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To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).

define using PATO mulit-potent or oligopotent?

Legacy definition: A cylindrical epithelial cell in the innermost layer of the enamel organ. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the dental enamel), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992).

legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin.

Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth.

non-encoded relationships from VSAO - capable_of_producing mineralized extracellular matrix. part_of osteoid

Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.

need to add non-terminally differentiated osteoblast to CL and use that for the develops from.

develops_from differs from CL as need to add the non-terminally differentiated odontoblast class to CL

CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def).

is hypertrophic pathological or normal? and can it be described using a pato term?

VSAO relationship simplified OBO_REL:integral_part_of cellular bone tissue

Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO.

NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. http://www.copewithcytokines.de/cope.cgi?key=scleroblasts

NOTE: TO DO, notochord development still needs work.

Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.

An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.

Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.

Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'.

Some intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.

Ligamentous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance.

Tendonous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance.

Cartilage is a type of dense connective tissue. It is composed of specialized cells called chondrocytes (CL:0000138) that produce a large amount of extracellular matrix composed of collagen fibers, abundant ground substance rich in proteoglycan, and elastin fibers

Term resides in TAO.

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Derived from cells surrounding the notochord (possibly the slerotome). Disparate from (not derived from) notochord.

Examples of appendicular ossicles include the patella and meniscus of the knee joint.

Ossicles are composed of a combination skeletal tissues, including bone, calcified cartilage, hyaline cartilage, etc, and exhibit variable development across species. Ossicles are not necessarily jointed, and examples include the menisci of synovial joints, "Panda's thumb" (radial sesamoid), cardiac skeletal elements, sclerotic bones, middle ear ossicles, and sesamoids.

Examples of axial ossicles include the ossified tendons adjacent to the neural spines of the vertebral column.

Sesamoids are often endochondral replacement elements and in addition to bone tissue, may also be composed of articular cartilage, fibrocartilage, hyaline cartilage, and calcified cartilage.

In sarcopterygians; analogous in position to postcleithrum in actinopterygians.

A scapular complex is described in placoderms (Goujet and Young, 1995).

Each pectoral lepidotrichium may be unsegmented (e.g., spine), segmented but unbranched (e.g., leading ray) or segmented and branched. Definition of lepidotrichium by Schultze and Arratia (1989: 217). For additional information about lepidotrichia see Arratia et al. 2001 and Arratia 2008.