegen ID: 804; NCBI Protein GI: 40737733; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011336
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Researchers  prepared an oral liposome-encapsulated recombinant Helicobacter pylori (Hp) heat shock protein 60 (Hsp60) vaccine and investigate its effect against Hp infection in mice.  rHsp60 plus CT (choleratoxin), liposome-encapsulated rHsp60 and liposome-encapsulated rHsp60 plus CT had protective rates against Hp infection of 73.3%, 66.7% and 86.7%, respectively [PubMed: 15897126]." ;
    rdfs:label "Hsp60" ;
    rdfs:seeAlso "Protegen ID: 805; NCBI Protein GI: 397869; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011337
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A study shows that vaccination of mice with HP-NAP (H. pylori NAP) induces protection against H. pylori challenge, and that the majority of infected patients produce antibodies specific for HP-NAP, suggesting an important role of this factor in immunity [PubMed: 10790422]." ;
    rdfs:label "NAP" ;
    rdfs:seeAlso "Protegen ID: 806; NCBI Protein GI: 8777456; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011338
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "BALB-c mice immunized intramuscularly with a single dose (100 microg) of a plasmid DNA encoding the 5'-terminal region of the trans-sialidase (nTSA) gene of T. brucei brucei are able to produce IgG antibodies that bind to the bloodstream form of T. brucei-protein extract and recognize the recombinant nTSA protein, expressed in Escherichia coli. Furthermore, this DNA vaccination process was able to protect 60% of mice submitted to a challenge assay with the infective form of T. brucei brucei parasites [PubMed: 19582478]." ;
    rdfs:label "TSA" ;
    rdfs:seeAlso "Protegen ID: 807; NCBI Protein GI: 62175539; NCBITaxon: 5691" ;
    rdfs:subClassOf obo:VO_0010854, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011339
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant H. pylori catalase plus CT was used for immunization, and groups of mice were challenged with the Sydney strain of H. pylori. Immunization with recombinant catalase protected a significant proportion (9 of 10) of the mice from H. pylori challenge, indicating that this enzyme should be considered as a candidate for a future vaccine [PubMed: 9353048]." ;
    rdfs:label "Catalase" ;
    rdfs:seeAlso "Protegen ID: 808; NCBI Protein GI: 3128145; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011340
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A study  to examine the immunostimulatory properties of Leishmania infantum Hsp83 (83) to elicit humoral and cellular response against the Toxoplasma gondii Rop2 protein in an adjuvant-free vaccination system was conducted. Mice immunized with fusion Rop2-83 elicited a stronger humoral and cellular response in comparison to mice immunized with Rop2 alone, or a mix of LiHsp83 and Rop2. The fusion protein induced a Th1 type response, with predominance of specific IgG2a/IgG2c isotype and IFN-gamma secretions, whereas Rop2 alone or mixed with LiHsp83 produced a Th1/Th2 mixed response. Vaccination with fusion protein conferred a remarkable resistance against oral infection with ME49 cysts in C57BL/6 and C3H mice, in comparison to mice immunized with Rop2 alone or the protein mixture. Following lethal challenge, a significant survival rate was observed in Rop2-83 immunized Balb/c and C57BL/6 mice in comparison to control groups [PubMed: 16545504]." ;
    rdfs:label "Rop2" ;
    rdfs:seeAlso "Protegen ID: 809; NCBI Protein GI: 115299638; NCBITaxon: 5811" ;
    rdfs:subClassOf obo:VO_0010826, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011341
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Treatment of the Helicobacter pylori vacuolating cytotoxin with very low concentrations of formaldehyde resulted in abrogation of toxic activity in both a HeLa cell vacuolation assay and an in vivo assay of gastric epithelial damage. Detoxification had only a minimal effect on the integrity of the oligomeric or monomeric structure. The toxoid retained the ability to bind to target cells and to induce high-titer neutralizing antibodies after immunization of rabbits. Furthermore, oral immunization of mice with the toxoid resulted in protection against infective challenge with mouse-adapted strains of H. pylori [PubMed: 9353041]." ;
    rdfs:label "VacA" ;
    rdfs:seeAlso "Protegen ID: 810; NCBI Protein GI: 50313203; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011342
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The immunogenicity of a 48-kDa T-cell-reactive protein (TCRP) was investigated. Immunization of BALB/c and C3H/HeN mice with the rTCRP affords a modest but significant level of protection against an intraperitoneal challenge with C. immitis. It is suggested that the rTCRP may be able to contribute to a multicomponent vaccine designed to stimulate CMI response against the parasitic cycle of C. immitis." ;
    rdfs:label "TcrP" ;
    rdfs:seeAlso "Protegen ID: 811; NCBI Protein GI: 13508695; NCBITaxon: 5501" ;
    rdfs:subClassOf obo:VO_0010853, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011343
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Some of the S. sciureus monkeys immunized with MSP-3(212-380)-AS02 or GLURP(27-500)-alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens [PubMed: 15049780]." ;
    rdfs:label "GLURP" ;
    rdfs:seeAlso "Protegen ID: 812; NCBI Gene GI: 810501; NCBI Protein GI: 124802897; NCBI Protein Accession: XP_001347628; NCBITaxon: 36329" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011344
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Asian seabass vaccinated with the OMP38 (OmpU) DNA vaccine was challenged with pathogenic V. anguillarum by intramuscular injection. A relative percent survival (RPS) rate of 55.6% was recorded [PubMed: 17337208]." ;
    rdfs:label "OmpU" ;
    rdfs:seeAlso "Protegen ID: 813; NCBI Protein GI: 26513901; NCBITaxon: 55601" ;
    rdfs:subClassOf obo:VO_0010815, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0011345
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus DNA vaccine encoding PrM" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1067" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011146
    ] .

obo:VO_0011346
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "DeltaFTT0918" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 439" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0011347
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "rLm/iglC" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 440" ;
    rdfs:subClassOf obo:VO_0000152 .

obo:VO_0011348
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "5CVMB" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 438" ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0011349
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. amazonensis DNA vaccine encoding WD protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1041" ;
    rdfs:subClassOf obo:VO_0012158, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011290
    ] .

obo:VO_0011350
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. infantum H1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1042" ;
    rdfs:subClassOf obo:VO_0012159, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011285
    ] .

obo:VO_0011351
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. infantum HASPB1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1043" ;
    rdfs:subClassOf obo:VO_0012159, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011286
    ] .

obo:VO_0011352
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus DNA vaccine pUJENS5" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1036" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011149
    ] .

obo:VO_0011353
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus DNA vaccine encoding E protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1037" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011146
    ] .

obo:VO_0011354
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. amazonensis DNA vaccine encoding GP46" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1038" ;
    rdfs:subClassOf obo:VO_0012158, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011292
    ] .

obo:VO_0011355
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. amazonensis M2 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1039" ;
    rdfs:subClassOf obo:VO_0012158, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011291
    ] .

obo:VO_0011356
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "A. pleuropneumoniae ApxIA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 782" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011019
    ] .

obo:VO_0011357
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pertussis Cpn60 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 797" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011035
    ] .

obo:VO_0011359
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pertussis CyaA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 799" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011031
    ] .

obo:VO_0011360
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "V. cholerae CTB DNA Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 800" ;
    rdfs:subClassOf obo:VO_0000763, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011270
    ] .

obo:VO_0011361
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pertussis PTx protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 801" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011039
    ] .

obo:VO_0011362
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. parvum DNA vaccine encoding CP23" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1050" ;
    rdfs:subClassOf obo:VO_0012160 .

obo:VO_0011363
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer Her-2/neu protein subunit vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1051" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011364
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer DNA vaccine encoding hNIS protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1052" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011365
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer DNA vaccine encoding Survivin" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1053" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011366
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer subunit NY-ESO-1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1047" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011367
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer DNA vaccine encoding endoglin boosted with recombinant endoglin protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1048" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011368
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer DNA vaccine encoding H-2Kb" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1049" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011369
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer DNA vaccine encoding TEM8" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1046" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011370
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer EPCAM protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1064" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011371
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer VEGFA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1066" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011372
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer Retroviral vector vaccine encoding Cd40lg" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1058" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011373
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer DNA vaccine encoding Cd86" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1059" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011374
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Phleum pratense Allergy Phl p 12 Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1054" ;
    rdfs:subClassOf obo:VO_0001362, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011280
    ] .

obo:VO_0011375
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. bovis GST-12D3" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 791" ;
    rdfs:subClassOf obo:VO_0000925, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000527 ;
        owl:someValuesFrom obo:VO_0011027
    ] .

obo:VO_0011377
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pertussis BrkA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 796" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011036
    ] .

obo:VO_0011378
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine leukemia virus DNA vaccine encoding Env" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 825" ;
    rdfs:subClassOf obo:VO_0012161, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011051
    ] .

obo:VO_0011379
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine leukemia virus DNA vaccine encoding Tax" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 828" ;
    rdfs:subClassOf obo:VO_0012161, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011050
    ] .

obo:VO_0011380
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. abortus DNA vaccine encoding RplL and Omp16" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 831" ;
    rdfs:subClassOf obo:VO_0001225, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010908
    ] .

obo:VO_0011381
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 DNA vaccine AdCMVgD" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 821" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011041
    ] .

obo:VO_0011382
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 DNA vaccine AdCMVgC" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 823" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011043
    ] .

obo:VO_0011383
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 GPI protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 824" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011042
    ] .

obo:VO_0011384
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "A. pleuropneumoniae ApxIa and ApxIIa protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 784" ;
    rdfs:subClassOf obo:VO_0001130, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011020
    ] .

obo:VO_0011385
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "A. pleuropneumoniae HS93C-Ampr" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 786" ;
    rdfs:subClassOf obo:VO_0001130 .

obo:VO_0011386
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "A. salmonicida live-attenuated vaccine encoding AroA" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 788" ;
    rdfs:subClassOf obo:VO_0000820, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011024
    ] .

obo:VO_0011387
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "NP-VRP" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 443" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010859
    ] .

obo:VO_0011388
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rickettsia rickettsii vaccine using M. vaccae expressing R. rickettsii OmpA Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1044" ;
    rdfs:subClassOf obo:VO_0000767, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011234
    ] .

obo:VO_0011389
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rickettsia DNA Vaccine encoding OmpB Protein boosted with Recombinant OmpB" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1045" ;
    rdfs:subClassOf obo:VO_0000767, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011235
    ] .

obo:VO_0011391
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pertussis DNA vaccine encoding Prn" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 808" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011033
    ] .

obo:VO_0011392
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Virus Vaccine rFPV/gI" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 993" ;
    rdfs:subClassOf obo:VO_0012162, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011165
    ] .

obo:VO_0011393
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Marek's Disease Virus Vaccine rFPV/gB1" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 994" ;
    rdfs:subClassOf obo:VO_0012162, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011164
    ] .

obo:VO_0011394
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Marburg Virus Nucleoprotein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 997" ;
    rdfs:subClassOf obo:VO_0012163, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011163
    ] .

obo:VO_0011395
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus E7 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 986" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011105
    ] .

obo:VO_0011396
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "P. falciparum Hsp90 Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 987" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011241
    ] .

obo:VO_0011397
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus L2 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 988" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011106
    ] .

obo:VO_0011398
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "IHNV DNA vaccine pIHNw-G" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 989" ;
    rdfs:subClassOf obo:VO_0012165, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011109
    ] .

obo:VO_0011399
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rift Valley Fever Virus DNA Vaccine encoding N Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 990" ;
    rdfs:subClassOf obo:VO_0012166, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011319
    ] .

obo:VO_0011400
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Puumala virus PUUVsSgp1 (NP) protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 949" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011088
    ] .

obo:VO_0011401
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Sin Nombre virus DNA vaccine encoding G1" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 950" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011086
    ] .

obo:VO_0011402
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Seoul virus vaccine rCAV-2-Gc" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 951" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011085
    ] .

obo:VO_0011403
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Topografov virus N protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 952" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011089
    ] .

obo:VO_0011404
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hepatitis B virus DNA vaccine pVAX-PS" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 968" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011094
    ] .

obo:VO_0011405
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 2 DNA vaccine encoding ICP27" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 969" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011100
    ] .

obo:VO_0011406
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 2 DNA vaccine encoding GB" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 970" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011097
    ] .

obo:VO_0011407
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "NIpah Virus G and F Proteins Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 971" ;
    rdfs:subClassOf obo:VO_0012169, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011314
    ] .

obo:VO_0011408
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 1 DNA vaccine encoding GC" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 972" ;
    rdfs:subClassOf obo:VO_0000958, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011103
    ] .

obo:VO_0011409
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hendra virus G protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 963" ;
    rdfs:subClassOf obo:VO_0012170, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011310
    ] .

obo:VO_0011410
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA Vaccine encoding Ag85B Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 964" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011172
    ] .

obo:VO_0011411
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Hepatitis B virus DNA vaccine encoding HBVgp2 pre-S1/pre-S2/S" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 965" ;
    rdfs:subClassOf obo:VO_0000644, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011095
    ] .

obo:VO_0011412
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis Mtb72F protein subunit vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 967" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011173
    ] .

obo:VO_0011413
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pertussis DNA vaccine encoding TcfA" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 813" ;
    rdfs:subClassOf obo:VO_0000765 .

obo:VO_0011414
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. histolytica CEL-170/4 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 918" ;
    rdfs:subClassOf obo:VO_0012171, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011326
    ] .

obo:VO_0011415
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "P. falciparum Subunit SE36 Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 919" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011210
    ] .

obo:VO_0011416
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. histolytica SREHP protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 920" ;
    rdfs:subClassOf obo:VO_0012171, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011324
    ] .

obo:VO_0011417
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. coli C3389 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 921" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010991
    ] .

obo:VO_0011418
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "P. falciparum Pfen Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 922" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011223
    ] .

obo:VO_0011419
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Mumps HN Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 973" ;
    rdfs:subClassOf obo:VO_0000656, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011171
    ] .

obo:VO_0011420
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 2 vaccine using phage displaying GG protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 974" ;
    rdfs:subClassOf obo:VO_0012168, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011102
    ] .

obo:VO_0011421
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 1 DNA vaccine encoding GD" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 975" ;
    rdfs:subClassOf obo:VO_0000958, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011098
    ] .

obo:VO_0011422
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Measles Virus vaccine VEE/SIN-H+F" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 976" ;
    rdfs:subClassOf obo:VO_0000654 .

obo:VO_0011423
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 1 DNA vaccine encoding GE" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 977" ;
    rdfs:subClassOf obo:VO_0000958, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011104
    ] .

obo:VO_0011424
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. pneumoniae DNA vaccine encoding PknD" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 887" ;
    rdfs:subClassOf obo:VO_0012173, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010894
    ] .

obo:VO_0011425
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. pneumoniae DNA vaccine encoding Ssb" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 888" ;
    rdfs:subClassOf obo:VO_0012173, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010896
    ] .

obo:VO_0011426
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. psittaci DNA vaccine pcDNA1/MOMP" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 889" ;
    rdfs:subClassOf obo:VO_0012174, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010924
    ] .

obo:VO_0011427
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Classical swine fever virus vaccine VAC-E0" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 890" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010898
    ] .

obo:VO_0011428
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding GatC" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 878" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011057
    ] .

obo:VO_0011429
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding OmlA" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 879" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011060
    ] .

obo:VO_0011430
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding MOMP" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 880" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010881
    ] .

obo:VO_0011431
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine Pomp90A" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 881" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011058
    ] .

obo:VO_0011432
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. pneumoniae CopN protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 882" ;
    rdfs:subClassOf obo:VO_0012173, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010884
    ] .

obo:VO_0011433
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "prostate cancer DNA vaccine encoding prostatic acid phosphatase (PAP)" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 883" ;
    rdfs:subClassOf obo:VO_0000177, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0000519
    ] .

obo:VO_0011434
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. pneumoniae DNA vaccine encoding FabD" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 884" ;
    rdfs:subClassOf obo:VO_0012173, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010895
    ] .

obo:VO_0011435
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. pneumoniae LcrE protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 885" ;
    rdfs:subClassOf obo:VO_0012173, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010883
    ] .

obo:VO_0011436
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pseudomallei Subunit LolC Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 860" ;
    rdfs:subClassOf obo:VO_0012175, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010921
    ] .

obo:VO_0011437
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum RplF protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 861" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010892
    ] .

obo:VO_0011438
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pseudomallei Subunit PotF Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 862" ;
    rdfs:subClassOf obo:VO_0012175, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010922
    ] .

obo:VO_0011439
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "P. yoelii MSP1 and MSP4/5 Proteins Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 984" ;
    rdfs:subClassOf obo:VO_0002514, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011236
    ] .

obo:VO_0011440
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "P. falciparum MSP3 Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 985" ;
    rdfs:subClassOf obo:VO_0000087, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011220
    ] .

obo:VO_0011441
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Lassa Virus Nucleoprotein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1035" ;
    rdfs:subClassOf obo:VO_0012177, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:VO_0011151
                [
                    a owl:Restriction ;
                    owl:onProperty obo:RO_0000087 ;
                    owl:someValuesFrom obo:VO_0000457
                ]
            )
        ]
    ] .

obo:VO_0011442
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. coli C4424 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 923" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010990
    ] .

obo:VO_0011443
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. coli Hma protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 924" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010984
    ] .

obo:VO_0011444
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. coli IreA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 925" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010985
    ] .

obo:VO_0011445
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. coli IutA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 926" ;
    rdfs:subClassOf obo:VO_0000628, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010986
    ] .

obo:VO_0011446
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "F. tularensis GroEL protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 928" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011075
    ] .

obo:VO_0011447
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "F. tularensis DNA vaccine rLm/iglC" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 929" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011072
    ] .

obo:VO_0011448
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. tenella vaccine rBCG pMV361-Rho" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 912" ;
    rdfs:subClassOf obo:VO_0001137, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011064
    ] .

obo:VO_0011449
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. tenella DNA vaccine pcDNA-TA4-IL-2" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 913" ;
    rdfs:subClassOf obo:VO_0001137, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011065
    ] .

obo:VO_0011450
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. histolytica Eh29 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 915" ;
    rdfs:subClassOf obo:VO_0012171, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011322
    ] .

obo:VO_0011451
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. histolytica Gal/GalNAc lectin protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 916" ;
    rdfs:subClassOf obo:VO_0012171, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011323
    ] .

obo:VO_0011452
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Dengue Vaccine using Vaccinia Virus expressing prM Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 853" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011315
    ] .

obo:VO_0011453
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum MOMP protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 854" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010890
    ] .

obo:VO_0011454
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Dengue DNA Vaccine encoding NS1 Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 855" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011312
    ] .

obo:VO_0011455
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Dengue Vaccine using Vaccinia Virus expressing M Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 856" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011316
    ] .

obo:VO_0011456
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum PmpE/F-2 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 857" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010893
    ] .

obo:VO_0011457
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Dengue Subunit E Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 858" ;
    rdfs:subClassOf obo:VO_0000725, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011311
    ] .

obo:VO_0011458
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum PmpG-1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 859" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010891
    ] .

obo:VO_0011459
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Canine distemper virus DNA vaccine encoding HA" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 847" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011052
    ] .

obo:VO_0011460
    obo:IAO_0000115 "a Coccidioides vaccine that contains C. posadasii PMP1 protein" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. posadasii subunit PMP1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 848" ;
    rdfs:subClassOf obo:VO_0012179, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011332
    ] .

obo:VO_0011461
    obo:IAO_0000115 "a Coccidioides vaccine that contains C. posadasii DNA vaccine encoding PRA protein" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. posadasii DNA Vaccine encoding PRA protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 849" ;
    rdfs:subClassOf obo:VO_0012179, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011333
    ] .

obo:VO_0011462
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Canine parvovirus DNA vaccine pGT36VP1" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 850" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011055
    ] .

obo:VO_0011463
    obo:IAO_0000115 "a Coccidioides vaccine that contains C. immitis subunit URE protein" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. immitis subunit URE protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 851" ;
    rdfs:subClassOf obo:VO_0012179, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011331
    ] .

obo:VO_0011464
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Canine parvovirus CPMV-PARVO1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 852" ;
    rdfs:subClassOf obo:VO_0012180, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011054
    ] .

obo:VO_0011465
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Ebola virus DNA vaccine encoding ZEBOV GP and SEBOV GP" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 901" ;
    rdfs:subClassOf obo:VO_0000726, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010910
    ] .

obo:VO_0011466
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "S. flexneri  Invaplex 24 Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 902" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010994
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010995
    ] .

obo:VO_0011467
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. maxima Gam82 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 903" ;
    rdfs:subClassOf obo:VO_0001125, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0000527 ;
        owl:someValuesFrom obo:VO_0011062
    ] .

obo:VO_0011468
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "S. flexneri Invaplex 50 Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 904" ;
    rdfs:subClassOf obo:VO_0000680, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010994
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010995
    ] .

obo:VO_0011469
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. tenella DNA vaccine proIE" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 905" ;
    rdfs:subClassOf obo:VO_0001137, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011066
    ] .

obo:VO_0011470
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. tenella GX3262 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 907" ;
    rdfs:subClassOf obo:VO_0001137, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011067
    ] .

obo:VO_0011471
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. tenella DNA vaccine EtMIC2" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 909" ;
    rdfs:subClassOf obo:VO_0001137, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011063
    ] .

obo:VO_0011472
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "E. tenella DNA vaccine rBCG pMV261-Rho" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 910" ;
    rdfs:subClassOf obo:VO_0001137, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011064
    ] .

obo:VO_0011473
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Vaxxitek HVT+IBD" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 397" ;
    rdfs:subClassOf obo:VO_0012162 .

obo:VO_0011474
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Newcastle disease virus vaccine by Dow AgroSciences" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 398" ;
    rdfs:subClassOf obo:VO_0001222 .

obo:VO_0011475
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Theileria parva vaccine by Centre for Ticks and Tickborne Disease, Malawi" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 427" ;
    rdfs:subClassOf obo:VO_0001061 .

obo:VO_0011476
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Theileria annulata vaccine by Local veterinary institutes" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 428" ;
    rdfs:subClassOf obo:VO_0000909 .

obo:VO_0011477
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "H. pylori DNA vaccine encoding UreB" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 960" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011335
    ] .

obo:VO_0011478
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "M. tuberculosis DNA Vaccine APADNA priming and APAMVA boosting" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 961" ;
    rdfs:subClassOf obo:VO_0000077, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011175
    ] .

obo:VO_0011479
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "H. pylori VacA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 962" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011341
    ] .

obo:VO_0011480
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Human papillomavirus DNA vaccine pNGVL4a-E6/opt" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 981" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011107
    ] .

obo:VO_0011481
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "PCV2 DNA Vaccine encoding ORF2 Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 982" ;
    rdfs:subClassOf obo:VO_0001524, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011243
    ] .

obo:VO_0011482
    obo:IAO_0000115 "A multivalent vaccine against tetanus, diphtheria, and poliomyelitis." ;
    obo:IAO_0000117 "YH, ZX, NF" ;
    obo:IAO_0000118 "Tetanus and Diphtheria Toxoids Adsorbed and Inactivated Poliomyelitis Vaccine" ;
    obo:IAO_0000119 "WEB: https://www.vaccineshoppecanada.com/document.cfm?file=td_polio_adsorbed_e.pdf" ;
    a owl:Class ;
    rdfs:label "Td Polio Adsorbed" ;
    rdfs:seeAlso "ATC Code: J07CA01", "VIOLIN Vaccine ID: 630; VIOLIN Vaccine ID: 629; VIOLIN Vaccine ID: 628" ;
    rdfs:subClassOf obo:VO_0000586, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1513
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1717
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom [
            a owl:Class ;
            owl:intersectionOf (obo:NCBITaxon_12080
                obo:NCBITaxon_12083
                obo:NCBITaxon_12086
            )
        ]
    ] .

obo:VO_0011483
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "This term is obsolete since there is another term with the same name." ;
    rdfs:label "OBSOLETE - Td Polio Adsorbed" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 629" ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0011484
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "This term is obsolete since there is another term with the same name." ;
    rdfs:label "OBSOLETE - Td Polio Adsorbed" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 628" ;
    rdfs:subClassOf obo:VO_0000597 .

obo:VO_0011485
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. jejuni FspA1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 841" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011047
    ] .

obo:VO_0011486
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "SARS Subunit Spike Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 842" ;
    rdfs:subClassOf obo:VO_0012183, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011320
    ] .

obo:VO_0011487
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. jejuni FspA2 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 843" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011049
    ] .

obo:VO_0011488
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. jejuni DNA vaccine pcDNA3.1(+)-peblA" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 844" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011045
    ] .

obo:VO_0011489
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Canine distemper virus DNA vaccine encoding F and HA" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 845" ;
    rdfs:subClassOf obo:VO_0012178, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011053
    ] .

obo:VO_0011490
    obo:IAO_0000115 "a Coccidioides vaccine that contains C. posadasii subunit GEL1 protein" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. posadasii subunit GEL1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 846" ;
    rdfs:subClassOf obo:VO_0012179, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011330
    ] .

obo:VO_0011491
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "T. brucei DNA Vaccine encoding TSA protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 836" ;
    rdfs:subClassOf obo:VO_0012184, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011338
    ] .

obo:VO_0011492
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "T. brucei Subunit p15 Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 837" ;
    rdfs:subClassOf obo:VO_0012184, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011334
    ] .

obo:VO_0011493
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. jejuni MBP-FlaA protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 838" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011046
    ] .

obo:VO_0011494
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "T. parva Subunit p67 Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 839" ;
    rdfs:subClassOf obo:VO_0001061, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011183
    ] .

obo:VO_0011495
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. jejuni FlaC protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 840" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011048
    ] .

obo:VO_0011498
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pertussis FhaB and 69 kDa OMP protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 805" ;
    rdfs:subClassOf obo:VO_0000765, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011030
    ] .

obo:VO_0011499
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "H. influenzae Hap protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 936" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010916
    ] .

obo:VO_0011500
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus DNA vaccine encoding NS1 (pUSK-NS1)" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1033" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011147
    ] .

obo:VO_0011501
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus DNA vaccine pUJENS3" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1034" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011148
    ] .

obo:VO_0011502
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. parvum DNA vaccine encoding CP15/60" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 900" ;
    rdfs:subClassOf obo:VO_0012160, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011309
    ] .

obo:VO_0011503
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Y. enterocolititica Subunit V Antigen Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 896" ;
    rdfs:subClassOf obo:VO_0012186, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011321
    ] .

obo:VO_0011504
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. botulinum FHc protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 897" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010901
    ] .

obo:VO_0011505
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "WEEV DNA Vaccine encoding 6K-E1 Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 898" ;
    rdfs:subClassOf obo:VO_0012188, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011306
    ] .

obo:VO_0011506
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "WEEV Subunit E2 Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 899" ;
    rdfs:subClassOf obo:VO_0012188, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011305
    ] .

obo:VO_0011507
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer subunit GV1001 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 891" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011508
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Classical swine fever virus vaccine VAC-E2" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 892" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010897
    ] .

obo:VO_0011509
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Classical swine fever virus E1 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 893" ;
    rdfs:subClassOf obo:VO_0001012, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010899
    ] .

obo:VO_0011510
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "cancer subunit  DC (Tat-CEA) vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 894" ;
    rdfs:subClassOf obo:VO_0000177 .

obo:VO_0011511
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. botulinum DNA vaccine pSCARSBHc" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 895" ;
    rdfs:subClassOf obo:VO_0012187, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010904
    ] .

obo:VO_0011512
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Dobrava-Belgrade virus S nucleocapsid protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 954" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010960
    ] .

obo:VO_0011513
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "H. pylori catalase protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 955" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011339
    ] .

obo:VO_0011514
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "H. pylori NAP protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 958" ;
    rdfs:subClassOf obo:VO_0012181, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011337
    ] .

obo:VO_0011515
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "M. gallisepticum TM-1 Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 959" ;
    rdfs:subClassOf obo:VO_0000949, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011178
    ] .

obo:VO_0011516
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Japanese encephalitis virus vaccine BV-G-E" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1027" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011145
    ] .

obo:VO_0011517
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "T. annulata Subunit SPAG-1 Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 873" ;
    rdfs:subClassOf obo:VO_0000909, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011187
    ] .

obo:VO_0011518
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding DnaK" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 874" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010882
    ] .

obo:VO_0011519
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding DnaX" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 875" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011056
    ] .

obo:VO_0011520
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding GatA/GatB" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 876" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010879
    ] .

obo:VO_0011521
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "T. gondii Subunit Rop2-Hsp83 Fusion Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 866" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011340
    ] .

obo:VO_0011522
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum DNA vaccine encoding TC0757" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 867" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010886
    ] .

obo:VO_0011523
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA vaccine pcDNA3-MIC3" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 868" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011174
    ] .

obo:VO_0011524
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum DNA vaccine encoding TC0767/768" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 869" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010888
    ] .

obo:VO_0011525
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "T. gondii DNA Vaccine encoding SAG1 Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 870" ;
    rdfs:subClassOf obo:VO_0000994, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011000
    ] .

obo:VO_0011526
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding CAB049" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 871" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011059
    ] .

obo:VO_0011527
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. abortus DNA vaccine encoding CAB613" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 872" ;
    rdfs:subClassOf obo:VO_0001085, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011061
    ] .

obo:VO_0011528
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Infleunza virus DNA vaccine encoding NP from Influenza A virus (A/chicken/Henan/12/2004(H5N1))" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1023" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0011529
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding NP from Influenza A virus (A/chicken/Hubei/489/2004(H5N1))" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1024" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0011530
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000119 "http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=1025" ;
    a owl:Class ;
    rdfs:label "L. donovani DNA vaccine encoding KMP-11" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1025" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011157
    ] .

obo:VO_0011531
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Influenza virus NP protein vaccine (Influenza A virus (A/nt/60/1968(H3N2)))" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1026" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0011532
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. donovani gp63 Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1022" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011158
    ] .

obo:VO_0011533
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum DNA vaccine encoding TC0439" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 864" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010887
    ] .

obo:VO_0011534
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. muridarum DNA vaccine encoding TC0512" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 865" ;
    rdfs:subClassOf obo:VO_0012176, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0010885
    ] .

obo:VO_0011535
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Measles Virus Vaccine VVN" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 978" ;
    rdfs:subClassOf obo:VO_0000654 .

obo:VO_0011536
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Measles Virus Vaccine VVP" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 979" ;
    rdfs:subClassOf obo:VO_0000654 .

obo:VO_0011537
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Measles Virus Vaccine VVM" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 980" ;
    rdfs:subClassOf obo:VO_0000654 .

obo:VO_0011538
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "B. pseudomallei DNA vaccine encoding Flagellin Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 863" ;
    rdfs:subClassOf obo:VO_0012175, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011303
    ] .

obo:VO_0011539
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. donovani ORFF Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1017" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011159
    ] .

obo:VO_0011540
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding NA from Influenza B virus (B/Ibaraki/2/85)" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1018" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0011541
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Influenza virus DNA vaccine encoding NA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1019" ;
    rdfs:subClassOf obo:VO_0000642 .

obo:VO_0011542
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "L. donovani DNA Vaccine encoding NH36 Protein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 1020" ;
    rdfs:subClassOf obo:VO_0001142, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011161
    ] .

obo:VO_0011543
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Sin Nombre virus DNA vaccine encoding SNVsSgp1 (NP)" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 945" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011087
    ] .

obo:VO_0011544
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "S. equi Subunit EAG, FNZ and SFS Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 832" ;
    rdfs:subClassOf obo:VO_0000948, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011211
    ] .

obo:VO_0011545
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "C. jejuni DNA vaccine pcDNA3.1(+)-cadF" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 833" ;
    rdfs:subClassOf obo:VO_0012182, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011044
    ] .

obo:VO_0011546
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "S. equi Subunit CNE Protein Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 834" ;
    rdfs:subClassOf obo:VO_0000948, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011213
    ] .

obo:VO_0011548
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "F. tularensis DNA vaccine pTUL4-15" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 930" ;
    rdfs:subClassOf obo:VO_0000152, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011076
    ] .

obo:VO_0011549
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "P. berghei CS protein subunit vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 931" ;
    rdfs:subClassOf obo:VO_0002513, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011217
    ] .

obo:VO_0011550
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "G. duodenalis DNA vaccine encoding CWP2" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 932" ;
    rdfs:subClassOf obo:VO_0001083, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011080
    ] .

obo:VO_0011551
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "H. influenzae D15 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 933" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011083
    ] .

obo:VO_0011552
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Newcastle Disease Virus HN Glycoprotein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 934" ;
    rdfs:subClassOf obo:VO_0001222, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011209
    ] .

obo:VO_0011553
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rabies DNA Vaccine encoding Rabies virus Glycoprotein" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 816" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011231
    ] .

obo:VO_0011554
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 DNA vaccine tgD-VP22" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 817" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011040
    ] .

obo:VO_0011555
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Rabies vaccine rVac-N" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 818" ;
    rdfs:subClassOf obo:VO_0000650, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011232
    ] .

obo:VO_0011556
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Vivotif L" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 645" ;
    rdfs:subClassOf obo:VO_0000768 .

obo:VO_0011557
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Bovine herpesvirus 1 DNA vaccine pRSV-gC" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 815" ;
    rdfs:subClassOf obo:VO_0001482, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011043
    ] .

obo:VO_0011558
    obo:IAO_0000117 "Kallan Roan, Oliver He, OT, ZX" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/845529", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm179132.htm"^^xsd:anyURI ;
    obo:VO_0003099 "IXIARO"^^xsd:anyURI ;
    obo:VO_0003158 "Japanese Encephalitis Vaccine, Inactivated, Adsorbed"^^xsd:anyURI ;
    obo:VO_0003159 "Valneva Austria GmbH"^^xsd:anyURI ;
    obo:VO_0003160 "For the prevention of disease caused by Japanese encephalitis virus in persons 2 months of age and older."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142569.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125280"^^xsd:anyURI ;
    obo:VO_0003198 845529 ;
    a owl:Class ;
    rdfs:label "Ixiaro" ;
    rdfs:seeAlso "CVX: 134", "VIOLIN Vaccine ID: 741" ;
    rdfs:subClassOf obo:VO_0000665, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000127
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003949
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000086 ;
        owl:someValuesFrom obo:VO_0000211
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000864
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0003076 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0011559
    obo:IAO_0000117 "Kallan Roan, Oliver He, ZX" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/661026", "https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm186957.htm"^^xsd:anyURI ;
    obo:VO_0003099 "Cervarix"^^xsd:anyURI ;
    obo:VO_0003158 "Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant"^^xsd:anyURI ;
    obo:VO_0003159 "GlaxoSmithKline Biologicals"^^xsd:anyURI ;
    obo:VO_0003160 "Prevention of cervical cancer, cervical intraepithelial neoplasia (CIN) grade 2 or worse and adenocarcinoma in situ, and cervical intraepithelial neoplasia (CIN) grade 1, caused by oncogenic human papillomavirus (HPV) types 16 and 18, in females9 through 25 years of age."^^xsd:anyURI ;
    obo:VO_0003161 "https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf"^^xsd:anyURI ;
    obo:VO_0003162 "BL 125259"^^xsd:anyURI ;
    obo:VO_0003198 661026 ;
    a owl:Class ;
    rdfs:label "Cervarix" ;
    rdfs:seeAlso "CVX: 118", "VIOLIN Vaccine ID: 740" ;
    rdfs:subClassOf obo:VO_0000667, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003940
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003941
    ], [
        a owl:Restriction ;
        owl:onProperty obo:OBI_0000295 ;
        owl:someValuesFrom obo:VO_0001187
    ], [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000812
    ], [
        a owl:Restriction ;
        owl:onProperty obo:VO_0001243 ;
        owl:someValuesFrom obo:NCBITaxon_9606
    ], [
        a owl:Restriction ;
        owl:hasValue obo:VO_0000690 ;
        owl:onProperty obo:OBI_0000304
    ] .

obo:VO_0011561
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Andes virus vaccine using adenovirus viral vector expressing ANDV NP" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 943" ;
    rdfs:subClassOf obo:VO_0012167, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0002292 ;
        owl:someValuesFrom obo:VO_0011092
    ] .

obo:VO_0011562
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "H. influenzae Omp26 protein vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 938" ;
    rdfs:subClassOf obo:VO_0012185, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0010918
    ] .

obo:VO_0011563
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "N. caninum NcMIC1 Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 939" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011200
    ] .

obo:VO_0011564
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "N. caninum NcMAG1 Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 941" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011189
    ] .

obo:VO_0011565
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "N. caninum NcDG2 Protein Subunit Vaccine" ;
    rdfs:seeAlso "VIOLIN Vaccine ID: 942" ;
    rdfs:subClassOf obo:VO_0001065, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0011205
    ] .

obo:VO_0012158
    obo:IAO_0000115 "A vaccine that protects against Leishmania amazonensis." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Leishmania amazonensis" ;
    a owl:Class ;
    rdfs:label "Leishmania amazonensis vaccine" ;
    rdfs:subClassOf obo:VO_0000762 ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5659
    ] .

obo:VO_0012159
    obo:IAO_0000115 "A vaccine that protects against Leishmania infantum." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Leishmania infantum" ;
    a owl:Class ;
    rdfs:label "Leishmania infantum vaccine" ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000762
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_5671
            ]
        )
    ] .

obo:VO_0012160
    obo:IAO_0000115 "A vaccine that protects against Cryptosporidium parvum." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Cryptosporidium parvum" ;
    a owl:Class ;
    rdfs:label "Cryptosporidium parvum vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5807
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5807
    ] .

obo:VO_0012161
    obo:IAO_0000115 "A vaccine that protects against Bovine Leukemia virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "bovine leukemia virus" ;
    a owl:Class ;
    rdfs:label "bovine leukemia virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11901
    ] .

obo:VO_0012162
    obo:IAO_0000115 "A vaccine that protects against Marek's; disease virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Marek's; disease virus" ;
    a owl:Class ;
    rdfs:label "Marek's disease virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10390
    ] .

obo:VO_0012163
    obo:IAO_0000115 "A vaccine that protects against Marburg Virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Marburg Virus" ;
    a owl:Class ;
    rdfs:label "Marburg Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_186537
    ] .

obo:VO_0012165
    obo:IAO_0000115 "A vaccine that protects against Infectious Hematopoietic Necrosis Virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Infectious Hematopoietic Necrosis Virus" ;
    a owl:Class ;
    rdfs:label "Infectious Hematopoietic Necrosis Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11290
            ]
        )
    ] .

obo:VO_0012166
    obo:IAO_0000115 "A vaccine that protects against Rift Valley Fever virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Rift Valley Fever virus" ;
    a owl:Class ;
    rdfs:label "Rift Valley Fever virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11588
    ] .

obo:VO_0012167
    obo:IAO_0000115 "A vaccine that protects against Hantavirus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Hantavirus" ;
    a owl:Class ;
    rdfs:label "Hantavirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11598
    ] .

obo:VO_0012168
    obo:IAO_0000115 "A vaccine that protects against Herpes simplex virus type 1 and 2." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Herpes simplex virus type 1 and 2" ;
    a owl:Class ;
    rdfs:label "Herpes simplex virus type 1 and 2 vaccine" ;
    rdfs:subClassOf obo:VO_0000727, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10310
    ] .

obo:VO_0012169
    obo:IAO_0000115 "A vaccine that protects against Nipah virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Nipah virus" ;
    a owl:Class ;
    rdfs:label "Nipah virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_121791
    ] .

obo:VO_0012170
    obo:IAO_0000115 "A vaccine that protects against Hendra virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Hendra virus" ;
    a owl:Class ;
    rdfs:label "Hendra virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_63330
    ] .

obo:VO_0012171
    obo:IAO_0000115 "A vaccine that protects against Entamoeba histolytica." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Entamoeba histolytica" ;
    a owl:Class ;
    rdfs:label "Entamoeba histolytica vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5759
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5759
    ] .

obo:VO_0012173
    obo:IAO_0000115 "A Chlamydia vaccine that protects against Chlamydophila pneumoniae." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Chlamydophila pneumoniae vaccine" ;
    rdfs:subClassOf obo:VO_0000573, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83558
    ] .

obo:VO_0012174
    obo:IAO_0000115 "A Chlamydia bacterial vaccine against Chlamydophila psittaci infection" ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Chlamydophila psittaci vaccine" ;
    rdfs:subClassOf obo:VO_0000573, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83554
    ] .

obo:VO_0012175
    obo:IAO_0000115 "A vaccine that protects against Burkholderia pseudomallei." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Burkholderia pseudomallei" ;
    a owl:Class ;
    rdfs:label "Burkholderia pseudomallei vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_28450
    ] .

obo:VO_0012176
    obo:IAO_0000115 "A Chlamydia vaccine that protects against Chlamydia muridarum." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Chlamydia muridarum" ;
    a owl:Class ;
    rdfs:label "Chlamydia muridarum vaccine" ;
    rdfs:subClassOf obo:VO_0000573, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_83560
    ] .

obo:VO_0012177
    obo:IAO_0000115 "A vaccine that protects against Lassa Fever Virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Lassa Fever Virus" ;
    a owl:Class ;
    rdfs:label "Lassa Fever Virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11620
    ] .

obo:VO_0012178
    obo:IAO_0000115 "A vaccine that protects against Canine distemper virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "canine distemper virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11232
    ] .

obo:VO_0012179
    obo:IAO_0000115 "A vaccine that protects against Coccidioides spp." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Coccidioides spp. vaccine" ;
    a owl:Class ;
    rdfs:label "Coccidioides vaccine" ;
    rdfs:subClassOf obo:VO_0000267, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5500
    ] .

obo:VO_0012180
    obo:IAO_0000115 "A vaccine that protects against Canine parvovirus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Canine parvovirus" ;
    a owl:Class ;
    rdfs:label "canine parvovirus vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_10788
    ] .

obo:VO_0012181
    obo:IAO_0000115 "A vaccine that protects against Helicobacter pylori." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Helicobacter pylori" ;
    a owl:Class ;
    rdfs:label "Helicobacter pylori vaccine" ;
    rdfs:subClassOf obo:VO_0000165, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_210
    ] .

obo:VO_0012182
    obo:IAO_0000115 "A Campylobacter vaccine that protects against Campylobacter jejuni." ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Campylobacter jejuni vaccine" ;
    rdfs:subClassOf obo:VO_0000568, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_197
    ] .

obo:VO_0012183
    obo:IAO_0000115 "A vaccine that protects against SARS-CoV." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "SARS-CoV vaccine" ;
    a owl:Class ;
    rdfs:label "SARS vaccine" ;
    rdfs:subClassOf obo:VO_0004897, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_694009
    ] .

obo:VO_0012184
    obo:IAO_0000115 "A vaccine that protects against Trypanosoma brucei." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Trypanosoma brucei" ;
    a owl:Class ;
    rdfs:label "Trypanosoma brucei vaccine" ;
    rdfs:subClassOf obo:VO_0000417, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5691
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_5691
    ] .

obo:VO_0012185
    obo:IAO_0000115 "A vaccine that protects against Haemophilus influenzae." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Haemophilus influenzae" ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae vaccine" ;
    rdfs:subClassOf obo:VO_0000661 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000661
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_727
            ]
        )
    ] .

obo:VO_0012186
    obo:IAO_0000115 "A vaccine that protects against Yersinia enterocolitica." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Yersinia enterocolitica" ;
    a owl:Class ;
    rdfs:label "Yersinia enterocolitica vaccine" ;
    rdfs:subClassOf obo:VO_0000601, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_150052
    ] .

obo:VO_0012187
    obo:IAO_0000115 "A vaccine that protects against Clostridium botulinum ." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Clostridium botulinum" ;
    a owl:Class ;
    rdfs:label "Clostridium botulinum  vaccine" ;
    rdfs:subClassOf obo:VO_0000639, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] ;
    owl:equivalentClass [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_1491
    ] .

obo:VO_0012188
    obo:IAO_0000115 "A vaccine that protects against Western equine encephalomyelitis virus." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Western equine encephalomyelitis virus" ;
    a owl:Class ;
    rdfs:label "Western equine encephalomyelitis virus vaccine" ;
    rdfs:subClassOf obo:VO_0000609 ;
    owl:equivalentClass [
        a owl:Class ;
        owl:intersectionOf (obo:VO_0000609
            [
                a owl:Restriction ;
                owl:onProperty obo:VO_0003355 ;
                owl:someValuesFrom obo:NCBITaxon_11039
            ]
        )
    ] .

obo:VO_0012190
    obo:IAO_0000115 "A vaccine that protects against Tick-borne Encephalitis Virus (TBEV)." ;
    obo:IAO_0000117 "YH, ZX" ;
    obo:IAO_0000118 "Tick-borne Encephalitis Virus (TBEV)" ;
    a owl:Class ;
    rdfs:label "Tick-borne Encephalitis Virus (TBEV) vaccine" ;
    rdfs:subClassOf obo:VO_0000609, [
        a owl:Restriction ;
        owl:onProperty obo:VO_0003355 ;
        owl:someValuesFrom obo:NCBITaxon_11084
    ] .

obo:VO_0012212
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a Cancer vaccine"@en ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Cancer vaccine preparation" ;
    rdfs:seeAlso "VIOLIN Pathogen ID: 99" ;
    rdfs:subClassOf obo:VO_0000590 .

obo:VO_0012213
    obo:IAO_0000115 "A vaccine preparation that results in the generation of a Allergy vaccine"@en ;
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Allergy vaccine preparation" ;
    rdfs:seeAlso "VIOLIN Pathogen ID: 114" ;
    rdfs:subClassOf obo:VO_0000590 .

obo:VO_0012355
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Staphylococcus aureus protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0012356
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Streptococcus agalactiae protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0012357
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Streptococcus pyogenes protein" ;
    rdfs:subClassOf obo:VO_0010752 .

obo:VO_0012358
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "Treponema pallidum protein" ;
    rdfs:subClassOf obo:VO_0010751 .

obo:VO_0012359
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "YopH from Y. pestis strain: CO92, biovar: Orientalis" ;
    rdfs:seeAlso "Protegen ID: 51; NCBI Gene GI: 1172712; NCBI Protein GI: 16082755; NCBI Protein Accession: NP_395201; NCBITaxon: 214092" ;
    rdfs:subClassOf obo:VO_0010759, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012360
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "The oprF gene was cloned into plasmid vector pVR1020, and the plasmid vaccines were delivered to mice by biolistic (gene gun) intradermal inoculation. Following the initial immunization and two consecutive boosts, each at 2-week intervals, protection was demonstrated in a mouse model of chronic pulmonary infection by P. aeruginosa. Eight days postchallenge, both lungs were removed and examined. A significant reduction in the presence of severe macroscopic lesions, as well as in the number of bacteria present in the lungs, was seen [PubMed: 11292786]." ;
    rdfs:label "OprF" ;
    rdfs:seeAlso "Protegen ID: 843; NCBI Gene GI: 878442; NCBI Protein GI: 15596974; NCBI Protein Accession: NP_250468; NCBITaxon: 208964" ;
    rdfs:subClassOf obo:VO_0012370, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012361
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls [PubMed: 11500471]." ;
    rdfs:label "PcrV" ;
    rdfs:seeAlso "Protegen ID: 844; NCBI Gene GI: 882997; NCBI Protein GI: 15596903; NCBI Protein Accession: NP_250397; NCBITaxon: 208964" ;
    rdfs:subClassOf obo:VO_0012370, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012362
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant OprI protein was used to immunize mice, and was found to be protective against a challenge with a four- to fivefold 50% lethal dose of P. aeruginosa [PubMed: 2114360]." ;
    rdfs:label "OprI" ;
    rdfs:seeAlso "Protegen ID: 845; NCBI Gene GI: 879851; NCBI Protein GI: 15598049; NCBI Protein Accession: NP_251543; NCBITaxon: 208964" ;
    rdfs:subClassOf obo:VO_0012370, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012363
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "AY243312" ;
    rdfs:seeAlso "Protegen ID: 68; NCBI Nucleotide GI: 29692106" ;
    rdfs:subClassOf obo:VO_0010764, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012364
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In mice, a primary vaccination with Ag85B-encoding plasmid DNA (DNA-85B) was protective against Mycobacterium tuberculosis (MTB) infection and associated with Ag85B-specific CD4+ T cells producing IFN-gamma and controlling intramacrophagic MTB growth [PubMed: 17250590]." ;
    rdfs:label "Ag85B from M. tuberculosis H37Rv" ;
    rdfs:seeAlso "Protegen ID: 118; NCBI Gene GI: 885785; NCBI Protein GI: 15609023; NCBI Protein Accession: NC_000962.2; NCBITaxon: 1773" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012365
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:label "znuA" ;
    rdfs:seeAlso "Protegen ID: 228; NCBI Gene GI: 3341411; NCBI Protein GI: 62317941; NCBI Protein Accession: YP_223794; NCBITaxon: 262698" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012366
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intravenous vaccination with recombinant bacteria carrying expression plasmid for  MPB/MPT51 in BALB/c mice elicited significant protective responses, comparable to those evoked by a live Mycobacterium bovis BCG vaccine [PubMed: 15039321]." ;
    rdfs:label "FbpD" ;
    rdfs:seeAlso "Protegen ID: 814; NCBI Gene GI: 7562680; NCBI Protein GI: 224992215; NCBI Protein Accession: YP_002646905; NCBITaxon: 561275" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012367
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment """DNA vaccines encoding secreted proteins Ag85B and MPT64 protect mice from the tuberculosis H37Rv strain [PubMed: 15498274]. 
*Note* MPT64 in combination with Ag85B was protective, DNA vaccine of just MPT64 was mildly protective in mice.""" ;
    rdfs:label "MPT64" ;
    rdfs:seeAlso "Protegen ID: 815; NCBI Gene GI: 885925; NCBI Protein GI: 15609117; NCBI Protein Accession: NP_216496; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012368
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In a prophylactic vaccine model, immunization with the Mycobacterium tuberculosis protein ESAT-6 with LANAC adjuvant elicited significant protective immunity against aerosol challenge with virulent M. tuberculosis [PubMed: 16751377]." ;
    rdfs:label "ESAT-6" ;
    rdfs:seeAlso "Protegen ID: 816; NCBI Gene GI: 886209; NCBI Protein GI: 57117165; NCBI Protein Accession: YP_178023; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012369
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "DNA vaccines encoding  KatG antigen fused to TPA signal sequences evoked  a significant protective response in mice aerogenically challenged with low doses of Mycobacterium tuberculosis Erdman 17 to 21 days after the final immunization [PubMed: 10456931]." ;
    rdfs:label "KatG" ;
    rdfs:seeAlso "Protegen ID: 817; NCBI Gene GI: 885638; NCBI Protein GI: 15609045; NCBI Protein Accession: NP_216424; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012370
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice vaccinated with PstS-3 DNA demonstrated significant and sustained reduction in bacterial CFU numbers in spleen and lungs for 3 mo after M. tuberculosis challenge, as compared with CFU counts in mice vaccinated with control DNA [PubMed: 9916741]." ;
    rdfs:label "PstS3" ;
    rdfs:seeAlso "Protegen ID: 818; NCBI Gene GI: 885366; NCBI Protein GI: 57116798; NCBI Protein Accession: YP_177768; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012371
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A selection of previously identified protective Mycobacterium tuberculosis DNA vaccines were re-formulated as proteins and administered with a Th1-inducing adjuvant to help stimulate the relevant immune responses necessary for protection. One candidate (Rv1806-1807) induced protection in the guinea pig aerosol infection model 30 days post-challenge on the basis of reducing the bacterial burden of M. tuberculosis in the lungs [PubMed: 16520093]." ;
    rdfs:label "PE20" ;
    rdfs:seeAlso "Protegen ID: 819; NCBI Gene GI: 885537; NCBI Protein GI: 57116919; NCBI Protein Accession: YP_177843; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012372
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A selection of previously identified protective Mycobacterium tuberculosis DNA vaccines were re-formulated as proteins and administered with a Th1-inducing adjuvant to help stimulate the relevant immune responses necessary for protection. One candidate (Rv1806-1807) induced protection in the guinea pig aerosol infection model 30 days post-challenge on the basis of reducing the bacterial burden of M. tuberculosis in the lungs [PubMed: 16520093]." ;
    rdfs:label "PPE31" ;
    rdfs:seeAlso "Protegen ID: 820; NCBI Gene GI: 885072; NCBI Protein GI: 57116920; NCBI Protein Accession: YP_177653; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012373
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Purified preparations of HBHA were emulsified in a dimethyldioctadecylammonium bromide-monophosphoryl lipid A adjuvant and tested for the ability to reduce M. tuberculosis infection in the mouse aerosol challenge model for tuberculosis. The HBHA-containing vaccine gave a approximately 0.7-log reduction in CFU in both mouse lungs and spleens compared to adjuvant controls 28 days following challenge [PubMed: 15557600]." ;
    rdfs:label "HBHA" ;
    rdfs:seeAlso "Protegen ID: 821; NCBI Gene GI: 5211814; NCBI Protein GI: 148660242; NCBI Protein Accession: YP_001281765; NCBITaxon: 25177" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012374
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "immunization with the soluble recombinant rMTB41 protein plus adjuvant, a regimen known to generate primarily CD4+ T cells, resulted in induction of protection comparable to BCG in two well-established animal models of tuberculosis (mice and guinea pigs) [PubMed: 15917115]." ;
    rdfs:label "PPE14" ;
    rdfs:seeAlso "Protegen ID: 822; NCBI Gene GI: 885069; NCBI Protein GI: 57116795; NCBI Protein Accession: YP_177765; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012375
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "GAPDH (Gap) associated with murine IL-12 gene in a DNA vaccine formulation partially protected mice against experimental infection [PubMed: 12171297]." ;
    rdfs:label "Gap" ;
    rdfs:seeAlso "Protegen ID: 823; NCBI Gene GI: 3340207; NCBI Protein GI: 62290600; NCBI Protein Accession: YP_222393; NCBITaxon: 262698" ;
    rdfs:subClassOf obo:VO_0010758, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012376
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "rHtrA was found to be very immunogenic and partially protective in both the passive infant rat model of bacteremia and the active chinchilla model of otitis media [PubMed: 9488373]." ;
    rdfs:label "HtrA" ;
    rdfs:seeAlso "Protegen ID: 824; NCBI Protein GI: 2935168; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012377
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Orogastric immunization of mice with recombinant H. pylori HspA proteins protected 80%  of animals from a challenge dose of 10^4 Helicobacter felis bacteria [PubMed: 7604021]." ;
    rdfs:label "HspA" ;
    rdfs:seeAlso "Protegen ID: 825; NCBI Protein GI: 712830; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012378
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Orogastric immunization of mice with recombinant H. pylori HspB proteins protected 70% of animals from a challenge dose of 10^4 Helicobacter felis bacteria [PubMed: 7604021]." ;
    rdfs:label "HspB" ;
    rdfs:seeAlso "Protegen ID: 826; NCBI Protein GI: 712831; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012379
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were immunised with the citrate synthase protein by intra-Peyer's patch immunisation. Pre-immunisation with the citrate synthase protein led to a 84-91% reduction in H. pylori infection compared to unimmunised controls [PubMed: 10378424]." ;
    rdfs:label "GltA" ;
    rdfs:seeAlso "Protegen ID: 827; NCBI Protein GI: 2493711; NCBITaxon: 210" ;
    rdfs:subClassOf obo:VO_0010855, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012380
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Recombinant TbpA protein was used in a mouse intraperitoneal-infection model to determine their ability to protect against meningococcal infection and to induce cross-reactive and bactericidal antibodies. TbpA was found to afford protection against meningococcal challenge when administered as the sole immunogen [PubMed: 11179327]." ;
    rdfs:label "TbpA" ;
    rdfs:seeAlso "Protegen ID: 833; NCBI Protein GI: 8926211; NCBITaxon: 487" ;
    rdfs:subClassOf obo:VO_0010778, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012381
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In chimpanzees (Pan troglodytes), the primates most closely related to humans and that share a similar susceptibility to P. falciparum liver-stage infection, immunization with LSA-3 induced protection against successive heterologous challenges with large numbers of P. falciparum sporozoites [PubMed: 11062538]." ;
    rdfs:label "LSA-3" ;
    rdfs:seeAlso "Protegen ID: 834; NCBI Gene GI: 812783; NCBI Protein GI: 124801463; NCBI Protein Accession: XP_001349701; NCBITaxon: 36329" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012382
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "1 of 3 Monkeys vaccinated with EBA-175 was protected from challenge of parasitized erythrocytes [PubMed: 11471569]." ;
    rdfs:label "eba-175" ;
    rdfs:seeAlso "Protegen ID: 835; NCBI Gene GI: 2654998; NCBI Protein GI: 296004911; NCBI Protein Accession: XP_001349207; NCBITaxon: 36329" ;
    rdfs:subClassOf obo:VO_0010771, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012383
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with rPhpA-79 protein adjuvanted with monophosphoryl lipid A (for subcutaneous immunization) or a mutant cholera toxin, CT-E29H (for intranasal immunization), protected CBA/N mice against death and bacteremia, as well as reduced nasopharyngeal colonization, following intranasal challenge with a heterologous pneumococcal strain [PubMed: 11349048]." ;
    rdfs:label "phpA-79" ;
    rdfs:seeAlso "Protegen ID: 836; NCBI Protein GI: 13447096; NCBITaxon: 32630" ;
    rdfs:subClassOf obo:VO_0010779, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012384
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant OspA protein were protected from challenge with Borrelia burgdorferi [PubMed: 8168958]." ;
    rdfs:label "OspA" ;
    rdfs:seeAlso "Protegen ID: 838; NCBI Gene GI: 1194357; NCBI Protein GI: 11496927; NCBI Protein Accession: NP_045688; NCBITaxon: 224326" ;
    rdfs:subClassOf obo:VO_0012368, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012385
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant OspB protein were protected from challenge with Borrelia burgdorferi [PubMed: 8168958]." ;
    rdfs:label "OspB" ;
    rdfs:seeAlso "Protegen ID: 839; NCBI Gene GI: 1194340; NCBI Protein GI: 11496910; NCBI Protein Accession: NP_045689; NCBITaxon: 224326" ;
    rdfs:subClassOf obo:VO_0012368, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012386
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant OspC protein were protected from challenge with Borrelia burgdorferi [PubMed: 8168958]." ;
    rdfs:label "OspC" ;
    rdfs:seeAlso "Protegen ID: 840; NCBI Gene GI: 1194415; NCBI Protein GI: 11497024; NCBI Protein Accession: NP_047005; NCBITaxon: 224326" ;
    rdfs:subClassOf obo:VO_0012368, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012387
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant DbpA protein are protected against challenge with Borrelia burgdorferi [PubMed: 11035759]." ;
    rdfs:label "DbpA" ;
    rdfs:seeAlso "Protegen ID: 841; NCBI Gene GI: 8319341; NCBI Protein GI: 256041910; NCBI Protein Accession: YP_003110629; NCBITaxon: 521009" ;
    rdfs:subClassOf obo:VO_0012368, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012388
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In an attempt to generate a subunit vaccine in this experimental disease model, eukaryotic plasmid DNA expression vectors containing genes encoding either the wild-type or modified forms of recombinant listeriolysin O (hly) were generated and used for genetic vaccination of naive mice. Results of these studies indicate that the intramuscular immunization of mice with specifically designed plasmid DNA constructs encoding recombinant forms of listeriolysin O (hly) stimulates peptide-specific CD8+ immune T cells that exhibit in vitro cytotoxic activity. More importantly, such immunization can provide protective immunity against a subsequent challenge with viable L. monocytogenes [PubMed: 10384131]." ;
    rdfs:label "Hly" ;
    rdfs:seeAlso "Protegen ID: 842; NCBI Gene GI: 987033; NCBI Protein GI: 16802248; NCBI Protein Accession: NP_463733; NCBITaxon: 169963" ;
    rdfs:subClassOf obo:VO_0012369, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012389
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were immunized with a recombinant fragment of CNA protein, and were then challenged  with the S. aureus clinical isolate strain Phillips. At 14 d after inoculation, mortality in the collagen adhesin-vaccinated group was only 13%, compared with 87% in the control antigen immunized group [PubMed: 9637697]." ;
    rdfs:label "CNA" ;
    rdfs:seeAlso "Protegen ID: 846; NCBI Nucleotide GI: 387879; NCBI Protein GI: 387880; NCBI Protein Accession: AAA20874.1; NCBITaxon: 1280" ;
    rdfs:subClassOf obo:VO_0012355, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012390
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with recombinant ClfA and challenged with S. aureus developed less-severe arthritis than did mice immunized with a control antigen [PubMed: 11740733]." ;
    rdfs:label "ClfA" ;
    rdfs:seeAlso "Protegen ID: 847; NCBI Gene GI: 5330438; NCBI Protein GI: 151220968; NCBI Protein Accession: YP_001331790; NCBITaxon: 426430" ;
    rdfs:subClassOf obo:VO_0012355, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012391
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "An internal region from the transpeptidase domain from the PBP2a (encoded by mecA) was cloned into a mammalian expression vector, to be used as DNA vaccine in a Murine model. After three sets of DNA vaccination, the immune response represented by antibodies against a fragment of PBP2a was evaluated by enzyme linked immunosorbent assay (ELISA), showing a significant antibody response. The antibacterial effect of the DNA vaccine was evaluated by intraperitoneal immunization and challenge with a sublethal dose of MRSA for 7 days in mice. After the challenge, the number of bacteria from kidneys from immunized and non-immunized mice were determined. Kidneys from immunized mice had 1000 times less on bacteria than the positive controls (non-immunized mice) [PubMed: 12744903]." ;
    rdfs:label "MecA" ;
    rdfs:seeAlso "Protegen ID: 848; NCBI Gene GI: 2861157; NCBI Protein GI: 49482291; NCBI Protein Accession: YP_039515; NCBITaxon: 282458" ;
    rdfs:subClassOf obo:VO_0012355, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012392
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were immunized with fusion proteins encompassing the fibronectin-binding domain of a staphylococcal fibronectin-binding protein (FnBP-A). Vaccination of mice with recombinant FnBP resulted in significant protection against challenge with S. aureus [PubMed: 7975852]." ;
    rdfs:label "FnbA" ;
    rdfs:seeAlso "Protegen ID: 849; NCBI Protein GI: 120457; NCBITaxon: 93061" ;
    rdfs:subClassOf obo:VO_0012355, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012393
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization of mice with recombinant BPS protein by the subcutaneous route produced an efficient antigen-specific response, and immunized animals survived challenge with a lethal dose of a virulent strain [PubMed: 11796614]." ;
    rdfs:label "BPS" ;
    rdfs:seeAlso "Protegen ID: 850; NCBI Protein GI: 5327234; NCBITaxon: 1311" ;
    rdfs:subClassOf obo:VO_0012356, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012394
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Intranasal immunization of mice with either SfbI alone or coupled to cholera toxin B subunit (CTB) triggered efficient SfbI-specific humoral (mainly IgG) and lung mucosal (14% of total IgA) responses. SfbI-vaccinated animals showed 80% and 90% protection against homologous and heterologous challenge, respectively [PubMed: 10068585]." ;
    rdfs:label "SfbI" ;
    rdfs:seeAlso "Protegen ID: 851; NCBI Nucleotide GI: 511149; NCBI Protein GI: 511150; NCBI Protein Accession: CAA48133.1; NCBITaxon: 1314" ;
    rdfs:subClassOf obo:VO_0012357, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012395
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice subcutaneously or orally immunized with FBP54 survived significantly longer following the challenge with S. pyogenes than did nonimmunized mice [PubMed: 11159987]." ;
    rdfs:label "FBP54" ;
    rdfs:seeAlso "Protegen ID: 852; NCBI Nucleotide GI: 496254; NCBITaxon: 1314" ;
    rdfs:subClassOf obo:VO_0012357, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012396
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with FbpA were protected from challenge with group A streptococcus [PubMed: 19254483]." ;
    rdfs:label "FbaA" ;
    rdfs:seeAlso "Protegen ID: 853; NCBI Protein GI: 14915682; NCBITaxon: 1314" ;
    rdfs:subClassOf obo:VO_0012357, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012397
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice were intranasally immunized with diphtheria toxoid (DT) conjugated polypeptides encompassing a conformational-constrained B cell epitope of the M1 protein (J8). Vaccinated mice were challenged 10 days after the last boost by the intranasal route. Animals had 60% protection against challenge [PubMed: 16828529]." ;
    rdfs:label "Emm1" ;
    rdfs:seeAlso "Protegen ID: 854; NCBI Nucleotide GI: 311757; NCBI Protein GI: 311758; NCBI Protein Accession: CAA44062.1; NCBITaxon: 1314" ;
    rdfs:subClassOf obo:VO_0012357, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012398
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with Sib 35 enhanced survival rates in mice challenged with a GAS strain, while exhibiting no toxicity in hosts [PubMed: 15990202]." ;
    rdfs:label "Sib35" ;
    rdfs:seeAlso "Protegen ID: 855; NCBI Protein GI: 90567992; NCBITaxon: 342023" ;
    rdfs:subClassOf obo:VO_0012357, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012399
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with the recombinant GlpQ significantly protected rabbits from subsequent T. pallidum challenge, altering lesion development at the sites of challenge [PubMed: 9826352]." ;
    rdfs:label "GlpQ" ;
    rdfs:seeAlso "Protegen ID: 856; NCBI Gene GI: 2611763; NCBI Protein GI: 15639249; NCBI Protein Accession: NP_218698; NCBITaxon: 243276" ;
    rdfs:subClassOf obo:VO_0012358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012400
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Treponema pallidum-susceptible guinea pigs of strain C4D were immunized with recombinant T. pallidum antigen TmpB. Guinea pigs receiving TmpB antigen demonstrated protection expressed by the development of significantly (P less than 0.01) smaller, atypical lesions of significantly (P less than 0.01) shorter duration and devoid of or containing fewer T. pallidum organisms than lesions in the remaining immunized and control animals [PubMed: 1937794]." ;
    rdfs:label "TmpB" ;
    rdfs:seeAlso "Protegen ID: 857; NCBI Gene GI: 2611387; NCBI Protein GI: 15639756; NCBI Protein Accession: NP_219206; NCBITaxon: 243276" ;
    rdfs:subClassOf obo:VO_0012358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012401
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with recombinant Tp92 partially protected rabbits from subsequent T. pallidum challenge [PubMed: 10762571]." ;
    rdfs:label "Tp92" ;
    rdfs:seeAlso "Protegen ID: 858; NCBI Protein GI: 159158965; NCBITaxon: 243276" ;
    rdfs:subClassOf obo:VO_0012358, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012402
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Immunization with the recombinant Sip protein efficiently protected CD-1 mice against deadly challenges with six GBS strains of serotypes Ia/c, Ib, II/R, III, V, and VI [PubMed: 10992461]." ;
    rdfs:label "Sip" ;
    rdfs:seeAlso "Protegen ID: 859; NCBI Gene GI: 3685788; NCBI Protein GI: 76788047; NCBI Protein Accession: YP_328758; NCBITaxon: 205921" ;
    rdfs:subClassOf obo:VO_0012356, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012403
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination of mice with the Rib protein protected against two strains of capsular type III and two strains of type II, and vaccination with the alpha protein protected against one strain of type II and one strain of type Ib [PubMed: 8751893]." ;
    rdfs:label "Rib" ;
    rdfs:seeAlso "Protegen ID: 860; NCBI Protein GI: 1620648; NCBITaxon: 1311" ;
    rdfs:subClassOf obo:VO_0012356, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012404
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mice immunized with p60 encapsulated in  liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes [PubMed: 18433404]." ;
    rdfs:label "p60" ;
    rdfs:seeAlso "Protegen ID: 862; NCBI Protein GI: 215422507; NCBITaxon: 1639" ;
    rdfs:subClassOf obo:VO_0012369, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012405
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Mouse antiserum directed against the recombinant NucA protein was reactive on Western immunoblots and whole-cell ELISA with all H. influenzae strains tested including Eagan and was bactericidal for two heterologous strains tested. The antiserum also resulted in a log reduction in bacteremia, in an infant-rat protection study with H. influenzae type b as the challenge strain [PubMed: 10768940]." ;
    rdfs:label "NucA" ;
    rdfs:seeAlso "Protegen ID: 863; NCBI Protein GI: 4929317; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012406
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "When chinchillas were immunized with recombinant P1 (rP1) obtained from one of these isolates (BCH-3), all animals developed antibodies specific for rP1. Immunized animals were protected against disease when challenged with BCH-3, but not with an ompP1 mutant of BCH-3 or a strain (BCH-2) possessing a heterologous P1 (91% identity). We conclude that (i) while P1 induces protection against NTHI-mediated otitis media, development of a polyvalent vaccine reflecting the variability of P1 would be necessary to construct an efficacious vaccine [PubMed: 10899849]." ;
    rdfs:label "OmpP1" ;
    rdfs:seeAlso "Protegen ID: 864; NCBI Protein GI: 9716645; NCBITaxon: 727" ;
    rdfs:subClassOf obo:VO_0010772, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012407
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "Vaccination with the recombinant PstS-1 antigen and cholera toxin significantly protected against the challenge given 10 days later, but only marginally after 12 weeks [PubMed: 10869767]." ;
    rdfs:label "PstS1" ;
    rdfs:seeAlso "Protegen ID: 865; NCBI Gene GI: 885724; NCBI Protein GI: 57116801; NCBI Protein Accession: YP_177770; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012408
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "In an ex vivo transfection approach with a retroviral vector a single antigen (hsp70) could evoke strong protection in mice [PubMed: 9234527]." ;
    rdfs:label "DnaK" ;
    rdfs:seeAlso "Protegen ID: 866; NCBI Gene GI: 885946; NCBI Protein GI: 15607491; NCBI Protein Accession: NP_214864; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0012409
    obo:IAO_0000117 "YH, ZX" ;
    a owl:Class ;
    rdfs:comment "A single DNA vaccine encoding the MPT-83 tuberculosis antigens evoked partial protection against an aerogenic challenge with M. tuberculosis Erdman in the mouse model of pulmonary tuberculosis [PubMed: 10715531]." ;
    rdfs:label "MPT83" ;
    rdfs:seeAlso "Protegen ID: 867; NCBI Gene GI: 887155; NCBI Protein GI: 15610010; NCBI Protein Accession: NP_217389; NCBITaxon: 83332" ;
    rdfs:subClassOf obo:VO_0010770, [
        a owl:Restriction ;
        owl:onProperty obo:RO_0000087 ;
        owl:someValuesFrom obo:VO_0000457
    ] .

obo:VO_0015001
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/803365" ;
    obo:VO_0003198 803365 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 720 UNT/ML / Hepatitis B Surface Antigen Vaccine 0.02 MG/ML [Twinrix]"@en ;
    rdfs:subClassOf obo:VO_0003451 .

obo:VO_0015003
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/803371" ;
    obo:VO_0003198 803371 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis A Vaccine (Inactivated) Strain HM175 720 UNT/ML / Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Prefilled Syringe [Twinrix]"@en ;
    rdfs:subClassOf obo:VO_0015006 .

obo:VO_0015004
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/803367" ;
    obo:VO_0003198 803367 ;
    a owl:Class ;
    rdfs:label "1 ML Hepatitis A Vaccine (Inactivated) Strain HM175 720 UNT/ML / Hepatitis B Surface Antigen Vaccine 0.02 MG/ML Injection [Twinrix]"@en ;
    rdfs:subClassOf obo:VO_0015005 .

obo:VO_0015005
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657671" ;
    obo:VO_0003198 1657671 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 / Hepatitis B Surface Antigen Vaccine Injection [Twinrix]"@en ;
    rdfs:subClassOf obo:VO_0003451 .

obo:VO_0015006
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/803370" ;
    obo:VO_0003198 803370 ;
    a owl:Class ;
    rdfs:label "Hepatitis A Vaccine (Inactivated) Strain HM175 / Hepatitis B Surface Antigen Vaccine Prefilled Syringe [Twinrix]"@en ;
    rdfs:subClassOf obo:VO_0003451 .

obo:VO_0015008
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300468" ;
    obo:VO_0003198 1300468 ;
    a owl:Class ;
    rdfs:label "0.5 ML Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.068 MG/ML Injection [ActHIB]"@en ;
    rdfs:subClassOf obo:VO_0015010 .

obo:VO_0015009
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300467" ;
    obo:VO_0003198 1300467 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.068 MG/ML [ActHIB]"@en ;
    rdfs:subClassOf obo:VO_0015011 .

obo:VO_0015010
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658093" ;
    obo:VO_0003198 1658093 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine Injection [ActHIB]"@en ;
    rdfs:subClassOf obo:VO_0015011 .

obo:VO_0015011
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1169156" ;
    obo:VO_0003198 1169156 ;
    a owl:Class ;
    rdfs:label "ActHIB Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000004 .

obo:VO_0015012
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300465" ;
    obo:VO_0003198 1300465 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.068 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0015013 .

obo:VO_0015013
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300464" ;
    obo:VO_0003198 1300464 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0015014, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000031
    ] .

obo:VO_0015014
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798279" ;
    obo:VO_0003198 798279 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000627, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000084
    ] .

obo:VO_0015015
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1300466" ;
    obo:VO_0003198 1300466 ;
    a owl:Class ;
    rdfs:label "0.5 ML Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.068 MG/ML Injection"@en ;
    rdfs:subClassOf obo:VO_0015016 .

obo:VO_0015016
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658069" ;
    obo:VO_0003198 1658069 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine Injection"@en ;
    rdfs:subClassOf obo:VO_0015017 .

obo:VO_0015017
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1160291" ;
    obo:VO_0003198 1160291 ;
    a owl:Class ;
    rdfs:label "Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0015014 .

obo:VO_0015019
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1166419" ;
    obo:VO_0003198 1166419 ;
    a owl:Class ;
    rdfs:label "Engerix-B Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0010711 .

obo:VO_0015020
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658143" ;
    obo:VO_0003198 1658143 ;
    a owl:Class ;
    rdfs:label "Hepatitis B Surface Antigen Vaccine Injection [Engerix-B]"@en ;
    rdfs:subClassOf obo:VO_0015019 .

obo:VO_0015022
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1190916" ;
    obo:VO_0003198 1190916 ;
    a owl:Class ;
    rdfs:label "0.5 ML diphtheria toxoid vaccine, inactivated 4 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection [Tenivac]"@en ;
    rdfs:subClassOf obo:VO_0015025 .

obo:VO_0015023
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1190919" ;
    obo:VO_0003198 1190919 ;
    a owl:Class ;
    rdfs:label "0.5 ML diphtheria toxoid vaccine, inactivated 4 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Prefilled Syringe [Tenivac]"@en ;
    rdfs:subClassOf obo:VO_0015024 .

obo:VO_0015024
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1190918" ;
    obo:VO_0003198 1190918 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Prefilled Syringe [Tenivac]"@en ;
    rdfs:subClassOf obo:VO_0000102 .

obo:VO_0015025
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657592" ;
    obo:VO_0003198 1657592 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated / tetanus toxoid vaccine, inactivated Injection [Tenivac]"@en ;
    rdfs:subClassOf obo:VO_0000102 .

obo:VO_0015026
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1190914" ;
    obo:VO_0003198 1190914 ;
    a owl:Class ;
    rdfs:label "Tenivac Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000102 .

obo:VO_0015027
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1190912" ;
    obo:VO_0003198 1190912 ;
    a owl:Class ;
    rdfs:label "diphtheria toxoid vaccine, inactivated 4 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Tenivac]"@en ;
    rdfs:subClassOf obo:VO_0000102 .

obo:VO_0015028
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292427" ;
    obo:VO_0003198 1292427 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 2700 UNT/ML [Varivax]"@en ;
    rdfs:subClassOf obo:VO_0000119 .

obo:VO_0015029
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1292459" ;
    obo:VO_0003198 1292459 ;
    a owl:Class ;
    rdfs:label "0.5 ML Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain 2700 UNT/ML Injection [Varivax]"@en ;
    rdfs:subClassOf obo:VO_0015031 .

obo:VO_0015030
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1187569" ;
    obo:VO_0003198 1187569 ;
    a owl:Class ;
    rdfs:label "Varivax Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000119 .

obo:VO_0015031
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658008" ;
    obo:VO_0003198 1658008 ;
    a owl:Class ;
    rdfs:label "Varicella-Zoster Virus Vaccine Live (Oka-Merck) strain Injection [Varivax]"@en ;
    rdfs:subClassOf obo:VO_0015030 .

obo:VO_0015032
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798267" ;
    obo:VO_0003198 798267 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 18 Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003302 .

obo:VO_0015033
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597084" ;
    obo:VO_0003198 1597084 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 18 Vaccine 0.08 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003302 .

obo:VO_0015034
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597099" ;
    obo:VO_0003198 1597099 ;
    a owl:Class ;
    rdfs:label "0.5 ML L1 protein, Human papillomavirus type 11 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 16 Vaccine 0.12 MG/ML / L1 protein, Human papillomavirus type 18 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 31 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 33 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 45 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 52 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 58 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 6 Vaccine 0.06 MG/ML Injection [Gardasil 9]"@en ;
    rdfs:subClassOf obo:VO_0015037, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015033
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015040
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015041
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015042
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015043
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015044
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
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    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
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    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0015047
    ] .

obo:VO_0015035
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597096" ;
    obo:VO_0003198 1597096 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 11 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 16 Vaccine 0.12 MG/ML / L1 protein, Human papillomavirus type 18 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 31 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 33 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 45 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 52 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 58 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 6 Vaccine 0.06 MG/ML [Gardasil 9]"@en ;
    rdfs:subClassOf obo:VO_0003075 .

obo:VO_0015036
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597103" ;
    obo:VO_0003198 1597103 ;
    a owl:Class ;
    rdfs:label "0.5 ML L1 protein, Human papillomavirus type 11 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 16 Vaccine 0.12 MG/ML / L1 protein, Human papillomavirus type 18 Vaccine 0.08 MG/ML / L1 protein, Human papillomavirus type 31 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 33 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 45 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 52 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 58 Vaccine 0.04 MG/ML / L1 protein, Human papillomavirus type 6 Vaccine 0.06 MG/ML Prefilled Syringe [Gardasil 9]"@en ;
    rdfs:subClassOf obo:VO_0015039 .

obo:VO_0015037
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000118 "L1 protein, Human papillomavirus type 11 Vaccine / L1 protein, Human papillomavirus type 16 Vaccine / L1 protein, Human papillomavirus type 18 Vaccine / L1 protein, Human papillomavirus type 31 Vaccine / L1 protein, Human papillomavirus type 33 Vaccine / L1 protein, Human papillomavirus type 45 Vaccine / L1 protein, Human papillomavirus type 52 Vaccine / L1 protein, Human papillomavirus type 58 Vaccine / L1 protein, Human papillomavirus type 6 Vaccine Injection [Gardasil 9]"@en ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1656976" ;
    obo:VO_0003198 1656976 ;
    a owl:Class ;
    rdfs:label "Gardasil 9 injection" ;
    rdfs:subClassOf obo:VO_0003075 .

obo:VO_0015038
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597098" ;
    obo:VO_0003198 1597098 ;
    a owl:Class ;
    rdfs:label "Gardasil 9 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0003075 .

obo:VO_0015039
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000118 "L1 protein, Human papillomavirus type 11 Vaccine / L1 protein, Human papillomavirus type 16 Vaccine / L1 protein, Human papillomavirus type 18 Vaccine / L1 protein, Human papillomavirus type 31 Vaccine / L1 protein, Human papillomavirus type 33 Vaccine / L1 protein, Human papillomavirus type 45 Vaccine / L1 protein, Human papillomavirus type 52 Vaccine / L1 protein, Human papillomavirus type 58 Vaccine / L1 protein, Human papillomavirus type 6 Vaccine Prefilled Syringe [Gardasil 9]"@en ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597102" ;
    obo:VO_0003198 1597102 ;
    a owl:Class ;
    rdfs:label "Gardasil 9 prefilled syringe" ;
    rdfs:subClassOf obo:VO_0003075 .

obo:VO_0015040
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798263" ;
    obo:VO_0003198 798263 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 11 Vaccine 0.08 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003301 .

obo:VO_0015041
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597083" ;
    obo:VO_0003198 1597083 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 16 Vaccine 0.12 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003303 .

obo:VO_0015042
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597085" ;
    obo:VO_0003198 1597085 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 31 Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003304 .

obo:VO_0015043
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597086" ;
    obo:VO_0003198 1597086 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 33 Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003305 .

obo:VO_0015044
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597087" ;
    obo:VO_0003198 1597087 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 45 Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003306 .

obo:VO_0015045
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597088" ;
    obo:VO_0003198 1597088 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 52 Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003307 .

obo:VO_0015046
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597089" ;
    obo:VO_0003198 1597089 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 58 Vaccine 0.04 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003308 .

obo:VO_0015047
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1597090" ;
    obo:VO_0003198 1597090 ;
    a owl:Class ;
    rdfs:label "L1 protein, Human papillomavirus type 6 Vaccine 0.06 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0003300 .

obo:VO_0015048
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804184" ;
    obo:VO_0003198 804184 ;
    a owl:Class ;
    rdfs:label "Measles Virus Vaccine Live, Enders' attenuated Edmonston strain 2000 UNT/ML / Mumps Virus Vaccine Live, Jeryl Lynn Strain 25000 UNT/ML / Rubella Virus Vaccine Live (Wistar RA 27-3 Strain) 2000 UNT/ML [M-M-R II]"@en ;
    rdfs:subClassOf obo:VO_0000069 .

obo:VO_0015049
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804186" ;
    obo:VO_0003198 804186 ;
    a owl:Class ;
    rdfs:label "0.5 ML Measles Virus Vaccine Live, Enders' attenuated Edmonston strain 2000 UNT/ML / Mumps Virus Vaccine Live, Jeryl Lynn Strain 25000 UNT/ML / Rubella Virus Vaccine Live (Wistar RA 27-3 Strain) 2000 UNT/ML Injection [M-M-R II]"@en ;
    rdfs:subClassOf obo:VO_0015048 .

obo:VO_0015050
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658025" ;
    obo:VO_0003198 1658025 ;
    a owl:Class ;
    rdfs:label "Measles Virus Vaccine Live, Enders' attenuated Edmonston strain / Mumps Virus Vaccine Live, Jeryl Lynn Strain / Rubella Virus Vaccine Live (Wistar RA 27-3 Strain) Injection [M-M-R II]"@en ;
    rdfs:subClassOf obo:VO_0015051 .

obo:VO_0015051
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1184336" ;
    obo:VO_0003198 1184336 ;
    a owl:Class ;
    rdfs:label "M-M-R II Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000069 .

obo:VO_0015052
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804179" ;
    obo:VO_0003198 804179 ;
    a owl:Class ;
    rdfs:label "Measles Virus Vaccine Live, Enders' attenuated Edmonston strain"@en ;
    rdfs:subClassOf obo:VO_0000654, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000069
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000091
    ] .

obo:VO_0015053
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804180" ;
    obo:VO_0003198 804180 ;
    a owl:Class ;
    rdfs:label "Measles Virus Vaccine Live, Enders' attenuated Edmonston strain 2000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0015052 .

obo:VO_0015054
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/762817" ;
    obo:VO_0003198 762817 ;
    a owl:Class ;
    rdfs:label "Rubella Virus Vaccine Live (Wistar RA 27-3 Strain)"@en ;
    rdfs:subClassOf obo:VO_0010637, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000069
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000050 ;
        owl:someValuesFrom obo:VO_0000091
    ] .

obo:VO_0015055
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/762818" ;
    obo:VO_0003198 762818 ;
    a owl:Class ;
    rdfs:label "Rubella Virus Vaccine Live (Wistar RA 27-3 Strain) 2000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0015054 .

obo:VO_0015056
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798372" ;
    obo:VO_0003198 798372 ;
    a owl:Class ;
    rdfs:label "Mumps Virus Vaccine Live, Jeryl Lynn Strain"@en ;
    rdfs:subClassOf obo:VO_0000656 .

obo:VO_0015057
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798373" ;
    obo:VO_0003198 798373 ;
    a owl:Class ;
    rdfs:label "Mumps Virus Vaccine Live, Jeryl Lynn Strain 40000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0015056 .

obo:VO_0015058
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1156380" ;
    obo:VO_0003198 1156380 ;
    a owl:Class ;
    rdfs:label "Mumps Virus Vaccine Live, Jeryl Lynn Strain Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0000656 .

obo:VO_0015059
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/798375" ;
    obo:VO_0003198 798375 ;
    a owl:Class ;
    rdfs:label "Mumps Virus Vaccine Live, Jeryl Lynn Strain 40000 UNT/ML Injectable Solution"@en ;
    rdfs:subClassOf obo:VO_0000656 .

obo:VO_0015060
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/804181" ;
    obo:VO_0003198 804181 ;
    a owl:Class ;
    rdfs:label "Mumps Virus Vaccine Live, Jeryl Lynn Strain 25000 UNT/ML"@en ;
    rdfs:subClassOf obo:VO_0015056 .

obo:VO_0015063
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797629" ;
    obo:VO_0003198 797629 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0015064
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797630" ;
    obo:VO_0003198 797630 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0015063 .

obo:VO_0015066
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797632" ;
    obo:VO_0003198 797632 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0015067 .

obo:VO_0015067
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797631" ;
    obo:VO_0003198 797631 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0015068
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797634" ;
    obo:VO_0003198 797634 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0015070 .

obo:VO_0015069
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797633" ;
    obo:VO_0003198 797633 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0015070
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797635" ;
    obo:VO_0003198 797635 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine"@en ;
    rdfs:subClassOf obo:VO_0000053 .

obo:VO_0015071
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/797634" ;
    obo:VO_0003198 797634 ;
    a owl:Class ;
    rdfs:label "Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML"@en ;
    rdfs:subClassOf obo:VO_0015069 .

obo:VO_0015080
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658702" ;
    obo:VO_0003198 1658702 ;
    a owl:Class ;
    rdfs:label "Fluzone 2015-2016"@en ;
    rdfs:subClassOf obo:VO_0000047, [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0000200
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003470
    ], [
        a owl:Restriction ;
        owl:onProperty obo:BFO_0000051 ;
        owl:someValuesFrom obo:VO_0003488
    ] .

obo:VO_0015081
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1658705" ;
    obo:VO_0003198 1658705 ;
    a owl:Class ;
    rdfs:label "Fluzone 2015-2016 Injectable Product"@en ;
    rdfs:subClassOf obo:VO_0015080 .

obo:VO_0015084
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657128" ;
    obo:VO_0003198 1657128 ;
    a owl:Class ;
    rdfs:label "Influenza A virus (H1N1) antigen"@en ;
    rdfs:subClassOf obo:VO_0000919 .

obo:VO_0015085
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657131" ;
    obo:VO_0003198 1657131 ;
    a owl:Class ;
    rdfs:label "influenza A virus (H3N2) antigen"@en ;
    rdfs:subClassOf obo:VO_0000919 .

obo:VO_0015086
    obo:IAO_0000117 "Khadeejah Khan, Oliver He" ;
    obo:IAO_0000119 "http://purl.bioontology.org/ontology/RXNORM/1657134" ;
    obo:VO_0003198 1657134 ;
    a owl:Class ;
    rdfs:label "influenza B virus antigen"@en ;
    rdfs:subClassOf obo:VO_0000919 .

obo:VO_0015978
    obo:IAO_0000115 "a role that inheres in a cell line repository organization." ;
    obo:IAO_0000117 "SS, YH" ;
    a owl:Class ;
    rdfs:label "cell line repository role"@en ;
    rdfs:subClassOf obo:BFO_0000023 .

obo:activates
    a owl:ObjectProperty .

obo:bearer_of
    a owl:ObjectProperty .

chebi:charge
    a owl:AnnotationProperty .

chebi:formula
    a owl:AnnotationProperty .

chebi:inchi
    a owl:AnnotationProperty .

chebi:inchikey
    a owl:AnnotationProperty .

chebi:mass
    a owl:AnnotationProperty .

chebi:monoisotopicmass
    a owl:AnnotationProperty .

chebi:smiles
    a owl:AnnotationProperty .

<http://purl.obolibrary.org/obo/iao.owl>
    a owl:NamedIndividual .

obo:inheres_in-obso
    a owl:FunctionalProperty, owl:ObjectProperty ;
    rdfs:subPropertyOf oboInOwl:ObsoleteProperty .

ncbitaxon:has_rank
    obo:IAO_0000115 "A metadata relation between a class and its taxonomic rank (eg species, family)"^^xsd:string ;
    oboInOwl:hasOBONamespace "ncbi_taxonomy"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:label "has_rank" .

<http://purl.obolibrary.org/obo/obi.owl>
    protege:defaultLanguage "en"^^xsd:string ;
    obo:IAO_0000589 "Ontology for Biomedical Investigations"@en ;
    dc:contributor "Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester"@en ;
    dc:creator "Alan Ruttenberg"@en, "Allyson Lister"@en, "Barry Smith"@en, "Bill Bug"@en, "Bjoern Peters"@en, "Carlo Torniai"@en, "Chris Mungall"@en, "Chris Stoeckert"@en, "Chris Taylor"@en, "Christian Bolling"@en, "Cristian Cocos"@en, "Daniel Rubin"@en, "Daniel Schober"@en, "Dawn Field"@en, "Dirk Derom"@en, "Elisabetta Manduchi"@en, "Eric Deutsch"@en, "Frank Gibson"@en, "Gilberto Fragoso"@en, "Helen C. Causton"@en, "Helen Parkinson"@en, "Holger Stenzhorn"@en, "James A. Overton"@en, "James Malone"@en, "Jay Greenbaum"@en, "Jeffrey Grethe"@en, "Jennifer Fostel"@en, "Jessica Turner"@en, "Jie Zheng"@en, "Joe White"@en, "John Westbrook"@en, "Kevin Clancy"@en, "Larisa Soldatova"@en, "Lawrence Hunter"@en, "Liju Fan"@en, "Luisa Montecchi"@en, "Matthew Brush"@en, "Matthew Pocock"@en, "Melanie Courtot"@en, "Melissa Haendel"@en, "Mervi Heiskanen"@en, "Monnie McGee"@en, "Norman Morrison"@en, "Philip Lord"@en, "Philippe Rocca-Serra"@en, "Pierre Grenon"@en, "Richard Bruskiewich"@en, "Richard Scheuermann"@en, "Robert Stevens"@en, "Ryan R. Brinkman"@en, "Stefan Wiemann"@en, "Susanna-Assunta Sansone"@en, "Tanya Gray"@en, "Tina Hernandez-Boussard"@en, "Trish Whetzel"@en, "Yongqun He"@en ;
    dc:date "2009-07-31"^^xsd:date ;
    dc:description "The Ontology for Biomedical Investigations (OBI) is build in a collaborative, international effort and will serve as a resource for annotating biomedical investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. This ontology arose from the Functional Genomics Investigation Ontology (FuGO) and will contain both terms that are common to all biomedical investigations, including functional genomics investigations and those that are more domain specific."@en ;
    dc:format "OWL-DL"@en ;
    dc:subject "An ontology for the annotation of biomedical and functional genomics experiments."@en ;
    terms:license "http://creativecommons.org/licenses/by/4.0/" ;
    terms:title "Ontology for Biomedical Investigations" ;
    a owl:NamedIndividual ;
    rdfs:comment "Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them."^^xsd:string ;
    owl:versionInfo "2021-04-06"^^xsd:string .

<http://purl.obolibrary.org/obo/vo.owl>
    protege:defaultLanguage "en" ;
    dc:contributor "Chris mungall", "Erica Marcos", "Ningxian Fan", "Paul Fabry", "Randi Vita"@en, "Ryan R. Brinkman", "Shunzhou Deng"@en ;
    dc:creator "Alan Ruttenburg", "Alexander D. Diehl", "Amogh Madireddi", "Anna Maria Masci"@en, "Anthony Huffman"@en, "Barry Smith", "Bjoern Peters", "Edison Ong", "Hong Yu", "Jason Hu", "Jie Zheng", "Kallan Roan", "Khadeejah Khan", "Lindsay Cowell", "Melanie Courtot", "Ningxian Fan"@en, "Omar Tibi", "Philip Huang"@en, "Randi Vita", "Rebecca Racz", "Richard H. Scheuermann", "Rohit Goru"@en, "Ronak Sutariya"@en, "Samantha G. Sayers (SGS)", "Thomas Todd", "Yongqun \"Oliver\" He (YH)"@en, "Yu Lin (YL)"@en, "Zuoshuang \"Allen\" Xiang"@en ;
    dc:date "June 24, 2022"@en ;
    dc:description "The Vaccine Ontology (VO) is a biomedical ontology in the domain of vaccine and vaccination. VO aims to standardize vaccine annotation, integrate various vaccine data, and support computer-assisted reasoning. VO supports basic vaccine R&D and clincal vaccine usage. VO is being developed as a community-based ontology with support and collaborations from the vaccine and bio-ontology communities."@en ;
    dc:format "OWL-DL"@en ;
    dc:license <http://creativecommons.org/licenses/by/4.0/> ;
    dc:subject "An ontology in the domain of vaccine and vaccination"@en ;
    dc:title "Vaccine Ontology"@en ;
    a owl:Ontology ;
    owl:versionInfo "1.1.198"@en .

<http://purl.obolibrary.org/obo/vo/ontorat/PR_P0DTC4>
    a owl:Class ;
    rdfs:subClassOf obo:VO_0004990 .

dc:contributor
    dc:description """Examples of a Contributor include a person, an 
         organisation, or a service.  Typically, the name of a 
         Contributor should be used to indicate the entity."""@en-us ;
    oboInOwl:hasDbXref dc:contributor ;
    oboInOwl:hasOBONamespace "uberon"^^xsd:string ;
    oboInOwl:id "dc-contributor"^^xsd:string ;
    oboInOwl:is_metadata_tag true ;
    oboInOwl:shorthand "dc-contributor"^^xsd:string ;
    a owl:AnnotationProperty ;
    rdfs:comment """An entity responsible for making contributions to the
         content of the resource."""@en-us ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> ;
    rdfs:label "Contributor", "Contributor"@en-us, "contributor" .

dc:coverage
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

dc:creator
    dc:description """Examples of a Creator include a person, an organisation,
         or a service.  Typically, the name of a Creator should 
         be used to indicate the entity."""@en-us ;
    a owl:AnnotationProperty ;
    rdfs:comment """An entity primarily responsible for making the content 
         of the resource."""@en-us ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> ;
    rdfs:label "Creator", "Creator"@en-us, "creator" .

dc:date
    dc:description """Typically, Date will be associated with the creation or
         availability of the resource.  Recommended best practice
         for encoding the date value is defined in a profile of
         ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format."""@en-us ;
    a owl:AnnotationProperty ;
    rdfs:comment """A date associated with an event in the life cycle of the
         resource."""@en-us ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> ;
    rdfs:label "Date", "Date"@en-us .

dc:description
    dc:description """Description may include but is not limited to: an abstract,
         table of contents, reference to a graphical representation
         of content or a free-text account of the content."""@en-us ;
    a owl:AnnotationProperty ;
    rdfs:comment "An account of the content of the resource."@en-us ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> ;
    rdfs:label "Description", "Description"@en-us .

dc:format
    dc:description """Typically, Format may include the media-type or dimensions of
         the resource. Format may be used to determine the software,
         hardware or other equipment needed to display or operate the
         resource. Examples of dimensions include size and duration.
         Recommended best practice is to select a value from a
         controlled vocabulary (for example, the list of Internet Media
         Types [MIME] defining computer media formats)."""@en-us ;
    a owl:AnnotationProperty ;
    rdfs:comment "The physical or digital manifestation of the resource."@en-us ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> ;
    rdfs:label "Format", "Format"@en-us .

dc:identifier
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

dc:language
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

dc:license
    a owl:AnnotationProperty .

dc:publisher
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

dc:relation
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

dc:rights
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

dc:source
    dc:description """The present resource may be derived from the Source resource
         in whole or in part.  Recommended best practice is to reference
         the resource by means of a string or number conforming to a
         formal identification system."""@en-us ;
    a owl:AnnotationProperty ;
    rdfs:comment """A reference to a resource from which the present resource
         is derived."""@en-us ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> ;
    rdfs:label "Source", "Source"@en-us .

dc:subject
    dc:description """Typically, a Subject will be expressed as keywords,
         key phrases or classification codes that describe a topic
         of the resource.  Recommended best practice is to select 
         a value from a controlled vocabulary or formal 
         classification scheme."""@en-us ;
    a owl:AnnotationProperty ;
    rdfs:comment "The topic of the content of the resource."@en-us ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> ;
    rdfs:label "Subject and Keywords", "Subject and Keywords"@en-us .

dc:title
    a owl:AnnotationProperty ;
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

dc:type
    rdfs:isDefinedBy <http://purl.org/dc/elements/1.1/> .

terms:license
    obo:IAO_0000117 "Mark Miller"^^xsd:string ;
    dc:date "2018-05-11T13:47:29Z"^^xsd:dateTime ;
    a owl:AnnotationProperty .

terms:title
    a owl:AnnotationProperty .

oboInOwl:ObsoleteClass
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

oboInOwl:ObsoleteProperty
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:ObjectProperty .

oboInOwl:created_by
    a owl:AnnotationProperty .

oboInOwl:creation_date
    a owl:AnnotationProperty .

oboInOwl:hasAlternativeId
    a owl:AnnotationProperty ;
    rdfs:label "has_alternative_id" .

oboInOwl:hasBroadSynonym
    a owl:AnnotationProperty ;
    rdfs:label "has_broad_synonym" .

oboInOwl:hasDbXref
    a owl:AnnotationProperty ;
    rdfs:label "database_cross_reference" .

oboInOwl:hasExactSynonym
    a owl:AnnotationProperty ;
    rdfs:label "has_exact_synonym" .

oboInOwl:hasNarrowSynonym
    a owl:AnnotationProperty ;
    rdfs:label "has_narrow_synonym" .

oboInOwl:hasOBONamespace
    a owl:AnnotationProperty ;
    rdfs:label "has_obo_namespace" .

oboInOwl:hasRelatedSynonym
    a owl:AnnotationProperty ;
    rdfs:label "has_related_synonym" .

oboInOwl:hasSynonym
    a owl:AnnotationProperty .

oboInOwl:hasURI
    a owl:AnnotationProperty .

oboInOwl:id
    a owl:AnnotationProperty .

oboInOwl:inSubset
    a owl:AnnotationProperty ;
    rdfs:label "in_subset" .

oboInOwl:is_metadata_tag
    a owl:AnnotationProperty .

oboInOwl:shorthand
    a owl:AnnotationProperty ;
    rdfs:label "shorthand" .

rdf:PlainLiteral
    a rdfs:Datatype .

rdfs:Literal
    a rdfs:Datatype .

rdfs:comment
    a owl:AnnotationProperty .

rdfs:isDefinedBy
    a owl:AnnotationProperty .

rdfs:label
    obo:IAO_0000111 "label" ;
    a owl:AnnotationProperty ;
    rdfs:label "label" .

rdfs:seeAlso
    a owl:AnnotationProperty .

xsd:date
    a rdfs:Datatype .

xsd:dateTime
    a rdfs:Datatype .

xsd:float
    a rdfs:Datatype .

xsd:integer
    a rdfs:Datatype .

xsd:nonNegativeInteger
    a rdfs:Datatype .

xsd:string
    a rdfs:Datatype .

owl:Thing
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> ;
    a owl:Class .

owl:priorVersion
    a owl:AnnotationProperty .

owl:topObjectProperty
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/ro.owl> ;
    a owl:ObjectProperty .

owl:versionInfo
    a owl:AnnotationProperty .

foaf:depicted_by
    a owl:AnnotationProperty .

foaf:homepage
    a owl:AnnotationProperty .

foaf:page
    a owl:AnnotationProperty .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/obi.owl> .

[]
    obo:IAO_0000412 <http://purl.obolibrary.org/obo/uberon.owl> .

